                         SEQUENCE LISTING

<110>  ImmuneXpress Pty Ltd
 
<120>  TRIAGE BIOMARKERS AND USES THEREFOR

<130>  35258599/VPA

<140>  Unassigned
<141>  2016-12-20

<150>  2015905392
<151>  2015-12-24

<160>  358   

<170>  PatentIn version 3.5

<210>  1
<211>  2757
<212>  DNA
<213>  Homo sapiens

<400>  1
atgccagggg gcgcaggcgc cgcccggctc tgcttgctgg cgtttgccct gcagcccctc       60

cggccgcggg cggcgcggga gcctggatgg acaagaggaa gtgaggaagg cagccccaag      120

ctgcagcatg aacttatcat acctcagtgg aagacttcag aaagccccgt gagagaaaag      180

catccactca aagctgagct cagggtaatg gctgaggggc gagaactgat cctggacctg      240

gagaagaatg agcaactttt tgctccttcc tacacagaaa cccattatac ttcaagtggt      300

aaccctcaaa ccaccacacg gaaattggag gatcactgct tttaccacgg cacggtgagg      360

gagacagaac tgtccagcgt cacgctcagc acttgccgag gaattagagg actgattacg      420

gtgagcagca acctcagcta cgtcatcgag cccctccctg acagcaaggg ccaacacctt      480

atttacagat ctgaacatct caagccgccc ccgggaaact gtgggttcga gcactccaag      540

cccaccacca gggactgggc tcttcagttt acacaacaga ccaagaagcg acctcgcagg      600

atgaaaaggg aagatttaaa ctccatgaag tatgtggagc tttacctcgt ggctgattat      660

ttagagtttc agaagaatcg acgagaccag gacgccacca aacacaagct catagagatc      720

gccaactatg ttgataagtt ttaccgatcc ttgaacatcc ggattgctct cgtgggcttg      780

gaagtgtgga cccacgggaa catgtgtgaa gtttcagaga atccatattc taccctctgg      840

tcctttctca gttggaggcg caagctgctt gcccagaagt accatgacaa cgcccaatta      900

atcacgggca tgtccttcca cggcaccacc atcggcctgg cccccctcat ggccatgtgc      960

tctgtgtacc agtctggagg agtcaacatg gaccactccg agaatgccat tggcgtggct     1020

gccaccatgg cccacgagat gggccacaac tttggcatga cccatgattc tgcagattgc     1080

tgctcggcca gtgcggctga tggtgggtgc atcatggcag ctgccactgg gcaccccttt     1140

cccaaagtgt tcaatggatg caacaggagg gagctggaca ggtatctgca gtcaggtggt     1200

ggaatgtgtc tctccaacat gccagacacc aggatgttgt atggaggccg gaggtgtggg     1260

aacgggtatc tggaagatgg ggaagagtgt gactgtggag aagaagagga atgtaacaac     1320

ccctgctgca atgcctctaa ttgtaccctg aggccggggg cggagtgtgc tcacggctcc     1380

tgctgccacc agtgtaagct gttggctcct gggaccctgt gccgcgagca ggccaggcag     1440

tgtgacctcc cggagttctg tacgggcaag tctccccact gccctaccaa cttctaccag     1500

atggatggta ccccctgtga gggcggccag gcctactgct acaacggcat gtgcctcacc     1560

taccaggagc agtgccagca gctgtgggga cccggagccc gacctgcccc tgacctctgc     1620

ttcgagaagg tgaatgtggc aggagacacc tttggaaact gtggaaagga catgaatggt     1680

gaacacagga agtgcaacat gagagatgcg aagtgtggga agatccagtg tcagagctct     1740

gaggcccggc ccctggagtc caacgcggtg cccattgaca ccactatcat catgaatggg     1800

aggcagatcc agtgccgggg cacccacgtc taccgaggtc ctgaggagga gggtgacatg     1860

ctggacccag ggctggtgat gactggaacc aagtgtggct acaaccatat ttgctttgag     1920

gggcagtgca ggaacacctc cttctttgaa actgaaggct gtgggaagaa gtgcaatggc     1980

catggggtct gtaacaacaa ccagaactgc cactgcctgc cgggctgggc cccgcccttc     2040

tgcaacacac cgggccacgg gggcagtatc gacagtgggc ctatgccccc tgagagtgtg     2100

ggtcctgtgg tagctggagt gttggtggcc atcttggtgc tggcggtcct catgctgatg     2160

tactactgct gcagacagaa caacaaacta ggccaactca agccctcagc tctcccttcc     2220

aagctgaggc aacagttcag ttgtcccttc agggtttctc agaacagcgg gactggtcat     2280

gccaacccaa ctttcaagct gcagacgccc cagggcaagc gaaaggtgat caacactccg     2340

gaaatcctgc ggaagccctc ccagcctcct ccccggcccc ctccagatta tctgcgtggt     2400

gggtccccac ctgcaccact gccagctcac ctgagcaggg ctgctaggaa ctccccaggg     2460

cccgggtctc aaatagagag gacggagtcg tccaggaggc ctcctccaag ccggccaatt     2520

ccccccgcac caaattgcat cgtttcccag gacttctcca ggcctcggcc gccccagaag     2580

gcactcccgg caaacccagt gccaggccgc aggagcctcc ccaggccagg aggtgcatcc     2640

ccactgcggc cccctggtgc tggccctcag cagtcccggc ctctggcagc acttgcccca     2700

aagtttccag aatacagatc acagagggct ggagggatga ttagctcgaa aatctag        2757


<210>  2
<211>  2214
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaatggtg attctcgtgc tgcggtggtg acctcaccac ccccgaccac agcccctcac       60

aaggagaggt acttcgaccg agtagatgag aacaacccag agtacttgag ggagaggaac      120

atggcaccag accttcgcca ggacttcaac atgatggagc aaaagaagag ggtgtccatg      180

attctgcaaa gccctgcttt ctgtgaagaa ttggaatcaa tgatacagga gcaatttaag      240

aaggggaaga accccacagg cctattggca ttacagcaga ttgcagattt tatgaccacg      300

aatgtaccaa atgtctaccc agcagctccg caaggaggga tggctgcctt aaacatgagt      360

cttggtatgg tgactcctgt gaacgatctt agaggatctg attctattgc gtatgacaaa      420

ggagagaagt tattacggtg taaattggca gcgttttata gactagcaga tctctttggg      480

tggtctcagc ttatctacaa tcatatcaca accagagtga actccgagca ggaacacttc      540

ctcattgtcc cttttgggct tctttacagt gaagtgactg catccagttt ggttaagatc      600

aatctacaag gagatatagt agatcgtgga agcactaatc tgggagtgaa tcaggccggc      660

ttcaccttac actctgcaat ttatgctgca cgcccggacg tgaagtgcgt cgtgcacatt      720

cacaccccag caggggctgc ggtctctgca atgaaatgtg gcctcttgcc aatctccccg      780

gaggcgcttt cccttggaga agtggcttat catgactacc atggcattct ggttgatgaa      840

gaggaaaaag ttttgattca gaaaaatctg gggcctaaaa gcaaggttct tattctccgg      900

aaccatgggc tcgtgtcagt tggagagagc gttgaggagg ccttctatta catccataac      960

cttgtggttg cctgtgagat ccaggttcga actctggcca gtgcaggagg accagacaac     1020

ttagtcctgc tgaatcctga gaagtacaaa gccaagtccc gttccccagg gtctccggta     1080

ggggaaggca ctggatcgcc tcccaagtgg cagattggtg agcaggaatt tgaagccctc     1140

atgcggatgc tcgataatct gggctacaga actggctacc cttatcgata ccctgctctg     1200

agagagaagt ctaaaaaata cagcgatgtg gaggttcctg ctagtgtcac aggttactcc     1260

tttgctagtg acggtgattc gggcacttgc tccccactca gacacagttt tcagaagcag     1320

cagcgggaga agacaagatg gctgaactct ggccggggcg acgaagcttc cgaggaaggg     1380

cagaatggaa gcagtcccaa gtcgaagact aagtggacta aagaggatgg acatagaact     1440

tccacctctg ctgtccctaa cctgtttgtt ccattgaaca ctaacccaaa agaggtccag     1500

gagatgagga acaagatccg agagcagaat ttacaggaca ttaagacggc tggccctcag     1560

tcccaggttt tgtgtggtgt agtgatggac aggagcctcg tccagggaga gctggtgacg     1620

gcctccaagg ccatcattga aaaggagtac cagccccacg tcattgtgag caccacgggc     1680

cccaacccct tcaccacact cacagaccgt gagctggagg agtaccgcag ggaggtggag     1740

aggaagcaga agggctctga agagaatctg gacgaggcta gagaacagaa agaaaagagt     1800

cctccagacc agcctgcggt cccccacccg cctcccagca ctcccatcaa gctggaggaa     1860

gaccttgtgc cggagccgac tactggagat gacagtgatg ctgccacctt taagccaact     1920

ctccccgatc tgtcccctga tgaaccttca gaagcactcg gcttcccaat gttagagaag     1980

gaggaggaag cccatagacc cccaagcccc actgaggccc ctactgaggc cagccccgag     2040

ccagccccag acccagcccc ggtggctgaa gaggctgccc cctcagctgt cgaggagggg     2100

gccgccgcgg accctggcag cgatgggtct ccaggcaagt ccccgtccaa aaagaagaag     2160

aagttccgta ccccgtcctt tctgaagaag agcaagaaga agagtgactc ctga           2214


<210>  3
<211>  2661
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcgtggct tcaacctgct cctcttctgg ggatgttgtg ttatgcacag ctgggaaggg       60

cacataagac ccacacggaa accaaacaca aagggtaata actgtagaga cagtaccttg      120

tgcccagctt atgccacctg caccaataca gtggacagtt actattgcgc ttgcaaacaa      180

ggcttcctgt ccagcaatgg gcaaaatcac ttcaaggatc caggagtgcg atgcaaagat      240

attgatgaat gttctcaaag cccccagccc tgtggtccta actcatcctg caaaaacctg      300

tcagggaggt acaagtgcag ctgtttagat ggtttctctt ctcccactgg aaatgactgg      360

gtcccaggaa agccgggcaa tttctcctgt actgatatca atgagtgcct caccagcagc      420

gtctgccctg agcattctga ctgtgtcaac tccatgggaa gctacagttg cagctgtcaa      480

gttggattca tctctagaaa ctccacctgt gaagacgtgg atgaatgtgc agatccaaga      540

gcttgcccag agcatgcaac ttgtaataac actgttggaa actactcttg tttctgcaac      600

ccaggatttg aatccagcag tggccacttg agtttccagg gtctcaaagc atcgtgtgaa      660

gatattgatg aatgcactga aatgtgcccc atcaattcaa catgcaccaa cactcctggg      720

agctactttt gcacctgcca ccctggcttt gcaccaagca atggacagtt gaatttcaca      780

gaccaaggag tggaatgtag agatattgat gagtgccgcc aagatccatc aacctgtggt      840

cctaattcta tctgcaccaa tgccctgggc tcctacagct gtggctgcat tgcaggcttt      900

catcccaatc cagaaggctc ccagaaagat ggcaacttca gctgccaaag ggttctcttc      960

aaatgtaagg aagatgtgat acccgataat aagcagatcc agcaatgcca agagggaacc     1020

gcagtgaaac ctgcatatgt ctccttttgt gcacaaataa ataacatctt cagcgttctg     1080

gacaaagtgt gtgaaaataa aacgaccgta gtttctctga agaatacaac tgagagcttt     1140

gtccctgtgc ttaaacaaat atccacgtgg actaaattca ccaaggaaga gacgtcctcc     1200

ctggccacag tcttcctgga gagtgtggaa agcatgacac tggcatcttt ttggaaaccc     1260

tcagcaaata tcactccggc tgttcggacg gaatacttag acattgagag caaagttatc     1320

aacaaagaat gcagtgaaga gaatgtgacg ttggacttgg tagccaaggg ggataagatg     1380

aagatcgggt gttccacaat tgaggaatct gaatccacag agaccactgg tgtggctttt     1440

gtctcctttg tgggcatgga atcggtttta aatgagcgct tcttcaaaga ccaccaggct     1500

cccttgacca cctctgagat caagctgaag atgaattctc gagtcgttgg gggcataatg     1560

actggagaga agaaagacgg cttctcagat ccaatcatct acactctgga gaacattcag     1620

ccaaagcaga agtttgagag gcccatctgt gtttcctgga gcactgatgt gaagggtgga     1680

agatggacat cctttggctg tgtgatcctg gaagcttctg agacatatac catctgcagc     1740

tgtaatcaga tggcaaatct tgccgttatc atggcgtctg gggagctcac gatggacttt     1800

tccttgtaca tcattagcca tgtaggcatt atcatctcct tggtgtgcct cgtcttggcc     1860

atcgccacct ttctgctgtg tcgctccatc cgaaatcaca acacctacct ccacctgcac     1920

ctctgcgtgt gtctcctctt ggcgaagact ctcttcctcg ccggtataca caagactgac     1980

aacaagatgg gctgcgccat catcgcgggc ttcctgcact accttttcct tgcctgcttc     2040

ttctggatgc tggtggaggc tgtgatactg ttcttgatgg tcagaaacct gaaggtggtg     2100

aattacttca gctctcgcaa catcaagatg ctgcacatct gtgcctttgg ttatgggctg     2160

ccgatgctgg tggtggtgat ctctgccagt gtgcagccac agggctatgg aatgcataat     2220

cgctgctggc tgaatacaga gacagggttc atctggagtt tcttggggcc agtttgcaca     2280

gttatagtga tcaactccct tctcctgacc tggaccttgt ggatcctgag gcagaggctt     2340

tccagtgtta atgccgaagt ctcaacgcta aaagacacca ggttactgac cttcaaggcc     2400

tttgcccagc tcttcatcct gggctgctcc tgggtgctgg gcatttttca gattggacct     2460

gtggcaggtg tcatggctta cctgttcacc atcatcaaca gcctgcaggg ggccttcatc     2520

ttcctcatcc actgtctgct caacggccag gtacgagaag aatacaagag gtggatcact     2580

gggaagacga agcccagctc ccagtcccag acctcaagga tcttgctgtc ctccatgcca     2640

tccgcttcca agacgggtta a                                               2661


<210>  4
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  4
atgagccaaa ccagggattt acagggagga aaagctttcg gactgctgaa ggcccagcag       60

gaagagaggc tggatgagat caacaagcaa ttcctagacg atcccaaata tagcagtgat      120

gaggatctgc cctccaaact ggaaggcttc aaagagaaat acatggagtt tgaccttaat      180

ggaaatggcg atattgatat catgtccctg aaacgaatgc tggagaaact tggagtcccc      240

aagactcacc tagagctaaa gaaattaatt ggagaggtgt ccagtggctc cggggagacg      300

ttcagctacc ctgactttct caggatgatg ctgggcaaga gatctgccat cctaaaaatg      360

atcctgatgt atgaggaaaa agcgagagaa aaggaaaagc caacaggccc cccagccaag      420

aaagctatct ctgagttgcc ctga                                             444


<210>  5
<211>  246
<212>  DNA
<213>  Homo sapiens

<400>  5
atgggccagc tttgctgctt tcctttctca agagatgaag gaaaaatcag tgaaaagaac       60

ggaggggagc ccgatgacgc tgaactagta aggctcagta agaggctggt ggagaacgcg      120

gtgctcaagg ctgtccagca gtatctggag gaaacacaga ataaaaacaa gccgggggag      180

gggagctctg tgaaaaccga agcagctgat cagaatggca atgacaatga gaacaacagg      240

aaatga                                                                 246


<210>  6
<211>  1443
<212>  DNA
<213>  Homo sapiens

<400>  6
atgagcgacg tggctattgt gaaggagggt tggctgcaca aacgagggga gtacatcaag       60

acctggcggc cacgctactt cctcctcaag aatgatggca ccttcattgg ctacaaggag      120

cggccgcagg atgtggacca acgtgaggct cccctcaaca acttctctgt ggcgcagtgc      180

cagctgatga agacggagcg gccccggccc aacaccttca tcatccgctg cctgcagtgg      240

accactgtca tcgaacgcac cttccatgtg gagactcctg aggagcggga ggagtggaca      300

accgccatcc agactgtggc tgacggcctc aagaagcagg aggaggagga gatggacttc      360

cggtcgggct cacccagtga caactcaggg gctgaagaga tggaggtgtc cctggccaag      420

cccaagcacc gcgtgaccat gaacgagttt gagtacctga agctgctggg caagggcact      480

ttcggcaagg tgatcctggt gaaggagaag gccacaggcc gctactacgc catgaagatc      540

ctcaagaagg aagtcatcgt ggccaaggac gaggtggccc acacactcac cgagaaccgc      600

gtcctgcaga actccaggca ccccttcctc acagccctga agtactcttt ccagacccac      660

gaccgcctct gctttgtcat ggagtacgcc aacgggggcg agctgttctt ccacctgtcc      720

cgggagcgtg tgttctccga ggaccgggcc cgcttctatg gcgctgagat tgtgtcagcc      780

ctggactacc tgcactcgga gaagaacgtg gtgtaccggg acctcaagct ggagaacctc      840

atgctggaca aggacgggca cattaagatc acagacttcg ggctgtgcaa ggaggggatc      900

aaggacggtg ccaccatgaa gaccttttgc ggcacacctg agtacctggc ccccgaggtg      960

ctggaggaca atgactacgg ccgtgcagtg gactggtggg ggctgggcgt ggtcatgtac     1020

gagatgatgt gcggtcgcct gcccttctac aaccaggacc atgagaagct ttttgagctc     1080

atcctcatgg aggagatccg cttcccgcgc acgcttggtc ccgaggccaa gtccttgctt     1140

tcagggctgc tcaagaagga ccccaagcag aggcttggcg ggggctccga ggacgccaag     1200

gagatcatgc agcatcgctt ctttgccggt atcgtgtggc agcacgtgta cgagaagaag     1260

ctcagcccac ccttcaagcc ccaggtcacg tcggagactg acaccaggta ttttgatgag     1320

gagttcacgg cccagatgat caccatcaca ccacctgacc aagatgacag catggagtgt     1380

gtggacagcg agcgcaggcc ccacttcccc cagttctcct actcggccag cggcacggcc     1440

tga                                                                   1443


<210>  7
<211>  879
<212>  DNA
<213>  Homo sapiens

<400>  7
atgaaccctt tctggagcat gtctacaagc tctgtacgca aacgatctga aggtgaagag       60

aagacattaa caggggacgt gaaaaccagt cctccacgaa ctgcaccaaa gaaacagctg      120

ccttctattc ccaaaaatgc tttgcccata actaagccta catctcctgc cccagcagca      180

cagtcaacaa atggcacgca tgcgtcctat ggacccttct acctggaata ctctcttctt      240

gcagaattta ccttggttgt gaagcagaag ctaccaggcg tctatgtgca gccatcttat      300

cgctctgcat taatgtggtt tggagtaata ttcatacggc atggacttta ccaagatggc      360

gtatttaagt ttacagttta catccctgat aactatccag atggtgactg tccacgcttg      420

gtgttcgata ttcctgtctt tcacccgcta gttgatccca cctcaggtga gctggatgtg      480

aagagagcat ttgcaaaatg gaggcggaac cataatcata tttggcaggt attaatgtat      540

gcaaggagag ttttctacaa gattgataca gcaagccccc tgaacccaga ggctgcagta      600

ctgtatgaaa aagatattca gctttttaaa agtaaagttg ttgacagtgt taaggtgtgc      660

actgctcgtt tgtttgacca acctaaaata gaagacccct atgcaattag cttttctcca      720

tggaatcctt ctgtacatga tgaagccaga gaaaagatgc tgactcagaa aaagcctgaa      780

gaacagcaca ataaaagtgt tcatgttgct ggcctgtcat gggtaaagcc tggctcagta      840

cagcctttca gtaaagaaga gaaaacagtg gcgacttaa                             879


<210>  8
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  8
atgccctacc aatatccagc actgaccccg gagcagaaga aggagctgtc tgacatcgct       60

caccgcatcg tggcacctgg caagggcatc ctggctgcag atgagtccac tgggagcatt      120

gccaagcggc tgcagtccat tggcaccgag aacaccgagg agaaccggcg cttctaccgc      180

cagctgctgc tgacagctga cgaccgcgtg aacccctgca ttgggggtgt catcctcttc      240

catgagacac tctaccagaa ggcggatgat gggcgtccct tcccccaagt tatcaaatcc      300

aagggcggtg ttgtgggcat caaggtagac aagggcgtgg tccccctggc agggacaaat      360

ggcgagacta ccacccaagg gttggatggg ctgtctgagc gctgtgccca gtacaagaag      420

gacggagctg acttcgccaa gtggcgttgt gtgctgaaga ttggggaaca caccccctca      480

gccctcgcca tcatggaaaa tgccaatgtt ctggcccgtt atgccagtat ctgccagcag      540

aatggcattg tgcccatcgt ggagcctgag atcctccctg atggggacca tgacttgaag      600

cgctgccagt atgtgaccga gaaggtgctg gctgctgtct acaaggctct gagtgaccac      660

cacatctacc tggaaggcac cttgctgaag cccaacatgg tcaccccagg ccatgcttgc      720

actcagaagt tttctcatga ggagattgcc atggcgaccg tcacagcgct gcgccgcaca      780

gtgccccccg ctgtcactgg gatcaccttc ctgtctggag gccagagtga ggaggaggcg      840

tccatcaacc tcaatgccat taacaagtgc cccctgctga agccctgggc cctgaccttc      900

tcctacggcc gagccctgca ggcctctgcc ctgaaggcct ggggcgggaa gaaggagaac      960

ctgaaggctg cgcaggagga gtatgtcaag cgagccctgg ccaacagcct tgcctgtcaa     1020

ggaaagtaca ctccgagcgg tcaggctggg gctgctgcca gcgagtccct cttcgtctct     1080

aaccacgcct attaa                                                      1095


<210>  9
<211>  1005
<212>  DNA
<213>  Homo sapiens

<400>  9
atggaagctg cacatttttt cgaagggacc gagaagctgc tggaggtttg gttctcccgg       60

cagcagcccg acgcaaacca aggatctggg gatcttcgca ctatcccaag atctgagtgg      120

gacatacttt tgaaggatgt gcaatgttca atcataagtg tgacaaaaac tgacaagcag      180

gaagcttatg tactcagtga gagtagcatg tttgtctcca agagacgttt cattttgaag      240

acatgtggta ccaccctctt gctgaaagca ctggttcccc tgttgaagct tgctagggat      300

tacagtgggt ttgactcaat tcaaagcttc ttttattctc gtaagaattt catgaagcct      360

tctcaccaag ggtacccaca ccggaatttc caggaagaaa tagagtttct taatgcaatt      420

ttcccaaatg gagcagcata ttgtatggga cgtatgaatt ctgactgttg gtacttatat      480

actctggatt tcccagagag tcgggtaatc agtcagccag atcaaacctt ggaaattctg      540

atgagtgagc ttgacccagc agttatggac cagttctaca tgaaagatgg tgttactgca      600

aaggatgtca ctcgtgagag tggaattcgt gacctgatac caggttctgt cattgatgcc      660

acaatgttca atccttgtgg gtattcgatg aatggaatga aatcggatgg aacttattgg      720

actattcaca tcactccaga accagaattt tcttatgtta gctttgaaac aaacttaagt      780

cagacctcct atgatgacct gatcaggaaa gttgtagaag tcttcaagcc aggaaaattt      840

gtgaccacct tgtttgttaa tcagagttct aaatgtcgca cagtgcttgc ttcgccccag      900

aagattgaag gttttaagcg tcttgattgc cagagtgcta tgttcaatga ttacaatttt      960

gtttttacca gttttgctaa gaagcagcaa caacagcaga gttga                     1005


<210>  10
<211>  492
<212>  DNA
<213>  Homo sapiens

<400>  10
atggacgcct tagaaggaga gagctttgcg ctgtctttct cctccgcctc tgatgcagaa       60

tttgatgctg tggttggata tttagaggac attatcatgg atgacgagtt ccagttatta      120

cagagaaatt tcatggacaa gtactacctg gagtttgaag acacagaaga gaataaactc      180

atctacacac ctatttttaa tgaatacatt tctttggtag aaaaatacat tgaagaacag      240

ctgctgcagc ggattcctga gttcaacatg gcagccttca ccacaacatt acagcaccat      300

aaggatgaag tggctggtga catattcgac atgctgctca ccttcacaga ttttctggct      360

tttaaagaaa tgtttttgga ctacagagca gaaaaagaag gccgaggact ggacttaagc      420

agtggcttag tggtgacttc attgtgcaaa tcatcttctc tgccagcttc ccagaacaat      480

ctgcggcact ag                                                          492


<210>  11
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcgcagt ttgacactga ataccagcgc ctagaggcct cctatagtga ttcaccccca       60

ggggaggagg acctgttggt gcacgtcgcc gaggggagca agtcaccttg gcaccatatt      120

gaaaaccttg acctcttctt ctctcgagtt tataatctgc accagaagaa tggcttcaca      180

tgtatgctca tcggggagat ctttgagctc atgcagttcc tctttgtggt tgccttcact      240

accttcctgg tcagctgcgt ggactatgac atcctatttg ccaacaagat ggtgaaccac      300

agtcttcacc ctactgaacc cgtcaaggtc actctgccag acgccttttt gcctgctcaa      360

gtctgtagtg ccaggattca ggaaaatggc tcccttatca ccatcctggt cattgctggt      420

gtcttctgga tccaccggct tatcaagttc atctataaca tttgctgcta ctgggagatc      480

cactccttct acctgcacgc tctgcgcatc cctatgtctg cccttccgta ttgcacgtgg      540

caagaagtgc aggcccggat cgtgcagacg cagaaggagc accagatctg catccacaaa      600

cgtgagctga cagaactgga catctaccac cgcatcctcc gtttccagaa ctacatggtg      660

gcactggtta acaaatccct cctgcctctg cgcttccgcc tgcctggcct cggggaagct      720

gtcttcttca cccgtggtct caagtacaac tttgagctga tcctcttctg gggacctggc      780

tctctgtttc tcaatgaatg gagcctcaag gccgagtaca aacgtggggg gcaacggcta      840

gagctggccc agcgcctcag caaccgcatc ctgtggattg gcatcgctaa cttcctgctg      900

tgccccctca tcctcatatg gcaaatcctc tatgccttct tcagctatgc tgaggtgctg      960

aagcgggagc cgggggccct gggagcacgc tgctggtcac tctatggccg ctgctacctc     1020

cgccacttca acgagctgga gcacgagctg cagtcccgcc tcaaccgtgg ctacaagccc     1080

gcctccaagt acatgaattg cttcttgtca cctcttttga cactgctggc caagaatgga     1140

gccttcttcg ctggctccat cctggctgtg cttattgccc tcaccattta tgacgaagat     1200

gtgttggctg tggaacatgt gctgaccacc gtcacactcc tgggggtcac cgtgaccgtg     1260

tgcaggtcct ttatcccgga ccagcacatg gtgttctgcc ctgagcagct gctccgcgtg     1320

atcctcgctc acatccacta catgcctgac cactggcagg gtaatgccca ccgctcgcag     1380

acccgggacg agtttgccca gctcttccag tacaaggcag tgttcatttt ggaagagttg     1440

ctgagcccca ttgtcacacc cctcatcctc atcttctgcc tgcgcccacg ggccctggag     1500

attatagact tcttccgaaa cttcaccgtg gaggtcgttg gtgtgggaga tacctgctcc     1560

tttgctcaga tggatgttcg ccagcatggt catccccagt ggctatctgc tgggcagaca     1620

gaggcctcag tgtaccagca agctgaggat ggaaagacag agttgtcact catgcacttt     1680

gccatcacca accctggctg gcagccacca cgtgagagca cagccttcct aggcttcctc     1740

aaggagcagg ttcagcggga tggagcagct gctagcctcg cccaaggggg tctgctccct     1800

gaaaatgccc tctttacgtc tatccagtcc ttacaatctg agtctgagcc cctgagcctt     1860

atcgcaaatg tggtagctgg ctcatcctgc cggggccctc cactgcccag agacctgcag     1920

ggctccaggc acagggctga agtcgcctct gccctgcgct ccttctcccc gctgcaaccc     1980

gggcaggcgc ccacaggccg ggctcacagc accatgacag gctctggggt ggatgccagg     2040

acagccagct ccgggagcag cgtgtgggaa ggacagctgc agagcctggt gctgtcagaa     2100

tatgcatcca cagagatgag cctgcatgcc ctctatatgc accagctcca caagcagcag     2160

gcccaggctg aacctgagcg gcatgtatgg caccgccggg agagtgatga gagtggagaa     2220

agcgcccctg atgaaggggg agagggcgcc cgggcccccc agtctatccc tcgctctgct     2280

agctatccct gtgcagcacc ccggcctgga gctcctgaga ccactgccct gcatgggggc     2340

ttccagaggc gctacggtgg catcacagat cctggcacag tgcccagggt tccctctcat     2400

ttctctcggc tgcctcttgg agggtgggca gaagatgggc agtcggcatc aaggcaccct     2460

gagcccgtgc ccgaagaggg ctcggaggat gagctacccc ctcaggtgca caaggtatag     2520


<210>  12
<211>  3681
<212>  DNA
<213>  Homo sapiens

<400>  12
atggacaggg aagaaaggaa gaccatcaat cagggtcaag aagatgaaat ggagatttat       60

ggttacaatt tgagtcgctg gaagcttgcc atagtttctt taggagtgat ttgctctggt      120

gggtttctcc tcctcctcct ctattggatg cctgagtggc gggtgaaagc gacctgtgtc      180

agagctgcaa ttaaagactg tgaagtagtg ctgctgagga ctactgatga attcaaaatg      240

tggttttgtg caaaaattcg cgttctttct ttggaaactt acccagtttc aagtccaaaa      300

tctatgtcta ataagctttc aaatggccat gcagtttgtt taattgagaa tcccactgaa      360

gaaaataggc acaggatcag taaatattca cagactgaat cacaacagat tcgttatttc      420

acccaccata gtgtaaaata tttctggaat gataccattc acaattttga tttcttaaag      480

ggactggatg aaggtgtttc ttgtacgtca atttatgaaa agcatagtgc aggactgaca      540

aaggggatgc atgcctacag aaaactgctt tatggagtaa atgaaattgc tgtaaaagtg      600

ccttctgttt ttaagcttct aattaaagag gttctcaacc cattttacat tttccagctg      660

ttcagtgtta tactgtggag cactgatgaa tactattact atgctctagc tattgtggtt      720

atgtccatag tatcaatcgt aagctcacta tattccatta gaaagcaata tgttatgttg      780

catgacatgg tggcaactca tagtaccgta agagtttcag tttgtagagt aaatgaagaa      840

atagaagaaa tcttttctac cgaccttgtg ccaggagatg tcatggtcat tccattaaat      900

gggacaataa tgccttgtga tgctgtgctt attaatggta cctgcattgt aaacgaaagc      960

atgttaacag gagaaagtgt tccagtgaca aagactaatt tgccaaatcc ttcagtggat     1020

gtgaaaggaa taggagatga attatataat ccagaaacac ataaacgaca tactttgttt     1080

tgtgggacaa ctgttattca gactcgtttc tacactggag aactcgtcaa agccatagtt     1140

gttagaacag gatttagtac ttccaaagga cagcttgttc gttccatatt gtatcccaaa     1200

ccaactgatt ttaaactcta cagagatgcc tacttgtttc tactatgtct tgtggcagtt     1260

gctggcattg ggtttatcta cactattatt aatagcattt taaatgaggt acaagttggg     1320

gtcataatta tcgagtctct tgatattatc acaattactg tgccccctgc acttcctgct     1380

gcaatgactg ctggtattgt gtatgctcag agaagactga aaaaaatcgg tattttctgt     1440

atcagtcctc aaagaataaa tatttgtgga cagctcaatc ttgtttgctt tgacaagact     1500

ggaactctaa ctgaagatgg tttagatctt tgggggattc aacgagtgga aaatgcacga     1560

tttctttcac cagaagaaaa tgtgtgcaat gagatgttgg taaaatccca gtttgttgct     1620

tgtatggcta cttgtcattc acttacaaaa attgaaggag tgctctctgg tgatccactt     1680

gatctgaaaa tgtttgaggc tattggatgg attctggaag aagcaactga agaagaaaca     1740

gcacttcata atcgaattat gcccacagtg gttcgtcctc ccaaacaact gcttcctgaa     1800

tctacccctg caggaaacca agaaatggag ctgtttgaac ttccagctac ttatgagata     1860

ggaattgttc gccagttccc attttcttct gctttgcaac gtatgagtgt ggttgccagg     1920

gtgctggggg ataggaaaat ggacgcctac atgaaaggag cgcccgaggc cattgccggt     1980

ctctgtaaac ctgaaacagt tcctgtcgat tttcaaaacg ttttggaaga cttcactaaa     2040

cagggcttcc gtgtgattgc tcttgcacac agaaaattgg agtcaaaact gacatggcat     2100

aaagtacaga atattagcag agatgcaatt gagaacaaca tggattttat gggattaatt     2160

ataatgcaga acaaattaaa gcaagaaacc cctgcagtac ttgaagattt gcataaagcc     2220

aacattcgca ccgtcatggt cacaggtgac agtatgttga ctgctgtctc tgtggccaga     2280

gattgtggaa tgattctacc tcaggataaa gtgattattg ctgaagcatt acctccaaag     2340

gatgggaaag ttgccaaaat aaattggcat tatgcagact ccctcacgca gtgcagtcat     2400

ccatcagcaa ttgacccaga ggctattccg gttaaattgg tccatgatag cttagaggat     2460

cttcaaatga ctcgttatca ttttgcaatg aatggaaaat cattctcagt gatactggag     2520

cattttcaag accttgttcc taagttgatg ttgcatggca ccgtgtttgc ccgtatggca     2580

cctgatcaga agacacagtt gatagaagca ttgcaaaatg ttgattattt tgttgggatg     2640

tgtggtgatg gcgcaaatga ttgtggtgct ttgaagaggg cacacggagg catttcctta     2700

tcggagctcg aagcttcagt ggcatctccc tttacctcta agactcctag tatttcctgt     2760

gtgccaaacc ttatcaggga aggccgtgct gctttaataa cttccttctg tgtgtttaaa     2820

ttcatggcat tgtacagcat tatccagtac ttcagtgtta ctctgctgta ttctatctta     2880

agtaacctag gagacttcca gtttctcttc attgatctgg caatcatttt ggtagtggta     2940

tttacaatga gtttaaatcc tgcctggaaa gaacttgtgg cacaaagacc accttcgggt     3000

cttatatctg gggcccttct cttctccgtt ttgtctcaga ttatcatctg cattggattt     3060

caatctttgg gttttttttg ggtcaaacag caaccttggt atgaagtgtg gcatccaaaa     3120

tcagatgctt gtaatacaac aggaagcggg ttttggaatt cttcacacgt agacaatgaa     3180

accgaacttg atgaacataa tatacaaaat tatgaaaata ccacagtgtt ttttatttcc     3240

agttttcagt acctcatagt ggcaattgcc ttttcaaaag gaaaaccctt caggcaacct     3300

tgctacaaaa attatttttt tgttttttct gtgatttttt tatatatttt tatattattc     3360

atcatgttgt atccagttgc ctctgttgac caggttcttc agatagtgtg tgtaccatat     3420

cagtggcgtg taactatgct catcattgtt cttgtcaatg cctttgtgtc tatcacagtg     3480

gaggagtcag tggatcggtg gggaaaatgc tgcttaccct gggccctggg ctgtagaaag     3540

aagacaccaa aggcaaagta catgtatctg gcgcaggagc tcttggttga tccagaatgg     3600

ccaccaaaac ctcagacaac cacagaagct aaagctttag ttaaggagaa tggatcatgt     3660

caaatcatca ccataacata g                                               3681


<210>  13
<211>  2496
<212>  DNA
<213>  Homo sapiens

<400>  13
atgggggagc ttttccggag tgaagaaatg acactggccc agctttttct acagtcagag       60

gctgcttatt gttgtgtcag tgaattagga gaacttggaa aggttcagtt tcgtgactta      120

aatccagatg tgaatgtttt ccaacggaaa tttgtgaatg aagttagaag atgtgaagaa      180

atggatcgaa agcttcgatt tgttgagaaa gagataagaa aagctaacat tccgattatg      240

gacaccggtg aaaacccaga ggttcccttc ccccgggaca tgattgactt agaggccaat      300

tttgagaaga ttgaaaatga actgaaggaa atcaacacaa accaggaagc tctgaagaga      360

aacttcctgg aactgaccga attaaaattt atacttcgca aaactcagca attttttgat      420

gagatggcgg atccagactt gttggaagag tcctcatccc tcttggagcc aagtgagatg      480

ggaagaggca ctcctttaag acttggcttc gtggctggtg tcattaaccg ggagcgcatc      540

cctacttttg agcgcatgct ttggcgggta tgccggggaa atgtgttcct gcgacaggct      600

gaaatcgaga accccctgga ggatcctgtg actggcgact acgtgcacaa gtctgtgttt      660

atcattttct tccaaggcga tcagctgaaa aacagagtca agaaaatctg tgaagggttc      720

cgagcctcac tctatccctg tcctgagaca ccacaggaga ggaaggaaat ggcttctgga      780

gtgaatacca ggattgatga tctccaaatg gttctgaatc aaacggagga tcaccgccag      840

agggttctgc aggcagctgc taagaacatc cgtgtctggt tcatcaaagt gcggaagatg      900

aaggccatct atcacaccct gaacctgtgc aacatagatg tgactcagaa atgcttgatt      960

gcagaggtct ggtgccctgt caccgacctt gactccatcc agtttgcact cagaaggggc     1020

acggaacaca gtggttccac tgtaccttcc attttgaaca ggatgcagac aaaccagact     1080

cccccaacct ataacaaaac caacaagttt acctatggct ttcagaacat agtagatgct     1140

tatggaattg gaacttaccg agagataaat ccagctccgt atactattat cacgttccct     1200

tttctatttg ctgtgatgtt tggagacttc ggtcatggca ttttaatgac cctttttgct     1260

gtgtggatgg tactgaggga gagccggatc ctttcccaga agaatgagaa tgagatgttt     1320

agcactgtgt tcagtggtcg atacattatt ttattgatgg gtgtgttctc catgtacact     1380

ggcctcatct acaatgattg cttttccaag tctcttaata tctttgggtc atcctggagt     1440

gtacggccga tgtttactta taattggact gaagagacgc ttcgggggaa ccctgttcta     1500

cagctgaacc cagccctccc tggagtgttt ggtggaccat acccttttgg cattgatcca     1560

atttggaaca ttgctaccaa taaactgacg ttcttgaact cctttaagat gaagatgtct     1620

gttatccttg gtatcatcca tatgctgttt ggagtcagcc tgagtctgtt caaccatatc     1680

tatttcaaga agcccctgaa tatctacttt ggatttattc ctgaaataat cttcatgacc     1740

tctttgtttg gctatttggt tatccttatt ttttacaagt ggacggccta tgatgctcat     1800

acctctgaga atgcaccaag ccttctgatc catttcataa acatgttcct cttttcctac     1860

ccagagtctg gttattcaat gttgtattct ggacagaaag gaattcagtg tttcctggta     1920

gtggttgcac tactgtgtgt accttggatg ctgctgttta aaccattggt ccttcgccgt     1980

cagtatttga ggagaaagca tttgggaact ctcaactttg gtgggatcag ggtgggcaac     2040

ggaccgacag aggaggatgc tgagattatt cagcatgacc agctctccac ccactcagag     2100

gacgcagacg agtttgactt tggggacacc atggtccacc aggccatcca caccatcgag     2160

tactgcctgg gctgcatctc caacactgcc tcctacttgc ggctctgggc cctcagcctc     2220

gctcatgcgc agctgtctga ggtgctttgg accatggtga tccacatcgg cctgagcgtg     2280

aagagcttgg cgggaggttt ggtgctgttc ttcttcttca ctgcctttgc caccctgacc     2340

gtggccatcc tcctgatcat ggagggcctc tcggcctttc tccacgcact gcgcttacac     2400

tgggttgagt tccagaataa attctacagc gggaccggtt tcaagttctt acccttctcc     2460

ttcgagcata ttcgggaagg gaagtttgaa gagtga                               2496


<210>  14
<211>  3579
<212>  DNA
<213>  Homo sapiens

<400>  14
atgttctgca gtgaaaagaa attgcgtgaa gtggaacgga tagtgaaagc caatgaccgt       60

gaatataatg aaaagttcca gtatgcggat aatcgtatcc acacatcgaa atataatatt      120

ctcaccttct tgccaattaa tttatttgaa cagttccaaa gagtggcaaa tgcctatttt      180

ctttgccttc tgattttaca gctaattcca gaaatttcct ccttgacctg gtttaccacc      240

attgtgcctt tggtcctggt gataactatg acagctgtca aagatgccac agatgactat      300

tttcgccaca agagtgataa tcaagtgaat aatcggcagt ctgaagtgct catcaacagc      360

aaactgcaga atgaaaaatg gatgaatgtc aaagtgggag acatcattaa attagaaaat      420

aaccaatttg ttgctgctga tttacttctc ctatcaagta gtgagccaca tggtctctgt      480

tatgttgaaa ctgctgagct tgatggggaa acgaacctaa aagtccgcca tgcactatca      540

gttacttcag aacttggagc agatatcagc agacttgcag ggtttgatgg gattgttgtc      600

tgtgaggtgc ctaacaacaa gttagataaa ttcatgggaa tcctttcttg gaaagacagc      660

aagcattccc tcaacaatga gaagataatc ctgagaggct gcatcctgag aaataccagc      720

tggtgttttg gaatggttat ttttgcaggt cctgacacta aactaatgca gaatagtggt      780

aagacaaagt ttaaaaggac aagcattgat agattgatga atactctagt actatggatt      840

tttgggtttc tgatatgctt gggaattatt cttgcaatag gaaattcaat ctgggagagt      900

caaactgggg accaattcag aactttcctc ttttggaatg aaggagagaa gagctctgtg      960

ttctccggat tcttaacatt ctggtcatat attattattc tcaatacagt tgtacccatt     1020

tccttatatg tgagtgtgga agtaattcgt ctaggacaca gttattttat aaactgggac     1080

cggaagatgt attattctcg aaaagcaata cctgcagtgg ctcgaacgac cacgctcaat     1140

gaggaactgg ggcagattga gtacattttc tccgacaaaa cgggtaccct cactcaaaac     1200

atcatgacct ttaaaagatg ttccattaat gggagaatct atggtgaagt acatgatgac     1260

ctggatcaga agacagaaat aactcaggaa aaagagcctg tggatttctc agtcaaatct     1320

caagcggata gagaatttca gttctttgac caccatctga tggaatccat taaaatgggt     1380

gatcccaaag ttcatgaatt ccttaggtta cttgctctct gccacactgt aatgtcagaa     1440

gagaatagcg caggagagct gatttaccaa gttcagtcac ctgatgaagg ggctctagtg     1500

actgccgcta gaaattttgg gttcattttt aaatcccgga ccccagagac cataacaata     1560

gaagaattgg gaacactagt tacttatcaa ttacttgcct ttttggattt caacaacacc     1620

agaaaaagga tgtctgtcat agttcgaaac ccagaaggac agataaagct ttattccaaa     1680

ggagcagata ctattctgtt tgaaaaactt catccttcca atgaagtcct tttgtctttg     1740

acgtcagacc acctcagtga atttgcaggg gaaggccttc ggaccttggc catcgcatac     1800

agagacctgg atgacaagta ctttaaagag tggcataaga tgcttgaaga tgcgaatgct     1860

gccacagaag agagggatga acgaatagct gggctatatg aagaaattga aagagatttg     1920

atgctactag gtgccactgc tgtagaagat aagttacagg agggtgttat tgaaacagtt     1980

acaagtttat cactagccaa tattaagatc tgggtcctaa caggagacaa acaagaaact     2040

gccatcaaca tcggttatgc ctgcaacatg ctgactgacg acatgaatga tgtgtttgtg     2100

atagcaggga ataatgctgt ggaagtgaga gaagaactca ggaaagcaaa acaaaatttg     2160

tttggacaaa acagaaattt ttccaatggc catgtagttt gtgaaaaaaa gcagcagctg     2220

gagttggatt ctattgtaga agaaaccata acaggagatt atgccttaat cataaatggc     2280

cacagtttgg ctcatgccct agaaagtgat gtcaagaatg atctcctaga acttgcttgc     2340

atgtgtaaga ctgtaatttg ctgcagggtc actccactcc agaaagccca agtggtagag     2400

ctggtgaaga agtacagaaa tgctgttact ttggccattg gtgatggagc caatgatgtc     2460

agcatgatta aaagtgctca cattggtgtt ggcatcagcg gccaggaagg attgcaagca     2520

gtcttagcca gcgactattc atttgcacag tttagatatc tccaaaggct tctccttgtt     2580

catggaaggt ggtcttattt ccgaatgtgc aaattcttat gctatttctt ctataagaat     2640

tttgcattta cacttgtgca tttctggttt ggtttcttct gtggtttctc agcccagact     2700

gtttatgacc agtggttcat cacccttttt aacattgttt acacatcact gcctgtttta     2760

gccatgggga tttttgacca ggatgtgagt gaccagaaca gcgtggactg tccccagctc     2820

tacaaaccag gacagctgaa tctgcttttt aacaagcgta aatttttcat ttgcgtgttg     2880

catggaatct acacctcatt agtccttttc ttcatcccct atggggcctt ttacaacgtg     2940

gctggagaag atgggcaaca tattgctgac taccagtcct ttgcagttac catggccaca     3000

tctttggtca ttgtggtcag tgtgcagata gccttggata ccagttactg gactttcatt     3060

aatcacgtct tcatctgggg gagcattgcc atttatttct ccattttatt tacaatgcac     3120

agtaatggca tctttggcat cttcccaaac cagtttccat ttgttggtaa tgcacgacat     3180

tccctgaccc agaagtgcat ctggcttgta attctcttaa caacagtggc ttcagttatg     3240

ccagtggtgg cattcagatt tttgaaggtg gatttatacc caaccctgag tgatcagatc     3300

cgccggtggc agaaggctca aaagaaggca aggcctccaa gtagccgaag gcctcggacc     3360

cgcaggtcaa gctcaagaag gtctggatat gcttttgctc accaagaagg ctatggagag     3420

cttatcacat ctggaaaaaa tatgcgagct aaaaatccac ccccaacatc agggctggaa     3480

aagacacatt ataatagcac tagctggatt gaaaatttat gtaagaaaac cacagacacc     3540

gtgagcagct ttagccagga taaaacagtg aaactgtga                            3579


<210>  15
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  15
atgggcaaga agcacaagaa gcacaagtcg gacaaacacc tctacgagga gtatgtagag       60

aagcccttga agctggtcct caaagtagga gggaacgaag tcaccgaact ctccacgggc      120

agctcggggc acgactccag cctcttcgaa gacaaaaacg atcatgacaa acacaaggac      180

agaaagcgga aaaagagaaa gaaaggagag aagcagattc caggggaaga aaaggggaga      240

aaacggagaa gagttaagga ggataaaaag aagcgagatc gagaccgggt ggagaatgag      300

gcagaaaaag atctccagtg tcacgcccct gtgagattag acttgcctcc tgagaagcct      360

ctcacaagct ctttagccaa acaagaagaa gtagaacaga caccccttca agaagctttg      420

aatcaactga tgagacaatt gcagagaaaa gatccaagtg ctttcttttc atttcctgtg      480

actgatttta ttgctcctgg ctactccatg atcattaaac acccaatgga ttttagtacc      540

atgaaagaaa agatcaagaa caatgactat cagtccatag aagaactaaa ggataacttc      600

aaactaatgt gtactaatgc catgatttac aataaaccag agaccattta ttataaagct      660

gcaaagaagc tgttgcactc aggaatgaaa attcttagcc aggaaagaat tcagagcctg      720

aagcagagca tagacttcat ggctgacttg cagaaaactc gaaagcagaa agatggaaca      780

gacacctcac agagtgggga ggacggaggc tgctggcaga gagagagaga ggactctgga      840

gatgccgaag cacacgcctt caagagtccc agcaaagaaa ataaaaagaa agacaaagat      900

atgcttgaag ataagtttaa aagcaataat ttagagagag agcaggagca gcttgaccgc      960

atcgtgaagg aatctggagg aaagctgacc aggcggcttg tgaacagtca gtgcgaattt     1020

gaaagaagaa aaccagatgg aacaacgacg ttgggacttc tccatcctgt ggatcccatt     1080

gtaggagagc caggctactg ccctgtgaga ctgggaatga caactggaag acttcagtct     1140

ggagtgaata ctttgcaggg gttcaaagag gataaaagga acaaagtcac tccagtgtta     1200

tatttgaatt atgggcccta cagttcttat gcaccgcatt atgactccac atttgcaaat     1260

atcagcaagg atgattctga tttaatctat tcaacctatg gggaagactc tgatcttcca     1320

agtgatttca gcatccatga gtttttggcc acgtgccaag attatccgta tgtcatggca     1380

gatagtttac tggatgtttt aacaaaagga gggcattcca ggaccctaca agagatggag     1440

atgtcattgc ctgaagatga aggccatact aggacacttg acacagcaaa agaaatggag     1500

attacagaag tagagccacc agggcgtttg gactccagta ctcaagacag gctcatagcg     1560

ctgaaagcag taacaaattt tggcgttcca gttgaagttt ttgactctga agaagctgaa     1620

atattccaga agaaacttga tgagaccacc agattgctca gggaactcca ggaagcccag     1680

aatgaacgtt tgagcaccag accccctccg aacatgatct gtctcttggg tccctcatac     1740

agagaaatgc atcttgctga acaagtgacc aataatctta aagaacttgc acagcaagta     1800

actccaggtg atatcgtaag cacgtatgga gttcgaaaag caatggggat ttccattcct     1860

tcccccgtca tggaaaacaa ctttgtggat ttgacagaag acactgaaga acctaaaaag     1920

acggatgttg ctgagtgtgg acctggtgga agttga                               1956


<210>  16
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  16
atgagccacg ggaagggaac cgacatgctc ccggagatcg ccgccgccgt gggcttcctc       60

tccagcctcc tgaggacccg gggctgcgtg agcgagcaga ggcttaaggt cttcagcggg      120

gcgctccagg aggcactcac agagcactac aaacaccact ggtttcccga aaagccgtcc      180

aagggctccg gctaccgctg cattcgcatc aaccacaaga tggaccccat catcagcagg      240

gtggccagcc agatcggact cagccagccc cagctgcacc agctgctgcc cagcgagctg      300

accctgtggg tggaccccta tgaggtgtcc taccgcattg gggaggacgg ctccatctgc      360

gtcttgtacg aggaggcccc actggccgcc tcctgtgggc tcctcacctg caagaaccaa      420

gtgctgctgg gccggagcag cccctccaag aactacgtga tggcagtctc cagctag         477


<210>  17
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  17
atggttctgc tgcacgtgaa gcggggcgac gagagccagt tcctgctgca ggcgcctggg       60

agtaccgagc tggaggagct cacggtgcag gtggcccggg tctataatgg gcggctcaag      120

gtgcagcgcc tctgctcaga aatggaagaa ttagccgaac atggcatatt tctccctcct      180

aatatgcaag gactgaccga tgatcagatt gaagaattga aattgaagga tgaatggggt      240

gaaaaatgcg tacccagcgg aggtgcagtg tttaaaaagg atgatattgg acgaaggaat      300

gggcaagctc caaatgagaa gatgaagcaa gtgttaaaga agactataga agaagccaaa      360

gcaataatat ctaagaaaca agtggaagcc ggtgtctgtg ttaccatgga gatggtgaaa      420

gatgccttgg accagcttcg aggcgcggtg atgattgttt accccatggg gttgccaccg      480

tatgatccca tccgcatgga gtttgaaaat aaggaagact tgtcgggaac acaggcaggg      540

ctcaacgtca ttaaagaggc agaggcgcag ctgtggtggg cagccaagga gctgagaaga      600

acgaagaagc tttcagacta cgtggggaag aatgaaaaaa ccaaaattat cgccaagatt      660

cagcaaaggg gacagggagc tccagcccga gagcctatta ttagcagtga ggagcagaag      720

cagctgatgc tgtactatca cagaagacaa gaggagctca agagattgga agaaaatgat      780

gatgatgcct atttaaactc accatgggcg gataacactg ctttgaaaag acattttcat      840

ggagtgaaag acataaagtg gagaccaaga tga                                   873


<210>  18
<211>  228
<212>  DNA
<213>  Homo sapiens

<400>  18
atggagagaa gctttgtatg gctgtcatgc ttagacagtg attcctgcaa cttgaccttc       60

aggctgggag aggtggagag ccatgcctgt tctccttcct tgctatggaa tttgctgaca      120

caatatcttc cgcctggtgc tgggcatatc ctaagaactt acaactttcc tgtattatcc      180

tgtgtgagca gctgtcacct tattggggga aaaatgcctg aaaattag                   228


<210>  19
<211>  870
<212>  DNA
<213>  Homo sapiens

<400>  19
atggagctgc tgtgccacga ggtggacccg gtccgcaggg ccgtgcggga ccgcaacctg       60

ctccgagacg accgcgtcct gcagaacctg ctcaccatcg aggagcgcta ccttccgcag      120

tgctcctact tcaagtgcgt gcagaaggac atccaaccct acatgcgcag aatggtggcc      180

acctggatgc tggaggtctg tgaggaacag aagtgcgaag aagaggtctt ccctctggcc      240

atgaattacc tggaccgttt cttggctggg gtcccgactc cgaagtccca tctgcaactc      300

ctgggtgctg tctgcatgtt cctggcctcc aaactcaaag agaccagccc gctgaccgcg      360

gagaagctgt gcatttacac cgacaactcc atcaagcctc aggagctgct ggagtgggaa      420

ctggtggtgc tggggaagtt gaagtggaac ctggcagctg tcactcctca tgacttcatt      480

gagcacatct tgcgcaagct gccccagcag cgggagaagc tgtctctgat ccgcaagcat      540

gctcagacct tcattgctct gtgtgccacc gactttaagt ttgccatgta cccaccgtcg      600

atgatcgcaa ctggaagtgt gggagcagcc atctgtgggc tccagcagga tgaggaagtg      660

agctcgctca cttgtgatgc cctgactgag ctgctggcta agatcaccaa cacagacgtg      720

gattgtctca aagcttgcca ggagcagatt gaggcggtgc tcctcaatag cctgcagcag      780

taccgtcagg accaacgtga cggatccaag tcggaggatg aactggacca agccagcacc      840

cctacagacg tgcgggatat cgacctgtga                                       870


<210>  20
<211>  2229
<212>  DNA
<213>  Homo sapiens

<400>  20
atggacaagt tttggtggca cgcagcctgg ggactctgcc tcgtgccgct gagcctggcg       60

cagatcgatt tgaatataac ctgccgcttt gcaggtgtat tccacgtgga gaaaaatggt      120

cgctacagca tctctcggac ggaggccgct gacctctgca aggctttcaa tagcaccttg      180

cccacaatgg cccagatgga gaaagctctg agcatcggat ttgagacctg caggtatggg      240

ttcatagaag ggcacgtggt gattccccgg atccacccca actccatctg tgcagcaaac      300

aacacagggg tgtacatcct cacatccaac acctcccagt atgacacata ttgcttcaat      360

gcttcagctc cacctgaaga agattgtaca tcagtcacag acctgcccaa tgcctttgat      420

ggaccaatta ccataactat tgttaaccgt gatggcaccc gctatgtcca gaaaggagaa      480

tacagaacga atcctgaaga catctacccc agcaacccta ctgatgatga cgtgagcagc      540

ggctcctcca gtgaaaggag cagcacttca ggaggttaca tcttttacac cttttctact      600

gtacacccca tcccagacga agacagtccc tggatcaccg acagcacaga cagaatccct      660

gctaccactt tgatgagcac tagtgctaca gcaactgaga cagcaaccaa gaggcaagaa      720

acctgggatt ggttttcatg gttgtttcta ccatcagagt caaagaatca tcttcacaca      780

acaacacaaa tggctggtac gtcttcaaat accatctcag caggctggga gccaaatgaa      840

gaaaatgaag atgaaagaga cagacacctc agtttttctg gatcaggcat tgatgatgat      900

gaagatttta tctccagcac catttcaacc acaccacggg cttttgacca cacaaaacag      960

aaccaggact ggacccagtg gaacccaagc cattcaaatc cggaagtgct acttcagaca     1020

accacaagga tgactgatgt agacagaaat ggcaccactg cttatgaagg aaactggaac     1080

ccagaagcac accctcccct cattcaccat gagcatcatg aggaagaaga gaccccacat     1140

tctacaagca caatccaggc aactcctagt agtacaacgg aagaaacagc tacccagaag     1200

gaacagtggt ttggcaacag atggcatgag ggatatcgcc aaacacccaa agaagactcc     1260

cattcgacaa cagggacagc tgcagcctca gctcatacca gccatccaat gcaaggaagg     1320

acaacaccaa gcccagagga cagttcctgg actgatttct tcaacccaat ctcacacccc     1380

atgggacgag gtcatcaagc aggaagaagg atggatatgg actccagtca tagtataacg     1440

cttcagccta ctgcaaatcc aaacacaggt ttggtggaag atttggacag gacaggacct     1500

ctttcaatga caacgcagca gagtaattct cagagcttct ctacatcaca tgaaggcttg     1560

gaagaagata aagaccatcc aacaacttct actctgacat caagcaatag gaatgatgtc     1620

acaggtggaa gaagagaccc aaatcattct gaaggctcaa ctactttact ggaaggttat     1680

acctctcatt acccacacac gaaggaaagc aggaccttca tcccagtgac ctcagctaag     1740

actgggtcct ttggagttac tgcagttact gttggagatt ccaactctaa tgtcaatcgt     1800

tccttatcag gagaccaaga cacattccac cccagtgggg ggtcccatac cactcatgga     1860

tctgaatcag atggacactc acatgggagt caagaaggtg gagcaaacac aacctctggt     1920

cctataagga caccccaaat tccagaatgg ctgatcatct tggcatccct cttggccttg     1980

gctttgattc ttgcagtttg cattgcagtc aacagtcgaa gaaggtgtgg gcagaagaaa     2040

aagctagtga tcaacagtgg caatggagct gtggaggaca gaaagccaag tggactcaac     2100

ggagaggcca gcaagtctca ggaaatggtg catttggtga acaaggagtc gtcagaaact     2160

ccagaccagt ttatgacagc tgatgagaca aggaacctgc agaatgtgga catgaagatt     2220

ggggtgtaa                                                             2229


<210>  21
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  21
atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc       60

cattcaggtc atagcctgca gtgctacaac tgtcctaacc caactgctga ctgcaaaaca      120

gccgtcaatt gttcatctga ttttgatgcg tgtctcatta ccaaagctgg gttacaagtg      180

tataacaagt gttggaagtt tgagcattgc aatttcaacg acgtcacaac ccgcttgagg      240

gaaaatgagc taacgtacta ctgctgcaag aaggacctgt gtaactttaa cgaacagctt      300

gaaaatggtg ggacatcctt atcagagaaa acagttcttc tgctggtgac tccatttctg      360

gcagcagcct ggagccttca tccctaa                                          387


<210>  22
<211>  1785
<212>  DNA
<213>  Homo sapiens

<400>  22
atggcagcgg agtcagggga actaatcggg gcttgtgagt tcatgaaaga tcggttatat       60

tttgctactt taaggaatag accaaaaagc acagtaaata cccactattt ctccatcgat      120

gaggagctgg tctatgaaaa tttctatgca gattttggac cgctgaactt ggcaatggtg      180

tacagatatt gctgcaaact aaacaagaaa ctaaaatcat acagtttgtc aagaaagaaa      240

atagtgcact acacctgttt tgaccaacgg aaaagagcaa atgcagcatt tttgataggt      300

gcctatgcag taatctattt aaagaagaca ccagaagaag cctacagagc actcctgtct      360

ggctcaaacc ccccctatct tccattcagg gatgcttcct ttggaaattg cacttacaat      420

ctcaccattc tcgactgttt gcagggaatc agaaagggat tacaacatgg attttttgac      480

tttgagacat ttgatgtgga tgaatatgaa cattatgagc gagttgaaaa tggtgacttc      540

aactggattg ttccaggaaa atttttagca tttagtggac cacatcctaa aagcaaaatt      600

gagaatggtt atcctcttca cgcccctgaa gcctactttc cttatttcaa aaagcataat      660

gtgactgcag ttgtgaggct aaacaaaaag atttatgagg caaagcgctt cacagacgct      720

ggcttcgagc actatgacct cttcttcata gatggcagca cacccagtga caacatcgtg      780

cgaaggttcc tgaacatctg tgagaacacc gaaggggcca tcgccgttca ctgcaaagct      840

ggtcttggaa gaacagggac attgatagcc tgttatgtaa tgaaacacta caggtttaca      900

catgctgaaa taattgcttg gattagaata tgccggccag gctctattat aggaccccag      960

cagcacttcc tggaagaaaa acaagcatcg ttgtgggtcc aaggagacat tttccgatcc     1020

aaactgaaaa atcgaccatc cagtgaagga agtattaata aaattctttc tggcctagat     1080

gatatgtcta ttggtggaaa tctttcaaaa acacaaaaca tggaacgatt tggagaggat     1140

aacttagaag atgatgatgt ggaaatgaaa aatggtataa cccagggaga caaactacgt     1200

gccttaaaaa gtcagagaca gccacgtacc tcaccatcct gtgcatttag gtcagatgat     1260

acaaaaggac atccaagagc agtgtcccag cctttcagat taagttcatc cctgcaagga     1320

tctgcagtta ctttgaagac atcaaaaatg gcactgtccc cttcagcaac ggccaagagg     1380

atcaacagaa cttctttgtc ttcgggtgcc actgtaagaa gcttttccat aaactcccgg     1440

ctagccagtt ctctagggaa cttgaatgct gcaacagatg atccagagaa caaaaagacc     1500

tcctcatcct ctaaggcagg cttcacagcc agcccgttta ccaacctctt gaatggcagc     1560

tcccagccaa ctaccagaaa ttaccctgag ctcaacaata atcagtacaa cagaagcagc     1620

aacagcaacg ggggcaacct gaacagcccc ccaggccccc acagcgccaa gacagaggag     1680

cacaccacca tcctccgacc ctcctacacc gggctttctt cttcttcagc gagattcctg     1740

agccgttcta tcccttccct tcagtctgaa tatgttcatt actaa                     1785


<210>  23
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  23
atgggggcga cgggggcggc ggagccgctg caatccgtgc tgtgggtgaa gcagcagcgc       60

tgcgccgtga gcctggagcc cgcgcgggct ctgctgcgct ggtggcggag cccggggccc      120

ggagccggcg cccccggcgc ggatgcctgc tctgtgcctg tatctgagat catcgccgtt      180

gaggaaacag acgttcacgg gaaacatcaa ggcagtggaa aatggcagaa aatggaaaag      240

ccttacgctt ttacagttca ctgtgtaaag agagcacgac ggcaccgctg gaagtgggcg      300

caggtgactt tctggtgtcc agaggagcag ctgtgtcact tgtggctgca gaccctgcgg      360

gagatgctgg agaagctgac gtccagacca aagcatttac tggtatttat caacccgttt      420

ggaggaaaag gacaaggcaa gcggatatat gaaagaaaag tggcaccact gttcacctta      480

gcctccatca ccactgacat catcgttact gaacatgcta atcaggccaa ggagactctg      540

tatgagatta acatagacaa atacgacggc atcgtctgtg tcggcggaga tggtatgttc      600

agcgaggtgc tgcacggtct gattgggagg acgcagagga gcgccggggt cgaccagaac      660

cacccccggg ctgtgctggt ccccagtagc ctccggattg gaatcattcc cgcagggtca      720

acggactgcg tgtgttactc caccgtgggc accagcgacg cagaaacctc ggcgctgcat      780

atcgttgttg gggactcgct ggccatggat gtgtcctcag tccaccacaa cagcacactc      840

cttcgctact ccgtgtccct gctgggctac ggcttctacg gggacatcat caaggacagt      900

gagaagaaac ggtggttggg tcttgccaga tacgactttt caggtttaaa gaccttcctc      960

tcccaccact gctatgaagg gacagtgtcc ttcctccctg cacaacacac ggtgggatct     1020

ccaagggata ggaagccctg ccgggcagga tgctttgttt gcaggcaaag caagcagcag     1080

ctggaggagg agcagaagaa agcactgtat ggtttggaag ctgcggagga cgtggaggag     1140

tggcaagtcg tctgtgggaa gtttctggcc atcaatgcca caaacatgtc ctgtgcttgt     1200

cgccggagcc ccaggggcct ctccccggct gcccacttgg gagacgggtc ttctgacctc     1260

atcctcatcc ggaaatgctc caggttcaat tttctgagat ttctcatcag gcacaccaac     1320

cagcaggacc agtttgactt cacttttgtt gaagtttatc gcgtcaagaa attccagttt     1380

acgtcgaagc acatggagga tgaggacagc gacctcaagg agggggggaa gaagcgcttt     1440

gggcacattt gcagcagcca cccctcctgc tgctgcaccg tctccaacag ctcctggaac     1500

tgcgacgggg aggtcctgca cagccctgcc atcgaggtca gagtccactg ccagctggtt     1560

cgactctttg cacgaggaat tgaagagaat ccgaagccag actcacacag ctga           1614


<210>  24
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  24
atggcggcag gcgccggggc cgggtccgcg ccgcgctggc tgagggcgct gagcgagccg       60

ctgagcgcgg cgcagctgcg gcgactggag gagcaccgct acagcgcggc gggcgtctcg      120

ctgctcgagc cgccgctgca gctctactgg acctggctgc tccagtggat cccgctctgg      180

atggccccca actccatcac cctgctgggg ctcgccgtca acgtggtcac cacgctcgtg      240

ctcatctcct actgtcccac ggccaccgaa gaggcaccat actggacata ccttttatgt      300

gcactgggac tttttattta ccagtcactg gatgctattg atgggaaaca agccagaaga      360

acaaactctt gttccccttt aggggagctc tttgaccatg gctgtgactc tctttccaca      420

gtatttatgg cagtgggagc ttcaattgcc gctcgcttag gaacttatcc tgactggttt      480

tttttctgct cttttattgg gatgtttgtg ttttattgcg ctcattggca gacttatgtt      540

tcaggcatgt tgagatttgg aaaagtggat gtaactgaaa ttcagatagc tttagtgatt      600

gtctttgtgt tgtctgcatt tggaggagca acaatgtggg actatacgat tcctattcta      660

gaaataaaat tgaagatcct tccagttctt ggatttctag gtggagtaat attttcctgt      720

tcaaattatt tccatgttat cctccatggt ggtgttggca agaatggatc cactatagca      780

ggcaccagtg tcttgtcacc tggactccac ataggactaa ttattatact ggcaataatg      840

atctataaaa agtcagcaac tgatgtgttt gaaaagcatc cttgtcttta tatcctaatg      900

tttggatgtg tctttgctaa agtctcacaa aaattagtgg tagctcacat gaccaaaagt      960

gaactatatc ttcaagacac tgtctttttg gggccaggtc ttttgttttt agaccagtac     1020

tttaataact ttatagacga atatgttgtt ctatggatgg caatggtgat ttcttcattt     1080

gatatggtga tatactttag tgctttgtgc ctgcaaattt caagacacct tcatctaaat     1140

atattcaaga ctgcatgtca tcaagcacct gaacaggttc aagttctttc ttcaaagagt     1200

catcagaata acatggattg a                                               1221


<210>  25
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  25
atgaattcat ctaaatcatc tgaaacacaa tgcacagaga gaggatgctt ctcttcccaa       60

atgttcttat ggactgttgc tgggatcccc atcctatttc tcagtgcctg tttcatcacc      120

agatgtgttg tgacatttcg catctttcaa acctgtgatg agaaaaagtt tcagctacct      180

gagaatttca cagagctctc ctgctacaat tatggatcag gttcagtcaa gaattgttgt      240

ccattgaact gggaatattt tcaatccagc tgctacttct tttctactga caccatttcc      300

tgggcgttaa gtttaaagaa ctgctcagcc atgggggctc acctggtggt tatcaactca      360

caggaggagc aggaattcct ttcctacaag aaacctaaaa tgagagagtt ttttattgga      420

ctgtcagacc aggttgtcga gggtcagtgg caatgggtgg acggcacacc tttgacaaag      480

tctctgagct tctgggatgt aggggagccc aacaacatag ctaccctgga ggactgtgcc      540

accatgagag actcttcaaa cccaaggcaa aattggaatg atgtaacctg tttcctcaat      600

tattttcgga tttgtgaaat ggtaggaata aatcctttga acaaaggaaa atctctttaa      660


<210>  26
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  26
atgatgaaga ctctgctgct gtttgtgggg ctgctgctga cctgggagag tgggcaggtc       60

ctgggggacc agacggtctc agacaatgag ctccaggaaa tgtccaatca gggaagtaag      120

tacgtcaata aggaaattca aaatgctgtc aacggggtga aacagataaa gactctcata      180

gaaaaaacaa acgaagagcg caagacactg ctcagcaacc tagaagaagc caagaagaag      240

aaagaggatg ccctaaatga gaccagggaa tcagagacaa agctgaagga gctcccagga      300

gtgtgcaatg agaccatgat ggccctctgg gaagagtgta agccctgcct gaaacagacc      360

tgcatgaagt tctacgcacg cgtctgcaga agtggctcag gcctggttgg ccgccagctt      420

gaggagttcc tgaaccagag ctcgcccttc tacttctgga tgaatggtga ccgcatcgac      480

tccctgctgg agaacgaccg gcagcagacg cacatgctgg atgtcatgca ggaccacttc      540

agccgcgcgt ccagcatcat agacgagctc ttccaggaca ggttcttcac ccgggagccc      600

caggatacct accactacct gcccttcagc ctgccccacc ggaggcctca cttcttcttt      660

cccaagtccc gcatcgtccg cagcttgatg cccttctctc cgtacgagcc cctgaacttc      720

cacgccatgt tccagccctt ccttgagatg atacacgagg ctcagcaggc catggacatc      780

cacttccata gcccggcctt ccagcacccg ccaacagaat tcatacgaga aggcgacgat      840

gaccggactg tgtgccggga gatccgccac aactccacgg gctgcctgcg gatgaaggac      900

cagtgtgaca agtgccggga gatcttgtct gtggactgtt ccaccaacaa cccctcccag      960

gctaagctgc ggcgggagct cgacgaatcc ctccaggtcg ctgagaggtt gaccaggaaa     1020

tacaacgagc tgctaaagtc ctaccagtgg aagatgctca acacctcctc cttgctggag     1080

cagctgaacg agcagtttaa ctgggtgtcc cggctggcaa acctcacgca aggcgaagac     1140

cagtactatc tgcgggtcac cacggtggct tcccacactt ctgactcgga cgttccttcc     1200

ggtgtcactg aggtggtcgt gaagctcttt gactctgatc ccatcactgt gacggtccct     1260

gtagaagtct ccaggaagaa ccctaaattt atggagaccg tggcggagaa agcgctgcag     1320

gaataccgca aaaagcaccg ggaggagtga                                      1350


<210>  27
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  27
atgagcagca atgagtgctt caagtgtgga cgatctggcc actgggcccg ggaatgtcct       60

actggtggag gccgtggtcg tggaatgaga agccgtggca gaggtggttt tacctcggat      120

agaggtttcc agtttgtttc ctcgtctctt ccagacattt gttatcgctg tggtgagtct      180

ggtcatcttg ccaaggattg tgatcttcag gaggatgcct gctataactg cggtagaggt      240

ggccacattg ccaaggactg caaggagccc aagagagagc gagagcaatg ctgctacaac      300

tgtggcaaac caggccatct ggctcgtgac tgcgaccatg cagatgagca gaaatgctat      360

tcttgtggag aattcggaca cattcaaaaa gactgcacca aagtgaagtg ctataggtgt      420

ggtgaaactg gtcatgtagc catcaactgc agcaagacaa gtgaagtcaa ctgttaccgc      480

tgtggcgagt cagggcacct tgcacgggaa tgcacaattg aggctacagc ctaa            534


<210>  28
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  28
atgaggttcc ggttctgtgg tgatctggac tgtcccgact gggtcctggc agaaatcagc       60

acgctggcca agatgtcctc tgtgaagttg cggctgctct gcagccaggt actaaaggag      120

ctgctgggac aggggattga ttatgagaag atcctgaagc tcacggctga cgccaagttt      180

gagtcaggcg atgtgaaggc cacagtggca gtgctgagtt tcatcctctc cagtgcggcc      240

aagcacagtg tcgatggcga atccttgtcc agtgaactgc agcagctggg gctgcccaaa      300

gagcacgcgg ccagcctgtg ccgctgttat gaggagaagc aaagcccctt gcagaagcac      360

ttgcgggtct gcagcctacg catgaatagg ttggcaggtg tgggctggcg ggtggactac      420

accctgagct ccagcctgct gcaatccgtg gaagagccca tggtgcacct gcggctggag      480

gtggcagctg ccccagggac cccagcccag cctgttgcca tgtccctctc agcagacaag      540

ttccaggtcc tcctggcaga actgaagcag gcccagaccc tgatgagctc cctgggctga      600


<210>  29
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  29
atggcagctc ggactggtca tacggccttg agaagggtag tctcgggatg ccgtccgaag       60

tcggcgacag cggccggggc gcaggcgccc gtgcggaatg gcagatattt agcttcctgt      120

ggtatactga tgagcagaac tcttccacta catacctcaa ttttgcctaa ggagatatgt      180

gcacgaactt tcttcaaaat cactgcacca ttaataaaca aaaggaaaga atattcagag      240

agaagaattt taggatattc aatgcaggaa atgtatgatg tagtatcggg agtggaggat      300

tacaagcatt ttgttccttg gtgcaaaaaa tcagatgtta tatcaaagag atctggatat      360

tgtaaaacaa gattagaaat tggatttcca cctgtgttgg agcgatatac atcagtagta      420

accttggtga aacctcattt agtaaaggca tcttgtactg atgggagact tttcaatcat      480

ttggagacta tttggcgttt tagcccaggt cttcctggct acccaagaac ttgtaccttg      540

gatttttcaa tttcttttga atttcgatca cttctacatt cccagcttgc cacactcttt      600

tttgatgaag ttgtgaagca gatggtagct gcctttgaaa gaagagcatg taagctgtat      660

ggtccagaaa caaatatacc tcgggagtta atgcttcatg aagtccatca cacataa         717


<210>  30
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  30
atggcttcaa ggttacttcg cggagctgga acgctggccg cgcaggccct gagggctcgc       60

ggccccagtg gcgcggccgc gatgcgctcc atggcatctg gaggtggtgt tcccactgat      120

gaagagcagg cgactgggtt ggagagggag atcatgctgg ctgcaaagaa gggactggac      180

ccatacaatg tactggcccc aaagggagct tcaggcacca gggaagaccc taatttagtc      240

ccctccatct ccaacaagag aatagtaggc tgcatctgtg aagaggacaa taccagcgtc      300

gtctggtttt ggctgcacaa aggcgaggcc cagcgatgcc cccgctgtgg agcccattac      360

aagctggtgc cccagcagct ggcacactga                                       390


<210>  31
<211>  1431
<212>  DNA
<213>  Homo sapiens

<400>  31
atggttggtg ccatgtggaa ggtgattgtt tcgctggtcc tgttgatgcc tggcccctgt       60

gatgggctgt ttcgctccct atacagaagt gtttccatgc cacctaaggg agactcagga      120

cagccattat ttctcacccc ttacattgaa gctgggaaga tccaaaaagg aagagaattg      180

agtttggtcg gccctttccc aggactgaac atgaagagtt atgccggctt cctcaccgtg      240

aataagactt acaacagcaa cctcttcttc tggttcttcc cagctcagat acagccagaa      300

gatgccccag tagttctctg gctacagggt gggccgggag gttcatccat gtttggactc      360

tttgtggaac atgggcctta tgttgtcaca agtaacatga ccttgcgtga cagagacttc      420

ccctggacca caacgctctc catgctttac attgacaatc cagtgggcac aggcttcagt      480

tttactgatg atacccacgg atatgcagtc aatgaggacg atgtagcacg ggatttatac      540

agtgcactaa ttcagttttt ccagatattt cctgaatata aaaataatga cttttatgtc      600

actggggagt cttatgcagg gaaatatgtg ccagccattg cacacctcat ccattccctc      660

aaccctgtga gagaggtgaa gatcaacctg aacggaattg ctattggaga tggatattct      720

gatcccgaat caattatagg gggctatgca gaattcctgt accaaattgg cttgttggat      780

gagaagcaaa aaaagtactt ccagaagcag tgccatgaat gcatagaaca catcaggaag      840

cagaactggt ttgaggcctt tgaaatactg gataaactac tagatggcga cttaacaagt      900

gatccttctt acttccagaa tgttacagga tgtagtaatt actataactt tttgcggtgc      960

acggaacctg aggatcagct ttactatgtg aaatttttgt cactcccaga ggtgagacaa     1020

gccatccacg tggggaatca gacttttaat gatggaacta tagttgaaaa gtacttgcga     1080

gaagatacag tacagtcagt taagccatgg ttaactgaaa tcatgaataa ttataaggtt     1140

ctgatctaca atggccaact ggacatcatc gtggcagctg ccctgacaga gcgctccttg     1200

atgggcatgg actggaaagg atcccaggaa tacaagaagg cagaaaaaaa agtttggaag     1260

atctttaaat ctgacagtga agtggctggt tacatccggc aagcgggtga cttccatcag     1320

gtaattattc gaggtggagg acatatttta ccctatgacc agcctctgag agcttttgac     1380

atgattaatc gattcattta tggaaaagga tgggatcctt atgttggata a              1431


<210>  32
<211>  816
<212>  DNA
<213>  Homo sapiens

<400>  32
atggaacacg gctccatcat cacccaggcg cggagggaag acgccctggt gctcaccaag       60

caaggcctgg tctccaagtc ctctcctaag aagcctcgtg gacgtaacat cttcaaggcc      120

cttttctgct gttttcgcgc ccagcatgtt ggccagtcaa gttcctccac tgagctcgct      180

gcgtataagg aggaagcaaa caccattgct aagtcggatc tgctccagtg tctccagtac      240

cagttctacc agatcccagg gacctgcctg ctcccagagg tgacagagga agatcaagga      300

aggatctgtg tggtcattga cctcgatgaa acccttgtgc atagctcctt taagccaatc      360

aacaatgctg acttcatagt gcctatagag attgagggga ccactcacca ggtgtatgtg      420

ctcaagaggc cttatgtgga tgagttcctg agacgcatgg gggaactctt tgaatgtgtt      480

ctcttcactg ccagcctggc caagtatgcc gaccctgtga cagacctgct ggaccggtgt      540

ggggtgttcc gggcccgcct attccgtgag tcttgcgtgt tccaccaggg ctgctacgtc      600

aaggacctca gccgcctggg gagggacctg agaaagaccc tcatcctgga caactcgcct      660

gcttcttaca tattccaccc cgagaatgca gtgcctgtgc agtcctggtt tgatgacatg      720

gcagacactg agttgctgaa cctgatccca atctttgagg agctgagcgg agcagaggac      780

gtctacacca gccttgggca gctgcgggcc ccttag                                816


<210>  33
<211>  1497
<212>  DNA
<213>  Homo sapiens

<400>  33
atgacttcca gtccccgggc gcctcctgga gagcaaggac gcgggggagc agagatgatc       60

cgagccgcgc cgccgccgct gttcctgctg ctgctgctgc tgctgctgct agtgtcctgg      120

gcgtcccgag gcgaggcagc ccccgaccag gacgagatcc agcgcctccc cgggctggcc      180

aagcagccgt ctttccgcca gtactccggc tacctcaaag gctccggctc caagcacctc      240

cactactggt ttgtggagtc ccagaaggat cccgagaaca gccctgtggt gctttggctc      300

aatgggggtc ccggctgcag ctcactagat gggctcctca cagagcatgg ccccttcctg      360

gtccagccag atggtgtcac cctggagtac aacccctatt cttggaatct gattgccaat      420

gtgttatacc tggagtcccc agctggggtg ggcttctcct actccgatga caagttttat      480

gcaactaatg acactgaggt cgcccagagc aattttgagg cccttcaaga tttcttccgc      540

ctctttccgg agtacaagaa caacaaactt ttcctgaccg gggagagcta tgctggcatc      600

tacatcccca ccctggccgt gctggtcatg caggatccca gcatgaacct tcaggggctg      660

gctgtgggca atggactctc ctcctatgag cagaatgaca actccctggt ctactttgcc      720

tactaccatg gccttctggg gaacaggctt tggtcttctc tccagaccca ctgctgctct      780

caaaacaagt gtaacttcta tgacaacaaa gacctggaat gcgtgaccaa tcttcaggaa      840

gtggcccgca tcgtgggcaa ctctggcctc aacatctaca atctctatgc cccgtgtgct      900

ggaggggtgc ccagccattt taggtatgag aaggacactg ttgtggtcca ggatttgggc      960

aacatcttca ctcgcctgcc actcaagcgg atgtggcatc aggcactgct gcgctcaggg     1020

gataaagtgc gcatggaccc cccctgcacc aacacaacag ctgcttccac ctacctcaac     1080

aacccgtacg tgcggaaggc cctcaacatc ccggagcagc tgccacaatg ggacatgtgc     1140

aactttctgg taaacttaca gtaccgccgt ctctaccgaa gcatgaactc ccagtatctg     1200

aagctgctta gctcacagaa ataccagatc ctattatata atggagatgt agacatggcc     1260

tgcaatttca tgggggatga gtggtttgtg gattccctca accagaagat ggaggtgcag     1320

cgccggccct ggttagtgaa gtacggggac agcggggagc agattgccgg cttcgtgaag     1380

gagttctccc acatcgcctt tctcacgatc aagggcgccg gccacatggt tcccaccgac     1440

aagcccctcg ctgccttcac catgttctcc cgcttcctga acaagcagcc atactga        1497


<210>  34
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  34
atgggtgctg ggccctcctt gctgctcgcc gccctcctgc tgcttctctc cggcgacggc       60

gccgtgcgct gcgacacacc tgccaactgc acctatcttg acctgctggg cacctgggtc      120

ttccaggtgg gctccagcgg ttcccagcgc gatgtcaact gctcggttat gggaccacaa      180

gaaaaaaaag tagtggtgta ccttcagaag ctggatacag catatgatga ccttggcaat      240

tctggccatt tcaccatcat ttacaaccaa ggctttgaga ttgtgttgaa tgactacaag      300

tggtttgcct tttttaagta taaagaagag ggcagcaagg tgaccactta ctgcaacgag      360

acaatgactg ggtgggtgca tgatgtgttg ggccggaact gggcttgttt caccggaaag      420

aaggtgggaa ctgcctctga gaatgtgtat gtcaacatag cacaccttaa gaattctcag      480

gaaaagtatt ctaataggct ctacaagtat gatcacaact ttgtgaaagc tatcaatgcc      540

attcagaagt cttggactgc aactacatac atggaatatg agactcttac cctgggagat      600

atgattagga gaagtggtgg ccacagtcga aaaatcccaa ggcccaaacc tgcaccactg      660

actgctgaaa tacagcaaaa gattttgcat ttgccaacat cttgggactg gagaaatgtt      720

catggtatca attttgtcag tcctgttcga aaccaagcat cctgtggcag ctgctactca      780

tttgcttcta tgggtatgct agaagcgaga atccgtatac taaccaacaa ttctcagacc      840

ccaatcctaa gccctcagga ggttgtgtct tgtagccagt atgctcaagg ctgtgaaggc      900

ggcttcccat accttattgc aggaaagtac gcccaagatt ttgggctggt ggaagaagct      960

tgcttcccct acacaggcac tgattctcca tgcaaaatga aggaagactg ctttcgttat     1020

tactcctctg agtaccacta tgtaggaggt ttctatggag gctgcaatga agccctgatg     1080

aagcttgagt tggtccatca tgggcccatg gcagttgctt ttgaagtata tgatgacttc     1140

ctccactaca aaaaggggat ctaccaccac actggtctaa gagacccttt caaccccttt     1200

gagctgacta atcatgctgt tctgcttgtg ggctatggca ctgactcagc ctctgggatg     1260

gattactgga ttgttaaaaa cagctggggc accggctggg gtgagaatgg ctacttccgg     1320

atccgcagag gaactgatga gtgtgcaatt gagagcatag cagtggcagc cacaccaatt     1380

cctaaattgt ag                                                         1392


<210>  35
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  35
atgtgggcca cgctgccgct gctctgcgcc ggggcctggc tcctgggagt ccccgtctgc       60

ggtgccgccg aactgtgcgt gaactcctta gagaagtttc acttcaagtc atggatgtct      120

aagcaccgta agacctacag tacggaggag taccaccaca ggctgcagac gtttgccagc      180

aactggagga agataaacgc ccacaacaat gggaaccaca catttaaaat ggcactgaac      240

caattttcag acatgagctt tgctgaaata aaacacaagt atctctggtc agagcctcag      300

aattgctcag ccaccaaaag taactacctt cgaggtactg gtccctaccc accttccgtg      360

gactggcgga aaaaaggaaa ttttgtctca cctgtgaaaa atcagggtgc ctgcggcagt      420

tgctggactt tctccaccac tggggccctg gagtctgcga tcgccatcgc aaccggaaag      480

atgctgtcct tggcggaaca gcagctggtg gactgcgccc aggacttcaa taatcacggc      540

tgccaagggg gtctccccag ccaggctttc gagtatatcc tgtacaacaa ggggatcatg      600

ggtgaagaca cctaccccta ccagggcaag gatggttatt gcaagttcca acctggaaag      660

gccatcggct ttgtcaagga tgtagccaac atcacaatct atgacgagga agcgatggtg      720

gaggctgtgg ccctctacaa ccctgtgagc tttgcctttg aggtgactca ggacttcatg      780

atgtatagaa ccggcatcta ctccagtact tcctgccata aaactccaga taaagtaaac      840

catgcagtac tggctgttgg gtatggagaa aaaaatggga tcccttactg gatcgtgaaa      900

aactcttggg gtccccagtg gggaatgaac gggtacttcc tcatcgagcg cggaaagaac      960

atgtgtggcc tggctgcctg cgcctcctac cccatccctc tggtgtga                  1008


<210>  36
<211>  1713
<212>  DNA
<213>  Homo sapiens

<400>  36
atggggaact gggctgtgaa tgaggggctc tccatttttg tcattctggt ttggctgggg       60

ttgaacgtct tcctctttgt ctggtattac cgggtttatg atattccacc taagttcttt      120

tacacaagaa aacttcttgg gtcagcactg gcactggcca gggcccctgc agcctgcctg      180

aatttcaact gcatgctgat tctcttgcca gtctgtcgaa atctgctgtc cttcctcagg      240

ggttccagtg cgtgctgctc aacaagagtt cgaagacaac tggacaggaa tctcaccttt      300

cataaaatgg tggcatggat gattgcactt cactctgcga ttcacaccat tgcacatcta      360

tttaatgtgg aatggtgtgt gaatgcccga gtcaataatt ctgatcctta ttcagtagca      420

ctctctgaac ttggagacag gcaaaatgaa agttatctca attttgctcg aaagagaata      480

aagaaccctg aaggaggcct gtacctggct gtgaccctgt tggcaggcat cactggagtt      540

gtcatcacgc tgtgcctcat attaattatc acttcctcca ccaaaaccat ccggaggtct      600

tactttgaag tcttttggta cacacatcat ctctttgtga tcttcttcat tggccttgcc      660

atccatggag ctgaacgaat tgtacgtggg cagaccgcag agagtttggc tgtgcataat      720

ataacagttt gtgaacaaaa aatctcagaa tggggaaaaa taaaggaatg cccaatccct      780

cagtttgctg gaaaccctcc tatgacttgg aaatggatag tgggtcccat gtttctgtat      840

ctctgtgaga ggttggtgcg gttttggcga tctcaacaga aggtggtcat caccaaggtg      900

gtcactcacc ctttcaaaac catcgagcta cagatgaaga agaaggggtt caaaatggaa      960

gtgggacaat acatttttgt caagtgccca aaggtgtcca agctggagtg gcaccctttt     1020

acactgacat ccgcccctga ggaagacttc tttagtatcc atatccgcat cgttggggac     1080

tggacagagg ggctgttcaa tgcttgtggc tgtgataagc aggagtttca agatgcgtgg     1140

aaactaccta agatagcggt tgatgggccc tttggcactg ccagtgaaga tgtgttcagc     1200

tatgaggtgg tgatgttagt gggagcaggg attggggtca cacccttcgc atccattctc     1260

aagtcagtct ggtacaaata ttgcaataac gccaccaatc tgaagctcaa aaagatctac     1320

ttctactggc tgtgccggga cacacatgcc tttgagtggt ttgcagatct gctgcaactg     1380

ctggagagcc agatgcagga aaggaacaat gccggcttcc tcagctacaa catctacctc     1440

actggctggg atgagtctca ggccaatcac tttgctgtgc accatgatga ggagaaagat     1500

gtgatcacag gcctgaaaca aaagactttg tatggacggc ccaactggga taatgaattc     1560

aagacaattg caagtcaaca ccctaatacc agaataggag ttttcctctg tggacctgaa     1620

gccttggctg aaaccctgag taaacaaagc atctccaact ctgagtctgg ccctcgggga     1680

gtgcatttca ttttcaacaa ggaaaacttc taa                                  1713


<210>  37
<211>  1389
<212>  DNA
<213>  Homo sapiens

<400>  37
atgttggact tcgcgatctt cgccgttacc ttcttgctgg cgttggtggg agccgtgctc       60

tacctctatc cggcttccag acaagctgca ggaattccag ggattactcc aactgaagaa      120

aaagatggta atcttccaga tattgtgaat agtggaagtt tgcatgagtt cctggttaat      180

ttgcatgaga gatatgggcc tgtggtctcc ttctggtttg gcaggcgcct cgtggttagt      240

ttgggcactg ttgatgtact gaagcagcat atcaatccca ataagacatc ggaccctttt      300

gaaaccatgc tgaagtcatt attaaggtat caatctggtg gtggcagtgt gagtgaaaac      360

cacatgagga aaaaattgta tgaaaatggt gtgactgatt ctctgaagag taactttgcc      420

ctcctcctaa agctttcaga agaattatta gataaatggc tctcctaccc agagacccag      480

cacgtgcccc tcagccagca tatgcttggt tttgctatga agtctgttac acagatggta      540

atgggtagta catttgaaga tgatcaggaa gtcattcgct tccagaagaa tcatggcaca      600

gtttggtctg agattggaaa aggctttcta gatgggtcac ttgataaaaa catgactcgg      660

aaaaaacaat atgaagatgc cctcatgcaa ctggagtctg ttttaaggaa catcataaaa      720

gaacgaaaag gaaggaactt cagtcaacat attttcattg actccttagt acaagggaac      780

cttaatgacc aacagatcct agaagacagt atgatatttt ctctggccag ttgcataata      840

actgcaaaat tgtgtacctg ggcaatctgt tttttaacca cctctgaaga agttcaaaaa      900

aaattatatg aagagataaa ccaagttttt ggaaatggtc ctgttactcc agagaaaatt      960

gagcagctca gatattgtca gcatgtgctt tgtgaaactg ttcgaactgc caaactgact     1020

ccagtttctg cccagcttca agatattgaa ggaaaaattg accgatttat tattcctaga     1080

gagaccctcg tcctttatgc ccttggtgtg gtacttcagg atcctaatac ttggccatct     1140

ccacacaagt ttgatccaga tcggtttgat gatgaattag taatgaaaac tttttcctca     1200

cttggattct caggcacaca ggagtgtcca gagttgaggt ttgcatatat ggtgaccaca     1260

gtacttctta gtgtattggt gaagagactg cacctacttt ctgtggaggg acaggttatt     1320

gaaacaaagt atgaactggt aacatcatca agggaagaag cttggatcac tgtctcaaag     1380

agatattaa                                                             1389


<210>  38
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  38
atgtccgcgc acaatcgggg caccgagctc gaccttagct ggatctccaa aatacaagtg       60

aatcacccgg cagttctgag gcgtgcggaa caaatccagg ctcgcagaac cgtgaaaaag      120

gagtggcagg ctgcttggct cctgaaagct gttaccttta tagatcttac tacactttca      180

ggtgatgata catcttccaa cattcaaagg ctctgttata aagccaaata cccaatccgg      240

gaagatctct taaaagcttt aaatatgcat gataaaggca ttactacagc cgccgtttgt      300

gtttatcccg cccgggtgtg tgatgctgta aaagcactca aggctgcagg ctgtaatatc      360

cctgtggcat cagtggccgc tggatttcca gctggacaga ctcatttgaa gacacgatta      420

gaagagatca gattggctgt ggaagatgga gctacagaaa tcgacgtggt aattaacaga      480

agcttggtgc tgacaggcca gtgggaagcc ctgtatgatg agattcgtca gtttcgcaag      540

gcctgtgggg aggctcatct taaaactata ttagcgacag gagaacttgg aactcttact      600

aatgtctata aagccagtat gatagcaatg atggcaggat cagattttat taagacctct      660

actggaaaag aaacagtaaa tgccaccttc ccggtagcta tagtaatgct gcgggccatt      720

agagatttct tctggaaaac tggaaacaag atagggttta aaccagcagg aggcatccgc      780

agtgcaaagg attcccttgc ttggctctct cttgtaaagg aggagcttgg agatgagtgg      840

ctgaagccag aactctttcg aataggtgcc agtactctgc tctcggacat tgagaggcag      900

atttaccatc atgtgactgg aagatatgca gcttatcatg atcttccaat gtcttaa         957


<210>  39
<211>  3126
<212>  DNA
<213>  Homo sapiens

<400>  39
atggcgacgc cggcgggtct ggagcgctgg gttcaggacg agctgcactc ggtgttgggg       60

ctgagcgagc ggcacgtcgc ccagtttctg atcggtaccg cacagcgctg cacctctgcc      120

gaggagttcg tgcagcgcct acgagacact gataccttgg atctcagtgg gccggcccgg      180

gacttcgccc tgagactctg gaacaaggta ccacgaaagg cagtggtaga aaagccagct      240

cgggcagcag agcgagaggc ccgggccctg ctggagaaga accgatctta taggttactg      300

gaagacagtg aagagagcag tgaggagact gtgagtaggg ctggaagcag cctccagaag      360

aaacgtaaaa agcggaaaca cctcaggaag aagcgtgagg aagaagagga ggaagaggct      420

tctgagaaag ggaagaagaa aacagggggg agtaaacagc agacagagaa gccagagtcg      480

gaagatgagt gggaacggac agagcgtgaa cgccttcagg acctggagga gcgtgatgcc      540

tttgctgagc gggttcgaca gcgggacaag gatcggactc gaaatgtcct ggaacggtca      600

gacaagaagg cttatgaaga ggctcagaag cgcctcaaga tggccgagga agaccggaag      660

gccatggtcc ctgagctgcg gaagaaatct cgccgagagt acctggctaa gcgggagcga      720

gagaagcttg aggacctgga ggcggagctg gctgatgagg agttcctttt tggggacgtg      780

gagctgagcc ggcacgagcg gcaggagctc aaatataagc ggcgagtgcg ggatctcgcc      840

cgggagtacc gggcagctgg ggagcaggag aagctggagg ccaccaatcg ctaccacatg      900

cccaaggaaa cccgaggaca gccagcccga gctgtggatc tagtggagga ggaatcagga      960

gcccctgggg aggagcagcg gcgctgggag gaggcgcggc ttggggcagc gtccctgaag     1020

tttggggccc gagatgctgc ctctcaggag cccaagtatc aactggtgct ggaggaggag     1080

gagaccattg agtttgtccg ggccactcag ctccagggtg atgaggagcc gtcagctcca     1140

cccacttcaa ctcaggccca gcagaaagag tccatccagg ccgtccgccg cagcctcccg     1200

gtgttcccat ttcgagagga gctcctggct gctattgcaa atcaccaagt cctcatcatt     1260

gaaggcgaga caggctcagg gaagaccacc cagatcccgc agtatctctt tgaggagggt     1320

tatacaaaca agggtatgaa gattgcctgc acccaacccc ggagagtggc tgccatgagt     1380

gtggccgccc gagtggcccg ggagatgggt gtgaagcttg ggaatgaggt tggctacagc     1440

atccgctttg aggactgcac atcagagcga actgtcctcc gctacatgac agatgggatg     1500

cttctccggg agttcctctc tgagcctgac ctggcgagtt acagcgtggt gatggtggat     1560

gaggcacacg aaaggaccct acacacagac attctctttg gattgatcaa ggatgttgct     1620

cgcttccgac ctgagctcaa ggtcctggtg gcttcagcca caatggacac tgcccgtttt     1680

tccaccttct ttgatgacgc ccctgtgttt cgaatccccg gacgcaggtt tcctgtggac     1740

atcttctaca ccaaggctcc agaggctgac tacttggaag cttgtgtagt atctgtgttg     1800

cagatccatg tgacccagcc ccctggggat atcctggtgt tcctgacagg acaggaggag     1860

attgaggctg cctgtgagat gctccaggat cgctgccgcc gcctgggctc caaaatccgg     1920

gagctcctgg tgctgcccat ttatgccaat ctgccctctg acatgcaggc ccgtatcttc     1980

cagcccacac cacctggggc acgaaaggtg gttgtggcaa cgaacattgc tgagacatca     2040

ctcaccattg agggcatcat ttatgtgctg gatccagggt tctgtaagca gaagagctac     2100

aacccccgca caggcatgga atcgctcact gtcacaccct gcagcaaggc ctcagccaat     2160

cagcgagctg gcagggcagg tcgggtggct gcagggaagt gcttccgcct gtataccgcc     2220

tgggcctatc agcacgagct tgaggaaacc acagtgcctg agatccagag gaccagcttg     2280

ggcaatgtcg tgttgctgct caagagctta gggatccatg acctaatgca ctttgatttc     2340

ctggaccctc caccatatga gacactgctg ctggctttgg agcagctgta tgctctggga     2400

gccctcaacc accttgggga gctcaccacg tctggtcgaa agatggcaga gctgccggtg     2460

gaccccatgc tgtccaaaat gatcttagcc tctgagaagt acagctgttc agaggagatc     2520

ctgacagtgg ctgccatgct ctctgtcaac aactccatct tctaccgacc aaaggacaag     2580

gtcgtccatg ctgacaatgc ccgtgtcaac ttctttctcc ctggcggtga ccacctggtt     2640

ctgctaaatg tttacacaca gtgggctgag agtggttact cttcccagtg gtgctatgag     2700

aactttgtac agttcagatc gatgcgccga gcccgggatg tgcgggaaca gctggaaggg     2760

ctcttggaac gtgtggaagt tggtctcagt tcctgccagg gggactatat ccgtgtacgc     2820

aaggccatca ctgctggtta cttttaccac acggcacggt tgactcggag tggctaccgc     2880

acagtgaaac agcagcagac agtcttcatt catcccaact cctccctctt tgagcaacag     2940

ccacgctggc tgctctacca cgaacttgtc ttgaccacca aagagttcat gagacaggta     3000

ctggagattg agagcagttg gcttctggag gtggctcccc attattataa ggccaaggag     3060

ctagaagatc cccatgctaa gaaaatgccc aaaaaaatag gcaaaacacg agaagagcta     3120

gggtaa                                                                3126


<210>  40
<211>  3306
<212>  DNA
<213>  Homo sapiens

<400>  40
atggagcagc ccggggcggc ggcgtcggga gcgggaggcg gcagcgagga acccggtggg       60

ggccggagca acaagcggag cgcggggaac cgggccgcca atgaagagga aacgaaaaac      120

aaacccaaat tgaacattca aataaaaact ttggcagatg atgtgcgtga ccgaattaca      180

agttttagaa aatctactgt caaaaaagaa aaacctctta ttcaacatcc tattgattct      240

caagtcgcga tgagtgagtt tcctgcagct cagccattat atgatgaacg atctttgaat      300

ttgtcagaaa aggaagtatt ggatctcttt gaaaaaatga tggaggacat gaaccttaac      360

gaagagaaaa aagctccttt acgaaacaaa gactttacca ccaaacgtga gatggttgtc      420

cagtatattt ctgccactgc caaatctggt gggctgaaaa acagcaaaca tgaatgcacc      480

ctgtcttcac aagaatatgt tcatgaatta cgatcgggta tatcagatga gaaacttctt      540

aattgcctag aatccctcag ggtttcttta accagcaatc cggtcagctg ggttaacaac      600

tttggccatg aaggtcttgg actcttattg gatgagctgg aaaagcttct ggacaaaaaa      660

cagcaagaaa atattgacaa gaagaatcag tataaactta ttcaatgcct caaagcattt      720

atgaataata agtttggatt acaaaggatt ctaggagatg aaagaagtct tttactattg      780

gcaagagcaa ttgaccccaa acaacccaac atgatgactg aaatagtaaa aatactttct      840

gctatttgca ttgttggaga agagaacatt ctagataaac ttttaggggc tataacaaca      900

gcagcagaaa gaaataacag ggaacgattt tcaccaattg tggaaggttt agaaaatcag      960

gaagccttgc aattacaggt ggcctgcatg cagtttataa atgcccttgt cacttctcct     1020

tatgagcttg attttcgaat acatttaagg aatgaattcc tccgttcagg actaaaaaca     1080

atgttaccag atctaaaaga aaaagagaat gatgagcttg atattcagtt gaaagtattt     1140

gatgaaaaca aagaagatga cctaactgaa ttatcacacc gtctcaatga cattcgagca     1200

gaaatggatg atatgaatga agtctaccat cttctatata atatgctgaa ggacactgct     1260

gctgaaaatt acttcttatc tattctacaa cattttttgc ttatcagaaa tgattattat     1320

atcaggccac aatattataa aataattgag gaatgtgttt cacagatagt gctacactgc     1380

agtggtatgg atccagactt caaatacagg caaagattag acatcgattt aactcatctg     1440

atagattctt gtgtgaacaa ggcgaaagtt gaagaaagtg aacaaaaagc tgcagagttt     1500

tcaaagaagt tcgatgaaga attcacagct cgacaggaag ctcaagcaga gcttcaaaaa     1560

agagatgaga aaatcaaaga acttgaagca gaaatccagc aacttcgaac ccaggcacaa     1620

gtactctcaa gttcatcagg aattccaggt cctcctgcag cacctccatt gccaggtgta     1680

gggccgcctc caccaccacc cgcgccacct ctacccggag gagctcctct tcctcctcca     1740

ccacctcctt tacctggaat gatggggata ccaccaccac ccccaccacc acttttattt     1800

gggggacctc ctccaccacc accccttgga ggagttcctc ctcccccagg aatatcactt     1860

aatctacctt atggaatgaa gcagaaaaaa atgtataaac ctgaagtgtc catgaagaga     1920

atcaattggt caaagattga acccacagaa ttatctgaga actgtttctg gttaagagtc     1980

aaagaagaca agtttgagaa tccagatctc tttgccaaat tggcattgaa ttttgctact     2040

cagataaaag ttcaaaagaa cgcagaagca ttagaagaaa agaagactgg gcctacaaag     2100

aagaaagtga aagaactgag aattttggat cccaaaacag ctcagaatct gtccatcttt     2160

ctgggatcat atcgcatgcc atatgaagac ataagaaacg ttattctgga ggttaatgaa     2220

gacatgctga gtgaggcttt aattcagaac cttgtgaaac atcttcctga gcagaagata     2280

ctcaacgaat tagcagagct taagaatgaa tatgatgacc tctgtgagcc tgaacaattt     2340

ggagttgtga tgagctctgt gaaaatgtta cagcctcgtc tcagtagtat cctgttcaag     2400

ctcacatttg aagaacacat aaacaacatc aaaccaagca tcatagcagt aactcttgcc     2460

tgtgaagaac tgaagaaaag tgaaagcttt aacagacttt tagagttagt tcttcttgtt     2520

ggaaactaca tgaactcagg ctcaagaaat gcccagtctt tgggatttaa gatcaacttc     2580

ctttgtaaga tcagagatac taaatcagcg gatcaaaaaa caaccctttt gcattttatt     2640

gccgacattt gtgaggaaaa atatcgagat atcctaaaat ttcctgaaga actggaacac     2700

gtagaaagtg caagcaaagt ttcagctcaa attctcaaga gcaaccttgc atcaatggaa     2760

caacaaattg ttcatctgga acgtgacatc aagaaattcc cccaagcaga aaatcaacac     2820

gataagtttg tggaaaagat gaccagcttt acaaagactg cccgagaaca gtatgaaaaa     2880

ctctccacca tgcacaacaa catgatgaag ctctatgaga atcttggaga atacttcatt     2940

tttgactcaa agacagtgag catagaagag ttctttggtg atctcaacaa cttccgaact     3000

ttgtttttgg aagcagtgag agaaaacaat aagagaagag aaatggaaga gaagaccagg     3060

agggcaaaac ttgcaaaaga gaaagctgaa caagaaaagt tagaacgcca gaagaaaaag     3120

aaacaactca ttgatataaa caaagagggt gatgagactg gtgtgatgga taatcttcta     3180

gaagccctac aatcaggtgc agcattcaga gaccgtcgaa agcggattcc aaggaatcca     3240

gataacagac gagtaccttt ggaaaggtca cgctctcgcc acaatggagc tatctcatct     3300

aagtga                                                                3306


<210>  41
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  41
atgctgtccc gatcccgctg tgtgtctcgg gcgttcagcc gctcgctctc cgccttccag       60

aaggggaact gccctctagg gagacgttcc ctgcctgggg tctccttatg ccagggacca      120

ggttacccta acagcaggaa ggttgtcatt aacaacagtg tcttcagtgt tcgctttttc      180

agaactacag ctgtatgcaa ggatgacttg gttacagtca aaaccccagc gtttgcagaa      240

tctgtcacag agggagatgt caggtgggag aaagctgttg gagacacagt tgcagaagat      300

gaagtggttt gtgagattga aactgacaag acatctgtgc aggttccatc accagcaaat      360

ggcgtgattg aagctctttt ggtacctgat gggggaaaag tcgaaggagg cactccactt      420

ttcacactca ggaaaactgg tgctgctcct gctaaggcca agccggctga agctcctgct      480

gctgcagccc caaaagcaga acctacagca gcggcagttc ctccccctgc agcacccata      540

cccactcaga tgccaccggt gccctcgccc tcacagcctc cttctggcaa acctgtgtct      600

gcagtaaaac ccactgttgc cccaccacta gctgagccag gagctggcaa aggtctgcgt      660

tcagaacatc gggagaaaat gaacaggatg cggcagcgca ttgctcagcg tctgaaggag      720

gcccagaata catgtgcaat gctgacaact tttaatgaga ttgacatgag taacatccag      780

gagatgaggg ctcggcacaa agaggctttt ttgaagaaac ataacctcaa actaggcttc      840

atgtcggcat ttgtgaaggc ctcagccttt gccttgcagg aacagcctgt tgtaaatgca      900

gtgattgacg acacaaccaa agaggtggtg tatagggatt atattgacat cagtgttgca      960

gtggccaccc cacggggtct ggtggttcca gtcatcagga atgtggaagc tatgaatttt     1020

gcagatattg aacggaccat cactgaactg ggagagaagg cccgaaagaa tgaacttgcc     1080

attgaagata tggatggcgg taccttcacc attagcaatg gaggcgtttt tggctcgctc     1140

tttggaacac ccattatcaa cccccctcag tctgccatcc tggggatgca tggcatcttt     1200

gacaggccag tggctatagg aggcaaggta gaggtgcggc ccatgatgta cgtggcactg     1260

acctatgatc accggctgat tgatggcaga gaggctgtga ctttcctccg caaaatcaag     1320

gcagcggtag aggatcccag agtcctcctc ctggatcttt ag                        1362


<210>  42
<211>  1224
<212>  DNA
<213>  Homo sapiens

<400>  42
atgtctggtg gctccgcgga ttataacaga gaacatggcg gcccagaggg aatggacccc       60

gatggtgtca tcgagagcaa ctggaatgag attgttgata actttgatga tatgaattta      120

aaggagtctc tccttcgtgg catctatgct tacggttttg agaagccttc cgctattcag      180

cagagagcta ttattccctg tattaaaggg tatgatgtga ttgctcaagc tcagtcaggt      240

actggcaaga cagccacatt tgctatttcc atcctgcaac agttggagat tgagttcaag      300

gagacccaag cactagtatt ggcccccacc agagaactgg ctcaacagat ccaaaaggta      360

attctggcac ttggagacta tatgggagcc acttgtcatg cctgcattgg tggaacaaat      420

gttcgaaatg aaatgcaaaa actgcaggct gaagcaccac atattgttgt tggtacaccc      480

gggagagtgt ttgatatgtt aaacagaaga tacctttctc caaaatggat caaaatgttt      540

gttttggatg aagcagatga aatgttgagc cgtggtttta aggatcaaat ctatgagatt      600

ttccaaaaac taaacacaag tattcaggtt gtgttgcttt ctgccacaat gccaactgat      660

gtgttggaag tgaccaaaaa attcatgaga gatccaattc gaattctggt gaaaaaggaa      720

gaattgaccc ttgaaggaat caaacagttt tatattaatg ttgagagaga ggaatggaag      780

ttggatacac tttgtgactt gtacgagaca ctgaccatta cacaggctgt tatttttctc      840

aatacgaggc gcaaggtgga ctggctgact gagaagatgc atgccagaga cttcacagtt      900

tctgctctgc atggtgacat ggaccagaag gagagagatg ttatcatgag ggaattccgg      960

tcagggtcaa gtcgtgttct gatcactact gacttgttgg ctcgcgggat tgatgtgcaa     1020

caagtgtctt tggttataaa ttatgatcta cctaccaatc gtgaaaacta tattcacaga     1080

attggcagag ggggtcgatt tgggaggaaa ggtgtggcta taaactttgt tactgaagaa     1140

gacaagagga ttcttcgtga cattgagact ttctacaata ctacagtgga ggagatgccc     1200

atgaatgtgg ctgaccttat ttaa                                            1224


<210>  43
<211>  738
<212>  DNA
<213>  Homo sapiens

<400>  43
atgaacaaca agttcgacgc tttgaaagat gatgacagtg gggaccatga tcagaatgaa       60

gaaaacagca cacagaaaga tggtgagaag gaaaaaacgg aacgagacaa gaatcagagc      120

agtagcaaga gaaaggctgt tgtccctgga ccggcagagc atcccctgca gtacaactac      180

actttttggt actccaggag aacccccggc cgtcccacga gctcacagag ctatgaacag      240

aatatcaaac agattggcac ctttgcctct gtggagcagt tctggaggtt ttatagccac      300

atggtacgtc ctggggacct gacaggccac agtgacttcc atctcttcaa agaaggaatt      360

aaacccatgt gggaggatga tgcaaataaa aatggtggca agtggattat tcggctgcgg      420

aagggcttgg cctcccgttg ctgggagaat ctcattttgg ccatgctggg ggaacagttc      480

atggttgggg aggagatctg tggggctgtg gtgtctgtcc gctttcagga agacattatt      540

tcaatatgga ataagactgc cagtgaccaa gcaaccacag cccgaatccg ggacacactt      600

cggcgagtgc ttaacctacc tcccaacacc attatggaat acaaaactca caccgacagc      660

atcaaaatgc caggcaggct gggcccccaa aggctccttt ttcaaaacct ctggaagccg      720

cggttgaatg tgccatga                                                    738


<210>  44
<211>  492
<212>  DNA
<213>  Homo sapiens

<400>  44
atgtcactcc tcttgctggt ggtctcagcc cttcacatcc tcattcttat actgcttttc       60

gtggccactt tggacaagtc ctggtggact ctccctggga aagagtccct gaatctctgg      120

tacgactgca cgtggaacaa cgacaccaaa acatgggcct gcagtaatgt cagcgagaat      180

ggctggctga aggcggtgca ggtcctcatg gtgctctccc tcattctctg ctgtctctcc      240

ttcatcctgt tcatgttcca gctctacacc atgcgacgag gaggtctctt ctatgccacc      300

ggcctctgcc agctttgcac cagcgtggcg gtgtttactg gcgccttgat ctatgccatt      360

cacgccgagg agatcctgga gaagcacccg cgagggggca gcttcggata ctgcttcgcc      420

ctggcctggg tggccttccc cctcgccctg gtcagcggca tcatctacat ccacctacgg      480

aagcgggagt ga                                                          492


<210>  45
<211>  1305
<212>  DNA
<213>  Homo sapiens

<400>  45
atgtctattc tcaagatcca tgccagggag atctttgact ctcgcgggaa tcccactgtt       60

gaggttgatc tcttcacctc aaaaggtctc ttcagagctg ctgtgcccag tggtgcttca      120

actggtatct atgaggccct agagctccgg gacaatgata agactcgcta tatggggaag      180

ggtgtctcaa aggctgttga gcacatcaat aaaactattg cgcctgccct ggttagcaag      240

aaactgaacg tcacagaaca agagaagatt gacaaactga tgatcgagat ggatggaaca      300

gaaaataaat ctaagtttgg tgcgaacgcc attctggggg tgtcccttgc cgtctgcaaa      360

gctggtgccg ttgagaaggg ggtccccctg taccgccaca tcgctgactt ggctggcaac      420

tctgaagtca tcctgccagt cccggcgttc aatgtcatca atggcggttc tcatgctggc      480

aacaagctgg ccatgcagga gttcatgatc ctcccagtcg gtgcagcaaa cttcagggaa      540

gccatgcgca ttggagcaga ggtttaccac aacctgaaga atgtcatcaa ggagaaatat      600

gggaaagatg ccaccaatgt gggggatgaa ggcgggtttg ctcccaacat cctggagaat      660

aaagaaggcc tggagctgct gaagactgct attgggaaag ctggctacac tgataaggtg      720

gtcatcggca tggacgtagc ggcctccgag ttcttcaggt ctgggaagta tgacctggac      780

ttcaagtctc ccgatgaccc cagcaggtac atctcgcctg accagctggc tgacctgtac      840

aagtccttca tcaaggacta cccagtggtg tctatcgaag atccctttga ccaggatgac      900

tggggagctt ggcagaagtt cacagccagt gcaggaatcc aggtagtggg ggatgatctc      960

acagtgacca acccaaagag gatcgccaag gccgtgaacg agaagtcctg caactgcctc     1020

ctgctcaaag tcaaccagat tggctccgtg accgagtctc ttcaggcgtg caagctggcc     1080

caggccaatg gttggggcgt catggtgtct catcgttcgg gggagactga agataccttc     1140

atcgctgacc tggttgtggg gctgtgcact gggcagatca agactggtgc cccttgccga     1200

tctgagcgct tggccaagta caaccagctc ctcagaattg aagaggagct gggcagcaag     1260

gctaagtttg ccggcaggaa cttcagaaac cccttggcca agtaa                     1305


<210>  46
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  46
atgaggctgc gggtgcggct tctgaagcgg acctggccgc tggaggtgcc cgagacggag       60

ccgacgctgg ggcatttgcg ctcgcacctg aggcagtccc tgctgtgcac ctgggggtac      120

agttctaata cccgatttac aattacattg aactacaagg atcccctcac tggagatgaa      180

gagaccttgg cttcatatgg gattgtttct ggggacttga tatgtttgat tcttcaagat      240

gacattccag cgcctaatat accttcatcc acagattcag agcattcttc actccagaat      300

aatgagcaac cctctttggc caccagctcc aatcagacta gcatgcagga tgaacaacca      360

agtgattcat tccaaggaca ggcagcccag tctggtgttt ggaatgacga cagtatgtta      420

gggcctagtc aaaattttga agctgagtca attcaagata atgcgcatat ggcagagggc      480

acaggtttct atccctcaga acccatgctc tgtagtgaat cggtggaagg gcaagtgcca      540

cattcattag agaccttgta tcaatcagct gactgttctg atgccaatga tgccttgata      600

gtgttgatac atcttctcat gttggagtca ggttacatac ctcagggcac cgaagccaaa      660

gcactgtcca tgccggagaa gtggaagttg agcggggtgt ataagctgca gtacatgcat      720

cctctctgcg agggcagctc cgctactctc acctgtgtgc ctttgggaaa cctgattgtt      780

gtaaatgcta cactaaaaat caacaatgag attagaagtg tgaaaagatt gcagctgcta      840

ccagaatctt ttatttgcaa agagaaacta ggggaaaatg tagccaacat atacaaagat      900

cttcagaaac tctctcgcct ctttaaagac cagctggtgt atcctcttct ggcttttacc      960

cgacaagcac tgaacctacc agatgtattt gggttggtcg tcctcccatt ggaactgaaa     1020

ctacggatct tccgacttct ggatgttcgt tccgtcttgt ctttgtctgc ggtttgtcgt     1080

gacctcttta ctgcttcaaa tgacccactc ctgtggaggt ttttatatct gcgtgatttt     1140

cgagacaata ctgtcagagt tcaagacaca gattggaaag aactgtacag gaagaggcac     1200

atacaaagaa aagaatcccc gaaagggcgg tttgtgatgc tcctgccatc gtcaactcac     1260

accattccat tctatcccaa ccccttgcac cctaggccat ttcctagctc ccgccttcct     1320

ccaggaatta tcgggggtga atatgaccaa agaccaacac ttccctatgt tggagaccca     1380

atcagttcac tcattcctgg tcctggggag acgcccagcc agtttcctcc actgagacca     1440

cgctttgatc cagttggccc acttccagga cctaacccca tcttgccagg gcgaggcggc     1500

cccaatgaca gatttccctt tagacccagc aggggtcggc caactgatgg ccggctgtca     1560

ttcatgtga                                                             1569


<210>  47
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  47
atgattccag cagtggtctt gctcttactc cttttggttg aacaagcagc ggccctggga       60

gagcctcagc tctgctatat cctggatgcc atcctgtttc tgtatggaat tgtcctcacc      120

ctcctctact gtcgactgaa gatccaagtg cgaaaggcag ctataaccag ctatgagaaa      180

tcagatggtg tttacacggg cctgagcacc aggaaccagg agacttacga gactctgaag      240

catgagaaac caccacagta g                                                261


<210>  48
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  48
atgaagctgg ctaactggta ctggctgagc tcagctgttc ttgccactta cggttttttg       60

gttgtggcaa acaatgaaac agaggaaatt aaagatgaaa gagcaaagga tgtctgccca      120

gtgagactag aaagcagagg gaaatgcgaa gaggcagggg agtgccccta ccaggtaagc      180

ctgcccccct tgactattca gctcccgaag caattcagca ggatcgagga ggtgttcaaa      240

gaagtccaaa acctcaagga aatcgtaaat agtctaaaga aatcttgcca agactgcaag      300

ctgcaggctg atgacaacgg agacccaggc agaaacggac tgttgttacc cagtacagga      360

gccccgggag aggttggtga taacagagtt agagaattag agagtgaggt taacaagctg      420

tcctctgagc taaagaatgc caaagaggag atcaatgtac ttcatggtcg cctggagaag      480

ctgaatcttg taaatatgaa caacatagaa aattatgttg acagcaaagt ggcaaatcta      540

acatttgttg tcaatagttt ggatggcaaa tgttcaaagt gtcccagcca agaacaaata      600

cagtcacgtc cagttcaaca tctaatatat aaagattgct ctgactacta cgcaataggc      660

aaaagaagca gtgagaccta cagagttaca cctgatccca aaaatagtag ctttgaagtt      720

tactgtgaca tggagaccat ggggggaggc tggacagtgc tgcaggcacg tctcgatggg      780

agcaccaact tcaccagaac atggcaagac tacaaagcag gctttggaaa cctcagaagg      840

gaattttggc tggggaacga taaaattcat cttctgacca agagtaagga aatgattctg      900

agaatagatc ttgaagactt taatggtgtc gaactatatg ccttgtatga tcagttttat      960

gtggctaatg agtttctcaa atatcgttta cacgttggta actataatgg cacagctgga     1020

gatgcattac gtttcaacaa acattacaac cacgatctga agtttttcac cactccagat     1080

aaagacaatg atcgatatcc ttctgggaac tgtgggctgt actacagttc aggctggtgg     1140

tttgatgcat gtctttctgc aaacttaaat ggcaaatatt atcaccaaaa atacagaggt     1200

gtccgtaatg ggattttctg gggtacctgg cctggtgtaa gtgaggcaca ccctggtggc     1260

tacaagtcct ccttcaaaga ggctaagatg atgatcagac ccaagcactt taagccataa     1320


<210>  49
<211>  1581
<212>  DNA
<213>  Homo sapiens

<400>  49
atggtgaatg aaggtcccaa ccaggaagag agcgatgaca cccctgtgcc ggagtccgca       60

ctccaagcgg accccagcgt ctcggtccat cccagcgtct cggtccatcc cagcgtctcc      120

atcaacccca gcgtctctgt ccaccccagc agttcggccc accccagtgc cttagcccaa      180

cccagtggct tggctcaccc cagtagctcg ggccctgagg acctcagcgt gatcaaggtg      240

agcaggcgcc gttgggccgt ggtcctggtg tttagctgct actccatgtg caactccttt      300

cagtggatcc agtacggctc catcaataac atcttcatgc acttctacgg tgtcagtgcc      360

tttgccattg actggctgtc catgtgctac atgctgactt acatccctct gctcctgcca      420

gtggcttggc tgctggagaa gttcggcctg cgcaccattg ctctcactgg ctcggctctc      480

aactgcctgg gggcctgggt gaagctgggc agcctgaagc cgcatctctt tccggtcacc      540

gtggtgggcc agctcatctg ctctgtggcc caggttttca tcctgggcat gccctcccgc      600

atcgcttccg tctggttcgg ggctaatgag gtttcaacag cctgctccgt ggctgtcttt      660

ggcaatcagc ttggaattgc gattgggttc ttggtccctc ctgttttggt acccaacatt      720

gaagaccggg acgagcttgc ctaccacatc agcatcatgt tctatataat aggaggtgtg      780

gccactctcc tcctcatcct tgtcatcatt gtgttcaagg agaaacctaa atatcccccc      840

agcagggccc aatccctgag ctatgccttg acctctcctg atgcctcata cttaggttcc      900

atcgcccggc tcttcaaaaa tctcaacttt gtgctgcttg tcatcaccta tggtctgaat      960

gctggtgctt tttatgcctt gtccactctt ctgaatcgca tggtgatctg gcactacccg     1020

ggggaagaag tgaatgctgg aagaattggc ctgacgatcg tcattgcagg aatgcttggg     1080

gctgtgatct caggaatctg gctggatagg tccaaaacct acaaagagac aaccctggta     1140

gtctatatca tgacactggt gggcatggtg gtgtacacgt ttaccttgaa cctgggacac     1200

ctgtgggtag tgttcatcac tgctggcaca atgggcttct ttatgactgg ctatctccca     1260

ctgggatttg agtttgctgt ggagctcacg tacccagaat cagaaggcat ctcctccggc     1320

ctcctcaaca tatctgcaca ggtatttggg atcatcttta ccatctccca gggccagatt     1380

attgacaact atggaaccaa gcctgggaac atcttcctgt gtgtgttcct tactcttgga     1440

gcagccctca ctgcattcat taaggcagat ctccggagac agaaagcaaa caaagaaact     1500

cttgagaaca aactccaaga ggaggaggag gagagcaaca ccagcaaagt gcccactgct     1560

gtgtcagagg atcatctctg a                                               1581


<210>  50
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  50
atgagctccc agattcgtca gaattattcc accgacgtgg aggcagccgt caacagcctg       60

gtcaatttgt acctgcaggc ctcctacacc tacctctctc tgggcttcta tttcgaccgc      120

gatgatgtgg ctctggaagg cgtgagccac ttcttccgcg aattggccga ggagaagcgc      180

gagggctacg agcgtctcct gaagatgcaa aaccagcgtg gcggccgcgc tctcttccag      240

gacatcaaga agccagctga agatgagtgg ggtaaaaccc cagacgccat gaaagctgcc      300

atggccctgg agaaaaagct gaaccaggcc cttttggatc ttcatgccct gggttctgcc      360

cgcacggacc cccatctctg tgacttcctg gagactcact tcctagatga ggaagtgaag      420

cttatcaaga agatgggtga ccacctgacc aacctccaca ggctgggtgg cccggaggct      480

gggctgggcg agtatctctt cgaaaggctc actctcaagc acgactaa                   528


<210>  51
<211>  2385
<212>  DNA
<213>  Homo sapiens

<400>  51
atggagctga ggccctggtt gctatgggtg gtagcagcaa caggaacctt ggtcctgcta       60

gcagctgatg ctcagggcca gaaggtcttc accaacacgt gggctgtgcg catccctgga      120

ggcccagcgg tggccaacag tgtggcacgg aagcatgggt tcctcaacct gggccagatc      180

ttcggggact attaccactt ctggcatcga ggagtgacga agcggtccct gtcgcctcac      240

cgcccgcggc acagccggct gcagagggag cctcaagtac agtggctgga acagcaggtg      300

gcaaagcgac ggactaaacg ggacgtgtac caggagccca cagaccccaa gtttcctcag      360

cagtggtacc tgtctggtgt cactcagcgg gacctgaatg tgaaggcggc ctgggcgcag      420

ggctacacag ggcacggcat tgtggtctcc attctggacg atggcatcga gaagaaccac      480

ccggacttgg caggcaatta tgatcctggg gccagttttg atgtcaatga ccaggaccct      540

gacccccagc ctcggtacac acagatgaat gacaacaggc acggcacacg gtgtgcgggg      600

gaagtggctg cggtggccaa caacggtgtc tgtggtgtag gtgtggccta caacgcccgc      660

attggagggg tgcgcatgct ggatggcgag gtgacagatg cagtggaggc acgctcgctg      720

ggcctgaacc ccaaccacat ccacatctac agtgccagct ggggccccga ggatgacggc      780

aagacagtgg atgggccagc ccgcctcgcc gaggaggcct tcttccgtgg ggttagccag      840

ggccgagggg ggctgggctc catctttgtc tgggcctcgg ggaacggggg ccgggaacat      900

gacagctgca actgcgacgg ctacaccaac agtatctaca cgctgtccat cagcagcgcc      960

acgcagtttg gcaacgtgcc gtggtacagc gaggcctgct cgtccacact ggccacgacc     1020

tacagcagtg gcaaccagaa tgagaagcag atcgtgacga ctgacttgcg gcagaagtgc     1080

acggagtctc acacgggcac ctcagcctct gcccccttag cagccggcat cattgctctc     1140

accctggagg ccaataagaa cctcacatgg cgggacatgc aacacctggt ggtacagacc     1200

tcgaagccag cccacctcaa tgccaacgac tgggccacca atggtgtggg ccggaaagtg     1260

agccactcat atggctacgg gcttttggac gcaggcgcca tggtggccct ggcccagaat     1320

tggaccacag tggcccccca gcggaagtgc atcatcgaca tcctcaccga gcccaaagac     1380

atcgggaaac ggctcgaggt gcggaagacc gtgaccgcgt gcctgggcga gcccaaccac     1440

atcactcggc tggagcacgc tcaggcgcgg ctcaccctgt cctataatcg ccgtggcgac     1500

ctggccatcc acctggtcag ccccatgggc acccgctcca ccctgctggc agccaggcca     1560

catgactact ccgcagatgg gtttaatgac tgggccttca tgacaactca ttcctgggat     1620

gaggatccct ctggcgagtg ggtcctagag attgaaaaca ccagcgaagc caacaactat     1680

gggacgctga ccaagttcac cctcgtactc tatggcaccg cccctgaggg gctgcccgta     1740

cctccagaaa gcagtggctg caagaccctc acgtccagtc aggcctgtgt ggtgtgcgag     1800

gaaggcttct ccctgcacca gaagagctgt gtccagcact gccctccagg gttcgccccc     1860

caagtcctcg atacgcacta tagcaccgag aatgacgtgg agaccatccg ggccagcgtc     1920

tgcgccccct gccacgcctc atgtgccaca tgccaggggc cggccctgac agactgcctc     1980

agctgcccca gccacgcctc cttggaccct gtggagcaga cttgctcccg gcaaagccag     2040

agcagccgag agtccccgcc acagcagcag ccacctcggc tgcccccgga ggtggaggcg     2100

gggcaacggc tgcgggcagg gctgctgccc tcacacctgc ctgaggtggt ggccggcctc     2160

agctgcgcct tcatcgtgct ggtcttcgtc actgtcttcc tggtcctgca gctgcgctct     2220

ggctttagtt ttcggggggt gaaggtgtac accatggacc gtggcctcat ctcctacaag     2280

gggctgcccc ctgaagcctg gcaggaggag tgcccgtctg actcagaaga ggacgagggc     2340

cggggcgaga ggaccgcctt tatcaaagac cagagcgccc tctga                     2385


<210>  52
<211>  1239
<212>  DNA
<213>  Homo sapiens

<400>  52
atgacggatc tatactacct cagtcagaca gatggagcag gtgattggcg ggaaaaagag       60

gccaaagatc tgacagaact ggttcagcgg agaataacat atcttcagaa tcccaaggac      120

tgcagcaaag ccaaaaagct ggtgtgtaat atcaacaaag gctgtggcta tggctgtcag      180

ctccatcatg tggtctactg cttcatgatt gcatatggca cccagcgaac actcatcttg      240

gaatctcaga attggcgcta tgctactggt ggatgggaga ctgtatttag gcctgtaagt      300

gagacatgca cagacagatc tggcatctcc actggacact ggtcaggtga agtgaaggac      360

aaaaatgttc aagtggtcga gcttcccatt gtagacagtc ttcatccccg tcctccatat      420

ttacccttgg ctgtaccaga agacctcgca gatcgacttg tacgagtgca tggtgaccct      480

gcagtgtggt gggtgtctca gtttgtcaaa tacttgatcc gcccacagcc ttggctagaa      540

aaagaaatag aagaagccac caagaagctt ggcttcaaac atccagttat tggagtccat      600

gtcagacgca cagacaaagt gggaacagaa gctgccttcc atcccattga agagtacatg      660

gtgcatgttg aagaacattt tcagcttctt gcacgcagaa tgcaagtgga caaaaaaaga      720

gtgtatttgg ccacagatga cccttcttta ttaaaggagg caaaaacaaa gtaccccaat      780

tatgaattta ttagtgataa ctctatttcc tggtcagctg gactgcacaa tcgatacaca      840

gaaaattcac ttcgtggagt gatcctggat atacattttc tctctcaggc agacttccta      900

gtgtgtactt tttcatccca ggtctgtcga gttgcttatg aaattatgca aacactacat      960

cctgatgcct ctgcaaactt ccattcttta gatgacatct actattttgg gggccagaat     1020

gcccacaatc aaattgccat ttatgctcac caaccccgaa ctgcagatga aattcccatg     1080

gaacctggag atatcattgg tgtggctgga aatcattggg atggctattc taaaggtgtc     1140

aacaggaaat tgggaaggac gggcctatat ccctcctaca aagttcgaga gaagatagaa     1200

acggtcaagt accccacata tcctgaggct gagaaataa                            1239


<210>  53
<211>  1866
<212>  DNA
<213>  Homo sapiens

<400>  53
atggcggagc tgacggtgga ggttcgcggc tctaacgggg ctttctacaa gggatttatc       60

aaagatgttc atgaagactc ccttacagtt gtttttgaaa ataattggca accagaacgc      120

caggttccat ttaatgaagt tagattacca ccaccacctg atataaaaaa agaaattagt      180

gaaggagatg aagtagaggt atattcaaga gcaaatgacc aagagccatg tgggtggtgg      240

ttggctaaag ttcggatgat gaaaggagaa ttttatgtca ttgaatatgc tgcttgtgac      300

gctacttaca atgaaatagt cacatttgaa cgacttcggc ctgtcaatca aaataaaact      360

gtcaaaaaaa ataccttctt taaatgcaca gtggatgttc ctgaggattt gagagaggcg      420

tgtgctaatg aaaatgcaca taaagatttt aagaaagcag taggagcatg cagaattttt      480

taccatccag aaacaacaca gctaatgata ctgtctgcca gtgaagcaac tgtgaagaga      540

gtaaacatct taagtgacat gcatttgcga agtattcgta cgaagttgat gcttatgtcc      600

agaaatgaag aggccactaa gcatttagaa tgcacaaaac aacttgcagc agcttttcat      660

gaggaatttg ttgtgagaga agatttaatg ggcctggcaa taggaacaca tggtagtaac      720

atccagcaag ctaggaaggt tcctggagtt accgccattg agctagatga agatactgga      780

acattcagaa tctacggaga gagtgctgat gctgtaaaaa aggctagagg tttcttggaa      840

tttgtggagg attttattca ggttcctagg aatctcgttg gaaaagtaat tggaaaaaat      900

ggcaaagtta ttcaagaaat agtggacaaa tctggtgtgg ttcgagtgag aattgaaggg      960

gacaatgaaa ataaattacc cagagaagac ggtatggttc catttgtatt tgttggcact     1020

aaagaaagca ttggaaatgt gcaggttctt ctagagtatc atattgccta tctaaaggaa     1080

gtagaacagc taagaatgga acgcctacag attgatgaac agctgcgaca gattggttct     1140

aggtcttata gcggaagagg cagaggtcgt cggggaccta attacacctc cggttatggt     1200

acaaattctg agctgtctaa cccctctgaa acggaatctg agcgtaaaga cgagctgagt     1260

gattggtcat tggcaggaga agatgatcga gacagccgac atcagcgtga cagcaggaga     1320

cgcccaggag gaagaggcag aagtgtttca gggggtcgag gtcgtggtgg accacgtggt     1380

ggcaaatcct ccatcagttc tgtgctcaaa gatccagaca gcaatccata cagcttactt     1440

gataatacag aatcagatca gactgcagac actgatgcca gcgaatctca tcacagtact     1500

aaccgtcgta ggcggtctcg tagacgaagg actgatgaag atgctgttct gatggatgga     1560

atgactgaat ctgatacagc ttcagttaat gaaaatgggc tagtcacagt tgcagattat     1620

atttctagag ctgagtctca gagcagacaa agaaacctcc caagggaaac tttggctaaa     1680

aacaagaaag aaatggcaaa agatgtgatt gaagagcatg gtccttcaga aaaggcaata     1740

aacggcccaa ctagtgcttc tggcgatgac atttctaagc tacagcgtac tccaggagaa     1800

gaaaagatta ataccttaaa agaagaaaac actcaagaag cagcagtcct gaatggtgtt     1860

tcataa                                                                1866


<210>  54
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  54
atggggaagg tgaaggtcgg agtcaacgga tttggtcgta ttgggcgcct ggtcaccagg       60

gctgctttta actctggtaa agtggatatt gttgccatca atgacccctt cattgacctc      120

aactacatgg tttacatgtt ccaatatgat tccacccatg gcaaattcca tggcaccgtc      180

aaggctgaga acgggaagct tgtcatcaat ggaaatccca tcaccatctt ccaggagcga      240

gatccctcca aaatcaagtg gggcgatgct ggcgctgagt acgtcgtgga gtccactggc      300

gtcttcacca ccatggagaa ggctggggct catttgcagg ggggagccaa aagggtcatc      360

atctctgccc cctctgctga tgcccccatg ttcgtcatgg gtgtgaacca tgagaagtat      420

gacaacagcc tcaagatcat cagcaatgcc tcctgcacca ccaactgctt agcacccctg      480

gccaaggtca tccatgacaa ctttggtatc gtggaaggac tcatgaccac agtccatgcc      540

atcactgcca cccagaagac tgtggatggc ccctccggga aactgtggcg tgatggccgc      600

ggggctctcc agaacatcat ccctgcctct actggcgctg ccaaggctgt gggcaaggtc      660

atccctgagc tgaacgggaa gctcactggc atggccttcc gtgtccccac tgccaacgtg      720

tcagtggtgg acctgacctg ccgtctagaa aaacctgcca aatatgatga catcaagaag      780

gtggtgaagc aggcgtcgga gggccccctc aagggcatcc tgggctacac tgagcaccag      840

gtggtctcct ctgacttcaa cagcgacacc cactcctcca cctttgacgc tggggctggc      900

attgccctca acgaccactt tgtcaagctc atttcctggt atgacaacga atttggctac      960

agcaacaggg tggtggacct catggcccac atggcctcca aggagtaa                  1008


<210>  55
<211>  1011
<212>  DNA
<213>  Homo sapiens

<400>  55
atgtccaata tggagaacag ctttgacgat gtttcttgcc tctctcccca gaacctggga       60

tcctcatcgc caagcaaaaa gcagagcaag gaaaacacca tcacaataaa ctgtgtgacg      120

ttccctcacc cagacacgat gccggaacag cagctgctga aaccaaccga gtggagctac      180

tgcgactact tctgggctga taagaaggac ccccaaggca acggcaccgt ggctgggttt      240

gaactactgc tccagaaaca gctgaagggc aaacaaatgc agaaggaaat gtcagaattc      300

atccgggaaa ggataaagat tgaagaagac tatgcgaaga acttagctaa gctctctcag      360

aactccttgg cttcacagga ggaaggctcc ttgggagagg cgtgggccca ggtgaagaag      420

agcctggcgg acgaagcaga agttcacctc aagttctctg ccaagcttca cagcgaggtg      480

gagaagcccc tgatgaactt ccgtgagaac ttcaagaaag acatgaagaa gtgcgaccac      540

cacattgccg accttcgcaa gcagctcgcc agccgctatg cctcggtgga gaaggcccgg      600

aaagccctca cagagcggca gagagacctg gagatgaaga cccagcagct ggagatcaag      660

ctgagcaaca agacagagga ggacatcaag aaggcgcgga gaaagtccac acaggctgga      720

gacgacctca tgcgctgtgt ggatctctac aaccaggccc agtccaaatg gtttgaagag      780

atggtgacca ccacattgga gctagagcgg ctggaggtgg agagggtaga gatgatccgg      840

cagcacctgt gccagtacac gcagctgcgg catgaaacag acatgttcaa ccaaagcaca      900

gtcgagcccg tggatcagct gcttcgaaaa gtggacccgg ccaaagacag ggagctgtgg      960

gtcagagagc acaagacggg caacatccgc cctgtggaca tggagatcta g              1011


<210>  56
<211>  1776
<212>  DNA
<213>  Homo sapiens

<400>  56
atggctccag agatcaactt gccgggccca atgagcctca ttgataacac taaagggcag       60

ctggtggtga atccagaagc tctgaagatc ctatctgcaa ttacgcagcc tgtggtggtg      120

gtggcgattg tgggcctcta tcgcacaggc aaatcctacc tgatgaacaa gctggctggg      180

aagaaaaacg gcttctctct aggctccaca gtgaagtctc acaccaaggg aatctggatg      240

tggtgtgtgc ctcatcccaa gaagccagaa cacaccctag ttctgctcga cactgagggc      300

ctgggagata tagagaaggg tgacaatgag aatgactcct ggatctttgc cttggccatc      360

ctcctgagca gcaccttcgt gtacaatagc atgggaacca tcaaccagca ggccatggac      420

caacttcact atgtgacaga gctgacagat cgaatcaagg caaactcctc acctggtaac      480

aattctgtag acgactcagc tgactttgtg agcttttttc cagcatttgt gtggactctc      540

agagatttca ccctggaact ggaagtagat ggagaaccca tcactgctga tgactacttg      600

gagctttcgc taaagctaag aaaaggtact gataagaaaa gtaaaagctt taatgatcct      660

cggttgtgca tccgaaagtt cttccccaag aggaagtgct tcgtcttcga ttggcccgct      720

cctaagaagt accttgctca cctagagcag ctaaaggagg aagagctgaa ccctgatttc      780

atagaacaag ttgcagaatt ttgttcctac atcctcagcc attccaatgt caagactctt      840

tcaggtggca ttccagtcaa tgggcctcgt ctagagagcc tggtgctgac ctacgtcaat      900

gccatcagca gtggggatct accctgcatg gagaacgcag tcctggcctt ggcccagata      960

gagaactcag ccgcagtgga aaaggctatt gcccactatg aacagcagat gggccagaag     1020

gtgcagctgc ccacggaaac cctccaggag ctgctggacc tgcacaggga cagtgagaga     1080

gaggccattg aagtcttcat gaagaactct ttcaaggatg tggaccaaat gttccagagg     1140

aaattagggg cccagttgga agcaaggcga gatgactttt gtaagcagaa ttccaaagca     1200

tcatcagatt gttgcatggc tttacttcag gatatatttg gccctttaga agaagatgtc     1260

aagcagggaa cattttctaa accaggaggt taccgtctct ttactcagaa gctgcaggag     1320

ctgaagaata agtactacca ggtgccaagg aaggggatac aggccaaaga ggtgctgaaa     1380

aaatatttgg agtccaagga ggatgtggct gatgcacttc tacagactga tcagtcactc     1440

tcagaaaagg aaaaagcgat tgaagtggaa cgtataaagg ctgaatctgc agaagctgca     1500

aagaaaatgt tggaggaaat acaaaagaag aatgaggaga tgatggaaca gaaagagaag     1560

agttatcagg aacatgtgaa acaattgact gagaagatgg agagggacag ggcccagtta     1620

atggcagagc aagagaagac cctcgctctt aaacttcagg aacaggaacg ccttctcaag     1680

gagggattcg agaatgagag caagagactt caaaaagaca tatgggatat ccagatgaga     1740

agcaaatcat tggagccaat atgtaacata ctctaa                               1776


<210>  57
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  57
atggcagccc aatacggcag tatgagcttc aaccccagca caccaggggc cagttatggg       60

cctggaaggc aagagcccag aaattcccaa ttgagaattg tgttagtggg taaaaccgga      120

gcaggaaaaa gtgcaacagg aaacagcatc cttggccgga aagtgtttca ttctggcact      180

gcagcaaaat ccattaccaa gaagtgtgag aaacgcagca gctcatggaa ggaaacagaa      240

cttgtcgtag ttgacacacc aggcattttc gacacagagg tgcccaatgc tgaaacgtcc      300

aaggagatta ttcgctgcat tcttctgacc tccccagggc ctcatgctct gcttctggtg      360

gttccactgg gccgttacac tgaggaagag cacaaagcca cagagaagat cctgaaaatg      420

tttggagaga gggctagaag tttcatgatt ctcatattca cccggaaaga tgacttaggt      480

gacaccaatt tgcatgacta cttaagggaa gctccagaag acattcaaga cttgatggac      540

attttcggtg accgctactg tgcgttaaac aacaaggcaa caggcgctga gcaggaggcc      600

cagagggcac agttgctggg cctgatccag cgcgtggtga gggagaacaa ggaaggctgc      660

tacactaata ggatgtacca aagggcggag gaggagatcc agaagcaaac acaagcaatg      720

caagaactcc acagagtgga gctggagaga gagaaagcgc ggataagaga ggagtatgaa      780

gagaaaatca gaaagctgga agataaagtg gagcaggaaa agagaaagaa gcaaatggag      840

aagaaactag cagaacagga ggctcactat gctgtaaggc agcaaagggc aagaacggaa      900

gtggagagta aggatgggat acttgaatta atcatgacag cgttacagat tgcttccttt      960

attttgttac gtctgttcgc ggaagattaa                                       990


<210>  58
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  58
atggctgctc gcagagctct gcacttcgta ttcaaagtgg gaaaccgctt ccagacggcg       60

cgtttctatc gggacgtcct ggggatgaag gttctgcggc atgaggaatt tgaagaaggc      120

tgcaaagctg cctgtaatgg gccttatgat gggaaatgga gtaaaacaat ggtgggattt      180

gggcctgagg atgatcattt tgtcgcagaa ctgacttaca attatggcgt cggagactac      240

aagcttggca atgactttat gggaatcacg ctcgcttcta gccaggctgt cagcaacgcc      300

aggaagctgg agtggccact gacggaagtt gcagaaggtg tttttgaaac cgaggccccg      360

ggaggatata agttctattt gcagaatcgc agtctgcctc agtcagatcc tgtattaaaa      420

gtaactctag cagtgtctga tcttcaaaag tccttgaact actggtgtaa tctactggga      480

atgaaaattt atgaaaaaga tgaagaaaag caaagggctt tgctgggcta tgctgataac      540

cagtgtaagc tggagctaca gggcgtcaag ggtggggtgg accatgcagc agcttttgga      600

agaattgcct tctcttgccc ccagaaagag ttgccagact tagaagactt gatgaaaagg      660

gagaaccaga agattctgac tcccctggtg agcctggaca ccccagggaa agcaacagta      720

caggtggtca ttctggccga ccctgacgga catgaaattt gctttgtcgg ggatgaagca      780

tttcgagaac tttctaagat ggatccagag ggaagcaaat tgttggatga tgcaatggca      840

gcagataaaa gtgacgagtg gtttgccaaa cacaataaac ccaaagcttc aggttaa         897


<210>  59
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  59
atgcggctcc tgcctctagc cccaggtcgg ctccggcggg gcagcccccg ccacctgccc       60

tcctgcagcc cagcgctgct actgctggtg ctgggcggct gcctgggggt cttcggggtg      120

gctgcgggaa cccggaggcc caacgtggtg ctgctcctca cggacgacca ggacgaagtg      180

ctcggcggca tgacaccgct aaagaaaacc aaagctctca tcggagagat ggggatgact      240

ttttccagtg cttatgtgcc aagtgctctc tgctgcccca gcagagccag tatcctgaca      300

ggaaagtacc cacataatca tcacgttgtg aacaacactc tggaggggaa ctgcagtagt      360

aagtcctggc agaagatcca agaaccaaat actttcccag caattctcag atcaatgtgt      420

ggttatcaga ccttttttgc agggaaatat ttaaatgagt acggagcccc agatgcaggt      480

ggactagaac acgttcctct gggttggagt tactggtatg ccttggaaaa gaattctaag      540

tattataatt acaccctgtc tatcaatggg aaggcacgga agcatggtga aaactatagt      600

gtggactacc tgacagatgt tttggctaat gtctccttgg actttctgga ctacaagtcc      660

aactttgagc ccttcttcat gatgatcgcc actccagcgc ctcattcgcc ttggacagct      720

gcacctcagt accagaaggc tttccagaat gtctttgcac caagaaacaa gaacttcaac      780

atccatggaa cgaacaagca ctggttaatt aggcaagcca agactccaat gactaattct      840

tcaatacagt ttttagataa tgcatttagg aaaaggtggc aaactctcct ctcagttgat      900

gaccttgtgg agaaactggt caagaggctg gagttcactg gggagctcaa caacacttac      960

atcttctata cctcagacaa tggctatcac acaggacagt tttccttgcc aatagacaag     1020

agacagctgt atgagtttga tatcaaagtt ccactgttgg ttcgaggacc tgggatcaaa     1080

ccaaatcaga caagcaagat gctggttgcc aacattgact tgggtcctac tattttggac     1140

attgctggct acgacctaaa taagacacag atggatggga tgtccttatt gcccattttg     1200

agaggtgcca gtaacttgac ctggcgatca gatgtcctgg tggaatacca aggagaaggc     1260

cgtaacgtca ctgacccaac atgcccttcc ctgagtcctg gcgtatctca atgcttccca     1320

gactgtgtat gtgaagatgc ttataacaat acctatgcct gtgtgaggac aatgtcagca     1380

ttgtggaatt tgcagtattg cgagtttgat gaccaggagg tgtttgtaga agtctataat     1440

ctgactgcag acccagacca gatcactaac attgctaaaa ccatagaccc agagctttta     1500

ggaaagatga actatcggtt aatgatgtta cagtcctgtt ctgggccaac ctgtcgcact     1560

ccaggggttt ttgaccccgg atacaggttt gacccccgtc tcatgttcag caatcgcggc     1620

agtgtcagga ctcgaagatt ttccaaacat cttctgtag                            1659


<210>  60
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  60
atggaagctg ttgccaagtt tgatttcact gcttcaggtg aggatgaact gagctttcac       60

actggagatg ttttgaagat tttaagtaac caagaggagt ggtttaaggc ggagcttggg      120

agccaggaag gatatgtgcc caagaatttc atagacatcc agtttcccaa atggtttcac      180

gaaggcctct ctcgacacca ggcagagaac ttactcatgg gcaaggaggt tggcttcttc      240

atcatccggg ccagccagag ctccccaggg gacttctcca tctctgtcag gcatgaggat      300

gacgttcaac acttcaaggt catgcgagac aacaagggta attactttct gtggactgag      360

aagtttccat ccctaaataa gctggtagac tactacagga caaattccat ctccagacag      420

aagcagatct tccttagaga cagaacccga gaagaccagg gtcaccgggg caacagcctg      480

gaccggaggt cccagggagg cccacacctc agtggggctg tgggagaaga aatccgacct      540

tcgatgaacc ggaagctgtc ggatcacccc ccgacccttc ccctgcagca gcaccagcac      600

cagccacagc ctccgcaata tgccccagcg ccccagcagc tgcagcagcc cccacagcag      660

cgatatctgc agcaccacca tttccaccag gaacgccgag gaggcagcct tgacataaat      720

gatgggcatt gtggcaccgg cttgggcagt gaaatgaatg cggccctcat gcatcggaga      780

cacacagacc cagtgcagct ccaggcggca gggcgagtgc ggtgggcccg ggcgctgtat      840

gactttgagg ccctggagga tgacgagctg gggttccaca gcggggaggt ggtggaggtc      900

ctggatagct ccaacccatc ctggtggacc ggccgcctgc acaacaagct gggcctcttc      960

cctgccaact acgtggcacc catgacccga taa                                   993


<210>  61
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  61
atgtccgggg agtcagccag gagcttgggg aagggaagcg cgcccccggg gccggtcccg       60

gagggctcga tccgcatcta cagcatgagg ttctgcccgt ttgctgagag gacgcgtcta      120

gtcctgaagg ccaagggaat caggcatgaa gtcatcaata tcaacctgaa aaataagcct      180

gagtggttct ttaagaaaaa tccctttggt ctggtgccag ttctggaaaa cagtcagggt      240

cagctgatct acgagtctgc catcacctgt gagtacctgg atgaagcata cccagggaag      300

aagctgttgc cggatgaccc ctatgagaaa gcttgccaga agatgatctt agagttgttt      360

tctaaggtgc catccttggt aggaagcttt attagaagcc aaaataaaga agactatgct      420

ggcctaaaag aagaatttcg taaagaattt accaagctag aggaggttct gactaataag      480

aagacgacct tctttggtgg caattctatc tctatgattg attacctcat ctggccctgg      540

tttgaacggc tggaagcaat gaagttaaat gagtgtgtag accacactcc aaaactgaaa      600

ctgtggatgg cagccatgaa ggaagatccc acagtctcag ccctgcttac tagtgagaaa      660

gactggcaag gtttcctaga gctctactta cagaacagcc ctgaggcctg tgactatggg      720

ctctga                                                                 726


<210>  62
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  62
atgttgggca tgatcaagaa ctcgctgttc ggaagcgtag agacgtggcc ttggcaggtc       60

ctaagcaaag gggacaagga agaagttgcc tatgaagaaa gggcctgtga aggcggcaaa      120

tttgccacag tagaagtgac agataagcct gtggatgagg ctctacggga agcaatgccc      180

aaggtcgcaa agtatgcggg gggcaccaat gacaagggaa ttgggatggg gatgacagtc      240

cctatttcct ttgctgtgtt ccccaatgaa gatggctctc tgcagaagaa attaaaagtc      300

tggttccgga ttccaaacca atttcaaagc gacccaccag ctcccagtga caaaagcgtt      360

aagattgagg aacgggaagg catcactgtc tattccatgc agtttggtgg ttatgccaag      420

gaagcagact acgtagcaca agccacccgt ctgcgtgctg ccctggaggg cacagccacc      480

taccgggggg acatctactt ctgcacgggt tatgaccctc ccatgaagcc ctacggacgg      540

cgcaatgaga tctggctgtt gaagacatga                                       570


<210>  63
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  63
atgcctgaac cagtcaaatc tgctccagtc cctaaaaaag gctccaagaa ggccattaac       60

aaggctcaga agaaggatgg aaagaagcgc aaacgcagcc gcaaggagag ctactctgtg      120

tatgtgtaca aggtgctgaa gcaggtccac cccgacaccg gcatctcttc caaggctatg      180

ggaatcatga actccttcgt caacgacatc tttgagcgta tcgccggaga agcgtcacgc      240

ctggcgcatt acaacaagcg ctcgaccatc acttcgaggg agatccagac ggccgtgcgc      300

ctactgctac ccggggaatt ggccaagcac gccgtgtccg agggcaccaa ggccgtcacc      360

aagtatacca gctccaagtg a                                                381


<210>  64
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  64
atggctcgta cgaagcaaac agctcgcaag tctaccggcg gcaaagctcc gcgcaagcag       60

cttgctacta aagcagcccg taagagcgct ccggccaccg gtggcgtgaa gaaacctcat      120

cgctaccgcc cgggcaccgt ggccttgcgc gaaatccgtc gctaccagaa gtccaccgag      180

ctgctgatcc ggaagctgcc gttccagcgc ctggtgcgag aaatcgccca ggacttcaaa      240

accgacctgc gtttccagag ctctgcggtg atggcgctgc aggaggcttg tgaggcctac      300

ctggtgggac tcttcgaaga caccaatctg tgcgctattc acgctaaacg cgtcaccatc      360

atgcccaaag atatccagct ggcacgtcgc atccgtgggg aaagggcata a               411


<210>  65
<211>  312
<212>  DNA
<213>  Homo sapiens

<400>  65
atgtctgggc gcggcaaagg cgggaagggt ctgggcaaag gaggcgctaa gcgccaccgc       60

aaagttctgc gcgacaacat tcagggcatc accaagcccg ccatccgacg cctggcacgg      120

cgtggaggcg ttaagcgcat ctcaggcctt atatacgagg agacacgcgg agttcttaaa      180

gtgtttttgg agaatgtaat ccgcgatgca gttacctaca cggagcacgc caaacgcaag      240

acagtcacag ccatggacgt ggtttacgcg ctcaagcgcc agggccgcac cctgtatggc      300

tttggcggct ga                                                          312


<210>  66
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  66
atgcgccctg aagacagaat gttccatatc agagctgtga tcttgagagc cctctccttg       60

gctttcctgc tgagtctccg aggagctggg gccatcaagg cggaccatgt gtcaacttat      120

gccgcgtttg tacagacgca tagaccaaca ggggagttta tgtttgaatt tgatgaagat      180

gagatgttct atgtggatct ggacaagaag gagaccgtct ggcatctgga ggagtttggc      240

caagcctttt cctttgaggc tcagggcggg ctggctaaca ttgctatatt gaacaacaac      300

ttgaatacct tgatccagcg ttccaaccac actcaggcca ccaacgatcc ccctgaggtg      360

accgtgtttc ccaaggagcc tgtggagctg ggccagccca acaccctcat ctgccacatt      420

gacaagttct tcccaccagt gctcaacgtc acgtggctgt gcaacgggga gctggtcact      480

gagggtgtcg ctgagagcct cttcctgccc agaacagatt acagcttcca caagttccat      540

tacctgacct ttgtgccctc agcagaggac ttctatgact gcagggtgga gcactggggc      600

ttggaccagc cgctcctcaa gcactgggag gcccaagagc caatccagat gcctgagaca      660

acggagactg tgctctgtgc cctgggcctg gtgctgggcc tagtcggcat catcgtgggc      720

accgtcctca tcataaagtc tctgcgttct ggccatgacc cccgggccca ggggaccctg      780

tga                                                                    783


<210>  67
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  67
atgtcccacg gccccaagca gcccggcgcg gccgccgcgc cggcgggcgg caaggctccg       60

ggccagcatg ggggcttcgt ggtgactgtc aagcaagagc gcggcgaggg tccacgcgcg      120

ggcgagaagg ggtcccacga ggaggagccg gtgaagaaac gcggctggcc caagggcaag      180

aagcggaaga agattctgcc gaatgggccc aaggcaccgg tcacgggcta cgtgcgcttc      240

ctgaacgagc ggcgcgagca gatccgcacg cgccacccgg atctgccctt tcccgagatc      300

accaagatgc tgggcgccga gtggagcaag ctgcagccaa cggaaaagca gcggtacctg      360

gatgaggccg agagagagaa gcagcagtac atgaaggagc tgcgggcgta ccagcagtct      420

gaagcctata agatgtgcac ggagaagatc caggagaaga agatcaagaa agaagactcg      480

agctctgggc tcatgaacac tctcctgaat ggacacaagg gtggggactg cgatggcttc      540

tccaccttcg atgttcccat cttcactgaa gagttcttgg accaaaacaa agcgcgtgag      600

gcggagcttc ggcgcttgcg gaagatgaat gtggccttcg aggagcagaa cgcggtactg      660

cagaggcaca cgcagagcat gagcagcgcg cgcgagcgtc tggagcagga gctggcgctg      720

gaggagcgga ggacgctggc gctgcagcag cagctccagg ccgtgcgcca ggcgctcacc      780

gccagcttcg cctcactgcc ggtgccgggc acgggcgaaa cgcccacgct gggcactctg      840

gacttctaca tggcccggct tcacggagcc atcgagcgcg accccgccca gcacgagaag      900

ctcatcgtcc gcatcaagga aatcctggcc caggtcgcca gcgagcacct gtga            954


<210>  68
<211>  273
<212>  DNA
<213>  Homo sapiens

<400>  68
atgcccaaga gaaaggcaaa aggagatgct aaaggtgata aagcaaaggt gaaggatgag       60

ccacagagga gatcagctcg gttgtctgct aaaccagctc ctccaaaacc agagcccagg      120

cctaaaaagg cctctgcaaa gaagggagag aagcttccca aagggagaaa ggggaaagca      180

gatgctggaa aggatgggaa caaccctgca aaaaaccgag atgcctctac actccagtcc      240

cagaaagcgg aaggcactgg ggatgccaag tga                                   273


<210>  69
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  69
atgagttcct atttcgtgaa ctccaccttc cccgtcactc tggccagcgg gcaggagtcc       60

ttcctgggcc agctaccgct ctattcgtcg ggctatgcgg acccgctgag acattacccc      120

gcgccctacg ggccagggcc gggccaggac aagggctttg ccacttcctc ctattacccg      180

ccggcgggcg gtggctacgg ccgagcggcg ccctgcgact acgggccggc gccggccttc      240

taccgcgaga aagagtcggc ctgcgcactc tccggcgccg acgagcagcc cccgttccac      300

cccgagccgc ggaagtcgga ctgcgcgcag gacaagagcg tgttcggcga gacagaagag      360

cagaagtgct ccactccggt ctacccgtgg atgcagcgga tgaattcgtg caacagttcc      420

tcctttgggc ccagcggccg gcgaggccgc cagacataca cacgttacca gacgctggag      480

ctggagaagg agtttcacta caatcgctac ctgacgcggc ggcggcgcat cgagatcgcg      540

cacgccctgt gcctgacgga gaggcagatc aagatatggt tccagaaccg acgcatgaag      600

tggaaaaagg agagcaaact gctcagcgcg tctcagctca gtgccgagga ggaggaagaa      660

aaacaggccg agtga                                                       675


<210>  70
<211>  2523
<212>  DNA
<213>  Homo sapiens

<400>  70
atgtcggtgg tgggcataga cctgggcttc cagagctgct acgtcgctgt ggcccgcgcc       60

ggcggcatcg agactatcgc taatgagtat agcgaccgct gcacgccggc ttgcatttct      120

tttggtccta agaatcgttc aattggagca gcagctaaaa gccaggtaat ttctaatgca      180

aagaacacag tccaaggatt taaaagattc catggccgag cattctctga tccatttgtg      240

gaggcagaaa aatctaacct tgcatatgat attgtgcagt tgcctacagg attaacaggt      300

ataaaggtga catatatgga ggaagagcga aattttacca ctgagcaagt gactgccatg      360

cttttgtcca aactgaagga gacagccgaa agtgttctta agaagcctgt agttgactgt      420

gttgtttcgg ttccttgttt ctatactgat gcagaaagac gatcagtgat ggatgcaaca      480

cagattgctg gtcttaattg cttgcgatta atgaatgaaa ccactgcagt tgctcttgca      540

tatggaatct ataagcagga tcttcctgcc ttagaagaga aaccaagaaa tgtagttttt      600

gtagacatgg gccactctgc ttatcaagtt tctgtatgtg catttaatag aggaaaactg      660

aaagttctgg ccactgcatt tgacacgaca ttgggaggta gaaaatttga tgaagtgtta      720

gtaaatcact tctgtgaaga atttgggaag aaatacaagc tagacattaa gtccaaaatc      780

cgtgcattat tacgactctc tcaggagtgt gagaaactca agaaattgat gagtgcaaat      840

gcttcagatc tccctttgag cattgaatgt tttatgaatg atgttgatgt atctggaact      900

atgaatagag gcaaatttct ggagatgtgc aatgatctct tagctagagt ggagccacca      960

cttcgtagtg ttttggaaca aaccaagtta aagaaagaag atatttatgc agtggagata     1020

gttggtggtg ctacacgaat ccctgcggta aaagagaaga tcagcaaatt tttcggtaaa     1080

gaacttagta caacattaaa tgctgatgaa gctgtcactc gaggctgtgc attgcagtgt     1140

gccatcttat cgcctgcttt caaagtcaga gaattttcta tcactgatgt agtaccatat     1200

ccaatatctc tgagatggaa ttctccagct gaagaagggt caagtgactg tgaagtcttt     1260

tccaaaaatc atgctgctcc tttctctaaa gttcttacat tttatagaaa ggaacctttc     1320

actcttgagg cctactacag ctctcctcag gatttgccct atccagatcc tgctatagct     1380

cagttttcag ttcagaaagt cactcctcag tctgatggct ccagttcaaa agtgaaagtc     1440

aaagttcgag taaatgtcca tggcattttc agtgtgtcca gtgcatcttt agtggaggtt     1500

cacaagtctg aggaaaatga ggagccaatg gaaacagatc agaatgcaaa ggaggaagag     1560

aagatgcaag tggaccagga ggaaccacat gttgaagagc aacagcagca gacaccagca     1620

gaaaataagg cagagtctga agaaatggag acctctcaag ctggatccaa ggataaaaag     1680

atggaccaac caccccaagc caagaaggca aaagtgaaga ccagtactgt ggacctgcca     1740

atcgagaatc agctattatg gcagatagac agagagatgc tcaacttgta cattgaaaat     1800

gagggtaaga tgatcatgca ggataaactg gagaaggagc ggaatgatgc taagaacgca     1860

gtggaggaat atgtgtatga aatgagagac aagcttagtg gtgaatatga gaagtttgtg     1920

agtgaagatg atcgtaacag ttttactttg aaactggaag atactgaaaa ttggttgtat     1980

gaggatggag aagaccagcc aaagcaagtt tatgttgata agttggctga attaaaaaat     2040

ctaggtcaac ctattaagat acgtttccag gaatctgaag aacgaccaaa attatttgaa     2100

gaactaggga aacagatcca acagtatatg aaaataatca gctctttcaa aaacaaggag     2160

gaccagtatg atcatttgga tgctgctgac atgacaaagg tagaaaaaag cacaaatgaa     2220

gcaatggagt ggatgaataa caagctaaat ctgcagaaca agcagagttt gaccatggat     2280

ccagttgtca agtcaaaaga gattgaagct aaaattaagg agctgacaag tacttgtagc     2340

cctataattt caaagcccaa acccaaagtg gaacctccaa aagaggaaca aaaaaatgca     2400

gagcagaatg gaccagtgga tggacaagga gacaacccag gcccccaggc tgctgagcag     2460

ggtacagaca cagctgtgcc ttcggattca gacaagaagc ttcctgaaat ggacattgat     2520

tga                                                                   2523


<210>  71
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  71
atgaaggcgc tgagcccggt gcgcggctgc tacgaggcgg tgtgctgcct gtcggaacgc       60

agtctggcca tcgcccgggg ccgagggaag ggcccggcag ctgaggagcc gctgagcttg      120

ctggacgaca tgaaccactg ctactcccgc ctgcgggaac tggtacccgg agtcccgaga      180

ggcactcagc ttagccaggt ggaaatccta cagcgcgtca tcgactacat tctcgacctg      240

caggtagtcc tggccgagcc agcccctgga ccccctgatg gcccccacct tcccatccag      300

acagccgagc tcactccgga acttgtcatc tccaacgaca aaaggagctt ttgccactga      360


<210>  72
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400>  72
atgagtacaa atggtgatga tcatcaggtc aaggatagtc tggagcaatt gagatgtcac       60

tttacatggg agttatccat tgatgacgat gaaatgcctg atttagaaaa cagagtcttg      120

gatcagattg aattcctaga caccaaatac agtgtgggaa tacacaacct actagcctat      180

gtgaaacacc tgaaaggcca gaatgaggaa gccctgaaga gcttaaaaga agctgaaaac      240

ttaatgcagg aagaacatga caaccaagca aatgtgagga gtctggtgac ctggggcaac      300

tttgcctgga tgtattacca catgggcaga ctggcagaag cccagactta cctggacaag      360

gtggagaaca tttgcaagaa gctttcaaat cccttccgct atagaatgga gtgtccagaa      420

atagactgtg aggaaggatg ggccttgctg aagtgtggag gaaaaaatta tgaacgggcc      480

aaggcctgct ttgaaaaggt gcttgaagtg gaccctgaaa accctgaatc cagcgctggg      540

tatgcgatct ctgcctatcg cctggatggc tttaaattag ccacaaaaaa tcacaagcca      600

ttttctttgc ttcccctaag gcaggctgtc cgcttaaatc cagacaatgg atatattaag      660

gttctccttg ccctgaagct tcaggatgaa ggacaggaag ctgaaggaga aaagtacatt      720

gaagaagctc tagccaacat gtcctcacag acctatgtct ttcgatatgc agccaagttt      780

taccgaagaa aaggctctgt ggataaagct cttgagttat taaaaaaggc cttgcaggaa      840

acacccactt ctgtcttact gcatcaccag atagggcttt gctacaaggc acaaatgatc      900

caaatcaagg aggctacaaa agggcagcct agagggcaga acagagaaaa gctagacaaa      960

atgataagat cagccatatt tcattttgaa tctgcagtgg aaaaaaagcc cacatttgag     1020

gtggctcatc tagacctggc aagaatgtat atagaagcag gcaatcacag aaaagctgaa     1080

gagaattttc aaaaattgtt atgcatgaaa ccagtggtag aagaaacaat gcaagacata     1140

catttccact atggtcggtt tcaggaattt caaaagaaat ctgacgtcaa tgcaattatc     1200

cattatttaa aagctataaa aatagaacag gcatcattaa caagggataa aagtatcaat     1260

tctttgaaga aattggtttt aaggaaactt cggagaaagg cattagatct ggaaagcttg     1320

agcctccttg ggttcgtcta caaattggaa ggaaatatga atgaagccct ggagtactat     1380

gagcgggccc tgagactggc tgctgacttt gagaactctg tgagacaagg tccttag        1437


<210>  73
<211>  1014
<212>  DNA
<213>  Homo sapiens

<400>  73
atgcgaccga cgctgctgtg gtcgctgctg ctgctgctcg gagtcttcgc cgccgccgcc       60

gcggccccgc cagaccctct ttcccagctg cccgctcctc agcacccgaa gattcgcctg      120

tacaacgcag agcaggtcct gagttgggag ccagtggccc tgagcaatag cacgaggcct      180

gttgtctacc aagtgcagtt taaatacacc gacagtaaat ggttcacggc cgacatcatg      240

tccatagggg tgaattgtac acagatcaca gcaacagagt gtgacttcac tgccgccagt      300

ccctcagcag gcttcccaat ggatttcaat gtcactctac gccttcgagc tgagctggga      360

gcactccatt ctgcctgggt gacaatgcct tggtttcaac actatcggaa tgtgactgtc      420

gggcctccag aaaacattga ggtgacccca ggagaaggct ccctcatcat caggttctcc      480

tctccctttg acatcgctga tacctccacg gccttttttt gttattatgt ccattactgg      540

gaaaaaggag gaatccaaca ggtcaaaggc cctttcagaa gcaactccat ttcattggat      600

aacttaaaac cctccagagt gtactgttta caagtccagg cacaactgct ttggaacaaa      660

agtaacatct ttagagtcgg gcatttaagc aacatatctt gctacgaaac aatggcagat      720

gcctccactg agcttcagca agtcatcctg atctccgtgg gaacattttc gttgctgtcg      780

gtgctggcag gagcctgttt cttcctggtc ctgaaatata gaggcctgat taaatactgg      840

tttcacactc caccaagcat cccattacag atagaagagt atttaaaaga cccaactcag      900

cccatcttag aggccttgga caaggacagc tcaccaaagg atgacgtctg ggactctgtg      960

tccattatct cgtttccgga aaaggagcaa gaagatgttc tccaaacgct ttga           1014


<210>  74
<211>  1380
<212>  DNA
<213>  Homo sapiens

<400>  74
atgacaattc taggtacaac ttttggcatg gttttttctt tacttcaagt cgtttctgga       60

gaaagtggct atgctcaaaa tggagacttg gaagatgcag aactggatga ctactcattc      120

tcatgctata gccagttgga agtgaatgga tcgcagcact cactgacctg tgcttttgag      180

gacccagatg tcaacatcac caatctggaa tttgaaatat gtggggccct cgtggaggta      240

aagtgcctga atttcaggaa actacaagag atatatttca tcgagacaaa gaaattctta      300

ctgattggaa agagcaatat atgtgtgaag gttggagaaa agagtctaac ctgcaaaaaa      360

atagacctaa ccactatagt taaacctgag gctccttttg acctgagtgt cgtctatcgg      420

gaaggagcca atgactttgt ggtgacattt aatacatcac acttgcaaaa gaagtatgta      480

aaagttttaa tgcacgatgt agcttaccgc caggaaaagg atgaaaacaa atggacgcat      540

gtgaatttat ccagcacaaa gctgacactc ctgcagagaa agctccaacc ggcagcaatg      600

tatgagatta aagttcgatc catccctgat cactatttta aaggcttctg gagtgaatgg      660

agtccaagtt attacttcag aactccagag atcaataata gctcagggga gatggatcct      720

atcttactaa ccatcagcat tttgagtttt ttctctgtcg ctctgttggt catcttggcc      780

tgtgtgttat ggaaaaaaag gattaagcct atcgtatggc ccagtctccc cgatcataag      840

aagactctgg aacatctttg taagaaacca agaaaaaatt taaatgtgag tttcaatcct      900

gaaagtttcc tggactgcca gattcatagg gtggatgaca ttcaagctag agatgaagtg      960

gaaggttttc tgcaagatac gtttcctcag caactagaag aatctgagaa gcagaggctt     1020

ggaggggatg tgcagagccc caactgccca tctgaggatg tagtcatcac tccagaaagc     1080

tttggaagag attcatccct cacatgcctg gctgggaatg tcagtgcatg tgacgcccct     1140

attctctcct cttccaggtc cctagactgc agggagagtg gcaagaatgg gcctcatgtg     1200

taccaggacc tcctgcttag ccttgggact acaaacagca cgctgccccc tccattttct     1260

ctccaatctg gaatcctgac attgaaccca gttgctcagg gtcagcccat tcttacttcc     1320

ctgggatcaa atcaagaaga agcatatgtc accatgtcca gcttctacca aaaccagtga     1380


<210>  75
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  75
atggtgcgga agcttaagtt ccacgagcag aagctgctga agcaggtgga cttcctgaac       60

tgggaggtca ccgaccacaa cctgcacgag ctgcgcgtgc tgcggcgtta ccggctgcag      120

cggcgggagg actacacgcg ctacaaccag ctgagccgtg ccgtgcgtga gctggcgcgg      180

cgcctgcgcg acctgcccga acgcgaccag ttccgcgtgc gcgcttcggc cgcgctgctg      240

gacaagctgt atgctctcgg cttggtgccc acgcgcggtt cgctggagct ctgcgacttc      300

gtcacggcct cgtccttctg ccgccgccgc ctccccaccg tgctcctcaa gctgcgcatg      360

gcgcagcacc ttcaggctgc cgtggccttt gtggagcaag ggcacgtacg cgtgggccct      420

gacgtggtta ccgaccccgc cttccttgtc acgcgcagca tggaggactt tgtcacttgg      480

gtggactcgt ccaagatcaa gcggcacgtg ctagagtaca atgaggagcg cgatgacttc      540

gatctggaag cctag                                                       555


<210>  76
<211>  1800
<212>  DNA
<213>  Homo sapiens

<400>  76
atggaggggc cactcactcc accaccgctg cagggaggcg gagccgccgc tgttccggag       60

cccggagccc ggcaacaccc gggacacgag acggcggcgc agcggtacag cgcccgactg      120

ctgcaggccg gctacgagcc cgagagccct agattggacc tcgctacaca cccgacgaca      180

ccccgttcag aactatcttc agtggtctta ctggcaggtg ttggtgtcca gatggatcgc      240

cttcgcaggg ctagcatggc ggactacctg atcagcggcg gcaccggcta cgtgcccgag      300

gatgggctca ccgcgcagca gctcttcgcc agcgccgacg gcctcaccta caacgacttc      360

ctgattctcc caggattcat agacttcata gctgatgagg tggacctgac ctcagccctg      420

acccggaaga tcacgctgaa gacgccactg atctcctccc ccatggacac tgtgacagag      480

gctgacatgg ccattgccat ggctctgatg ggaggtattg gtttcattca ccacaactgc      540

accccagagt tccaggccaa cgaggtgcgg aaggtcaaga agtttgaaca gggcttcatc      600

acggaccctg tggtgctgag cccctcgcac actgtgggcg atgtgctgga ggccaagatg      660

cggcatggct tctctggcat ccccatcact gagacgggca ccatgggcag caagctggtg      720

ggcatcgtca cctcccgaga catcgacttt cttgctgaga aggaccacac caccctcctc      780

agtgaggtga tgacgccaag gattgaactg gtggtggctc cagcaggtgt gacgttgaaa      840

gaggcaaatg agatcctgca gcgtagcaag aaagggaagc tgcctatcgt caatgattgc      900

gatgagctgg tggccatcat cgcccgcacc gacctgaaga agaaccgaga ctaccctctg      960

gcctccaagg attcccagaa gcagctgctc tgtggggcag ctgtgggcac ccgtgaggat     1020

gacaaatacc gtctggacct gctcacccag gcgggcgtcg acgtcatagt cttggactcg     1080

tcccaaggga attcggtgta tcagatcgcc atggtgcatt acatcaaaca gaagtacccc     1140

cacctccagg tgattggggg gaacgtggtg acagcagccc aggccaagaa cctgattgat     1200

gctggtgtgg acgggctgcg cgtgggcatg ggctgcggct ccatctgcat cacccaggaa     1260

gtgatggcct gtggtcggcc ccagggcact gctgtgtaca aggtggctga gtatgcccgg     1320

cgctttggtg tgcccatcat agccgatggc ggcatccaga ccgtgggaca cgtggtcaag     1380

gccctggccc ttggagcctc cacagtgatg atgggctccc tgctggccgc cactacggag     1440

gcccctggcg agtacttctt ctcagacggg gtgcggctca agaagtaccg gggcatgggc     1500

tcactggatg ccatggagaa gagcagcagc agccagaaac gatacttcag cgagggggat     1560

aaagtgaaga tcgcgcaggg tgtctcgggc tccatccagg acaaaggatc cattcagaag     1620

ttcgtgccct acctcatagc aggcatccaa cacggctgcc aggatatcgg ggcccgcagc     1680

ctgtctgtcc ttcggtccat gatgtactca ggagagctca agtttgagaa gcggaccatg     1740

tcggcccaga ttgagggtgg tgtccatggc ctgcactctt acgaaaagcg gctgtactga     1800


<210>  77
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  77
atgtcagata tcctccggga gctgctctgt gtctctgaga aggctgctaa cattgcccgg       60

gcgtgcagac agcaggaagc cctcttccag ctgctgatcg aagaaaagaa agagggagaa      120

aagaacaaga agtttgcagt tgacttcaag acgctggctg atgtactggt acaggaagtt      180

ataaaacaga atatggagaa caagtttcca ggcttggaaa aaaatatttt tggagaagaa      240

tccaatgagt ttactaatga ctggggggaa aagattacct tgaggttgtg ttcaacagag      300

gaggaaacag cagagcttct tagcaaagtc ctcaatggta acaaggtggc atctgaagca      360

ttagccaggg ttgttcatca ggatgttgcc tttactgacc caactctgga ttccacagag      420

atcaatgttc cacaggacat tttgggaatt tgggtggacc ccatagattc aacttatcag      480

tatataaaag gttctgctga cattaaatcc aaccagggaa tcttcccctg tggacttcag      540

tgtgtcacca ttttaattgg tgtctatgac atacagacag gggttcccct gatgggagtc      600

atcaatcaac cttttgtgtc acgagatcca aacaccctca ggtggaaagg acagtgctat      660

tggggccttt cttacatggg gaccaacatg cattcactac agctcaccat ctctagaaga      720

aacggcagtg aaacacacac tggaaacacc ggctctgagg cagcattctc ccccagtttt      780

tcagccgtaa ttagtacaag tgaaaaggag actatcaaag ctgcattgtc acgtgtgtgt      840

ggagatcgca tatttggggc agctggggct ggttataaga gcctatgtgt tgtccaaggc      900

ctcgttgaca tttacatctt ttcagaagat accacattca aatgggactc ttgtgctgct      960

catgccatac tgagggccat gggtggggga atagtagact tgaaagaatg cttagaaaga     1020

aatccagaaa cagggcttga tttgccacag ttggtgtacc acgtggaaaa tgagggtgct     1080

gctggggtgg atcggtgggc caacaaggga ggactcattg catacagatc caggaagcgg     1140

ctggagacat tcctgagcct cctggtccaa aacctggcac ctgcagagac gcatacctag     1200


<210>  78
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  78
atggctggga gccgtgaggt ggtggccatg gactgcgaga tggtggggct ggggccccac       60

cgggagagtg gcctggctcg ttgcagcctc gtgaacgtcc acggtgctgt gctgtacgac      120

aagttcatcc ggcctgaggg agagatcacc gattacagaa cccgggtcag cggggtcacc      180

cctcagcaca tggtgggggc cacaccattt gccgtggcca ggctagagat cctgcagctc      240

ctgaaaggca agctggtggt gggtcatgac ctgaagcacg acttccaggc actgaaagag      300

gacatgagcg gctacacaat ctacgacacg tccactgaca ggctgttgtg gcgtgaggcc      360

aagctggacc actgcaggcg tgtctccctg cgggtgctga gtgagcgcct cctacacaag      420

agcatccaga acagcctgct tggacacagc tcggtggaag atgcgagggc aacgatggag      480

ctctatcaaa tctcccagag aatccgagcc cgccgagggc tgccccgcct ggctgtgtca      540

gactga                                                                 546


<210>  79
<211>  3492
<212>  DNA
<213>  Homo sapiens

<400>  79
atgaccagga ccagggcagc actcctcctg ttcacagcct tagcaacttc tctaggtttc       60

aacttggaca cagaggagct gacagccttc cgtgtggaca gcgctgggtt tggagacagc      120

gtggtccagt atgccaactc ctgggtggtg gttggagccc cccaaaagat aacagctgcc      180

aaccaaacgg gtggcctcta ccagtgtggc tacagcactg gtgcctgtga gcccatcggc      240

ctgcaggtgc ccccggaggc cgtgaacatg tccctgggcc tgtccctggc gtctaccacc      300

agcccttccc agctgctggc ctgcggcccc accgtgcacc acgagtgcgg gaggaacatg      360

tacctcaccg gactctgctt cctcctgggc cccacccagc tcacccagag gctcccggtg      420

tccaggcagg agtgcccaag acaggagcag gacattgtgt tcctgatcga tggctcaggc      480

agcatctcct cccgcaactt tgccacgatg atgaacttcg tgagagctgt gataagccag      540

ttccagagac ccagcaccca gttttccctg atgcagttct ccaacaaatt ccaaacacac      600

ttcactttcg aggaattcag gcgcagctca aaccccctca gcctgttggc ttctgttcac      660

cagctgcaag ggtttacata cacggccacc gccatccaaa atgtcgtgca ccgattgttc      720

catgcctcat atggggcccg tagggatgcc gccaaaattc tcattgtcat cactgatggg      780

aagaaagaag gcgacagcct ggattataag gatgtcatcc ccatggctga tgcagcaggc      840

atcatccgct atgcaattgg ggttggatta gcttttcaaa acagaaattc ttggaaagaa      900

ttaaatgaca ttgcatcgaa gccctcccag gaacacatat ttaaagtgga ggactttgat      960

gctctgaaag atattcaaaa ccaactgaag gagaagatct ttgccattga gggtacggag     1020

accacaagca gtagctcctt cgaattggag atggcacagg agggcttcag cgctgtgttc     1080

acacctgatg gccccgttct gggggctgtg gggagcttca cctggtctgg aggtgccttc     1140

ctgtaccccc caaatatgag ccctaccttc atcaacatgt ctcaggagaa tgtggacatg     1200

agggactctt acctgggtta ctccaccgag ctggccctct ggaaaggggt gcagagcctg     1260

gtcctggggg ccccccgcta ccagcacacc gggaaggctg tcatcttcac ccaggtgtcc     1320

aggcaatgga ggatgaaggc cgaagtcacg gggactcaga tcggctccta cttcggggcc     1380

tccctctgct ccgtggacgt agacagcgac ggcagcaccg acctggtcct catcggggcc     1440

ccccattact acgagcagac ccgagggggc caggtgtctg tgtgtccctt gcccaggggg     1500

tggagaaggt ggtggtgtga tgctgttctc tacggggagc agggccaccc ctggggtcgc     1560

tttggggcgg ctctgacagt gctgggggat gtgaatgggg acaagctgac agacgtggtc     1620

atcggggccc caggagagga ggagaaccgg ggtgctgtct acctgtttca cggagtcttg     1680

ggacccagca tcagcccctc ccacagccag cggatcgcgg gctcccagct ctcctccagg     1740

ctgcagtatt ttgggcaggc actgagcggg ggtcaagacc tcacccagga tggactggtg     1800

gacctggctg tgggggcccg gggccaggtg ctcctgctca ggaccagacc tgtgctctgg     1860

gtgggggtga gcatgcagtt catacctgcc gagatcccca ggtctgcgtt tgagtgtcgg     1920

gagcaggtgg tctctgagca gaccctggta cagtccaaca tctgccttta cattgacaaa     1980

cgttctaaga acctgcttgg gagccgtgac ctccaaagct ctgtgacctt ggacctggcc     2040

ctcgaccctg gccgcctgag tccccgtgcc accttccagg aaacaaagaa ccggagtctg     2100

agccgagtcc gagtcctcgg gctgaaggca cactgtgaaa acttcaacct gctgctcccg     2160

agctgcgtgg aggactctgt gacccccatt accttgcgtc tgaacttcac gctggtgggc     2220

aagcccctcc ttgccttcag aaacctgcgg cctatgctgg ccgccgatgc tcagagatac     2280

ttcacggcct ccctaccctt tgagaagaac tgtggagccg accatatctg ccaggacaat     2340

ctcggcatct ccttcagctt cccaggcttg aagtccctgc tggtggggag taacctggag     2400

ctgaacgcag aagtgatggt gtggaatgac ggggaagact cctacggaac caccatcacc     2460

ttctcccacc ccgcaggact gtcctaccgc tacgtggcag agggccagaa acaagggcag     2520

ctgcgttccc tgcacctgac atgtgacagc gccccagttg ggagccaggg cacctggagc     2580

accagctgca gaatcaacca cctcatcttc cgtggcggcg cccagatcac cttcttggct     2640

acctttgacg tctcccccaa ggctgtcctg ggagaccggc tgcttctgac agccaatgtg     2700

agcagtgaga acaacactcc caggaccagc aagaccacct tccagctgga gctcccggtg     2760

aagtatgctg tctacactgt ggttagcagc cacgaacaat tcaccaaata cctcaacttc     2820

tcagagtctg aggagaagga aagccatgtg gccatgcaca gataccaggt caataacctg     2880

ggacagaggg acctgcctgt cagcatcaac ttctgggtgc ctgtggagct gaaccaggag     2940

gctgtgtgga tggatgtgga ggtctcccac ccccagaacc catcccttcg gtgctcctca     3000

gagaaaatcg cacccccagc atctgacttc ctggcgcaca ttcagaagaa tcccgtgctg     3060

gactgctcca ttgctggctg cctgcggttc cgctgtgacg tcccctcctt cagcgtccag     3120

gaggagctgg atttcaccct gaagggcaac ctcagctttg gctgggtccg ccagatattg     3180

cagaagaagg tgtcggtcgt gagtgtggct gaaattacgt tcgacacatc cgtgtactcc     3240

cagcttccag gacaggaggc atttatgaga gctcagacga caacggtgct ggagaagtac     3300

aaggtccaca accccacccc cctcatcgta ggcagctcca ttgggggtct gttgctgctg     3360

gcactcatca cagcggtact gtacaaagtt ggcttcttca agcgtcagta caaggaaatg     3420

atggaggagg caaatggaca aattgcccca gaaaacggga cacagacccc cagcccgccc     3480

agtgagaaat ga                                                         3492


<210>  80
<211>  2397
<212>  DNA
<213>  Homo sapiens

<400>  80
atgaatttac aaccaatttt ctggattgga ctgatcagtt cagtttgctg tgtgtttgct       60

caaacagatg aaaatagatg tttaaaagca aatgccaaat catgtggaga atgtatacaa      120

gcagggccaa attgtgggtg gtgcacaaat tcaacatttt tacaggaagg aatgcctact      180

tctgcacgat gtgatgattt agaagcctta aaaaagaagg gttgccctcc agatgacata      240

gaaaatccca gaggctccaa agatataaag aaaaataaaa atgtaaccaa ccgtagcaaa      300

ggaacagcag agaagctcaa gccagaggat attactcaga tccaaccaca gcagttggtt      360

ttgcgattaa gatcagggga gccacagaca tttacattaa aattcaagag agctgaagac      420

tatcccattg acctctacta ccttatggac ctgtcttact caatgaaaga cgatttggag      480

aatgtaaaaa gtcttggaac agatctgatg aatgaaatga ggaggattac ttcggacttc      540

agaattggat ttggctcatt tgtggaaaag actgtgatgc cttacattag cacaacacca      600

gctaagctca ggaacccttg cacaagtgaa cagaactgca ccagcccatt tagctacaaa      660

aatgtgctca gtcttactaa taaaggagaa gtatttaatg aacttgttgg aaaacagcgc      720

atatctggaa atttggattc tccagaaggt ggtttcgatg ccatcatgca agttgcagtt      780

tgtggatcac tgattggctg gaggaatgtt acacggctgc tggtgttttc cacagatgcc      840

gggtttcact ttgctggaga tgggaaactt ggtggcattg ttttaccaaa tgatggacaa      900

tgtcacctgg aaaataatat gtacacaatg agccattatt atgattatcc ttctattgct      960

caccttgtcc agaaactgag tgaaaataat attcagacaa tttttgcagt tactgaagaa     1020

tttcagcctg tttacaagga gctgaaaaac ttgatcccta agtcagcagt aggaacatta     1080

tctgcaaatt ctagcaatgt aattcagttg atcattgatg catacaattc cctttcctca     1140

gaagtcattt tggaaaacgg caaattgtca gaaggcgtaa caataagtta caaatcttac     1200

tgcaagaacg gggtgaatgg aacaggggaa aatggaagaa aatgttccaa tatttccatt     1260

ggagatgagg ttcaatttga aattagcata acttcaaata agtgtccaaa aaaggattct     1320

gacagcttta aaattaggcc tctgggcttt acggaggaag tagaggttat tcttcagtac     1380

atctgtgaat gtgaatgcca aagcgaaggc atccctgaaa gtcccaagtg tcatgaagga     1440

aatgggacat ttgagtgtgg cgcgtgcagg tgcaatgaag ggcgtgttgg tagacattgt     1500

gaatgcagca cagatgaagt taacagtgaa gacatggatg cttactgcag gaaagaaaac     1560

agttcagaaa tctgcagtaa caatggagag tgcgtctgcg gacagtgtgt ttgtaggaag     1620

agggataata caaatgaaat ttattctggc aaattctgcg agtgtgataa tttcaactgt     1680

gatagatcca atggcttaat ttgtggagga aatggtgttt gcaagtgtcg tgtgtgtgag     1740

tgcaacccca actacactgg cagtgcatgt gactgttctt tggatactag tacttgtgaa     1800

gccagcaacg gacagatctg caatggccgg ggcatctgcg agtgtggtgt ctgtaagtgt     1860

acagatccga agtttcaagg gcaaacgtgt gagatgtgtc agacctgcct tggtgtctgt     1920

gctgagcata aagaatgtgt tcagtgcaga gccttcaata aaggagaaaa gaaagacaca     1980

tgcacacagg aatgttccta ttttaacatt accaaggtag aaagtcggga caaattaccc     2040

cagccggtcc aacctgatcc tgtgtcccat tgtaaggaga aggatgttga cgactgttgg     2100

ttctatttta cgtattcagt gaatgggaac aacgaggtca tggttcatgt tgtggagaat     2160

ccagagtgtc ccactggtcc agacatcatt ccaattgtag ctggtgtggt tgctggaatt     2220

gttcttattg gccttgcatt actgctgata tggaagcttt taatgataat tcatgacaga     2280

agggagtttg ctaaatttga aaaggagaaa atgaatgcca aatgggacac gggtgaaaat     2340

cctatttata agagtgccgt aacaactgtg gtcaatccga agtatgaggg aaaatga        2397


<210>  81
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  81
atgagtcttc ttatgattag tgagaatgta aaattggctc gtgaatatgc attgctggga       60

aactatgact ctgcgatggt ctattatcag ggagttcttg accaaatgaa caagtatctg      120

tactcagtca aagatacata cctccagcag aaatggcaac aggtttggca ggaaataaat      180

gtggaagcta aacatgttaa agatatcatg aaaacactag agagctttaa actggacagc      240

actcccttga aagcggcaca gcatgacctt ccagcttctg agggagaagt ctggtccatg      300

cctgtacctg ttgaacgaag accctcacca ggacctagaa aacgccaatc ttctcagtac      360

agtgacccta aatcacatgg taatcgtcca agtacaactg tcagagttca ccgttcatct      420

gcacagaatg ttcacaatga cagagggaaa gctgttcgtt gtcgtgaaaa gaaagaacag      480

aataaaggaa gagaggaaaa gaacaaatca cctgctgcag taacagaacc agagacaaat      540

aaatttgata gtaccggata tgataaagac ttagtagaag ctttggaaag agatataatt      600

tcccagaatc ccaatgttcg atgggatgat atcgctgatt tagtagaagc taaaaagttg      660

cttaaggaag ccgtagtgtt accaatgtgg atgcccgaat tctttaaggg cattaggaga      720

ccatggaaag gagtactgat ggtcggccca cctggcacgg ggaagacgct ccttgctaaa      780

gcagtagcta cagaatgcaa gacaacattc ttcaatgtct cttcatcaac tttgacttcc      840

aaatacagag gagaatctga gaagcttgtt cgtcttctgt ttgaaatggc tcgattttat      900

tctccagcca ccatatttat tgatgagata gactccatct gtagtcgccg agggacttct      960

gaagaacatg aagcaagcag aagggtgaaa gcggagctgc tggttcagat ggatggtgtt     1020

ggaggtactt ctgaaaatga tgacccttcc aaaatggtta tggttctggc agctactaat     1080

tttccctggg atatagatga ggctttaaga cgacgccttg agaaacgaat ctatattcct     1140

ttgccgtcag caaaaggcag ggaggagcta ttacgaataa gtctacgtga gttggaattg     1200

gctgatgatg ttgaccttgc aagtatagca gaaaacatgg aaggttattc aggtgcggac     1260

attaccaacg tgtgcaggga tgcgtccttg atggcaatga gaaggcgcat tgaaggtttg     1320

actccagagg aaatccgaaa tctttccaaa gaagaaatgc acatgcctac aactatggag     1380

gatttcgaga tggctttaaa aaaggtttct aagtcagtgt ctgctgcaga cattgaaaga     1440

tacgagaaat ggatatttga gtttggatca tgctaa                               1476


<210>  82
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  82
atggcgctga gtgaacccat cctgccgtcc ttctccactt tcgccagccc gtgccgcgag       60

cgcggcctgc aggagcgctg gccgcgcgcc gaacccgagt ccggcggcac cgacgacgac      120

ctcaacagcg tgctggactt catcctgtcc atggggctgg atggcctggg cgccgaggcc      180

gccccggagc cgccgccgcc gcccccgccg cctgcgttct attaccccga acccggcgcg      240

cccccgccct acagcgcccc cgcgggtggc ctggtgtctg agctgctgcg acccgagctg      300

gatgcgccgc tggggcccgc actgcacggc cgctttctgc tggcgccgcc cggccgcctg      360

gtcaaggccg agccccctga agcggacggc ggcggcggct acggctgcgc ccccgggctg      420

acccgtggac cgcgcggcct caagcgcgag ggcgccccgg gcccggcggc ttcgtgcatg      480

cgaggtcccg ggggccgccc cccgccgccg cccgacacac cgccgctcag ccccgacggc      540

cccgcgcgcc tgcccgcgcc cggtccgcgc gcctccttcc cgccgccttt cggtggccct      600

ggtttcggcg cgcccgggcc cggcctgcat tacgcgccgc ctgcgccccc agccttcggt      660

ctcttcgacg acgcggccgc cgccgcggca gccctgggcc tggcgccccc cgccgcccgc      720

ggtctcctca cgccgcctgc gtccccgctg gagctgctgg aggccaagcc aaagcgcggc      780

cgccgctctt ggccccgcaa acgcaccgcc actcacacct gcagctacgc gggctgcggc      840

aagacctaca ccaagagttc gcatctgaag gcgcatctgc gcacgcacac aggtgagaag      900

ccctaccact gcaactggga cggctgcggc tggaagtttg cgcgctcaga cgagctcacg      960

cgccactacc gaaagcacac gggccaccgg ccattccagt gccatctgtg cgatcgtgcc     1020

ttctcgcgct ccgatcacct ggcgctgcac atgaaacggc acatgtag                  1068


<210>  83
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  83
atgcaagatg aagaaagata catgacattg aatgtacagt caaagaaaag gagttctgcc       60

caaacatctc aacttacatt taaagattat tcagtgacgt tgcactggta taaaatctta      120

ctgggaatat ctggaaccgt gaatggtatt ctcactttga ctttgatctc cttgatcctg      180

ttggtttctc agggagtatt gctaaaatgc caaaaaggaa gttgttcaaa tgccactcag      240

tatgaggaca ctggagatct aaaagtgaat aatggcacaa gaagaaatat aagtaataag      300

gacctttgtg cttcgagatc tgcagaccag acagtactat gccaatcaga atggctcaaa      360

taccaaggga agtgttattg gttctctaat gagatgaaaa gctggagtga cagttatgtg      420

tattgtttgg aaagaaaatc tcatctacta atcatacatg accaacttga aatggctttt      480

atacagaaaa acctaagaca attaaactac gtatggattg ggcttaactt tacctccttg      540

aaaatgacat ggacttgggt ggatggttct ccaatagatt caaagatatt cttcataaag      600

ggaccagcta aagaaaacag ctgtgctgcc attaaggaaa gcaaaatttt ctctgaaacc      660

tgcagcagtg ttttcaaatg gatttgtcag tattag                                696


<210>  84
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  84
atggcggccc ccggcagcgc ccggcgaccc ctgctgctgc tactgctgtt gctgctgctc       60

ggcctcatgc attgtgcgtc agcagcaatg tttatggtga aaaatggcaa cgggaccgcg      120

tgcataatgg ccaacttctc tgctgccttc tcagtgaact acgacaccaa gagtggccct      180

aagaacatga cctttgacct gccatcagat gccacagtgg tgctcaaccg cagctcctgt      240

ggaaaagaga acacttctga ccccagtctc gtgattgctt ttggaagagg acatacactc      300

actctcaatt tcacgagaaa tgcaacacgt tacagcgtcc agctcatgag ttttgtttat      360

aacttgtcag acacacacct tttccccaat gcgagctcca aagaaatcaa gactgtggaa      420

tctataactg acatcagggc agatatagat aaaaaataca gatgtgttag tggcacccag      480

gtccacatga acaacgtgac cgtaacgctc catgatgcca ccatccaggc gtacctttcc      540

aacagcagct tcagccgggg agagacacgc tgtgaacaag acaggccttc cccaaccaca      600

gcgccccctg cgccacccag cccctcgccc tcacccgtgc ccaagagccc ctctgtggac      660

aagtacaacg tgagcggcac caacgggacc tgcctgctgg ccagcatggg gctgcagctg      720

aacctcacct atgagaggaa ggacaacacg acggtgacaa ggcttctcaa catcaacccc      780

aacaagacct cggccagcgg gagctgcggc gcccacctgg tgactctgga gctgcacagc      840

gagggcacca ccgtcctgct cttccagttc gggatgaatg caagttctag ccggtttttc      900

ctacaaggaa tccagttgaa tacaattctt cctgacgcca gagaccctgc ctttaaagct      960

gccaacggct ccctgcgagc gctgcaggcc acagtcggca attcctacaa gtgcaacgcg     1020

gaggagcacg tccgtgtcac gaaggcgttt tcagtcaata tattcaaagt gtgggtccag     1080

gctttcaagg tggaaggtgg ccagtttggc tctgtggagg agtgtctgct ggacgagaac     1140

agcatgctga tccccatcgc tgtgggtggt gccctggcgg ggctggtcct catcgtcctc     1200

atcgcctacc tcgtcggcag gaagaggagt cacgcaggct accagactat ctag           1254


<210>  85
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  85
atgacaccag gtcgctgctg tcttgcggct gacattcagg tagagacgtt catcttcact       60

gacggggaag atgaggccct ggccaggcac acgggcaacg tggtcatcac aaactgctcg      120

gccgcccaca gccgccaggc gctgtcctgc aagatggccg tggagtatga ccgcttcatc      180

gagtccggca ggaagtggtt ctgccacgtg gacgatgaca actacgtcaa cctgcgggcc      240

ctgctgcggc tgctggccag ctacccgcac acgcgggacg tctacgtcgg caagcccagc      300

ctggacaggc ccatccaggc catggagcgg gtcagcgaga acaaggtgcg tcctgtccac      360

ttctggtttg ccacgggcgg cgctggcttc tgcatcagcc gtgggctggc tctgaagatg      420

agcccgtggg ccagcggggg tcacttcatg aatacggctg agcggatccg gctgcctgat      480

gactgcacca tcggctacat cgtggaggcc ctgctgggtg tgcccctcat ccgcagcggc      540

ctcttccact cccacctgga gaacctgcag caggtgccca cctcggagct ccacgagcag      600

gtgacgctga gctacggtat gtttgaaaac aagcggaacg ccgtccacgt gaaggggccc      660

ttctcggtgg aggccgaccc atccaggttc cgctccatcc actgccacct gtacccggac      720

acaccctggt gtccccgcac tgccatcttc tag                                   753


<210>  86
<211>  687
<212>  DNA
<213>  Homo sapiens

<400>  86
atgtgtcatg tcattgtcac ctgtcgctcg atgctctgga ccttgctgag tattgtggtg       60

gcttttgccg agctcattgc cttcatgagt gcagactggc tgatcgggaa agcgaggagc      120

cgcggcggcg tggagccggc gggcccgggc gggggctccc cggagcccta ccaccccacc      180

ctgggcatct acgcccgctg catccggaac ccaggggtgc agcacttcca gcgggacacg      240

ctgtgcgggc cctacgccga gagcttcggc gagatcgcca gcggcttctg gcaggccaca      300

gctattttcc tggctgtggg aatctttatt ctctgcatgg tggccttggt gtccgtcttc      360

accatgtgtg tacagagcat catgaagaaa agcatcttca atgtctgtgg gctgttgcaa      420

ggaattgcag gtctattcct tatcctcggt ttgatactct accctgctgg ctggggttgc      480

cagaaggcca tagactactg tggacattat gcatctgcct acaaacctgg agactgctcc      540

ttgggctggg ccttttatac cgccattggg ggcacagtcc tcactttcat ctgtgctgtc      600

ttctctgcac aagcagaaat tgcaacctct agtgacaaag tacaggaaga aattgaagag      660

gggaaaaatc tgatctgcct cctttag                                          687


<210>  87
<211>  1899
<212>  DNA
<213>  Homo sapiens

<400>  87
atgacgcccg ccctcacagc cctgctctgc cttgggctga gtctgggccc caggacccgc       60

gtgcaggcag ggcccttccc caaacccacc ctctgggctg agccaggctc tgtgatcagc      120

tgggggagcc ccgtgaccat ctggtgtcag gggagcctgg aggcccagga gtaccaactg      180

gataaagagg gaagcccaga gcccttggac agaaataacc cactggaacc caagaacaag      240

gccagattct ccatcccatc catgacacag caccatgcag ggagataccg ctgccactat      300

tacagctctg caggctggtc agagcccagc gaccccctgg agctggtgat gacaggattc      360

tacaacaaac ccaccctctc agccctgccc agccctgtgg tggcctcagg ggggaatatg      420

accctccgat gtggctcaca gaagggatat caccattttg ttctgatgaa ggaaggagaa      480

caccagctcc cccggaccct ggactcacag cagctccaca gtggggggtt ccaggccctg      540

ttccctgtgg gccccgtgac ccccagccac aggtggaggt tcacatgcta ttactattat      600

acaaacaccc cccgggtgtg gtcccacccc agtgaccccc tggagattct gccctcaggc      660

gtgtctagga agccctccct cctgaccctg cagggccctg tcctggcccc tgggcagagc      720

ctgaccctcc agtgtggctc tgatgtcggc tacgacagat ttgttctgta taaggagggg      780

gaacgtgact tcctccagcg ccctggccag cagccccagg ctgggctctc ccaggccaac      840

ttcaccctgg gccctgtgag cccctcccac gggggccagt acaggtgcta tggtgcacac      900

aacctctcct ccgagtggtc ggcccccagc gaccccctga acatcctgat ggcaggacag      960

atctatgaca ccgtctccct gtcagcacag ccgggcccca cagtggcctc aggagagaac     1020

gtgaccctgc tgtgtcagtc acggggttat tttgacactt tccttctgac caaagaaggg     1080

gcagcccatc ccccactgcg tctgagatca atgtacggag ctcataagta ccaggctgaa     1140

ttccccatga gtcctgtgac ctcagcccac gcggggacct acaggtgcta cggctcatac     1200

agctccaacc cccacctgct gtctttcccc agtgagcccc tggaactcat ggtctcagga     1260

cactctggag gctccagcct cccacccaca gggccgccct ccacacctgg tctgggaaga     1320

tacctggagg ttttgattgg ggtctcggtg gccttcgtcc tgctgctctt cctcctcctc     1380

ttcctcctcc tccgacgtca gcgtcacagc aaacacagga catctgacca gagaaagact     1440

gatttccagc gtcctgcagg ggctgcggag acagagccca aggacagggg cctgctgagg     1500

aggtccagcc cagctgctga cgtccaggaa gaaaacctct atgctgccgt gaaggacaca     1560

cagtctgagg acagggtgga gctggacagt cagcagagcc cacacgatga agacccccag     1620

gcagtgacgt atgccccggt gaaacactcc agtcctagga gagaaatggc ctctcctccc     1680

tcctcactgt ctggggaatt cctggacaca aaggacagac aggtggaaga ggacaggcag     1740

atggacactg aggctgctgc atctgaagcc tcccaggatg tgacctacgc ccagctgcac     1800

agcttgaccc ttagacggaa ggcaactgag cctcctccat cccaggaagg ggaacctcca     1860

gctgagccca gcatctacgc cactctggcc atccactag                            1899


<210>  88
<211>  1836
<212>  DNA
<213>  Homo sapiens

<400>  88
atgcccgaga tagtggatac ctgttcgttg gcctctccgg cttccgtctg ccggaccaag       60

cacctgcacc tgcgctgcag cgtcgacttt actcgccgga cgctgaccgg gactgctgct      120

ctcacggtcc agtctcagga ggacaatctg cgcagcctgg ttttggatac aaaggacctt      180

acaatagaaa aagtagtgat caatggacaa gaagtcaaat atgctcttgg agaaagacaa      240

agttacaagg gatcgccaat ggaaatctct cttcctatcg ctttgagcaa aaatcaagaa      300

attgttatag aaatttcttt tgagacctct ccaaaatctt ctgctctcca gtggctcact      360

cctgaacaga cttctgggaa ggaacaccca tatctcttta gtcagtgcca ggccatccac      420

tgcagagcaa tccttccttg tcaggacact ccttctgtga aattaaccta tactgcagag      480

gtgtctgtcc ctaaagaact ggtggcactt atgagtgcta ttcgtgatgg agaaacacct      540

gacccagaag acccaagcag gaaaatatac aaattcatcc aaaaagttcc aataccctgc      600

tacctgattg ctttagttgt tggagcttta gaaagcaggc aaattggccc aagaactttg      660

gtgtggtctg agaaagagca ggtggaaaag tctgcttatg agttttctga gactgaatct      720

atgcttaaaa tagcagaaga tctgggagga ccgtatgtat ggggacagta tgacctattg      780

gtcctgccac catccttccc ttatggtggc atggagaatc cttgccttac ttttgtaact      840

cctactctac tggcaggcga caagtcactc tccaatgtca ttgcacatga aatatctcat      900

agctggacag ggaatctagt gaccaacaaa acttgggatc acttttggtt aaatgaggga      960

catactgtgt acttggaacg ccacatttgc ggacgattgt ttggtgaaaa gttcagacat     1020

tttaatgctc tgggaggatg gggagaacta cagaattcgg taaagacatt tggggagaca     1080

catcctttca ccaaacttgt ggttgatctg acagatatag accctgatgt agcttattct     1140

tcagttccct atgagaaggg ctttgcttta cttttttacc ttgaacaact gcttggagga     1200

ccagagattt tcctaggatt cttaaaagct tatgttgaga agttttccta taagagcata     1260

actactgatg actggaagga tttcctgtat tcctatttta aagataaggt tgatgttctc     1320

aatcaagttg attggaatgc ctggctctac tctcctggac tgcctcccat aaagcccaat     1380

tatgatatga ctctgacaaa tgcttgtatt gccttaagtc aaagatggat tactgccaaa     1440

gaagatgatt taaattcatt caatgccaca gacctgaagg atctctcttc tcatcaattg     1500

aatgagtttt tagcacagac gctccagagg gcacctcttc cattggggca cataaagcga     1560

atgcaagagg tgtacaactt caatgccatt aacaattctg aaatacgatt cagatggctg     1620

cggctctgca ttcaatccaa gtgggaggac gcaattcctt tggcgctaaa gatggcaact     1680

gaacaaggaa gaatgaagtt tacccggccc ttattcaagg atcttgctgc ctttgacaaa     1740

tcccatgatc aagctgtccg aacctaccaa gagcacaaag caagcatgca tcccgtgact     1800

gcaatgctgg tggggaaaga cttaaaagtg gattaa                               1836


<210>  89
<211>  2133
<212>  DNA
<213>  Homo sapiens

<400>  89
atgaaacttg tcttcctcgt cctgctgttc ctcggggccc tcggactgtg tctggctggc       60

cgtaggagga gtgttcagtg gtgcgccgta tcccaacccg aggccacaaa atgcttccaa      120

tggcaaagga atatgagaaa agtgcgtggc cctcctgtca gctgcataaa gagagactcc      180

cccatccagt gtatccaggc cattgcggaa aacagggccg atgctgtgac ccttgatggt      240

ggtttcatat acgaggcagg cctggccccc tacaaactgc gacctgtagc ggcggaagtc      300

tacgggaccg aaagacagcc acgaactcac tattatgccg tggctgtggt gaagaagggc      360

ggcagctttc agctgaacga actgcaaggt ctgaagtcct gccacacagg ccttcgcagg      420

accgctggat ggaatgtccc tatagggaca cttcgtccat tcttgaattg gacgggtcca      480

cctgagccca ttgaggcagc tgtggccagg ttcttctcag ccagctgtgt tcccggtgca      540

gataaaggac agttccccaa cctgtgtcgc ctgtgtgcgg ggacagggga aaacaaatgt      600

gccttctcct cccaggaacc gtacttcagc tactctggtg ccttcaagtg tctgagagac      660

ggggctggag acgtggcttt tatcagagag agcacagtgt ttgaggacct gtcagacgag      720

gctgaaaggg acgagtatga gttactctgc ccagacaaca ctcggaagcc agtggacaag      780

ttcaaagact gccatctggc ccgggtccct tctcatgccg ttgtggcacg aagtgtgaat      840

ggcaaggagg atgccatctg gaatcttctc cgccaggcac aggaaaagtt tggaaaggac      900

aagtcaccga aattccagct ctttggctcc cctagtgggc agaaagatct gctgttcaag      960

gactctgcca ttgggttttc gagggtgccc ccgaggatag attctgggct gtaccttggc     1020

tccggctact tcactgccat ccagaacttg aggaaaagtg aggaggaagt ggctgcccgg     1080

cgtgcgcggg tcgtgtggtg tgcggtgggc gagcaggagc tgcgcaagtg taaccagtgg     1140

agtggcttga gcgaaggcag cgtgacctgc tcctcggcct ccaccacaga ggactgcatc     1200

gccctggtgc tgaaaggaga agctgatgcc atgagtttgg atggaggata tgtgtacact     1260

gcaggcaaat gtggtttggt gcctgtcctg gcagagaact acaaatccca acaaagcagt     1320

gaccctgatc ctaactgtgt ggatagacct gtggaaggat atcttgctgt ggcggtggtt     1380

aggagatcag acactagcct tacctggaac tctgtgaaag gcaagaagtc ctgccacacc     1440

gccgtggaca ggactgcagg ctggaatatc cccatgggcc tgctcttcaa ccagacgggc     1500

tcctgcaaat ttgatgaata tttcagtcaa agctgtgccc ctgggtctga cccgagatct     1560

aatctctgtg ctctgtgtat tggcgacgag cagggtgaga ataagtgcgt gcccaacagc     1620

aacgagagat actacggcta cactggggct ttccggtgcc tggctgagaa tgctggagac     1680

gttgcatttg tgaaagatgt cactgtcttg cagaacactg atggaaataa caatgaggca     1740

tgggctaagg atttgaagct ggcagacttt gcgctgctgt gcctcgatgg caaacggaag     1800

cctgtgactg aggctagaag ctgccatctt gccatggccc cgaatcatgc cgtggtgtct     1860

cggatggata aggtggaacg cctgaaacag gtgttgctcc accaacaggc taaatttggg     1920

agaaatggat ctgactgccc ggacaagttt tgcttattcc agtctgaaac caaaaacctt     1980

ctgttcaatg acaacactga gtgtctggcc agactccatg gcaaaacaac atatgaaaaa     2040

tatttgggac cacagtatgt cgcaggcatt actaatctga aaaagtgctc aacctccccc     2100

ctcctggaag cctgtgaatt cctcaggaag taa                                  2133


<210>  90
<211>  2463
<212>  DNA
<213>  Homo sapiens

<400>  90
atggcgctgc tgcgggatgt gtcgctgcag gacccgcggg accgcttcga gctgctgcag       60

cgcgtggggg ccgggaccta tggcgacgtc tacaaggccc gcgacacggt cacgtccgaa      120

ctggccgccg tgaagatagt caagctagac ccaggggacg acatcagctc cctccagcag      180

gaaatcacca tcctgcgtga gtgccgccac cccaatgtgg tggcctacat tggcagctac      240

ctcaggaatg accgcttgtg gatctgcatg gagttctgcg gagggggctc cctgcaggag      300

atttaccatg ccactgggcc cctggaggag cggcagattg cctacgtctg ccgagaggca      360

ctgaaggggc tccaccacct gcattctcag gggaagatcc acagagacat caagggagcc      420

aaccttctcc tcactctcca gggagatgtc aaactggctg actttggggt gtcaggcgag      480

ctgacagcgt ctgtggccaa gaggaggtct ttcattggga ctccctactg gatggctccc      540

gaggtggctg ctgtggagcg caaaggtggc tacaatgagc tatgtgacgt ctgggccctg      600

ggcatcactg ccattgagct gggcgagctg cagccccctc tgttccacct gcaccccatg      660

agggccctga tgctcatgtc gaagagcagc ttccagccgc ccaaactgag agataagact      720

cgctggaccc agaatttcca ccactttctc aaactggccc tgaccaagaa tcctaagaag      780

aggccgacag cagagaagct cctgcagcac ccgttcacga ctcagcagct ccctcgggcc      840

ctcctcacac agctgctgga caaagccagt gaccctcatc tggggacccc ctcccctgag      900

gactgtgagc tggagaccta tgacatgttt ccagacacca ttcactcccg ggggcagcac      960

ggcccagccg agaggacccc ctcggagatc cagtttcacc aggtgaaatt tggcgcccca     1020

cgcaggaagg aaactgaccc actgaatgag ccgtgggagg aagagtggac actactggga     1080

aaggaagagt tgagtgggag cctgctgcag tcggtccagg aggccctgga ggaaaggagt     1140

ctgactattc ggtcagcctc agaattccag gagctggact ccccagacga taccatggga     1200

accatcaagc gggccccgtt cctagggcca ctccccactg accctccagc agaggagcct     1260

ctgtccagtc ccccaggaac cctgccccca cctccttcag gccccaacag ctccccactg     1320

ctgcccacgg cctgggccac catgaagcag cgggaggatc ctgagaggtc atcctgccac     1380

gggctccccc caactcccaa ggtgcatatg ggcgcctgct tctccaaggt cttcaatggc     1440

tgccccctgc ggatccacgc tgctgtcacc tggattcacc ctgttactcg ggaccagttc     1500

ctggtggtag gggccgagga aggcatctac acactcaacc tgcatgaact gcatgaggat     1560

acgctggaga agctgatttc acatcgctgc tcctggctct actgcgtgaa caacgtgctg     1620

ctgtcactct cagggaaatc cacgcacatc tgggcccatg acctcccagg cctgtttgag     1680

cagcggaggc tacagcaaca ggttcccctc tccatcccca ccaaccgcct cacccagcgc     1740

atcatcccca ggcgctttgc tctgtccacc aagattcctg acaccaaagg ctgcttgcag     1800

tgtcgtgtgg tgcggaaccc ctacacgggt gccaccttcc tgctggccgc cctgcccacc     1860

agcctgctcc tgctgcagtg gtatgagccg ctgcagaagt ttctgctgct gaagaacttc     1920

tccagccctc tgcccagccc agctgggatg ctggagccgc tggtgctgga tgggaaggag     1980

ctgccgcagg tgtgtgttgg ggccgagggg cctgaggggc ccggctgccg cgtcctgttc     2040

catgtcctgc ccctggaggc tggcctgacg cccgacatcc tcatcccacc tgaggggatc     2100

ccaggctcgg cccagcaggt gatccaggtg gacagggaca caatcctagt cagctttgaa     2160

cgctgtgtga ggattgtcaa catgcagggc gagcccacgg ccacactggc acctgagctg     2220

acctttgatt tccccatcga gactgtggtg tgcctgcagg acagtgtgct ggccttctgg     2280

agccatggga tgcaaggccg aagcctggat accaatgagg tgacccagga gatcacagat     2340

gaaacaagga tcttccgagt gcttggggcc cacagagaca tcatcctgga gagcattccc     2400

actgacaacc cagaggcgca cagcaacctc tacatcctca cgggccacca gagcacctac     2460

taa                                                                   2463


<210>  91
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  91
atgtctcagg agaggcccac gttctaccgg caggagctga acaagacaat ctgggaggtg       60

cccgagcgtt accagaacct gtctccagtg ggctctggcg cctatggctc tgtgtgtgct      120

gcttttgaca caaaaacggg gttacgtgtg gcagtgaaga agctctccag accatttcag      180

tccatcattc atgcgaaaag aacctacaga gaactgcggt tacttaaaca tatgaaacat      240

gaaaatgtga ttggtctgtt ggacgttttt acacctgcaa ggtctctgga ggaattcaat      300

gatgtgtatc tggtgaccca tctcatgggg gcagatctga acaacattgt gaaatgtcag      360

aagcttacag atgaccatgt tcagttcctt atctaccaaa ttctccgagg tctaaagtat      420

atacattcag ctgacataat tcacagggac ctaaaaccta gtaatctagc tgtgaatgaa      480

gactgtgagc tgaagattct ggattttgga ctggctcggc acacagatga tgaaatgaca      540

ggctacgtgg ccactaggtg gtacagggct cctgagatca tgctgaactg gatgcattac      600

aaccagacag ttgatatttg gtcagtggga tgcataatgg ccgagctgtt gactggaaga      660

acattgtttc ctggtacaga ccatattaac cagcttcagc agattatgcg tctgacagga      720

acaccccccg cttatctcat taacaggatg ccaagccatg aggcaagaaa ctatattcag      780

tctttgactc agatgccgaa gatgaacttt gcgaatgtat ttattggtgc caatcccctg      840

gctgtcgact tgctggagaa gatgcttgta ttggactcag ataagagaat tacagcggcc      900

caagcccttg cacatgccta ctttgctcag taccacgatc ctgatgatga accagtggcc      960

gatccttatg atcagtcctt tgaaagcagg gacctcctta tagatgagtg gaaaagcctg     1020

acctatgatg aagtcatcag ctttgtgcca ccaccccttg accaagaaga gatggagtcc     1080

tga                                                                   1083


<210>  92
<211>  4011
<212>  DNA
<213>  Homo sapiens

<400>  92
atgatggaga tccagatgga cgagggcggc ggcgtggtgg tgtaccagga cgactactgc       60

tccggctcgg tgatgtcgga gcgggtgtcg ggcctggcgg gctccatcta ccgcgagttc      120

gagcgcctca tccactgcta cgacgaggag gtggtcaagg agctcatgcc gctggtggtg      180

aacgtgctgg agaacctaga ctcggtgctc agcgagaacc aggagcacga ggtggagctg      240

gagctgctgc gcgaggacaa cgagcagctg ctcacccagt acgagcgtga gaaggcgctg      300

cgcaggcagg cggaggagaa attcattgag tttgaagatg ctctggaaca agagaagaaa      360

gagctgcaaa tccaggtgga gcactacgag ttccagacgc gccagctgga gctgaaggcc      420

aagaactatg ccgatcagat ttcccggttg gaggagcggg agtcggagat gaagaaggag      480

tacaatgccc tgcaccagcg gcacacagag atgatacaga cctacgtgga gcacattgag      540

aggtccaaga tgcagcaggt cggaggaaac agccagaccg agagcagcct gccggggcgg      600

aggaaggagc gccccacctc cctgaacgtg ttccccctgg ctgacggcac ggtacgtgca      660

cagatcgggg gcaagctcgt gcctgcgggg gaccactggc acctgagtga cctcggccag      720

ctgcagtcca gctccagcta ccagtgtcca caggatgaaa tgtccgagtc aggccagtcc      780

tcggcggccg ccacacccag caccacaggc accaagtcca acacgcccac atcctccgtg      840

ccctcggccg ccgtcacacc cctcaacgag agcctgcagc ccctggggga ctatggcgtg      900

ggctccaaga acagcaagcg tgcccgggag aagcgcgaca gccgcaacat ggaagtacag      960

gtcacccagg agatgcgcaa cgtcagtata ggcatgggca gcagtgacga gtggtctgat     1020

gttcaagaca ttattgactc cacgccagag ctggacatgt gtccagagac ccgcctggac     1080

cgcacaggaa gcagcccaac ccagggcatc gtgaacaaag ctttcggcat caacaccgac     1140

tccctgtacc atgagctgtc gacggcaggg tctgaggtca tcggggatgt ggacgaaggg     1200

gccgacctcc taggggagtt ctcagtgcgc gatgatttct ttggaatggg caaagaagtg     1260

gggaatctgc tactggaaaa ctcacagctt ctggaaacca aaaacgcctt gaatgtggtg     1320

aagaatgacc tgattgccaa ggtcgaccag ctgtccgggg agcaggaggt gctgaggggc     1380

gagttggagg ctgctaagca ggccaaagtc aagctggaaa accgtatcaa ggagctggaa     1440

gaggaactga aaagagtgaa gtccgaggcc atcatcgccc gccgtgaacc caaagaagag     1500

gcggaggatg taagcagcta tctctgtaca gaatcggaca aaatccccat ggcccagcgc     1560

cgccgcttca cgcgggtgga gatggcccgt gtgctcatgg agcggaacca gtacaaggag     1620

cggctgatgg agctgcagga ggctgtgcgg tggactgaga tgatcagagc gtcccgagag     1680

cacccatccg tccaggagaa gaagaagtcg accatctggc agttcttcag ccgcctcttc     1740

agctcttcct ccagcccccc tccggccaag cgcccctatc cctcggtgaa catccactac     1800

aagtcaccca ccactgccgg cttcagccag cgccgcaacc atgccatgtg cccgatctcg     1860

gcaggcagcc ggcccctgga attcttccct gacgacgact gcacgtcctc cgcccgtcga     1920

gagcagaagc gcgagcagta ccgccaggtg cgtgagcacg tgcgtaacga cgacggccgt     1980

ctgcaggcct gcggctggag cctgcccgcc aagtacaagc agctgagtcc caacgggggc     2040

caggaggaca cgcggatgaa gaacgtgccg gtgccggtgt actgccgccc tctggtggag     2100

aaggacccca ccatgaagct gtggtgtgcc gcgggcgtca acctgagcgg gtggaggccc     2160

aatgaggacg acgctgggaa tggagtcaag ccagcgccag gccgcgatcc cctgacctgc     2220

gaccgcgaag gagacggcga gcccaagagc gcccacacgt ctcccgagaa gaagaaggcc     2280

aaggagctcc ctgaaatgga cgccacctcc agccgggtgt ggatcctgac cagcaccctg     2340

accaccagca aggtggtgat catcgacgcc aaccagccgg gcacggtggt ggaccagttc     2400

accgtctgca acgcgcacgt gctgtgcatc tccagcatcc ccgcggccag cgacagcgac     2460

taccctcccg gggagatgtt cctggacagc gacgtgaacc cagaggaccc gggcgcagat     2520

ggcgtgctgg ccggtatcac cctggtgggc tgtgccaccc gctgcaacgt gccgcggagc     2580

aactgctcct cccgagggga caccccagtg ctagacaagg ggcaggggga ggtggccacc     2640

atcgccaacg ggaaggtcaa cccgtcccag tccacagagg aggccacaga ggccacggag     2700

gtgccagacc ctgggcccag cgagccagag acagccacat tgcggcccgg gcctctcaca     2760

gagcacgtct tcactgaccc agccccgacc ccgtcctctg gcccccagcc tggcagcgag     2820

aacgggccag agcctgacag cagcagcaca cggccagagc cagagcccag cggggacccc     2880

acgggagcag gcagcagtgc tgcacccacc atgtggctgg gagcccagaa cggctggctc     2940

tatgtgcact cggctgtggc caactggaag aagtgcctgc actccatcaa gctgaaggat     3000

tctgtgctga gcctggtgca tgtcaaaggc cgtgtgctgg tggctctggc ggacgggacc     3060

ctggccatct tccaccgtgg tgaagatggc cagtgggatc tgagcaacta tcacctaatg     3120

gacctgggcc acccgcacca ctccatccgc tgcatggctg ttgtgtacga ccgcgtgtgg     3180

tgtggctaca agaacaaggt gcacgtcatc cagcccaaga ccatgcagat agagaagtca     3240

tttgacgccc acccgcggcg ggagagccag gtgcggcagc tggcgtggat cggcgatggc     3300

gtatgggtgt ccatccgcct ggactccacc ctgaggctct accatgcaca cacgcaccag     3360

catctacagg acgtggacat tgagccctac gtcagcaaga tgctaggcac tggcaagctg     3420

ggtttctcct tcgtacgcat cacggccctg cttgtcgcgg gcagccggct ctgggtgggc     3480

accggcaacg gagtggtcat ctccatcccc ctgacagaga ctgtggtcct gcaccgaggc     3540

cagctcctgg ggctccgagc caataagaca tcccccacct ctggggaggg cgcccgtccc     3600

gggggcatca tccacgtgta tggcgatgac agcagtgaca gggcggccag cagcttcatc     3660

ccctactgct ccatggccca ggcccagcta tgcttccatg ggcaccgcga tgccgtgaag     3720

ttctttgtct cggtgccagg gaacgtgctg gccaccctga atgggagtgt gctggacagc     3780

ccagccgagg gccctgggcc agctgcccct gcctcggagg tcgagggcca gaagctgcgg     3840

aacgtgctgg tgctgagcgg cggggagggc tacatcgact tccgcattgg agacggagag     3900

gacgacgaga cggaggaggg cgcaggggac atgagccagg tgaagcccgt gctgtccaag     3960

gcagagcgca gtcacatcat cgtgtggcag gtgtcctaca cccccgagtg a              4011


<210>  93
<211>  3000
<212>  DNA
<213>  Homo sapiens

<400>  93
atggagcccc gggctgccgc ggcgggcgag ccagagccgc cggcggcgtc ctcctccttc       60

caggcccggc tctggaagaa cctgcagctg ggggtgggca ggagcaaggg cggcgggggc      120

gggcgcgctg ggggtccaga gcgccgcact gcggacaccc cgtcgccctc cccgccaccc      180

ccggtgggca cagggaatgc accggccagg gggagtggtg caggcagcag gtggagcggc      240

ttcaagaagc ggaagcaagt gctggaccga gtcttctcct cctcgcagcc caacctgtgc      300

tgctcgtcgc cggagcccct ggagcccggc ggcgccggca gagccgagca ggggtccacg      360

ctacgccgcc ggatccgcga gcatttgctc cccgccgtaa aggggcccgc ggcggcctcg      420

ggagcagcgg gagggacgcc tcctggcgga cgctcccccg actcagctcc ttcctcttcc      480

tccgcctcat cctccctgtc ctcctcgccc cagcctcccc cgagggggga ccgcgcccga      540

gatgagggtg cacggcgtca gggccccggg gcgcacttgt gccaccagaa gagctcctct      600

ctgccgggca ccgcctgcct ggagcagctg ctggagccgc cgcctcctcc cgcagagccg      660

gcgcggagtc ccgcggagtc tcgggccccg gagacgggcg aggagcacgg cagcagccag      720

aaaataataa acactgctgg aaccagtaat gcagaagtcc ccttggctga tcccggaatg      780

taccagctgg acattacatt aagaaggggt caaagtttag ctgctcgaga tcgaggaggg      840

acgagtgatc catatgtgaa gtttaaaatc ggaggaaaag aagtttttag aagtaagata      900

atacacaaga acctcaaccc tgtgtgggaa gaaaaagctt gtattctggt tgatcatctt      960

agggagccat tgtatataaa ggtatttgac tatgattttg gactacagga tgactttatg     1020

ggctcagcct ttctggatct gacacaattg gagttaaaca ggcccacaga tgtgaccctt     1080

actctgaaag atcctcatta tcctgaccat gatcttggaa tcattttgct ctcagtcatc     1140

cttaccccta aagaaggaga gtccagggat gtgacaatgc taatgaggaa gagttggaaa     1200

agatcaagta aggaactttc agaaaatgaa gtggttggat cttatttctc tgtgaagtct     1260

ctcttttgga ggacgtgcgg caggccagct cttcctgtcc tgggcttctg cagagcagag     1320

cttcagaatc cttattgcaa aaatgtacaa tttcagaccc aaagtttacg cctatcagac     1380

ctacacagaa aatcgcatct ttggagagga atagtcagca tcaccttgat tgaagggaga     1440

gacctcaagg ccatggattc caacgggttg agcgatccct acgtgaagtt ccggcttggg     1500

catcagaagt acaagagcaa gattatgcca aaaacgttga atcctcagtg gagggaacaa     1560

tttgattttc acctttatga agaaagagga ggagtcattg atatcactgc atgggacaaa     1620

gatgctggga aaagggatga tttcattggc aggtgccagg tcgacctgtc agccctcagt     1680

agggaacaga cgcacaagct ggagttgcag ctggaagagg gtgagggaca cctggtgctg     1740

ctggtcactc tgacagcatc agccacagtc agcatctctg acctgtctgt caactccctg     1800

gaggaccaga aggaacgaga ggagatatta aagagatata gcccattgag gatatttcac     1860

aacctgaaag atgtgggatt tctccaggtg aaagtcatca gagcggaagg gttaatggct     1920

gccgacgtca ctggaaaaag tgacccattt tgtgtggtag aactgaacaa cgatagactg     1980

ctaacacata ctgtctacaa aaatctcaat cctgagtgga ataaagtctt cacgttcaac     2040

attaaagata tccattcagt tcttgaagtg acagtttatg atgaagatcg ggatcgaagt     2100

gctgactttc tgggcaaagt tgctatacca ttgctgtcta ttcaaaatgg tgaacagaaa     2160

gcctacgtct tgaaaaacaa gcagctgaca gggccaacaa agggggtcat ctatcttgaa     2220

atagatgtga tttttaatgc tgtgaaagcc agcttacgaa cattaatacc caaagaacag     2280

aagtacattg aagaggaaaa cagactctct aaacagctgc tactaagaaa ctttatcaga     2340

atgaaacgtt gtgtcatggt gctggtaaat gctgcatact acgttaatag ttgctttgat     2400

tgggattcac ccccaaggag tctcgctgct tttgtgctct ttctctttgt tgtctggaac     2460

tttgagctct acatgatacc actggttttg ttgttactat tgacatggaa ctacttcttg     2520

ataatatcag ggaaagataa caggcaacgt gatacagtag tggaggacat gctagaggac     2580

gaggaagaag aagatgacaa agatgacaag gacagtgaaa aaaagggatt tataaataaa     2640

atctatgcca tccaggaggt atgtgtcagt gtccagaaca tcctagatga agtggcttcc     2700

tttggcgaaa ggataaagaa tactttcaac tggactgtcc cattcttaag ctggctggcc     2760

attgtagccc tctgtgtgtt cacagccatc ctgtactgca ttccgctgag atacattgtc     2820

cttgtctggg gcatcaataa atttacaaaa aagcttcgga gtccatatgc aattgataac     2880

aatgaactac ttgacttcct ttccagagtc ccttcagatg tacaagtggt gcaataccaa     2940

gaactgaaac cagatccttc tcatagccca tataaaagaa agaaaaacaa tcttggctag     3000


<210>  94
<211>  1809
<212>  DNA
<213>  Homo sapiens

<400>  94
atgaatggcg gagccgagcg cgccatgagg agcctgccga gcctgggcgg cctcgccctg       60

ttgtgctgcg ccgccgccgc cgccgccgcc gccgtcgcct cagccgcctc ggcggggaat      120

gtcaccggtg gcggcggggc cgcggggcag gtggacgcgt cgccgggccc cgggttgcgg      180

ggcgagccca gccacccctt ccctagggcg acggctccca cggcccaggc cccgaggacc      240

gggcccccgc gcgccaccgt ccaccgaccc ctggctgcga cttctccagc ccagtccccg      300

gagaccaccc ctctttgggc gactgctgga ccctcttcca ccacctttca ggcgccgctc      360

ggcccctcgc cgaccacccc tccggcggcg gaacgcactt cgaccacctc tcaggcgccg      420

accagacccg cgccgaccac cctttcgacg accactggcc cggcgccgac cacccctgta      480

gcgaccaccg taccggcgcc cacgactccc cggaccccga cccccgatct ccccagcagc      540

agcaacagca gcgtcctccc caccccacct gccaccgagg ccccctcttc gcctcctcca      600

gagtatgtat gtaactgctc tgtggttgga agcctgaatg tgaatcgctg caaccagacc      660

acagggcagt gtgagtgtcg gccaggttat caggggcttc actgtgaaac ctgcaaagag      720

ggcttttacc taaattacac ttctgggctc tgtcagccat gtgactgtag tccacatgga      780

gctctcagca taccgtgcaa cagttctggg aaatgccagt gcaaagtggg tgtcattggc      840

tctatatgtg accgatgcca agatggatat tatggcttta gtaagaatgg ctgcttgccc      900

tgccaatgca ataatcggtc tgccagttgc gatgccctca caggtgcttg tttaaactgc      960

caggaaaata gcaaaggaaa tcactgtgaa gaatgtaaag aaggatttta tcagagtcct     1020

gatgccacta aagaatgtct tcgctgccct tgttcagcag tgacatctac aggcagctgc     1080

tctataaaat cgagtgaatt ggaacctgaa tgtgaccagt gtaaagatgg ttacataggc     1140

ccgaactgca ataaatgtga aaatggctat tacaattttg acagcatctg tagaaagtgc     1200

caatgtcacg gccatgtgga cccagttaaa actccaaaga tttgtaagcc cgagagtggt     1260

gagtgcatca actgcctcca taacaccact gggttttggt gtgagaactg cctagaaggt     1320

tatgttcacg acctcgaggg aaattgcatc aagaaagaag ttattcttcc aacacctgaa     1380

ggttctacca ttttggtttc caatgcctct ttgaccacat cagtgcccac ccctgttata     1440

aatagtactt ttacccctac aaccctgcag actatctttt cagtaagcac ttctgaaaac     1500

agcacttcag ctttagctga tgtatcatgg acccaattta acatcatcat tttgacagtc     1560

atcatcattg ttgtggtgct gctaatggga tttgtggggg ctgtatatat gtaccgcgag     1620

taccaaaacc ggaaactcaa tgcccccttt tggaccatcg agctgaaaga agacaatatc     1680

agtttcagca gctaccatga cagcattccc aatgcagatg tttcgggatt gttggaagat     1740

gatggcaatg aagtggctcc caatgggcag ctgaccctga cgacgcccat acataactac     1800

aaagcctaa                                                             1809


<210>  95
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  95
atgagactgc tggcgggctg gctgtgcctg agcctggcgt ccgtgtggct ggcgcggagg       60

atgtggacgc tgcggagccc gctcacccgc tccctgtacg tgaacatgac tagcggcccg      120

ggtgggccgg cggcggccgc gggcggcagg aaggagaacc accagtggta tgtgtgcaac      180

agagagaaat tatgcgaatc actccaggct gtctttgttc agagttacct tgatcaagga      240

acacagatct tcttaaacaa cagcattgag aaatcgggct ggctatttat ccaattatat      300

cattcttttg tgtcatctgt ttttagcctg tttatgtcta gaacatctat caatgggttg      360

ctaggaagag gctcaatgtt tgtgttttca ccagatcagt ttcagagact gcttaaaatt      420

aatccagact ggaaaaccca cagacttctt gatttaggtg ctggagatgg agaagtcaca      480

aaaatcatga gccctcattt tgaagaaatc tatgccactg agctttctga aactatgata      540

tggcagcttc agaaaaagaa atacagagtc cttggtataa atgaatggca gaatacgggg      600

ttccagtatg atgtcatcag ctgcctgaac ttgctggacc gctgtgatca gcccctgact      660

ttgttaaaag atatcagaag tgtcttggag ccaactagag gcagggtcat ccttgccctt      720

gtcctcccct ttcatcccta tgtggaaaac gtaggtggca agtgggagaa accatcagaa      780

attttggaaa tcaaaggaca gaactgggaa gaacaagtga atagtctgcc tgaagttttc      840

agaaaagctg gttttgttat cgaagctttc accagactac catacctgtg tgaaggcgac      900

atgtataatg actactacgt tctggatgac gctgtctttg ttctcaaacc agtataa         957


<210>  96
<211>  1368
<212>  DNA
<213>  Homo sapiens

<400>  96
atgggatggg gagggggtgg aggctgcacc ccgcgcccac ccatccacca gcagccgccg       60

gagcgccgcg tggtcaccgt tgtctttctc ggcctcctgc tggacctcct ggccttcacg      120

ctgctgctgc ccctgctgcc cgggctgttg gagagccacg gccgtgccca cgaccccctc      180

tatggctcct ggcagggcgg ggtggactgg tttgccaccg ccatcgggat gccagtggag      240

aagaggtaca acagtgtcct gttcggaggt ctcattggct cggcattctc tgtcctgcag      300

tttctgtgtg cgccactcac tggggccacc tctgactgct tggggaggcg cccggtgatg      360

ctgctgtgcc tgatgggtgt ggccacctca tatgcagtct gggccacctc tcggagcttt      420

gcggccttcc tggcctccag gctgattggg ggcatcagca aagggaacgt cagcctctcc      480

acggccatcg ttgctgacct gggctcgcct ctggcccgca gtcaaggcat ggcggtcatt      540

ggggtggcct tctcactggg cttcaccctg ggccctatgc tcggagcctc cctgcccctg      600

gaaatggcac cctggtttgc cctgctcttc gcagcctccg acctgctgtt catcttctgc      660

ttcctgccag agacgctgcc cctggagaaa cgggcgccct ctatcgccct ggggttccgt      720

gatgcggctg atctgctcag ccccctggcc ctgctgcgct tctcggctgt cgctcgtggc      780

caggacccac cctctggaga caggctcagc agcctgcgcc gcctgggcct agtctacttc      840

ctctacctct tcctgttctc gggcctggag tacacgctga gcttcctcac acaccagcgc      900

ttccagttca gtagcctaca gcaggggaag atgtttttcc tcatcggcct caccatggcc      960

accatccagg gtgcctatgc ccggcggatc caccctggcg gggaagttgc tgccgtgaag     1020

cgggccctcc tgctgctggt gcccgccttc ctcctcatcg gctggggacg ttctctgccc     1080

gtgctgggcc tggggctgct gctctactcc tttgccgccg ccgttgtggt gccctgcctg     1140

tcctccgtgg tcgctggcta tggctcacca gggcagaagg gcacggtcat gggtacactg     1200

cgcagcctag gtgctctggc cagggccgcg gggcccctgg tggccgcttc agtgtactgg     1260

ctggccgggg cccaggcctg cttcaccacg tggtccgggc tctttttgct ccccttcttc     1320

ctcctgcaga agctgagtta cccggcacag acgctcaagg ctgagtag                  1368


<210>  97
<211>  3204
<212>  DNA
<213>  Homo sapiens

<400>  97
atggcttcac ctacctccac caacccagcg catgcccact ttgagagctt cctgcaggcc       60

cagctgtgcc aggacgtgct gagcagcttc caggagctgt gtggggccct ggggctggaa      120

cccggtgggg ggctgcccca gtaccacaag atcaaggacc agctcaacta ctggagcgcc      180

aagtcactgt ggaccaagct ggacaagcga gcaggccagc ctgtctacca gcagggccgg      240

gcctgcacca gcaccaagtg cctggtggtg ggtgctggac cttgcgggct gcgggtcgct      300

gtggagctgg cgctgctggg ggcccgagtg gtgctggtgg aaaagcgcac caagttctct      360

cgccacaacg tgctccacct ctggcccttc accatccacg acctgcgggc actcggtgct      420

aagaagttct acgggcgctt ctgcaccggc accctggacc acatcagcat caggcagctc      480

cagctgcttc tgctgaaggt agcattgctg ctgggggtgg aaattcactg gggtgtcact      540

ttcactggcc tccagccccc tcctaggaag gggagtggct ggcgtgccca gctccaaccc      600

aacccccctg cccagctggc caactatgaa tttgacgtcc ttatctcggc tgcaggaggt      660

aaattcgtcc ctgaaggctt caaagttcga gaaatgcgag gcaaactggc cattggcatc      720

acagccaact ttgtgaatgg acgcaccgtg gaggagacac aggtgccgga gatcagtggt      780

gtagccagga tctacaacca gagcttcttc cagagccttc tcaaagccac aggcattgat      840

ctggagaaca ttgtgtacta caaggacgac acccactact ttgtgatgac agccaagaag      900

cagtgcctgc tgcggctggg ggtgctgcgc caggactggc cagacaccaa tcggctgctg      960

ggcagtgcca atgtggtgcc cgaggctctg cagcgcttta cccgggcagc tgctgacttt     1020

gccacccatg gcaagctcgg gaaactagag tttgcccagg atgcccatgg gcagcctgat     1080

gtctctgcct ttgacttcac gagcatgatg cgggcagaga gttctgctcg tgtgcaagag     1140

aagcatggcg cccgcctgct gctgggactg gtgggggact gcctggtgga gcccttctgg     1200

cccctgggca ctggagtggc acggggcttc ctggcagcct ttgatgcagc ctggatggtg     1260

aagcggtggg cagagggcgc tgagtcccta gaggtgttgg ctgagcgtga gagcctgtac     1320

cagcttctgt cacagacatc cccagaaaac atgcatcgca atgtggccca gtatgggctg     1380

gacccagcca cccgctaccc caacctgaac ctccgggcag tgacccccaa tcaggtacga     1440

gacctgtatg atgtgctagc caaggagcct gtgcagagga acaacgacaa gacagataca     1500

gggatgccag ccaccgggtc ggcaggcacc caggaggagc tgctacgctg gtgccaggag     1560

cagacagctg ggtacccggg agtccacgtc tccgatttgt cttcctcctg ggctgatggg     1620

ctagctctgt gtgccctggt gtaccggctg cagcctggcc tgctggaacc ctcagagctg     1680

caggggctgg gagctctgga agcaactgct tgggcactaa aggtggcaga gaatgagctg     1740

ggcatcacac cggtggtgtc tgcacaggcc gtggtagcag ggagtgaccc actgggcctc     1800

attgcctacc tcagccactt ccacagtgcc ttcaagagca tggcccacag cccaggccct     1860

gtcagccagg cctccccagg gacctccagt gctgtattat tccttagtaa acttcagagg     1920

accctgcagc gatcccgggc caaggaaaat gcagaggatg ctggtggcaa gaagctgcgc     1980

ttggagatgg aggccgagac cccaagtact gaggtgccac ctgacccaga gcctggtgta     2040

cccctgacac ccccatccca acaccaggag gccggtgctg gggacctgtg tgcactttgt     2100

ggggaacacc tctatgtcct ggaacgcctc tgtgtcaacg gccatttctt ccaccggagc     2160

tgcttccgct gccatacctg tgaggccaca ctgtggccag gtggctacga gcagcaccca     2220

ggagatggac atttctactg cctccagcac ctgccccaga cagaccacaa agcggaaggc     2280

agcgatagag gccctgagag tccggagctc cccacaccaa gtgagaatag catgccacca     2340

ggcctctcaa ctcccacagc ctcgcaggag ggggccggtc ctgttccaga tcccagccag     2400

cccacccgtc ggcagatccg cctctccagc ccggagcgcc agcggttgtc ctcccttaac     2460

cttacccctg acccggaaat ggagcctcca cccaagcctc cccgcagctg ctccgccttg     2520

gcccgccacg ccctggagag cagctttgtg ggctggggcc tgccagtcca gagccctcaa     2580

gctcttgtgg ccatggagaa ggaggaaaaa gagagtccct tctccagtga agaggaagaa     2640

gaagatgtgc ctttggactc agatgtggaa caggccctgc agacctttgc caagacctca     2700

ggcaccatga ataactaccc aacatggcgt cggactctgc tgcgccgtgc gaaggaggag     2760

gagatgaaga ggttctgcaa ggcccagacc atccaacggc gactaaatga gattgaggct     2820

gccttgaggg agctagaggc cgagggcgtg aagctggagc tggccttgag gcgccagagc     2880

agttccccag aacagcaaaa gaaactatgg gtaggacagc tgctacagct cgttgacaag     2940

aaaaacagcc tggtggctga ggaggccgag ctcatgatca cggtgcagga attgaatctg     3000

gaggagaaac agtggcagct ggaccaggag ctacgaggct acatgaaccg ggaagaaaac     3060

ctaaagacag ctgctgatcg gcaggctgag gaccaggtcc tgaggaagct ggtggatttg     3120

gtcaaccaga gagatgccct catccgcttc caggaggagc gcaggctcag cgagctggcc     3180

ttggggacag gggcccaggg ctag                                            3204


<210>  98
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  98
atgttctccc tgaagacgct tccatttctg ctcttactcc atgtgcagat ttccaaggcc       60

tttcctgtat cttctaaaga gaaaaataca aaaactgttc aggactacct ggaaaagttc      120

taccaattac caagcaacca gtatcagtct acaaggaaga atggcactaa tgtgatcgtt      180

gaaaagctta aagaaatgca gcgatttttt gggttgaatg tgacggggaa gccaaatgag      240

gaaactctgg acatgatgaa aaagcctcgc tgtggagtgc ctgacagtgg tggttttatg      300

ttaaccccag gaaaccccaa gtgggaacgc actaacttga cctacaggat tcgaaactat      360

accccacagc tgtcagaggc tgaggtagaa agagctatca aggatgcctt tgaactctgg      420

agtgttgcat cacctctcat cttcaccagg atctcacagg gagaggcaga tatcaacatt      480

gctttttacc aaagagatca cggtgacaat tctccatttg atggacccaa tggaatcctt      540

gctcatgcct ttcagccagg ccaaggtatt ggaggagatg ctcattttga tgccgaagaa      600

acatggacca acacctccgc aaattacaac ttgtttcttg ttgctgctca tgaatttggc      660

cattctttgg ggctcgctca ctcctctgac cctggtgcct tgatgtatcc caactatgct      720

ttcagggaaa ccagcaacta ctcactccct caagatgaca tcgatggcat tcaggccatc      780

tatggacttt caagcaaccc tatccaacct actggaccaa gcacacccaa accctgtgac      840

cccagtttga catttgatgc tatcaccaca ctccgtggag aaatactttt ctttaaagac      900

aggtacttct ggagaaggca tcctcagcta caaagagtcg aaatgaattt tatttctcta      960

ttctggccat cccttccaac tggtatacag gctgcttatg aagattttga cagagacctc     1020

attttcctat ttaaaggcaa ccaatactgg gctctgagtg gctatgatat tctgcaaggt     1080

tatcccaagg atatatcaaa ctatggcttc cccagcagcg tccaagcaat tgacgcagct     1140

gttttctaca gaagtaaaac atacttcttt gtaaatgacc aattctggag atatgataac     1200

caaagacaat tcatggagcc aggttatccc aaaagcatat caggtgcctt tccaggaata     1260

gagagtaaag ttgatgcagt tttccagcaa gaacatttct tccatgtctt cagtggacca     1320

agatattacg catttgatct tattgctcag agagttacca gagttgcaag aggcaataaa     1380

tggcttaact gtagatatgg ctga                                            1404


<210>  99
<211>  1749
<212>  DNA
<213>  Homo sapiens

<400>  99
atgagcatag agacgctact ggaggcggcc cgcttcctgg aatggcaagc gcagcaacaa       60

cagagagcac gtgaggagca ggagcggctt cgcttggagc aggagcgaga gcaggaacag      120

aagaaggcca atagcctggc caggctggca catacccttc ctgtggagga accccgcatg      180

gaggcgccac ccctgcctct gtctccaccg gctcccccgc cggcaccccc accaccactt      240

gccacccctg ccccactgac tgtcatccct atccctgtgg tgaccaactc ccctcagcct      300

ctacccccac ccccaccctt gcccgcggca gcccagcctc tgcccctggc gcctcgtcag      360

ccggccctgg ttggcgcccc cggactcagc attaaggagc ctgcccccct gcccagcagg      420

ccgcaggtgc ccacccctgc tcccctactg ccggactcga aggccaccat tccacccaat      480

ggcagcccca agcctttgca gcccctcccc acgcctgtcc tgaccatagc gccacaccct      540

ggagtccagc ctcagctggc cccccagcag ccgcccccac ccacgctggg gaccctgaag      600

ttggcaccag ctgaagaagt caaatccagt gaacagaaga agaggcccgg ggggatcgga      660

accagagaag tccacaacaa attggagaag aacaggaggg cccatctgaa agagtgcttt      720

gagaccctga agcggaacat ccccaacgtg gatgacaaga agacgtccaa tctgagcgtg      780

ctgcggacgg cgctgcggta catccagtcc ctgaagagga aggagaagga atatgagcat      840

gaaatggagc ggctggcacg tgagaagatt gccacgcagc agcggctggc agagctcaag      900

cacgagctga gccagtggat ggacgtactg gagattgacc gcgtgctgcg gcagacgggc      960

cagcccgagg atgaccaggc ctccacctcc accgcctctg agggtgagga caacatagac     1020

gaggatatgg aggaggaccg ggcgggcctg ggcccaccta agctgagcca tcgtccccag     1080

ccggagctgc tgaagtccac cctgccaccc cccagcacca cccctgcgcc tctgcctcca     1140

cacccacacc ctcaccccca ctccgtggcc ctacctcctg cccacctccc cgtgcagcag     1200

cagcagccac agcagaagac ccctctgcca gcccctcctc ccccaccggc tgcccctgcc     1260

cagacactgg tgccagctcc agcccatctg gtggcgacgg ctgggggtgg ctccacggtc     1320

atcgcccaca cagccaccac tcacgcttca gtcatccaga ctgtgaacca cgttctgcag     1380

gggccaggcg gcaagcacat cgcccacatc gccccctcgg cccccagccc tgcggtgcaa     1440

ctggcgcctg ccacaccccc cattgggcac atcactgtgc accctgccac cctcaaccat     1500

gtggcccacc tgggctccca gctgcccttg tacccgcagc ccgtggcagt gagccacatc     1560

gcccacaccc tctcgcacca gcaagtcaac ggcacggccg gcctggggcc cccggctact     1620

gtcatggcaa agccggccgt gggggctcag gtggtgcacc acccccagct ggtgggccag     1680

accgtgctca accctgtgac catggtcacc atgccctcct tcccagtcag cacactcaag     1740

ctggcttga                                                             1749


<210>  100
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  100
atggcggcgt ctgtattaaa caccgtgctg aggcggcttc ctatgctatc tctcttccga       60

ggttctcaca gagttcaggt tcccctccag actctttgca ccaaagctcc ctctgaggaa      120

gattctttgt cctcagttcc catttctcct tataaggatg agccctggaa atatctggaa      180

tcagaagaat accaggagcg atatggttct cgccccgtct gggctgacta ccgccgcaac      240

cacaagggtg gtgtaccccc acagcggact cggaagacat gtattcgtcg gaataaagtt      300

gttgggaatc cctgccccat ctgtcgagat cacaagttgc atgttgactt taggaacgtg      360

aagctcttgg agcaatttgt ctgcgcccac acgggtatca tcttctatgc tccatacaca      420

ggagtctgtg tgaagcagca caagcggttg acccaggcca tccagaaagc cagggatcat      480

ggtctcctca tttaccacat cccccaggtt gaaccacggg accttgactt cagtacctct      540

catggggctg tgagtgctac tccgccagcc cccaccctgg tctcaggtga cccctggtac      600

ccatggtaca actggaaaca gccaccggag agagaactgt ctcgccttcg ccggctttac      660

cagggtcatc tccaagaaga gagtggcccc ccacctgagt caatgcccaa gatgccccct      720

agaacaccag cggaagcctc ctccactggg cagacaggcc ctcagagtgc tctgtag         777


<210>  101
<211>  2253
<212>  DNA
<213>  Homo sapiens

<400>  101
atgttaagag ctaagaatca gcttttttta ctttcacctc attacctgag gcaggtaaaa       60

gaatcatcag gctccaggct catacagcaa cgacttctac accagcaaca gccccttcac      120

ccagaatggg ctgccctggc taaaaagcag ctgaaaggca aaaacccaga agacctaata      180

tggcacaccc cggaagggat ctctataaaa cccttgtatt ccaagagaga tactatggac      240

ttacctgaag aacttccagg agtgaagcca ttcacacgtg gaccatatcc taccatgtat      300

acctttaggc cctggaccat ccgccagtat gctggtttta gtactgtgga agaaagcaat      360

aagttctata aggacaacat taaggctggt cagcagggat tatcagttgc ctttgatctg      420

gcgacacatc gtggctatga ttcagacaac cctcgagttc gtggtgatgt tggaatggct      480

ggagttgcta ttgacactgt ggaagatacc aaaattcttt ttgatggaat tcctttagaa      540

aaaatgtcag tttccatgac tatgaatgga gcagttattc cagttcttgc aaattttata      600

gtaactggag aagaacaagg tgtacctaaa gagaagctta ctggtaccat ccaaaatgat      660

atactaaagg aatttatggt tcgaaataca tacatttttc ctccagaacc atccatgaaa      720

attattgctg acatatttga atatacagca aagcacatgc caaaatttaa ttcaatttca      780

attagtggat accatatgca ggaagcaggg gctgatgcca ttctggagct ggcctatact      840

ttagcagatg gattggagta ctctagaact ggactccagg ctggcctgac aattgatgaa      900

tttgcaccaa ggttgtcttt cttctgggga attggaatga atttctatat ggaaatagca      960

aagatgagag ctggtagaag actctgggct cacttaatag agaaaatgtt tcagcctaaa     1020

aactcaaaat ctcttcttct aagagcacac tgtcagacat ctggatggtc acttactgag     1080

caggatccct acaataatat tgtccgtact gcaatagaag caatggcagc agtatttgga     1140

gggactcagt ctttgcacac aaattctttt gatgaagctt tgggtttgcc aactgtgaaa     1200

agtgctcgaa ttgccaggaa cacacaaatc atcattcaag aagaatctgg gattcccaaa     1260

gtggctgatc cttggggagg ttcttacatg atggaatgtc tcacaaatga tgtttatgat     1320

gctgctttaa agctcattaa tgaaattgaa gaaatgggtg gaatggccaa agctgtagct     1380

gagggaatac ctaaacttcg aattgaagaa tgtgctgccc gaagacaagc tagaatagat     1440

tctggttctg aagtaattgt tggagtaaat aagtaccagt tggaaaaaga agacgctgta     1500

gaagttctgg caattgataa tacttcagtg cgaaacaggc agattgaaaa acttaagaag     1560

atcaaatcca gcagggatca agctttggct gaacgttgtc ttgctgcact aaccgaatgt     1620

gctgctagcg gagatggaaa tatcctggct cttgcagtgg atgcatctcg ggcaagatgt     1680

acagtgggag aaatcacaga tgccctgaaa aaggtatttg gtgaacataa agcgaatgat     1740

cgaatggtga gtggagcata tcgccaggaa tttggagaaa gtaaagagat aacatctgct     1800

atcaagaggg ttcataaatt catggaacgt gaaggtcgca gacctcgtct tcttgtagca     1860

aaaatgggac aagatggcca tgacagagga gcaaaagtta ttgctacagg atttgctgat     1920

cttggttttg atgtggacat aggccctctt ttccagactc ctcgtgaagt ggcccagcag     1980

gctgtggatg cggatgtgca tgctgtgggc ataagcaccc tcgctgctgg tcataaaacc     2040

ctagttcctg aactcatcaa agaacttaac tcccttggac ggccagatat tcttgtcatg     2100

tgtggagggg tgataccacc tcaggattat gaatttctgt ttgaagttgg tgtttccaat     2160

gtatttggtc ctgggactcg aattccaaag gctgccgttc aggtgcttga tgatattgag     2220

aagtgtttgg aaaagaagca gcaatctgta taa                                  2253


<210>  102
<211>  1989
<212>  DNA
<213>  Homo sapiens

<400>  102
atggttgttt ccgaagtgga catcgcaaaa gctgatccag ctgctgcatc ccaccctcta       60

ttactgaatg gagatgctac tgtggcccag aaaaatccag gctcggtggc tgagaacaac      120

ctgtgcagcc agtatgagga gaaggtgcgc ccctgcatcg acctcattga ctccctgcgg      180

gctctaggtg tggagcagga cctggccctg ccagccatcg ccgtcatcgg ggaccagagc      240

tcgggcaaga gctccgtgtt ggaggcactg tcaggagttg cccttcccag aggcagcggg      300

atcgtgacca gatgcccgct ggtgctgaaa ctgaagaaac ttgtgaacga agataagtgg      360

agaggcaagg tcagttacca ggactacgag attgagattt cggatgcttc agaggtagaa      420

aaggaaatta ataaagccca gaatgccatc gccggggaag gaatgggaat cagtcatgag      480

ctaatcaccc tggagatcag ctcccgagat gtcccggatc tgactctaat agaccttcct      540

ggcataacca gagtggctgt gggcaatcag cctgctgaca ttgggtataa gatcaagaca      600

ctcatcaaga agtacatcca gaggcaggag acaatcagcc tggtggtggt ccccagtaat      660

gtggacatcg ccaccacaga ggctctcagc atggcccagg aggtggaccc cgagggagac      720

aggaccatcg gaatcttgac gaagcctgat ctggtggaca aaggaactga agacaaggtt      780

gtggacgtgg tgcggaacct cgtgttccac ctgaagaagg gttacatgat tgtcaagtgc      840

cggggccagc aggagatcca ggaccagctg agcctgtccg aagccctgca gagagagaag      900

atcttctttg agaaccaccc atatttcagg gatctgctgg aggaaggaaa ggccacggtt      960

ccctgcctgg cagaaaaact taccagcgag ctcatcacac atatctgtaa atctctgccc     1020

ctgttagaaa atcaaatcaa ggagactcac cagagaataa cagaggagct acaaaagtat     1080

ggtgtcgaca taccggaaga cgaaaatgaa aaaatgttct tcctgataga taaagttaat     1140

gcctttaatc aggacatcac tgctctcatg caaggagagg aaactgtagg ggaggaagac     1200

attcggctgt ttaccagact ccgacacgag ttccacaaat ggagtacaat aattgaaaac     1260

aattttcaag aaggccataa aattttgagt agaaaaatcc agaaatttga aaatcagtat     1320

cgtggtagag agctgccagg ctttgtgaat tacaggacat ttgagacaat cgtgaaacag     1380

caaatcaagg cactggaaga gccggctgtg gatatgctac acaccgtgac ggatatggtc     1440

cggcttgctt tcacagatgt ttcgataaaa aattttgaag agttttttaa cctccacaga     1500

accgccaagt ccaaaattga agacattaga gcagaacaag agagagaagg tgagaagctg     1560

atccgcctcc acttccagat ggaacagatt gtctactgcc aggaccaggt atacaggggt     1620

gcattgcaga aggtcagaga gaaggagctg gaagaagaaa agaagaagaa atcctgggat     1680

tttggggctt tccagtccag ctcggcaaca gactcttcca tggaggagat ctttcagcac     1740

ctgatggcct atcaccagga ggccagcaag cgcatctcca gccacatccc tttgatcatc     1800

cagttcttca tgctccagac gtacggccag cagcttcaga aggccatgct gcagctcctg     1860

caggacaagg acacctacag ctggctcctg aaggagcgga gcgacaccag cgacaagcgg     1920

aagttcctga aggagcggct tgcacggctg acgcaggctc ggcgccggct tgcccagttc     1980

cccggttaa                                                             1989


<210>  103
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  103
atgtccagca agcgggccaa agccaagacc accaagaagc ggccacagcg ggccacatcc       60

aatgtcttcg caatgtttga ccagtcccag atccaggagt ttaaggaggc tttcaacatg      120

attgaccaga accgtgatgg cttcattgac aaggaggacc tgcacgacat gctggcctcg      180

ctggggaaga accccacaga cgaatacctg gagggcatga tgagcgaggc cccggggccc      240

atcaacttca ccatgttcct caccatgttt ggggagaagc tgaacggcac ggaccccgag      300

gatgtgattc gcaacgcctt tgcctgcttc gacgaggaag cctcaggttt catccatgag      360

gaccacctcc gggagctgct caccaccatg ggtgaccgct tcacagatga ggaagtggac      420

gagatgtacc gggaggcacc cattgataag aaaggcaact tcaactacgt ggagttcacc      480

cgcatcctca aacatggcgc caaggataaa gacgactag                             519


<210>  104
<211>  4398
<212>  DNA
<213>  Homo sapiens

<400>  104
atgtcccttg tgactgtccc cttctaccag aagagacata ggcacttcga ccagtcctac       60

cgtaatattc aaacacggta cctgctggac gaatatgcgt caaaaaagcg agcttccacc      120

caggcatctt cccagaagtc cttgagtcag cggtcgtctt cacagagagc ctccagccag      180

acgtccctgg gaggaaccat ctgcagggtc tgtgcgaagc gagtgagcac gcaggaagat      240

gaggagcagg agaacagaag caggtaccag tccctggtgg ccgcctatgg tgaggccaag      300

cgacagcgct tcctcagcga gctggcccac ttggaggagg atgtccacct ggcacgctcc      360

caggcccgcg acaagctgga caaatacgcc attcagcaga tgatggagga caagctggcc      420

tgggagagac acacatttga agagcggata agcagggctc ctgagatcct ggtgcggctg      480

cgatcccaca ccgtctggga gaggatgtct gtgaaactct gcttcaccgt gcaaggattt      540

cccacgcccg tggtgcagtg gtacaaagat ggcagtctga tttgccaggc ggctgaaccg      600

ggaaagtaca ggattgagag caactatggc gtacacacac tggagatcaa cagggcagac      660

tttgacgaca ctgcgacata ctcagcagtg gccaccaatg cccacggaca agtgtccacc      720

aacgcggcgg tggtggtgag aaggttccgg ggagacgagg aaccattccg ttcggtggga      780

ctcccgattg gattgcccct gtcatcgatg attccgtaca cgcacttcga cgtccagttt      840

ttggagaagt ttggggtcac cttcaggagg gaaggcgaga cggtcactct caagtgcacc      900

atgctggtga cgccggacct gaagcgggtg cagccgcgcg ccgagtggta ccgcgatgac      960

gtgctgttga aagagtccaa gtggacgaag atgttctttg gagaaggcca ggcctccctg     1020

tccttcagcc acctgcacaa ggacgacgag ggcctgtaca ccctgcgcat cgtgtctcgg     1080

ggcggcgtca gcgaccacag cgccttcctg tttgtcagag atgctgaccc gctggtcaca     1140

ggggcccccg gtgcacccat ggacttgcag tgccacgacg ccaaccggga ctacgtcatc     1200

gtgacctgga agccgcccaa caccaccact gagagccccg tcatgggcta ttttgtggac     1260

cgatgtgaag taggaacgaa taattgggtg cagtgcaatg atgcaccggt gaaaatctgc     1320

aaatacccgg tcacagggct ttttgaagga aggtcttaca tattccgagt gagggcagtg     1380

aacagtgcgg gcatcagccg accctccagg gtctctgatg cggtggctgc acttgacccc     1440

ttggacctca gaaggttaca agccgttcat ttggagggag agaaggagat tgccatttat     1500

caggatgacc ttgaaggtga cgcccaggtt ccagggcctc ccaccggtgt gcacgcttcc     1560

gagatcagca gaaactatgt cgtcctcagc tgggagccac ccactccccg tggcaaggac     1620

ccgctcatgt acttcattga gaagtcggtg gtggggagcg gcagctggca gagagtcaac     1680

gcccagacgg ctgtgagatc cccgagatat gccgtgtttg acctcatgga agggaagtct     1740

tatgtgttcc gagtgctgtc agcaaaccgg catggcctga gcgaaccttc ggagataacg     1800

tcccccattc aggcccagga tgtgaccgtt gtcccttctg ctccgggtcg ggttcttgct     1860

tcccgaaaca ccaagacgtc ggtggtggtg cagtgggacc gacctaagca tgaggaggac     1920

ctgctgggct actacgtgga ctgctgtgtg gccggaacca acctctggga gccctgcaac     1980

cacaagccca ttggatacaa caggttcgtg gtgcacggct taaccacggg agagcagtac     2040

atcttccgag tcaaggcggt caatgctgtg gggatgagtg aaaattccca ggaatcagac     2100

gtcataaaag tgcaggccgc actcaccgtc ccgtcccatc cttatgggat tacgctcctc     2160

aactgtgacg gccactccat gaccctcggc tggaaggtcc cgaaattcag tggtggctcg     2220

cccatcctgg gctactacct ggacaagcgt gaagttcacc ataaaaactg gcacgaggtc     2280

aattcctcac ccagcaaacc gacaatccta acggtggacg gcttgacgga aggctcactc     2340

tacgagttca aaatcgccgc cgtcaacctg gccggcatcg gggagccctc agatcccagt     2400

gagcacttca agtgtgaggc ctggaccatg ccggagcccg gtcctgccta cgacttgacg     2460

ttctgtgagg tcagggacac gtccttggtc atgctgtgga aggcccctgt gtactccggc     2520

agcagccctg tttctggata tttcgtggac ttcagggagg aggatgctgg agagtggatc     2580

actgtaaatc agacgacaac agccaaccgt tatttaaagg tctctgacct gcagcaaggt     2640

aagacctatg tcttcagggt ccgggcagtc aatgcaaatg gcgtggggaa gccctcagac     2700

acgtcggagc ctgtgctggt agaggcgaga ccaggcacca aggaaatcag tgctggtgtc     2760

gatgaacaag gcaacatcta tctgggcttc gactgccagg aaatgacaga cgcgtctcag     2820

ttcacctggt gtaaatccta cgaggagatt tcagatgatg agaggtttaa aatcgaaacc     2880

gtgggggatc actccaagct gtacttaaag aatccggata aggaggattt agggacttac     2940

tccgtgtctg taagtgatac agacggagtg tcctccagtt ttgttctgga cccagaagag     3000

ctcgagcgtt tgatggcatt gagcaatgaa ataaagaacc ccacaattcc tctgaaatcg     3060

gaattagctt atgagatttt tgataagggg cgggttcgct tctggctcca ggctgagcac     3120

ttatcaccag atgccagcta ccgatttatt attaacgaca gagaagtctc tgacagcgag     3180

atacacagaa ttaaatgtga caaagctact ggcattattg agatggtgat ggatcgattt     3240

agtattgaaa atgaggggac ctacactgtg cagattcatg atgggaaagc caaaagtcag     3300

tcttctctag ttcttattgg agatgcattc aagactgtgc tggaagaggc tgagtttcaa     3360

aggaaagaat ttctcaggaa acaaggccct cattttgctg agtacttgca ctgggatgtc     3420

acggaagaat gtgaagttcg acttgtttgc aaggttgcaa acaccaagaa agaaaccgtt     3480

ttcaaatggc tcaaggatga tgttctgtat gaaacggaga cactgcctaa cctggagagg     3540

ggaatctgtg agctcctcat cccaaagttg tcaaagaagg accacggtga atacaaggca     3600

accttgaaag atgacagagg ccaagatgtg tccatccttg aaatagctgg caaagtgtat     3660

gatgatatga ttttggcaat gagtagagtc tgtgggaaat ctgcttcgcc actgaaggta     3720

ctctgcaccc cagaaggaat acgacttcag tgtttcatga agtattttac agacgaaatg     3780

aaagtgaact ggtgtcacaa agatgctaag atctcatcca gtgagcatat gagaatcggg     3840

gggagtgaag agatggcttg gctgcagata tgtgagccga ctgagaagga taaaggaaaa     3900

tacacttttg agattttcga tggcaaagac aaccatcaac gctcccttga cctgtccgga     3960

caagcttttg atgaagcatt tgcagaattc cagcaattca aagctgctgc ttttgcagag     4020

aagaatcgtg gcaggttgat cggcggcttg cctgacgtgg tgaccatcat ggaagggaag     4080

accttgaatc tgacctgcac ggtgtttgga aaccctgacc ccgaagtgat ttggttcaag     4140

aacgaccagg acatccagct cagcgagcac ttctcggtga aggtggagca ggccaagtac     4200

gtcagcatga ccatcaaagg cgtgacctcc gaggactcgg gcaagtacag catcaacatc     4260

aagaataagt atggcgggga gaagatcgac gtgacagtga gcgtgtacaa acacggggag     4320

aagatcccgg acatggcccc gccccagcaa gccaagccca agctcatccc cgcgtctgcc     4380

tcagcggcag gccagtga                                                   4398


<210>  105
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  105
atgcgcacgc gcacagggag tcagctggct gcgcgggagg tcacgggaag tggggcggtg       60

cccagacagc tggagggaag gaggtgtcag gcggggagag acgcaaacgg cgggaccagc      120

agcgacggta gcagcagcat ggccgcgatc tatgggggtg tagagggggg aggcacacga      180

tccgaggtcc ttttagtctc agaggatggg aagatcctgg cagaagcaga tggactgagc      240

acaaaccact ggctgatcgg gacagacaag tgtgtggaga ggatcaatga gatggtgaac      300

agggccaaac ggaaagcagg ggtggatcct ctggtaccgc tgcgaagctt gggcctatct      360

ctgagcggtg gggaccagga ggacgcgggg aggatcctga tcgaggagct gagggaccga      420

tttccctacc tgagtgaaag ctacttaatc accaccgatg ccgccggctc catcgccaca      480

gctacaccgg atggtggagt tgtgctcata tctggaacag gctccaactg caggctcatc      540

aaccctgatg gctccgagag tggctgcggc ggctggggcc atatgatggg tgatgagggt      600

tcagcctact ggatcgcaca ccaagcagtg aaaatagtgt ttgactccat tgacaaccta      660

gaggcggctc ctcatgatat cggctacgtc aaacaggcca tgttccacta tttccaggtg      720

ccagatcggc tagggatact cactcacctg tatagggact ttgataaatg caggtttgct      780

gggttttgcc ggaaaattgc agaaggtgct cagcagggag accccctttc ccgctatatc      840

ttcaggaagg ctggggagat gctgggcaga cacatcgtag cagtgttgcc cgagattgac      900

ccggtcttgt tccagggcaa gattggactc cccatcctgt gcgtgggctc tgtgtggaag      960

agctgggagc tgctgaagga aggttttctt ctggcgctga cccagggcag agagatccag     1020

gctcagaact tcttctccag cttcaccctg atgaagctga ggcactcctc cgctctgggt     1080

ggggccagcc taggggccag gcacatcggg cacctcctcc ccatggacta tagcgccaat     1140

gccattgcct tctattccta caccttttcc tag                                  1173


<210>  106
<211>  924
<212>  DNA
<213>  Homo sapiens

<400>  106
atggaagctg ataaagatga cacacaacaa attcttaagg agcattcgcc agatgaattt       60

ataaaagatg aacaaaataa gggactaatt gatgaaatta caaagaaaaa tattcaacta      120

aagaaggaga tccaaaagct tgaaacggag ttacaagagg ctaccaaaga attccagatt      180

aaagaggata ttcctgaaac aaagatgaaa ttcttatcag ttgaaactcc tgagaatgac      240

agccagttgt caaatatctc ctgttcgttt caagtgagct cgaaagttcc ttatgagata      300

caaaaaggac aagcacttat cacctttgaa aaagaagaag ttgctcaaaa tgtggtaagc      360

atgagtaaac atcatgtaca gataaaagat gtaaatctgg aggttacggc caagccagtt      420

ccattaaatt caggagtcag attccaggtt tatgtagaag tttctaaaat gaaaatcaat      480

gttactgaaa ttcctgacac attgcgtgaa gatcaaatga gagacaaact agagctgagc      540

ttttcaaagt cccgaaatgg aggcggagag gtggaccgcg tggactatga cagacagtcc      600

gggagtgcag tcatcacgtt tgtggagatt ggagtggctg acaagatttt gaaaaagaaa      660

gaataccctc tttatataaa tcaaacctgc catagagtta ctgtttctcc atacacagaa      720

atacacttga aaaagtatca gatattttca ggaacatcta agaggacagt gcttctgaca      780

ggaatggaag gcattcaaat ggatgaagaa attgtggagg atttaattaa cattcacttt      840

caacgggcaa agaatggagg tggagaagta gatgtggtca agtgttctct aggtcaacct      900

cacatagcat actttgaaga atag                                             924


<210>  107
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  107
atggccattt gtcaattctt ccttcaaggc cggtgccgct ttggagatcg gtgctggaac       60

gaacatcccg gtgctagggg tgcaggagga ggacggcagc aaccgcagca gcagccttca      120

ggtaataata gacgtggatg gaatacaact agccagagat attccaatgt catccagcca      180

tccagtttct ccaaatccac accatggggg ggcagcagag atcaagaaaa gccatatttc      240

agttcttttg attctggagc ttcaactaac aggaaggaag gctttggatt gtctgagaac      300

ccatttgctt cacttagtcc tgatgagcag aaagatgaaa agaaacttct ggaaggaatt      360

gtaaaagata tggaggtttg ggaatcatca gggcagtgga tgttttctgt ttattcacca      420

gtgaaaaaga aacctaatat ttcaggtttt acagacattt caccagagga attgaggctt      480

gaataccata acttcttaac cagcaataac ttacagagtt atctaaattc tgtccaacgt      540

ttaataaatc aatggaggaa cagggtaaat gaactgaaaa gtctaaatat atcaactaaa      600

gtagctttgc tctctgatgt aaaggatgga gtaaatcaag cagcacctgc atttggattt      660

ggcagcagtc aagcagcaac atttatgtcg ccaggctttc cagtcaataa cagcagcagt      720

gataatgctc agaactttag ttttaaaaca aactctggat ttgctgctgc ctcttctgga      780

agccctgctg gttttgggag ttccccagca tttggagctg cagcctctac cagttcaggt      840

atctctactt ctgctccagc ttttggattt gggaagcctg aagtcacatc ggctgcatca      900

ttttcattca aaagccctgc agcttccagt tttggatcac ctggattttc aggacttcca      960

gcttccttgg caacaggtcc tgtcagagct ccagtggccc cagcctttgg aggtggcagt     1020

tctgtggctg gttttggtag tccgggctca cattctcaca ctgctttttc taagccatcc     1080

agtgacactt ttggaaatag cagcatatcc acttctctgt cagcctcaag cagcatcatt     1140

gcaacagata atgtgttatt cacacccaga gataaactaa cagtagaaga actggaacaa     1200

tttcaatcca agaaatttac tctgggaaaa attccattaa agcctccacc tctggaactt     1260

ctaaatgttt aa                                                         1272


<210>  108
<211>  1107
<212>  DNA
<213>  Homo sapiens

<400>  108
atgcagcctg gatccagccg gtgtgaagag gagacccctt ccctcttgtg gggtttggat       60

cctgtgtttc tagcctttgc aaaactctac atcagggata tcctggacat gaaggagtcc      120

cgccaggtgc caggtgtatt tttgtacaat ggacatccaa taaaacaggt agatgtcttg      180

ggaactgtca ttggagtgag agaaagagat gctttctaca gttatggagt ggatgacagc      240

actggagtta taaactgcat ctgctggaaa aagttgaata ctgagtctgt atcagctgct      300

ccaagtgcag caagagagct cagcttaacc tcacaactta agaagctaca agagaccatt      360

gagcagaaaa caaagataga gatcggggac acgatccgag tcagaggcag tatccgcaca      420

tacagagaag agcgagagat tcatgccacc acttactata aagtggacga cccagtgtgg      480

aacattcaaa ttgcaaggat gcttgagctg cccactatct acaggaaagt ttatgaccag      540

ccttttcaca gctcagccct agagaaagaa gaggcactaa gcaatccagg cgccctggac      600

ctccccagtc tcacgagttt gctgagtgaa aaagccaaag aattcctcat ggagaacaga      660

gtgcagagct tttaccagca ggagctggaa atggtggagt ctttgctgtc ccttgccaat      720

cagcctgtga ttcacagtgc ctcctccgac caagtgaatt ttaagaagga caccacttcc      780

aaggcaattc atagtatatt taagaatgct atacaactgc tgcaggaaaa aggacttgtt      840

ttccagaaag atgatggttt tgataaccta tactatgtaa ccagagaaga caaagacctg      900

cacagaaaga tccaccggat cattcagcag gactgccaga aaccaaatca catggagaag      960

ggctgtcact tcctgcacat cttggcctgt gctcgcctga gcatccgccc gggcctgagc     1020

gaggctgtgc tgcagcaagt tctggagctc ctggaggacc agagtgacat tgtcagcaca     1080

atggagcact actacacagc gttctga                                         1107


<210>  109
<211>  2211
<212>  DNA
<213>  Homo sapiens

<400>  109
atggcgtcca tcatggaagg gccgctgagc aaatggacta acgtgatgaa gggctggcag       60

taccgttggt tcgtgctgga ctacaatgca ggactgctct cctactacac gtccaaggac      120

aaaatgatga gaggctctcg cagaggatgt gttagactca gaggagctgt gattggtata      180

gacgatgagg acgacagcac cttcacaata actgttgatc agaaaacctt ccatttccag      240

gcccgtgatg ctgatgagcg agagaagtgg atccatgcct tagaagaaac aattcttcga      300

catactctcc agcttcaagg tttggattca ggatttgttc ctagtgtcca agattttgat      360

aagaaactta cagaagctga tgcttaccta caaatcttga ttgaacaatt aaagcttttt      420

gatgacaagc ttcaaaactg caaagaagat gaacagagaa agaaaattga aactctcaaa      480

gagacaacaa atagcatggt agaatcaatt aaacactgca ttgtgttgct gcagattgcc      540

aaagaccaga gtaatgcgga gaagcacgca gatggaatga taagtactat taatcccgta      600

gatgcaatat atcaacctag tcctttggaa cctgtgatca gcacaatgcc ttcccagact      660

gtgttacctc cagaacctgt tcagttgtgt aagtcagagc agcgtccatc ttccctacca      720

gttggacctg tgttggctac cttgggacat catcagactc ctacaccaaa tagtacaggc      780

agtggccatt caccaccgag tagcagtctc acttctccaa gccacgtgaa cttgtctcca      840

aatacagtcc cagagttctc ttactccagc agtgaagatg aattttatga tgctgatgaa      900

ttccatcaaa gtggctcatc cccaaagcgc ttaatagatt cttctggatc tgcctcagtc      960

ctgacacaca gcagctcggg aaatagtcta aaacgcccag ataccacaga atcacttaat     1020

tcttccttgt ccaatggaac aagtgatgct gacctgtttg attcacatga tgacagagat     1080

gatgatgcgg aggcagggtc tgtggaggag cacaagagcg ttatcatgca tctcttgtcg     1140

caggttagac ttggaatgga tcttactaag gtagttcttc caacgtttat tcttgaaaga     1200

agatctcttt tagaaatgta tgcagacttt tttgcacatc cggacctgtt tgtgagcatt     1260

agtgaccaga aggatcccaa ggatcgaatg gttcaggttg tgaaatggta cctctcagcc     1320

tttcatgcgg gaaggaaagg atcagttgcc aaaaagccat acaatcccat tttgggcgag     1380

atttttcagt gtcattggac attaccaaat gatactgaag agaacacaga actagtttca     1440

gaaggaccag ttccctgggt ttccaaaaac agtgtaacat ttgtggctga gcaggtttcc     1500

catcatccac ccatttcagc cttttatgct gagtgtttta acaagaagat acaattcaat     1560

gctcatatct ggaccaaatc aaaattcctt gggatgtcaa ttggggtgca caacataggg     1620

cagggctgtg tctcatgtct agactatgat gaacattaca ttctcacatt ccccaatggc     1680

tatggaaggt ctatcctcac agtgccctgg gtggaattag gaggagaatg caatattaat     1740

tgttccaaaa caggctatag tgcaaatatc atcttccaca ctaaaccctt ctatgggggc     1800

aagaagcaca gaattactgc cgagattttt tctccaaatg acaagaagtc tttttgctca     1860

attgaagggg aatggaatgg tgtgatgtat gcaaaatatg caacagggga aaatacagtc     1920

tttgtagata ccaagaagtt gcctataatc aagaagaaag tgaggaagtt ggaagatcag     1980

aacgagtatg aatcccgcag cctttggaag gatgtcactt tcaacttaaa aatcagagac     2040

attgatgcag caactgaagc aaagcacagg cttgaagaaa gacaaagagc agaagcccga     2100

gaaaggaagg agaaggaaat tcagtgggag acaaggttat ttcatgaaga tggagaatgc     2160

tgggtttatg atgaaccatt actgaaacgt cttggtgctg ccaagcatta g              2211


<210>  110
<211>  1179
<212>  DNA
<213>  Homo sapiens

<400>  110
atgggggtca accagtctgt gggctttcca cctgtcacag gaccccacct cgtaggctgt       60

ggggatgtga tggagggtca gaatctccag gggagcttct ttcgactctt ctacccctgc      120

caaaaggcag aggagaccat ggagcagccc ctgtggattc cccgctatga gtactgcact      180

ggcctggccg agtacctgca gtttaataag cgctgcgggg gcttgctgtt caacctggcg      240

gtgggatctt gtcgcctgcc tgttagctgg aatggcccct ttaagacaaa ggactctgga      300

taccccttga tcatcttctc ccatggccta ggagccttca ggactttgta ttcagccttc      360

tgcatggagc tggcctcacg tggctttgtg gttgctgtgc cagagcacag ggaccggtca      420

gcggcaacca cctatttctg caagcaggcc ccagaagaga accagcccac caatgaatcg      480

ctgcaggagg aatggatccc tttccgtcga gttgaggaag gggagaagga atttcatgtt      540

cggaatcccc aggtgcatca gcgggtaagc gagtgtttac gggtgttgaa gatcctgcaa      600

gaggtcactg ctgggcagac tgtcttcaac atcttgcctg gtggcttgga tctgatgact      660

ttgaagggca acattgacat gagccgtgtg gctgtgatgg gacattcatt tggaggggcc      720

acagctattc tggctttggc caaggagacc caatttcggt gtgcggtggc tctggatgct      780

tggatgtttc ctctggaacg tgacttttac cccaaggccc gaggacctgt gttctttatc      840

aatactgaga aattccagac aatggagagt gtcaatttga tgaagaagat atgtgcccag      900

catgaacagt ctaggatcat aaccgttctt ggttctgttc atcggagtca aactgacttt      960

gcttttgtga ctggcaactt gattggtaaa ttcttctcca ctgaaacccg tgggagcctg     1020

gacccctatg aagggcagga ggttatggta cgggccatgt tggccttcct gcagaagcac     1080

ctcgacctga aagaagacta taatcaatgg aacaacctta ttgaaggcat tggaccgtcg     1140

ctcaccccag gggcccccca ccatctgtcc agcctgtag                            1179


<210>  111
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  111
atggcgtggc gaggctgggc gcagagaggc tggggctgcg gccaggcgtg gggtgcgtcg       60

gtgggcggcc gcagctgcga ggagctcact gcggtcctaa ccccgccgca gctcctcgga      120

cgcaggttta acttctttat tcaacaaaaa tgcggattca gaaaagcacc caggaaggtt      180

gaacctcgaa gatcagaccc agggacaagt ggtgaagcat acaagagaag tgctttgatt      240

cctcctgtgg aagaaacagt cttttatcct tctccctatc ctataaggag tctcataaaa      300

cctttatttt ttactgttgg gtttacaggc tgtgcatttg gatcagctgc tatttggcaa      360

tatgaatcac tgaaatccag ggtccagagt tattttgatg gtataaaagc tgattggttg      420

gatagcataa gaccacaaaa agaaggagac ttcagaaagg agattaacaa gtggtggaat      480

aacctaagtg atggccagcg gactgtgaca ggtattatag ctgcaaatgt ccttgtattc      540

tgtttatgga gagtaccttc tctgcagcgg acaatgatca gatatttcac atcgaatcca      600

gcctcaaagg tcctttgttc tccaatgttg ctgtcaacat tcagtcattt ctccttattt      660

cacatggcag caaatatgta tgttttgtgg agcttctctt ccagcatagt gaacattctg      720

ggtcaagagc agttcatggc agtgtaccta tctgcaggtg ttatttccaa ttttgtcagt      780

tacgtgggta aagttgccac aggaagatat ggaccatcac ttggtgcatc tggtgccatc      840

atgacagtcc tcgcagctgt ctgcactaag atcccagaag ggaggcttgc cattattttc      900

cttccgatgt tcacgttcac agcagggaat gccctgaaag ccattatcgc catggataca      960

gcaggaatga tcctgggatg gaaatttttt gatcatgcgg cacatcttgg gggagctctt     1020

tttggaatat ggtatgttac ttacggtcat gaactgattt ggaagaacag ggagccgcta     1080

gtgaaaatct ggcatgaaat aaggactaat ggccccaaaa aaggaggtgg ctctaagtaa     1140


<210>  112
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  112
atggcggacg aggagcttga ggcgctgagg agacagaggc tggccgagct gcaggccaaa       60

cacggggatc ctggtgatgc ggcccaacag gaagcaaagc acagggaagc agaaatgaga      120

aacagtatct tagcccaagt tctggatcag tcggcccggg ccaggttaag taacttagca      180

cttgtaaagc ctgaaaaaac taaagcagta gagaattacc ttatacagat ggcaagatat      240

ggacaactaa gtgagaaggt atcagaacaa ggtttaatag aaatccttaa aaaagtaagc      300

caacaaacag aaaagacaac aacagtgaaa ttcaacagaa gaaaagtaat ggactctgat      360

gaagatgacg attattga                                                    378


<210>  113
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  113
atgagcctct tcgggcttct cctgctgaca tctgccctgg ccggccagag acaggggact       60

caggcggaat ccaacctgag tagtaaattc cagttttcca gcaacaagga acagaacgga      120

gtacaagatc ctcagcatga gagaattatt actgtgtcta ctaatggaag tattcacagc      180

ccaaggtttc ctcatactta tccaagaaat acggtcttgg tatggagatt agtagcagta      240

gaggaaaatg tatggataca acttacgttt gatgaaagat ttgggcttga agacccagaa      300

gatgacatat gcaagtatga ttttgtagaa gttgaggaac ccagtgatgg aactatatta      360

gggcgctggt gtggttctgg tactgtacca ggaaaacaga tttctaaagg aaatcaaatt      420

aggataagat ttgtatctga tgaatatttt ccttctgaac cagggttctg catccactac      480

aacattgtca tgccacaatt cacagaagct gtgagtcctt cagtgctacc cccttcagct      540

ttgccactgg acctgcttaa taatgctata actgccttta gtaccttgga agaccttatt      600

cgatatcttg aaccagagag atggcagttg gacttagaag atctatatag gccaacttgg      660

caacttcttg gcaaggcttt tgtttttgga agaaaatcca gagtggtgga tctgaacctt      720

ctaacagagg aggtaagatt atacagctgc acacctcgta acttctcagt gtccataagg      780

gaagaactaa agagaaccga taccattttc tggccaggtt gtctcctggt taaacgctgt      840

ggtgggaact gtgcctgttg tctccacaat tgcaatgaat gtcaatgtgt cccaagcaaa      900

gttactaaaa aataccacga ggtccttcag ttgagaccaa agaccggtgt caggggattg      960

cacaaatcac tcaccgacgt ggccctggag caccatgagg agtgtgactg tgtgtgcaga     1020

gggagcacag gaggatag                                                   1038


<210>  114
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  114
atggctgcca aagtgtttga gtccattggc aagtttggcc tggccttagc tgttgcagga       60

ggcgtggtga actctgcctt atataatgtg gatgctgggc acagagctgt catctttgac      120

cgattccgtg gagtgcagga cattgtggta ggggaaggga ctcattttct catcccgtgg      180

gtacagaaac caattatctt tgactgccgt tctcgaccac gtaatgtgcc agtcatcact      240

ggtagcaaag atttacagaa tgtcaacatc acactgcgca tcctcttccg gcctgtcgcc      300

agccagcttc ctcgcatctt caccagcatc ggagaggact atgatgagcg tgtgctgccg      360

tccatcacaa ctgagatcct caagtcagtg gtggctcgct ttgatgctgg agaactaatc      420

acccagagag agctggtctc caggcaggtg agcgacgacc ttacagagcg agccgccacc      480

tttgggctca tcctggatga cgtgtccttg acacatctga ccttcgggaa ggagttcaca      540

gaagcggtgg aagccaaaca ggtggctcag caggaagcag agagggccag atttgtggtg      600

gaaaaggctg agcaacagaa aaaggcggcc atcatctctg ctgagggcga ctccaaggca      660

gctgagctga ttgccaactc actggccact gcaggggatg gcctgatcga gctgcgcaag      720

ctggaagctg cagaggacat cgcgtaccag ctctcacgct ctcggaacat cacctacctg      780

ccagcggggc agtccgtgct cctccagctg ccccagtga                             819


<210>  115
<211>  6120
<212>  DNA
<213>  Homo sapiens

<400>  115
atggatatag ttgatacatt taatcattta attcctactg aacacttaga tgatgcccta       60

tttctaggat ccaacctgga gaatgaagtc tgtgaggatt ttagtgcaag tcaaaatgtc      120

ttagaggact cgctgaagaa catgctcagc gataaggatc ctatgctagg atctgcaagt      180

aaccagttct gtttgcctgt tttggatagc aatgatccca atttccagat gccttgttca      240

acagttgttg gtcttgacga tattatggat gaaggagttg ttaaagaaag tggcaatgat      300

accattgatg aagaagaact gattttacct aacaggaact taagggacaa ggtagaagaa      360

aattcagtga gatctccaag aaaatcacct cgtttaatgg cacaagaaca agtaagaagt      420

ttgcgacaga gcactattgc caagcgttca aatgcagcac cattaagtaa cacaaaaaaa      480

gcatctggga agactgtatc tactgctaaa gcaggagtga aacaaccaga aaggagtcag      540

gttaaagaag aagtatgtat gtcactgaaa cctgagtacc ataaggagaa tagaaggtgc      600

agccgaaata gcggacaaat tgaagtggta cctgaagtat cagtgtcttc aagtcattct      660

tcagtgtcat cttgtcttga aatgaaggat gaagatggat tagattctaa gcataagtgt      720

aataatccgg gagaaataga tgtgccatct catgaattaa attgttcact tctttcagag      780

acttgtgtta ctattggaga aaagaaaaat gaagctttga tggaatgtaa agccaagcct      840

gttggtagtc cattgtttaa gttttcagat aaagaagaac atgaacaaaa tgattccatt      900

tcaggtaaaa cgggtgagac tgttgttgaa gaaatgatag caacaagaaa agttgaacaa      960

gattcaaagg agacagtaaa attatcccat gaagatgacc atattcttga ggacgctgga     1020

tcttctgata tttctagtga tgctgcttgt acaaatccaa ataagacaga aaacagcctt     1080

gtaggtttgc ctagttgtgt agatgaagtg actgaatgta atttggaatt gaaggatacc     1140

atgggtattg ctgataaaac tgagaacacc cttgaaagaa ataaaattga accgttgggt     1200

tattgtgaag atgcggagtc taataggcag ttggagagca ctgagtttaa taaatcaaac     1260

ttagaggtgg ttgatactag tacttttgga ccggaaagta atatcttgga aaatgctatt     1320

tgtgatgtgc ctgaccaaaa ttcaaaacag ttgaatgcta tagaaagtac taaaatagag     1380

tcccatgaaa cagcaaacct tcaggatgac agaaacagcc agtcaagtag cgtttcttac     1440

ttagagtcaa aaagtgtaaa atccaaacat acaaaacctg taattcattc taagcaaaac     1500

atgaccacag atgctccgaa gaaaattgtt gcagcaaagt atgaagtaat acatagcaaa     1560

actaaagtta atgtcaaaag tgtgaaacga aatactgatg taccagaatc tcagcaaaat     1620

tttcataggc cagtcaaagt cagaaaaaaa caaattgata aggagccaaa gattcagagt     1680

tgcaattctg gggttaaatc tgtgaaaaac caagctcatt ctgtactgaa aaaaacatta     1740

caggatcaaa ctttagtaca aattttcaag cccttaactc attctttgag tgataagtca     1800

cacgctcatc ctggttgctt gaaagaacct catcatcctg cacaaactgg acatgtatca     1860

cattctagcc agaaacagtg tcataagcct cagcaacagg ccccagcaat gaaaaccaat     1920

agtcacgtga aggaagagct tgaacaccca ggcgttgagc attttaagga agaggataaa     1980

ctgaaactga aaaaacctga gaagaaccta caaccccgcc aaagaagaag cagcaaaagt     2040

ttttctttag atgagccacc attgttcatt ccagataaca tagctaccat aagaagagaa     2100

ggctctgatc atagctcctc atttgaaagc aaatatatgt ggactcccag caagcagtgt     2160

gggttttgca aaaaaccaca tggcaacagg tttatggttg gctgtgggag atgtgatgac     2220

tggtttcatg gtgattgtgt tgggttaagt ctttctcaag cacagcagat gggcgaggaa     2280

gacaaagaat atgtctgtgt aaaatgttgt gctgaagaag acaaaaagac tgaaatacta     2340

gatccagata ctttggaaaa ccaagctaca gttgaattcc atagtggaga taaaacaatg     2400

gagtgtgaaa agcttggatt atcaaaacac acaacaaatg atagaaccaa atatatagat     2460

gatacagtga agcacaaggt caaaatttta aaacgggagt ctggtgaagg cagaaattca     2520

tcagactgta gagataatga aattaaaaaa tggcagctag ctcctcttcg taagatggga     2580

caaccagttt tacctcggag atcctcagaa gaaaaaagtg aaaaaatacc gaaagagtct     2640

acaactgtta cttgcacagg agaaaaagct tcaaaaccag gtactcatga gaagcaagag     2700

atgaaaaaga agaaagttga aaaaggagtg cttaatgtac atcctgctgc ttctgcttcc     2760

aagccttctg cagatcagat caggcaaagt gtcagacatt ctctcaaaga cattcttatg     2820

aagagactta cagactcaaa tttgaaggta ccagaggaaa aggcagcaaa agttgccaca     2880

aaaattgaga aagagctttt ctcttttttt cgggacacag atgctaaata taagaacaaa     2940

tatagaagtt tgatgtttaa tttgaaagat cctaaaaaca atatattatt taaaaaagta     3000

ctgaaaggag aagtaactcc tgatcatctt atcagaatga gtccagaaga actagcttct     3060

aaagagttag ctgcttggag acgaagagaa aacagacata ccatagaaat gattgagaaa     3120

gagcagagag aagtggaacg acggccaatc accaaaataa ctcataaagg tgaaatagaa     3180

attgagagtg atgccccaat gaaagaacag gaagcagcca tggagattca ggaaccagcc     3240

gccaataagt cattggagaa gccagaagga tctgaaaaac aaaaagagga ggttgactct     3300

atgtctaaag ataccactag tcaacacaga cagcatcttt ttgatctcaa ctgcaaaatc     3360

tgcataggtc gaatggcacc acctgtagat gatctttctc caaaaaaagt aaaagttgtt     3420

gtaggagtag ctcgcaaaca ttcagacaat gaagcagaaa gtatagcaga tgcattatct     3480

tcaacctcaa atattttggc ttctgaattc tttgaggagg agaaacagga gtctccaaag     3540

tcaacgttct ctcctgctcc acgtccagag atgcctggaa ctgttgaagt tgagtctacc     3600

tttctggctc gattgaactt catctggaaa ggttttatca acatgccttc tgtggcaaaa     3660

tttgttacca aagcctatcc agtatctggc tccccagaat acctgacaga ggacctacca     3720

gatagtattc aagtaggtgg caggatatca cctcagacag tttgggatta tgtggaaaaa     3780

ataaaagcat caggaaccaa ggaaatttgt gtggttcgct tcacaccagt aactgaagaa     3840

gatcaaattt cttatacttt gctctttgca tacttcagta gcagaaagcg ctatggagta     3900

gctgctaaca acatgaagca ggttaaagat atgtacctta ttcctttggg tgccacagat     3960

aaaattccac accctcttgt gccttttgat ggacctgggc ttgaactgca tagacctaat     4020

ctattgttgg gcttaattat tcgtcagaaa ctgaagcgac agcacagtgc ctgtgctagt     4080

actagtcata tagctgagac tcctgaaagt gcaccaccaa tagcattgcc acctgataaa     4140

aaaagtaaaa tagaagtttc tacagaagaa gcaccagagg aagaaaatga cttttttaat     4200

tcttttacaa ctgtattaca caagcagaga aataaacctc agcagaatct tcaggaagac     4260

cttccaacag cagttgaacc tttaatggaa gtcaccaaac aggagccacc aaaaccttta     4320

agatttcttc ctggcgtgtt gattggctgg gagaatcaac ctactactct ggaattagca     4380

aataaacctc ttcctgtgga tgatatactt caaagccttt tgggcaccac tggtcaagta     4440

tatgaccagg cccagtcagt gatggaacaa aacactgtta aagaaattcc atttttaaat     4500

gagcagacca actcaaaaat agagaaaaca gataatgtgg aagtaactga tggtgaaaac     4560

aaggagataa aagttaaagt agataatatt tcagaatcta cagataagtc agcagaaata     4620

gaaacatcag tagtagggtc ctcttccatt tctgcagggt ctttgacgag tcttagtctc     4680

agaggtaagc caccagatgt ttctacagaa gcatttttaa caaatttatc aattcagtca     4740

aaacaagagg aaactgtgga gagtaaagag aaaacattaa aaagacagct tcaggaagat     4800

caagagaata atttgcaaga taaccagact tcaaatagtt ctccatgcag atctaatgta     4860

ggaaaaggaa acatagatgg taatgtgagc tgtagtgaaa accttgttgc taatacagcg     4920

aggtctccac agtttatcaa cctgaaaagg gatcctaggc aagcagcagg acgaagtcag     4980

cctgtaacta cttcagaaag caaagatgga gatagttgcc ggaatggaga aaaacacatg     5040

ctgcctggcc tgtcacacaa caaggagcac ttaacagaac aaatcaatgt agaggaaaag     5100

ttgtgttctg cagagaaaaa ctcgtgtgtt cagcagagtg acaatttaaa agttgcacaa     5160

aactcaccat cagtagaaaa catacagact tctcaagcag aacaagcaaa acccttacag     5220

gaggatattt taatgcaaaa tattgaaact gtgcacccat ttcgaagagg atcagcagta     5280

gcgacatctc attttgaagt tggaaacaca tgtccatcag aatttccttc taaaagcatc     5340

acctttactt ccagaagcac cagccccaga acaagtacaa acttttcacc catgaggcca     5400

cagcagccca accttcagca tctcaagtct agcccacctg gatttccatt tccagggcct     5460

cctaattttc ccccacaaag catgtttgga tttccaccac atttgccacc tccattactt     5520

ccccctccag gctttggctt tgctcaaaat cccatggttc cctggccacc tgttgttcat     5580

ctcccaggtc agccacagcg tatgatgggt cctctctcac aagcatcaag gtatataggc     5640

ccgcagaatt tttaccaggt taaagacatt cggaggccag aaaggcgcca tagtgaccct     5700

tggggtaggc aagaccaaca gcaactggat aggccattta ataggggtaa aggggaccgc     5760

cagagatttt atagtgattc acaccatttg aaaagagagc gacatgaaaa ggaatgggag     5820

caagaatctg aaaggcatag acgcagagac agaagccaag acaaggacag agacagaaaa     5880

agcagggagg aagggcacaa agataaagag agggcacggt tatcacatgg tgatcgagga     5940

acagatggaa aagcaagcag agatagtagg aatgtagaca agaagccaga taaacctaaa     6000

agtgaagact atgagaagga caaagaacga gagaaaagta aacacagaga aggagaaaag     6060

gacagggata ggtaccacaa agatagggac cacactgaca gaactaaaag caaaaggtaa     6120


<210>  116
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  116
atgcaagctc aggcgccggt ggtcgttgtg acccaacctg gagtcggtcc cggtccggcc       60

ccccagaact ccaactggca gacaggcatg tgtgactgtt tcagcgactg cggagtctgt      120

ctctgtggca cattttgttt cccgtgcctt gggtgtcaag ttgcagctga tatgaatgaa      180

tgctgtctgt gtggaacaag cgtcgcaatg aggactctct acaggacccg atatggcatc      240

cctggatcta tttgtgatga ctatatggca actctttgct gtcctcattg tactctttgc      300

caaatcaaga gagatatcaa cagaaggaga gccatgcgta ctttctaa                   348


<210>  117
<211>  3492
<212>  DNA
<213>  Homo sapiens

<400>  117
atgcctgtgt ccacctccct ccaccaggat ggcagccagg agcggccggt gagcctgacc       60

tctaccacct cctcgtcggg ctcctcctgt gacagtcgca gtgccatgga ggagcccagc      120

agctccgagg ctcccgccaa gaatggggca ggctccctga gaagccggca tctgcccaac      180

agcaacaaca actccagcag ctggttgaac gtgaaggggc ccctctcccc gttcaacagc      240

cgggcagcgg cagggcctgc acaccacaag ctcagctacc tgggccgagt ggtgcgggag      300

atcgtggaga cagagcgcat gtacgtacag gacctgcgca gcatcgtgga gagccaagag      360

tttgatatct acactcagta ttgcaacaat taccccaact ccgtggccgc cctgacggaa      420

tgcatgcggg acaagcagca ggccaagttc tttcgggacc ggcaggagct gctacagcac      480

tcgctgccct tgggctccta cctgctgaag ccagtccagc gcatcctcaa gtaccacctg      540

ctgctccagg aaattgccaa gcattttgat gaagaagagg atggctttga ggtggtggag      600

gatgccattg acaccatgac ctgtgtggcc tggtacatca acgacatgaa gaggaggcat      660

gagcacgcgg tccggctcca ggagattcag tcactcctca tcaactggaa ggggcccgac      720

ctgaccacct acggggagct tgtcctggag ggcacattcc gcgtgcatcg cgtgcgcaat      780

gaaaggacct ttttcctctt tgacaaaaca ctgcttatca ccaagaagcg gggcgatcac      840

tttgtctaca agggcaacat cccgtgctcc tccctgatgc tgatcgaaag caccagagac      900

tccctgtgct tcactgtcac ccactacaag cacagcaagc agcagtacag catccaggcc      960

aagacagtgg aggagaaacg gaactggact caccacatca agaggctcat cctagagaac     1020

caccatgcca ccattcccca gaaggccaag gaagccatct tggaaatgga ttcctattat     1080

cccaatcggt accgctgcag cccagagcgg ctgaagaagg cttggtcctc ccaggatgag     1140

gtgtccacca atgtgcgcca ggggcgccgg caatctgagc caaccaaaca cctgctcagg     1200

caactcaacg agaaagcccg agcagcagga atgaagggaa aggggcgcag ggagtctgaa     1260

agctccagga gcagcagaag gcccagtggc cggtctccaa ccagtactga gaagcgcatg     1320

agcttcgagt ccatttcttc cctgccagag gttgagccgg accctgaggc tgggagtgag     1380

caagaggtat tttctgctgt ggaagggccc agtgccgagg agacgccttc agacacagaa     1440

tctccagaag tcctggagac acagcttgat gcccaccagg gccttctggg gatggacccc     1500

ccaggtgaca tggtggactt cgtggcagct gagagcactg aggaccttaa ggccctgagc     1560

agcgaggagg aagaagaaat gggaggtgcc gcccaggagc ctgagagcct tctgccaccc     1620

tctgtgctgg accaggccag cgtcattgcg gagcgatttg tcagcagctt ctctcggcgg     1680

agcagcgtgg cacaggagga cagcaagtcc agtggctttg ggagcccgcg gctggtcagc     1740

cggagcagca gcgtgctcag cctggagggc agcgagaagg gcctggcccg gcatggcagt     1800

gccacagact ccctcagctg tcagctctcc ccagaagtgg acatcagtgt gggggtggcc     1860

acagaggaca gcccttctgt caatgggatg gagcccccaa gcccaggctg cccagtggag     1920

cctgaccggt cttcctgcaa gaagaaggaa tcagcactct ccacccgaga ccggctgttg     1980

ctagacaaga ttaagagcta ttatgaaaat gcagaacacc atgatgcagg cttcagcgtc     2040

cgtcgccggg agagcctctc ctacatcccc aaaggactgg taagaaactc catctccagg     2100

ttcaacagcc ttccccggcc agacccagag ccagtacctc cagtggggag caagagacag     2160

gtgggctccc ggccgacttc gtgggccctg tttgagctcc caggaccaag ccaggcagtc     2220

aaaggggacc cacctcccat ctcagatgct gagttccgcc catcttcaga aattgtgaag     2280

atctgggagg gaatggagtc ttccggaggg agccctggga aggggccagg ccagggccag     2340

gccaatggct ttgacctgca tgagccactc ttcatcctgg aggagcatga gctgggagcc     2400

atcacagagg agtcggccac tgcctccccg gaaagctcct ctcccactga ggggcgcagc     2460

ccggcccacc tggcccggga gctgaaagag ctggtgaagg agctgagcag cagtacccag     2520

ggggagctgg tggccccact gcacccccgc atcgtgcagc tctcccacgt aatggacagc     2580

cacgtgagcg agcgcgtcaa gaacaaggtc taccagctgg cccgccagta cagcctccgg     2640

atcaagagca acaagccagt gatggccagg ccaccactgc agtgggaaaa ggtggcccct     2700

gagagggatg ggaagagccc cactgtgccc tgtctacagg aagaggctgg agagccatta     2760

ggtggcaaag gtaagaggaa gccggtgctg tctctatttg actatgagca gctgatggcc     2820

caggagcaca gccctcccaa gccctcctcg gctggggaga tgtcaccaca gcgtttcttc     2880

ttcaacccgt ctgctgtcag ccagaggacc acctcgcctg ggggccggcc ctccgcccgg     2940

agccccctca gccccacaga gaccttcagc tggcccgacg tccgtgagct ctgctccaag     3000

tatgcctccc gcgatgaggc acgccgagca gggggcggcc ggccccgcgg cccacccgtc     3060

aacaggagcc actcggtgcc ggagaacatg gtagagccac ctctgtcggg cagggtgggc     3120

cgctgccgca gcctgagcac caagaggggc cggggaggcg gagaggctgc ccaatcccct     3180

gggcctctgc cccagagcaa gccggatgga ggcgagaccc tgtatgtcac tgcagacctc     3240

accctggagg acaaccggcg ggtgattgtc atggagaagg gaccccttcc cagccccact     3300

gcagggctgg aggagagcag tggccaggga ccaagctcac cggtggccct gctggggcag     3360

gttcaggact tccagcagtc tgcagagtgc cagccgaagg aagagggttc cagggacccg     3420

gcagacccga gccagcaggg cagagtgaga aaccttagag agaagttcca ggccttgaac     3480

tctgtcggtt ga                                                         3492


<210>  118
<211>  3060
<212>  DNA
<213>  Homo sapiens

<400>  118
atggagccgg gggaggtgaa ggaccggatc ctggagaaca tctcgctgtc ggtgaagaag       60

ttgcagagct attttgctgc atgtgaggat gagatccctg ccatccggaa ccatgacaag      120

gtcctacagc gtctgtgtga gcacctggac cacgccctgc tgtacggact gcaagacctc      180

tcctctggct actgggtgct cgtggtgcat tttactcgga gagaggccat caagcagatc      240

gaggtgctgc agcacgtggc caccaacctg gggcgcagcc gtgcctggct gtacctggcc      300

ctcaacgaga actccttgga gagctacctg cggttgttcc aggagaacct gggcctgctg      360

cataagtact acgtcaagaa tgccctggtc tgcagccacg atcacctgac gctcttcctg      420

accttggtgt ccgggctaga gttcattcgt ttcgagctgg atctggatgc cccttaccta      480

gacctggccc cctacatgcc cgactactac aaacctcagt acctgctgga ctttgaagac      540

cgccttccca gctcggtcca cggctcagac agtctgtccc tcaactcttt caactccgtc      600

acctccacca acctggagtg ggatgacagt gcgattgccc catctagtga ggattatgat      660

tttggagatg tgtttccagc agtgccgtct gtacccagca cagactggga agatggagac      720

ctcacagaca cggtcagtgg tccccgctcc acagcctccg acctgaccag cagcaaggcc      780

tccaccagga gccccaccca gcgccagaac cccttcaacg aggagccggc agagactgtg      840

tcctcctctg acaccacccc cgtgcacacc acctctcagg agaaggagga ggcccaggcc      900

ctggacccgc cggatgcctg cacggagctc gaggtcatca gggtcaccaa gaagaagaaa      960

attggcaaga agaaaaagag cagatcagat gaggaggcaa gtccactcca ccccgcctgc     1020

agccagaaga aatgtgccaa gcagggggac ggtgacagcc gcaacggcag cccaagcctt     1080

gggcgggact cgccagacac tatgcttgcc tccccccagg aggagggaga ggggccgagc     1140

agcaccacgg agagcagcga gcgctccgag ccgggcctgc tgatccctga gatgaaggac     1200

acctccatgg agcgcttggg gcagcccctg agcaaggtta tcgaccagct caacgggcag     1260

ctggacccca gcacctggtg ctcccgtgct gagcccccag accagtcctt tcggaccggc     1320

tctcccgggg atgccccgga gaggccgccg ctttgcgact ttagtgaggg gctttcagcc     1380

ccaatggact tctaccgctt taccgtcgag agtccaagca ctgttacatc aggtggcggc     1440

caccatgacc ctgcagggct tggccaaccg ctgcatgttc ctagtagccc tgaggctgct     1500

ggccaagaag aagagggagg aggaggagag ggacagacgc ctcggcccct agaggatacc     1560

acgagggagg ctcaggagct ggaggcccag ctgtccctgg tcagggaggg gcctgtgtct     1620

gagccagagc ctgggaccca ggaggttctc tgccagctca agcgagacca gcccagcccg     1680

tgtctgagta gcgctgagga ttctggggtg gatgagggac aggggagccc ttcggagatg     1740

gtccattcct cggagttcag agtagacaac aatcacctgc tcctgctcat gatccacgtg     1800

ttccgagaaa acgaagagca gctgttcaaa atgatccgga tgagcaccgg gcacatggag     1860

ggcaacctgc agctgctgta cgtgctgctc acagactgct atgtctacct gctccggaaa     1920

ggggccacag agaagccata cctggtggaa gaggccgttt cttacaatga acttgactat     1980

gtgtcggttg gccttgacca gcagacggtg aagctggtgt gcaccaaccg caggaagcag     2040

tttctgctgg acacggctga tgtggcgctg gctgagttct ttttggcttc tttgaagtca     2100

gccatgatca aaggctgtcg agaacctccc taccccagca tcctgacgga tgccaccatg     2160

gagaagctgg cactggccaa atttgtggcc caagaatcga agtgtgaggc atctgctgtc     2220

accgtgcgct tctacggcct tgtgcactgg gaggacccca cagacgagtc cctgggcccc     2280

acgccctgcc actgctcacc ccccgagggc accatcacca aagaaggcat gctgcactac     2340

aaggcgggca cctcctacct gggcaaggaa cactggaaga cgtgcttcgt ggtgctcagc     2400

aacgggatcc tctaccagta cccggaccgc accgacgtca tccctctgct ctcggtgaac     2460

atgggggggg agcagtgcgg tggctgccgg agagccaaca ccacggatcg gccccacgcc     2520

ttccaggtca ttctctccga ccggccctgc ctggagctaa gtgccgagag cgaggccgag     2580

atggccgagt ggatgcagca tctctgccag gctgtgtcca aaggggtcat cccccagggc     2640

gtagctccca gcccctgcat accctgctgc ctggtcctca cggatgaccg cctctttacg     2700

tgccatgagg attgccagac cagcttcttc cgctctttgg gcacagccaa gctgggcgac     2760

atcagcgccg tctccaccga gccgggcaag gagtactgcg tcttggagtt ctcccaggac     2820

agccagcagc tcctcccgcc ctgggtcatc tacctgagct gcacttctga actggaccga     2880

ttgctgtctg cactgaactc tgggtggaaa accatctatc aggtggacct cccccacacg     2940

gcgatccagg aagcctccaa caagaagaaa ttcgaggatg ccttgagcct catccacagc     3000

gcctggcagc ggagcgacag tctctgccgc ggccgagcct cccgagaccc ctggtgctga     3060


<210>  119
<211>  828
<212>  DNA
<213>  Homo sapiens

<400>  119
atgccgtacg ccaaccagcc taccgtgcgg atcacggagc tcactgacga gaatgtcaag       60

ttcatcatcg agaacaccga cctggcggtg gccaattcga ttcggagggt cttcatcgct      120

gaggttccca taatagccat tgactgggtt cagattgatg ccaattcctc agttcttcat      180

gatgaattca ttgctcacag gcttggatta attcccctca ttagtgatga cattgtggac      240

aagctgcagt actctcggga ctgcacatgt gaggagttct gccccgagtg ctcggtggag      300

ttcaccctcg atgtgcggtg caatgaagac cagacgcgac atgtcacgtc tcgagacctc      360

atctccaaca gcccccgggt cattccggtg acatcccgga accgagataa tgaccccaat      420

gactacgtgg agcaggatga catcctcatc gtcaagttga gaaagggcca ggagctgaga      480

cttcgagcct atgccaaaaa gggctttggc aaggagcatg ccaagtggaa ccctactgca      540

ggggtggctt ttgaatacga tccagacaat gccctgaggc acacagtgta ccccaagccc      600

gaggaatggc caaagagtga gtactcggag ctggatgagg atgagtcgca ggctccctat      660

gaccccaacg gcaagccaga aaggttttac tacaatgtgg agtcctgtgg ctctctgcgt      720

cctgaaacca ttgtcctgtc agccctctca ggattgaaga agaaactgag tgatttacaa      780

actcaattaa gccacgagat ccagagtgat gtgctaacca taaattaa                   828


<210>  120
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  120
atgtccgaca gcgagaagct caacctggac tcgatcatcg ggcgcctgct ggaagtgcag       60

ggctcgcggc ctggcaagaa tgtacagctg acagagaacg agatccgcgg tctgtgcctg      120

aaatcccggg agatttttct gagccagccc attcttctgg agctggaggc acccctcaag      180

atctgcggtg acatacacgg ccagtactac gaccttctgc gactatttga gtatggcggt      240

ttccctcccg agagcaacta cctctttctg ggggactatg tggacagggg caagcagtcc      300

ttggagacca tctgcctgct gctggcctat aagatcaagt accccgagaa cttcttcctg      360

ctccgtggga accacgagtg tgccagcatc aaccgcatct atggtttcta cgatgagtgc      420

aagagacgct acaacatcaa actgtggaaa accttcactg actgcttcaa ctgcctgccc      480

atcgcggcca tagtggacga aaagatcttc tgctgccacg gaggcctgtc cccggacctg      540

cagtctatgg agcagattcg gcggatcatg cggcccacag atgtgcctga ccagggcctg      600

ctgtgtgacc tgctgtggtc tgaccctgac aaggacgtgc agggctgggg cgagaacgac      660

cgtggcgtct cttttacctt tggagccgag gtggtggcca agttcctcca caagcacgac      720

ttggacctca tctgccgagc acaccaggtg gtagaagacg gctacgagtt ctttgccaag      780

cggcagctgg tgacactttt ctcagctccc aactactgtg gcgagtttga caatgctggc      840

gccatgatga gtgtggacga gaccctcatg tgctctttcc agatcctcaa gcccgccgac      900

aagaacaagg ggaagtacgg gcagttcagt ggcctgaacc ctggaggccg acccatcacc      960

ccaccccgca attccgccaa agccaagaaa tag                                   993


<210>  121
<211>  984
<212>  DNA
<213>  Homo sapiens

<400>  121
atggcggacg gggagctgaa cgtggacagc ctcatcaccc ggctgctgga ggtacgagga       60

tgtcgtccag gaaagattgt gcagatgact gaagcagaag ttcgaggctt atgtatcaag      120

tctcgggaga tctttctcag ccagcctatt cttttggaat tggaagcacc gctgaaaatt      180

tgtggagata ttcatggaca atatacagat ttactgagat tatttgaata tggaggtttc      240

ccaccagaag ccaactatct tttcttagga gattatgtgg acagaggaaa gcagtctttg      300

gaaaccattt gtttgctatt ggcttataaa atcaaatatc cagagaactt ctttctctta      360

agaggaaacc atgagtgtgc tagcatcaat cgcatttatg gattctatga tgaatgcaaa      420

cgaagattta atattaaatt gtggaagacc ttcactgatt gttttaactg tctgcctata      480

gcagccattg tggatgagaa gatcttctgt tgtcatggag gattgtcacc agacctgcaa      540

tctatggagc agattcggag aattatgaga cctactgatg tccctgatac aggtttgctc      600

tgtgatttgc tatggtctga tccagataag gatgtgcaag gctggggaga aaatgatcgt      660

ggtgtttcct ttacttttgg agctgatgta gtcagtaaat ttctgaatcg tcatgattta      720

gatttgattt gtcgagctca tcaggtggtg gaagatggat atgaattttt tgctaaacga      780

cagttggtaa ccttattttc agccccaaat tactgtggcg agtttgataa tgctggtgga      840

atgatgagtg tggatgaaac tttgatgtgt tcatttcaga tattgaaacc atctgaaaag      900

aaagctaaat accagtatgg tggactgaat tctggacgtc ctgtcactcc acctcgaaca      960

gctaatccgc cgaagaaaag gtga                                             984


<210>  122
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  122
atggccgagg caggggctgg gctgagcgag accgtcactg agacaacggt taccgtgaca       60

accgagcccg agaaccggag ccttaccatc aaacttcgga aacggaagcc agagaaaaag      120

gtagaatgga caagtgacac tgtggacaat gaacacatgg gccgccgctc atccaaatgc      180

tgctgtattt atgagaaacc tcgggccttt ggcgagagct ccacggaaag tgatgaggag      240

gaagaagagg gctgtggtca tacacactgt gtacgtggcc accgcaaagg acggcgtcgt      300

gcaaccctag gaccgacccc caccacccct ccccagcctc ctgacccttc ccagccccct      360

ccagggccaa tgcagcacta a                                                381


<210>  123
<211>  2031
<212>  DNA
<213>  Homo sapiens

<400>  123
atgagggtcc tgggtgggcg ctgcggggcg ctgctggcgt gtctcctcct agtgcttccc       60

gtctcagagg caaacttttt gtcaaagcaa caggcttcac aagtcctggt taggaagcgt      120

cgtgcaaatt ctttacttga agaaaccaaa cagggtaatc ttgaaagaga atgcatcgaa      180

gaactgtgca ataaagaaga agccagggag gtctttgaaa atgacccgga aacggattat      240

ttttatccaa aatacttagt ttgtcttcgc tcttttcaaa ctgggttatt cactgctgca      300

cgtcagtcaa ctaatgctta tcctgaccta agaagctgtg tcaatgccat tccagaccag      360

tgtagtcctc tgccatgcaa tgaagatgga tatatgagct gcaaagatgg aaaagcttct      420

tttacttgca cttgtaaacc aggttggcaa ggagaaaagt gtgaatttga cataaatgaa      480

tgcaaagatc cctcaaatat aaatggaggt tgcagtcaaa tttgtgataa tacacctgga      540

agttaccact gttcctgtaa aaatggtttt gttatgcttt caaataagaa agattgtaaa      600

gatgtggatg aatgctcttt gaagccaagc atttgtggca cagctgtgtg caagaacatc      660

ccaggagatt ttgaatgtga atgccccgaa ggctacagat ataatctcaa atcaaagtct      720

tgtgaagata tagatgaatg ctctgagaac atgtgtgctc agctttgtgt caattaccct      780

ggaggttaca cttgctattg tgatgggaag aaaggattca aacttgccca agatcagaag      840

agttgtgagg ttgtttcagt gtgccttccc ttgaaccttg acacaaagta tgaattactt      900

tacttggcgg agcagtttgc aggggttgtt ttatatttaa aatttcgttt gccagaaatc      960

agcagatttt cagcagaatt tgatttccgg acatatgatt cagaaggcgt gatactgtac     1020

gcagaatcta tcgatcactc agcgtggctc ctgattgcac ttcgtggtgg aaagattgaa     1080

gttcagctta agaatgaaca tacatccaaa atcacaactg gaggtgatgt tattaataat     1140

ggtctatgga atatggtgtc tgtggaagaa ttagaacata gtattagcat taaaatagct     1200

aaagaagctg tgatggatat aaataaacct ggaccccttt ttaagccgga aaatggattg     1260

ctggaaacca aagtatactt tgcaggattc cctcggaaag tggaaagtga actcattaaa     1320

ccgattaacc ctcgtctaga tggatgtata cgaagctgga atttgatgaa gcaaggagct     1380

tctggaataa aggaaattat tcaagaaaaa caaaataagc attgcctggt tactgtggag     1440

aagggctcct actatcctgg ttctggaatt gctcaatttc acatagatta taataatgta     1500

tccagtgctg agggttggca tgtaaatgtg accttgaata ttcgtccatc cacgggcact     1560

ggtgttatgc ttgccttggt ttctggtaac aacacagtgc cctttgctgt gtccttggtg     1620

gactccacct ctgaaaaatc acaggatatt ctgttatctg ttgaaaatac tgtaatatat     1680

cggatacagg ccctaagtct atgttccgat caacaatctc atctggaatt tagagtcaac     1740

agaaacaatc tggagttgtc gacaccactt aaaatagaaa ccatctccca tgaagacctt     1800

caaagacaac ttgccgtctt ggacaaagca atgaaagcaa aagtggccac atacctgggt     1860

ggccttccag atgttccatt cagtgccaca ccagtgaatg ccttttataa tggctgcatg     1920

gaagtgaata ttaatggtgt acagttggat ctggatgaag ccatttctaa acataatgat     1980

attagagctc actcatgtcc atcagtttgg aaaaagacaa agaattctta a              2031


<210>  124
<211>  2793
<212>  DNA
<213>  Homo sapiens

<400>  124
atgtgtagcg gcagtggccg ccggcggagc agtctgagcc cgacgatgag gccggggacg       60

ggagctgagc gtggaggcct catgatgggg caccctggca tgcattatgc cccaatggga      120

atgcacccta tgggtcagag agcgaatatg cctcctgtac ctcatggaat gatgccgcag      180

atgatgcccc ctatgggagg gccaccaatg ggacaaatgc ctggaatgat gtcgtcagta      240

atgcctggaa tgatgatgtc tcatatgtct caggcttcca tgcagcctgc cttaccgcca      300

ggagtaaata gtatggatgt agcagcaggt acagcatctg gtgcaaaatc aatgtggact      360

gaacataaat cacctgatgg aaggacttac tactacaaca ctgaaaccaa acagtctacc      420

tgggagaaac cagatgatct taaaacacct gctgagcaac tcttatctaa atgcccctgg      480

aaggaataca aatcagattc tggaaagcct tactattata attctcaaac aaaagaatct      540

cgctgggcca aacctaaaga acttgaggat cttgaaggat accagaatac cattgttgct      600

ggaagtctta ttacaaaatc aaacctgcat gcaatgatca aagctgaaga aagcagtaag      660

caagaagagt gcaccacaac atcaacagcc ccagtcccta caacagaaat tccgaccaca      720

atgagcacca tggctgctgc cgaagcagca gctgctgttg ttgcagcagc agcagcggca      780

gcagcagcag cagctgcagc caatgctaat gcttccactt ctgcttctaa tactgtcagt      840

ggaactgttc cagttgttcc tgagcctgaa gttacttcca ttgttgctac tgttgtagat      900

aatgagaata cagtaactat ttcaactgag gaacaagcac aacttactag tacccctgct      960

attcaggatc aaagtgtgga agtatccagt aatactggag aagaaacatc taagcaagaa     1020

actgtagctg attttactcc caaaaaagaa gaggaggaga gccaaccagc aaagaaaaca     1080

tacacttgga atacaaagga agaggcaaag caagctttta aagaattatt gaaagaaaag     1140

cgggtaccat cgaatgcttc atgggagcag gctatgaaaa tgattattaa tgatccacga     1200

tacagtgctt tggcaaagtt aagtgaaaaa aagcaagcct ttaatgccta taaagtccag     1260

acagaaaaag aagaaaaaga agaagcaaga tcaaagtaca aagaggctaa ggaatccttt     1320

cagcgttttc ttgaaaatca tgagaaaatg acttctacaa ccagatacaa aaaagcagag     1380

caaatgtttg gagagatgga agtttggaat gcaatatcag aacgtgatcg tcttgaaatc     1440

tatgaagatg ttttgttctt tctttcaaaa aaagaaaagg aacaagcaaa gcagttgcga     1500

aagagaaatt gggaagcctt aaaaaacata cttgacaaca tggctaatgt aacatactct     1560

accacttggt ctgaagccca gcagtatctg atggataatc caacttttgc agaagatgag     1620

gagttacaaa atatggacaa agaagatgca ttaatttgct ttgaagaaca cattcgggct     1680

ttagaaaagg aggaagaaga agaaaaacag aagagtttgc tgagagaaag gagacgacag     1740

cgaaaaaata gggaatcttt ccagatattt ttagatgaat tacatgaaca tggacaactg     1800

cattctatgt catcttggat ggaattgtat ccaactatta gttctgatat tagattcact     1860

aatatgcttg gtcagcctgg atcaactgca cttgatcttt tcaagtttta tgttgaggat     1920

cttaaagcac gttatcatga cgagaagaag ataataaaag acattctaaa ggataaagga     1980

tttgtagttg aagtaaacac tacttttgaa gattttgtgg cgataatcag ttcaactaaa     2040

agatcaacta cattagatgc tggaaatatc aaattggctt tcaatagttt actagaaaag     2100

gcagaagccc gtgaacgtga aagagaaaaa gaagaggctc ggaagatgaa acgaaaagaa     2160

tctgcattta agagtatgtt aaaacaagct gctcctccga tagaattgga tgctgtctgg     2220

gaagatatcc gtgagagatt tgtaaaagag ccagcatttg aggacataac tctagaatct     2280

gaaagaaaac gaatatttaa agattttatg catgtgcttg agcatgaatg tcagcatcat     2340

cattcaaaga acaagaaaca ttctaagaaa tctaaaaaac atcataggaa acgttcccgc     2400

tctcgatcgg ggtcagattc agatgatgat gatagccatt caaagaaaaa aagacagcga     2460

tcagagtctc gttctgcttc agaacattct tctagtgcag agtctgagag aagttataaa     2520

aagtcaaaaa agcataagaa gaaaagtaag aagaggagac ataaatctga ctctccagaa     2580

tccgatgctg agcgagagaa ggataaaaaa gaaaaagatc gggaaagtga aaaagacaga     2640

actagacaaa gatcagaatc aaaacacaaa tcgcctaaga aaaagactgg aaaggattct     2700

ggtaattggg atacttctgg cagcgaactg agtgaagggg aattggaaaa gcgcagaaga     2760

acccttttgg agcaactgga tgatgatcaa taa                                  2793


<210>  125
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  125
atgtttacgc ttctggttct actcagccaa ctgcccacag ttaccctggg gtttcctcat       60

tgcgcaagag gtccaaaggc ttctaagcat gcgggagaag aagtgtttac atcaaaagaa      120

gaagcaaact ttttcataca tagacgcctt ctgtataata gatttgatct ggagctcttc      180

actcccggca acctagaaag agagtgcaat gaagaacttt gcaattatga ggaagccaga      240

gagatttttg tggatgaaga taaaacgatt gcattttggc aggaatattc agctaaagga      300

ccaaccacaa aatcagatgg caacagagag aaaatagatg ttatgggcct tctgactgga      360

ttaattgctg ctggagtatt tttggttatt tttggattac ttggctacta tctttgtatc      420

actaagtgta ataggctaca acatccatgc tcttcagccg tctatgaaag ggggaggcac      480

actccctcca tcattttcag aagacctgag gaggctgcct tgtctccatt gccgccttct      540

gtggaggatg caggattacc ttcttatgaa caggcagtgg cgctgaccag aaaacacagt      600

gtttcaccac caccaccata tcctgggcac acaaaaggat ttagggtatt taaaaaatct      660

atgtctctcc catctcactg a                                                681


<210>  126
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  126
atggaagcgt ttttggggtc gcggtccgga ctttgggcgg ggggtccggc cccaggacag       60

ttttaccgca ttccgtccac tcccgattcc ttcatggatc cggcgtctgc actttacaga      120

ggtccaatca cgcggaccca gaaccccatg gtgaccggga cctcagtcct cggcgttaag      180

ttcgagggcg gagtggtgat tgccgcagac atgctgggat cctacggctc cttggctcgt      240

ttccgcaaca tctctcgcat tatgcgagtc aacaacagta ccatgctggg tgcctctggc      300

gactacgctg atttccagta tttgaagcaa gttctcggcc agatggtgat tgatgaggag      360

cttctgggag atggacacag ctatagtcct agagctattc attcatggct gaccagggcc      420

atgtacagcc ggcgctcgaa gatgaaccct ttgtggaaca ccatggtcat cggaggctat      480

gctgatggag agagcttcct cggttatgtg gacatgcttg gtgtagccta tgaagcccct      540

tcgctggcca ctggttatgg tgcatacttg gctcagcctc tgctgcgaga agttctggag      600

aagcagccag tgctaagcca gaccgaggcc cgcgacttag tagaacgctg catgcgagtg      660

ctgtactacc gagatgcccg ttcttacaac cggtttcaaa tcgccactgt caccgaaaaa      720

ggtgttgaaa tagagggacc attgtctaca gagaccaact gggatattgc ccacatgatc      780

agtggctttg aatga                                                       795


<210>  127
<211>  1005
<212>  DNA
<213>  Homo sapiens

<400>  127
atgacgcgct cactgttcaa gggaaacttt tggagtgcag acatcctcag caccatcggc       60

tatgacaaca ttatccaaca tctgaacaat ggccgcaaga actgcaaaga gtttgaagac      120

tttctaaaag aaagggcagc aattgaagag aggtatggca aagatctgct caacctctct      180

aggaagaagc cgtgtggaca gtctgaaatc aacaccctga agcgggccct tgaagtcttc      240

aagcagcaag tagacaatgt ggcacaatgt cacattcagc ttgcacagag tttaagagaa      300

gaggccagga agatggaaga attcagggaa aagcaaaaac tacaacgaaa aaagacagag      360

ctcataatgg atgctatcca taaacaaaag agcttacaat tcaagaaaac catggatgca      420

aagaagaact atgagcagaa atgccgggac aaagatgagg cagaacaggc cgtcagccgg      480

agtgccaacc tggtgaaccc gaagcaacaa gaaaagcttt ttgtgaaact ggcaacttca      540

aagaccgcag tagaggactc agacaaagca tacatgctgc acatcggcac cctggataag      600

gtccgagaag agtggcagag tgagcacatc aaggcctgcg aggcatttga ggctcaagaa      660

tgtgaacgaa taaacttctt ccggaatgca ttgtggttac atgtgaatca gctgtcacaa      720

caatgtgtca ccagtgatga aatgtacgaa caagtccgaa agagtttaga aatgtgcagc      780

attcagaggg acattgaata ctttgtgaat caacgcaaaa ctggacagat tccaccagca      840

cccatcatgt atgagaattt ctactcctcc cagaagaatg cagtcccagc aggaaaggct      900

acagggccta acttggcaag gagaggaccc ctcccaattc ctaaaagctc accagatgat      960

cccaattact ctttggttga tgactacagt ttgctctatc agtaa                     1005


<210>  128
<211>  1248
<212>  DNA
<213>  Homo sapiens

<400>  128
atgcccacca ccatcgagcg ggagttcgaa gagttggata ctcagcgtcg ctggcagccg       60

ctgtacttgg aaattcgaaa tgagtcccat gactatcctc atagagtggc caagtttcca      120

gaaaacagaa atcgaaacag atacagagat gtaagcccat atgatcacag tcgtgttaaa      180

ctgcaaaatg ctgagaatga ttatattaat gccagtttag ttgacataga agaggcacaa      240

aggagttaca tcttaacaca gggtccactt cctaacacat gctgccattt ctggcttatg      300

gtttggcagc agaagaccaa agcagttgtc atgctgaacc gcattgtgga gaaagaatcg      360

gttaaatgtg cacagtactg gccaacagat gaccaagaga tgctgtttaa agaaacagga      420

ttcagtgtga agctcttgtc agaagatgtg aagtcgtatt atacagtaca tctactacaa      480

ttagaaaata tcaatagtgg tgaaaccaga acaatatctc actttcatta tactacctgg      540

ccagattttg gagtccctga atcaccagct tcatttctca atttcttgtt taaagtgaga      600

gaatctggct ccttgaaccc tgaccatggg cctgcggtga tccactgtag tgcaggcatt      660

gggcgctctg gcaccttctc tctggtagac acttgtcttg ttttgatgga aaaaggagat      720

gatattaaca taaaacaagt gttactgaac atgagaaaat accgaatggg tcttattcag      780

accccagatc aactgagatt ctcatacatg gctataatag aaggagcaaa atgtataaag      840

ggagattcta gtatacagaa acgatggaaa gaactttcta aggaagactt atctcctgcc      900

tttgatcatt caccaaacaa aataatgact gaaaaataca atgggaacag aataggtcta      960

gaagaagaaa aactgacagg tgaccgatgt acaggacttt cctctaaaat gcaagataca     1020

atggaggaga acagtgagag tgctctacgg aaacgtattc gagaggacag aaaggccacc     1080

acagctcaga aggtgcagca gatgaaacag aggctaaatg agaatgaacg aaaaagaaaa     1140

aggtggttat attggcaacc tattctcact aagatggggt ttatgtcagt cattttggtt     1200

ggcgcttttg ttggctggac actgtttttt cagcaaaatg ccctataa                  1248


<210>  129
<211>  1446
<212>  DNA
<213>  Homo sapiens

<400>  129
atggcttata atgacacaga cagaaaccag actgagaagc tcctaaaaag agtacgagaa       60

ctggagcaag aggtgcaaag acttaaaaag gaacaggcca aaaataagga ggactcaaac      120

attagagaaa attcagcagg agctggaaaa actaagcgtg catttgattt cagtgctcat      180

ggccgaagac acgtagccct aagaatagcc tatatgggct ggggatacca gggctttgct      240

agtcaggaaa acacaaataa taccattgaa gagaaactgt ttgaagctct aaccaagact      300

cgactagtag aaagcagaca gacatccaac tatcaccgat gtgggagaac agataaagga      360

gttagtgcct ttggacaggt gatctcactt gaccttcgct ctcagtttcc aaggggcagg      420

gattccgagg actttaatgt aaaagaggag gctaatgctg ctgctgaaga gatccgttat      480

acccacattc tcaatcgggt actccctcca gacatccgta tattggcctg ggcccctgta      540

gaaccaagct tcagtgctag gttcagctgc cttgagcgga cttaccgcta ttttttccct      600

cgtgctgatt tagatattgt aaccatggat tatgcagctc agaagtatgt tggcacccat      660

gatttcagga acttgtgtaa aatggatgta gccaacggtg tgattaattt tcagaggact      720

attctatctg ctcaagtaca gctagtgggc cagagcccag gtgaggggag atggcaagaa      780

cctttccagt tatgtcagtt tgaagtgact ggccaggcat tcctttatca tcaagtccga      840

tgtatgatgg ctatcctctt tctgattggc caaggaatgg agaagccaga gattattgat      900

gagctgctga atatagagaa aaatccccaa aagcctcaat atagtatggc tgtagaattt      960

cctctagtct tatatgactg taagtttgaa aatgtcaagt ggatctatga ccaggaggct     1020

caggagttca atattaccca cctacaacaa ctgtgggcta atcatgctgt caaaactcac     1080

atgttgtata gtatgctaca aggactggac actgttccag taccctgtgg aataggacca     1140

aagatggatg gaatgacaga atggggaaat gttaagccct ctgtcataaa gcagaccagt     1200

gcctttgtag aaggagtgaa gatgcgcaca tataagcccc tcatggaccg tcctaaatgc     1260

caaggactgg aatcccggat ccagcatttt gtacgtaggg gacgaattga gcacccacat     1320

ttattccatg aggaagaaac aaaagccaaa agggactgta atgacacact agaggaagag     1380

aatactaatt tggagacacc aacgaagagg gtctgtgttg acacagaaat taaaagcatc     1440

atttaa                                                                1446


<210>  130
<211>  1950
<212>  DNA
<213>  Homo sapiens

<400>  130
atgtccctaa tggtctcggc tggccggggc ctgggggccg tgtggtcccc aacccacgtg       60

caggtgacgg tgctgcaggc gcggggcctg cgggccaagg gccccggggg cacgagcgac      120

gcgtacgcgg tgatccaggt gggcaaggag aagtacgcca cctccgtgtc ggagcgcagc      180

ctgggcgcgc ccgtgtggcg cgaggaggcc accttcgagc tgccatcgct gctgtcctcc      240

ggacccgcgg ccgccgccac cctgcagctc accgtgctgc accgcgcgct gctcggcctc      300

gacaagttcc tgggccgcgc cgaggtggac ctgcgggatc tgcaccgcga ccagggccgc      360

aggaagacgc agtggtataa gttgaaatcc aaaccaggaa agaaggacaa ggagcgagga      420

gaaattgagg ttgacatcca gtttatgaga aacaacatga ctgccagcat gtttgacctt      480

tctatgaaag acaagtctcg gaatccattt ggaaagctga aggacaagat caaggggaag      540

aataaggaca gtgggtcaga caccgcctcc gccatcatcc ctagcacgac accttcggtc      600

gacagtgatg atgagtctgt ggttaaagac aagaaaaaga aatcaaagat caagacctta      660

ctttccaagt caaatttgca gaagacgcct ctttcccagt ccatgtctgt cctgccgact      720

tcaaagccag aaaaagtgct gcttcgtccc ggagactttc agtcccagtg ggatgaagat      780

gacaatgagg atgagtcctc ctcggcctcg gatgtcatgt ctcacaagag aacagcgagt      840

acggatctta agcaactgaa ccaggtcaac tttacccttc ccaagaagga aggactttcc      900

tttcttggtg gccttcggtc taagaatgat gtcctttccc gctctaatgt ctgcatcaat      960

gggaaccatg tttacctgga gcagccagaa gccaagggtg agatcaagga tagcagcccg     1020

tcctcctccc catcccccaa gggcttcaga aagaagcatt tgttctcttc tacagagaac     1080

ctggcggctg ggtcttggaa ggagcctgct gaaggaggtg ggctgtcttc tgacaggcag     1140

ctctccgaat cttccaccaa ggactccttg aagtctatga ccctgccgtc ctaccgacct     1200

gccccactgg tcagtgggga cctcagggaa aacatggccc ccgcaaactc agaggccaca     1260

aaagaagcta aggagagcaa gaagccagag agcaggaggt cctctttgct gtctctgatg     1320

acggggaaga aggatgtggc taagggcagt gaaggtgaaa accctctcac ggtcccaggg     1380

agggagaagg aaggcatgct gatgggggtt aagccggggg aggacgcatc ggggcctgct     1440

gaagaccttg tgagaagatc tgagaaagat actgcagctg ttgtctccag acagggcagc     1500

tccctgaacc tctttgaaga tgtgcagatc acagaaccag aagctgagcc agagtccaag     1560

tctgaaccga gacctccaat ttcctctccg agggctcccc agaccagagc tgtcaagccc     1620

cgacttcatc ctgtgaagcc aatgaatgca atggccacca aggttgctaa ctgcagcttg     1680

ggaactgcca ccatcatcag tgagaacttg aacaatgagg tcatgatgaa gaaatacagc     1740

ccctcggacc ctgcatttgc atatgcgcag ctgacccacg atgagctgat tcagctggtc     1800

ctcaaacaga aggaaacgat aagcaagaag gagttccagg tccgcgagct ggaagactac     1860

attgacaacc tgcttgtcag ggtcatggaa gaaaccccca atatcctccg catcccgact     1920

caggttggca aaaaagcagg aaagatgtaa                                      1950


<210>  131
<211>  2271
<212>  DNA
<213>  Homo sapiens

<400>  131
atggcgtcgg ccccgccggc ctcgcccccg ggctcggagc cgccggggcc cgacccggag       60

ccgggcgggc cggacgggcc gggggcggca caactggctc cgggccctgc ggagctacgc      120

ctcggagcgc ccgtcggcgg ccccgacccg cagtccccgg gcctggatga gcctgcgccc      180

ggggccgctg cagatggcgg ggcgcgttgg agcgccgggc cggccccggg gctggaggga      240

ggcccgcgag accccgggcc gtccgccccg ccgccgcgct ccggcccgcg ggggcagctt      300

gcgagccccg acgccccggg cccagggccg cgctccgaag cgccgcttcc agaactcgac      360

ccgttgttct cctggactga ggagcccgag gagtgtggcc ccgcgagctg cccggagagc      420

gcgcctttcc gcttgcaggg gtccagcagc agccaccgag cgcggggcga ggtcgacgtc      480

ttctctccct tccccgcgcc cacggcgggc gagctggcgc tggagcaagg tcccgggtcc      540

ccgccgcagc cctcggacct cagccagacc cacccccttc cgagcgagcc cgtggggagt      600

caggaggacg gcccccgcct ccgagccgtg ttcgatgccc tggacgggga tggggacggt      660

ttcgtccgca tcgaggactt catccagttt gctacggtct acggggcaga gcaggtgaag      720

gacttaacta agtacttgga tcccagtggg ctcggcgtga tcagctttga agacttctac      780

caagggatca cagccatcag aaacggagat cctgatggcc agtgctacgg tggtgtcgct      840

tctgcccaag atgaggagcc cctggcctgc ccggacgagt tcgatgactt cgtcacctat      900

gaggccaacg aggtgacgga cagcgcgtac atgggctccg agagcaccta cagtgagtgt      960

gagaccttca cggacgagga caccagcacc ctggtgcacc ctgagctgca acctgaaggg     1020

gacgcagaca gtgccggcgg ctcggccgtg ccctctgagt gcctggacgc catggaggag     1080

cccgaccatg gtgccctgct gctgctccca ggcaggcctc acccccatgg ccagtctgtc     1140

atcacggtga tcgggggcga ggagcacttt gaggactacg gtgaaggcag tgaggcggag     1200

ctgtccccag agaccctatg caacgggcag ctgggctgca gtgaccccgc tttcctcacg     1260

cccagtccga caaagcggct ctccagcaag aaggtggcaa ggtacctgca ccagtcaggg     1320

gccctgacca tggaggccct ggaggaccct tcccccgagc tcatggaggg cccagaggag     1380

gacattgctg acaaggttgt cttcctggaa aggcgtgtgc tggagctgga aaaggacacg     1440

gcagccaccg gtgagcaaca cagccgcctg aggcaggaga acctgcagct ggtgcacaga     1500

gcaaacgccc tggaggagca gctgaaggag caggagctga gagcctgcga gatggtcctg     1560

gaagagaccc ggcgtcagaa ggagctcctg tgcaagatgg agagggagaa gagcattgag     1620

atcgagaacc tgcagaccag gctacagcaa ctggacgagg agaacagtga actccggtcc     1680

tgcacgccct gtctgaaggc caacattgag cgtctggagg aggagaagca gaagctgttg     1740

gatgagatag agtcgctgac gctgcggctc agtgaagagc aggagaacaa gaggagaatg     1800

ggggacaggc tgagtcacga gaggcaccag ttccagaggg acaaggaggc cacccaggag     1860

ctgatcgagg acctccgaaa gcagctggag cacctgcagc tcctcaagct ggaggccgag     1920

cagcggcggg gccgcagcag cagcatgggc ctgcaggagt accacagccg cgcccgggag     1980

agcgagctgg agcaggaggt ccgcaggctg aagcaggaca accgcaacct gaaggagcag     2040

aacgaggagc tgaacgggca gatcattacc ctcagcatcc agggcgccaa gagcctcttc     2100

tccacagcct tctctgagtc cctggctgca gagatcagct ccgtctcccg agatgagctc     2160

atggaggcga ttcagaagca ggaggagatc aacttccgcc tgcaggacta catcgacagg     2220

atcatcgtgg ccatcatgga gaccaacccg tccatcctgg aggtcaagta g              2271


<210>  132
<211>  606
<212>  DNA
<213>  Homo sapiens

<400>  132
atggcaggaa aatcatcact ttttaaagta attctccttg gagatggtgg agttgggaag       60

agttcactta tgaacagata tgtaactaat aagtttgata cccagctctt ccatacaata      120

ggtgtggaat ttttaaataa agatttggaa gtggatggac attttgttac catgcagatt      180

tgggacacgg caggtcagga gcgattccga agcctgagga caccatttta cagaggttct      240

gactgctgcc tgcttacttt tagtgtcgat gattcacaaa gcttccagaa cttaagtaac      300

tggaagaaag aattcatata ttatgcagat gtgaaagagc ctgagagctt tccttttgtg      360

attctgggta acaagattga cataagcgaa cggcaggtgt ctacagaaga agcccaagct      420

tggtgcaggg acaacggcga ctatccttat tttgaaacaa gtgcaaaaga tgccacaaat      480

gtggcagcag cctttgagga agcggttcga agagttcttg ctaccgagga taggtcagat      540

catttgattc agacagacac agtcaatctt caccgaaagc ccaagcctag ctcatcttgc      600

tgttga                                                                 606


<210>  133
<211>  1863
<212>  DNA
<213>  Homo sapiens

<400>  133
atggcggcag cgacggcaga cccgggagct gggaacccgc agcctgggga ctcctccggc       60

gggggcgctg ggggcgggct gccgtcccct ggggagcagg agctgagccg gcgcttgcag      120

cgcctgtatc ccgcggtcaa ccagcaagag actccgctgc cgcgctcctg gagccccaag      180

gacaaataca actacattgg tctctcccag ggcaacctcc gcgtccacta caaaggtcat      240

ggcaaaaatc acaaagatgc ggcctcagtg cgtgccaccc accccatacc tgctgcctgt      300

ggcatttatt actttgaagt gaagattgtc agcaaaggaa gagatggtta catgggaata      360

ggactctcgg ctcaaggcgt caacatgaac agacttcctg gttgggacaa acattcctat      420

ggttaccatg gtgatgatgg gcattcgttc tgctcctcgg ggactggcca gccctatggt      480

cccacattca ccacaggaga cgtgatcggc tgctgtgtca acctcatcaa tggcacctgc      540

ttctacacca agaatggcca cagccttggt atagccttca cagacctccc ggccaacctc      600

taccccaccg taggcctgca gacacctggg gagattgtgg acgccaactt tgggcagcag      660

cccttcctgt ttgacattga ggactacatg cgggagtggc gtgccaaggt ccagggcacg      720

gtccactgct tccccatcag tgcccggctt ggcgagtggc aggcagtgct gcagaacatg      780

gtttcatctt acctcgtgca tcatgggtat tgtgccacag ccacggcttt tgctcgaatg      840

actgaaaccc cgattcagga agaacaggcg tccataaaga acagacaaaa gatccagaag      900

ctggtgctgg agggccgtgt gggcgaggcc atcgagacca cccagcgctt ctacccaggg      960

ctgctggagc acaaccccaa cctcctcttc atgctcaagt gccggcagtt tgtggagatg     1020

gtgaatggga cggacagtga ggtccgaagt ttgagctccc gaagccccaa gtcccaggac     1080

agctaccctg gctcccccag cctcagtccc cgacatggcc ccagtagttc ccacatgcac     1140

aacacaggag cagacagtcc cagctgtagc aatggcgtcg cgtccaccaa gagcaaacag     1200

aaccacagta aataccctgc acccagctcc tcatcctcgt cctcctcctc ctcctcgtcc     1260

tcttccccat cctccgtcaa ttactccgag tccaactcaa cagactccac caagtcccag     1320

caccacagca gtaccagtaa ccaggagacc agcgacagtg agatggagat ggaggcagag     1380

cactacccca acggtgtgct aggaagcatg tccacacgca ttgttaatgg tgcctacaag     1440

catgaggacc tgcagacgga tgagtccagc atggatgaca ggcatcctcg gcggcagctc     1500

tgcgggggca accaggctgc cacagaaagg atcattctgt ttggccgcga gttgcaggca     1560

ttgagtgagc agttgggccg ggagtacggc aagaatttgg cccacacaga gatgctgcag     1620

gatgccttca gcctgctggc atactcagac ccctggagct gcccagttgg ccagcagctt     1680

gaccccatcc agagggaacc tgtgtgtgct gccctcaaca gcgccatttt agagtcccag     1740

aacctgccaa agcagccccc tctgatgctc gccctgggcc aggcatctga gtgtctccgg     1800

ctcatggccc gagcaggcct gggttcttgc tcctttgcca gagttgatga ctacttgcac     1860

tag                                                                   1863


<210>  134
<211>  1830
<212>  DNA
<213>  Homo sapiens

<400>  134
atggcaggca ccctggacct ggacaagggc tgcacggtgg aggagctgct ccgcgggtgc       60

atcgaagcct tcgatgactc cgggaaggtg cgggacccgc agctggtgcg catgttcctc      120

atgatgcacc cctggtacat cccctcctct cagctggcgg ccaagctgct ccacatctac      180

caacaatccc ggaaggacaa ctccaattcc ctgcaggtga aaacgtgcca cctggtcagg      240

tactggatct ccgccttccc agcggagttt gacttgaacc cggagttggc tgagcagatc      300

aaggagctga aggctctgct agaccaagaa gggaaccgac ggcacagcag cctaatcgac      360

atagacagcg tccctaccta caagtggaag cggcaggtga ctcagcggaa ccctgtggga      420

cagaaaaagc gcaagatgtc cctgttgttt gaccacctgg agcccatgga gctggcggag      480

catctcacct acttggagta tcgctccttc tgcaagatcc tgtttcagga ctatcacagt      540

ttcgtgactc atggctgcac tgtggacaac cccgtcctgg agcggttcat ctccctcttc      600

aacagcgtct cacagtgggt gcagctcatg atcctcagca aacccacagc cccgcagcgg      660

gccctggtca tcacacactt tgtccacgtg gcggagaagc tgctacagct gcagaacttc      720

aacacgctga tggcagtggt cgggggcctg agccacagct ccatctcccg cctcaaggag      780

acccacagcc acgttagccc tgagaccatc aagctctggg agggtctcac ggaactagtg      840

acggcgacag gcaactatgg caactaccgg cgtcggctgg cagcctgtgt gggcttccgc      900

ttcccgatcc tgggtgtgca cctcaaggac ctggtggccc tgcagctggc actgcctgac      960

tggctggacc cagcccggac ccggctcaac ggggccaaga tgaagcagct ctttagcatc     1020

ctggaggagc tggccatggt gaccagcctg cggccaccag tacaggccaa ccccgacctg     1080

ctgagcctgc tcacggtgtc tctggatcag tatcagacgg aggatgagct gtaccagctg     1140

tccctgcagc gggagccgcg ctccaagtcc tcgccaacca gccccacgag ttgcacccca     1200

ccaccccggc ccccggtact ggaggagtgg acctcggctg ccaaacccaa gctggatcag     1260

gccctcgtgg tggagcacat cgagaagatg gtggagtctg tgttccggaa ctttgacgtc     1320

gatggggatg gccacatctc acaggaagaa ttccagatca tccgtgggaa cttcccttac     1380

ctcagcgcct ttggggacct cgaccagaac caggatggct gcatcagcag ggaggagatg     1440

gtttcctatt tcctgcgctc cagctctgtg ttgggggggc gcatgggctt cgtacacaac     1500

ttccaggaga gcaactcctt gcgccccgtc gcctgccgcc actgcaaagc cctgatcctg     1560

ggcatctaca agcagggcct caaatgccga gcctgtggag tgaactgcca caagcagtgc     1620

aaggatcgcc tgtcagttga gtgtcggcgc agggcccaga gtgtgagcct ggaggggtct     1680

gcaccctcac cctcacccat gcacagccac catcaccgcg ccttcagctt ctctctgccc     1740

cgccctggca ggcgaggctc caggcctcca gagatccgtg aggaggaggt acagacggtg     1800

gaggatgggg tgtttgacat ccacttgtaa                                      1830


<210>  135
<211>  2070
<212>  DNA
<213>  Homo sapiens

<400>  135
atgggatcaa gtggccttgg gaaagcagca acattagatg aactgctgtg cacttgcatt       60

gagatgtttg atgacaatgg agagctggat aatagttatt tgccaagaat agttctactg      120

atgcaccgat ggtatttatc ttccactgaa ttggcagaaa aacttctctg catgtatcga      180

aatgccactg gagaaagctg caatgaattt cgattaaaga tctgctactt catgaggtac      240

tggattctga agtttcctgc agagtttaat ttggatcttg gtttgattcg tatgactgag      300

gaatttcggg aagtagctag tcaactagga tatgaaaaac acgtcagcct catcgacata      360

tccagcattc cttcctatga ctggatgaga agagtcacac agaggaaaaa agtatccaag      420

aagggaaaag cctgtctgct gtttgaccat ctggagccca ttgaattggc tgagcacctc      480

acttttctgg agcataaatc ttttagaagg atctcattca ctgattacca aagctatgtc      540

atccatggct gcctggagaa taatccaacc ttggaaagat cgattgcttt atttaatgga      600

atctctaagt gggtccagtt gatggttctt agcaaaccaa ccccccagca aagggcagaa      660

gtcatcacaa agtttatcaa tgttgcaaag aagctccttc agctcaaaaa ttttaacacc      720

ctgatggcag tggtgggagg cctcagtcat agttccattt cacgcctcaa agagacccat      780

tctcatcttt cttcagaagt tacaaagaac tggaatgaaa tgacagagtt ggtctcctcc      840

aacggcaatt actgcaatta ccgcaaggcc tttgccgact gcgatggctt caaaatcccc      900

atccttggag tacacttgaa agacttgata gctgtccatg tcattttccc agactggaca      960

gaggagaaca aagtgaacat tgtgaaaatg caccagctct ccgttaccct gagtgaacta     1020

gtctccctgc agaatgcctc tcaccactta gaacccaaca tggatttgat caacctgctc     1080

acgctttccc tggacctcta tcacactgaa gatgatattt acaaactgtc actggtgctg     1140

gagcctagaa attctaaatc gcctacctcc cctacgacgc ccaacaagcc tgtggtaccc     1200

ctggagtggg cattaggggt gatgccaaag ccagacccca cggtcatcaa caagcacata     1260

aggaaattag tggagtctgt atttagaaac tatgatcacg accatgatgg gtacatttcc     1320

caagaggact ttgaaagtat agctgccaat tttcccttct tggattcctt ctgtgttctg     1380

gacaaagatc aggatggcct aattagtaaa gatgaaatga tggcttactt cctgagagct     1440

aaatcccaac tacactgtaa aatgggacca ggatttatcc ataattttca ggagatgacc     1500

tatctcaagc caaccttctg cgaacactgt gcgggatttc tctggggcat aatcaagcaa     1560

ggatacaaat gcaaagactg tggagccaat tgtcacaaac agtgcaaaga cctcctggtt     1620

ctggcctgca ggagatttgc ccgggcgccc tccttgagca gtggtcatgg gtcactgcct     1680

ggaagcccct cgctgccccc agcgcaggat gaggtgtttg agttccctgg agtcactgct     1740

ggacacaggg atttagacag cagagccatc acactggtta caggctcttc tcgcaagatc     1800

tctgtgaggc tacagagggc caccaccagc caggccaccc agactgaacc tgtctggtca     1860

gaggctggct ggggggactc ggggtcccac accttcccta aaatgaaatc caagttccat     1920

gacaaagcag caaaggacaa aggctttgcc aaatgggaaa atgagaagcc cagggtgcat     1980

gctggtgtgg atgttgtaga ccggggcacg gagtttgaac ttgaccagga tgaaggagaa     2040

gagaccagac aggatggtga ggatggctga                                      2070


<210>  136
<211>  1122
<212>  DNA
<213>  Homo sapiens

<400>  136
atgttgttgg gactggcggc catggagctg aaggtgtggg tggatggcat ccagcgtgtg       60

gtctgtgggg tctcagagca gaccacctgc caggaagtgg tcatcgcact agcccaagca      120

ataggccaga ctggccgctt tgtgcttgtg cagcggcttc gggagaagga gcggcagttg      180

ctgccacaag agtgtccagt gggcgcccag gccacctgcg gacagtttgc cagcgatgtc      240

cagtttgtcc tgaggcgcac aggggccagc ctagctggga ggccctcctc agacagctgt      300

ccacccccgg aacgctgcct aattcgtgcc agcctccctg taaagccacg ggctgcgctg      360

ggctgtgagc cccgcaaaac actgaccccc gagccagccc ccagcctctc acgccctggg      420

cctgcggccc ctgtgacacc cacaccaggc tgctgcacag acctgcgggg cctggagctc      480

agggtgcaga ggaatgctga ggagctgggc catgaggcct tctgggagca agagctgcgc      540

cgggagcagg cccgggagcg agagggacag gcacgcctgc aggcactaag tgcggccact      600

gctgagcatg ccgcccggct gcaggccctg gacgctcagg cccgtgccct ggaggctgag      660

ctgcagctgg cagcggaggc ccctgggccc ccctcaccta tggcatctgc cactgagcgc      720

ctgcaccagg acctggctgt tcaggagcgg cagagtgcgg aggtgcaggg cagcctggct      780

ctggtgagcc gggccctgga ggcagcagag cgagccttgc aggctcaggc tcaggagctg      840

gaggagctga accgagagct ccgtcagtgc aacctgcagc agttcatcca gcagaccggg      900

gctgcgctgc caccgccccc acggcctgac aggggccctc ctggcactca gggccctctg      960

cctccagcca gagaggagtc cctcctgggc gctccctctg agtcccatgc tggtgcccag     1020

cctaggcccc gaggtggccc ccatgacgca gaactcctgg aggtagcagc agctcctgcc     1080

ccagagtggt gtcctctggc agcccagccc caggctctgt ga                        1122


<210>  137
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  137
atgccgaaac caatcaacgt aagagtaact acaatggatg ctgagctgga atttgccatt       60

cagcccaata caactggcaa acaacttttt gaccaggtgg tgaaaacagt tggtttgcgt      120

gaggtctggt tttttgggct gcagtatgta gacagcaaag gttattctac atggcttaaa      180

ctaaataaaa aggtaacaca gcaggatgtt aaaaaagaga atcctttaca gttcaagttt      240

agagctaaat tctttcctga agatgtttct gaggaattaa ttcaagaaat aacccagaga      300

ctcttcttct tgcaagttaa agaagccatc ttaaatgatg agatatattg cccgccagaa      360

actgcagttc ttttggcttc ctatgctgtc caagccaagt atggagatta caataaagag      420

attcataagc caggctacct ggctaatgat agactcctac cccagcgtgt attggaacaa      480

cacaaactaa caaaagaaca gtgggaagaa agaatacaga actggcatga agaacataga      540

ggaatgttaa gggaggattc tatgatggaa tacctgaaga ttgcacaaga tctagaaatg      600

tatggagtca actattttga aataaaaaat aaaaaaggaa ctgaattgtg gctaggtgtt      660

gatgctttgg gtctgaatat ttatgagcat gacgacaagt taacacctaa aattggtttt      720

ccctggagtg aaatcagaaa tatttcattt aatgacaaaa aatttgttat aaagccaatc      780

gacaaaaagg cacctgattt tgtgttttat gcacctcgtc tgagaatcaa taagcggatt      840

ttggccttat gtatgggaaa ccatgaacta tacatgcgaa gaaggaagcc tgatactatt      900

gaagtacaac agatgaaggc tcaggctagg gaggagaaac atcagaagca gttggaaagg      960

gcacaattag agaatgaaaa gaagaaaaga gaaatagcag aaaaggaaaa ggaaagaata     1020

gaacgtgaaa aggaagagct aatggaacgt ctaaaacaaa ttgaagagca gacaattaaa     1080

gctcagaaag aactagaaga acagactcga aaagctctag aactggatca agaacgaaaa     1140

cgagcaaaag aagaagcaga acgacttgaa aaggagcgtc gagctgctga agaggcaaag     1200

tctgccatag caaaacaagc tgccgaccag atgaagaatc aggagcagct agcagcagaa     1260

cttgctgaat tcactgccaa gattgcactt ctagaggaag ccaagaagaa aaaggaagag     1320

gaagctactg agtggcaaca caaagctttt gcagcccagg aagacttgga aaagaccaaa     1380

gaagagttaa aaactgtgat gtctgccccc cctccacctc caccaccacc agtcattcct     1440

ccaacagaaa acgaacatga tgaacacgat gagaataatg ctgaagctag tgctgaatta     1500

tcaaatgaag gggtaatgaa ccatagaagc gaggaagaac gtgtaaccga aacacagaaa     1560

aatgagcgtg ttaagaagca acttcaggca ttaagttcag aattagccca agccagagat     1620

gaaaccaaga aaacacaaaa tgatgttctt catgctgaga atgttaaagc aggccgtgat     1680

aagtacaaga ctctgcgaca gattcgacaa ggcaatacaa agcagcgtat cgatgagttt     1740

gaagcaatgt ga                                                         1752


<210>  138
<211>  453
<212>  DNA
<213>  Homo sapiens

<400>  138
atggtgctat gctttcctct tcttttactg ctgctggttc tatggggacc agtgtgtcca       60

cttcatgctt ggcctaagcg tctcaccaag gctcactggt ttgaaattca gcatatacag      120

ccaagtcctc tccaatgcaa cagggcaatg agtggcatca acaattatac ccagcactgt      180

aagcatcaaa atacctttct gcatgactct ttccagaatg tggctgctgt ctgtgatttg      240

ctcagcattg tctgcaaaaa tcgtcggcac aactgccacc agagctcaaa gcctgtcaac      300

atgactgact gcagactcac ttcaggaaag tatccccagt gccgctatag tgctgctgcc      360

cagtacaaat tcttcattgt tgcctgtgac ccccctcaga agagcgatcc cccctacaag      420

ttggttcctg tacacttaga tagtattctc taa                                   453


<210>  139
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  139
atgaaggcgg gtgccacgtc tatgtgggct tcgtgctgtg ggctgctgaa tgaagtcatg       60

ggaactggag ctgtcagggg ccagcagtca gcatttgcag gagccaccgg tccattcaga      120

tttacaccaa accctgagtt ttccacctac ccaccagcag ctacggaagg gcccaacata      180

gtttgtaaag cctgtgggct ttcattttca gtctttagaa agaagcatgt ttgctgtgac      240

tgcaagaagg atttttgctc cgtttgttca gtcttacaag aaaatctccg tagatgttct      300

acttgtcact tattacaaga gacagcattt cagcgccctc agttaatgcg actgaaggtg      360

aaggacctgc ggcagtatct cattctgaga aatataccca tagatacttg tcgtgagaaa      420

gaagacttgg tggatctagt actgtgccat catggactag gctctgagga cgacatggac      480

acaagcagtc tgaattcttc aaggtcccag acttctagct tttttacacg ttcgtttttt      540

tcaaactata cagccccctc tgctactatg tcttcgtttc agggagagct tatggatgga      600

gaccaaacat ccagatctgg agtgccggca caggtacaaa gtgaaatcac ttcagcaaac      660

acagaagatg atgatgacga cgatgatgag gatgatgatg atgaagaaga aaacgcagag      720

gatcggaacc ccgggctctc caaggagaga gtgagagctt cactgtctga cttgtcaagc      780

cttgatgatg tggaaggaat gagcgtgcgc cagctgaagg aaattctggc tcggaatttt      840

gtcaactatt ctggctgttg tgaaaaatgg gaactggtag agaaagtaaa ccggttatac      900

aaagagaatg aagaaaacca aaagtcctat ggcgagcggc tgcagctgca ggatgaggaa      960

gacgacagcc tgtgtcgcat ctgcatggat gccgtcatcg actgtgtcct actggagtgt     1020

gggcacatgg ttacctgcac caagtgcggc aagcgcatga gtgagtgtcc catctgccgg     1080

cagtatgtgg tgcgagccgt gcacgtgttc aagtcctga                            1119


<210>  140
<211>  813
<212>  DNA
<213>  Homo sapiens

<400>  140
atgtggaaca gtggattcga aagctatggc agctcctcat acgggggagc cggcggctac       60

acgcagtccc cggggggctt tggatcgccc gcaccttctc aagccgaaaa gaaatcaaga      120

gcccgagccc agcacattgt gccctgtact atatctcagc tgctttctgc cactttggtt      180

gatgaagtgt tcagaattgg gaatgttgag atttcacagg tcactattgt ggggatcatc      240

agacatgcag agaaggctcc aaccaacatt gtttacaaaa tagatgacat gacagctgca      300

cccatggacg ttcgccagtg ggttgacaca gatgacacca gcagtgaaaa cactgtggtt      360

cctccagaaa catatgtgaa agtggcaggc cacctgagat cttttcagaa caaaaagagc      420

ctggtagcct ttaagatcat gcccctggag gatatgaatg agttcaccac acatattctg      480

gaagtgatca atgcacacat ggtactaagc aaagccaaca gccagccctc agcagggaga      540

gcacctatca gcaatccagg aatgagtgaa gcagggaact ttggtgggaa tagcttcatg      600

ccagcaaatg gcctcactgt ggcccaaaac caggtgttga atttgattaa ggcttgtcca      660

agacctgaag ggttgaactt tcaggatctc aagaaccagc tgaaacacat gtctgtatcc      720

tcaatcaagc aagctgtgga ttttctgagc aatgaggggc acatctattc tactgtggat      780

gatgaccatt ttaaatccac agatgcagaa taa                                   813


<210>  141
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  141
atggcggccg tgtttgattt ggatttggag acggaggaag gcagcgaggg cgagggcgag       60

ccagagctca gccccgcgga cgcatgtccc cttgccgagt tgagggcagc tggcctagag      120

cctgtgggac actatgaaga ggtggagctg actgagacca gcgtgaacgt tggcccagag      180

cgcatcgggc cccactgctt tgagctgctg cgtgtgctgg gcaagggggg ctatggcaag      240

gtgttccagg tgcgaaaggt gcaaggcacc aacttgggca aaatatatgc catgaaagtc      300

ctaaggaagg ccaaaattgt gcgcaatgcc aaggacacag cacacacacg ggctgagcgg      360

aacattctag agtcagtgaa gcaccccttt attgtggaac tggcctatgc cttccagact      420

ggtggcaaac tctacctcat ccttgagtgc ctcagtggtg gcgagctctt cacgcatctg      480

gagcgagagg gcatcttcct ggaagatacg gcctgcttct acctggctga gatcacgctg      540

gccctgggcc atctccactc ccagggcatc atctaccggg acctcaagcc cgagaacatc      600

atgctcagca gccagggcca catcaaactg accgactttg gactctgcaa ggagtctatc      660

catgagggcg ccgtcactca caccttctgc ggcaccattg agtacatggc ccctgagatt      720

ctggtgcgca gtggccacaa ccgggctgtg gactggtgga gcctgggggc cctgatgtac      780

gacatgctca ctggatcgcc gcccttcacc gcagagaacc ggaagaaaac catggataag      840

atcatcaggg gcaagctggc actgcccccc tacctcaccc cagatgcccg ggaccttgtc      900

aaaaagtttc tgaaacggaa tcccagccag cggattgggg gtggcccagg ggatgctgct      960

gatgtgcaga gacatccctt tttccggcac atgaattggg acgaccttct ggcctggcgt     1020

gtggaccccc ctttcaggcc ctgtctgcag tcagaggagg acgtgagcca gtttgatacc     1080

cgcttcacac ggcagacgcc ggtggacagt cctgatgaca cagccctcag cgagagtgcc     1140

aaccaggcct tcctgggctt cacatacgtg gcgccgtctg tcctggacag catcaaggag     1200

ggcttctcct tccagcccaa gctgcgctca cccaggcgcc tcaacagtag cccccgggcc     1260

cccgtcagcc ccctcaagtt ctcccctttt gaggggtttc ggcccagccc cagcctgccg     1320

gagcccacgg agctacctct acctccactc ctgccaccgc cgccgccctc gaccaccgcc     1380

cctctcccca tccgtccccc ctcagggacc aagaagtcca agaggggccg tgggcgtcca     1440

gggcgctag                                                             1449


<210>  142
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  142
atgggcatct ctcgggacaa ctggcacaag cgccgcaaaa ccgggggcaa gagaaagccc       60

taccacaaga agcggaagta tgagttgggg cgcccagctg ccaacaccaa gattggcccc      120

cgccgcatcc acacagtccg tgtgcgggga ggtaacaaga aataccgtgc cctgaggttg      180

gacgtgggga atttctcctg gggctcagag tgttgtactc gtaaaacaag gatcatcgat      240

gttgtctaca atgcatctaa taacgagctg gttcgtacca agaccctggt gaagaattgc      300

atcgtgctca tcgacagcac accgtaccga cagtggtacg agtcccacta tgcgctgccc      360

ctgggccgca agaagggagc caagctgact cctgaggaag aagagatttt aaacaaaaaa      420

cgatctaaaa aaattcagaa gaaatatgat gaaaggaaaa agaatgccaa aatcagcagt      480

ctcctggagg agcagttcca gcagggcaag cttcttgcgt gcatcgcttc aaggccggga      540

cagtgtggcc gagcagatgg ctatgtgcta gagggcaaag agttggagtt ctatcttagg      600

aaaatcaagg cccgcaaagg caaataa                                          627


<210>  143
<211>  279
<212>  DNA
<213>  Homo sapiens

<400>  143
atgacaaaac ttgaagagca tctggaggga attgtcaata tcttccacca atactcagtt       60

cggaaggggc attttgacac cctctctaag ggtgagctga agcagctgct tacaaaggag      120

cttgcaaaca ccatcaagaa tatcaaagat aaagctgtca ttgatgaaat attccaaggc      180

ctggatgcta atcaagatga acaggtcgac tttcaagaat tcatatccct ggtagccatt      240

gcgctgaagg ctgcccatta ccacacccac aaagagtag                             279


<210>  144
<211>  288
<212>  DNA
<213>  Homo sapiens

<400>  144
atgacggaac tagagacagc catgggcatg atcatagacg tcttttcccg atattcgggc       60

agcgagggca gcacgcagac cctgaccaag ggggagctca aggtgctgat ggagaaggag      120

ctaccaggct tcctgcagag tggaaaagac aaggatgccg tggataaatt gctcaaggac      180

ctggacgcca atggagatgc ccaggtggac ttcagtgagt tcatagtgtt cgtggctgca      240

atcacgtctg cctgtcacaa gtactttgag aaggcaggac tcaaatga                   288


<210>  145
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  145
atgctgcgcc gcaagccctc caatgccagt gagaaggagc ccactcagaa gaaaaagctc       60

tcccttcagc gctccagcag cttcaaggat tttgccaaat ccaaacccag ctcccccgtg      120

gtgagcgaga aggagtttaa tctggatgat aacattccag aagatgactc aggtgtcccc      180

accccagaag atgctgggaa gagtggcaaa aagctgggga agaagtggag ggcagtgatt      240

tcccgaacca tgaacaggaa gatgggcaag atgatggtga aggccctgtc agaagagatg      300

gcagacactc tggaggaggg ctctgcctcc ccgacatctc cagactacag cctggacagc      360

cctggccctg agaagatggc gctggccttt tctgagcaag aggagcatga acttccggtg      420

ctcagccgcc aggcatcaac aggcagtgag ctctgcagcc ccagcccagg ttctggcagc      480

ttcggggagg aaccacctgc cccccagtac acagggcctt tctgtggccg ggcacgagtc      540

cacaccgact tcactcccag cccctatgac cacgactcgc tgaaactgca gaaaggagat      600

gtgatccaga tcattgaaaa gccacctgtg ggcacgtggc tgggcctact caatggcaag      660

gtgggctctt tcaaattcat ctatgtggat gtgctgcccg aggaggccgt ggggcatgcc      720

cgccccagcc gccgacagag caagggcaag aggcccaagc ctaagaccct gcatgagctg      780

ctggagcgca tcggcctgga ggagcacaca tccaccctcc tgctcaatgg ctaccagaca      840

ctggaagact tcaaagagct gcgagaaaca cacctcaatg agctgaacat catggatcca      900

cagcaccggg ccaagctgct cacggccgcc gagctgctgc tggactatga cactggcagt      960

gaggaggctg aagagggcgc cgagagcagc caggagccag tggcacacac agtgtcggaa     1020

cccaaggtgg acatcccgcg cgactcaggc tgctttgagg gctcggagag cgggcgcgat     1080

gacgcagagc tggcaggcac tgaggagcag ctgcaaggcc tctccctggc cggggcacct     1140

tga                                                                   1143


<210>  146
<211>  5682
<212>  DNA
<213>  Homo sapiens

<400>  146
atggcgcggc tcgcggacta cttcgtgctg gtggcgttcg ggccgcaccc gcgcgggagt       60

ggggaaggcc agggccagat tctgcagcgc ttcccagaga aggactggga ggacaaccca      120

ttcccccagg gcatcgagct gttttgccag cccagcgggt ggcagctgtg tcccgagagg      180

aatccaccga ccttctttgt tgctgtcctc accgacatca actccgagcg ccactactgc      240

gcctgcttga ccttctggga gccagcggag ccttcacagg aaacgacgcg cgtggaggat      300

gccacagaga gggaggaaga gggggatgag ggaggccaga cccacctgtc tcccacagca      360

cctgccccat ctgcccagct gtttgcaccg aagacgctgg tactggtgtc gcgactcgac      420

cacacggagg tgttcaggaa cagccttggc ctcatctatg ccatccacgt ggagggcctg      480

aatgtgtgcc tggagaacgt gattgggaac ctgctgacgt gcactgtgcc cctggctggg      540

ggctcgcaga ggacgatctc tttgggggct ggtgaccggc aggtcatcca gactccactg      600

gccgactcgc tgcccgtcag ccgctgcagc gtggccctgc tcttccgcca gctaggcatc      660

accaacgtgc tgtctttgtt ctgtgccgcc ctcacggagc acaaggttct cttcctgtcc      720

cggagctacc agcggctcgc cgatgcctgt aggggcctcc tggcactgct gtttcctctc      780

agatacagct tcacctatgt gcccatcctg ccggctcagc tgctggaggt cctcagcaca      840

cccacgccct tcatcattgg ggtcaacgcg gccttccagg cagagaccca ggagctgctc      900

gatgtgattg ttgctgatct ggatggaggg acggtcacca ttcctgagtg tgtgcacatt      960

ccacccttgc cagagccact gcagagtcag acgcacagtg tgctgagcat ggtcctggac     1020

ccggagctgg agttggctga cctcgccttc cctccgccca cgacatccac ctcctccctg     1080

aagatgcagg acaaggagct gcgcgcggtc ttcctgcggc tgttcgctca gctgctgcag     1140

ggctatcgct ggtgcctgca cgtcgtgcgc atccacccgg agcctgtcat ccgcttccat     1200

aaggcagcct tcctgggcca gcgtgggctg gtagaggacg atttcctgat gaaggtgctg     1260

gagggcatgg cctttgctgg ctttgtgtca gagcgtgggg tcccataccg ccctacggac     1320

ctgttcgatg agctggtggc ccacgaggtg gcaaggatgc gggcggatga gaaccacccc     1380

cagcgtgtcc tgcgtcacgt ccaggaactg gcagagcagc tctacaagaa cgagaacccg     1440

tacccagccg tggcgatgca caaggtacag aggcccggtg agagcagcca cctgcgacgg     1500

gtgccccgac ccttcccccg gctggatgag ggcaccgtgc agtggatcgt ggaccaggct     1560

gcagccaaga tgcagggtgc acccccagct gtgaaggccg agaggaggac caccgtgccc     1620

tcagggcccc ccatgactgc catactggag cggtgcagtg ggctgcatgt caacagcgcc     1680

cggcggctgg aggttgtgcg caactgcatc tcctacgtgt ttgaggggaa aatgcttgag     1740

gccaagaagc tgctcccagc cgtgttgagg gccctgaagg ggcgagctgc ccgccgctgc     1800

ctcgcccagg agctgcacct gcatgtgcag cagaaccgtg cggtcctgga ccaccagcag     1860

tttgactttg tcgtccgtat gatgaactgc tgcctgcagg actgcacttc tctggacgag     1920

catggcattg cggcggctct gctgcctctg gtcacagcct tctgccggaa gctgagcccg     1980

ggggtgacgc agtttgcata cagctgtgtg caggagcacg tggtgtggag cacgccacag     2040

ttctgggagg ccatgttcta tggggatgtg cagactcaca tccgggccct ctacctggag     2100

cccacggagg acctggcccc cgcccaggag gttggggagg caccttccca ggaggacgag     2160

cgctctgccc tagacgtggc ttctgagcag cggcgcttgt ggccaactct gagtcgtgag     2220

aagcagcagg agctggtgca gaaggaggag agcacggtgt tcagccaggc catccactat     2280

gccaaccgca tgagctacct cctcctgccc ctggacagca gcaagagccg cctacttcgg     2340

gagcgtgccg ggctgggcga cctggagagc gccagcaaca gcctggtcac caacagcatg     2400

gctggcagtg tggccgagag ctatgacacg gagagcggct tcgaggatgc agagacctgc     2460

gacgtagctg gggctgtggt ccgcttcatc aaccgctttg tggacaaggt ctgcacggag     2520

agtggggtca ccagcgacca cctcaagggg ctgcatgtca tggtgccaga cattgtccag     2580

atgcacatcg agaccctgga ggccgtgcag cgggagagcc ggaggctgcc gcccatccag     2640

aagcccaagc tgctgcggcc gcgcctgctg ccgggtgagg agtgtgtgct ggacggcctg     2700

cgcgtctacc tgctgccgga tgggcgtgag gagggcgcgg ggggcagtgc tgggggacca     2760

gcattgctcc cagctgaggg cgccgtcttc ctcaccacgt accgggtcat cttcacgggg     2820

atgcccacgg accccctggt tggggagcag gtggtggtcc gctccttccc ggtggctgcg     2880

ctgaccaagg agaagcgcat cagcgtccag acccctgtgg accagctcct gcaggacggg     2940

ctccagctgc gctcctgcac attccagctg ctgaaaatgg cctttgacga ggaggtgggg     3000

tctgacagcg ccgagctctt ccgtaagcag ctgcataagc tgcggtaccc gccggacatc     3060

agggccacct ttgcgttcac cttgggctct gcccacacac ctggccggcc accgcgagtc     3120

accaaggaca agggtccttc cctcagaacc ctgtcccgga acctggtcaa gaacgccaag     3180

aagaccatcg ggcggcagca tgtcactcgc aagaagtaca acccccccag ctgggagcac     3240

cggggccagc cgccccctga ggaccaggag gacgagatct cagtgtcgga ggagctggag     3300

cccagcacgc tgaccccgtc ctcagccctg aagccctccg accgcatgac catgagcagc     3360

ctggtggaaa gggcttgctg tcgcgactac cagcgcctcg gtctgggcac cctgagcagc     3420

agcctgagcc gggccaagtc tgagcccttc cgcatttctc cggtcaaccg catgtatgcc     3480

atctgccgca gctacccagg gctgctgatc gtgccccaga gtgtccagga caacgccctg     3540

cagcgcgtgt cccgctgcta ccgccagaac cgcttccccg tggtctgctg gcgcagcggg     3600

cggtccaagg cggtgctgct gcgctctgga ggcctgcatg gcaaaggtgt cgtcggcctc     3660

ttcaaggccc agaacgcacc ttctccaggc cagtcccagg cggactcgag tagcctggag     3720

caggagaagt acctgcaggc tgtggtcagc tccatgcccc gctacgccga cgcgtcggga     3780

cgcaacacgc ttagcggctt ctcctcagcc cacatgggca gtcacgttcc cagccccaga     3840

gccagggtca ccacgctgtc caaccccatg gcggcctcgg cctccagacg gaccgcaccc     3900

cgaggtaagt ggggcagtgt ccggaccagt ggacgcagca gtggccttgg caccgatgtg     3960

ggctcccggc tagctggcag agacgcgctg gccccacccc aggccaacgg gggccctccc     4020

gacccgggct tcctgcgtcc gcagcgagca gccctctata tccttgggga caaagcccag     4080

ctcaagggtg tgcggtcaga ccccctgcag cagtgggagc tggtgcccat tgaggtattc     4140

gaggcacggc aggtgaaggc tagcttcaag aagctgctga aagcatgtgt cccaggctgc     4200

cccgctgctg agcccagccc agcctccttc ctgcgctcac tggaggactc agagtggctg     4260

atccagatcc acaagctgct gcaggtgtct gtgctggtgg tggagctcct ggattcaggc     4320

tcctccgtgc tggtgggcct ggaggatggc tgggacatca ccacccaggt ggtatccttg     4380

gtgcagctgc tctcagaccc cttctaccgc acgctggagg gctttcgcct gctggtggag     4440

aaggagtggc tgtccttcgg ccatcgcttc agccaccgtg gagctcacac cctggccggg     4500

cagagcagcg gcttcacacc cgtcttcctg cagttcctgg actgcgtaca ccaggtccac     4560

ctgcagttcc ccatggagtt tgagttcagc cagttctacc tcaagttcct cggctaccac     4620

catgtgtccc gccgtttccg gaccttcctg ctcgactctg actatgagcg cattgagctg     4680

gggctgctgt atgaggagaa gggggaacgc aggggccagg tgccgtgcag gtctgtgtgg     4740

gagtatgtgg accggctgag caagaggacg cctgtgttcc acaattacat gtatgcgccc     4800

gaggacgcag aggtcctgcg gccctacagc aacgtgtcca acctgaaggt gtgggacttc     4860

tacactgagg agacgctggc cgagggccct ccctatgact gggaactggc ccaggggccc     4920

cctgaacccc cagaggaaga acggtctgat ggaggcgctc cccagagcag gcgccgcgtg     4980

gtgtggccct gttacgacag ctgcccgcgg gcccagcctg acgccatctc acgcctgctg     5040

gaggagctgc agaggctgga gacagagttg ggccaacccg ctgagcgctg gaaggacacc     5100

tgggaccggg tgaaggctgc acagcgcctc gagggccggc cagacggccg tggcacccct     5160

agctccctcc ttgtgtccac cgcaccccac caccgtcgct cgctgggtgt gtacctgcag     5220

gaggggcccg tgggctccac cctgagcctc agcctggaca gcgaccagag tagtggctca     5280

accacatccg gctcccgtca ggctgcccgc cgcagcacca gcaccctgta cagccagttc     5340

cagacagcag agagtgagaa caggtcctac gagggcactc tgtacaagaa gggggccttc     5400

atgaagcctt ggaaggcccg ctggttcgtg ctggacaaga ccaagcacca gctgcgctac     5460

tacgaccacc gtgtggacac agagtgcaag ggtgtcatcg acttggcgga ggtggaggct     5520

gtggcacctg gcacgcccac tatgggtgcc cctaagactg tggacgagaa ggccttcttt     5580

gacgtgaaga caacgcgtcg cgtttacaac ttctgtgccc aggacgtgcc ctcggcccag     5640

cagtgggtgg accggatcca gagctgcctg tcggacgcct ga                        5682


<210>  147
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  147
atgtggagcg cgggccgcgg cggggctgcc tggccggtgc tgttggggct gctgctggcg       60

ctgttagtgc cgggcggtgg tgccgccaag accggtgcgg agctcgtgac ctgcgggtcg      120

gtgctgaagc tgctcaatac gcaccaccgc gtgcggctgc actcgcacga catcaaatac      180

ggatccggca gcggccagca atcggtgacc ggcgtagagg cgtcggacga cgccaatagc      240

tactggcgga tccgcggcgg ctcggagggc gggtgcccgc gcgggtcccc ggtgcgctgc      300

gggcaggcgg tgaggctcac gcatgtgctt acgggcaaga acctgcacac gcaccacttc      360

ccgtcgccgc tgtccaacaa ccaggaggtg agtgcctttg gggaagacgg cgagggcgac      420

gacctggacc tatggacagt gcgctgctct ggacagcact gggagcgtga ggctgctgtg      480

cgcttccagc atgtgggcac ctctgtgttc ctgtcagtca cgggtgagca gtatggaagc      540

cccatccgtg ggcagcatga ggtccacggc atgcccagtg ccaacacgca caatacgtgg      600

aaggccatgg aaggcatctt catcaagcct agtgtggagc cctctgcagg tcacgatgaa      660

ctctga                                                                 666


<210>  148
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  148
atggctgcgc tgttgctgag acacgttggt cgtcattgcc tccgagccca ctttagccct       60

cagctctgta tcagaaatgc tgttcctttg ggaaccacgg ccaaagaaga gatggagcgg      120

ttctggaata agaatatagg ttcaaaccgt cctctgtctc cccacattac tatctacagt      180

tggtctcttc ccatggcgat gtccatctgc caccgtggca ctggtattgc tttgagtgca      240

ggggtctctc tttttggcat gtcggccctg ttactccctg ggaactttga gtcttatttg      300

gaacttgtga agtccctgtg tctggggcca gcactgatcc acacagctaa gtttgcactt      360

gtcttccctc tcatgtatca tacctggaat gggatccgac acttgatgtg ggacctagga      420

aaaggcctga agattcccca gctataccag tctggagtgg ttgtcctggt tcttactgtg      480

ttgtcctcta tggggctggc agccatgtga                                       510


<210>  149
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  149
atgttgggta aaggaggaaa acggaagttt gatgagcatg aagatgggct ggaaggcaaa       60

atcgtgtctc cctgtgacgg tccatccaag gtgtcttaca ccttacagcg ccagactatc      120

ttcaacattt cccttatgaa actctataac cacaggcccc tgacagagcc cagcttgcaa      180

aagaccgttt taattaacaa catgttgagg cggatccagg aggaactcaa acaggaaggc      240

agcctgaggc ccatgttcac cccctcctcc cagcccacca ccgagcccag cgacagctac      300

cgagaggccc cgccggcctt cagccacctg gcgtccccgt cctcccaccc ctgcgacctc      360

ggaagcacta cgcccctgga ggcctgcctc accccggcct cactgctcga ggacgacgat      420

gacacgtttt gcacctccca ggccatgcag cccacggctc ccaccaaact gtcacctcca      480

gccctcttgc cagaaaagga cagtttctcc tctgccttgg acgagatcga ggagctctgt      540

cccacatcta cctccacaga ggcggccacg gctgcgactg acagtgtgaa agggacctcc      600

agcgaggctg gcacccagaa actcgacggt cctcaagaga gccgcgcaga tgactcaaaa      660

ctgatggact ctctgcctgg gaattttgaa ataacgacgt ccacgggttt cctgacagac      720

ttgaccctgg atgacatcct gtttgctgac attgatacgt ccatgtatga ttttgacccc      780

tgcacttcct catcagggac agcctcaaaa atggcccctg tgtctgccga cgacctcctc      840

aaaactctgg ctccttacag cagtcagcct gtcaccccaa gtcagccttt caaaatggac      900

ctcacagagc tggaccacat catggaggtg cttgttgggt cctaa                      945


<210>  150
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  150
atggtgatcc gtgtatatat tgcatcttcc tctggctcta cagcgattaa gaagaaacaa       60

caagatgtgc ttggtttcct agaagccaac aaaataggat ttgaagaaaa agatattgca      120

gccaatgaag agaatcggaa gtggatgaga gaaaatgtac ctgaaaatag tcgaccagcc      180

acaggttacc ccctgccacc tcagattttc aatgaaagcc agtatcgcgg ggactatgat      240

gccttctttg aagccagaga aaataatgca gtgtatgcct tcttaggctt gacagcccca      300

cctggttcaa aggaagcaga agtgcaagca aagcagcaag catga                      345


<210>  151
<211>  1188
<212>  DNA
<213>  Homo sapiens

<400>  151
atggacttca acatgaagaa gctggcgtcg gacgcgggca tcttcttcac ccgggcggtg       60

cagttcacgg aggagaaatt tggccaggct gagaagactg agcttgatgc ccactttgaa      120

aaccttctgg cccgggcaga cagcaccaag aactggacag agaagatctt gaggcagaca      180

gaggtgctgc tgcagcccaa ccccagtgcc cgagtggagg agttcctgta tgagaagctg      240

gacaggaagg tcccctcaag ggtcaccaac ggggagctgc tggctcagta catggcagac      300

gcggccagtg agctggggcc gaccaccccc tatgggaaga cactgatcaa ggtggcagaa      360

gctgaaaagc aactgggagc cgcggagagg gattttatcc acacggcctc catcagcttc      420

ctcacaccct tgcgcaactt cctggagggg gactggaaga ccatctcgaa ggagaggcgg      480

ctcctccaaa accggcgtct ggacttggat gcctgcaaag cgaggctgaa gaaggccaag      540

gctgcagaag ccaaagccac gacggtgcct gactttcagg agactagacc tcgtaattac      600

attctctcgg ccagcgcctc cgcgctctgg aatgatgaag tggacaaggc cgagcaggag      660

ctccgcgtgg cccagacaga gtttgaccgg caagcagaag tgacccgtct cttgctggag      720

ggaatcagta gcactcacgt gaaccacctg cgctgcctcc acgagttcgt caagtctcag      780

acaacctact acgcacagtg ctaccgccac atgctggact tgcagaagca gctgggcaga      840

tttcccggca ccttcgtggg caccacagag cccgcctccc cacccctgag cagcacctca      900

cccaccactg ctgcggccac tatgcctgtg gtgccctctg tggccagcct ggcccctccg      960

ggggaggcct cgctctgcct ggaagaggtg gccccccctg ccagtgggac ccgcaaagct     1020

cgggtgctct atgactacga ggcagccgac agcagtgagc tggccctgct ggctgatgag     1080

ctcatcactg tctacagcct gcctggcatg gaccctgact ggctcattgg cgagagaggc     1140

aacaagaagg gcaaggtccc tgtcacctac ttggaactgc tcagctag                  1188


<210>  152
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  152
atggctggtt ccccaacatg cctcaccctc atctatatcc tttggcagct cacagggtca       60

gcagcctctg gacccgtgaa agagctggtc ggttccgttg gtggggccgt gactttcccc      120

ctgaagtcca aagtaaagca agttgactct attgtctgga ccttcaacac aacccctctt      180

gtcaccatac agccagaagg gggcactatc atagtgaccc aaaatcgtaa tagggagaga      240

gtagacttcc cagatggagg ctactccctg aagctcagca aactgaagaa gaatgactca      300

gggatctact atgtggggat atacagctca tcactccagc agccctccac ccaggagtac      360

gtgctgcatg tctacgagca cctgtcaaag cctaaagtca ccatgggtct gcagagcaat      420

aagaatggca cctgtgtgac caatctgaca tgctgcatgg aacatgggga agaggatgtg      480

atttatacct ggaaggccct ggggcaagca gccaatgagt cccataatgg gtccatcctc      540

cccatctcct ggagatgggg agaaagtgat atgaccttca tctgcgttgc caggaaccct      600

gtcagcagaa acttctcaag ccccatcctt gccaggaagc tctgtgaagg tgctgctgat      660

gacccagatt cctccatggt cctcctgtgt ctcctgttgg tgcccctcct gctcagtctc      720

tttgtactgg ggctatttct ttggtttctg aagagagaga gacaagaaga gtacattgaa      780

gagaagaaga gagtggacat ttgtcgggaa actcctaaca tatgccccca ttctggagag      840

aacacagagt acgacacaat ccctcacact aatagaacaa tcctaaagga agatccagca      900

aatacggttt actccactgt ggaaataccg aaaaagatgg aaaatcccca ctcactgctc      960

acgatgccag acacaccaag gctatttgcc tatgagaatg ttatctag                  1008


<210>  153
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  153
atggtgctgg gtcctgaaca gaagatgtca gatgacagtg tttctggaga tcatggggag       60

tctgccagtc ttggtaacat caaccctgcc tatagtaatc cctctctttc acagtcccct      120

ggggactcag aggagtactt cgccacttac tttaatgaga agatctccat tcctgaggag      180

gagtactctt gttttagctt tcgtaaactc tgggctttca ccggaccagg ttttcttatg      240

agcattgcct acctggatcc aggaaatatt gaatccgatt tgcagtctgg agcagtggct      300

ggatttaagt tgctctggat ccttctgttg gccacccttg tggggctgct gctccagcgg      360

cttgcagcta gactgggagt ggttactggg ctgcatcttg ctgaagtatg tcaccgtcag      420

tatcccaagg tcccacgagt catcctgtgg ctgatggtgg agttggctat catcggctca      480

gacatgcaag aagtcattgg ctcagccatt gctatcaatc ttctgtctgt aggaagaatt      540

cctctgtggg gtggcgttct catcaccatt gcagatactt ttgtatttct cttcttggac      600

aaatatggct tgcggaagct agaagcattt tttggctttc tcatcactat tatggccctc      660

acatttggat atgagtatgt tacagtgaaa cccagccaga gccaggtact caagggcatg      720

ttcgtaccat cctgttcagg ctgtcgcact ccacagattg aacaggctgt gggcatcgtg      780

ggagctgtca tcatgccaca caacatgtac ctgcattctg ccttagtcaa gtctagacag      840

gtaaaccgga acaataagca ggaagttcga gaagccaata agtacttttt cattgaatcc      900

tgcattgcac tctttgtttc cttcatcatc aatgtctttg ttgtctcagt ctttgctgaa      960

gcattttttg ggaaaaccaa cgagcaggtg gttgaagtct gtacaaatac cagcagtcct     1020

catgctggcc tctttcctaa agataactcg acactggctg tggacatcta caaagggggt     1080

gttgtgctgg gatgttactt tgggcctgct gcactctaca tttgggcagt ggggatcctg     1140

gctgcaggac agagctccac catgacagga acctattctg gccagtttgt catggaggga     1200

ttcctgaacc taaagtggtc acgctttgcc cgagtggttc tgactcgctc tattgccatc     1260

atccccactc tgcttgttgc tgtcttccaa gatgtagagc atctaacagg gatgaatgac     1320

tttctgaatg ttctacagag cttacagctt ccctttgctc tcatacccat cctcacattt     1380

acgagcttgc ggccagtaat gagtgacttt gccaatggac taggctggcg gattgcagga     1440

ggaatcttgg tccttatcat ctgttccatc aatatgtact ttgtagtggt ttatgtccgg     1500

gacctagggc atgtggcatt atatgtggtg gctgctgtgg tcagcgtggc ttatctgggc     1560

tttgtgttct acttgggttg gcaatgtttg attgcactgg gcatgtcctt cctggactgt     1620

gggcatacgg taagcatctc taaaggcctg ctgacagaag aagccacccg tggctacgtt     1680

aaataa                                                                1686


<210>  154
<211>  2745
<212>  DNA
<213>  Homo sapiens

<400>  154
atggccagcg agagctcacc tctgctggcc taccggctcc tgggggagga gggggttgcc       60

ctccctgcca atggggccgg gggtcctgga ggggcgtctg cccggaagct gtccaccttc      120

ctgggtgtgg tggtgcccac tgtcctgtcc atgttcagca tagttgtttt tctgaggatt      180

gggttcgtgg tgggtcatgc tgggctactg caggccctgg ccatgctgct ggttgcctac      240

ttcatcctgg cactcaccgt cctctctgtc tgtgccatcg ccaccaatgg agccgtgcag      300

gggggcggag cctacttcat gatcagccgc acactggggc ccgaggtcgg gggcagcatt      360

gggctcatgt tctacctggc taacgtctgt ggctgtgccg tctccctcct ggggctggtg      420

gagtctgtgc ttgatgtctt cggggccgat gccacagggc ccagtgggct ccgggtcctg      480

ccccagggct acggctggaa cctgctgtat ggctccctgc tgctgggcct tgtgggtggg      540

gtctgcaccc tgggagccgg cctctatgcc cgggcctcat tcctcacatt cctgctggtc      600

tctggctccc tggcctctgt gctcatcagt tttgtggctg tggggccgag ggacatccgc      660

ttgactccta ggcctggccc caatggctcc tccctgccgc cccggtttgg ccacttcacc      720

ggcttcaaca gcagtaccct gaaggacaac ttgggcgctg gctatgctga ggactacacc      780

acgggagccg tgatgaattt tgccagcgtc tttgctgtcc tctttaacgg ctgtacaggc      840

atcatggctg gggccaacat gtcaggggag ctgaaggacc ccagccgggc gatccctctg      900

ggcacgatcg tcgccgtcgc ctacaccttc ttcgtctatg tcctgctttt ctttctctcc      960

agcttcactt gtgacaggac cctgctgcag gaagactatg ggttcttccg cgccatcagc     1020

ctgtggcccc cactggtgtt gatcggaatc tatgccacag cgctctcagc gtccatgagc     1080

tcgctcattg gtgcctcccg catcctccat gccctggccc gggatgacct ctttggcgtg     1140

atcttggcac cggccaaggt tgtgtcccga gggggaaacc cctgggcagc tgtactttat     1200

tcttggggcc tggtgcagct ggtgctcctg gctgggaagc tgaacacact ggctgctgtg     1260

gtcactgtct tctacctggt ggcctatgct gccgtggacc tgtcctgcct gagcctggag     1320

tgggcctcgg cccccaactt ccgccccacc ttcagcctgt tctcctggca cacctgcctg     1380

ctgggggtgg cctcctgcct gctcatgatg ttcctcatca gtcctggcgc ggctggtggc     1440

tccctgctcc tcatgggtct gctggctgcc ctgctcaccg cgcgaggagg ccccagtagc     1500

tggggctatg tcagccaggc cttgcttttc caccaggtgc gtaagtatct gcttcggctg     1560

gacgtccgga aggatcacgt gaagttctgg cggccccagc tgctgctcct ggtggggaac     1620

ccccggggcg ccctgcctct gctgcggttg gccaaccagc ttaagaaggg ggggctgtat     1680

gtgctgggcc acgtcaccct gggagacctc gactccctgc cctcggaccc tgtacagccg     1740

cagtatgggg catggctcag cctggtggac cgtgcccagg tgaaggcttt tgtggatcta     1800

accctctcac cctccgtgcg ccagggggct cagcatctgc tgcgaatctc cggcctcggt     1860

ggcatgaagc ccaacacgtt ggtcctaggt ttctacgatg acgctccacc gcaggaccat     1920

ttcctgacgg acccggcttt ctctgagcct gcagacagca ccagggaggg cagttcccca     1980

gctctgagca ccctgttccc tcctccccgg gctcctggga gcccccgggc cctcaatccc     2040

caggactatg tggccacggt ggccgacgcc ctcaagatga acaagaatgt ggtgctggcc     2100

cgggccagcg gggccttgcc ccctgagcgg ctgagccggg ggtctggggg cacctctcag     2160

ctgcaccatg tggacgtgtg gcccctcaac ctgctgcggc cccggggtgg gcccggctat     2220

gtggatgtct gcggcctctt cctgctgcag atggcaacca tcttgggcat ggtgcccgct     2280

tggcatagcg cccggctccg gatcttcctg tgcctggggc ctcgggaggc gcctggggcg     2340

gccgaggggc ggctgcgggc actgctgagc caactgagga tccgggctga ggtgcaggag     2400

gtggtgtggg gcgagggggc cggggctggg gaacccgagg cggaggagga aggggacttt     2460

gtgaacagtg ggcggggaga cgcagaggca gaggccctgg cacgcagcgc caacgccctg     2520

gttcgggccc agcaggggcg cggcacagga ggagggccgg gtgggccgga gggtggggat     2580

gctgagggcc ccatcacagc cctcaccttc ctgtacttgc ctcggccgcc agccgatccc     2640

gcccgatacc cccgctacct ggcgctactg gagactctaa cccgagacct gggccccacg     2700

ctgctggttc atggggtcac tccagtcacc tgcactgatc tgtga                     2745


<210>  155
<211>  1017
<212>  DNA
<213>  Homo sapiens

<400>  155
atggagctgc gcagcgggag cgtgggcagc caggcggtgg cgcggaggat ggatggggac       60

agccgagatg gcggcggcgg caaggacgcc accgggtcgg aggactacga gaacctgccg      120

actagcgcct ccgtgtccac ccacatgaca gcaggagcga tggccgggat cctggagcac      180

tcggtcatgt acccggtgga ctcggtgaag acacgaatgc agagtttgag tccagatccc      240

aaagcccagt acacaagtat ctacggagcc ctcaagaaaa tcatgcggac cgaaggcttc      300

tggaggccct tgcgaggcgt caacgtcatg atcatgggtg cagggccggc ccatgccatg      360

tattttgcct gctatgaaaa catgaaaagg actttaaatg acgttttcca ccaccaagga      420

aacagccacc tagccaacgg gatagctggg agtatggcca ccctgctcca cgatgcggta      480

atgaatccag cagaagtggt gaagcagcgc ttgcagatgt acaactcgca gcaccggtca      540

gcaatcagct gcatccggac ggtgtggagg accgaggggt tgggggcctt ctaccggagc      600

tacaccacgc agctgaccat gaacatcccc ttccagtcca tccacttcat cacctatgag      660

ttcctgcagg agcaggtcaa cccccaccgg acctacaacc cgcagtccca catcatctca      720

ggcgggctgg ccggggccct cgccgcggcc gccacgaccc ccctggacgt ctgtaagacc      780

cttctgaaca ctcaggagaa cgtggccctc tcgctggcca acatcagcgg ccggctgtcg      840

ggtatggcca atgccttccg gacggtgtac cagctcaacg gcctggccgg ctacttcaaa      900

ggcatccagg cgcgtgtcat ctaccagatg ccctccaccg ccatttcttg gtctgtctat      960

gagttcttca agtactttct caccaagcgc cagctggaaa atcgagctcc atactaa        1017


<210>  156
<211>  1491
<212>  DNA
<213>  Homo sapiens

<400>  156
atggggacac agaaggtcac cccagctctg atatttgcca tcacagttgc tacaatcggc       60

tctttccaat ttggctacaa cactggggtc atcaatgctc ctgagaagat cataaaggaa      120

tttatcaata aaactttgac ggacaaggga aatgccccac cctctgaggt gctgctcacg      180

tctctctggt ccttgtctgt ggccatattt tccgtcgggg gtatgatcgg ctccttttcc      240

gtcggactct tcgtcaaccg ctttggcagg cgcaattcaa tgctgattgt caacctgttg      300

gctgtcactg gtggctgctt tatgggactg tgtaaagtag ctaagtcggt tgaaatgctg      360

atcctgggtc gcttggttat tggcctcttc tgcggactct gcacaggttt tgtgcccatg      420

tacattggag agatctcgcc tactgccctg cggggtgcct ttggcactct caaccagctg      480

ggcatcgttg ttggaattct ggtggcccag atctttggtc tggaattcat ccttgggtct      540

gaagagctat ggccgctgct actgggtttt accatccttc ctgctatcct acaaagtgca      600

gcccttccat tttgccctga aagtcccaga tttttgctca ttaacagaaa agaagaggag      660

aatgctaagc agatcctcca gcggttgtgg ggcacccagg atgtatccca agacatccag      720

gagatgaaag atgagagtgc aaggatgtca caagaaaagc aagtcaccgt gctagagctc      780

tttagagtgt ccagctaccg acagcccatc atcatttcca ttgtgctcca gctctctcag      840

cagctctctg ggatcaatgc tgtgttctat tactcaacag gaatcttcaa ggatgcaggt      900

gttcaagagc ccatctatgc caccatcggc gcgggtgtgg ttaatactat cttcactgta      960

gtttctctat ttctggtgga aagggcagga agaaggactc tgcatatgat aggccttgga     1020

gggatggctt tttgttccac gctcatgact gtttctttgt tattaaagga taactataat     1080

gggatgagct ttgtctgtat tggggctatc ttggtctttg tagccttctt tgaaattgga     1140

ccaggcccca ttccctggtt tattgtggcc gaactcttca gccagggccc ccgcccagct     1200

gcgatggcag tggccggctg ctccaactgg acctccaact tcctagtcgg attgctcttc     1260

ccctccgctg ctcactattt aggagcctac gtttttatta tcttcaccgg cttcctcatt     1320

accttcttgg cttttacctt cttcaaagtc cctgagaccc gtggcaggac ttttgaggat     1380

atcacacggg cctttgaagg gcaggcacac ggtgcagata gatctggaaa ggacggcgtc     1440

atggagatga acagcatcga gcctgctaag gagaccacca ccaatgtcta a              1491


<210>  157
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  157
atggccccgg gtcgcgcggt ggccgggctc ctgttgctgg cggccgccgg cctcggagga       60

gtggcggagg ggccagggct agccttcagc gaggatgtgc tgagcgtgtt cggcgcgaat      120

ctgagcctgt cggcggcgca gctccagcac ttgctggagc agatgggagc cgcctcccgc      180

gtgggcgtcc cggagcctgg ccagctgcac ttcaaccagt gtttaactgc tgaagagatc      240

ttttcccttc atggcttttc aaatgctacc caaataacca gctccaaatt ctctgtcatc      300

tgtccagcag tcttacagca attgaacttt cacccatgtg aggatcggcc caagcacaaa      360

acaagaccaa gtcattcaga agtttgggga tatggattcc tgtcagtgac gattattaat      420

ctggcatctc tcctcggatt gattttgact ccactgataa agaaatctta tttcccaaag      480

attttgacct tttttgtggg gctggctatt gggactcttt tttcaaatgc aattttccaa      540

cttattccag aggcatttgg atttgatccc aaagtcgaca gttatgttga gaaggcagtt      600

gctgtgtttg gtggatttta cctacttttc ttttttgaaa gaatgctaaa gatgttatta      660

aagacatatg gtcagaatgg tcatacccac tttggaaatg ataactttgg tcctcaagaa      720

aaaactcatc aacctaaagc attacctgcc atcaatggtg tgacatgcta tgcaaatcct      780

gctgtcacag aagctaatgg acatatccat tttgataatg tcagtgtggt atctctacag      840

gatggaaaaa aagagccaag ttcatgtacc tgtttgaagg ggcccaaact gtcagaaata      900

gggacgattg cctggatgat aacgctctgc gatgccctcc acaatttcat cgatggcctg      960

gcgattgggg cttcctgcac cttgtctctc cttcagggac tcagtacttc catagcaatc     1020

ctatgtgagg agtttcccca cgagttagga gactttgtga tcctactcaa tgcagggatg     1080

agcactcgac aagccttgct attcaacttc ctttctgcat gttcctgcta tgttgggcta     1140

gcttttggca ttttggtggg caacaatttc gctccaaata ttatatttgc acttgctgga     1200

ggcatgttcc tctatatttc tctggcagat atgtttccag agatgaatga tatgctgaga     1260

gaaaaggtaa ctggaagaaa aaccgatttc accttcttca tgattcagaa tgctggaatg     1320

ttaactggat tcacagccat tctactcatt accttgtatg caggagaaat cgaattggag     1380

taa                                                                   1383


<210>  158
<211>  1077
<212>  DNA
<213>  Homo sapiens

<400>  158
atgagcgcgg acgcagcggc cggggcgccc ctgccccggc tctgctgcct ggagaagggt       60

ccgaacggct acggcttcca cctgcacggg gagaagggca agttgggcca gtacatccgg      120

ctggtggagc ccggctcgcc ggccgagaag gcggggctgc tggcggggga ccggctggtg      180

gaggtgaacg gcgaaaacgt ggagaaggag acccaccagc aggtggtgag ccgcatccgc      240

gccgcactca acgccgtgcg cctgctggtg gtcgaccccg agacggacga gcagctgcag      300

aagctcggcg tccaggtccg agaggagctg ctgcgcgccc aggaagcgcc ggggcaggcc      360

gagccgccgg ccgccgccga ggtgcagggg gctggcaacg aaaatgagcc tcgcgaggcc      420

gacaagagcc acccggagca gcgcgagctt cggcctcggc tctgtaccat gaagaagggc      480

cccagtggct atggcttcaa cctgcacagc gacaagtcca agccaggcca gttcatccgg      540

tcagtggacc cagactcccc ggctgaggct tcagggctcc gggcccagga tcgcattgtg      600

gaggtgaacg gggtctgcat ggaggggaag cagcatgggg acgtggtgtc cgccatcagg      660

gctggcgggg acgagaccaa gctgctggtg gtggacaggg aaactgacga gttcttcaag      720

aaatgcagag tgatcccatc tcaggagcac ctgaatggtc ccctgcctgt gcccttcacc      780

aatggggaga tacagaagga gaacagtcgt gaagccctgg cagaggcagc cttggagagc      840

cccaggccag ccctggtgag atccgcctcc agtgacacca gcgaggagct gaattcccaa      900

gacagccccc caaaacagga ctccacagcg ccctcgtcta cctcctcctc cgaccccatc      960

ctagacttca acatctccct ggccatggcc aaagagaggg cccaccagaa acgcagcagc     1020

aaacgggccc cgcagatgga ctggagcaag aaaaacgaac tcttcagcaa cctctga        1077


<210>  159
<211>  1107
<212>  DNA
<213>  Homo sapiens

<400>  159
atggggactc ctcccggcct gcagaccgac tgcgaggcgc tgctcagccg cttccaggag       60

acggacagtg tacgcttcga ggacttcacg gagctctgga gaaacatgaa gttcgggact      120

atcttctgtg gcagaatgag aaatttagaa aagaacatgt ttacaaaaga agctttagct      180

ttggcttggc gatatttttt acctccatac accttccaga tcagagttgg tgctttgtat      240

ctgctatatg gattatataa tacccaactg tgtcaaccaa aacaaaagat cagagttgcc      300

ctgaaggatt gggatgaagt tttaaaattt cagcaagatt tagtaaatgc acagcatttt      360

gatgcagctt atatttttag gaagctacga ctagacagag catttcactt tacagcaatg      420

cccaaattgc tgtcatatag gatgaagaaa aaaattcacc gagctgaagt tacagaagaa      480

tttaaggacc caagtgatcg tgtgatgaaa cttatcactt ctgatgtatt agaggaaatg      540

ctgaatgttc atgatcatta tcagaacatg aaacatgtaa tttcagttga taagtccaag      600

ccagataaag ccctcagctt gataaaggat gatttttttg acaatattaa gaacatagtt      660

ttggagcatc agcagtggca caaagacaga aagaatccat ccttaaagtc aaaaactaat      720

gatggagaag aaaaaatgga aggaaattca caagaaacgg agagatgtga aagggcagaa      780

tcattagcga aaataaaatc aaaggccttt tcagttgtca tacaggcatc caaatcaaga      840

aggcatcgtc aagtcaaact cgactcttct gactctgatt ctgcatctgg tcaagggcaa      900

gtcaaagcaa ctaggaaaaa agagaagaaa gaaagattga aaccagcagg aaggaagatg      960

tctctcagaa acaaaggcaa tgtgcagaat atacacaagg aagataaacc tttaagtctg     1020

agtatgcctg taattacaga agaagaagag aatgaaagtt tgagtggaac agagttcact     1080

gcatccaaga agaggagaaa acactga                                         1107


<210>  160
<211>  2496
<212>  DNA
<213>  Homo sapiens

<400>  160
atggagcggc cctggggagc tgcggacggc ctctcgcgct ggccccatgg cctcggcctc       60

ctcctcctcc tgcagctgct gccgccgtcg accctcagcc aggaccggct ggacgcgccg      120

ccgccgcccg ctgcgccgct gccgcgctgg tctggcccca tcggggtgag ctgggggctg      180

cgggcggccg cagccggggg cgcgtttccc cgcggcggcc gttggcgtcg cagcgcgccg      240

ggcgaggacg aggagtgcgg ccgggtccgg gacttcgtcg ccaagctggc caacaacacg      300

caccagcatg tgtttgatga tctcagaggc tcagtatcct tgtcctgggt tggagatagc      360

actggggtca ttctagtctt gactaccttc catgtaccac tggtaattat gacttttgga      420

cagtccaagc tatatcgaag tgaggattat gggaagaact ttaaggatat tacagatctc      480

atcaataaca cctttattcg gactgaattt ggcatggcta ttggtcctga gaactctgga      540

aaggtggtgt taacagcaga ggtgtctgga ggaagtcgtg gaggaagaat ctttagatca      600

tcagattttg cgaagaattt tgtgcaaaca gatctccctt ttcatcctct cactcagatg      660

atgtatagcc ctcagaattc tgattatctt ttagctctca gcactgaaaa tggcctgtgg      720

gtgtccaaga attttggggg aaaatgggaa gaaatccaca aagcagtatg tttggccaaa      780

tggggatcag acaacaccat cttctttaca acctatgcaa atggctcctg caaagctgac      840

cttggggctc tggaattatg gagaacttca gacttgggaa aaagcttcaa aactattggt      900

gtgaaaatct actcatttgg tcttggggga cgtttccttt ttgcctctgt gatggctgat      960

aaggatacaa caagaaggat ccacgtttca acagatcaag gggacacatg gagcatggcc     1020

cagctcccct ccgtgggaca ggaacagttc tattctattc tggcagcaaa tgatgacatg     1080

gtattcatgc atgtagatga acctggagac actgggtttg gcacaatctt tacctcagat     1140

gatcgaggca ttgtctattc caagtctttg gaccgacatc tctacactac cacaggcgga     1200

gagacggact ttaccaacgt gacctccctc cgcggcgtct acataacaag cgtgctctcc     1260

gaagataatt ctatccagac catgatcact tttgaccaag gaggaaggtg gacgcacctg     1320

aggaagcctg aaaacagtga atgtgatgct acagcaaaaa acaagaatga gtgcagcctt     1380

catattcatg cttcctacag catctcccag aaactgaatg ttccaatggc cccactctca     1440

gagccgaatg ccgtaggcat tgtcattgct catggtagcg tgggggatgc catctcagtg     1500

atggttccag atgtgtacat ctcagatgat gggggttact cctggacaaa gatgctggaa     1560

ggaccccact attacaccat cctggattct ggaggcatca ttgtggccat tgagcacagc     1620

agccgtccta tcaatgtgat taagttctcc acagacgaag gtcaatgctg gcaaacctac     1680

acgttcacca gggaccccat ctatttcact ggcctagctt cagaacctgg agctaggtcc     1740

atgaatatca gcatttgggg cttcacagaa tctttcctga ccagccagtg ggtctcctac     1800

accattgatt ttaaagatat ccttgaaagg aactgtgaag agaaggacta taccatatgg     1860

ctggcacact ccacagaccc tgaagattat gaagatggct gcattttggg ctacaaagaa     1920

cagtttctgc ggctacgcaa gtcatccgtg tgtcagaatg gtcgagacta tgttgtgacc     1980

aagcagccct ccatctgcct ctgttccctg gaggactttc tctgtgattt tggctactac     2040

cgtccagaaa atgactccaa gtgtgtggaa cagccagaac tgaagggcca cgacctggag     2100

ttttgtctgt acggaagaga agaacaccta acaacaaatg ggtaccggaa aattccaggg     2160

gacaaatgcc agggtggggt aaatccagtt cgagaagtaa aagacttgaa aaagaaatgc     2220

acaagcaact ttttgagtcc ggaaaaacag aattccaagt caaattctgt tccaattatc     2280

ctggccatcg tgggattgat gctggtcaca gtcgtagcag gagtgctcat tgtgaagaaa     2340

tatgtctgtg ggggaaggtt cctggtgcat cgatactctg tgctgcagca gcatgcagag     2400

gccaatggtg tggatggtgt ggatgctttg gacacagcct cccacactaa taaaagtggt     2460

tatcatgatg actcagatga ggacctcttg gaatag                               2496


<210>  161
<211>  1086
<212>  DNA
<213>  Homo sapiens

<400>  161
atgtacggca aaggcaagag taacagcagc gccgtcccgt ccgacagcca ggcccgggag       60

aagttagcac tctacgtata tgaatatctg ctccatgtag gagctcagaa atcagctcaa      120

acatttttat cagagataag atgggaaaaa aacatcacat tgggggaacc accaggattc      180

ttacattctt ggtggtgtgt attttgggat ctctactgtg cagctccaga gagacgtgaa      240

acatgtgaac actcaagtga agcaaaagcc ttccatgatt acagtgctgc agcagctccc      300

agtccagtgc taggaaacat tcccccagga gatggcatgc cagtaggtcc tgtaccacca      360

gggttctttc agccttttat gtcacctcgg taccctggag gtccaaggcc cccattgagg      420

atacctaatc aggcacttgg aggtgtccca ggaagtcagc cattactccc cagtggaatg      480

gatccaactc gacaacaagg acatccaaat atgggtgggc caatgcagag aatgactcct      540

ccaagaggaa tggtgccctt aggaccacag aactatggag gtgcaatgag acccccactg      600

aatgctttag gtggccctgg aatgcctgga atgaacatgg gtccaggtgg tggtagacct      660

tggccaaacc caacaaatgc caattcaata ccatactcct cagcatctcc tgggaattat      720

gtaggtcctc caggaggtgg agggccacca ggaacaccca tcatgcctag tccagcagat      780

tcaaccaact ctggtgataa catgtatact ttaatgaatg cagtacctcc tggacctaac      840

agacctaatt ttccaatggg tcctgggtca gatggtccca tgggtggatt aggaggaatg      900

gagtcacatc acatgaatgg ctctttaggc tcaggagata tggacagtat ttccaagaat      960

tctcccaata atatgagcct gagtaatcaa ccgggcactc caagggatga tggcgaaatg     1020

gggggaaatt tcttaaatcc ttttcagagt gagagttact cccctagcat gacaatgagc     1080

gtgtga                                                                1086


<210>  162
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  162
atgcggacga aggcggcggg ctgcgcggag cggcgtcccc tgcagccgcg gaccgaggca       60

gcggcggcac ctgccggccg agcaatgcca agtgagtaca cctatgtgaa actgagaagt      120

gattgctcga ggccttccct gcaatggtac acccgagctc aaagcaagat gagaaggccc      180

agcttgttat taaaagacat cctcaaatgt acattgcttg tgtttggagt gtggatcctt      240

tatatcctca agttaaatta tactactgaa gaatgtgaca tgaaaaaaat gcattatgtg      300

gaccctgacc atgtaaagag agctcagaaa tatgctcagc aagtcttgca gaaggaatgt      360

cgtcccaagt ttgccaagac atcaatggcg ctgttatttg agcacaggta tagcgtggac      420

ttactccctt ttgtgcagaa ggcccccaaa gacagtgaag ctgagtccaa gtacgatcct      480

ccttttgggt tccggaagtt ctccagtaaa gtccagaccc tcttggaact cttgccagag      540

cacgacctcc ctgaacactt gaaagccaag acctgtcggc gctgtgtggt tattggaagc      600

ggaggaatac tgcacggatt agaactgggc cacaccctga accagttcga tgttgtgata      660

aggttaaaca gtgcaccagt tgagggatat tcagaacatg ttggaaataa aactactata      720

aggatgactt atccagaggg cgcaccactg tctgaccttg aatattattc caatgactta      780

tttgttgctg ttttatttaa gagtgttgat ttcaactggc ttcaagcaat ggtaaaaaag      840

gaaaccctgc cattctgggt acgactcttc ttttggaagc aggtggcaga aaaaatccca      900

ctgcagccaa aacatttcag gattttgaat ccagttatca tcaaagagac tgcctttgac      960

atccttcagt actcagagcc tcagtcaagg ttctggggcc gagataagaa cgtccccaca     1020

atcggtgtca ttgccgttgt cttagccaca catctgtgcg atgaagtcag tttggcgggt     1080

tttggatatg acctcaatca acccagaaca cctttgcact acttcgacag tcaatgcatg     1140

gctgctatga actttcagac catgcataat gtgacaacgg aaaccaagtt cctcttaaag     1200

ctggtcaaag agggagtggt gaaagatctc agtggaggca ttgatcgtga attttga        1257


<210>  163
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  163
atgagagggt atcttgtggc catattcctg agtgctgtct tcctctatta tgtactgcat       60

tgcatattat ggggaacgaa tgtctattgg gtggcacctg tggaaatgaa acggagaaat      120

aagatccagc cttgtttatc aaagccagct tttgcctctc tgctgaggtt tcatcagttt      180

cacccttttc tgtgtgcggc tgattttaga aagattgctt ccttgtatgg tagcgataag      240

tttgatttgc cctatgggat gagaacatca gcggaatatt ttcgacttgc tctttcaaaa      300

ctgcagagtt gtgatctctt tgatgagttt gacaacatac cctgtaaaaa gtgtgtggtg      360

gttggtaatg gaggagtttt gaagaataag acattaggag aaaaaatcga ctcctatgat      420

gtaataataa gaatgaataa tggtcctgtt ttaggacatg aagaagaagt tgggagaagg      480

acaaccttcc gactttttta tccagaatct gttttttcag atcctattca caatgaccct      540

aatacgacag tgattctcac tgcttttaag ccacatgatt taaggtggct gttggaattg      600

ttgatgggtg acaaaataaa cactaatggt ttttggaaga aaccagcctt aaacctgatt      660

tataaacctt atcaaatccg aatattagat cctttcatta tcagaacagc agcttatgaa      720

ctgcttcatt ttccaaaagt gtttcccaaa aatcagaaac ctaaacaccc aacaacagga      780

attattgcca tcacattggc gttttacata tgtcacgaag ttcacctagc tggttttaaa      840

tacaactttt ctgacctcaa gagtcctttg cactactatg ggaatgccac catgtctttg      900

atgaataaga acgcgtatca caatgtgact gcagagcagc tctttttgaa ggacattata      960

gaaaaaaacc tcgtaatcaa cttgactcaa gattga                                996


<210>  164
<211>  1398
<212>  DNA
<213>  Homo sapiens

<400>  164
atggcaatga caggctcaac accttgctca tccatgagta accacacaaa ggaaagggtg       60

acaatgacca aagtgacact ggagaatttt tatagcaacc ttatcgctca acatgaagaa      120

cgagaaatga gacaaaagaa gttagaaaag gtgatggaag aagaaggcct aaaagatgag      180

gagaaacgac tccggagatc agcacatgct cggaaggaaa cagagtttct tcgtttgaag      240

agaacaagac ttggattgga agattttgag tccttaaaag taataggcag aggagcattt      300

ggtgaggtac ggcttgttca gaagaaagat acgggacatg tgtatgcaat gaaaatactc      360

cgtaaagcag atatgcttga aaaagagcag gttggccaca ttcgtgcgga gcgtgacatt      420

ctagtggagg cagacagttt gtgggttgtg aaaatgttct atagttttca ggataagcta      480

aacctctacc taatcatgga gttcctgcct ggaggggaca tgatgacctt gttgatgaaa      540

aaagacactc tgacagaaga ggagactcag ttttatatag cagaaacagt attagccata      600

gactctattc accaacttgg attcatccac agagacatca aaccagacaa ccttcttttg      660

gacagcaagg gccatgtgaa actttctgac tttggtcttt gcacaggact gaaaaaagca      720

cataggacag aattttatag gaatctgaac cacagcctcc ccagtgattt cactttccag      780

aacatgaatt ccaaaaggaa agcagaaacc tggaaaagaa atagacgtca gctagccttc      840

tccacagtag gcactcctga ctacattgct cctgaggtgt tcatgcagac cgggtacaac      900

aagctctgtg attggtggtc gcttggggtg atcatgtatg agatgctcat cggctaccca      960

cctttctgtt ctgagacccc tcaagagaca tataagaagg tgatgaactg gaaagaaact     1020

ttgacttttc ctccagaagt tcccatctct gagaaagcca aggatctaat tttgaggttc     1080

tgctgtgaat gggaacatag aattggagct cctggagttg aggaaataaa aagtaactct     1140

ttttttgaag gcgttgactg ggaacatatc agagagagac ctgctgcaat atctattgaa     1200

atcaaaagca ttgatgatac ctcaaacttc gatgagtttc cagaatctga tattcttaag     1260

ccaacagtgg ccacaagtaa tcatcctgag actgactaca agaacaaaga ctgggtcttc     1320

atcaattaca cgtacaagcg ctttgagggc ctgactgcaa ggggggcaat accttcctac     1380

atgaaagcag caaaatag                                                   1398


<210>  165
<211>  20658
<212>  DNA
<213>  Homo sapiens

<400>  165
atggcatcta gtcctgagct tcccaccgaa gatgaacagg gttcctgggg catcgacgat       60

ctccatattt cattgcaagc tgaacaggaa gacacccaga agaaagcctt cacgtgctgg      120

ataaactcac agttggccag gcacacttct ccctcagtta tatccgacct attcacagac      180

attaaaaagg ggcatgtcct cctggatctg ctagaagtac tttctgggca acagttgcct      240

cgggataaag gatctaatac cttccagtgt agaatcaata tagaacatgc cttgacattc      300

ctaagaaacc gatcaattaa gctaataaat attcatgtta ctgatatcat tgatggaaac      360

ccatccatta tccttggcct aatttggaca attatcctgc actttcatat tgagaagctt      420

gcccagactc tttcttgcaa ttacaatcag ccttccctgg atgatgtgag tgtggttgac      480

tcatctcctg cctcaagtcc tccagctaag aaatgctcta aagtgcaagc aagatggcaa      540

atgtctgcaa gaaaggccct tcttttgtgg gctcaggaac aatgcgccac ctatgagtct      600

gtcaatgtga ccgattttaa gtcaagttgg agaaatggga tggctttttt ggccatcatt      660

catgccttgc gaccagacct aattgacatg aagagtgtga agcatagatc caacaaagac      720

aatctgagag aggccttcag aattgcagaa caagaattaa aaatccccag attgctggaa      780

ccagaagatg tggatgttgt tgatcctgat gaaaagtcca tcatgaccta tgtggcacag      840

tttctgcagt attccaaaga tgcccctggg actggagagg aggctcaggg aaaggtgaaa      900

gatgctatgg gctggttaac tctgcaaaag gaaaaactac agaagttgct aaaggattca      960

gagaatgata cctactttaa aaagtataat agcctgctgt cctttatgga gtcattcaat     1020

gaagaaaaaa agtccttttt ggatgtcctg tcaataaaac gggatctgga tgagctggac     1080

aaggatcatt tacagttgag agaagcctgg gatggcctcg atcaccagat taatgcatgg     1140

aaaataaagc taaattatgc cttgccccca cccctccatc aaactgaagc ttggctccag     1200

gaggtagaag agcttatgga tgaagatttg tcagcctccc aggatcactc tcaagccgtg     1260

actctgatac aagagaaaat gactttattc aagagcctga tggatagatt tgagcatcat     1320

tcgaacattc tccttacctt tgaaaataag gatgaaaatc acttgccatt ggtaccacct     1380

aacaaattgg aggaaatgaa aagacgaatc aacaacattt tggagaaaaa atttattcta     1440

cttctagaat ttcattacta caagtgctta gttcttggtt tggtagatga agtgaaatca     1500

aaattggata tttggaacat taaatatggg agcagagaat ctgtggaatt attgctggaa     1560

gactggcata aatttattga agaaaaagaa ttcctagctc gacttgatac ttcttttcaa     1620

aaatgtggag aaatttataa gaatttggct ggagaatgtc agaatattaa taaacagtat     1680

atgatggtga aatctgatgt ttgtatgtat agaaaaaata tatataatgt gaagtccact     1740

ctacaaaaag tgctggcatg ttgggctact tatgtggaaa accttcgctt actaagggct     1800

tgctttgagg agacaaagaa ggaagaaatt aaagaggtac cctttgagac actagcccag     1860

tggaatctag aacacgctac tttaaatgaa gcaggaaatt tcttagtcga agtcagcaat     1920

gatgtggttg gatcatctat ttctaaagaa ctgagaaggc tgaataaaag atggagaaag     1980

ttggtttcaa aaactcaact tgaaatgaac ctgccactga tgataaaaaa acaggatcag     2040

cccacttttg acaattctgg aaatattcta tctaaagaag agaaagcaac tgttgagttt     2100

tcaacagata tgtcagtaga acttcctgaa aattataatc aaaatataaa ggctggagag     2160

aaacatgaaa aagaaaatga agaattcaca gggcaactaa aagtggctaa agatgttgaa     2220

aaactcattg gacaagtgga aatctgggag gcagaagcca aatctgtttt ggatcaagat     2280

gatgtggaca cctcaatgga agaatctttg aagcatctta ttgccaaagg ctctatgttt     2340

gatgagctta tggcaagaag tgaagatatg ttacaaatgg atatacaaaa tatttcaagc     2400

caggagtcct ttcaacatgt tctcacaact gggcttcagg caaagattca agaagctaaa     2460

gagaaagtcc agatcaatgt ggtaaaactc attgcagcgt tgaagaactt aactgacgtt     2520

tcaccagatt tggacatcag gctgaagatg gaagaatccc agaaggaact tgaatcatat     2580

atgatgaggg ctcagcagtt actggggcaa agagagagcc ccggtgaact catttcaaaa     2640

cacaaggaag cactaataat ttctaataca aaaagtctgg ccaagtattt gaaagctgtt     2700

gaagaactaa aaaataatgt aactgaggac ataaagatgt ctttagaaga aaagagtaga     2760

gatgtctgtg ccaaatggga gtctcttcat catgaactgt ctttatatgt tcaacaacta     2820

aaaatagata ttgaaaaagg aaagcttagt gacaatattt taaaacttga aaagcaaata     2880

aataaagaaa agaaacttat ccgtagagga aggaccaagg gtctcatcaa agaacatgag     2940

gcctgctttt ctgaggaagg ctgcctgtac cagcttaatc accacatgga agtcctgagg     3000

gagctgtgtg aagagctgcc ttcacagaag agtcaacaag aagtgaagag actactcaaa     3060

gattatgaac aaaagataga aagacttctg aaatgtgctt ccgagattca tatgacactg     3120

cagcccacag cgggaggcac gtcgaaaaac gaggggacca tcaccacatc tgagaataga     3180

ggaggggatc cccacagtga ggcaccattt gcaaaatcag ataatcagcc atcaactgaa     3240

aaggcaatgg aacccactat gaagtttagc ctggcatcag tgttaaggcc tctgcaagaa     3300

gaaagcatta tggaaaagga ttacagtgca tctataaata gtttactaga gaggtatgat     3360

acatacagag atattcttga acaccacctg caaaacaaca aattcaggat tacttctgat     3420

ttctctagtg aagaggacag gagtagttct tgtctgcagg ctaaactgac agatctacag     3480

gtcataaaaa atgaaactga tgctcgctgg aaagagtttg aaattatttc attgaagtta     3540

gaaaatcatg tgaatgacat aaaaaagcct tttgtaatta aggaaagaga cacactaaag     3600

gaaagagaaa gagagcttca gatgactctt aataccagaa tggaatcttt agagacagca     3660

ctgcggcttg tgttacctgt agagaaggca tcacttcttc tctgtggctc ggacctgcct     3720

ctccataaaa tggccatcca gggatttcat ctcattgatg ctgatcgcat ctatcaacac     3780

ctaaggaata tccaagattc catagcaaaa cagattgaaa tatgtaaccg cttagaagag     3840

ccaggcaact ttgtattaaa ggagttacac ccatttgatc tacacgcaat gcagaatatt     3900

atactgaaat acaaaacaca atttgaagga atgaaccaca gggtgcagag gagtgaagat     3960

actctcaaag ctctggaaga ctttttggcg tctctcagaa cagctaaact ctctgctgag     4020

cccgttacag acctttcagc ctcagataca caggtggcac aagaaaatac gttgacagta     4080

aaaaataaag agggagaaat tcatctgatg aaagacaagg ccaaacattt ggataaatgt     4140

ttgaagatgc tcgatatgag ctttaaagat gctgaacggg gtgatgacac ctcctgtgaa     4200

aacctgcttg atgctttttc aataaagtta tctgagacac atggctatgg ggtacaggag     4260

gaattcactg aggaaaacaa attactagag gcttgtattt tcaaaaataa tgaactcctt     4320

aaaaatattc aagatgtgca gagtcaaatc agtaaaattg gtcttaagga tcctactgtt     4380

ccagctgtga aacatcggaa aaaatcatta atcagactgg ataaggttct agatgaatat     4440

gaagaagaga agagacattt acaagaaatg gctaattctc ttccacactt caaagatggc     4500

agagaaaaaa ccgtgaatca acagtgccaa aatacagtag tcttgtggga gaataccaaa     4560

gccttggtca ccgaatgtct tgaacaatgt gggagagttt tggagctctt aaaacaatat     4620

cagaatttta aaagcatctt gacaactttg attcaaaaag aagagagtgt catctccctg     4680

caggcttcgt acatgggaaa ggagaacctg aagaaaagga tagcagagat tgaaattgtc     4740

aaagaagaat ttaatgagca tttagaagtt gtagacaaga taaaccaggt ctgcaaaaat     4800

ctacaatttt atctaaataa aatgaaaact tttgaagagc ccccttttga aaaagaggct     4860

aatattattg tggatagatg gcttgatata aatgagaaga cagaagatta ctatgaaaat     4920

cttggtcgag ctctagcttt gtgggacaaa ctttttaact taaaaaatgt cattgatgag     4980

tggacagaaa aggcccttca aaaaatggaa ttacatcaat tgactgaaga ggacagagaa     5040

aggctgaagg aagaattaca agtccatgaa caaaaaactt cagaattttc tagaagagtg     5100

gctgaaatac agtttttgct ccaaagcagt gaaatacctc ttgaattgca ggtcatggag     5160

tcctctattt tgaacaagat ggaacatgta cagaagtgct taacaggaga atccaactgc     5220

catgcactca gtggcagcac tgctgagcta agggaggatc tcgaccaagc caagacccag     5280

atcgggatga ctgaatccct cttaaaagcc ctgtctcctt ctgacagctt ggagatcttc     5340

actaaactag aggagataca acagcagatt ctacagcaaa aacacagtat gatattactt     5400

gagaatcaaa taggttgtct gactcctgaa ctctctgaat tgaaaaagca atatgaaagt     5460

gtcagtgatt tatttaatac caaaaaaagt gttttgcaag atcacttttc taagttattg     5520

aatgatcaat gcaagaactt taatgactgg ttcagcaaca ttaaagtgaa ccttaaggag     5580

tgttttgaat catcagaaac aaaaaagagt gtggaacaaa agctacaaaa actttctgat     5640

ttcttgactc ttgaaggaag aaacagtaaa ataaagcagg tggacagcgt actgaagcat     5700

gtgaagaagc atctgcccaa agcacatgtg aaggagctta tcagttggct cgtgggtcag     5760

gaattcgaat tagaaaaaat ggagtccata tgccaggctc gagcaaagga gcttgaagac     5820

tccttgcagc agctactgag actccaggat gaccatagaa acctgaggaa gtggttgact     5880

aatcaagaag agaaatggaa aggaatggaa gaaccagggg agaaaactga gctgttctgc     5940

caagctttag ctagaaagag ggaacagttt gaatctgtgg cccaattgaa caactctttg     6000

aaggaatatg ggtttactga agaagaagaa ataataatgg aagcaacatg tttgatggat     6060

agataccaga cattactgag acaactaagt gaaatcgagg aagaggataa gttactaccc     6120

acagaggacc agagctttaa tgatcttgca catgatgtaa ttcattggat aaaagagatt     6180

aaagagtccc ttatggtttt gaattcatcc gaaggcaaaa tgccacttga ggaaagaatc     6240

caaaaaatca aggaaatcat tttgctgaag cctgaagggg atgccagaat agagaccatc     6300

atgaagcagg ctgagagcag cgaggccccg ctggttcaga agaccctcac tgacatcagc     6360

aaccagtggg acaacacact ccatttagct agcacctacc taagccatca agaaaagctt     6420

ctactagaag gagagaaata tttacaaagt aaggaggatc tgagattaat gctcatagaa     6480

ctaaagaaga aacaggaagc aggctttgct ctacaacatg gtctgcagga gaagaaagct     6540

cagttaaaga tttataagaa attcctcaag aaagcccaag atttgacatc cttgctaaag     6600

gagttaaaat ctcagggaaa ctacctcttg gagtgcacta aaaatcccag cttcagtgaa     6660

gagccttggc tggaaataaa gcatctacac gaaagtcttc ttcaacaact gcaggattct     6720

gtgcaaaact tggacggtca cgttcgagaa catgattcat accaggtttg cgtcacagac     6780

ctgaatacta cattggacaa tttctccaag gaatttgtca gtttttctga taagcctgtg     6840

gatcaaatag cggttgagga aaaattgcag aaactgcagg aactagagaa tagactcagt     6900

ttacaagatg gcacattaaa gaagatttta gctttagcaa aatccgtcaa gcaaaataca     6960

tcttcagtgg ggcagaagat tattaaagat gatataaaat cacttcagtg taaacaaaaa     7020

gatttggaaa acaggcttgc atctgctaag caggagatgg aatgttgtct caacagcatt     7080

ctcaaatcaa aacgctcaac agaaaagaaa ggaaagttta ctctgccagg cagagagaag     7140

caggccactt ctgatgtgca ggagtctact caggaatcag ctgcagtgga aaagttggag     7200

gaagactggg aaataaacaa ggattcagct gtggaaatgg ctatgtcaaa acaactttct     7260

cttaatgctc aagaaagcat gaaaaacact gaagatgagc ggaaagtcaa tgagctgcaa     7320

aatcaacctt tagaattaga tactatgtta agaaatgaac aattagaaga gatagagaaa     7380

ttatataccc agttggaagc aaagaaagca gccattaagc cactggaaca aacagaatgt     7440

cttaacaaaa cagaaactgg ggccttggtt ctccacaata taggatattc ggcacagcat     7500

ttggacaatt tgcttcaggc acttattact ttgaagaaaa acaaagaaag ccaatattgt     7560

gtcctcagag attttcagga ataccttgct gcagttgaat cttcaatgaa agccttgttg     7620

acagacaagg aaagtcttaa agtaggacca ctggacagtg taacgtatct ggacaaaatt     7680

aaaaaattca tagcatccat agaaaaagag aaagattctt taggcaactt gaaaatcaaa     7740

tgggagaatt tatcaaacca cgtgactgac atggataaga aattgttgga aagccagatt     7800

aagcaacttg aacatggttg ggaacaagtg gaacagcaga ttcaaaagaa gtattctcag     7860

caggtagtgg aatatgatga atttacaacc ctcatgaata aggtacagga cactgagatt     7920

tctctgcaac agcagcagca acatctacag ttaaggctga agtctccaga agaacgggca     7980

gggaaccaaa gcatgattgc cttgaccact gacctccagg ctaccaagca tggattttct     8040

gttttaaagg ggcaagctga acttcagatg aagaggattt ggggagaaaa agaaaagaag     8100

aatttggagg atggaataaa taacttgaag aaacaatggg aaacattgga gccattacac     8160

ttagaagcag aaaatcagat taagaagtgt gacataagga acaagatgaa agagactatc     8220

ttatgggcca agaatttgtt gggtgaactt aatccctcca ttccccttct cccagatgac     8280

attctttcac agatcagaaa gtgcaaagtg acacatgatg gcattctagc taggcagcag     8340

tctgtggaat cgttggctga agaggtcaaa gataaggttc ctagccttac aacctatgag     8400

ggcagtgatt taaataatac cctagaggac ttacggaatc aataccaaat gctggtttta     8460

aaatcaactc aaagatcaca gcaattagaa tttaagttgg aagaaagaag caattttttt     8520

gctataataa ggaagtttca acttatggtt caagaaagtg aaacactgat aattcccagg     8580

gtggagacag ctgccacgga agctgaacta aaacatcacc atgttacttt ggaggcatct     8640

cagaaggaat tgcaagaaat tgacagtgga atctcaacac atcttcagga gctaacaaac     8700

atctatgagg agctgaatgt gtttgaaaga ttatttctgg aagatcagtt gaaaaatctt     8760

aagattagga ccaacagaat acaaagattc attcagaata catgtaatga agtggaacac     8820

aagataaagt tttgcagaca attccatgaa aaaacatcag cgcttcagga ggaggctgac     8880

agtatacagc gcaatgaact attacttaat caagaagtaa ataaaggtgt taaagaggag     8940

atctataatc ttaaagacag actcaccgct attaagtgtt gcatcttaca ggtattgaaa     9000

cttaaaaaag tgtttgacta tattggacta aactgggatt tttcacaact tgaccaatta     9060

caaacccaag tatttgaaaa agaaaaggaa cttgaagaaa aaattaagca gttggacaca     9120

tttgaggaag aacatggcaa atatcaggca ttattaagta aaatgagagc tattgatttg     9180

caaattaaga aaatgactga agtagtacta aaagctcctg atagctctcc ggaaagcaga     9240

cggctcaatg cccaaatttt aagtcagaga attgagaaag ccaagtgttt atgtgatgag     9300

ataataaaga aattaaatga aaataagacc tttgatgact cattcaagga gaaagaaata     9360

ctacaaataa agctgaatgc agaagaaaat gataagttat acaaagttct ccaaaacatg     9420

gtattagaac tctcaccaaa agaattggat gaaaagaatt gtcaggacaa actagaaact     9480

tccttacatg ttttaaatca gataaaatct caattacagc agccattact tataaatttg     9540

gaaattaaac atattcaaaa tgaaaaggac aattgtgaag catttcagga gcaagtttgg     9600

gcagaaatgt gtagtattaa agctgtgact gctattgaga aacaaagaga agaaaactct     9660

tctgaagcga gtgatgtgga gacaaaacta cgtgagtttg aagatcttca gatgcagctt     9720

aacacaagca ttgatttgcg cacaaatgtc ttgaatgatg cttatgaaaa tctaacacgc     9780

tataaagaag cagtcaccag ggcagtggag agcatcactt ccctcgaagc catcattata     9840

ccctacagag tagatgttgg taatccagaa gaatctttag agatgcctct tcgaaaacaa     9900

gaggaattgg aatccacagt agcacacatc caggacctca ctgagaaact gggaatgata     9960

tccagccccg aagccaaact acaacttcag tatactttac aggaactagt ttctaagaac    10020

tcagcaatga aggaagcttt caaagcacag gaaactgagg cagaaaggta tcttgagaat    10080

tacaaatgct atagaaaaat ggaagaggat atttacacta acctcagcaa aatggagaca    10140

gttcttggac agtccatgtc ctcgttgcca ctgtcttaca gagaagcttt agagcgcttg    10200

gaacagagca aggccttggt gtcaaatctt atatcaacca aagaagagtt aatgaaacta    10260

cgacagatcc ttagactctt gagactcagg tgcacagaaa atgatggcat atgtttgctc    10320

aagattgtgt cggctctgtg ggagaaatgg ctgagtttgc tggaagctgc taaagagtgg    10380

gagatgtggt gcgaagaact gaagcaggaa tggaaatttg tcagtgaaga aattgaacga    10440

gaggcaatta ttttagataa tcttcaggaa gaactccctg aaatttccaa aacaaaagag    10500

gcagccacca cagaggaact ctctgagctg ctagactgtt tatgccaata tggagagaac    10560

gtggagaagc aacagctgtt actgactcta cttcttcagc gcatcagaag tatccagaat    10620

gttcctgaaa gctcaggggc tgtggaaact gttccagcat ttcaagaaat tacttctatg    10680

aaagaacgat gcaacaagct tcttcagaaa gttcagaaaa ataaagaatt ggtgcagact    10740

gaaatccaag aaagacattc cttcacaaaa gagataattg ctttgaagaa tttctttcaa    10800

cagaccacaa cttcattcca aaatatggca ttccaggatc acccagaaaa gtcagaacaa    10860

tttgaggagc ttcaaagcat ccttaagaaa gggaaactaa cttttgagaa tattatggaa    10920

aaactgcgaa tcaagtattc cgaaatgtac accatagtcc ctgcagagat tgaatcccag    10980

gtggaagaat gcagaaaagc tttagaagac atagatgaga agattagcaa tgaagtctta    11040

aaaagctcac catcatatgc aatgaggaga aaaatagaag aaattaacaa tgggcttcat    11100

aatgttgaaa agatgttgca gcagaaaagc aaaaatattg agaaagctca agaaattcaa    11160

aagaaaatgt gggacgagtt agatctatgg cattccaaac taaatgagct ggattctgaa    11220

gttcaggaca ttgttgaaca ggacccagga caggctcaag aatggatgga taacttgatg    11280

attcctttcc agcagtatca gcaagtatca cagagagcag agtgtagaac ctcacagttg    11340

aataaggcca cagttaagat ggaggaatat agtgaccttc tgaagagcac tgaggcttgg    11400

atagaaaata ccagtcattt gctggccaat cctgctgact atgactcttt gaggacactg    11460

agtcaccatg ctagcactgt gcagatggct ttggaagatt cagaacagaa gcacaatctt    11520

ttacattcaa tctttatgga tctagaagac ctgtcaataa tttttgaaac agatgaatta    11580

acccaatcca tacaagagtt aagtaatcaa gtaacagctt tacaacaaaa aataatggaa    11640

agccttccac agattcagcg aatggctgat gatgtggttg ctattgaatc tgaagtaaaa    11700

tcaatggaaa aaagagtttc aaaaatcaaa actatcctat tatcaaaaga aatatttgat    11760

ttttcacctg aagaacatct caaacatggg gaggtcatac ttgaaaatat acgtcccatg    11820

aagaaaacca ttgctgagat agtgtcttac caagtggaac tgaggttgcc ccaaacagga    11880

atgaaacctc tgcctgtgtt tcagcggaca aatcagcttt tacaagatat aaaactattg    11940

gaaaatgtga ctcaagaaca aaatgagtta ttaaaggtag tcataaaaca gaccaatgaa    12000

tgggatgaag aaatagaaaa tttgaaacag atcttaaata attattcagc tcagttctcc    12060

cttgaacata tgtcaccaga ccaagctgac aagctgccac aactacaggg agaaatcgaa    12120

cgtatggaga aacagattct gagtttgaac cagagaaaag aagacctgtt ggtggacttg    12180

aaggccaccg tactaaacct tcaccagcat ttgaagcaag aacaagaagg agtagaaaga    12240

gataggctgc cagctgtaac atcagaggaa ggtggagtgg cagagaggga tgcttctgag    12300

cggaagttga acagaagagg ctccatgtct tacctggcag cagtcgagga agaggtggaa    12360

gaaagttccg tgaagagcga taatggagat gagaaggcag agccatcgcc tcagtcttgg    12420

tcttcacttt ggaagcatga caaggacatg gaagaagaca gagcttcctc atcctctgga    12480

acaattgttc aggaagcata tgggaaaata agcacctctg ataattccat ggcacaaatc    12540

ctcacaccag actcactaaa cactgagcaa ggcccagaat gttccctaag gcccaaccaa    12600

acagaagagg gcaccacacc tcctattgag gctgacactc tggactcttc tgacgcgcaa    12660

ggaggtttgg agcccagggt ggagaaaact aggccggagc ccacagaagt cctgcatgcc    12720

tgcaagaccc aggtggccga gctggagctg tggctgcaac aagccaacgt ggcagttgag    12780

ccggaaacat taaacgcaga catgcagcag gtgctggaac agcagctggt agggtgccag    12840

gctatgctaa cagagattga gcacaaggtt gcctttctgt tagagacttg caaagatcag    12900

ggcctgggag ataatggagc cactcaacat gaggctgaag cgctttccct gaaactgaaa    12960

acagtgaagt gcaatttaga aaaagtccag atgatgcttc aggagaagca cagtgaagat    13020

cagcatccta ccattctaaa gaaatcctca gagccagagc atcaagaagc tctccaacca    13080

gttaaccttt ctgaattgga atccattgta actgaaaggc cacaattcag cagacaaaaa    13140

gatttccagc agcaacaggt tctggagtta aaaccaatgg aacagaaaga tttcatcaaa    13200

ttcatagaat ttaatgctaa gaaaatgtgg ccccagtatt gccaacatga taacgataca    13260

actcaggaat catctgcaag caaccaggca tccagccctg aaaatgacgt tccagactcg    13320

atcttgtcac cccagggcca aaatggagat aagtggcaat atctgcatca tgaactctca    13380

tcaaaaataa agctcccact ccctcagctt gtggagcctc aggtttccac aaatatgggt    13440

attctaccca gcgtgactat gtataacttt agatacccaa caactgaaga actgaaaacc    13500

tataccaccc aacttgaaga cctgcgccaa gaagcaagta accttcagac acaggaaaat    13560

atgacagaag aagcatatat caatttggat aaaaaattgt ttgaactatt cctgaccctc    13620

agtcagtgcc tcagcagtgt ggaggagatg ctggagatgc ccagacttta cagggaggat    13680

ggttctggcc agcaggtgca ctacgagacg ctggctcttg agttgaagaa actttattta    13740

gcgctaagtg acaagaaggg tgatcttttg aaagccatga cttggcctgg cgagaacacc    13800

aacttgctcc ttgaatgttt tgacaacctt caagtctgcc tggagcacac tcaggctgca    13860

gctgtctgta gaagcaagtc cctgaaagct ggcctcgatt acaaccgcag ttaccagaat    13920

gaaataaaga gattatatca tcagctcatt aagagtaaga catctttaca acagtctttg    13980

aatgaaatca gtgggcagag tgttgctgaa cagcttcaga aagcagatgc atatacagtg    14040

gagctggaga acgccgagag ccgagtggcc aaactaagag atgaagggga gaggcttcat    14100

ttaccttatg ctttactcca ggaggtttac aaattagagg atgtacttga cagtatgtgg    14160

ggaatgctaa gagccaggta cacagaactc agcagccctt tcgtcactga gagccagcaa    14220

gatgctttgt tgcaaggcat ggtggaactg gtgaagattg ggaaggaaaa gcttgctcat    14280

ggccacttaa aacaaaccaa aagtaaagtg gcgttacagg ctcaaataga aaatcacaag    14340

gtttttttcc agaagcttgt tgctgacatg ttgttgatcc aagcatactc tgccaaaata    14400

cttccttctt tattgcaaaa cagagagaca ttttgggcag aacaagtaac agaagttaaa    14460

atactagaag aaaagtcacg ccaatgtggt atgaagctgc agagtttgtt gcagaaatgg    14520

gaagaatttg atgaaaacta tgcatctctt gaaaaggacc tggaaattct tatatctaca    14580

ttgccctctg tgagtttggt ggaagaaaca gaggaaagat tagtggaaag gatttcattt    14640

taccagcaaa taaaaagaaa cattggtgga aaacacgccc ggctttacca aactctgaac    14700

gaaggcaaac agttggtggc gtctgtgagc tgtcctgaat tagagggcca gatcgcaaaa    14760

ctggaagagc agtggttgtc cctgaacaag aaaattgacc atgagctcca caggctgcaa    14820

gctcttctca agcatctgct cagttataac agagattcgg atcagttaac caagtggttg    14880

gaatcttccc agcatactct gaattactgg aaagaacagt ccctcaatgt gtctcaggac    14940

ttggatacaa tcagaagcaa catcaacaat ttttttgagt tttcaaaaga agttgatgaa    15000

aaatcctcct tgaagactgc cgttatcagt atcgggaacc agcttcttca cctgaaagaa    15060

actgatacag ctacactgag agcttcttta gcacagtttg aacaaaaatg gacaatgctc    15120

ataactcaac ttccagatat tcaagaaaaa cttcaccagc ttcaaatgga gaaattgccg    15180

tctcgtaaag caatcacaga aatgattagc tggatgaaca atgtggagca tcaaacttca    15240

gatgaagact ccgtgcattc accaagttct gcatctcaag ttaaacatct tcttcagaag    15300

cacaaggagt ttagaatgga aatggactat aaacagtgga tagttgactt cgttaaccag    15360

tcattacttc agctaagcac ctgtgatgta gaaagcaagc gctatgaaag aacggagttt    15420

gcagagcacc tgggggagat gaaccgccag tggcaccgtg tacatggaat gctgaataga    15480

aagatacaac atttagaaca acttctagaa agtatcactg agagtgaaaa taaaatacag    15540

atcttgaaca actggctgga agcacaagaa gagagactga aaactttaca aaaacctgaa    15600

agtgtgatct cagtgcagaa gctgctcctg gactgtcagg atatagaaaa tcaacttgca    15660

attaaatcca aagcactaga tgagttgaaa caaagttatc tgactttgga gagtggggca    15720

gtgccattgt tagaagatac agcatcccga attgatgagt tatttcaaaa gagaagcagt    15780

gttctcactc aggtcaatca gctcaaaacc tccatgcagt cagttttaca ggagtggaag    15840

atttatgatc aactctatga tgaagtgaat atgatgacaa tccgattctg gtactgcatg    15900

gaacacagca agcctgtggt gttatcattg gagaccttga gatgccaggt ggagaacctt    15960

cagtctctgc aagatgaagc tgagagcagt gaagggagtt gggagaaact ccaggaggtt    16020

atcggcaaac tcaaaggtct ctgcccctct gttgctgaaa taatcgaaga gaaatgccaa    16080

aatactcata aaaggtggac tcaggtgaac caagccattg cagaccagtt gcagaaggcc    16140

cagagtctgc tccagctctg gaaggcctat agcaatgctc atggtgaagc tgccgcaagg    16200

ctgaagcagc aggaagcaaa gtttcaacag ctcgcaaaca tcagcatgtc tggaaacaac    16260

ctggcagaga tcctgccccc agccctgcag gacataaagg agctgcagca tgatgtgcag    16320

aaaacaaaag aagcctttct ccaaaattcc agtgtcctgg atcgactccc acaacccgca    16380

gagtccagca cccacatgct cctcccgggc cccctgcact ctctccagag ggctgcttat    16440

ttggaaaaga tgctgcttgt gaaagcaaat gaatttgagt ttgttctctc acagtttaag    16500

gattttggag tccggctgga atctttaaaa ggtcttatta tgcatgaaga agagaatttg    16560

gatagacttc accaacagga aaaagaaaat cctgactcat tcctgaatca tgtgctggca    16620

ctgacagccc aatcacctga tattgaacat ttgaatgaag tgagcctcaa gctcccactt    16680

agtgacgtag ctgtgaagac gttacaaaat atgaaccggc aatggattcg ggccacggcc    16740

acggcactgg agcgctgcag tgagcttcag ggaattggat tgaatgaaaa gtttctttat    16800

tgctgtgaaa agtggatcca acttttggag aagatagaag aagcactcaa agtggatgtg    16860

gctaacagcc ttcctgagct cctggagcag cagaaaacct ataagatgtt agaagctgaa    16920

gtttctataa accagacaat tgctgattcc tatgtcaccc agtccttaca actcctggac    16980

acaacagaaa tagagaacag accagaattt attacagaat tctcaaagct gacggatcgg    17040

tggcagaatg ctgtccaggg tgttcggcag aggaagggtg acgttgatgg gctggtgagg    17100

cagtggcaag atttcactac ttctgtggag aacttgtttc gcttcctcac tgacaccagc    17160

cacctgctat ctgcagtgaa gggccaggag cgcttcagcc tctaccaaac cagaagtctg    17220

atccatgagc tgaagaataa agaaattcat tttcaaagga ggcgaactac ctgtgcccta    17280

accttggaag ctggagaaaa gttactgctc acaactgacc tgaaaactaa agagtctgtg    17340

ggtaggagaa tcagtcaact tcaggacagc tggaaagaca tggagcccca gctggcagag    17400

atgattaagc agttccagag cactgtagag acctgggacc agtgtgaaaa gaaaatcaag    17460

gagttgaaaa gcaggctgca agttttaaag gcacaaagtg aagatcctct tccagagctt    17520

cacgaggacc tccataacga aaaagagctg attaaggaac tagaacagtc tttggctagc    17580

tggactcaga acttgaaaga acttcaaact atgaaggcgg acttaacccg gcacgttctc    17640

gtggaagatg tgatggtttt gaaggagcaa atagagcatt tgcacagaca atgggaggac    17700

ctctgcttaa gggtggccat acgtaaacag gagattgaag acagactcaa tacatgggtt    17760

gtattcaatg aaaaaaataa agagttgtgt gcctggctgg tgcagatgga aaacaaagtt    17820

ctacagacag cggacattag tattgaagaa atgattgaaa agttacagaa ggactgcatg    17880

gaagaaataa acttgtttag tgaaaacaag ttacagttaa agcagatggg tgaccagttg    17940

atcaaggcca gcaacaaatc aagagcagct gagatcgatg acaagctcaa caaaattaac    18000

gatcgttggc aacatctttt tgatgtcatc ggatcaaggg tgaagaagct gaaggagacc    18060

tttgctttta ttcagcagtt ggacaaaaac atgagcaacc ttcgcacctg gttggctcga    18120

attgagtctg agctttccaa gcctgttgtt tatgatgtct gcgatgatca agagatccag    18180

aagaggctcg ctgagcagca ggatctacag cgagatattg aacaacacag cgcaggggtg    18240

gagtccgtgt ttaacatctg tgacgtccta ctgcacgact ccgatgcctg tgcaaatgag    18300

accgagtgtg actcgatcca gcagaccacc aggagcctgg acagacgctg gaggaacatt    18360

tgtgccatgt ccatggagcg gcgcatgaaa atcgaggaga cgtggcgcct gtggcagaag    18420

tttttagacg actattctcg ctttgaggac tggctcaagt cagctgagag gacggcagcc    18480

tgcccaaatt cctcagaggt gttgtacacg agtgccaaag aggaactgaa gaggtttgag    18540

gcctttcagc ggcagattca tgagcggctc actcagctgg agctcatcaa caagcagtac    18600

cggcggctgg cccgggagaa ccgcacagac acggccagca ggctgaagca gatggtccac    18660

gagggcaacc agcgctggga caaccttcag aggcgggtca cagccgtcct gcggagactc    18720

aggcatttca ccaaccagag ggaagaattt gagggcacca gggagagcat tctggtgtgg    18780

ctcacagaga tggacctgca gctgaccaac gtggagcact tctcagagag tgacgccgat    18840

gacaagatgc gccaactgaa tggcttccaa caggaaatta cattaaatac caacaagatt    18900

gatcagctca ttgtgtttgg ggagcagctg attcagaaga gcgagcccct ggatgctgtg    18960

ctgattgagg atgagctgga ggaactccac cgctactgcc aggaggtgtt tggaagggtc    19020

tcccggttcc accggcggct cacctcctgc actccgggct tggaagatga aaaggaggcc    19080

tctgagaatg aaacagacat ggaagacccc agagaaatcc agactgattc ttggcgtaaa    19140

cggggagaga gcgaggaacc gtcatctcct cagtccctgt gtcatctagt ggccccaggg    19200

cacgagcggt ctggctgcga gacccctgtc agcgtggact ccatccccct ggagtgggac    19260

cacacaggcg acgtgggggg ctcctcctct cacgaagagg acgaggaggg cccatactac    19320

agcgcactgt caggtaaatc catttcggat ggccactcgt ggcatgttcc cgacagccct    19380

tcctgtcccg agcatcacta caagcaaatg gaaggtgaca ggaatgttcc acctgttccc    19440

cctgcgtcca gcacccctta taaaccaccc tatggaaagc tactattacc tccaggcacg    19500

gatggtggca aagaaggccc gcgagtcctg aatggcaacc cacagcagga agacggggga    19560

ctggccggta tcacagagca gcagtcaggt gccttcgaca gatgggagat gattcaagca    19620

caggagcttc acaataagct caaaataaaa caaaatttgc aacagctgaa ctctgatatc    19680

agcgccatca ctacttggct gaaaaaaact gaagcagagc tggaaatgtt aaagatggca    19740

aagcctccct ctgatatcca ggaaatagaa ctgagagtga agagactgca ggagatactg    19800

aaagcctttg acacttacaa ggcattagtg gtctctgtca acgtgagcag caaggaattt    19860

ctgcaaaccg agagccccga atccacagag ctccaaagta gactccgcca gctgagcctg    19920

ctctgggaag cagcacaggg cgcagtggac agctggagag ggggcttacg acagtcgctc    19980

atgcagtgcc aggacttcca ccagttgagt caaaatctgc tgctgtggtt agcgagtgcc    20040

aagaaccgga ggcagaaggc tcatgtcacc gatccaaagg cagacccccg ggctctccta    20100

gagtgtcgga gggaactaat gcaactggaa aaggagctgg tagaacgtca acctcaagtg    20160

gacatgttac aggagatttc aaacagcctt ctcattaagg gacatggaga agactgtatt    20220

gaagctgaag aaaaggtgca tgttattgag aagaaactca aacagttacg ggagcaagtg    20280

tcccaagatt taatggcctt gcagggaacc cagaacccag cctcacccct gcccagcttc    20340

gacgaggtag actcggggga ccagcctcct gcaacatccg tgccagctcc ccgagcaaag    20400

cagttcagag cagtgagaac tacagaaggc gaggaggaga cagagagcag ggtccccggc    20460

agcacacggc cacagcgctc cttcctctca agggtggtcc gggcagccct acccctgcag    20520

ctgctcctcc tgctgctgct gctcctggcc tgcctgctgc cctcctccga agaagactac    20580

agctgcactc aggccaacaa ctttgcccgg tccttttacc ccatgctgag gtacaccaat    20640

gggccacccc ccacatag                                                  20658


<210>  166
<211>  2370
<212>  DNA
<213>  Homo sapiens

<400>  166
atgacatcct ttcaagaagt cccattgcag acttccaact ttgcccatgt catctttcaa       60

aatgtggcca agagttacct tcctaatgca cacctggaat gtcattacac cttaactcca      120

tatattcatc cacatccaaa agattgggtt ggtatattca aggttggatg gagtactgct      180

cgtgattatt acacgttttt atggtcccct atgcctgaac attatgtgga aggatcaaca      240

gtcaattgtg tactagcatt ccaaggatat taccttccaa atgatgatgg agaattttat      300

cagttctgtt acgttaccca taagggtgaa attcgtggag caagtacacc tttccagttt      360

cgagcttctt ctccagttga agagctgctt actatggaag atgaaggaaa ttctgacatg      420

ttagtggtga ccacaaaagc aggccttctt gagttgaaaa ttgagaaaac catgaaagaa      480

aaagaagaac tgttaaagtt aattgccgtt ctggaaaaag aaacagcaca acttcgagaa      540

caagttggga gaatggaaag agaacttaac catgagaaag aaagatgtga ccaactgcaa      600

gcagaacaaa agggtcttac tgaagtaaca caaagcttaa aaatggaaaa tgaagagttt      660

aagaagaggt tcagtgatgc tacatccaaa gcccatcagc ttgaggaaga tattgtgtca      720

gtaacacata aagcaattga aaaagaaacc gaattagaca gtttaaagga caaactcaag      780

aaggcacaac atgaaagaga acaacttgaa tgtcagttga agacagagaa ggatgaaaag      840

gaactttata aggtacattt gaagaataca gaaatagaaa ataccaagct tatgtcagag      900

gtccagactt taaaaaattt agatgggaac aaagaaagcg tgattactca tttcaaagaa      960

gagattggca ggctgcagtt atgtttggct gaaaaggaaa atctgcaaag aactttcctg     1020

cttacaacct caagtaaaga agatacttgt tttttaaagg agcaacttcg taaagcagag     1080

gaacaggttc aggcaactcg gcaagaagtt gtctttctgg ctaaagaact cagtgatgct     1140

gtcaacgtac gagacagaac gatggcagac ctgcatactg cacgcttgga aaacgagaaa     1200

gtgaaaaagc agttagctga tgcagtggca gaacttaaac taaatgctat gaaaaaagat     1260

caggacaaga ctgatacact ggaacacgaa ctaagaagag aagttgaaga tctgaaactc     1320

cgtcttcaga tggctgcaga ccattataaa gaaaaattta aggaatgcca aaggctccaa     1380

aaacaaataa acaaactttc agatcaatca gctaataata ataatgtctt cacaaagaaa     1440

acggggaatc agcagaaagt gaatgatgct tcagtaaaca cagacccagc cacttctgcc     1500

tctactgtag atgtaaagcc atcaccttct gcagcagagg cagattttga catagtaaca     1560

aaggggcaag tctgtgaaat gaccaaagaa attgctgaca aaacagaaaa gtataataaa     1620

tgtaaacaac tcttgcagga tgagaaagca aaatgcaata aatatgctga tgaacttgca     1680

aaaatggagc tgaaatggaa agaacaagtg aaaattgctg aaaatgtaaa acttgaacta     1740

gctgaagtac aggacaatta taaagaactt aaaaggagtc tagaaaatcc agcagaaagg     1800

aaaatggaag gtcagaattc ccagagtcct caatgtttca aaacatgctc agagcaaaat     1860

ggttatgttc tcacattgtc aaatgcacaa ccagttctgc aatatggtaa tccttatgca     1920

tctcaggaaa caagagatgg agcagatggt gctttttacc cagatgaaat acaaaggcca     1980

cctgtcagag tcccctcttg gggactggaa gacaatgttg tctgcagcca gcctgctcga     2040

aactttagtc ggcctgatgg cttagaggac tctgaggata gcaaagaaga tgagaatgtg     2100

cctactgctc ctgatcctcc aagtcaacat ttacgtgggc atgggacagg cttttgcttt     2160

gattccagct ttgatgttca caagaagtgt cccctctgtg agttaatgtt tcctcctaac     2220

tatgatcaga gcaaatttga agaacatgtt gaaagtcact ggaaggtgtg cccgatgtgc     2280

agcgagcagt tccctcctga ctatgaccag caggtgtttg aaaggcatgt gcagacccat     2340

tttgatcaga atgttctaaa ttttgactag                                      2370


<210>  167
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  167
atggccccct ttgagcccct ggcttctggc atcctgttgt tgctgtggct gatagccccc       60

agcagggcct gcacctgtgt cccaccccac ccacagacgg ccttctgcaa ttccgacctc      120

gtcatcaggg ccaagttcgt ggggacacca gaagtcaacc agaccacctt ataccagcgt      180

tatgagatca agatgaccaa gatgtataaa gggttccaag ccttagggga tgccgctgac      240

atccggttcg tctacacccc cgccatggag agtgtctgcg gatacttcca caggtcccac      300

aaccgcagcg aggagtttct cattgctgga aaactgcagg atggactctt gcacatcact      360

acctgcagtt ttgtggctcc ctggaacagc ctgagcttag ctcagcgccg gggcttcacc      420

aagacctaca ctgttggctg tgaggaatgc acagtgtttc cctgtttatc catcccctgc      480

aaactgcaga gtggcactca ttgcttgtgg acggaccagc tcctccaagg ctctgaaaag      540

ggcttccagt cccgtcacct tgcctgcctg cctcgggagc cagggctgtg cacctggcag      600

tccctgcggt cccagatagc ctga                                             624


<210>  168
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  168
atggctacgc ccctggtggc gggtcccgca gctctacgct tcgccgccgc ggctagctgg       60

caggttgtgc gcggacgctg cgtggaacat tttccgcgag tactggagtt tctgcgatct      120

ctgcgcgctg ttgcccctgg cttggttcgc taccggcacc acgaacgcct ttgtatgggc      180

ctaaaggcca aggtggtggt ggagctgatc ctgcagggcc ggccttgggc ccaagtcctg      240

aaagccctga atcaccactt tccagaatct ggacctatag tgcgggatcc caaggctaca      300

aagcaggatc tgaggaagat tttggaggca caggaaactt tttaccagca ggtgaagcag      360

ctgtcagagg ctcctgtgga tttggcctcg aagctgcagg aacttgaaca agagtatggg      420

gaaccctttc tggctgccat ggaaaagctg ctttttgagt acttgtgtca gctggagaaa      480

gcactgccta caccgcaggc acagcagctt caggatgtgc tgagttggat gcagcctgga      540

gtctctatca cctcttctct tgcctggaga caatatggtg tggacatggg gtggctgctt      600

ccagagtgct ctgttactga ctcagtgaac ctggctgagc ccatggaaca gaatcctcct      660

cagcaacaaa gactagcact ccacaatccc ctgccaaaag ccaagcctgg cacacatctt      720

cctcagggac catcttcaag gacgcaccca gaacctctag ctggccgaca cttcaatctg      780

gcccctctag gccgacgaag agttcagtcc caatgggcct ccactagggg aggccataag      840

gagcgcccca cagtcatgct gtttcccttt aggaatctcg gctcaccaac ccaggtcata      900

tctaagcctg agagcaagga agaacatgcg atatacacag cagacctagc catgggcaca      960

agagcagcct ccactgggaa gtctaagagt ccatgccaga ccctgggggg aagggctctg     1020

aaggagaacc cagttgactt gcctgccaca gagcaaaagg agtga                     1065


<210>  169
<211>  2577
<212>  DNA
<213>  Homo sapiens

<400>  169
atgggagacc acctggacct tctcctagga gtggtgctca tggccggtcc tgtgtttgga       60

attccttcct gctcctttga tggccgaata gccttttatc gtttctgcaa cctcacccag      120

gtcccccagg tcctcaacac cactgagagg ctcctgctga gcttcaacta tatcaggaca      180

gtcactgctt catccttccc ctttctggaa cagctgcagc tgctggagct cgggagccag      240

tataccccct tgactattga caaggaggcc ttcagaaacc tgcccaacct tagaatcttg      300

gacctgggaa gtagtaagat atacttcttg catccagatg cttttcaggg actgttccat      360

ctgtttgaac ttagactgta tttctgtggt ctctctgatg ctgtattgaa agatggttat      420

ttcagaaatt taaaggcttt aactcgcttg gatctatcca aaaatcagat tcgtagcctt      480

taccttcatc cttcatttgg gaagttgaat tccttaaagt ccatagattt ttcctccaac      540

caaatattcc ttgtatgtga acatgagctc gagcccctac aagggaaaac gctctccttt      600

tttagcctcg cagctaatag cttgtatagc agagtctcag tggactgggg aaaatgtatg      660

aacccattca gaaacatggt gctggagata ctagatgttt ctggaaatgg ctggacagtg      720

gacatcacag gaaactttag caatgccatc agcaaaagcc aggccttctc tttgattctt      780

gcccaccaca tcatgggtgc cgggtttggc ttccataaca tcaaagatcc tgaccagaac      840

acatttgctg gcctggccag aagttcagtg agacacctgg atctttcaca tgggtttgtc      900

ttctccctga actcacgagt ctttgagaca ctcaaggatt tgaaggttct gaaccttgcc      960

tacaacaaga taaataagat tgcagatgaa gcattttacg gacttgacaa cctccaagtt     1020

ctcaatttgt catataacct tctgggggaa ctttacagtt cgaatttcta tggactacct     1080

aaggtagcct acattgattt gcaaaagaat cacattgcaa taattcaaga ccaaacattc     1140

aaattcctgg aaaaattaca gaccttggat ctccgagaca atgctcttac aaccattcat     1200

tttattccaa gcatacccga tatcttcttg agtggcaata aactagtgac tttgccaaag     1260

atcaacctta cagcgaacct catccactta tcagaaaaca ggctagaaaa tctagatatt     1320

ctctactttc tcctacgggt acctcatctc cagattctca ttttaaatca aaatcgcttc     1380

tcctcctgta gtggagatca aaccccttca gagaatccca gcttagaaca gcttttcctt     1440

ggagaaaata tgttgcaact tgcctgggaa actgagctct gttgggatgt ttttgaggga     1500

ctttctcatc ttcaagttct gtatttgaat cataactatc ttaattccct tccaccagga     1560

gtatttagcc atctgactgc attaagggga ctaagcctca actccaacag gctgacagtt     1620

ctttctcaca atgatttacc tgctaattta gagatcctgg acatatccag gaaccagctc     1680

ctagctccta atcctgatgt atttgtatca cttagtgtct tggatataac tcataacaag     1740

ttcatttgtg aatgtgaact tagcactttt atcaattggc ttaatcacac caatgtcact     1800

atagctgggc ctcctgcaga catatattgt gtgtaccctg actcgttctc tggggtttcc     1860

ctcttctctc tttccacgga aggttgtgat gaagaggaag tcttaaagtc cctaaagttc     1920

tcccttttca ttgtatgcac tgtcactctg actctgttcc tcatgaccat cctcacagtc     1980

acaaagttcc ggggcttctg ttttatctgt tataagacag cccagagact ggtgttcaag     2040

gaccatcccc agggcacaga acctgatatg tacaaatatg atgcctattt gtgcttcagc     2100

agcaaagact tcacatgggt gcagaatgct ttgctcaaac acctggacac tcaatacagt     2160

gaccaaaaca gattcaacct gtgctttgaa gaaagagact ttgtcccagg agaaaaccgc     2220

attgccaata tccaggatgc catctggaac agtagaaaga tcgtttgtct tgtgagcaga     2280

cacttcctta gagatggctg gtgccttgaa gccttcagtt atgcccaggg caggtgctta     2340

tctgacctta acagtgctct catcatggtg gtggttgggt ccttgtccca gtaccagttg     2400

atgaaacatc aatccatcag aggctttgta cagaaacagc agtatttgag gtggcctgag     2460

gatctccagg atgttggctg gtttcttcat aaactctctc aacagatact aaagaaagaa     2520

aaagaaaaga agaaagacaa taacattccg ttgcaaactg tagcaaccat ctcctaa        2577


<210>  170
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  170
atggggtctc agcattccgc tgctgctcgc ccctcctcct gcaggcgaaa gcaagaagat       60

gacagggacg gtttgctggc tgaacgagag caggaagaag ccattgctca gttcccatat      120

gtggaattca ccgggagaga tagcatcacc tgtctcacgt gccaggggac aggctacatt      180

ccaacagagc aagtaaatga gttggtggct ttgatcccac acagtgatca gagattgcgc      240

cctcagcgaa ctaagcaata tgtcctcctg tccatcctgc tttgtctcct ggcatctggt      300

ttggtggttt tcttcctgtt tccgcattca gtccttgtgg atgatgacgg catcaaagtg      360

gtgaaagtca catttaataa gcaagactcc cttgtaattc tcaccatcat ggccaccctg      420

aaaatcagga actccaactt ctacacggtg gcagtgacca gcctgtccag ccagattcag      480

tacatgaaca cagtggtcag tacatatgtg actactaacg tctcccttat tccacctcgg      540

agtgagcaac tggtgaattt taccgggaag gccgagatgg gaggaccgtt ttcctatgtg      600

tacttcttct gcacggtacc tgagatcctg gtgcacaaca tagtgatctt catgcgaact      660

tcagtgaaga tttcatacat tggcctcatg acccagagct ccttggagac acatcactat      720

gtggattgtg gaggaaattc cacagctatt taa                                   753


<210>  171
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  171
atgctcccga acgtcggttc tccacctctt cccttccgaa agtgcccgag cggtgccgga       60

cggactaatc gggcctcggc cgtggctcgg acgtccgctc ccgaaacgcg gcgcggtcgg      120

gccccttcgt caggagacgc gaaaatggcc gaaggagcgc gagcgcgcgg gccgagaggc      180

tgccgggatc gcgacggacc ggcgggcggg gcgggtaaga tggcggcccc gcggcgaggg      240

agaggatcct ccacagtgct ctcttcagtt ccccttcaaa tgctgtttta tctcagcgga      300

acgtactacg ccctgtattt cctcgccacg ctcctgatga tcacgtataa aagtcaggtg      360

ttcagctatc ctcaccgcta cctggtcctc gatcttgctc tgctgtttct gatggggatt      420

ctagaagcag ttcggttata cctgggcacc aggggcaacc tgacagaggc tgagaggccg      480

ctggccgcca gcctggccct cacggctggc accgccctcc tctctgccca cttcctgctt      540

tggcaggccc tagtgttgtg ggcggactgg gccctcagcg ccacgctcct ggcccttcac      600

ggcctggagg ccgtcctgca ggtggttgcc atcgcggcct tcaccaggta g               651


<210>  172
<211>  1038
<212>  DNA
<213>  Homo sapiens

<400>  172
atgcagcttg aaatccaagt agcactaaat tttattattt cgtatttgta caataagctt       60

cccaggagac gtgtcaacat ttttggtgaa gaacttgaaa gacttcttaa gaagaaatat      120

gaagggcact ggtatcctga aaagccatac aaaggatcgg ggtttagatg tatacacata      180

ggggagaaag tggacccagt gattgaacaa gcatccaaag agagtggttt ggacattgat      240

gatgttcgtg gcaatctgcc acaggatctt agtgtttgga tcgacccatt tgaggtttct      300

taccaaattg gtgaaaaggg accagtgaag gtgctttacg tggatgataa taatgaaaat      360

ggatgtgagt tggataagga gatcaaaaac agctttaacc cagaggccca ggtttttatg      420

cccataagtg acccagcctc atcagtgtcc agctctccat cgcctccttt tggtcactct      480

gctgctgtaa gccctacctt catgccccgg tccactcagc ctttaacctt taccactgcc      540

acttttgctg ccaccaagtt cggctctacc aaaatgaaga atagtggccg tagcaacaag      600

gttgcacgta cttctcccat caacctcggc ttgaatgtga atgacctctt gaagcagaaa      660

gccatctctt cctcaatgca ctctctgtat gggcttggct tgggtagcca gcagcagcca      720

cagcaacagc agcagccagc ccagccgcca ccgccaccac caccaccaca gcagcaacaa      780

cagcagaaaa cctctgctct ttctcctaat gccaaggaat ttatttttcc taatatgcag      840

ggtcaaggta gtagtaccaa tggaatgttc ccaggtgaca gcccccttaa cctcagtcct      900

ctccagtaca gtaatgcctt tgatgtgttt gcagcctatg gaggcctcaa tgagaaatct      960

tttgtagatg gcttgaattt tagcttaaat aacatgcagt attctaacca gcaattccag     1020

cctgttatgg ctaactaa                                                   1038


<210>  173
<211>  3750
<212>  DNA
<213>  Homo sapiens

<400>  173
atggccaccg ctgcgactga ggagcccttc ccttttcacg gtctcctgcc gaagaaggag       60

accggagccg cctccttcct ctgccgctac ccggagtatg atgggcgggg ggtgctcatc      120

gcagtcctgg acacgggggt cgacccgggg gctccgggca tgcaggttac aactgatgga      180

aaaccaaaaa tcgttgatat cattgataca acaggaagtg gcgatgtgaa tactgctaca      240

gaagtagagc caaaggatgg tgagattgtt ggcctttcag gaagagtgct taagattcct      300

gcaagctgga caaatccctc aggcaaatat catattggca taaaaaatgg ctatgacttc      360

tatcctaagg cactcaagga aaggatacag aaagaacgga aggaaaaaat ctgggaccct      420

gttcacagag tggcccttgc agaagcctgt agaaaacagg aagaatttga tgttgccaac      480

aacggctctt ctcaagcaaa taaactaatc aaggaggaac ttcaaagtca agtggaattg      540

ctaaattctt ttgagaagaa atacagcgat cctggccctg tatatgactg cttggtatgg      600

catgatggcg aagtctggag agcctgcatt gattctaatg aagatgggga cttgagtaaa      660

tctaccgtgt tgagaaacta caaagaagcc caagaatatg gctcttttgg cacagctgag      720

atgttgaatt actccgttaa tatatacgat gatggaaacc tgctctccat tgtgaccagt      780

ggaggagctc atgggacaca tgtagctagt atagctgctg gacactttcc agaagaacct      840

gaacggaatg gggtagctcc tggtgctcaa attctttcca tcaagattgg tgatacaaga      900

ctaagcacaa tggaaacagg cacaggcctc ataagagcta tgatagaagt tataaatcat      960

aagtgtgatc ttgtcaacta cagttacgga gaagcaactc actggccaaa ttctgggaga     1020

atttgtgaag taattaatga agcagtatgg aagcataata taatttatgt ttcaagtgct     1080

ggaaataatg gtccatgcct gtctacagtt ggttgtccag gtggaactac atcaagtgtg     1140

ataggtgttg gtgcttatgt ttctcctgat atgatggttg ctgagtattc actgagagag     1200

aaattacctg caaatcaata tacttggtct tctagaggac ctagtgctga cggggccctt     1260

ggtgtgagta tcagtgcgcc aggaggagcc attgcttctg ttcctaactg gacactgaga     1320

gggacgcagc tgatgaatgg aacatctatg tcttccccca atgcatgtgg aggcattgcc     1380

ctgatccttt caggtctgaa agctaataac attgactaca cagttcattc agtcagaaga     1440

gctctagaaa acactgcagt gaaggctgac aatatagaag tatttgctca aggacatggt     1500

attattcagg ttgataaagc ctatgactac ctcgttcaga atacatcatt tgctaataaa     1560

ttaggtttta ctgttactgt tggaaataac cgtggcatct acctccgaga tcctgttcag     1620

gtggctgcac cttcagatca tggcgttggc attgaacctg tatttccgga gaacacagaa     1680

aactctgaaa aaatatccct tcagcttcat ttagctctga cttcaaattc atcttgggtt     1740

cagtgtccca gccatttgga actcatgaat caatgtagac acataaacat acgtgtggat     1800

cccaggggct taagagaagg attgcattat acagaggtat gtggctatga tatagcatcc     1860

cctaacgcag gtccgctctt cagagttccg atcactgcag ttatagcagc aaaagtaaat     1920

gaatcatcac attatgatct agcctttaca gatgtacact ttaaacctgg tcaaattcga     1980

aggcatttta ttgaggttcc tgagggtgca acatgggctg aagtgacagt gtgttcgtgt     2040

tcttctgagg tgtcagcaaa gtttgttcta catgcagtcc agcttgtgaa gcaaagagca     2100

tatcgaagcc atgaattcta taagttttgt tctcttccag agaaaggaac actgactgaa     2160

gcttttcctg tcctaggtgg aaaagcaatt gaattttgca ttgctcgttg gtgggcaagt     2220

ctcagtgatg tcaacattga ttataccatt tctttccatg ggatagtgtg tactgctcct     2280

cagttaaaca ttcatgcatc ggaaggaatc aaccgctttg atgttcagtc ctccttgaaa     2340

tacgaagatc tggctccctg cataactttg aagaactggg tccaaacact gcgcccagtg     2400

agtgcaaaaa caaaaccttt aggatcaaga gatgttttgc caaataaccg tcaactttat     2460

gagatggtcc tgacatataa ctttcatcaa cccaagagtg gggaagtaac tccaagctgc     2520

ccactacttt gtgaactatt atatgaatct gaatttgaca gccaactgtg gattattttt     2580

gaccagaaca aaagacagat gggttcaggc gatgcctatc cacatcagta ttctttgaaa     2640

ctggagaaag gagattatac aattcgacta cagattcgcc atgagcaaat cagtgatttg     2700

gaacgcctta aagaccttcc atttattgtt tctcatagat tgtctaatac cttgagctta     2760

gatattcatg aaaatcatag ttttgcactt ctagggaaga agaaatcaag caatttgaca     2820

ttaccaccca aatataacca gccattcttt gttacttcct tacctgatga taaaatacct     2880

aaaggggcag gacctggatg ctatcttgca ggatccttaa cattgtcaaa gactgaacta     2940

ggaaagaaag ctgatgtaat ccctgttcat tactacttaa tacctccacc aacaaagact     3000

aagaatggca gcaaagataa ggaaaaagat tcagaaaaag agaaagattt aaaagaagag     3060

tttactgaag cattacgaga tcttaaaatt cagtggatga caaagctgga ttctagtgac     3120

atttataacg aattgaaaga aacatatcct aattatcttc ctctgtacgt tgcacgactt     3180

catcaattgg atgctgaaaa ggaacgaatg aaaagactta atgaaattgt tgatgcggca     3240

aatgctgtta tttctcatat agatcaaaca gccctagcag tttatattgc aatgaagact     3300

gatcccaggc ctgatgcagc tactataaaa aatgacatgg acaaacaaaa atccaccctc     3360

gtagatgccc tttgtaggaa aggttgtgcc ctggcagacc atcttcttca cacccaggct     3420

caagacggag ccatttccac tgatgcagaa ggaaaggagg aggaaggaga aagtcctttg     3480

gattctctgg cagaaacatt ttgggaaact actaaatgga ctgatctctt tgacaataag     3540

gttttgacat ttgcatataa acatgcatta gtaaataaaa tgtatgggag aggccttaaa     3600

tttgcaacta aacttgtgga agaaaaacca acaaaagaaa actggaaaaa ttgtattcaa     3660

ctgatgaagt tacttggatg gacccattgt gcatctttta ctgaaaactg gctccccatc     3720

atgtatcctc ccgattattg cgtattctaa                                      3750


<210>  174
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  174
atgcctcctc agcttcaaga aactagaatg aaccgaagca ttcctgtgga ggttgatgaa       60

tcagaaccat acccaagtca gttgctgaaa ccaatcccag aatattcccc ggaagaggaa      120

tcagaaccac ctgctccaaa tataaggaac atggcaccca acagcttgtc tgcacccaca      180

atgcttcaca attcctccgg agacttttct caagctcact caaccctgaa acttgcaaat      240

caccagcggc ctgtatcccg gcaggtcacc tgcctgcgca ctcaagttct ggaggacagt      300

gaagacagtt tctgcaggag acacccaggc ctgggcaaag ctttcccttc tgggtgctct      360

gcagtcagcg agcctgcgtc tgagtctgtg gttggagccc tccctgcaga gcatcagttt      420

tcatttatgg aaaaacgtaa tcaatggctg gtatctcagc tttcagcggc ttctcctgac      480

actggccatg actcagacaa atcagaccaa agtttaccta atgcctcagc agactccttg      540

ggcggtagcc aggagatggt gcaacggccc cagcctcaca ggaaccgagc aggcctggat      600

ctgccaacca tagacacggg atatgattcc cagccccagg atgtcctggg catcaggcag      660

ctggaaaggc ccctgcccct cacctccgtg tgttaccccc aggacctccc cagacctctc      720

aggtccaggg agttccctca gtttgaacct cagaggtatc cagcatgtgc acagatgctg      780

cctcccaatc tttccccaca tgctccatgg aactatcatt accattgtcc tggaagtccc      840

gatcaccagg tgccatatgg ccatgactac cctcgagcag cctaccagca agtgatccag      900

ccggctctgc ctgggcagcc cctgcctgga gccagtgtga gaggcctgca ccctgtgcag      960

aaggttatcc tgaattatcc cagcccctgg gaccacgaag agaggcccgc acagagagac     1020

tgctcctttc cggggcttcc aaggcaccag gaccagccac atcaccagcc acctaataga     1080

gctggtgctc ctggggagtc cttggagtgc cctgcagagc tgagaccaca ggttccccag     1140

cctccgtccc cagctgctgt gcctagaccc cctagcaacc ctccagccag aggaactcta     1200

aaaacaagca atttgccaga agaattgcgg aaagtcttta tcacttattc gatggacaca     1260

gctatggagg tggtgaaatt cgtgaacttt ttgttggtaa atggcttcca aactgcaatt     1320

gacatatttg aggatagaat ccgaggcatt gatatcatta aatggatgga gcgctacctt     1380

agggataaga ccgtgatgat aatcgtagca atcagcccca aatacaaaca ggacgtggaa     1440

ggcgctgagt cgcagctgga cgaggatgag catggcttac atactaagta cattcatcga     1500

atgatgcaga ttgagttcat aaaacaagga agcatgaatt tcagattcat ccctgtgctc     1560

ttcccaaatg ctaagaagga gcatgtgccc acctggcttc agaacactca tgtctacagc     1620

tggcccaaga ataaaaaaaa catcctgctg cggctgctga gagaggaaga gtatgtggct     1680

cctccacggg ggcctctgcc cacccttcag gtggttccct tgtga                     1725


<210>  175
<211>  1563
<212>  DNA
<213>  Homo sapiens

<400>  175
atggagtgtc cacacctgag ctccagcgtc tgcattgctc cggactcagc caagttcccc       60

aacggctccc cgtcgtcctg gtgctgcagc gtgtgccggt ccaacaaaag cccttgggtc      120

tgtttgactt gttcaagtgt ccactgtgga aggtatgtga atggccatgc aaaaaaacat      180

tatgaagatg cacaagtacc tttaaccaac cataagaaat cagaaaagca agataaagtt      240

cagcacacag tatgtatgga ttgcagtagc tacagtacat actgttatcg ctgtgatgat      300

tttgtggtta atgacaccaa gctgggactg gtacagaaag tcagagaaca cttacagaac      360

ttggaaaact cagctttcac agctgacagg cataagaaaa gaaaactttt ggaaaactca      420

acactaaaca gcaagttatt aaaagtaaat ggaagcacca ctgccatttg tgccacaggc      480

cttcggaatt tggggaacac atgtttcatg aatgccatcc ttcagtcact cagtaacatt      540

gagcagtttt gctgttattt caaagaactg cccgccgtgg agttaaggaa tgggaaaaca      600

gcaggaaggc ggacatacca caccaggagc caaggggata acaatgtgtc tttggtagaa      660

gagtttagaa agacactctg tgctttatgg caaggcagcc agactgcatt tagcccagag      720

tccttatttt atgttgtttg gaagattatg ccaaacttta ggggctatca acagcaggac      780

gcccatgaat tcatgcgcta ccttttggac cacctacact tggaacttca gggcggtttc      840

aacggtgttt cccgctcagc aattctgcag gagaattcta ctctgtctgc aagtaacaag      900

tgttgcataa atggagcatc tactgttgtc acggctatat tcggaggcat tctccaaaat      960

gaggttaact gcctcatatg tgggacagaa tctagaaagt ttgatccatt cctagacctt     1020

tcattagata ttccaagtca gttcagaagt aagcgctcta agaatcaaga aaatggacca     1080

gtttgttcgt tacgagattg tcttcgcagt tttaccgact tagaagaact tgatgagaca     1140

gagttatata tgtgccataa atgcaaaaag aaacaaaagt ccacaaaaaa gttttggatt     1200

caaaaactac ccaaggtgct atgcttacat ttgaaaagat ttcattggac agcatattta     1260

agaaataaag ttgatacata cgtagaattt ccactgagag gcctagacat gaaatgctac     1320

ttactagagc ctgagaacag tggcccggag agctgcctgt atgacctcgc cgctgtggtg     1380

gtgcaccatg gttccggggt tggttctgga cattacacag catacgcaac tcacgaaggc     1440

cgctggttcc acttcaatga cagtactgta acactgactg acgaggagac tgtggtgaag     1500

gcgaaggcct acatcctttt ctacgtggaa caccaggcca aagctggatc ggataaactt     1560

taa                                                                   1563


<210>  176
<211>  2538
<212>  DNA
<213>  Homo sapiens

<400>  176
atggagctgt ggcgccaatg cacccactgg ctcatccagt gccgggtgct gccgcccagc       60

caccgcgtga cctgggatgg ggctcaggtg tgtgaactgg cccaggccct ccgggatggt      120

gtccttctgt gtcagctgct taacaacctg ctaccccatg ccatcaacct gcgtgaggtc      180

aacctgcgcc cccagatgtc ccagttcctg tgccttaaga acattagaac cttcctgtcc      240

acctgctgtg agaagttcgg cctcaagcgg agcgagctct tcgaagcctt tgacctcttc      300

gatgtgcagg attttggcaa ggtcatctac accctgtctg ctctgtcctg gaccccgatc      360

gcccagaaca gggggatcat gcccttcccc accgaggagg agagtgtagg tgatgaagac      420

atctacagtg gcctgtccga ccagatcgac gacacggtgg aggaggatga ggacctgtat      480

gactgcgtgg agaatgagga ggcggaaggc gacgagatct atgaggacct catgcgctcg      540

gagcccgtgt ccatgccgcc caagatgaca gagtatgaca agcgctgctg ctgcctgcgg      600

gagatccagc agacggagga gaagtacact gacacgctgg gctccatcca gcagcatttc      660

ttgaagcccc tgcaacggtt cctgaaacct caagacattg agatcatctt tatcaacatt      720

gaggacctgc ttcgtgttca tactcacttc ctaaaggaga tgaaggaagc cctgggcacc      780

cctggcgcag ccaatctcta ccaggtcttc atcaaataca aggagaggtt cctcgtctat      840

ggccgctact gcagccaggt ggagtcagcc agcaaacacc tggaccgtgt ggccgcagcc      900

cgggaggacg tgcagatgaa gctggaggaa tgttctcaga gagccaacaa cgggaggttc      960

accctgcggg acctgctgat ggtgcctatg cagcgagttc tcaaatatca cctccttctc     1020

caggagctgg tgaaacacac gcaggaggcg atggagaagg agaacctgcg gctggccctg     1080

gatgccatga gggacctggc tcagtgcgtg aacgaggtca agcgagacaa cgagacactg     1140

cgacagatca ccaatttcca gctgtccatt gagaacctgg accagtctct ggctcactat     1200

ggccggccca agatcgacgg ggaactcaag atcacctcgg tggaacggcg ctccaagatg     1260

gacaggtatg ccttcctgct cgacaaagct ctactcatct gtaagcgcag gggagactcc     1320

tatgacctca aggactttgt aaacctgcac agcttccagg ttcgggatga ctcttcagga     1380

gaccgagaca acaagaagtg gagccacatg ttcctcctga tcgaggacca aggtgcccag     1440

ggctatgagc tgttcttcaa gacaagagaa ttgaagaaga agtggatgga gcagtttgag     1500

atggccatct ccaacatcta tccggagaat gccaccgcca acgggcatga cttccagatg     1560

ttctcctttg aggagaccac atcctgcaag gcctgtcaga tgctgcttag aggtaccttc     1620

tatcagggct accgctgcca tcggtgccgg gcatctgcac acaaggagtg tctggggagg     1680

gtccctccat gtggccgaca tgggcaagat ttcccaggaa ctatgaagaa ggacaaacta     1740

catcgcaggg ctcaggacaa aaagaggaat gagctgggtc tgcccaagat ggaggtgttt     1800

caggaatact acgggcttcc tccaccccct ggagccattg gaccctttct acggctcaac     1860

cctggagaca ttgtggagct cacgaaggct gaggctgaac agaactggtg ggagggcaga     1920

aatacatcta ctaatgaaat tggctggttt ccttgtaaca gggtgaagcc ctatgtccat     1980

ggccctcctc aggacctgtc tgttcatctc tggtacgcag gccccatgga gcgggcaggg     2040

gcagagagca tcctggccaa ccgctcggac gggactttct tggtgcggca gagggtgaag     2100

gatgcagcag aatttgccat cagcattaaa tataacgtcg aggtcaagca cattaaaatc     2160

atgacagcag aaggactgta ccggatcaca gagaaaaagg ctttccgggg gcttacggag     2220

ctggtggagt tttaccagca gaactctcta aaggattgct tcaagtctct ggacaccacc     2280

ttgcagttcc ccttcaagga gcctgaaaag agaaccatca gcaggccagc agtgggaagc     2340

acaaagtatt ttggcacagc caaagcccgc tatgacttct gcgcccgaga ccgatcagag     2400

ctgtcgctca aggagggtga catcatcaag atccttaaca agaagggaca gcaaggctgg     2460

tggcgagggg agatctatgg ccgggttggc tggttccctg ccaactacgt ggaggaagat     2520

tattctgaat actgctga                                                   2538


<210>  177
<211>  4011
<212>  DNA
<213>  Homo sapiens

<400>  177
atggctacag aaattggttc tcctcctcgt tttttccata tgccaaggtt ccagcaccag       60

gcacctcgac agctgtttta taagcgacct gattttgcac aacagcaagc aatgcaacag      120

cttacttttg atggaaaacg aatgagaaaa gctgtgaacc gaaaaaccat agactacaat      180

ccatctgtaa ttaagtattt ggagaacaga atatggcaaa gagaccagag agatatgcgg      240

gcaattcagc ctgatgcagg ttattacaat gatctggtcc cacctatagg aatgttgaat      300

aatcctatga atgcagtaac aacaaaattt gttcggacat caacaaataa agtaaagtgt      360

cctgtatttg ttgttaggtg gactccagaa ggaagacgct tggtcactgg agcttctagt      420

ggggagttta ccctgtggaa tggactcact ttcaattttg aaacaatatt acaggctcac      480

gacagcccag tgagggccat gacgtggtca cataatgaca tgtggatgtt gacagcagac      540

cacggaggat atgtgaaata ttggcagtcg aacatgaaca acgtcaagat gttccaggca      600

cataaggagg cgattagaga ggccagtttc tcacccacgg ataataaatt tgctacatgc      660

tctgatgacg gcactgttag aatctgggac tttcttcgtt gccatgagga aagaattctc      720

cgagggcatg gtgctgatgt gaaatgtgta gactggcatc caaccaaagg gttagttgtt      780

tcaggaagta aagatagtca acagccaatc aagttctggg atcccaagac tgggcagagt      840

cttgcaacac ttcatgccca taaaaacaca gtaatggaag tgaaattaaa cctcaatggc      900

aattggctac tcacagcatc acgtgatcat ctctgtaaac tttttgatat cagaaaccta      960

aaagaagagc ttcaagtctt ccgaggtcat aagaaagaag ccacagctgt ggcctggcat     1020

cctgttcatg aaggactttt tgccagtgga gggtctgatg gttctttgtt attctggcat     1080

gttggggtag agaaggaagt gggtgggatg gagatggctc acgaagggat gatctggagt     1140

ctggcttggc atcctcttgg gcatattctc tgctcaggct caaatgacca tactagcaaa     1200

ttctggactc gaaaccgacc aggtgataaa atgcgagatc gatataatct aaacctttta     1260

cctggaatgt ctgaagatgg agtagaatat gatgacctcg aacctaatag cctggcagta     1320

attccaggaa tgggaatacc agaacaacta aaattagcta tggaacaaga acagatgggg     1380

aaagatgaat caaatgaaat tgaaatgaca attccaggtt tagattgggg aatggaggaa     1440

gtgatgcaaa aggatcagaa aaaagtacct cagaagaaag ttccttatgc aaaacccatt     1500

cctgctcagt tccagcaggc ttggatgcaa aataaagttc caattcctgc tccaaatgag     1560

gtgctgaatg acagaaaaga agacattaaa ttggaagaga agaaaaaaac acaagcagaa     1620

attgagcaag aaatggctac attacaatat actaacccac aacttctgga gcaacttaaa     1680

attgaaagac ttgcacagaa acaagttgag caaattcagc ctcctccctc atctggcacc     1740

cctctcctcg gaccccagcc ttttccagga caaggtccaa tgtctcagat tcctcaaggt     1800

tttcaacagc cccatccatc tcagcagatg ccaatgaaca tggctcaaat ggggcctcca     1860

ggtccacagg gacagtttag gcctcctgga ccccagggac aaatgggacc acaaggtcct     1920

ccactgcatc agggaggtgg ggggccacaa ggattcatgg gaccacaggg gccccagggc     1980

ccgccccagg ggttgccacg gcctcaggac atgcatgggc cccaaggaat gcagaggcat     2040

cctggacctc atggcccttt gggacctcaa gggccacctg gaccacaagg tagttctggt     2100

cctcaaggtc atatgggtcc tcagggtcca cctggcccac agggtcacat aggcccccaa     2160

ggcccgcctg gccctcaggg tcacttgggc ccacaggggc ctccgggtac tcaaggtatg     2220

cagggaccac ctggtcccag aggaatgcaa gggcctcctc atcctcatgg gatccaaggc     2280

ggaccagggt ctcaagggat ccaaggtcct gtgtctcagg gacctctgat gggattgaat     2340

ccaagaggaa tgcaggggcc tccaggcccc cgggagaacc agggtcctgc tccccaaggg     2400

atgattatgg gccacccgcc tcaagagatg agaggacctc accctccagg tggactactg     2460

ggacacggcc ctcaggaaat gagaggtcct caggagatcc gaggcatgca ggggcctcca     2520

ccccaaggat caatgctggg acctccccag gaattgcgag ggcctccagg ctcacaaagt     2580

cagcaggggc cgccccaggg ctctttagga cctccacccc agggtggcat gcaaggaccc     2640

cccggacctc agggacagca gaacccagca agagggccac atccatctca agggccaata     2700

ccattccagc aacagaaaac gcctctgcta ggtgatgggc cccgggcccc cttcaaccag     2760

gaaggacaga gcacaggccc cccacccctg ataccaggcc tagggcagca gggagcacaa     2820

ggtcgcattc cccctctgaa ccccggacaa ggacctggcc ccaacaaagg tgactcccgc     2880

ggccctccaa accatcacat gggcccgatg tcagagaggc ggcatgagca gagcggcggg     2940

cctgagcatg ggcccgagag ggggcctttc cggggtggcc aggactgcag gggtccccct     3000

gataggcgtg gccctcaccc agacttcccc gatgacttca gcagaccaga tgacttccac     3060

cctgacaagc gctttggcca ccggttacgt gaatttgagg ggcgaggagg acctttaccg     3120

caagaagaga agtggaggcg agggggccct gggcctccgt ttccccctga tcacagggaa     3180

ttcagcgagg gggatggccg gggtgcagcc cgaggccctc cgggggcatg ggaaggccgc     3240

aggcccggag atgaacgttt cccccgggat cccgaggacc cacgttttcg agggcgcaga     3300

gaagaaagtt tcagaagagg agccccgccg aggcatgagg gccgtgctcc ccccagagga     3360

agggatggtt ttcctggtcc tgaagacttt ggtccagagg agaattttga tgcttctgag     3420

gaagcggccc gaggacgaga tctcagaggt cgaggtcggg gtaccccacg aggaggaagg     3480

aagggtttac ttcccactcc tgacgagttc cctcgctttg aaggagggcg gaagccagat     3540

tcctgggatg gaaacagaga gcctgggcca ggtcatgaac attttcgtga tactccccgc     3600

cctgatcatc cccctcacga cggtcattcc ccagccagca gagaacgctc ctcttctctc     3660

caaggcatgg acatggcatc cctacctccc cgaaagcgcc cctggcatga tggcccaggc     3720

acttctgagc acagagagat ggaggcccca ggaggccctt ctgaagaccg aggaggcaaa     3780

ggccgagggg gcccaggacc tgctcagaga gtgcccaaat ctgggcgttc cagctcctta     3840

gacggagagc accacgatgg ataccacaga gatgaacctt ttgggggccc tccaggcagt     3900

ggcacccctt ctcgaggggg ccggagtggc agtaactggg gtagagggag taacatgaac     3960

tctggcccgc cgaggcgagg agcttcacgg ggtggtggaa ggggtcggta g              4011


<210>  178
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  178
atgggcagaa ttttccttga tcatatcggt ggtacccgtc tgttttcttg tgcaaactgt       60

gatacgatcc tgaccaaccg ctcagaactc atctccactc gtttcacagg cgccactggc      120

agagcatttc tttttaacaa ggtagttaac ctgcagtaca gtgaagttca agatcgggtc      180

atgctcactg gccgccacat ggttcgagat gtgagctgca aaaactgcaa tagcaaactg      240

ggatggatct atgagtttgc cactgaagac agccagcgat ataaggaagg ccgcgtgatc      300

ctggaacgtg ctctagttcg agagagtgag ggctttgagg agcatgtacc atctgataac      360

tcttga                                                                 366


<210>  179
<211>  2412
<212>  DNA
<213>  Homo sapiens

<400>  179
atggactttc cccagcacag ccagcatgtc ttggaacagc tgaaccagca gcggcagctg       60

gggcttctct gtgactgcac ctttgtggtg gacggtgttc actttaaggc tcataaagca      120

gtgctggcgg cctgcagcga gtacttcaag atgctcttcg tggaccagaa ggacgtggtg      180

cacctggaca tcagtaacgc ggcaggcctg gggcaggtgc tggagtttat gtacacggcc      240

aagctgagcc tgagccctga gaacgtggat gatgtgctgg ccgtggccac tttcctccaa      300

atgcaggaca tcatcacggc ctgccatgcc ctcaagtcac ttgctgagcc ggctaccagc      360

cctgggggaa atgcggaggc cttggccaca gaaggagggg acaagagagc caaagaggag      420

aaggtggcca ccagcacgct gagcaggctg gagcaggcag gacgcagcac acccataggc      480

cccagcaggg acctcaagga ggagcgcggc ggtcaggccc agagtgcggc cagcggtgca      540

gagcagacag agaaagccga tgcgccccgg gagccgccgc ctgtggagct caagccagac      600

cccacgagtg gcatggctgc tgcagaagct gaggccgctt tgtccgagag ctcggagcaa      660

gaaatggagg tggagcccgc ccggaaaggg gaagaggagc aaaaggagca agaggagcaa      720

gaggaggagg gcgcagggcc agctgaggtc aaggaggagg gttcccagct ggagaacgga      780

gaggcccccg aggagaacga gaatgaggag tcagcgggca cagactcggg gcaggagctc      840

ggctccgagg cccggggcct gcgctcaggc acctacggcg accgcacgga gtccaaggcc      900

tacggctccg tcatccacaa gtgcgaggac tgtgggaagg agttcacgca cacggggaac      960

ttcaagcggc acatccgcat ccacacgggg gagaagccct tctcgtgccg ggagtgcagc     1020

aaggcctttt ccgacccggc cgcgtgcaag gcccatgaga agacgcacag ccctctgaag     1080

ccctacggct gcgaggagtg cgggaagagc taccgcctca tcagcctgct gaacctgcac     1140

aagaagcggc actcgggcga ggcgcgctac cgctgcgagg actgcggcaa gctcttcacc     1200

acctcgggca acctcaagcg ccaccagctg gtgcacagcg gcgagaagcc ctaccagtgc     1260

gactactgcg gccgctcctt ctccgacccc acttccaaga tgcgccacct ggagacccac     1320

gacacggaca aggagcacaa gtgcccacac tgcgacaaga agttcaacca ggtagggaac     1380

ctgaaggccc acctgaagat ccacatcgct gacgggcccc tcaagtgccg agagtgtggg     1440

aagcagttca ccacctcagg gaacctgaag cggcaccttc ggatccacag cggggagaag     1500

ccctacgtgt gcatccactg ccagcgacag tttgcagacc ccggcgctct gcagcggcac     1560

gtccgcattc acacaggtga gaagccatgc cagtgtgtga tgtgcggtaa ggccttcacc     1620

caggccagct ccctcatcgc ccacgtgcgc cagcacaccg gggagaagcc ctacgtctgc     1680

gagcgctgcg gcaagagatt cgtccagtcc agccagttgg ccaatcatat tcgccaccac     1740

gacaacatcc gcccacacaa gtgcagcgtg tgcagcaagg ccttcgtgaa cgtgggggac     1800

ctgtccaagc acatcatcat tcacactgga gagaagcctt acctgtgtga taagtgtggg     1860

cgtggcttca accgggtaga caacctgcgc tcccacgtga agaccgtgca ccagggcaag     1920

gcaggcatca agatcctgga gcccgaggag ggcagtgagg tcagcgtggt cactgtggat     1980

gacatggtca cgctggctac cgaggcactg gcagcgacag ccgtcactca gctcacagtg     2040

gtgccggtgg gagctgcagt gacagccgat gagacggaag tcctgaaggc cgagatcagc     2100

aaagctgtga agcaagtgca ggaagaagac cccaacactc acatcctcta cgcctgtgac     2160

tcctgtgggg acaagtttct ggatgccaac agcctggctc agcatgtgcg aatccacaca     2220

gcccaggcac tggtcatgtt ccagacagac gcggacttct atcagcagta tgggccaggt     2280

ggcacgtggc ctgccgggca ggtgctgcag gctggggagc tggtcttccg ccctcgcgac     2340

ggggctgagg gccagcccgc actggcagag acctccccta cagctcctga atgtcccccg     2400

cctgccgagt ga                                                         2412


<210>  180
<211>  918
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala 
1               5                   10                  15      


Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Arg 
            20                  25                  30          


Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro 
        35                  40                  45              


Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys 
    50                  55                  60                  


Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu 
65                  70                  75                  80  


Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr 
                85                  90                  95      


Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His 
            100                 105                 110         


Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr 
        115                 120                 125             


Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn 
    130                 135                 140                 


Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu 
145                 150                 155                 160 


Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe 
                165                 170                 175     


Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln 
            180                 185                 190         


Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser 
        195                 200                 205             


Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln 
    210                 215                 220                 


Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala 
                245                 250                 255     


Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser 
            260                 265                 270         


Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys 
        275                 280                 285             


Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met 
    290                 295                 300                 


Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys 
305                 310                 315                 320 


Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala 
                325                 330                 335     


Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly 
            340                 345                 350         


Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly 
        355                 360                 365             


Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe 
    370                 375                 380                 


Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly 
385                 390                 395                 400 


Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly 
                405                 410                 415     


Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys 
            420                 425                 430         


Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys 
        435                 440                 445             


Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln 
    450                 455                 460                 


Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln 
465                 470                 475                 480 


Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr 
                485                 490                 495     


Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr 
            500                 505                 510         


Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu 
        515                 520                 525             


Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val 
    530                 535                 540                 


Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly 
545                 550                 555                 560 


Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln 
                565                 570                 575     


Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile 
            580                 585                 590         


Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr 
        595                 600                 605             


His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly 
    610                 615                 620                 


Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu 
625                 630                 635                 640 


Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys 
                645                 650                 655     


Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys 
            660                 665                 670         


Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly 
        675                 680                 685             


Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val 
    690                 695                 700                 


Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met 
705                 710                 715                 720 


Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser 
                725                 730                 735     


Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val 
            740                 745                 750         


Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln 
        755                 760                 765             


Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg 
    770                 775                 780                 


Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly 
785                 790                 795                 800 


Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg 
                805                 810                 815     


Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg 
            820                 825                 830         


Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val 
        835                 840                 845             


Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala 
    850                 855                 860                 


Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser 
865                 870                 875                 880 


Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala 
                885                 890                 895     


Ala Leu Ala Pro Lys Phe Pro Glu Tyr Arg Ser Gln Arg Ala Gly Gly 
            900                 905                 910         


Met Ile Ser Ser Lys Ile 
        915             


<210>  181
<211>  737
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Asn Gly Asp Ser Arg Ala Ala Val Val Thr Ser Pro Pro Pro Thr 
1               5                   10                  15      


Thr Ala Pro His Lys Glu Arg Tyr Phe Asp Arg Val Asp Glu Asn Asn 
            20                  25                  30          


Pro Glu Tyr Leu Arg Glu Arg Asn Met Ala Pro Asp Leu Arg Gln Asp 
        35                  40                  45              


Phe Asn Met Met Glu Gln Lys Lys Arg Val Ser Met Ile Leu Gln Ser 
    50                  55                  60                  


Pro Ala Phe Cys Glu Glu Leu Glu Ser Met Ile Gln Glu Gln Phe Lys 
65                  70                  75                  80  


Lys Gly Lys Asn Pro Thr Gly Leu Leu Ala Leu Gln Gln Ile Ala Asp 
                85                  90                  95      


Phe Met Thr Thr Asn Val Pro Asn Val Tyr Pro Ala Ala Pro Gln Gly 
            100                 105                 110         


Gly Met Ala Ala Leu Asn Met Ser Leu Gly Met Val Thr Pro Val Asn 
        115                 120                 125             


Asp Leu Arg Gly Ser Asp Ser Ile Ala Tyr Asp Lys Gly Glu Lys Leu 
    130                 135                 140                 


Leu Arg Cys Lys Leu Ala Ala Phe Tyr Arg Leu Ala Asp Leu Phe Gly 
145                 150                 155                 160 


Trp Ser Gln Leu Ile Tyr Asn His Ile Thr Thr Arg Val Asn Ser Glu 
                165                 170                 175     


Gln Glu His Phe Leu Ile Val Pro Phe Gly Leu Leu Tyr Ser Glu Val 
            180                 185                 190         


Thr Ala Ser Ser Leu Val Lys Ile Asn Leu Gln Gly Asp Ile Val Asp 
        195                 200                 205             


Arg Gly Ser Thr Asn Leu Gly Val Asn Gln Ala Gly Phe Thr Leu His 
    210                 215                 220                 


Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Lys Cys Val Val His Ile 
225                 230                 235                 240 


His Thr Pro Ala Gly Ala Ala Val Ser Ala Met Lys Cys Gly Leu Leu 
                245                 250                 255     


Pro Ile Ser Pro Glu Ala Leu Ser Leu Gly Glu Val Ala Tyr His Asp 
            260                 265                 270         


Tyr His Gly Ile Leu Val Asp Glu Glu Glu Lys Val Leu Ile Gln Lys 
        275                 280                 285             


Asn Leu Gly Pro Lys Ser Lys Val Leu Ile Leu Arg Asn His Gly Leu 
    290                 295                 300                 


Val Ser Val Gly Glu Ser Val Glu Glu Ala Phe Tyr Tyr Ile His Asn 
305                 310                 315                 320 


Leu Val Val Ala Cys Glu Ile Gln Val Arg Thr Leu Ala Ser Ala Gly 
                325                 330                 335     


Gly Pro Asp Asn Leu Val Leu Leu Asn Pro Glu Lys Tyr Lys Ala Lys 
            340                 345                 350         


Ser Arg Ser Pro Gly Ser Pro Val Gly Glu Gly Thr Gly Ser Pro Pro 
        355                 360                 365             


Lys Trp Gln Ile Gly Glu Gln Glu Phe Glu Ala Leu Met Arg Met Leu 
    370                 375                 380                 


Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Pro Tyr Arg Tyr Pro Ala Leu 
385                 390                 395                 400 


Arg Glu Lys Ser Lys Lys Tyr Ser Asp Val Glu Val Pro Ala Ser Val 
                405                 410                 415     


Thr Gly Tyr Ser Phe Ala Ser Asp Gly Asp Ser Gly Thr Cys Ser Pro 
            420                 425                 430         


Leu Arg His Ser Phe Gln Lys Gln Gln Arg Glu Lys Thr Arg Trp Leu 
        435                 440                 445             


Asn Ser Gly Arg Gly Asp Glu Ala Ser Glu Glu Gly Gln Asn Gly Ser 
    450                 455                 460                 


Ser Pro Lys Ser Lys Thr Lys Trp Thr Lys Glu Asp Gly His Arg Thr 
465                 470                 475                 480 


Ser Thr Ser Ala Val Pro Asn Leu Phe Val Pro Leu Asn Thr Asn Pro 
                485                 490                 495     


Lys Glu Val Gln Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Leu Gln 
            500                 505                 510         


Asp Ile Lys Thr Ala Gly Pro Gln Ser Gln Val Leu Cys Gly Val Val 
        515                 520                 525             


Met Asp Arg Ser Leu Val Gln Gly Glu Leu Val Thr Ala Ser Lys Ala 
    530                 535                 540                 


Ile Ile Glu Lys Glu Tyr Gln Pro His Val Ile Val Ser Thr Thr Gly 
545                 550                 555                 560 


Pro Asn Pro Phe Thr Thr Leu Thr Asp Arg Glu Leu Glu Glu Tyr Arg 
                565                 570                 575     


Arg Glu Val Glu Arg Lys Gln Lys Gly Ser Glu Glu Asn Leu Asp Glu 
            580                 585                 590         


Ala Arg Glu Gln Lys Glu Lys Ser Pro Pro Asp Gln Pro Ala Val Pro 
        595                 600                 605             


His Pro Pro Pro Ser Thr Pro Ile Lys Leu Glu Glu Asp Leu Val Pro 
    610                 615                 620                 


Glu Pro Thr Thr Gly Asp Asp Ser Asp Ala Ala Thr Phe Lys Pro Thr 
625                 630                 635                 640 


Leu Pro Asp Leu Ser Pro Asp Glu Pro Ser Glu Ala Leu Gly Phe Pro 
                645                 650                 655     


Met Leu Glu Lys Glu Glu Glu Ala His Arg Pro Pro Ser Pro Thr Glu 
            660                 665                 670         


Ala Pro Thr Glu Ala Ser Pro Glu Pro Ala Pro Asp Pro Ala Pro Val 
        675                 680                 685             


Ala Glu Glu Ala Ala Pro Ser Ala Val Glu Glu Gly Ala Ala Ala Asp 
    690                 695                 700                 


Pro Gly Ser Asp Gly Ser Pro Gly Lys Ser Pro Ser Lys Lys Lys Lys 
705                 710                 715                 720 


Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys Lys Ser Asp 
                725                 730                 735     


Ser 
    


<210>  182
<211>  886
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Arg Gly Phe Asn Leu Leu Leu Phe Trp Gly Cys Cys Val Met His 
1               5                   10                  15      


Ser Trp Glu Gly His Ile Arg Pro Thr Arg Lys Pro Asn Thr Lys Gly 
            20                  25                  30          


Asn Asn Cys Arg Asp Ser Thr Leu Cys Pro Ala Tyr Ala Thr Cys Thr 
        35                  40                  45              


Asn Thr Val Asp Ser Tyr Tyr Cys Ala Cys Lys Gln Gly Phe Leu Ser 
    50                  55                  60                  


Ser Asn Gly Gln Asn His Phe Lys Asp Pro Gly Val Arg Cys Lys Asp 
65                  70                  75                  80  


Ile Asp Glu Cys Ser Gln Ser Pro Gln Pro Cys Gly Pro Asn Ser Ser 
                85                  90                  95      


Cys Lys Asn Leu Ser Gly Arg Tyr Lys Cys Ser Cys Leu Asp Gly Phe 
            100                 105                 110         


Ser Ser Pro Thr Gly Asn Asp Trp Val Pro Gly Lys Pro Gly Asn Phe 
        115                 120                 125             


Ser Cys Thr Asp Ile Asn Glu Cys Leu Thr Ser Ser Val Cys Pro Glu 
    130                 135                 140                 


His Ser Asp Cys Val Asn Ser Met Gly Ser Tyr Ser Cys Ser Cys Gln 
145                 150                 155                 160 


Val Gly Phe Ile Ser Arg Asn Ser Thr Cys Glu Asp Val Asp Glu Cys 
                165                 170                 175     


Ala Asp Pro Arg Ala Cys Pro Glu His Ala Thr Cys Asn Asn Thr Val 
            180                 185                 190         


Gly Asn Tyr Ser Cys Phe Cys Asn Pro Gly Phe Glu Ser Ser Ser Gly 
        195                 200                 205             


His Leu Ser Phe Gln Gly Leu Lys Ala Ser Cys Glu Asp Ile Asp Glu 
    210                 215                 220                 


Cys Thr Glu Met Cys Pro Ile Asn Ser Thr Cys Thr Asn Thr Pro Gly 
225                 230                 235                 240 


Ser Tyr Phe Cys Thr Cys His Pro Gly Phe Ala Pro Ser Asn Gly Gln 
                245                 250                 255     


Leu Asn Phe Thr Asp Gln Gly Val Glu Cys Arg Asp Ile Asp Glu Cys 
            260                 265                 270         


Arg Gln Asp Pro Ser Thr Cys Gly Pro Asn Ser Ile Cys Thr Asn Ala 
        275                 280                 285             


Leu Gly Ser Tyr Ser Cys Gly Cys Ile Ala Gly Phe His Pro Asn Pro 
    290                 295                 300                 


Glu Gly Ser Gln Lys Asp Gly Asn Phe Ser Cys Gln Arg Val Leu Phe 
305                 310                 315                 320 


Lys Cys Lys Glu Asp Val Ile Pro Asp Asn Lys Gln Ile Gln Gln Cys 
                325                 330                 335     


Gln Glu Gly Thr Ala Val Lys Pro Ala Tyr Val Ser Phe Cys Ala Gln 
            340                 345                 350         


Ile Asn Asn Ile Phe Ser Val Leu Asp Lys Val Cys Glu Asn Lys Thr 
        355                 360                 365             


Thr Val Val Ser Leu Lys Asn Thr Thr Glu Ser Phe Val Pro Val Leu 
    370                 375                 380                 


Lys Gln Ile Ser Thr Trp Thr Lys Phe Thr Lys Glu Glu Thr Ser Ser 
385                 390                 395                 400 


Leu Ala Thr Val Phe Leu Glu Ser Val Glu Ser Met Thr Leu Ala Ser 
                405                 410                 415     


Phe Trp Lys Pro Ser Ala Asn Ile Thr Pro Ala Val Arg Thr Glu Tyr 
            420                 425                 430         


Leu Asp Ile Glu Ser Lys Val Ile Asn Lys Glu Cys Ser Glu Glu Asn 
        435                 440                 445             


Val Thr Leu Asp Leu Val Ala Lys Gly Asp Lys Met Lys Ile Gly Cys 
    450                 455                 460                 


Ser Thr Ile Glu Glu Ser Glu Ser Thr Glu Thr Thr Gly Val Ala Phe 
465                 470                 475                 480 


Val Ser Phe Val Gly Met Glu Ser Val Leu Asn Glu Arg Phe Phe Lys 
                485                 490                 495     


Asp His Gln Ala Pro Leu Thr Thr Ser Glu Ile Lys Leu Lys Met Asn 
            500                 505                 510         


Ser Arg Val Val Gly Gly Ile Met Thr Gly Glu Lys Lys Asp Gly Phe 
        515                 520                 525             


Ser Asp Pro Ile Ile Tyr Thr Leu Glu Asn Ile Gln Pro Lys Gln Lys 
    530                 535                 540                 


Phe Glu Arg Pro Ile Cys Val Ser Trp Ser Thr Asp Val Lys Gly Gly 
545                 550                 555                 560 


Arg Trp Thr Ser Phe Gly Cys Val Ile Leu Glu Ala Ser Glu Thr Tyr 
                565                 570                 575     


Thr Ile Cys Ser Cys Asn Gln Met Ala Asn Leu Ala Val Ile Met Ala 
            580                 585                 590         


Ser Gly Glu Leu Thr Met Asp Phe Ser Leu Tyr Ile Ile Ser His Val 
        595                 600                 605             


Gly Ile Ile Ile Ser Leu Val Cys Leu Val Leu Ala Ile Ala Thr Phe 
    610                 615                 620                 


Leu Leu Cys Arg Ser Ile Arg Asn His Asn Thr Tyr Leu His Leu His 
625                 630                 635                 640 


Leu Cys Val Cys Leu Leu Leu Ala Lys Thr Leu Phe Leu Ala Gly Ile 
                645                 650                 655     


His Lys Thr Asp Asn Lys Met Gly Cys Ala Ile Ile Ala Gly Phe Leu 
            660                 665                 670         


His Tyr Leu Phe Leu Ala Cys Phe Phe Trp Met Leu Val Glu Ala Val 
        675                 680                 685             


Ile Leu Phe Leu Met Val Arg Asn Leu Lys Val Val Asn Tyr Phe Ser 
    690                 695                 700                 


Ser Arg Asn Ile Lys Met Leu His Ile Cys Ala Phe Gly Tyr Gly Leu 
705                 710                 715                 720 


Pro Met Leu Val Val Val Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr 
                725                 730                 735     


Gly Met His Asn Arg Cys Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp 
            740                 745                 750         


Ser Phe Leu Gly Pro Val Cys Thr Val Ile Val Ile Asn Ser Leu Leu 
        755                 760                 765             


Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn 
    770                 775                 780                 


Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala 
785                 790                 795                 800 


Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe 
                805                 810                 815     


Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile Ile 
            820                 825                 830         


Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn 
        835                 840                 845             


Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr Lys 
    850                 855                 860                 


Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met Pro 
865                 870                 875                 880 


Ser Ala Ser Lys Thr Gly 
                885     


<210>  183
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu 
1               5                   10                  15      


Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu 
            20                  25                  30          


Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu 
        35                  40                  45              


Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp 
    50                  55                  60                  


Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro 
65                  70                  75                  80  


Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly 
                85                  90                  95      


Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly 
            100                 105                 110         


Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala 
        115                 120                 125             


Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser 
    130                 135                 140                 


Glu Leu Pro 
145         


<210>  184
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Gly Gln Leu Cys Cys Phe Pro Phe Ser Arg Asp Glu Gly Lys Ile 
1               5                   10                  15      


Ser Glu Lys Asn Gly Gly Glu Pro Asp Asp Ala Glu Leu Val Arg Leu 
            20                  25                  30          


Ser Lys Arg Leu Val Glu Asn Ala Val Leu Lys Ala Val Gln Gln Tyr 
        35                  40                  45              


Leu Glu Glu Thr Gln Asn Lys Asn Lys Pro Gly Glu Gly Ser Ser Val 
    50                  55                  60                  


Lys Thr Glu Ala Ala Asp Gln Asn Gly Asn Asp Asn Glu Asn Asn Arg 
65                  70                  75                  80  


Lys 
    


<210>  185
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


<210>  186
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Asn Pro Phe Trp Ser Met Ser Thr Ser Ser Val Arg Lys Arg Ser 
1               5                   10                  15      


Glu Gly Glu Glu Lys Thr Leu Thr Gly Asp Val Lys Thr Ser Pro Pro 
            20                  25                  30          


Arg Thr Ala Pro Lys Lys Gln Leu Pro Ser Ile Pro Lys Asn Ala Leu 
        35                  40                  45              


Pro Ile Thr Lys Pro Thr Ser Pro Ala Pro Ala Ala Gln Ser Thr Asn 
    50                  55                  60                  


Gly Thr His Ala Ser Tyr Gly Pro Phe Tyr Leu Glu Tyr Ser Leu Leu 
65                  70                  75                  80  


Ala Glu Phe Thr Leu Val Val Lys Gln Lys Leu Pro Gly Val Tyr Val 
                85                  90                  95      


Gln Pro Ser Tyr Arg Ser Ala Leu Met Trp Phe Gly Val Ile Phe Ile 
            100                 105                 110         


Arg His Gly Leu Tyr Gln Asp Gly Val Phe Lys Phe Thr Val Tyr Ile 
        115                 120                 125             


Pro Asp Asn Tyr Pro Asp Gly Asp Cys Pro Arg Leu Val Phe Asp Ile 
    130                 135                 140                 


Pro Val Phe His Pro Leu Val Asp Pro Thr Ser Gly Glu Leu Asp Val 
145                 150                 155                 160 


Lys Arg Ala Phe Ala Lys Trp Arg Arg Asn His Asn His Ile Trp Gln 
                165                 170                 175     


Val Leu Met Tyr Ala Arg Arg Val Phe Tyr Lys Ile Asp Thr Ala Ser 
            180                 185                 190         


Pro Leu Asn Pro Glu Ala Ala Val Leu Tyr Glu Lys Asp Ile Gln Leu 
        195                 200                 205             


Phe Lys Ser Lys Val Val Asp Ser Val Lys Val Cys Thr Ala Arg Leu 
    210                 215                 220                 


Phe Asp Gln Pro Lys Ile Glu Asp Pro Tyr Ala Ile Ser Phe Ser Pro 
225                 230                 235                 240 


Trp Asn Pro Ser Val His Asp Glu Ala Arg Glu Lys Met Leu Thr Gln 
                245                 250                 255     


Lys Lys Pro Glu Glu Gln His Asn Lys Ser Val His Val Ala Gly Leu 
            260                 265                 270         


Ser Trp Val Lys Pro Gly Ser Val Gln Pro Phe Ser Lys Glu Glu Lys 
        275                 280                 285             


Thr Val Ala Thr 
    290         


<210>  187
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  188
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Glu Ala Ala His Phe Phe Glu Gly Thr Glu Lys Leu Leu Glu Val 
1               5                   10                  15      


Trp Phe Ser Arg Gln Gln Pro Asp Ala Asn Gln Gly Ser Gly Asp Leu 
            20                  25                  30          


Arg Thr Ile Pro Arg Ser Glu Trp Asp Ile Leu Leu Lys Asp Val Gln 
        35                  40                  45              


Cys Ser Ile Ile Ser Val Thr Lys Thr Asp Lys Gln Glu Ala Tyr Val 
    50                  55                  60                  


Leu Ser Glu Ser Ser Met Phe Val Ser Lys Arg Arg Phe Ile Leu Lys 
65                  70                  75                  80  


Thr Cys Gly Thr Thr Leu Leu Leu Lys Ala Leu Val Pro Leu Leu Lys 
                85                  90                  95      


Leu Ala Arg Asp Tyr Ser Gly Phe Asp Ser Ile Gln Ser Phe Phe Tyr 
            100                 105                 110         


Ser Arg Lys Asn Phe Met Lys Pro Ser His Gln Gly Tyr Pro His Arg 
        115                 120                 125             


Asn Phe Gln Glu Glu Ile Glu Phe Leu Asn Ala Ile Phe Pro Asn Gly 
    130                 135                 140                 


Ala Ala Tyr Cys Met Gly Arg Met Asn Ser Asp Cys Trp Tyr Leu Tyr 
145                 150                 155                 160 


Thr Leu Asp Phe Pro Glu Ser Arg Val Ile Ser Gln Pro Asp Gln Thr 
                165                 170                 175     


Leu Glu Ile Leu Met Ser Glu Leu Asp Pro Ala Val Met Asp Gln Phe 
            180                 185                 190         


Tyr Met Lys Asp Gly Val Thr Ala Lys Asp Val Thr Arg Glu Ser Gly 
        195                 200                 205             


Ile Arg Asp Leu Ile Pro Gly Ser Val Ile Asp Ala Thr Met Phe Asn 
    210                 215                 220                 


Pro Cys Gly Tyr Ser Met Asn Gly Met Lys Ser Asp Gly Thr Tyr Trp 
225                 230                 235                 240 


Thr Ile His Ile Thr Pro Glu Pro Glu Phe Ser Tyr Val Ser Phe Glu 
                245                 250                 255     


Thr Asn Leu Ser Gln Thr Ser Tyr Asp Asp Leu Ile Arg Lys Val Val 
            260                 265                 270         


Glu Val Phe Lys Pro Gly Lys Phe Val Thr Thr Leu Phe Val Asn Gln 
        275                 280                 285             


Ser Ser Lys Cys Arg Thr Val Leu Ala Ser Pro Gln Lys Ile Glu Gly 
    290                 295                 300                 


Phe Lys Arg Leu Asp Cys Gln Ser Ala Met Phe Asn Asp Tyr Asn Phe 
305                 310                 315                 320 


Val Phe Thr Ser Phe Ala Lys Lys Gln Gln Gln Gln Gln Ser 
                325                 330                 


<210>  189
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Asp Ala Leu Glu Gly Glu Ser Phe Ala Leu Ser Phe Ser Ser Ala 
1               5                   10                  15      


Ser Asp Ala Glu Phe Asp Ala Val Val Gly Tyr Leu Glu Asp Ile Ile 
            20                  25                  30          


Met Asp Asp Glu Phe Gln Leu Leu Gln Arg Asn Phe Met Asp Lys Tyr 
        35                  40                  45              


Tyr Leu Glu Phe Glu Asp Thr Glu Glu Asn Lys Leu Ile Tyr Thr Pro 
    50                  55                  60                  


Ile Phe Asn Glu Tyr Ile Ser Leu Val Glu Lys Tyr Ile Glu Glu Gln 
65                  70                  75                  80  


Leu Leu Gln Arg Ile Pro Glu Phe Asn Met Ala Ala Phe Thr Thr Thr 
                85                  90                  95      


Leu Gln His His Lys Asp Glu Val Ala Gly Asp Ile Phe Asp Met Leu 
            100                 105                 110         


Leu Thr Phe Thr Asp Phe Leu Ala Phe Lys Glu Met Phe Leu Asp Tyr 
        115                 120                 125             


Arg Ala Glu Lys Glu Gly Arg Gly Leu Asp Leu Ser Ser Gly Leu Val 
    130                 135                 140                 


Val Thr Ser Leu Cys Lys Ser Ser Ser Leu Pro Ala Ser Gln Asn Asn 
145                 150                 155                 160 


Leu Arg His 
            


<210>  190
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Gln Phe Asp Thr Glu Tyr Gln Arg Leu Glu Ala Ser Tyr Ser 
1               5                   10                  15      


Asp Ser Pro Pro Gly Glu Glu Asp Leu Leu Val His Val Ala Glu Gly 
            20                  25                  30          


Ser Lys Ser Pro Trp His His Ile Glu Asn Leu Asp Leu Phe Phe Ser 
        35                  40                  45              


Arg Val Tyr Asn Leu His Gln Lys Asn Gly Phe Thr Cys Met Leu Ile 
    50                  55                  60                  


Gly Glu Ile Phe Glu Leu Met Gln Phe Leu Phe Val Val Ala Phe Thr 
65                  70                  75                  80  


Thr Phe Leu Val Ser Cys Val Asp Tyr Asp Ile Leu Phe Ala Asn Lys 
                85                  90                  95      


Met Val Asn His Ser Leu His Pro Thr Glu Pro Val Lys Val Thr Leu 
            100                 105                 110         


Pro Asp Ala Phe Leu Pro Ala Gln Val Cys Ser Ala Arg Ile Gln Glu 
        115                 120                 125             


Asn Gly Ser Leu Ile Thr Ile Leu Val Ile Ala Gly Val Phe Trp Ile 
    130                 135                 140                 


His Arg Leu Ile Lys Phe Ile Tyr Asn Ile Cys Cys Tyr Trp Glu Ile 
145                 150                 155                 160 


His Ser Phe Tyr Leu His Ala Leu Arg Ile Pro Met Ser Ala Leu Pro 
                165                 170                 175     


Tyr Cys Thr Trp Gln Glu Val Gln Ala Arg Ile Val Gln Thr Gln Lys 
            180                 185                 190         


Glu His Gln Ile Cys Ile His Lys Arg Glu Leu Thr Glu Leu Asp Ile 
        195                 200                 205             


Tyr His Arg Ile Leu Arg Phe Gln Asn Tyr Met Val Ala Leu Val Asn 
    210                 215                 220                 


Lys Ser Leu Leu Pro Leu Arg Phe Arg Leu Pro Gly Leu Gly Glu Ala 
225                 230                 235                 240 


Val Phe Phe Thr Arg Gly Leu Lys Tyr Asn Phe Glu Leu Ile Leu Phe 
                245                 250                 255     


Trp Gly Pro Gly Ser Leu Phe Leu Asn Glu Trp Ser Leu Lys Ala Glu 
            260                 265                 270         


Tyr Lys Arg Gly Gly Gln Arg Leu Glu Leu Ala Gln Arg Leu Ser Asn 
        275                 280                 285             


Arg Ile Leu Trp Ile Gly Ile Ala Asn Phe Leu Leu Cys Pro Leu Ile 
    290                 295                 300                 


Leu Ile Trp Gln Ile Leu Tyr Ala Phe Phe Ser Tyr Ala Glu Val Leu 
305                 310                 315                 320 


Lys Arg Glu Pro Gly Ala Leu Gly Ala Arg Cys Trp Ser Leu Tyr Gly 
                325                 330                 335     


Arg Cys Tyr Leu Arg His Phe Asn Glu Leu Glu His Glu Leu Gln Ser 
            340                 345                 350         


Arg Leu Asn Arg Gly Tyr Lys Pro Ala Ser Lys Tyr Met Asn Cys Phe 
        355                 360                 365             


Leu Ser Pro Leu Leu Thr Leu Leu Ala Lys Asn Gly Ala Phe Phe Ala 
    370                 375                 380                 


Gly Ser Ile Leu Ala Val Leu Ile Ala Leu Thr Ile Tyr Asp Glu Asp 
385                 390                 395                 400 


Val Leu Ala Val Glu His Val Leu Thr Thr Val Thr Leu Leu Gly Val 
                405                 410                 415     


Thr Val Thr Val Cys Arg Ser Phe Ile Pro Asp Gln His Met Val Phe 
            420                 425                 430         


Cys Pro Glu Gln Leu Leu Arg Val Ile Leu Ala His Ile His Tyr Met 
        435                 440                 445             


Pro Asp His Trp Gln Gly Asn Ala His Arg Ser Gln Thr Arg Asp Glu 
    450                 455                 460                 


Phe Ala Gln Leu Phe Gln Tyr Lys Ala Val Phe Ile Leu Glu Glu Leu 
465                 470                 475                 480 


Leu Ser Pro Ile Val Thr Pro Leu Ile Leu Ile Phe Cys Leu Arg Pro 
                485                 490                 495     


Arg Ala Leu Glu Ile Ile Asp Phe Phe Arg Asn Phe Thr Val Glu Val 
            500                 505                 510         


Val Gly Val Gly Asp Thr Cys Ser Phe Ala Gln Met Asp Val Arg Gln 
        515                 520                 525             


His Gly His Pro Gln Trp Leu Ser Ala Gly Gln Thr Glu Ala Ser Val 
    530                 535                 540                 


Tyr Gln Gln Ala Glu Asp Gly Lys Thr Glu Leu Ser Leu Met His Phe 
545                 550                 555                 560 


Ala Ile Thr Asn Pro Gly Trp Gln Pro Pro Arg Glu Ser Thr Ala Phe 
                565                 570                 575     


Leu Gly Phe Leu Lys Glu Gln Val Gln Arg Asp Gly Ala Ala Ala Ser 
            580                 585                 590         


Leu Ala Gln Gly Gly Leu Leu Pro Glu Asn Ala Leu Phe Thr Ser Ile 
        595                 600                 605             


Gln Ser Leu Gln Ser Glu Ser Glu Pro Leu Ser Leu Ile Ala Asn Val 
    610                 615                 620                 


Val Ala Gly Ser Ser Cys Arg Gly Pro Pro Leu Pro Arg Asp Leu Gln 
625                 630                 635                 640 


Gly Ser Arg His Arg Ala Glu Val Ala Ser Ala Leu Arg Ser Phe Ser 
                645                 650                 655     


Pro Leu Gln Pro Gly Gln Ala Pro Thr Gly Arg Ala His Ser Thr Met 
            660                 665                 670         


Thr Gly Ser Gly Val Asp Ala Arg Thr Ala Ser Ser Gly Ser Ser Val 
        675                 680                 685             


Trp Glu Gly Gln Leu Gln Ser Leu Val Leu Ser Glu Tyr Ala Ser Thr 
    690                 695                 700                 


Glu Met Ser Leu His Ala Leu Tyr Met His Gln Leu His Lys Gln Gln 
705                 710                 715                 720 


Ala Gln Ala Glu Pro Glu Arg His Val Trp His Arg Arg Glu Ser Asp 
                725                 730                 735     


Glu Ser Gly Glu Ser Ala Pro Asp Glu Gly Gly Glu Gly Ala Arg Ala 
            740                 745                 750         


Pro Gln Ser Ile Pro Arg Ser Ala Ser Tyr Pro Cys Ala Ala Pro Arg 
        755                 760                 765             


Pro Gly Ala Pro Glu Thr Thr Ala Leu His Gly Gly Phe Gln Arg Arg 
    770                 775                 780                 


Tyr Gly Gly Ile Thr Asp Pro Gly Thr Val Pro Arg Val Pro Ser His 
785                 790                 795                 800 


Phe Ser Arg Leu Pro Leu Gly Gly Trp Ala Glu Asp Gly Gln Ser Ala 
                805                 810                 815     


Ser Arg His Pro Glu Pro Val Pro Glu Glu Gly Ser Glu Asp Glu Leu 
            820                 825                 830         


Pro Pro Gln Val His Lys Val 
        835                 


<210>  191
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Asp Arg Glu Glu Arg Lys Thr Ile Asn Gln Gly Gln Glu Asp Glu 
1               5                   10                  15      


Met Glu Ile Tyr Gly Tyr Asn Leu Ser Arg Trp Lys Leu Ala Ile Val 
            20                  25                  30          


Ser Leu Gly Val Ile Cys Ser Gly Gly Phe Leu Leu Leu Leu Leu Tyr 
        35                  40                  45              


Trp Met Pro Glu Trp Arg Val Lys Ala Thr Cys Val Arg Ala Ala Ile 
    50                  55                  60                  


Lys Asp Cys Glu Val Val Leu Leu Arg Thr Thr Asp Glu Phe Lys Met 
65                  70                  75                  80  


Trp Phe Cys Ala Lys Ile Arg Val Leu Ser Leu Glu Thr Tyr Pro Val 
                85                  90                  95      


Ser Ser Pro Lys Ser Met Ser Asn Lys Leu Ser Asn Gly His Ala Val 
            100                 105                 110         


Cys Leu Ile Glu Asn Pro Thr Glu Glu Asn Arg His Arg Ile Ser Lys 
        115                 120                 125             


Tyr Ser Gln Thr Glu Ser Gln Gln Ile Arg Tyr Phe Thr His His Ser 
    130                 135                 140                 


Val Lys Tyr Phe Trp Asn Asp Thr Ile His Asn Phe Asp Phe Leu Lys 
145                 150                 155                 160 


Gly Leu Asp Glu Gly Val Ser Cys Thr Ser Ile Tyr Glu Lys His Ser 
                165                 170                 175     


Ala Gly Leu Thr Lys Gly Met His Ala Tyr Arg Lys Leu Leu Tyr Gly 
            180                 185                 190         


Val Asn Glu Ile Ala Val Lys Val Pro Ser Val Phe Lys Leu Leu Ile 
        195                 200                 205             


Lys Glu Val Leu Asn Pro Phe Tyr Ile Phe Gln Leu Phe Ser Val Ile 
    210                 215                 220                 


Leu Trp Ser Thr Asp Glu Tyr Tyr Tyr Tyr Ala Leu Ala Ile Val Val 
225                 230                 235                 240 


Met Ser Ile Val Ser Ile Val Ser Ser Leu Tyr Ser Ile Arg Lys Gln 
                245                 250                 255     


Tyr Val Met Leu His Asp Met Val Ala Thr His Ser Thr Val Arg Val 
            260                 265                 270         


Ser Val Cys Arg Val Asn Glu Glu Ile Glu Glu Ile Phe Ser Thr Asp 
        275                 280                 285             


Leu Val Pro Gly Asp Val Met Val Ile Pro Leu Asn Gly Thr Ile Met 
    290                 295                 300                 


Pro Cys Asp Ala Val Leu Ile Asn Gly Thr Cys Ile Val Asn Glu Ser 
305                 310                 315                 320 


Met Leu Thr Gly Glu Ser Val Pro Val Thr Lys Thr Asn Leu Pro Asn 
                325                 330                 335     


Pro Ser Val Asp Val Lys Gly Ile Gly Asp Glu Leu Tyr Asn Pro Glu 
            340                 345                 350         


Thr His Lys Arg His Thr Leu Phe Cys Gly Thr Thr Val Ile Gln Thr 
        355                 360                 365             


Arg Phe Tyr Thr Gly Glu Leu Val Lys Ala Ile Val Val Arg Thr Gly 
    370                 375                 380                 


Phe Ser Thr Ser Lys Gly Gln Leu Val Arg Ser Ile Leu Tyr Pro Lys 
385                 390                 395                 400 


Pro Thr Asp Phe Lys Leu Tyr Arg Asp Ala Tyr Leu Phe Leu Leu Cys 
                405                 410                 415     


Leu Val Ala Val Ala Gly Ile Gly Phe Ile Tyr Thr Ile Ile Asn Ser 
            420                 425                 430         


Ile Leu Asn Glu Val Gln Val Gly Val Ile Ile Ile Glu Ser Leu Asp 
        435                 440                 445             


Ile Ile Thr Ile Thr Val Pro Pro Ala Leu Pro Ala Ala Met Thr Ala 
    450                 455                 460                 


Gly Ile Val Tyr Ala Gln Arg Arg Leu Lys Lys Ile Gly Ile Phe Cys 
465                 470                 475                 480 


Ile Ser Pro Gln Arg Ile Asn Ile Cys Gly Gln Leu Asn Leu Val Cys 
                485                 490                 495     


Phe Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Leu Trp Gly 
            500                 505                 510         


Ile Gln Arg Val Glu Asn Ala Arg Phe Leu Ser Pro Glu Glu Asn Val 
        515                 520                 525             


Cys Asn Glu Met Leu Val Lys Ser Gln Phe Val Ala Cys Met Ala Thr 
    530                 535                 540                 


Cys His Ser Leu Thr Lys Ile Glu Gly Val Leu Ser Gly Asp Pro Leu 
545                 550                 555                 560 


Asp Leu Lys Met Phe Glu Ala Ile Gly Trp Ile Leu Glu Glu Ala Thr 
                565                 570                 575     


Glu Glu Glu Thr Ala Leu His Asn Arg Ile Met Pro Thr Val Val Arg 
            580                 585                 590         


Pro Pro Lys Gln Leu Leu Pro Glu Ser Thr Pro Ala Gly Asn Gln Glu 
        595                 600                 605             


Met Glu Leu Phe Glu Leu Pro Ala Thr Tyr Glu Ile Gly Ile Val Arg 
    610                 615                 620                 


Gln Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val Ala Arg 
625                 630                 635                 640 


Val Leu Gly Asp Arg Lys Met Asp Ala Tyr Met Lys Gly Ala Pro Glu 
                645                 650                 655     


Ala Ile Ala Gly Leu Cys Lys Pro Glu Thr Val Pro Val Asp Phe Gln 
            660                 665                 670         


Asn Val Leu Glu Asp Phe Thr Lys Gln Gly Phe Arg Val Ile Ala Leu 
        675                 680                 685             


Ala His Arg Lys Leu Glu Ser Lys Leu Thr Trp His Lys Val Gln Asn 
    690                 695                 700                 


Ile Ser Arg Asp Ala Ile Glu Asn Asn Met Asp Phe Met Gly Leu Ile 
705                 710                 715                 720 


Ile Met Gln Asn Lys Leu Lys Gln Glu Thr Pro Ala Val Leu Glu Asp 
                725                 730                 735     


Leu His Lys Ala Asn Ile Arg Thr Val Met Val Thr Gly Asp Ser Met 
            740                 745                 750         


Leu Thr Ala Val Ser Val Ala Arg Asp Cys Gly Met Ile Leu Pro Gln 
        755                 760                 765             


Asp Lys Val Ile Ile Ala Glu Ala Leu Pro Pro Lys Asp Gly Lys Val 
    770                 775                 780                 


Ala Lys Ile Asn Trp His Tyr Ala Asp Ser Leu Thr Gln Cys Ser His 
785                 790                 795                 800 


Pro Ser Ala Ile Asp Pro Glu Ala Ile Pro Val Lys Leu Val His Asp 
                805                 810                 815     


Ser Leu Glu Asp Leu Gln Met Thr Arg Tyr His Phe Ala Met Asn Gly 
            820                 825                 830         


Lys Ser Phe Ser Val Ile Leu Glu His Phe Gln Asp Leu Val Pro Lys 
        835                 840                 845             


Leu Met Leu His Gly Thr Val Phe Ala Arg Met Ala Pro Asp Gln Lys 
    850                 855                 860                 


Thr Gln Leu Ile Glu Ala Leu Gln Asn Val Asp Tyr Phe Val Gly Met 
865                 870                 875                 880 


Cys Gly Asp Gly Ala Asn Asp Cys Gly Ala Leu Lys Arg Ala His Gly 
                885                 890                 895     


Gly Ile Ser Leu Ser Glu Leu Glu Ala Ser Val Ala Ser Pro Phe Thr 
            900                 905                 910         


Ser Lys Thr Pro Ser Ile Ser Cys Val Pro Asn Leu Ile Arg Glu Gly 
        915                 920                 925             


Arg Ala Ala Leu Ile Thr Ser Phe Cys Val Phe Lys Phe Met Ala Leu 
    930                 935                 940                 


Tyr Ser Ile Ile Gln Tyr Phe Ser Val Thr Leu Leu Tyr Ser Ile Leu 
945                 950                 955                 960 


Ser Asn Leu Gly Asp Phe Gln Phe Leu Phe Ile Asp Leu Ala Ile Ile 
                965                 970                 975     


Leu Val Val Val Phe Thr Met Ser Leu Asn Pro Ala Trp Lys Glu Leu 
            980                 985                 990         


Val Ala Gln Arg Pro Pro Ser Gly  Leu Ile Ser Gly Ala  Leu Leu Phe 
        995                 1000                 1005             


Ser Val  Leu Ser Gln Ile Ile  Ile Cys Ile Gly Phe  Gln Ser Leu 
    1010                 1015                 1020             


Gly Phe  Phe Trp Val Lys Gln  Gln Pro Trp Tyr Glu  Val Trp His 
    1025                 1030                 1035             


Pro Lys  Ser Asp Ala Cys Asn  Thr Thr Gly Ser Gly  Phe Trp Asn 
    1040                 1045                 1050             


Ser Ser  His Val Asp Asn Glu  Thr Glu Leu Asp Glu  His Asn Ile 
    1055                 1060                 1065             


Gln Asn  Tyr Glu Asn Thr Thr  Val Phe Phe Ile Ser  Ser Phe Gln 
    1070                 1075                 1080             


Tyr Leu  Ile Val Ala Ile Ala  Phe Ser Lys Gly Lys  Pro Phe Arg 
    1085                 1090                 1095             


Gln Pro  Cys Tyr Lys Asn Tyr  Phe Phe Val Phe Ser  Val Ile Phe 
    1100                 1105                 1110             


Leu Tyr  Ile Phe Ile Leu Phe  Ile Met Leu Tyr Pro  Val Ala Ser 
    1115                 1120                 1125             


Val Asp  Gln Val Leu Gln Ile  Val Cys Val Pro Tyr  Gln Trp Arg 
    1130                 1135                 1140             


Val Thr  Met Leu Ile Ile Val  Leu Val Asn Ala Phe  Val Ser Ile 
    1145                 1150                 1155             


Thr Val  Glu Glu Ser Val Asp  Arg Trp Gly Lys Cys  Cys Leu Pro 
    1160                 1165                 1170             


Trp Ala  Leu Gly Cys Arg Lys  Lys Thr Pro Lys Ala  Lys Tyr Met 
    1175                 1180                 1185             


Tyr Leu  Ala Gln Glu Leu Leu  Val Asp Pro Glu Trp  Pro Pro Lys 
    1190                 1195                 1200             


Pro Gln  Thr Thr Thr Glu Ala  Lys Ala Leu Val Lys  Glu Asn Gly 
    1205                 1210                 1215             


Ser Cys  Gln Ile Ile Thr Ile  Thr 
    1220                 1225     


<210>  192
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Gly Glu Leu Phe Arg Ser Glu Glu Met Thr Leu Ala Gln Leu Phe 
1               5                   10                  15      


Leu Gln Ser Glu Ala Ala Tyr Cys Cys Val Ser Glu Leu Gly Glu Leu 
            20                  25                  30          


Gly Lys Val Gln Phe Arg Asp Leu Asn Pro Asp Val Asn Val Phe Gln 
        35                  40                  45              


Arg Lys Phe Val Asn Glu Val Arg Arg Cys Glu Glu Met Asp Arg Lys 
    50                  55                  60                  


Leu Arg Phe Val Glu Lys Glu Ile Arg Lys Ala Asn Ile Pro Ile Met 
65                  70                  75                  80  


Asp Thr Gly Glu Asn Pro Glu Val Pro Phe Pro Arg Asp Met Ile Asp 
                85                  90                  95      


Leu Glu Ala Asn Phe Glu Lys Ile Glu Asn Glu Leu Lys Glu Ile Asn 
            100                 105                 110         


Thr Asn Gln Glu Ala Leu Lys Arg Asn Phe Leu Glu Leu Thr Glu Leu 
        115                 120                 125             


Lys Phe Ile Leu Arg Lys Thr Gln Gln Phe Phe Asp Glu Met Ala Asp 
    130                 135                 140                 


Pro Asp Leu Leu Glu Glu Ser Ser Ser Leu Leu Glu Pro Ser Glu Met 
145                 150                 155                 160 


Gly Arg Gly Thr Pro Leu Arg Leu Gly Phe Val Ala Gly Val Ile Asn 
                165                 170                 175     


Arg Glu Arg Ile Pro Thr Phe Glu Arg Met Leu Trp Arg Val Cys Arg 
            180                 185                 190         


Gly Asn Val Phe Leu Arg Gln Ala Glu Ile Glu Asn Pro Leu Glu Asp 
        195                 200                 205             


Pro Val Thr Gly Asp Tyr Val His Lys Ser Val Phe Ile Ile Phe Phe 
    210                 215                 220                 


Gln Gly Asp Gln Leu Lys Asn Arg Val Lys Lys Ile Cys Glu Gly Phe 
225                 230                 235                 240 


Arg Ala Ser Leu Tyr Pro Cys Pro Glu Thr Pro Gln Glu Arg Lys Glu 
                245                 250                 255     


Met Ala Ser Gly Val Asn Thr Arg Ile Asp Asp Leu Gln Met Val Leu 
            260                 265                 270         


Asn Gln Thr Glu Asp His Arg Gln Arg Val Leu Gln Ala Ala Ala Lys 
        275                 280                 285             


Asn Ile Arg Val Trp Phe Ile Lys Val Arg Lys Met Lys Ala Ile Tyr 
    290                 295                 300                 


His Thr Leu Asn Leu Cys Asn Ile Asp Val Thr Gln Lys Cys Leu Ile 
305                 310                 315                 320 


Ala Glu Val Trp Cys Pro Val Thr Asp Leu Asp Ser Ile Gln Phe Ala 
                325                 330                 335     


Leu Arg Arg Gly Thr Glu His Ser Gly Ser Thr Val Pro Ser Ile Leu 
            340                 345                 350         


Asn Arg Met Gln Thr Asn Gln Thr Pro Pro Thr Tyr Asn Lys Thr Asn 
        355                 360                 365             


Lys Phe Thr Tyr Gly Phe Gln Asn Ile Val Asp Ala Tyr Gly Ile Gly 
    370                 375                 380                 


Thr Tyr Arg Glu Ile Asn Pro Ala Pro Tyr Thr Ile Ile Thr Phe Pro 
385                 390                 395                 400 


Phe Leu Phe Ala Val Met Phe Gly Asp Phe Gly His Gly Ile Leu Met 
                405                 410                 415     


Thr Leu Phe Ala Val Trp Met Val Leu Arg Glu Ser Arg Ile Leu Ser 
            420                 425                 430         


Gln Lys Asn Glu Asn Glu Met Phe Ser Thr Val Phe Ser Gly Arg Tyr 
        435                 440                 445             


Ile Ile Leu Leu Met Gly Val Phe Ser Met Tyr Thr Gly Leu Ile Tyr 
    450                 455                 460                 


Asn Asp Cys Phe Ser Lys Ser Leu Asn Ile Phe Gly Ser Ser Trp Ser 
465                 470                 475                 480 


Val Arg Pro Met Phe Thr Tyr Asn Trp Thr Glu Glu Thr Leu Arg Gly 
                485                 490                 495     


Asn Pro Val Leu Gln Leu Asn Pro Ala Leu Pro Gly Val Phe Gly Gly 
            500                 505                 510         


Pro Tyr Pro Phe Gly Ile Asp Pro Ile Trp Asn Ile Ala Thr Asn Lys 
        515                 520                 525             


Leu Thr Phe Leu Asn Ser Phe Lys Met Lys Met Ser Val Ile Leu Gly 
    530                 535                 540                 


Ile Ile His Met Leu Phe Gly Val Ser Leu Ser Leu Phe Asn His Ile 
545                 550                 555                 560 


Tyr Phe Lys Lys Pro Leu Asn Ile Tyr Phe Gly Phe Ile Pro Glu Ile 
                565                 570                 575     


Ile Phe Met Thr Ser Leu Phe Gly Tyr Leu Val Ile Leu Ile Phe Tyr 
            580                 585                 590         


Lys Trp Thr Ala Tyr Asp Ala His Thr Ser Glu Asn Ala Pro Ser Leu 
        595                 600                 605             


Leu Ile His Phe Ile Asn Met Phe Leu Phe Ser Tyr Pro Glu Ser Gly 
    610                 615                 620                 


Tyr Ser Met Leu Tyr Ser Gly Gln Lys Gly Ile Gln Cys Phe Leu Val 
625                 630                 635                 640 


Val Val Ala Leu Leu Cys Val Pro Trp Met Leu Leu Phe Lys Pro Leu 
                645                 650                 655     


Val Leu Arg Arg Gln Tyr Leu Arg Arg Lys His Leu Gly Thr Leu Asn 
            660                 665                 670         


Phe Gly Gly Ile Arg Val Gly Asn Gly Pro Thr Glu Glu Asp Ala Glu 
        675                 680                 685             


Ile Ile Gln His Asp Gln Leu Ser Thr His Ser Glu Asp Ala Asp Glu 
    690                 695                 700                 


Phe Asp Phe Gly Asp Thr Met Val His Gln Ala Ile His Thr Ile Glu 
705                 710                 715                 720 


Tyr Cys Leu Gly Cys Ile Ser Asn Thr Ala Ser Tyr Leu Arg Leu Trp 
                725                 730                 735     


Ala Leu Ser Leu Ala His Ala Gln Leu Ser Glu Val Leu Trp Thr Met 
            740                 745                 750         


Val Ile His Ile Gly Leu Ser Val Lys Ser Leu Ala Gly Gly Leu Val 
        755                 760                 765             


Leu Phe Phe Phe Phe Thr Ala Phe Ala Thr Leu Thr Val Ala Ile Leu 
    770                 775                 780                 


Leu Ile Met Glu Gly Leu Ser Ala Phe Leu His Ala Leu Arg Leu His 
785                 790                 795                 800 


Trp Val Glu Phe Gln Asn Lys Phe Tyr Ser Gly Thr Gly Phe Lys Phe 
                805                 810                 815     


Leu Pro Phe Ser Phe Glu His Ile Arg Glu Gly Lys Phe Glu Glu 
            820                 825                 830     


<210>  193
<211>  1192
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Phe Cys Ser Glu Lys Lys Leu Arg Glu Val Glu Arg Ile Val Lys 
1               5                   10                  15      


Ala Asn Asp Arg Glu Tyr Asn Glu Lys Phe Gln Tyr Ala Asp Asn Arg 
            20                  25                  30          


Ile His Thr Ser Lys Tyr Asn Ile Leu Thr Phe Leu Pro Ile Asn Leu 
        35                  40                  45              


Phe Glu Gln Phe Gln Arg Val Ala Asn Ala Tyr Phe Leu Cys Leu Leu 
    50                  55                  60                  


Ile Leu Gln Leu Ile Pro Glu Ile Ser Ser Leu Thr Trp Phe Thr Thr 
65                  70                  75                  80  


Ile Val Pro Leu Val Leu Val Ile Thr Met Thr Ala Val Lys Asp Ala 
                85                  90                  95      


Thr Asp Asp Tyr Phe Arg His Lys Ser Asp Asn Gln Val Asn Asn Arg 
            100                 105                 110         


Gln Ser Glu Val Leu Ile Asn Ser Lys Leu Gln Asn Glu Lys Trp Met 
        115                 120                 125             


Asn Val Lys Val Gly Asp Ile Ile Lys Leu Glu Asn Asn Gln Phe Val 
    130                 135                 140                 


Ala Ala Asp Leu Leu Leu Leu Ser Ser Ser Glu Pro His Gly Leu Cys 
145                 150                 155                 160 


Tyr Val Glu Thr Ala Glu Leu Asp Gly Glu Thr Asn Leu Lys Val Arg 
                165                 170                 175     


His Ala Leu Ser Val Thr Ser Glu Leu Gly Ala Asp Ile Ser Arg Leu 
            180                 185                 190         


Ala Gly Phe Asp Gly Ile Val Val Cys Glu Val Pro Asn Asn Lys Leu 
        195                 200                 205             


Asp Lys Phe Met Gly Ile Leu Ser Trp Lys Asp Ser Lys His Ser Leu 
    210                 215                 220                 


Asn Asn Glu Lys Ile Ile Leu Arg Gly Cys Ile Leu Arg Asn Thr Ser 
225                 230                 235                 240 


Trp Cys Phe Gly Met Val Ile Phe Ala Gly Pro Asp Thr Lys Leu Met 
                245                 250                 255     


Gln Asn Ser Gly Lys Thr Lys Phe Lys Arg Thr Ser Ile Asp Arg Leu 
            260                 265                 270         


Met Asn Thr Leu Val Leu Trp Ile Phe Gly Phe Leu Ile Cys Leu Gly 
        275                 280                 285             


Ile Ile Leu Ala Ile Gly Asn Ser Ile Trp Glu Ser Gln Thr Gly Asp 
    290                 295                 300                 


Gln Phe Arg Thr Phe Leu Phe Trp Asn Glu Gly Glu Lys Ser Ser Val 
305                 310                 315                 320 


Phe Ser Gly Phe Leu Thr Phe Trp Ser Tyr Ile Ile Ile Leu Asn Thr 
                325                 330                 335     


Val Val Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu Gly 
            340                 345                 350         


His Ser Tyr Phe Ile Asn Trp Asp Arg Lys Met Tyr Tyr Ser Arg Lys 
        355                 360                 365             


Ala Ile Pro Ala Val Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu Gly 
    370                 375                 380                 


Gln Ile Glu Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn 
385                 390                 395                 400 


Ile Met Thr Phe Lys Arg Cys Ser Ile Asn Gly Arg Ile Tyr Gly Glu 
                405                 410                 415     


Val His Asp Asp Leu Asp Gln Lys Thr Glu Ile Thr Gln Glu Lys Glu 
            420                 425                 430         


Pro Val Asp Phe Ser Val Lys Ser Gln Ala Asp Arg Glu Phe Gln Phe 
        435                 440                 445             


Phe Asp His His Leu Met Glu Ser Ile Lys Met Gly Asp Pro Lys Val 
    450                 455                 460                 


His Glu Phe Leu Arg Leu Leu Ala Leu Cys His Thr Val Met Ser Glu 
465                 470                 475                 480 


Glu Asn Ser Ala Gly Glu Leu Ile Tyr Gln Val Gln Ser Pro Asp Glu 
                485                 490                 495     


Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Ile Phe Lys Ser 
            500                 505                 510         


Arg Thr Pro Glu Thr Ile Thr Ile Glu Glu Leu Gly Thr Leu Val Thr 
        515                 520                 525             


Tyr Gln Leu Leu Ala Phe Leu Asp Phe Asn Asn Thr Arg Lys Arg Met 
    530                 535                 540                 


Ser Val Ile Val Arg Asn Pro Glu Gly Gln Ile Lys Leu Tyr Ser Lys 
545                 550                 555                 560 


Gly Ala Asp Thr Ile Leu Phe Glu Lys Leu His Pro Ser Asn Glu Val 
                565                 570                 575     


Leu Leu Ser Leu Thr Ser Asp His Leu Ser Glu Phe Ala Gly Glu Gly 
            580                 585                 590         


Leu Arg Thr Leu Ala Ile Ala Tyr Arg Asp Leu Asp Asp Lys Tyr Phe 
        595                 600                 605             


Lys Glu Trp His Lys Met Leu Glu Asp Ala Asn Ala Ala Thr Glu Glu 
    610                 615                 620                 


Arg Asp Glu Arg Ile Ala Gly Leu Tyr Glu Glu Ile Glu Arg Asp Leu 
625                 630                 635                 640 


Met Leu Leu Gly Ala Thr Ala Val Glu Asp Lys Leu Gln Glu Gly Val 
                645                 650                 655     


Ile Glu Thr Val Thr Ser Leu Ser Leu Ala Asn Ile Lys Ile Trp Val 
            660                 665                 670         


Leu Thr Gly Asp Lys Gln Glu Thr Ala Ile Asn Ile Gly Tyr Ala Cys 
        675                 680                 685             


Asn Met Leu Thr Asp Asp Met Asn Asp Val Phe Val Ile Ala Gly Asn 
    690                 695                 700                 


Asn Ala Val Glu Val Arg Glu Glu Leu Arg Lys Ala Lys Gln Asn Leu 
705                 710                 715                 720 


Phe Gly Gln Asn Arg Asn Phe Ser Asn Gly His Val Val Cys Glu Lys 
                725                 730                 735     


Lys Gln Gln Leu Glu Leu Asp Ser Ile Val Glu Glu Thr Ile Thr Gly 
            740                 745                 750         


Asp Tyr Ala Leu Ile Ile Asn Gly His Ser Leu Ala His Ala Leu Glu 
        755                 760                 765             


Ser Asp Val Lys Asn Asp Leu Leu Glu Leu Ala Cys Met Cys Lys Thr 
    770                 775                 780                 


Val Ile Cys Cys Arg Val Thr Pro Leu Gln Lys Ala Gln Val Val Glu 
785                 790                 795                 800 


Leu Val Lys Lys Tyr Arg Asn Ala Val Thr Leu Ala Ile Gly Asp Gly 
                805                 810                 815     


Ala Asn Asp Val Ser Met Ile Lys Ser Ala His Ile Gly Val Gly Ile 
            820                 825                 830         


Ser Gly Gln Glu Gly Leu Gln Ala Val Leu Ala Ser Asp Tyr Ser Phe 
        835                 840                 845             


Ala Gln Phe Arg Tyr Leu Gln Arg Leu Leu Leu Val His Gly Arg Trp 
    850                 855                 860                 


Ser Tyr Phe Arg Met Cys Lys Phe Leu Cys Tyr Phe Phe Tyr Lys Asn 
865                 870                 875                 880 


Phe Ala Phe Thr Leu Val His Phe Trp Phe Gly Phe Phe Cys Gly Phe 
                885                 890                 895     


Ser Ala Gln Thr Val Tyr Asp Gln Trp Phe Ile Thr Leu Phe Asn Ile 
            900                 905                 910         


Val Tyr Thr Ser Leu Pro Val Leu Ala Met Gly Ile Phe Asp Gln Asp 
        915                 920                 925             


Val Ser Asp Gln Asn Ser Val Asp Cys Pro Gln Leu Tyr Lys Pro Gly 
    930                 935                 940                 


Gln Leu Asn Leu Leu Phe Asn Lys Arg Lys Phe Phe Ile Cys Val Leu 
945                 950                 955                 960 


His Gly Ile Tyr Thr Ser Leu Val Leu Phe Phe Ile Pro Tyr Gly Ala 
                965                 970                 975     


Phe Tyr Asn Val Ala Gly Glu Asp Gly Gln His Ile Ala Asp Tyr Gln 
            980                 985                 990         


Ser Phe Ala Val Thr Met Ala Thr  Ser Leu Val Ile Val  Val Ser Val 
        995                 1000                 1005             


Gln Ile  Ala Leu Asp Thr Ser  Tyr Trp Thr Phe Ile  Asn His Val 
    1010                 1015                 1020             


Phe Ile  Trp Gly Ser Ile Ala  Ile Tyr Phe Ser Ile  Leu Phe Thr 
    1025                 1030                 1035             


Met His  Ser Asn Gly Ile Phe  Gly Ile Phe Pro Asn  Gln Phe Pro 
    1040                 1045                 1050             


Phe Val  Gly Asn Ala Arg His  Ser Leu Thr Gln Lys  Cys Ile Trp 
    1055                 1060                 1065             


Leu Val  Ile Leu Leu Thr Thr  Val Ala Ser Val Met  Pro Val Val 
    1070                 1075                 1080             


Ala Phe  Arg Phe Leu Lys Val  Asp Leu Tyr Pro Thr  Leu Ser Asp 
    1085                 1090                 1095             


Gln Ile  Arg Arg Trp Gln Lys  Ala Gln Lys Lys Ala  Arg Pro Pro 
    1100                 1105                 1110             


Ser Ser  Arg Arg Pro Arg Thr  Arg Arg Ser Ser Ser  Arg Arg Ser 
    1115                 1120                 1125             


Gly Tyr  Ala Phe Ala His Gln  Glu Gly Tyr Gly Glu  Leu Ile Thr 
    1130                 1135                 1140             


Ser Gly  Lys Asn Met Arg Ala  Lys Asn Pro Pro Pro  Thr Ser Gly 
    1145                 1150                 1155             


Leu Glu  Lys Thr His Tyr Asn  Ser Thr Ser Trp Ile  Glu Asn Leu 
    1160                 1165                 1170             


Cys Lys  Lys Thr Thr Asp Thr  Val Ser Ser Phe Ser  Gln Asp Lys 
    1175                 1180                 1185             


Thr Val  Lys Leu 
    1190         


<210>  194
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Gly Lys Lys His Lys Lys His Lys Ser Asp Lys His Leu Tyr Glu 
1               5                   10                  15      


Glu Tyr Val Glu Lys Pro Leu Lys Leu Val Leu Lys Val Gly Gly Asn 
            20                  25                  30          


Glu Val Thr Glu Leu Ser Thr Gly Ser Ser Gly His Asp Ser Ser Leu 
        35                  40                  45              


Phe Glu Asp Lys Asn Asp His Asp Lys His Lys Asp Arg Lys Arg Lys 
    50                  55                  60                  


Lys Arg Lys Lys Gly Glu Lys Gln Ile Pro Gly Glu Glu Lys Gly Arg 
65                  70                  75                  80  


Lys Arg Arg Arg Val Lys Glu Asp Lys Lys Lys Arg Asp Arg Asp Arg 
                85                  90                  95      


Val Glu Asn Glu Ala Glu Lys Asp Leu Gln Cys His Ala Pro Val Arg 
            100                 105                 110         


Leu Asp Leu Pro Pro Glu Lys Pro Leu Thr Ser Ser Leu Ala Lys Gln 
        115                 120                 125             


Glu Glu Val Glu Gln Thr Pro Leu Gln Glu Ala Leu Asn Gln Leu Met 
    130                 135                 140                 


Arg Gln Leu Gln Arg Lys Asp Pro Ser Ala Phe Phe Ser Phe Pro Val 
145                 150                 155                 160 


Thr Asp Phe Ile Ala Pro Gly Tyr Ser Met Ile Ile Lys His Pro Met 
                165                 170                 175     


Asp Phe Ser Thr Met Lys Glu Lys Ile Lys Asn Asn Asp Tyr Gln Ser 
            180                 185                 190         


Ile Glu Glu Leu Lys Asp Asn Phe Lys Leu Met Cys Thr Asn Ala Met 
        195                 200                 205             


Ile Tyr Asn Lys Pro Glu Thr Ile Tyr Tyr Lys Ala Ala Lys Lys Leu 
    210                 215                 220                 


Leu His Ser Gly Met Lys Ile Leu Ser Gln Glu Arg Ile Gln Ser Leu 
225                 230                 235                 240 


Lys Gln Ser Ile Asp Phe Met Ala Asp Leu Gln Lys Thr Arg Lys Gln 
                245                 250                 255     


Lys Asp Gly Thr Asp Thr Ser Gln Ser Gly Glu Asp Gly Gly Cys Trp 
            260                 265                 270         


Gln Arg Glu Arg Glu Asp Ser Gly Asp Ala Glu Ala His Ala Phe Lys 
        275                 280                 285             


Ser Pro Ser Lys Glu Asn Lys Lys Lys Asp Lys Asp Met Leu Glu Asp 
    290                 295                 300                 


Lys Phe Lys Ser Asn Asn Leu Glu Arg Glu Gln Glu Gln Leu Asp Arg 
305                 310                 315                 320 


Ile Val Lys Glu Ser Gly Gly Lys Leu Thr Arg Arg Leu Val Asn Ser 
                325                 330                 335     


Gln Cys Glu Phe Glu Arg Arg Lys Pro Asp Gly Thr Thr Thr Leu Gly 
            340                 345                 350         


Leu Leu His Pro Val Asp Pro Ile Val Gly Glu Pro Gly Tyr Cys Pro 
        355                 360                 365             


Val Arg Leu Gly Met Thr Thr Gly Arg Leu Gln Ser Gly Val Asn Thr 
    370                 375                 380                 


Leu Gln Gly Phe Lys Glu Asp Lys Arg Asn Lys Val Thr Pro Val Leu 
385                 390                 395                 400 


Tyr Leu Asn Tyr Gly Pro Tyr Ser Ser Tyr Ala Pro His Tyr Asp Ser 
                405                 410                 415     


Thr Phe Ala Asn Ile Ser Lys Asp Asp Ser Asp Leu Ile Tyr Ser Thr 
            420                 425                 430         


Tyr Gly Glu Asp Ser Asp Leu Pro Ser Asp Phe Ser Ile His Glu Phe 
        435                 440                 445             


Leu Ala Thr Cys Gln Asp Tyr Pro Tyr Val Met Ala Asp Ser Leu Leu 
    450                 455                 460                 


Asp Val Leu Thr Lys Gly Gly His Ser Arg Thr Leu Gln Glu Met Glu 
465                 470                 475                 480 


Met Ser Leu Pro Glu Asp Glu Gly His Thr Arg Thr Leu Asp Thr Ala 
                485                 490                 495     


Lys Glu Met Glu Ile Thr Glu Val Glu Pro Pro Gly Arg Leu Asp Ser 
            500                 505                 510         


Ser Thr Gln Asp Arg Leu Ile Ala Leu Lys Ala Val Thr Asn Phe Gly 
        515                 520                 525             


Val Pro Val Glu Val Phe Asp Ser Glu Glu Ala Glu Ile Phe Gln Lys 
    530                 535                 540                 


Lys Leu Asp Glu Thr Thr Arg Leu Leu Arg Glu Leu Gln Glu Ala Gln 
545                 550                 555                 560 


Asn Glu Arg Leu Ser Thr Arg Pro Pro Pro Asn Met Ile Cys Leu Leu 
                565                 570                 575     


Gly Pro Ser Tyr Arg Glu Met His Leu Ala Glu Gln Val Thr Asn Asn 
            580                 585                 590         


Leu Lys Glu Leu Ala Gln Gln Val Thr Pro Gly Asp Ile Val Ser Thr 
        595                 600                 605             


Tyr Gly Val Arg Lys Ala Met Gly Ile Ser Ile Pro Ser Pro Val Met 
    610                 615                 620                 


Glu Asn Asn Phe Val Asp Leu Thr Glu Asp Thr Glu Glu Pro Lys Lys 
625                 630                 635                 640 


Thr Asp Val Ala Glu Cys Gly Pro Gly Gly Ser 
                645                 650     


<210>  195
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Ser His Gly Lys Gly Thr Asp Met Leu Pro Glu Ile Ala Ala Ala 
1               5                   10                  15      


Val Gly Phe Leu Ser Ser Leu Leu Arg Thr Arg Gly Cys Val Ser Glu 
            20                  25                  30          


Gln Arg Leu Lys Val Phe Ser Gly Ala Leu Gln Glu Ala Leu Thr Glu 
        35                  40                  45              


His Tyr Lys His His Trp Phe Pro Glu Lys Pro Ser Lys Gly Ser Gly 
    50                  55                  60                  


Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Ile Ile Ser Arg 
65                  70                  75                  80  


Val Ala Ser Gln Ile Gly Leu Ser Gln Pro Gln Leu His Gln Leu Leu 
                85                  90                  95      


Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val Ser Tyr Arg 
            100                 105                 110         


Ile Gly Glu Asp Gly Ser Ile Cys Val Leu Tyr Glu Glu Ala Pro Leu 
        115                 120                 125             


Ala Ala Ser Cys Gly Leu Leu Thr Cys Lys Asn Gln Val Leu Leu Gly 
    130                 135                 140                 


Arg Ser Ser Pro Ser Lys Asn Tyr Val Met Ala Val Ser Ser 
145                 150                 155             


<210>  196
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Val Leu Leu His Val Lys Arg Gly Asp Glu Ser Gln Phe Leu Leu 
1               5                   10                  15      


Gln Ala Pro Gly Ser Thr Glu Leu Glu Glu Leu Thr Val Gln Val Ala 
            20                  25                  30          


Arg Val Tyr Asn Gly Arg Leu Lys Val Gln Arg Leu Cys Ser Glu Met 
        35                  40                  45              


Glu Glu Leu Ala Glu His Gly Ile Phe Leu Pro Pro Asn Met Gln Gly 
    50                  55                  60                  


Leu Thr Asp Asp Gln Ile Glu Glu Leu Lys Leu Lys Asp Glu Trp Gly 
65                  70                  75                  80  


Glu Lys Cys Val Pro Ser Gly Gly Ala Val Phe Lys Lys Asp Asp Ile 
                85                  90                  95      


Gly Arg Arg Asn Gly Gln Ala Pro Asn Glu Lys Met Lys Gln Val Leu 
            100                 105                 110         


Lys Lys Thr Ile Glu Glu Ala Lys Ala Ile Ile Ser Lys Lys Gln Val 
        115                 120                 125             


Glu Ala Gly Val Cys Val Thr Met Glu Met Val Lys Asp Ala Leu Asp 
    130                 135                 140                 


Gln Leu Arg Gly Ala Val Met Ile Val Tyr Pro Met Gly Leu Pro Pro 
145                 150                 155                 160 


Tyr Asp Pro Ile Arg Met Glu Phe Glu Asn Lys Glu Asp Leu Ser Gly 
                165                 170                 175     


Thr Gln Ala Gly Leu Asn Val Ile Lys Glu Ala Glu Ala Gln Leu Trp 
            180                 185                 190         


Trp Ala Ala Lys Glu Leu Arg Arg Thr Lys Lys Leu Ser Asp Tyr Val 
        195                 200                 205             


Gly Lys Asn Glu Lys Thr Lys Ile Ile Ala Lys Ile Gln Gln Arg Gly 
    210                 215                 220                 


Gln Gly Ala Pro Ala Arg Glu Pro Ile Ile Ser Ser Glu Glu Gln Lys 
225                 230                 235                 240 


Gln Leu Met Leu Tyr Tyr His Arg Arg Gln Glu Glu Leu Lys Arg Leu 
                245                 250                 255     


Glu Glu Asn Asp Asp Asp Ala Tyr Leu Asn Ser Pro Trp Ala Asp Asn 
            260                 265                 270         


Thr Ala Leu Lys Arg His Phe His Gly Val Lys Asp Ile Lys Trp Arg 
        275                 280                 285             


Pro Arg 
    290 


<210>  197
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Glu Arg Ser Phe Val Trp Leu Ser Cys Leu Asp Ser Asp Ser Cys 
1               5                   10                  15      


Asn Leu Thr Phe Arg Leu Gly Glu Val Glu Ser His Ala Cys Ser Pro 
            20                  25                  30          


Ser Leu Leu Trp Asn Leu Leu Thr Gln Tyr Leu Pro Pro Gly Ala Gly 
        35                  40                  45              


His Ile Leu Arg Thr Tyr Asn Phe Pro Val Leu Ser Cys Val Ser Ser 
    50                  55                  60                  


Cys His Leu Ile Gly Gly Lys Met Pro Glu Asn 
65                  70                  75  


<210>  198
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Glu Leu Leu Cys His Glu Val Asp Pro Val Arg Arg Ala Val Arg 
1               5                   10                  15      


Asp Arg Asn Leu Leu Arg Asp Asp Arg Val Leu Gln Asn Leu Leu Thr 
            20                  25                  30          


Ile Glu Glu Arg Tyr Leu Pro Gln Cys Ser Tyr Phe Lys Cys Val Gln 
        35                  40                  45              


Lys Asp Ile Gln Pro Tyr Met Arg Arg Met Val Ala Thr Trp Met Leu 
    50                  55                  60                  


Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu Ala 
65                  70                  75                  80  


Met Asn Tyr Leu Asp Arg Phe Leu Ala Gly Val Pro Thr Pro Lys Ser 
                85                  90                  95      


His Leu Gln Leu Leu Gly Ala Val Cys Met Phe Leu Ala Ser Lys Leu 
            100                 105                 110         


Lys Glu Thr Ser Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr Asp 
        115                 120                 125             


Asn Ser Ile Lys Pro Gln Glu Leu Leu Glu Trp Glu Leu Val Val Leu 
    130                 135                 140                 


Gly Lys Leu Lys Trp Asn Leu Ala Ala Val Thr Pro His Asp Phe Ile 
145                 150                 155                 160 


Glu His Ile Leu Arg Lys Leu Pro Gln Gln Arg Glu Lys Leu Ser Leu 
                165                 170                 175     


Ile Arg Lys His Ala Gln Thr Phe Ile Ala Leu Cys Ala Thr Asp Phe 
            180                 185                 190         


Lys Phe Ala Met Tyr Pro Pro Ser Met Ile Ala Thr Gly Ser Val Gly 
        195                 200                 205             


Ala Ala Ile Cys Gly Leu Gln Gln Asp Glu Glu Val Ser Ser Leu Thr 
    210                 215                 220                 


Cys Asp Ala Leu Thr Glu Leu Leu Ala Lys Ile Thr Asn Thr Asp Val 
225                 230                 235                 240 


Asp Cys Leu Lys Ala Cys Gln Glu Gln Ile Glu Ala Val Leu Leu Asn 
                245                 250                 255     


Ser Leu Gln Gln Tyr Arg Gln Asp Gln Arg Asp Gly Ser Lys Ser Glu 
            260                 265                 270         


Asp Glu Leu Asp Gln Ala Ser Thr Pro Thr Asp Val Arg Asp Ile Asp 
        275                 280                 285             


Leu 
    


<210>  199
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  200
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  201
<211>  594
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Ala Ala Glu Ser Gly Glu Leu Ile Gly Ala Cys Glu Phe Met Lys 
1               5                   10                  15      


Asp Arg Leu Tyr Phe Ala Thr Leu Arg Asn Arg Pro Lys Ser Thr Val 
            20                  25                  30          


Asn Thr His Tyr Phe Ser Ile Asp Glu Glu Leu Val Tyr Glu Asn Phe 
        35                  40                  45              


Tyr Ala Asp Phe Gly Pro Leu Asn Leu Ala Met Val Tyr Arg Tyr Cys 
    50                  55                  60                  


Cys Lys Leu Asn Lys Lys Leu Lys Ser Tyr Ser Leu Ser Arg Lys Lys 
65                  70                  75                  80  


Ile Val His Tyr Thr Cys Phe Asp Gln Arg Lys Arg Ala Asn Ala Ala 
                85                  90                  95      


Phe Leu Ile Gly Ala Tyr Ala Val Ile Tyr Leu Lys Lys Thr Pro Glu 
            100                 105                 110         


Glu Ala Tyr Arg Ala Leu Leu Ser Gly Ser Asn Pro Pro Tyr Leu Pro 
        115                 120                 125             


Phe Arg Asp Ala Ser Phe Gly Asn Cys Thr Tyr Asn Leu Thr Ile Leu 
    130                 135                 140                 


Asp Cys Leu Gln Gly Ile Arg Lys Gly Leu Gln His Gly Phe Phe Asp 
145                 150                 155                 160 


Phe Glu Thr Phe Asp Val Asp Glu Tyr Glu His Tyr Glu Arg Val Glu 
                165                 170                 175     


Asn Gly Asp Phe Asn Trp Ile Val Pro Gly Lys Phe Leu Ala Phe Ser 
            180                 185                 190         


Gly Pro His Pro Lys Ser Lys Ile Glu Asn Gly Tyr Pro Leu His Ala 
        195                 200                 205             


Pro Glu Ala Tyr Phe Pro Tyr Phe Lys Lys His Asn Val Thr Ala Val 
    210                 215                 220                 


Val Arg Leu Asn Lys Lys Ile Tyr Glu Ala Lys Arg Phe Thr Asp Ala 
225                 230                 235                 240 


Gly Phe Glu His Tyr Asp Leu Phe Phe Ile Asp Gly Ser Thr Pro Ser 
                245                 250                 255     


Asp Asn Ile Val Arg Arg Phe Leu Asn Ile Cys Glu Asn Thr Glu Gly 
            260                 265                 270         


Ala Ile Ala Val His Cys Lys Ala Gly Leu Gly Arg Thr Gly Thr Leu 
        275                 280                 285             


Ile Ala Cys Tyr Val Met Lys His Tyr Arg Phe Thr His Ala Glu Ile 
    290                 295                 300                 


Ile Ala Trp Ile Arg Ile Cys Arg Pro Gly Ser Ile Ile Gly Pro Gln 
305                 310                 315                 320 


Gln His Phe Leu Glu Glu Lys Gln Ala Ser Leu Trp Val Gln Gly Asp 
                325                 330                 335     


Ile Phe Arg Ser Lys Leu Lys Asn Arg Pro Ser Ser Glu Gly Ser Ile 
            340                 345                 350         


Asn Lys Ile Leu Ser Gly Leu Asp Asp Met Ser Ile Gly Gly Asn Leu 
        355                 360                 365             


Ser Lys Thr Gln Asn Met Glu Arg Phe Gly Glu Asp Asn Leu Glu Asp 
    370                 375                 380                 


Asp Asp Val Glu Met Lys Asn Gly Ile Thr Gln Gly Asp Lys Leu Arg 
385                 390                 395                 400 


Ala Leu Lys Ser Gln Arg Gln Pro Arg Thr Ser Pro Ser Cys Ala Phe 
                405                 410                 415     


Arg Ser Asp Asp Thr Lys Gly His Pro Arg Ala Val Ser Gln Pro Phe 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Gln Gly Ser Ala Val Thr Leu Lys Thr Ser 
        435                 440                 445             


Lys Met Ala Leu Ser Pro Ser Ala Thr Ala Lys Arg Ile Asn Arg Thr 
    450                 455                 460                 


Ser Leu Ser Ser Gly Ala Thr Val Arg Ser Phe Ser Ile Asn Ser Arg 
465                 470                 475                 480 


Leu Ala Ser Ser Leu Gly Asn Leu Asn Ala Ala Thr Asp Asp Pro Glu 
                485                 490                 495     


Asn Lys Lys Thr Ser Ser Ser Ser Lys Ala Gly Phe Thr Ala Ser Pro 
            500                 505                 510         


Phe Thr Asn Leu Leu Asn Gly Ser Ser Gln Pro Thr Thr Arg Asn Tyr 
        515                 520                 525             


Pro Glu Leu Asn Asn Asn Gln Tyr Asn Arg Ser Ser Asn Ser Asn Gly 
    530                 535                 540                 


Gly Asn Leu Asn Ser Pro Pro Gly Pro His Ser Ala Lys Thr Glu Glu 
545                 550                 555                 560 


His Thr Thr Ile Leu Arg Pro Ser Tyr Thr Gly Leu Ser Ser Ser Ser 
                565                 570                 575     


Ala Arg Phe Leu Ser Arg Ser Ile Pro Ser Leu Gln Ser Glu Tyr Val 
            580                 585                 590         


His Tyr 
        


<210>  202
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Gly Ala Thr Gly Ala Ala Glu Pro Leu Gln Ser Val Leu Trp Val 
1               5                   10                  15      


Lys Gln Gln Arg Cys Ala Val Ser Leu Glu Pro Ala Arg Ala Leu Leu 
            20                  25                  30          


Arg Trp Trp Arg Ser Pro Gly Pro Gly Ala Gly Ala Pro Gly Ala Asp 
        35                  40                  45              


Ala Cys Ser Val Pro Val Ser Glu Ile Ile Ala Val Glu Glu Thr Asp 
    50                  55                  60                  


Val His Gly Lys His Gln Gly Ser Gly Lys Trp Gln Lys Met Glu Lys 
65                  70                  75                  80  


Pro Tyr Ala Phe Thr Val His Cys Val Lys Arg Ala Arg Arg His Arg 
                85                  90                  95      


Trp Lys Trp Ala Gln Val Thr Phe Trp Cys Pro Glu Glu Gln Leu Cys 
            100                 105                 110         


His Leu Trp Leu Gln Thr Leu Arg Glu Met Leu Glu Lys Leu Thr Ser 
        115                 120                 125             


Arg Pro Lys His Leu Leu Val Phe Ile Asn Pro Phe Gly Gly Lys Gly 
    130                 135                 140                 


Gln Gly Lys Arg Ile Tyr Glu Arg Lys Val Ala Pro Leu Phe Thr Leu 
145                 150                 155                 160 


Ala Ser Ile Thr Thr Asp Ile Ile Val Thr Glu His Ala Asn Gln Ala 
                165                 170                 175     


Lys Glu Thr Leu Tyr Glu Ile Asn Ile Asp Lys Tyr Asp Gly Ile Val 
            180                 185                 190         


Cys Val Gly Gly Asp Gly Met Phe Ser Glu Val Leu His Gly Leu Ile 
        195                 200                 205             


Gly Arg Thr Gln Arg Ser Ala Gly Val Asp Gln Asn His Pro Arg Ala 
    210                 215                 220                 


Val Leu Val Pro Ser Ser Leu Arg Ile Gly Ile Ile Pro Ala Gly Ser 
225                 230                 235                 240 


Thr Asp Cys Val Cys Tyr Ser Thr Val Gly Thr Ser Asp Ala Glu Thr 
                245                 250                 255     


Ser Ala Leu His Ile Val Val Gly Asp Ser Leu Ala Met Asp Val Ser 
            260                 265                 270         


Ser Val His His Asn Ser Thr Leu Leu Arg Tyr Ser Val Ser Leu Leu 
        275                 280                 285             


Gly Tyr Gly Phe Tyr Gly Asp Ile Ile Lys Asp Ser Glu Lys Lys Arg 
    290                 295                 300                 


Trp Leu Gly Leu Ala Arg Tyr Asp Phe Ser Gly Leu Lys Thr Phe Leu 
305                 310                 315                 320 


Ser His His Cys Tyr Glu Gly Thr Val Ser Phe Leu Pro Ala Gln His 
                325                 330                 335     


Thr Val Gly Ser Pro Arg Asp Arg Lys Pro Cys Arg Ala Gly Cys Phe 
            340                 345                 350         


Val Cys Arg Gln Ser Lys Gln Gln Leu Glu Glu Glu Gln Lys Lys Ala 
        355                 360                 365             


Leu Tyr Gly Leu Glu Ala Ala Glu Asp Val Glu Glu Trp Gln Val Val 
    370                 375                 380                 


Cys Gly Lys Phe Leu Ala Ile Asn Ala Thr Asn Met Ser Cys Ala Cys 
385                 390                 395                 400 


Arg Arg Ser Pro Arg Gly Leu Ser Pro Ala Ala His Leu Gly Asp Gly 
                405                 410                 415     


Ser Ser Asp Leu Ile Leu Ile Arg Lys Cys Ser Arg Phe Asn Phe Leu 
            420                 425                 430         


Arg Phe Leu Ile Arg His Thr Asn Gln Gln Asp Gln Phe Asp Phe Thr 
        435                 440                 445             


Phe Val Glu Val Tyr Arg Val Lys Lys Phe Gln Phe Thr Ser Lys His 
    450                 455                 460                 


Met Glu Asp Glu Asp Ser Asp Leu Lys Glu Gly Gly Lys Lys Arg Phe 
465                 470                 475                 480 


Gly His Ile Cys Ser Ser His Pro Ser Cys Cys Cys Thr Val Ser Asn 
                485                 490                 495     


Ser Ser Trp Asn Cys Asp Gly Glu Val Leu His Ser Pro Ala Ile Glu 
            500                 505                 510         


Val Arg Val His Cys Gln Leu Val Arg Leu Phe Ala Arg Gly Ile Glu 
        515                 520                 525             


Glu Asn Pro Lys Pro Asp Ser His Ser 
    530                 535         


<210>  203
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Ala Ala Gly Ala Gly Ala Gly Ser Ala Pro Arg Trp Leu Arg Ala 
1               5                   10                  15      


Leu Ser Glu Pro Leu Ser Ala Ala Gln Leu Arg Arg Leu Glu Glu His 
            20                  25                  30          


Arg Tyr Ser Ala Ala Gly Val Ser Leu Leu Glu Pro Pro Leu Gln Leu 
        35                  40                  45              


Tyr Trp Thr Trp Leu Leu Gln Trp Ile Pro Leu Trp Met Ala Pro Asn 
    50                  55                  60                  


Ser Ile Thr Leu Leu Gly Leu Ala Val Asn Val Val Thr Thr Leu Val 
65                  70                  75                  80  


Leu Ile Ser Tyr Cys Pro Thr Ala Thr Glu Glu Ala Pro Tyr Trp Thr 
                85                  90                  95      


Tyr Leu Leu Cys Ala Leu Gly Leu Phe Ile Tyr Gln Ser Leu Asp Ala 
            100                 105                 110         


Ile Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Cys Ser Pro Leu Gly 
        115                 120                 125             


Glu Leu Phe Asp His Gly Cys Asp Ser Leu Ser Thr Val Phe Met Ala 
    130                 135                 140                 


Val Gly Ala Ser Ile Ala Ala Arg Leu Gly Thr Tyr Pro Asp Trp Phe 
145                 150                 155                 160 


Phe Phe Cys Ser Phe Ile Gly Met Phe Val Phe Tyr Cys Ala His Trp 
                165                 170                 175     


Gln Thr Tyr Val Ser Gly Met Leu Arg Phe Gly Lys Val Asp Val Thr 
            180                 185                 190         


Glu Ile Gln Ile Ala Leu Val Ile Val Phe Val Leu Ser Ala Phe Gly 
        195                 200                 205             


Gly Ala Thr Met Trp Asp Tyr Thr Ile Pro Ile Leu Glu Ile Lys Leu 
    210                 215                 220                 


Lys Ile Leu Pro Val Leu Gly Phe Leu Gly Gly Val Ile Phe Ser Cys 
225                 230                 235                 240 


Ser Asn Tyr Phe His Val Ile Leu His Gly Gly Val Gly Lys Asn Gly 
                245                 250                 255     


Ser Thr Ile Ala Gly Thr Ser Val Leu Ser Pro Gly Leu His Ile Gly 
            260                 265                 270         


Leu Ile Ile Ile Leu Ala Ile Met Ile Tyr Lys Lys Ser Ala Thr Asp 
        275                 280                 285             


Val Phe Glu Lys His Pro Cys Leu Tyr Ile Leu Met Phe Gly Cys Val 
    290                 295                 300                 


Phe Ala Lys Val Ser Gln Lys Leu Val Val Ala His Met Thr Lys Ser 
305                 310                 315                 320 


Glu Leu Tyr Leu Gln Asp Thr Val Phe Leu Gly Pro Gly Leu Leu Phe 
                325                 330                 335     


Leu Asp Gln Tyr Phe Asn Asn Phe Ile Asp Glu Tyr Val Val Leu Trp 
            340                 345                 350         


Met Ala Met Val Ile Ser Ser Phe Asp Met Val Ile Tyr Phe Ser Ala 
        355                 360                 365             


Leu Cys Leu Gln Ile Ser Arg His Leu His Leu Asn Ile Phe Lys Thr 
    370                 375                 380                 


Ala Cys His Gln Ala Pro Glu Gln Val Gln Val Leu Ser Ser Lys Ser 
385                 390                 395                 400 


His Gln Asn Asn Met Asp 
                405     


<210>  204
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Asn Ser Ser Lys Ser Ser Glu Thr Gln Cys Thr Glu Arg Gly Cys 
1               5                   10                  15      


Phe Ser Ser Gln Met Phe Leu Trp Thr Val Ala Gly Ile Pro Ile Leu 
            20                  25                  30          


Phe Leu Ser Ala Cys Phe Ile Thr Arg Cys Val Val Thr Phe Arg Ile 
        35                  40                  45              


Phe Gln Thr Cys Asp Glu Lys Lys Phe Gln Leu Pro Glu Asn Phe Thr 
    50                  55                  60                  


Glu Leu Ser Cys Tyr Asn Tyr Gly Ser Gly Ser Val Lys Asn Cys Cys 
65                  70                  75                  80  


Pro Leu Asn Trp Glu Tyr Phe Gln Ser Ser Cys Tyr Phe Phe Ser Thr 
                85                  90                  95      


Asp Thr Ile Ser Trp Ala Leu Ser Leu Lys Asn Cys Ser Ala Met Gly 
            100                 105                 110         


Ala His Leu Val Val Ile Asn Ser Gln Glu Glu Gln Glu Phe Leu Ser 
        115                 120                 125             


Tyr Lys Lys Pro Lys Met Arg Glu Phe Phe Ile Gly Leu Ser Asp Gln 
    130                 135                 140                 


Val Val Glu Gly Gln Trp Gln Trp Val Asp Gly Thr Pro Leu Thr Lys 
145                 150                 155                 160 


Ser Leu Ser Phe Trp Asp Val Gly Glu Pro Asn Asn Ile Ala Thr Leu 
                165                 170                 175     


Glu Asp Cys Ala Thr Met Arg Asp Ser Ser Asn Pro Arg Gln Asn Trp 
            180                 185                 190         


Asn Asp Val Thr Cys Phe Leu Asn Tyr Phe Arg Ile Cys Glu Met Val 
        195                 200                 205             


Gly Ile Asn Pro Leu Asn Lys Gly Lys Ser Leu 
    210                 215                 


<210>  205
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu Leu Thr Trp Glu 
1               5                   10                  15      


Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp Asn Glu Leu Gln 
            20                  25                  30          


Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys Glu Ile Gln Asn 
        35                  40                  45              


Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile Glu Lys Thr Asn 
    50                  55                  60                  


Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu Ala Lys Lys Lys 
65                  70                  75                  80  


Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu Thr Lys Leu Lys 
                85                  90                  95      


Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala Leu Trp Glu Glu 
            100                 105                 110         


Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe Tyr Ala Arg Val 
        115                 120                 125             


Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu Glu Glu Phe Leu 
    130                 135                 140                 


Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly Asp Arg Ile Asp 
145                 150                 155                 160 


Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met Leu Asp Val Met 
                165                 170                 175     


Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp Glu Leu Phe Gln 
            180                 185                 190         


Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr His Tyr Leu Pro 
        195                 200                 205             


Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe Pro Lys Ser Arg 
    210                 215                 220                 


Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu Pro Leu Asn Phe 
225                 230                 235                 240 


His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His Glu Ala Gln Gln 
                245                 250                 255     


Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln His Pro Pro Thr 
            260                 265                 270         


Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val Cys Arg Glu Ile 
        275                 280                 285             


Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp Gln Cys Asp Lys 
    290                 295                 300                 


Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn Asn Pro Ser Gln 
305                 310                 315                 320 


Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln Val Ala Glu Arg 
                325                 330                 335     


Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr Gln Trp Lys Met 
            340                 345                 350         


Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu Gln Phe Asn Trp 
        355                 360                 365             


Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp Gln Tyr Tyr Leu 
    370                 375                 380                 


Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser Asp Val Pro Ser 
385                 390                 395                 400 


Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser Asp Pro Ile Thr 
                405                 410                 415     


Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro Lys Phe Met Glu 
            420                 425                 430         


Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys Lys His Arg Glu 
        435                 440                 445             


Glu 
    


<210>  206
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Ser Ser Asn Glu Cys Phe Lys Cys Gly Arg Ser Gly His Trp Ala 
1               5                   10                  15      


Arg Glu Cys Pro Thr Gly Gly Gly Arg Gly Arg Gly Met Arg Ser Arg 
            20                  25                  30          


Gly Arg Gly Gly Phe Thr Ser Asp Arg Gly Phe Gln Phe Val Ser Ser 
        35                  40                  45              


Ser Leu Pro Asp Ile Cys Tyr Arg Cys Gly Glu Ser Gly His Leu Ala 
    50                  55                  60                  


Lys Asp Cys Asp Leu Gln Glu Asp Ala Cys Tyr Asn Cys Gly Arg Gly 
65                  70                  75                  80  


Gly His Ile Ala Lys Asp Cys Lys Glu Pro Lys Arg Glu Arg Glu Gln 
                85                  90                  95      


Cys Cys Tyr Asn Cys Gly Lys Pro Gly His Leu Ala Arg Asp Cys Asp 
            100                 105                 110         


His Ala Asp Glu Gln Lys Cys Tyr Ser Cys Gly Glu Phe Gly His Ile 
        115                 120                 125             


Gln Lys Asp Cys Thr Lys Val Lys Cys Tyr Arg Cys Gly Glu Thr Gly 
    130                 135                 140                 


His Val Ala Ile Asn Cys Ser Lys Thr Ser Glu Val Asn Cys Tyr Arg 
145                 150                 155                 160 


Cys Gly Glu Ser Gly His Leu Ala Arg Glu Cys Thr Ile Glu Ala Thr 
                165                 170                 175     


Ala 
    


<210>  207
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Arg Phe Arg Phe Cys Gly Asp Leu Asp Cys Pro Asp Trp Val Leu 
1               5                   10                  15      


Ala Glu Ile Ser Thr Leu Ala Lys Met Ser Ser Val Lys Leu Arg Leu 
            20                  25                  30          


Leu Cys Ser Gln Val Leu Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr 
        35                  40                  45              


Glu Lys Ile Leu Lys Leu Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp 
    50                  55                  60                  


Val Lys Ala Thr Val Ala Val Leu Ser Phe Ile Leu Ser Ser Ala Ala 
65                  70                  75                  80  


Lys His Ser Val Asp Gly Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu 
                85                  90                  95      


Gly Leu Pro Lys Glu His Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu 
            100                 105                 110         


Lys Gln Ser Pro Leu Gln Lys His Leu Arg Val Cys Ser Leu Arg Met 
        115                 120                 125             


Asn Arg Leu Ala Gly Val Gly Trp Arg Val Asp Tyr Thr Leu Ser Ser 
    130                 135                 140                 


Ser Leu Leu Gln Ser Val Glu Glu Pro Met Val His Leu Arg Leu Glu 
145                 150                 155                 160 


Val Ala Ala Ala Pro Gly Thr Pro Ala Gln Pro Val Ala Met Ser Leu 
                165                 170                 175     


Ser Ala Asp Lys Phe Gln Val Leu Leu Ala Glu Leu Lys Gln Ala Gln 
            180                 185                 190         


Thr Leu Met Ser Ser Leu Gly 
        195                 


<210>  208
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Ala Ala Arg Thr Gly His Thr Ala Leu Arg Arg Val Val Ser Gly 
1               5                   10                  15      


Cys Arg Pro Lys Ser Ala Thr Ala Ala Gly Ala Gln Ala Pro Val Arg 
            20                  25                  30          


Asn Gly Arg Tyr Leu Ala Ser Cys Gly Ile Leu Met Ser Arg Thr Leu 
        35                  40                  45              


Pro Leu His Thr Ser Ile Leu Pro Lys Glu Ile Cys Ala Arg Thr Phe 
    50                  55                  60                  


Phe Lys Ile Thr Ala Pro Leu Ile Asn Lys Arg Lys Glu Tyr Ser Glu 
65                  70                  75                  80  


Arg Arg Ile Leu Gly Tyr Ser Met Gln Glu Met Tyr Asp Val Val Ser 
                85                  90                  95      


Gly Val Glu Asp Tyr Lys His Phe Val Pro Trp Cys Lys Lys Ser Asp 
            100                 105                 110         


Val Ile Ser Lys Arg Ser Gly Tyr Cys Lys Thr Arg Leu Glu Ile Gly 
        115                 120                 125             


Phe Pro Pro Val Leu Glu Arg Tyr Thr Ser Val Val Thr Leu Val Lys 
    130                 135                 140                 


Pro His Leu Val Lys Ala Ser Cys Thr Asp Gly Arg Leu Phe Asn His 
145                 150                 155                 160 


Leu Glu Thr Ile Trp Arg Phe Ser Pro Gly Leu Pro Gly Tyr Pro Arg 
                165                 170                 175     


Thr Cys Thr Leu Asp Phe Ser Ile Ser Phe Glu Phe Arg Ser Leu Leu 
            180                 185                 190         


His Ser Gln Leu Ala Thr Leu Phe Phe Asp Glu Val Val Lys Gln Met 
        195                 200                 205             


Val Ala Ala Phe Glu Arg Arg Ala Cys Lys Leu Tyr Gly Pro Glu Thr 
    210                 215                 220                 


Asn Ile Pro Arg Glu Leu Met Leu His Glu Val His His Thr 
225                 230                 235             


<210>  209
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Ala Ser Arg Leu Leu Arg Gly Ala Gly Thr Leu Ala Ala Gln Ala 
1               5                   10                  15      


Leu Arg Ala Arg Gly Pro Ser Gly Ala Ala Ala Met Arg Ser Met Ala 
            20                  25                  30          


Ser Gly Gly Gly Val Pro Thr Asp Glu Glu Gln Ala Thr Gly Leu Glu 
        35                  40                  45              


Arg Glu Ile Met Leu Ala Ala Lys Lys Gly Leu Asp Pro Tyr Asn Val 
    50                  55                  60                  


Leu Ala Pro Lys Gly Ala Ser Gly Thr Arg Glu Asp Pro Asn Leu Val 
65                  70                  75                  80  


Pro Ser Ile Ser Asn Lys Arg Ile Val Gly Cys Ile Cys Glu Glu Asp 
                85                  90                  95      


Asn Thr Ser Val Val Trp Phe Trp Leu His Lys Gly Glu Ala Gln Arg 
            100                 105                 110         


Cys Pro Arg Cys Gly Ala His Tyr Lys Leu Val Pro Gln Gln Leu Ala 
        115                 120                 125             


His 
    


<210>  210
<211>  476
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Val Gly Ala Met Trp Lys Val Ile Val Ser Leu Val Leu Leu Met 
1               5                   10                  15      


Pro Gly Pro Cys Asp Gly Leu Phe Arg Ser Leu Tyr Arg Ser Val Ser 
            20                  25                  30          


Met Pro Pro Lys Gly Asp Ser Gly Gln Pro Leu Phe Leu Thr Pro Tyr 
        35                  40                  45              


Ile Glu Ala Gly Lys Ile Gln Lys Gly Arg Glu Leu Ser Leu Val Gly 
    50                  55                  60                  


Pro Phe Pro Gly Leu Asn Met Lys Ser Tyr Ala Gly Phe Leu Thr Val 
65                  70                  75                  80  


Asn Lys Thr Tyr Asn Ser Asn Leu Phe Phe Trp Phe Phe Pro Ala Gln 
                85                  90                  95      


Ile Gln Pro Glu Asp Ala Pro Val Val Leu Trp Leu Gln Gly Gly Pro 
            100                 105                 110         


Gly Gly Ser Ser Met Phe Gly Leu Phe Val Glu His Gly Pro Tyr Val 
        115                 120                 125             


Val Thr Ser Asn Met Thr Leu Arg Asp Arg Asp Phe Pro Trp Thr Thr 
    130                 135                 140                 


Thr Leu Ser Met Leu Tyr Ile Asp Asn Pro Val Gly Thr Gly Phe Ser 
145                 150                 155                 160 


Phe Thr Asp Asp Thr His Gly Tyr Ala Val Asn Glu Asp Asp Val Ala 
                165                 170                 175     


Arg Asp Leu Tyr Ser Ala Leu Ile Gln Phe Phe Gln Ile Phe Pro Glu 
            180                 185                 190         


Tyr Lys Asn Asn Asp Phe Tyr Val Thr Gly Glu Ser Tyr Ala Gly Lys 
        195                 200                 205             


Tyr Val Pro Ala Ile Ala His Leu Ile His Ser Leu Asn Pro Val Arg 
    210                 215                 220                 


Glu Val Lys Ile Asn Leu Asn Gly Ile Ala Ile Gly Asp Gly Tyr Ser 
225                 230                 235                 240 


Asp Pro Glu Ser Ile Ile Gly Gly Tyr Ala Glu Phe Leu Tyr Gln Ile 
                245                 250                 255     


Gly Leu Leu Asp Glu Lys Gln Lys Lys Tyr Phe Gln Lys Gln Cys His 
            260                 265                 270         


Glu Cys Ile Glu His Ile Arg Lys Gln Asn Trp Phe Glu Ala Phe Glu 
        275                 280                 285             


Ile Leu Asp Lys Leu Leu Asp Gly Asp Leu Thr Ser Asp Pro Ser Tyr 
    290                 295                 300                 


Phe Gln Asn Val Thr Gly Cys Ser Asn Tyr Tyr Asn Phe Leu Arg Cys 
305                 310                 315                 320 


Thr Glu Pro Glu Asp Gln Leu Tyr Tyr Val Lys Phe Leu Ser Leu Pro 
                325                 330                 335     


Glu Val Arg Gln Ala Ile His Val Gly Asn Gln Thr Phe Asn Asp Gly 
            340                 345                 350         


Thr Ile Val Glu Lys Tyr Leu Arg Glu Asp Thr Val Gln Ser Val Lys 
        355                 360                 365             


Pro Trp Leu Thr Glu Ile Met Asn Asn Tyr Lys Val Leu Ile Tyr Asn 
    370                 375                 380                 


Gly Gln Leu Asp Ile Ile Val Ala Ala Ala Leu Thr Glu Arg Ser Leu 
385                 390                 395                 400 


Met Gly Met Asp Trp Lys Gly Ser Gln Glu Tyr Lys Lys Ala Glu Lys 
                405                 410                 415     


Lys Val Trp Lys Ile Phe Lys Ser Asp Ser Glu Val Ala Gly Tyr Ile 
            420                 425                 430         


Arg Gln Ala Gly Asp Phe His Gln Val Ile Ile Arg Gly Gly Gly His 
        435                 440                 445             


Ile Leu Pro Tyr Asp Gln Pro Leu Arg Ala Phe Asp Met Ile Asn Arg 
    450                 455                 460                 


Phe Ile Tyr Gly Lys Gly Trp Asp Pro Tyr Val Gly 
465                 470                 475     


<210>  211
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  211

Met Glu His Gly Ser Ile Ile Thr Gln Ala Arg Arg Glu Asp Ala Leu 
1               5                   10                  15      


Val Leu Thr Lys Gln Gly Leu Val Ser Lys Ser Ser Pro Lys Lys Pro 
            20                  25                  30          


Arg Gly Arg Asn Ile Phe Lys Ala Leu Phe Cys Cys Phe Arg Ala Gln 
        35                  40                  45              


His Val Gly Gln Ser Ser Ser Ser Thr Glu Leu Ala Ala Tyr Lys Glu 
    50                  55                  60                  


Glu Ala Asn Thr Ile Ala Lys Ser Asp Leu Leu Gln Cys Leu Gln Tyr 
65                  70                  75                  80  


Gln Phe Tyr Gln Ile Pro Gly Thr Cys Leu Leu Pro Glu Val Thr Glu 
                85                  90                  95      


Glu Asp Gln Gly Arg Ile Cys Val Val Ile Asp Leu Asp Glu Thr Leu 
            100                 105                 110         


Val His Ser Ser Phe Lys Pro Ile Asn Asn Ala Asp Phe Ile Val Pro 
        115                 120                 125             


Ile Glu Ile Glu Gly Thr Thr His Gln Val Tyr Val Leu Lys Arg Pro 
    130                 135                 140                 


Tyr Val Asp Glu Phe Leu Arg Arg Met Gly Glu Leu Phe Glu Cys Val 
145                 150                 155                 160 


Leu Phe Thr Ala Ser Leu Ala Lys Tyr Ala Asp Pro Val Thr Asp Leu 
                165                 170                 175     


Leu Asp Arg Cys Gly Val Phe Arg Ala Arg Leu Phe Arg Glu Ser Cys 
            180                 185                 190         


Val Phe His Gln Gly Cys Tyr Val Lys Asp Leu Ser Arg Leu Gly Arg 
        195                 200                 205             


Asp Leu Arg Lys Thr Leu Ile Leu Asp Asn Ser Pro Ala Ser Tyr Ile 
    210                 215                 220                 


Phe His Pro Glu Asn Ala Val Pro Val Gln Ser Trp Phe Asp Asp Met 
225                 230                 235                 240 


Ala Asp Thr Glu Leu Leu Asn Leu Ile Pro Ile Phe Glu Glu Leu Ser 
                245                 250                 255     


Gly Ala Glu Asp Val Tyr Thr Ser Leu Gly Gln Leu Arg Ala Pro 
            260                 265                 270     


<210>  212
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Thr Ser Ser Pro Arg Ala Pro Pro Gly Glu Gln Gly Arg Gly Gly 
1               5                   10                  15      


Ala Glu Met Ile Arg Ala Ala Pro Pro Pro Leu Phe Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Leu Val Ser Trp Ala Ser Arg Gly Glu Ala Ala Pro 
        35                  40                  45              


Asp Gln Asp Glu Ile Gln Arg Leu Pro Gly Leu Ala Lys Gln Pro Ser 
    50                  55                  60                  


Phe Arg Gln Tyr Ser Gly Tyr Leu Lys Gly Ser Gly Ser Lys His Leu 
65                  70                  75                  80  


His Tyr Trp Phe Val Glu Ser Gln Lys Asp Pro Glu Asn Ser Pro Val 
                85                  90                  95      


Val Leu Trp Leu Asn Gly Gly Pro Gly Cys Ser Ser Leu Asp Gly Leu 
            100                 105                 110         


Leu Thr Glu His Gly Pro Phe Leu Val Gln Pro Asp Gly Val Thr Leu 
        115                 120                 125             


Glu Tyr Asn Pro Tyr Ser Trp Asn Leu Ile Ala Asn Val Leu Tyr Leu 
    130                 135                 140                 


Glu Ser Pro Ala Gly Val Gly Phe Ser Tyr Ser Asp Asp Lys Phe Tyr 
145                 150                 155                 160 


Ala Thr Asn Asp Thr Glu Val Ala Gln Ser Asn Phe Glu Ala Leu Gln 
                165                 170                 175     


Asp Phe Phe Arg Leu Phe Pro Glu Tyr Lys Asn Asn Lys Leu Phe Leu 
            180                 185                 190         


Thr Gly Glu Ser Tyr Ala Gly Ile Tyr Ile Pro Thr Leu Ala Val Leu 
        195                 200                 205             


Val Met Gln Asp Pro Ser Met Asn Leu Gln Gly Leu Ala Val Gly Asn 
    210                 215                 220                 


Gly Leu Ser Ser Tyr Glu Gln Asn Asp Asn Ser Leu Val Tyr Phe Ala 
225                 230                 235                 240 


Tyr Tyr His Gly Leu Leu Gly Asn Arg Leu Trp Ser Ser Leu Gln Thr 
                245                 250                 255     


His Cys Cys Ser Gln Asn Lys Cys Asn Phe Tyr Asp Asn Lys Asp Leu 
            260                 265                 270         


Glu Cys Val Thr Asn Leu Gln Glu Val Ala Arg Ile Val Gly Asn Ser 
        275                 280                 285             


Gly Leu Asn Ile Tyr Asn Leu Tyr Ala Pro Cys Ala Gly Gly Val Pro 
    290                 295                 300                 


Ser His Phe Arg Tyr Glu Lys Asp Thr Val Val Val Gln Asp Leu Gly 
305                 310                 315                 320 


Asn Ile Phe Thr Arg Leu Pro Leu Lys Arg Met Trp His Gln Ala Leu 
                325                 330                 335     


Leu Arg Ser Gly Asp Lys Val Arg Met Asp Pro Pro Cys Thr Asn Thr 
            340                 345                 350         


Thr Ala Ala Ser Thr Tyr Leu Asn Asn Pro Tyr Val Arg Lys Ala Leu 
        355                 360                 365             


Asn Ile Pro Glu Gln Leu Pro Gln Trp Asp Met Cys Asn Phe Leu Val 
    370                 375                 380                 


Asn Leu Gln Tyr Arg Arg Leu Tyr Arg Ser Met Asn Ser Gln Tyr Leu 
385                 390                 395                 400 


Lys Leu Leu Ser Ser Gln Lys Tyr Gln Ile Leu Leu Tyr Asn Gly Asp 
                405                 410                 415     


Val Asp Met Ala Cys Asn Phe Met Gly Asp Glu Trp Phe Val Asp Ser 
            420                 425                 430         


Leu Asn Gln Lys Met Glu Val Gln Arg Arg Pro Trp Leu Val Lys Tyr 
        435                 440                 445             


Gly Asp Ser Gly Glu Gln Ile Ala Gly Phe Val Lys Glu Phe Ser His 
    450                 455                 460                 


Ile Ala Phe Leu Thr Ile Lys Gly Ala Gly His Met Val Pro Thr Asp 
465                 470                 475                 480 


Lys Pro Leu Ala Ala Phe Thr Met Phe Ser Arg Phe Leu Asn Lys Gln 
                485                 490                 495     


Pro Tyr 
        


<210>  213
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Gly Ala Gly Pro Ser Leu Leu Leu Ala Ala Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ser Gly Asp Gly Ala Val Arg Cys Asp Thr Pro Ala Asn Cys Thr Tyr 
            20                  25                  30          


Leu Asp Leu Leu Gly Thr Trp Val Phe Gln Val Gly Ser Ser Gly Ser 
        35                  40                  45              


Gln Arg Asp Val Asn Cys Ser Val Met Gly Pro Gln Glu Lys Lys Val 
    50                  55                  60                  


Val Val Tyr Leu Gln Lys Leu Asp Thr Ala Tyr Asp Asp Leu Gly Asn 
65                  70                  75                  80  


Ser Gly His Phe Thr Ile Ile Tyr Asn Gln Gly Phe Glu Ile Val Leu 
                85                  90                  95      


Asn Asp Tyr Lys Trp Phe Ala Phe Phe Lys Tyr Lys Glu Glu Gly Ser 
            100                 105                 110         


Lys Val Thr Thr Tyr Cys Asn Glu Thr Met Thr Gly Trp Val His Asp 
        115                 120                 125             


Val Leu Gly Arg Asn Trp Ala Cys Phe Thr Gly Lys Lys Val Gly Thr 
    130                 135                 140                 


Ala Ser Glu Asn Val Tyr Val Asn Ile Ala His Leu Lys Asn Ser Gln 
145                 150                 155                 160 


Glu Lys Tyr Ser Asn Arg Leu Tyr Lys Tyr Asp His Asn Phe Val Lys 
                165                 170                 175     


Ala Ile Asn Ala Ile Gln Lys Ser Trp Thr Ala Thr Thr Tyr Met Glu 
            180                 185                 190         


Tyr Glu Thr Leu Thr Leu Gly Asp Met Ile Arg Arg Ser Gly Gly His 
        195                 200                 205             


Ser Arg Lys Ile Pro Arg Pro Lys Pro Ala Pro Leu Thr Ala Glu Ile 
    210                 215                 220                 


Gln Gln Lys Ile Leu His Leu Pro Thr Ser Trp Asp Trp Arg Asn Val 
225                 230                 235                 240 


His Gly Ile Asn Phe Val Ser Pro Val Arg Asn Gln Ala Ser Cys Gly 
                245                 250                 255     


Ser Cys Tyr Ser Phe Ala Ser Met Gly Met Leu Glu Ala Arg Ile Arg 
            260                 265                 270         


Ile Leu Thr Asn Asn Ser Gln Thr Pro Ile Leu Ser Pro Gln Glu Val 
        275                 280                 285             


Val Ser Cys Ser Gln Tyr Ala Gln Gly Cys Glu Gly Gly Phe Pro Tyr 
    290                 295                 300                 


Leu Ile Ala Gly Lys Tyr Ala Gln Asp Phe Gly Leu Val Glu Glu Ala 
305                 310                 315                 320 


Cys Phe Pro Tyr Thr Gly Thr Asp Ser Pro Cys Lys Met Lys Glu Asp 
                325                 330                 335     


Cys Phe Arg Tyr Tyr Ser Ser Glu Tyr His Tyr Val Gly Gly Phe Tyr 
            340                 345                 350         


Gly Gly Cys Asn Glu Ala Leu Met Lys Leu Glu Leu Val His His Gly 
        355                 360                 365             


Pro Met Ala Val Ala Phe Glu Val Tyr Asp Asp Phe Leu His Tyr Lys 
    370                 375                 380                 


Lys Gly Ile Tyr His His Thr Gly Leu Arg Asp Pro Phe Asn Pro Phe 
385                 390                 395                 400 


Glu Leu Thr Asn His Ala Val Leu Leu Val Gly Tyr Gly Thr Asp Ser 
                405                 410                 415     


Ala Ser Gly Met Asp Tyr Trp Ile Val Lys Asn Ser Trp Gly Thr Gly 
            420                 425                 430         


Trp Gly Glu Asn Gly Tyr Phe Arg Ile Arg Arg Gly Thr Asp Glu Cys 
        435                 440                 445             


Ala Ile Glu Ser Ile Ala Val Ala Ala Thr Pro Ile Pro Lys Leu 
    450                 455                 460             


<210>  214
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala Ala Glu Leu Cys Val Asn Ser Leu Glu Lys 
            20                  25                  30          


Phe His Phe Lys Ser Trp Met Ser Lys His Arg Lys Thr Tyr Ser Thr 
        35                  40                  45              


Glu Glu Tyr His His Arg Leu Gln Thr Phe Ala Ser Asn Trp Arg Lys 
    50                  55                  60                  


Ile Asn Ala His Asn Asn Gly Asn His Thr Phe Lys Met Ala Leu Asn 
65                  70                  75                  80  


Gln Phe Ser Asp Met Ser Phe Ala Glu Ile Lys His Lys Tyr Leu Trp 
                85                  90                  95      


Ser Glu Pro Gln Asn Cys Ser Ala Thr Lys Ser Asn Tyr Leu Arg Gly 
            100                 105                 110         


Thr Gly Pro Tyr Pro Pro Ser Val Asp Trp Arg Lys Lys Gly Asn Phe 
        115                 120                 125             


Val Ser Pro Val Lys Asn Gln Gly Ala Cys Gly Ser Cys Trp Thr Phe 
    130                 135                 140                 


Ser Thr Thr Gly Ala Leu Glu Ser Ala Ile Ala Ile Ala Thr Gly Lys 
145                 150                 155                 160 


Met Leu Ser Leu Ala Glu Gln Gln Leu Val Asp Cys Ala Gln Asp Phe 
                165                 170                 175     


Asn Asn His Gly Cys Gln Gly Gly Leu Pro Ser Gln Ala Phe Glu Tyr 
            180                 185                 190         


Ile Leu Tyr Asn Lys Gly Ile Met Gly Glu Asp Thr Tyr Pro Tyr Gln 
        195                 200                 205             


Gly Lys Asp Gly Tyr Cys Lys Phe Gln Pro Gly Lys Ala Ile Gly Phe 
    210                 215                 220                 


Val Lys Asp Val Ala Asn Ile Thr Ile Tyr Asp Glu Glu Ala Met Val 
225                 230                 235                 240 


Glu Ala Val Ala Leu Tyr Asn Pro Val Ser Phe Ala Phe Glu Val Thr 
                245                 250                 255     


Gln Asp Phe Met Met Tyr Arg Thr Gly Ile Tyr Ser Ser Thr Ser Cys 
            260                 265                 270         


His Lys Thr Pro Asp Lys Val Asn His Ala Val Leu Ala Val Gly Tyr 
        275                 280                 285             


Gly Glu Lys Asn Gly Ile Pro Tyr Trp Ile Val Lys Asn Ser Trp Gly 
    290                 295                 300                 


Pro Gln Trp Gly Met Asn Gly Tyr Phe Leu Ile Glu Arg Gly Lys Asn 
305                 310                 315                 320 


Met Cys Gly Leu Ala Ala Cys Ala Ser Tyr Pro Ile Pro Leu Val 
                325                 330                 335 


<210>  215
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Gly Asn Trp Ala Val Asn Glu Gly Leu Ser Ile Phe Val Ile Leu 
1               5                   10                  15      


Val Trp Leu Gly Leu Asn Val Phe Leu Phe Val Trp Tyr Tyr Arg Val 
            20                  25                  30          


Tyr Asp Ile Pro Pro Lys Phe Phe Tyr Thr Arg Lys Leu Leu Gly Ser 
        35                  40                  45              


Ala Leu Ala Leu Ala Arg Ala Pro Ala Ala Cys Leu Asn Phe Asn Cys 
    50                  55                  60                  


Met Leu Ile Leu Leu Pro Val Cys Arg Asn Leu Leu Ser Phe Leu Arg 
65                  70                  75                  80  


Gly Ser Ser Ala Cys Cys Ser Thr Arg Val Arg Arg Gln Leu Asp Arg 
                85                  90                  95      


Asn Leu Thr Phe His Lys Met Val Ala Trp Met Ile Ala Leu His Ser 
            100                 105                 110         


Ala Ile His Thr Ile Ala His Leu Phe Asn Val Glu Trp Cys Val Asn 
        115                 120                 125             


Ala Arg Val Asn Asn Ser Asp Pro Tyr Ser Val Ala Leu Ser Glu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Asn Glu Ser Tyr Leu Asn Phe Ala Arg Lys Arg Ile 
145                 150                 155                 160 


Lys Asn Pro Glu Gly Gly Leu Tyr Leu Ala Val Thr Leu Leu Ala Gly 
                165                 170                 175     


Ile Thr Gly Val Val Ile Thr Leu Cys Leu Ile Leu Ile Ile Thr Ser 
            180                 185                 190         


Ser Thr Lys Thr Ile Arg Arg Ser Tyr Phe Glu Val Phe Trp Tyr Thr 
        195                 200                 205             


His His Leu Phe Val Ile Phe Phe Ile Gly Leu Ala Ile His Gly Ala 
    210                 215                 220                 


Glu Arg Ile Val Arg Gly Gln Thr Ala Glu Ser Leu Ala Val His Asn 
225                 230                 235                 240 


Ile Thr Val Cys Glu Gln Lys Ile Ser Glu Trp Gly Lys Ile Lys Glu 
                245                 250                 255     


Cys Pro Ile Pro Gln Phe Ala Gly Asn Pro Pro Met Thr Trp Lys Trp 
            260                 265                 270         


Ile Val Gly Pro Met Phe Leu Tyr Leu Cys Glu Arg Leu Val Arg Phe 
        275                 280                 285             


Trp Arg Ser Gln Gln Lys Val Val Ile Thr Lys Val Val Thr His Pro 
    290                 295                 300                 


Phe Lys Thr Ile Glu Leu Gln Met Lys Lys Lys Gly Phe Lys Met Glu 
305                 310                 315                 320 


Val Gly Gln Tyr Ile Phe Val Lys Cys Pro Lys Val Ser Lys Leu Glu 
                325                 330                 335     


Trp His Pro Phe Thr Leu Thr Ser Ala Pro Glu Glu Asp Phe Phe Ser 
            340                 345                 350         


Ile His Ile Arg Ile Val Gly Asp Trp Thr Glu Gly Leu Phe Asn Ala 
        355                 360                 365             


Cys Gly Cys Asp Lys Gln Glu Phe Gln Asp Ala Trp Lys Leu Pro Lys 
    370                 375                 380                 


Ile Ala Val Asp Gly Pro Phe Gly Thr Ala Ser Glu Asp Val Phe Ser 
385                 390                 395                 400 


Tyr Glu Val Val Met Leu Val Gly Ala Gly Ile Gly Val Thr Pro Phe 
                405                 410                 415     


Ala Ser Ile Leu Lys Ser Val Trp Tyr Lys Tyr Cys Asn Asn Ala Thr 
            420                 425                 430         


Asn Leu Lys Leu Lys Lys Ile Tyr Phe Tyr Trp Leu Cys Arg Asp Thr 
        435                 440                 445             


His Ala Phe Glu Trp Phe Ala Asp Leu Leu Gln Leu Leu Glu Ser Gln 
    450                 455                 460                 


Met Gln Glu Arg Asn Asn Ala Gly Phe Leu Ser Tyr Asn Ile Tyr Leu 
465                 470                 475                 480 


Thr Gly Trp Asp Glu Ser Gln Ala Asn His Phe Ala Val His His Asp 
                485                 490                 495     


Glu Glu Lys Asp Val Ile Thr Gly Leu Lys Gln Lys Thr Leu Tyr Gly 
            500                 505                 510         


Arg Pro Asn Trp Asp Asn Glu Phe Lys Thr Ile Ala Ser Gln His Pro 
        515                 520                 525             


Asn Thr Arg Ile Gly Val Phe Leu Cys Gly Pro Glu Ala Leu Ala Glu 
    530                 535                 540                 


Thr Leu Ser Lys Gln Ser Ile Ser Asn Ser Glu Ser Gly Pro Arg Gly 
545                 550                 555                 560 


Val His Phe Ile Phe Asn Lys Glu Asn Phe 
                565                 570 


<210>  216
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Leu Asp Phe Ala Ile Phe Ala Val Thr Phe Leu Leu Ala Leu Val 
1               5                   10                  15      


Gly Ala Val Leu Tyr Leu Tyr Pro Ala Ser Arg Gln Ala Ala Gly Ile 
            20                  25                  30          


Pro Gly Ile Thr Pro Thr Glu Glu Lys Asp Gly Asn Leu Pro Asp Ile 
        35                  40                  45              


Val Asn Ser Gly Ser Leu His Glu Phe Leu Val Asn Leu His Glu Arg 
    50                  55                  60                  


Tyr Gly Pro Val Val Ser Phe Trp Phe Gly Arg Arg Leu Val Val Ser 
65                  70                  75                  80  


Leu Gly Thr Val Asp Val Leu Lys Gln His Ile Asn Pro Asn Lys Thr 
                85                  90                  95      


Ser Asp Pro Phe Glu Thr Met Leu Lys Ser Leu Leu Arg Tyr Gln Ser 
            100                 105                 110         


Gly Gly Gly Ser Val Ser Glu Asn His Met Arg Lys Lys Leu Tyr Glu 
        115                 120                 125             


Asn Gly Val Thr Asp Ser Leu Lys Ser Asn Phe Ala Leu Leu Leu Lys 
    130                 135                 140                 


Leu Ser Glu Glu Leu Leu Asp Lys Trp Leu Ser Tyr Pro Glu Thr Gln 
145                 150                 155                 160 


His Val Pro Leu Ser Gln His Met Leu Gly Phe Ala Met Lys Ser Val 
                165                 170                 175     


Thr Gln Met Val Met Gly Ser Thr Phe Glu Asp Asp Gln Glu Val Ile 
            180                 185                 190         


Arg Phe Gln Lys Asn His Gly Thr Val Trp Ser Glu Ile Gly Lys Gly 
        195                 200                 205             


Phe Leu Asp Gly Ser Leu Asp Lys Asn Met Thr Arg Lys Lys Gln Tyr 
    210                 215                 220                 


Glu Asp Ala Leu Met Gln Leu Glu Ser Val Leu Arg Asn Ile Ile Lys 
225                 230                 235                 240 


Glu Arg Lys Gly Arg Asn Phe Ser Gln His Ile Phe Ile Asp Ser Leu 
                245                 250                 255     


Val Gln Gly Asn Leu Asn Asp Gln Gln Ile Leu Glu Asp Ser Met Ile 
            260                 265                 270         


Phe Ser Leu Ala Ser Cys Ile Ile Thr Ala Lys Leu Cys Thr Trp Ala 
        275                 280                 285             


Ile Cys Phe Leu Thr Thr Ser Glu Glu Val Gln Lys Lys Leu Tyr Glu 
    290                 295                 300                 


Glu Ile Asn Gln Val Phe Gly Asn Gly Pro Val Thr Pro Glu Lys Ile 
305                 310                 315                 320 


Glu Gln Leu Arg Tyr Cys Gln His Val Leu Cys Glu Thr Val Arg Thr 
                325                 330                 335     


Ala Lys Leu Thr Pro Val Ser Ala Gln Leu Gln Asp Ile Glu Gly Lys 
            340                 345                 350         


Ile Asp Arg Phe Ile Ile Pro Arg Glu Thr Leu Val Leu Tyr Ala Leu 
        355                 360                 365             


Gly Val Val Leu Gln Asp Pro Asn Thr Trp Pro Ser Pro His Lys Phe 
    370                 375                 380                 


Asp Pro Asp Arg Phe Asp Asp Glu Leu Val Met Lys Thr Phe Ser Ser 
385                 390                 395                 400 


Leu Gly Phe Ser Gly Thr Gln Glu Cys Pro Glu Leu Arg Phe Ala Tyr 
                405                 410                 415     


Met Val Thr Thr Val Leu Leu Ser Val Leu Val Lys Arg Leu His Leu 
            420                 425                 430         


Leu Ser Val Glu Gly Gln Val Ile Glu Thr Lys Tyr Glu Leu Val Thr 
        435                 440                 445             


Ser Ser Arg Glu Glu Ala Trp Ile Thr Val Ser Lys Arg Tyr 
    450                 455                 460         


<210>  217
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  217

Met Ser Ala His Asn Arg Gly Thr Glu Leu Asp Leu Ser Trp Ile Ser 
1               5                   10                  15      


Lys Ile Gln Val Asn His Pro Ala Val Leu Arg Arg Ala Glu Gln Ile 
            20                  25                  30          


Gln Ala Arg Arg Thr Val Lys Lys Glu Trp Gln Ala Ala Trp Leu Leu 
        35                  40                  45              


Lys Ala Val Thr Phe Ile Asp Leu Thr Thr Leu Ser Gly Asp Asp Thr 
    50                  55                  60                  


Ser Ser Asn Ile Gln Arg Leu Cys Tyr Lys Ala Lys Tyr Pro Ile Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Lys Ala Leu Asn Met His Asp Lys Gly Ile Thr Thr 
                85                  90                  95      


Ala Ala Val Cys Val Tyr Pro Ala Arg Val Cys Asp Ala Val Lys Ala 
            100                 105                 110         


Leu Lys Ala Ala Gly Cys Asn Ile Pro Val Ala Ser Val Ala Ala Gly 
        115                 120                 125             


Phe Pro Ala Gly Gln Thr His Leu Lys Thr Arg Leu Glu Glu Ile Arg 
    130                 135                 140                 


Leu Ala Val Glu Asp Gly Ala Thr Glu Ile Asp Val Val Ile Asn Arg 
145                 150                 155                 160 


Ser Leu Val Leu Thr Gly Gln Trp Glu Ala Leu Tyr Asp Glu Ile Arg 
                165                 170                 175     


Gln Phe Arg Lys Ala Cys Gly Glu Ala His Leu Lys Thr Ile Leu Ala 
            180                 185                 190         


Thr Gly Glu Leu Gly Thr Leu Thr Asn Val Tyr Lys Ala Ser Met Ile 
        195                 200                 205             


Ala Met Met Ala Gly Ser Asp Phe Ile Lys Thr Ser Thr Gly Lys Glu 
    210                 215                 220                 


Thr Val Asn Ala Thr Phe Pro Val Ala Ile Val Met Leu Arg Ala Ile 
225                 230                 235                 240 


Arg Asp Phe Phe Trp Lys Thr Gly Asn Lys Ile Gly Phe Lys Pro Ala 
                245                 250                 255     


Gly Gly Ile Arg Ser Ala Lys Asp Ser Leu Ala Trp Leu Ser Leu Val 
            260                 265                 270         


Lys Glu Glu Leu Gly Asp Glu Trp Leu Lys Pro Glu Leu Phe Arg Ile 
        275                 280                 285             


Gly Ala Ser Thr Leu Leu Ser Asp Ile Glu Arg Gln Ile Tyr His His 
    290                 295                 300                 


Val Thr Gly Arg Tyr Ala Ala Tyr His Asp Leu Pro Met Ser 
305                 310                 315             


<210>  218
<211>  1041
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Thr Pro Ala Gly Leu Glu Arg Trp Val Gln Asp Glu Leu His 
1               5                   10                  15      


Ser Val Leu Gly Leu Ser Glu Arg His Val Ala Gln Phe Leu Ile Gly 
            20                  25                  30          


Thr Ala Gln Arg Cys Thr Ser Ala Glu Glu Phe Val Gln Arg Leu Arg 
        35                  40                  45              


Asp Thr Asp Thr Leu Asp Leu Ser Gly Pro Ala Arg Asp Phe Ala Leu 
    50                  55                  60                  


Arg Leu Trp Asn Lys Val Pro Arg Lys Ala Val Val Glu Lys Pro Ala 
65                  70                  75                  80  


Arg Ala Ala Glu Arg Glu Ala Arg Ala Leu Leu Glu Lys Asn Arg Ser 
                85                  90                  95      


Tyr Arg Leu Leu Glu Asp Ser Glu Glu Ser Ser Glu Glu Thr Val Ser 
            100                 105                 110         


Arg Ala Gly Ser Ser Leu Gln Lys Lys Arg Lys Lys Arg Lys His Leu 
        115                 120                 125             


Arg Lys Lys Arg Glu Glu Glu Glu Glu Glu Glu Ala Ser Glu Lys Gly 
    130                 135                 140                 


Lys Lys Lys Thr Gly Gly Ser Lys Gln Gln Thr Glu Lys Pro Glu Ser 
145                 150                 155                 160 


Glu Asp Glu Trp Glu Arg Thr Glu Arg Glu Arg Leu Gln Asp Leu Glu 
                165                 170                 175     


Glu Arg Asp Ala Phe Ala Glu Arg Val Arg Gln Arg Asp Lys Asp Arg 
            180                 185                 190         


Thr Arg Asn Val Leu Glu Arg Ser Asp Lys Lys Ala Tyr Glu Glu Ala 
        195                 200                 205             


Gln Lys Arg Leu Lys Met Ala Glu Glu Asp Arg Lys Ala Met Val Pro 
    210                 215                 220                 


Glu Leu Arg Lys Lys Ser Arg Arg Glu Tyr Leu Ala Lys Arg Glu Arg 
225                 230                 235                 240 


Glu Lys Leu Glu Asp Leu Glu Ala Glu Leu Ala Asp Glu Glu Phe Leu 
                245                 250                 255     


Phe Gly Asp Val Glu Leu Ser Arg His Glu Arg Gln Glu Leu Lys Tyr 
            260                 265                 270         


Lys Arg Arg Val Arg Asp Leu Ala Arg Glu Tyr Arg Ala Ala Gly Glu 
        275                 280                 285             


Gln Glu Lys Leu Glu Ala Thr Asn Arg Tyr His Met Pro Lys Glu Thr 
    290                 295                 300                 


Arg Gly Gln Pro Ala Arg Ala Val Asp Leu Val Glu Glu Glu Ser Gly 
305                 310                 315                 320 


Ala Pro Gly Glu Glu Gln Arg Arg Trp Glu Glu Ala Arg Leu Gly Ala 
                325                 330                 335     


Ala Ser Leu Lys Phe Gly Ala Arg Asp Ala Ala Ser Gln Glu Pro Lys 
            340                 345                 350         


Tyr Gln Leu Val Leu Glu Glu Glu Glu Thr Ile Glu Phe Val Arg Ala 
        355                 360                 365             


Thr Gln Leu Gln Gly Asp Glu Glu Pro Ser Ala Pro Pro Thr Ser Thr 
    370                 375                 380                 


Gln Ala Gln Gln Lys Glu Ser Ile Gln Ala Val Arg Arg Ser Leu Pro 
385                 390                 395                 400 


Val Phe Pro Phe Arg Glu Glu Leu Leu Ala Ala Ile Ala Asn His Gln 
                405                 410                 415     


Val Leu Ile Ile Glu Gly Glu Thr Gly Ser Gly Lys Thr Thr Gln Ile 
            420                 425                 430         


Pro Gln Tyr Leu Phe Glu Glu Gly Tyr Thr Asn Lys Gly Met Lys Ile 
        435                 440                 445             


Ala Cys Thr Gln Pro Arg Arg Val Ala Ala Met Ser Val Ala Ala Arg 
    450                 455                 460                 


Val Ala Arg Glu Met Gly Val Lys Leu Gly Asn Glu Val Gly Tyr Ser 
465                 470                 475                 480 


Ile Arg Phe Glu Asp Cys Thr Ser Glu Arg Thr Val Leu Arg Tyr Met 
                485                 490                 495     


Thr Asp Gly Met Leu Leu Arg Glu Phe Leu Ser Glu Pro Asp Leu Ala 
            500                 505                 510         


Ser Tyr Ser Val Val Met Val Asp Glu Ala His Glu Arg Thr Leu His 
        515                 520                 525             


Thr Asp Ile Leu Phe Gly Leu Ile Lys Asp Val Ala Arg Phe Arg Pro 
    530                 535                 540                 


Glu Leu Lys Val Leu Val Ala Ser Ala Thr Met Asp Thr Ala Arg Phe 
545                 550                 555                 560 


Ser Thr Phe Phe Asp Asp Ala Pro Val Phe Arg Ile Pro Gly Arg Arg 
                565                 570                 575     


Phe Pro Val Asp Ile Phe Tyr Thr Lys Ala Pro Glu Ala Asp Tyr Leu 
            580                 585                 590         


Glu Ala Cys Val Val Ser Val Leu Gln Ile His Val Thr Gln Pro Pro 
        595                 600                 605             


Gly Asp Ile Leu Val Phe Leu Thr Gly Gln Glu Glu Ile Glu Ala Ala 
    610                 615                 620                 


Cys Glu Met Leu Gln Asp Arg Cys Arg Arg Leu Gly Ser Lys Ile Arg 
625                 630                 635                 640 


Glu Leu Leu Val Leu Pro Ile Tyr Ala Asn Leu Pro Ser Asp Met Gln 
                645                 650                 655     


Ala Arg Ile Phe Gln Pro Thr Pro Pro Gly Ala Arg Lys Val Val Val 
            660                 665                 670         


Ala Thr Asn Ile Ala Glu Thr Ser Leu Thr Ile Glu Gly Ile Ile Tyr 
        675                 680                 685             


Val Leu Asp Pro Gly Phe Cys Lys Gln Lys Ser Tyr Asn Pro Arg Thr 
    690                 695                 700                 


Gly Met Glu Ser Leu Thr Val Thr Pro Cys Ser Lys Ala Ser Ala Asn 
705                 710                 715                 720 


Gln Arg Ala Gly Arg Ala Gly Arg Val Ala Ala Gly Lys Cys Phe Arg 
                725                 730                 735     


Leu Tyr Thr Ala Trp Ala Tyr Gln His Glu Leu Glu Glu Thr Thr Val 
            740                 745                 750         


Pro Glu Ile Gln Arg Thr Ser Leu Gly Asn Val Val Leu Leu Leu Lys 
        755                 760                 765             


Ser Leu Gly Ile His Asp Leu Met His Phe Asp Phe Leu Asp Pro Pro 
    770                 775                 780                 


Pro Tyr Glu Thr Leu Leu Leu Ala Leu Glu Gln Leu Tyr Ala Leu Gly 
785                 790                 795                 800 


Ala Leu Asn His Leu Gly Glu Leu Thr Thr Ser Gly Arg Lys Met Ala 
                805                 810                 815     


Glu Leu Pro Val Asp Pro Met Leu Ser Lys Met Ile Leu Ala Ser Glu 
            820                 825                 830         


Lys Tyr Ser Cys Ser Glu Glu Ile Leu Thr Val Ala Ala Met Leu Ser 
        835                 840                 845             


Val Asn Asn Ser Ile Phe Tyr Arg Pro Lys Asp Lys Val Val His Ala 
    850                 855                 860                 


Asp Asn Ala Arg Val Asn Phe Phe Leu Pro Gly Gly Asp His Leu Val 
865                 870                 875                 880 


Leu Leu Asn Val Tyr Thr Gln Trp Ala Glu Ser Gly Tyr Ser Ser Gln 
                885                 890                 895     


Trp Cys Tyr Glu Asn Phe Val Gln Phe Arg Ser Met Arg Arg Ala Arg 
            900                 905                 910         


Asp Val Arg Glu Gln Leu Glu Gly Leu Leu Glu Arg Val Glu Val Gly 
        915                 920                 925             


Leu Ser Ser Cys Gln Gly Asp Tyr Ile Arg Val Arg Lys Ala Ile Thr 
    930                 935                 940                 


Ala Gly Tyr Phe Tyr His Thr Ala Arg Leu Thr Arg Ser Gly Tyr Arg 
945                 950                 955                 960 


Thr Val Lys Gln Gln Gln Thr Val Phe Ile His Pro Asn Ser Ser Leu 
                965                 970                 975     


Phe Glu Gln Gln Pro Arg Trp Leu Leu Tyr His Glu Leu Val Leu Thr 
            980                 985                 990         


Thr Lys Glu Phe Met Arg Gln Val  Leu Glu Ile Glu Ser  Ser Trp Leu 
        995                 1000                 1005             


Leu Glu  Val Ala Pro His Tyr  Tyr Lys Ala Lys Glu  Leu Glu Asp 
    1010                 1015                 1020             


Pro His  Ala Lys Lys Met Pro  Lys Lys Ile Gly Lys  Thr Arg Glu 
    1025                 1030                 1035             


Glu Leu  Gly 
    1040     


<210>  219
<211>  1101
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Glu Gln Pro Gly Ala Ala Ala Ser Gly Ala Gly Gly Gly Ser Glu 
1               5                   10                  15      


Glu Pro Gly Gly Gly Arg Ser Asn Lys Arg Ser Ala Gly Asn Arg Ala 
            20                  25                  30          


Ala Asn Glu Glu Glu Thr Lys Asn Lys Pro Lys Leu Asn Ile Gln Ile 
        35                  40                  45              


Lys Thr Leu Ala Asp Asp Val Arg Asp Arg Ile Thr Ser Phe Arg Lys 
    50                  55                  60                  


Ser Thr Val Lys Lys Glu Lys Pro Leu Ile Gln His Pro Ile Asp Ser 
65                  70                  75                  80  


Gln Val Ala Met Ser Glu Phe Pro Ala Ala Gln Pro Leu Tyr Asp Glu 
                85                  90                  95      


Arg Ser Leu Asn Leu Ser Glu Lys Glu Val Leu Asp Leu Phe Glu Lys 
            100                 105                 110         


Met Met Glu Asp Met Asn Leu Asn Glu Glu Lys Lys Ala Pro Leu Arg 
        115                 120                 125             


Asn Lys Asp Phe Thr Thr Lys Arg Glu Met Val Val Gln Tyr Ile Ser 
    130                 135                 140                 


Ala Thr Ala Lys Ser Gly Gly Leu Lys Asn Ser Lys His Glu Cys Thr 
145                 150                 155                 160 


Leu Ser Ser Gln Glu Tyr Val His Glu Leu Arg Ser Gly Ile Ser Asp 
                165                 170                 175     


Glu Lys Leu Leu Asn Cys Leu Glu Ser Leu Arg Val Ser Leu Thr Ser 
            180                 185                 190         


Asn Pro Val Ser Trp Val Asn Asn Phe Gly His Glu Gly Leu Gly Leu 
        195                 200                 205             


Leu Leu Asp Glu Leu Glu Lys Leu Leu Asp Lys Lys Gln Gln Glu Asn 
    210                 215                 220                 


Ile Asp Lys Lys Asn Gln Tyr Lys Leu Ile Gln Cys Leu Lys Ala Phe 
225                 230                 235                 240 


Met Asn Asn Lys Phe Gly Leu Gln Arg Ile Leu Gly Asp Glu Arg Ser 
                245                 250                 255     


Leu Leu Leu Leu Ala Arg Ala Ile Asp Pro Lys Gln Pro Asn Met Met 
            260                 265                 270         


Thr Glu Ile Val Lys Ile Leu Ser Ala Ile Cys Ile Val Gly Glu Glu 
        275                 280                 285             


Asn Ile Leu Asp Lys Leu Leu Gly Ala Ile Thr Thr Ala Ala Glu Arg 
    290                 295                 300                 


Asn Asn Arg Glu Arg Phe Ser Pro Ile Val Glu Gly Leu Glu Asn Gln 
305                 310                 315                 320 


Glu Ala Leu Gln Leu Gln Val Ala Cys Met Gln Phe Ile Asn Ala Leu 
                325                 330                 335     


Val Thr Ser Pro Tyr Glu Leu Asp Phe Arg Ile His Leu Arg Asn Glu 
            340                 345                 350         


Phe Leu Arg Ser Gly Leu Lys Thr Met Leu Pro Asp Leu Lys Glu Lys 
        355                 360                 365             


Glu Asn Asp Glu Leu Asp Ile Gln Leu Lys Val Phe Asp Glu Asn Lys 
    370                 375                 380                 


Glu Asp Asp Leu Thr Glu Leu Ser His Arg Leu Asn Asp Ile Arg Ala 
385                 390                 395                 400 


Glu Met Asp Asp Met Asn Glu Val Tyr His Leu Leu Tyr Asn Met Leu 
                405                 410                 415     


Lys Asp Thr Ala Ala Glu Asn Tyr Phe Leu Ser Ile Leu Gln His Phe 
            420                 425                 430         


Leu Leu Ile Arg Asn Asp Tyr Tyr Ile Arg Pro Gln Tyr Tyr Lys Ile 
        435                 440                 445             


Ile Glu Glu Cys Val Ser Gln Ile Val Leu His Cys Ser Gly Met Asp 
    450                 455                 460                 


Pro Asp Phe Lys Tyr Arg Gln Arg Leu Asp Ile Asp Leu Thr His Leu 
465                 470                 475                 480 


Ile Asp Ser Cys Val Asn Lys Ala Lys Val Glu Glu Ser Glu Gln Lys 
                485                 490                 495     


Ala Ala Glu Phe Ser Lys Lys Phe Asp Glu Glu Phe Thr Ala Arg Gln 
            500                 505                 510         


Glu Ala Gln Ala Glu Leu Gln Lys Arg Asp Glu Lys Ile Lys Glu Leu 
        515                 520                 525             


Glu Ala Glu Ile Gln Gln Leu Arg Thr Gln Ala Gln Val Leu Ser Ser 
    530                 535                 540                 


Ser Ser Gly Ile Pro Gly Pro Pro Ala Ala Pro Pro Leu Pro Gly Val 
545                 550                 555                 560 


Gly Pro Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Gly Gly Ala Pro 
                565                 570                 575     


Leu Pro Pro Pro Pro Pro Pro Leu Pro Gly Met Met Gly Ile Pro Pro 
            580                 585                 590         


Pro Pro Pro Pro Pro Leu Leu Phe Gly Gly Pro Pro Pro Pro Pro Pro 
        595                 600                 605             


Leu Gly Gly Val Pro Pro Pro Pro Gly Ile Ser Leu Asn Leu Pro Tyr 
    610                 615                 620                 


Gly Met Lys Gln Lys Lys Met Tyr Lys Pro Glu Val Ser Met Lys Arg 
625                 630                 635                 640 


Ile Asn Trp Ser Lys Ile Glu Pro Thr Glu Leu Ser Glu Asn Cys Phe 
                645                 650                 655     


Trp Leu Arg Val Lys Glu Asp Lys Phe Glu Asn Pro Asp Leu Phe Ala 
            660                 665                 670         


Lys Leu Ala Leu Asn Phe Ala Thr Gln Ile Lys Val Gln Lys Asn Ala 
        675                 680                 685             


Glu Ala Leu Glu Glu Lys Lys Thr Gly Pro Thr Lys Lys Lys Val Lys 
    690                 695                 700                 


Glu Leu Arg Ile Leu Asp Pro Lys Thr Ala Gln Asn Leu Ser Ile Phe 
705                 710                 715                 720 


Leu Gly Ser Tyr Arg Met Pro Tyr Glu Asp Ile Arg Asn Val Ile Leu 
                725                 730                 735     


Glu Val Asn Glu Asp Met Leu Ser Glu Ala Leu Ile Gln Asn Leu Val 
            740                 745                 750         


Lys His Leu Pro Glu Gln Lys Ile Leu Asn Glu Leu Ala Glu Leu Lys 
        755                 760                 765             


Asn Glu Tyr Asp Asp Leu Cys Glu Pro Glu Gln Phe Gly Val Val Met 
    770                 775                 780                 


Ser Ser Val Lys Met Leu Gln Pro Arg Leu Ser Ser Ile Leu Phe Lys 
785                 790                 795                 800 


Leu Thr Phe Glu Glu His Ile Asn Asn Ile Lys Pro Ser Ile Ile Ala 
                805                 810                 815     


Val Thr Leu Ala Cys Glu Glu Leu Lys Lys Ser Glu Ser Phe Asn Arg 
            820                 825                 830         


Leu Leu Glu Leu Val Leu Leu Val Gly Asn Tyr Met Asn Ser Gly Ser 
        835                 840                 845             


Arg Asn Ala Gln Ser Leu Gly Phe Lys Ile Asn Phe Leu Cys Lys Ile 
    850                 855                 860                 


Arg Asp Thr Lys Ser Ala Asp Gln Lys Thr Thr Leu Leu His Phe Ile 
865                 870                 875                 880 


Ala Asp Ile Cys Glu Glu Lys Tyr Arg Asp Ile Leu Lys Phe Pro Glu 
                885                 890                 895     


Glu Leu Glu His Val Glu Ser Ala Ser Lys Val Ser Ala Gln Ile Leu 
            900                 905                 910         


Lys Ser Asn Leu Ala Ser Met Glu Gln Gln Ile Val His Leu Glu Arg 
        915                 920                 925             


Asp Ile Lys Lys Phe Pro Gln Ala Glu Asn Gln His Asp Lys Phe Val 
    930                 935                 940                 


Glu Lys Met Thr Ser Phe Thr Lys Thr Ala Arg Glu Gln Tyr Glu Lys 
945                 950                 955                 960 


Leu Ser Thr Met His Asn Asn Met Met Lys Leu Tyr Glu Asn Leu Gly 
                965                 970                 975     


Glu Tyr Phe Ile Phe Asp Ser Lys Thr Val Ser Ile Glu Glu Phe Phe 
            980                 985                 990         


Gly Asp Leu Asn Asn Phe Arg Thr  Leu Phe Leu Glu Ala  Val Arg Glu 
        995                 1000                 1005             


Asn Asn  Lys Arg Arg Glu Met  Glu Glu Lys Thr Arg  Arg Ala Lys 
    1010                 1015                 1020             


Leu Ala  Lys Glu Lys Ala Glu  Gln Glu Lys Leu Glu  Arg Gln Lys 
    1025                 1030                 1035             


Lys Lys  Lys Gln Leu Ile Asp  Ile Asn Lys Glu Gly  Asp Glu Thr 
    1040                 1045                 1050             


Gly Val  Met Asp Asn Leu Leu  Glu Ala Leu Gln Ser  Gly Ala Ala 
    1055                 1060                 1065             


Phe Arg  Asp Arg Arg Lys Arg  Ile Pro Arg Asn Pro  Asp Asn Arg 
    1070                 1075                 1080             


Arg Val  Pro Leu Glu Arg Ser  Arg Ser Arg His Asn  Gly Ala Ile 
    1085                 1090                 1095             


Ser Ser  Lys 
    1100     


<210>  220
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Leu Ser Arg Ser Arg Cys Val Ser Arg Ala Phe Ser Arg Ser Leu 
1               5                   10                  15      


Ser Ala Phe Gln Lys Gly Asn Cys Pro Leu Gly Arg Arg Ser Leu Pro 
            20                  25                  30          


Gly Val Ser Leu Cys Gln Gly Pro Gly Tyr Pro Asn Ser Arg Lys Val 
        35                  40                  45              


Val Ile Asn Asn Ser Val Phe Ser Val Arg Phe Phe Arg Thr Thr Ala 
    50                  55                  60                  


Val Cys Lys Asp Asp Leu Val Thr Val Lys Thr Pro Ala Phe Ala Glu 
65                  70                  75                  80  


Ser Val Thr Glu Gly Asp Val Arg Trp Glu Lys Ala Val Gly Asp Thr 
                85                  90                  95      


Val Ala Glu Asp Glu Val Val Cys Glu Ile Glu Thr Asp Lys Thr Ser 
            100                 105                 110         


Val Gln Val Pro Ser Pro Ala Asn Gly Val Ile Glu Ala Leu Leu Val 
        115                 120                 125             


Pro Asp Gly Gly Lys Val Glu Gly Gly Thr Pro Leu Phe Thr Leu Arg 
    130                 135                 140                 


Lys Thr Gly Ala Ala Pro Ala Lys Ala Lys Pro Ala Glu Ala Pro Ala 
145                 150                 155                 160 


Ala Ala Ala Pro Lys Ala Glu Pro Thr Ala Ala Ala Val Pro Pro Pro 
                165                 170                 175     


Ala Ala Pro Ile Pro Thr Gln Met Pro Pro Val Pro Ser Pro Ser Gln 
            180                 185                 190         


Pro Pro Ser Gly Lys Pro Val Ser Ala Val Lys Pro Thr Val Ala Pro 
        195                 200                 205             


Pro Leu Ala Glu Pro Gly Ala Gly Lys Gly Leu Arg Ser Glu His Arg 
    210                 215                 220                 


Glu Lys Met Asn Arg Met Arg Gln Arg Ile Ala Gln Arg Leu Lys Glu 
225                 230                 235                 240 


Ala Gln Asn Thr Cys Ala Met Leu Thr Thr Phe Asn Glu Ile Asp Met 
                245                 250                 255     


Ser Asn Ile Gln Glu Met Arg Ala Arg His Lys Glu Ala Phe Leu Lys 
            260                 265                 270         


Lys His Asn Leu Lys Leu Gly Phe Met Ser Ala Phe Val Lys Ala Ser 
        275                 280                 285             


Ala Phe Ala Leu Gln Glu Gln Pro Val Val Asn Ala Val Ile Asp Asp 
    290                 295                 300                 


Thr Thr Lys Glu Val Val Tyr Arg Asp Tyr Ile Asp Ile Ser Val Ala 
305                 310                 315                 320 


Val Ala Thr Pro Arg Gly Leu Val Val Pro Val Ile Arg Asn Val Glu 
                325                 330                 335     


Ala Met Asn Phe Ala Asp Ile Glu Arg Thr Ile Thr Glu Leu Gly Glu 
            340                 345                 350         


Lys Ala Arg Lys Asn Glu Leu Ala Ile Glu Asp Met Asp Gly Gly Thr 
        355                 360                 365             


Phe Thr Ile Ser Asn Gly Gly Val Phe Gly Ser Leu Phe Gly Thr Pro 
    370                 375                 380                 


Ile Ile Asn Pro Pro Gln Ser Ala Ile Leu Gly Met His Gly Ile Phe 
385                 390                 395                 400 


Asp Arg Pro Val Ala Ile Gly Gly Lys Val Glu Val Arg Pro Met Met 
                405                 410                 415     


Tyr Val Ala Leu Thr Tyr Asp His Arg Leu Ile Asp Gly Arg Glu Ala 
            420                 425                 430         


Val Thr Phe Leu Arg Lys Ile Lys Ala Ala Val Glu Asp Pro Arg Val 
        435                 440                 445             


Leu Leu Leu Asp Leu 
    450             


<210>  221
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  221

Met Ser Gly Gly Ser Ala Asp Tyr Asn Arg Glu His Gly Gly Pro Glu 
1               5                   10                  15      


Gly Met Asp Pro Asp Gly Val Ile Glu Ser Asn Trp Asn Glu Ile Val 
            20                  25                  30          


Asp Asn Phe Asp Asp Met Asn Leu Lys Glu Ser Leu Leu Arg Gly Ile 
        35                  40                  45              


Tyr Ala Tyr Gly Phe Glu Lys Pro Ser Ala Ile Gln Gln Arg Ala Ile 
    50                  55                  60                  


Ile Pro Cys Ile Lys Gly Tyr Asp Val Ile Ala Gln Ala Gln Ser Gly 
65                  70                  75                  80  


Thr Gly Lys Thr Ala Thr Phe Ala Ile Ser Ile Leu Gln Gln Leu Glu 
                85                  90                  95      


Ile Glu Phe Lys Glu Thr Gln Ala Leu Val Leu Ala Pro Thr Arg Glu 
            100                 105                 110         


Leu Ala Gln Gln Ile Gln Lys Val Ile Leu Ala Leu Gly Asp Tyr Met 
        115                 120                 125             


Gly Ala Thr Cys His Ala Cys Ile Gly Gly Thr Asn Val Arg Asn Glu 
    130                 135                 140                 


Met Gln Lys Leu Gln Ala Glu Ala Pro His Ile Val Val Gly Thr Pro 
145                 150                 155                 160 


Gly Arg Val Phe Asp Met Leu Asn Arg Arg Tyr Leu Ser Pro Lys Trp 
                165                 170                 175     


Ile Lys Met Phe Val Leu Asp Glu Ala Asp Glu Met Leu Ser Arg Gly 
            180                 185                 190         


Phe Lys Asp Gln Ile Tyr Glu Ile Phe Gln Lys Leu Asn Thr Ser Ile 
        195                 200                 205             


Gln Val Val Leu Leu Ser Ala Thr Met Pro Thr Asp Val Leu Glu Val 
    210                 215                 220                 


Thr Lys Lys Phe Met Arg Asp Pro Ile Arg Ile Leu Val Lys Lys Glu 
225                 230                 235                 240 


Glu Leu Thr Leu Glu Gly Ile Lys Gln Phe Tyr Ile Asn Val Glu Arg 
                245                 250                 255     


Glu Glu Trp Lys Leu Asp Thr Leu Cys Asp Leu Tyr Glu Thr Leu Thr 
            260                 265                 270         


Ile Thr Gln Ala Val Ile Phe Leu Asn Thr Arg Arg Lys Val Asp Trp 
        275                 280                 285             


Leu Thr Glu Lys Met His Ala Arg Asp Phe Thr Val Ser Ala Leu His 
    290                 295                 300                 


Gly Asp Met Asp Gln Lys Glu Arg Asp Val Ile Met Arg Glu Phe Arg 
305                 310                 315                 320 


Ser Gly Ser Ser Arg Val Leu Ile Thr Thr Asp Leu Leu Ala Arg Gly 
                325                 330                 335     


Ile Asp Val Gln Gln Val Ser Leu Val Ile Asn Tyr Asp Leu Pro Thr 
            340                 345                 350         


Asn Arg Glu Asn Tyr Ile His Arg Ile Gly Arg Gly Gly Arg Phe Gly 
        355                 360                 365             


Arg Lys Gly Val Ala Ile Asn Phe Val Thr Glu Glu Asp Lys Arg Ile 
    370                 375                 380                 


Leu Arg Asp Ile Glu Thr Phe Tyr Asn Thr Thr Val Glu Glu Met Pro 
385                 390                 395                 400 


Met Asn Val Ala Asp Leu Ile 
                405         


<210>  222
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Asn Asn Lys Phe Asp Ala Leu Lys Asp Asp Asp Ser Gly Asp His 
1               5                   10                  15      


Asp Gln Asn Glu Glu Asn Ser Thr Gln Lys Asp Gly Glu Lys Glu Lys 
            20                  25                  30          


Thr Glu Arg Asp Lys Asn Gln Ser Ser Ser Lys Arg Lys Ala Val Val 
        35                  40                  45              


Pro Gly Pro Ala Glu His Pro Leu Gln Tyr Asn Tyr Thr Phe Trp Tyr 
    50                  55                  60                  


Ser Arg Arg Thr Pro Gly Arg Pro Thr Ser Ser Gln Ser Tyr Glu Gln 
65                  70                  75                  80  


Asn Ile Lys Gln Ile Gly Thr Phe Ala Ser Val Glu Gln Phe Trp Arg 
                85                  90                  95      


Phe Tyr Ser His Met Val Arg Pro Gly Asp Leu Thr Gly His Ser Asp 
            100                 105                 110         


Phe His Leu Phe Lys Glu Gly Ile Lys Pro Met Trp Glu Asp Asp Ala 
        115                 120                 125             


Asn Lys Asn Gly Gly Lys Trp Ile Ile Arg Leu Arg Lys Gly Leu Ala 
    130                 135                 140                 


Ser Arg Cys Trp Glu Asn Leu Ile Leu Ala Met Leu Gly Glu Gln Phe 
145                 150                 155                 160 


Met Val Gly Glu Glu Ile Cys Gly Ala Val Val Ser Val Arg Phe Gln 
                165                 170                 175     


Glu Asp Ile Ile Ser Ile Trp Asn Lys Thr Ala Ser Asp Gln Ala Thr 
            180                 185                 190         


Thr Ala Arg Ile Arg Asp Thr Leu Arg Arg Val Leu Asn Leu Pro Pro 
        195                 200                 205             


Asn Thr Ile Met Glu Tyr Lys Thr His Thr Asp Ser Ile Lys Met Pro 
    210                 215                 220                 


Gly Arg Leu Gly Pro Gln Arg Leu Leu Phe Gln Asn Leu Trp Lys Pro 
225                 230                 235                 240 


Arg Leu Asn Val Pro 
                245 


<210>  223
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Ser Leu Leu Leu Leu Val Val Ser Ala Leu His Ile Leu Ile Leu 
1               5                   10                  15      


Ile Leu Leu Phe Val Ala Thr Leu Asp Lys Ser Trp Trp Thr Leu Pro 
            20                  25                  30          


Gly Lys Glu Ser Leu Asn Leu Trp Tyr Asp Cys Thr Trp Asn Asn Asp 
        35                  40                  45              


Thr Lys Thr Trp Ala Cys Ser Asn Val Ser Glu Asn Gly Trp Leu Lys 
    50                  55                  60                  


Ala Val Gln Val Leu Met Val Leu Ser Leu Ile Leu Cys Cys Leu Ser 
65                  70                  75                  80  


Phe Ile Leu Phe Met Phe Gln Leu Tyr Thr Met Arg Arg Gly Gly Leu 
                85                  90                  95      


Phe Tyr Ala Thr Gly Leu Cys Gln Leu Cys Thr Ser Val Ala Val Phe 
            100                 105                 110         


Thr Gly Ala Leu Ile Tyr Ala Ile His Ala Glu Glu Ile Leu Glu Lys 
        115                 120                 125             


His Pro Arg Gly Gly Ser Phe Gly Tyr Cys Phe Ala Leu Ala Trp Val 
    130                 135                 140                 


Ala Phe Pro Leu Ala Leu Val Ser Gly Ile Ile Tyr Ile His Leu Arg 
145                 150                 155                 160 


Lys Arg Glu 
            


<210>  224
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  225
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Arg Leu Arg Val Arg Leu Leu Lys Arg Thr Trp Pro Leu Glu Val 
1               5                   10                  15      


Pro Glu Thr Glu Pro Thr Leu Gly His Leu Arg Ser His Leu Arg Gln 
            20                  25                  30          


Ser Leu Leu Cys Thr Trp Gly Tyr Ser Ser Asn Thr Arg Phe Thr Ile 
        35                  40                  45              


Thr Leu Asn Tyr Lys Asp Pro Leu Thr Gly Asp Glu Glu Thr Leu Ala 
    50                  55                  60                  


Ser Tyr Gly Ile Val Ser Gly Asp Leu Ile Cys Leu Ile Leu Gln Asp 
65                  70                  75                  80  


Asp Ile Pro Ala Pro Asn Ile Pro Ser Ser Thr Asp Ser Glu His Ser 
                85                  90                  95      


Ser Leu Gln Asn Asn Glu Gln Pro Ser Leu Ala Thr Ser Ser Asn Gln 
            100                 105                 110         


Thr Ser Met Gln Asp Glu Gln Pro Ser Asp Ser Phe Gln Gly Gln Ala 
        115                 120                 125             


Ala Gln Ser Gly Val Trp Asn Asp Asp Ser Met Leu Gly Pro Ser Gln 
    130                 135                 140                 


Asn Phe Glu Ala Glu Ser Ile Gln Asp Asn Ala His Met Ala Glu Gly 
145                 150                 155                 160 


Thr Gly Phe Tyr Pro Ser Glu Pro Met Leu Cys Ser Glu Ser Val Glu 
                165                 170                 175     


Gly Gln Val Pro His Ser Leu Glu Thr Leu Tyr Gln Ser Ala Asp Cys 
            180                 185                 190         


Ser Asp Ala Asn Asp Ala Leu Ile Val Leu Ile His Leu Leu Met Leu 
        195                 200                 205             


Glu Ser Gly Tyr Ile Pro Gln Gly Thr Glu Ala Lys Ala Leu Ser Met 
    210                 215                 220                 


Pro Glu Lys Trp Lys Leu Ser Gly Val Tyr Lys Leu Gln Tyr Met His 
225                 230                 235                 240 


Pro Leu Cys Glu Gly Ser Ser Ala Thr Leu Thr Cys Val Pro Leu Gly 
                245                 250                 255     


Asn Leu Ile Val Val Asn Ala Thr Leu Lys Ile Asn Asn Glu Ile Arg 
            260                 265                 270         


Ser Val Lys Arg Leu Gln Leu Leu Pro Glu Ser Phe Ile Cys Lys Glu 
        275                 280                 285             


Lys Leu Gly Glu Asn Val Ala Asn Ile Tyr Lys Asp Leu Gln Lys Leu 
    290                 295                 300                 


Ser Arg Leu Phe Lys Asp Gln Leu Val Tyr Pro Leu Leu Ala Phe Thr 
305                 310                 315                 320 


Arg Gln Ala Leu Asn Leu Pro Asp Val Phe Gly Leu Val Val Leu Pro 
                325                 330                 335     


Leu Glu Leu Lys Leu Arg Ile Phe Arg Leu Leu Asp Val Arg Ser Val 
            340                 345                 350         


Leu Ser Leu Ser Ala Val Cys Arg Asp Leu Phe Thr Ala Ser Asn Asp 
        355                 360                 365             


Pro Leu Leu Trp Arg Phe Leu Tyr Leu Arg Asp Phe Arg Asp Asn Thr 
    370                 375                 380                 


Val Arg Val Gln Asp Thr Asp Trp Lys Glu Leu Tyr Arg Lys Arg His 
385                 390                 395                 400 


Ile Gln Arg Lys Glu Ser Pro Lys Gly Arg Phe Val Met Leu Leu Pro 
                405                 410                 415     


Ser Ser Thr His Thr Ile Pro Phe Tyr Pro Asn Pro Leu His Pro Arg 
            420                 425                 430         


Pro Phe Pro Ser Ser Arg Leu Pro Pro Gly Ile Ile Gly Gly Glu Tyr 
        435                 440                 445             


Asp Gln Arg Pro Thr Leu Pro Tyr Val Gly Asp Pro Ile Ser Ser Leu 
    450                 455                 460                 


Ile Pro Gly Pro Gly Glu Thr Pro Ser Gln Phe Pro Pro Leu Arg Pro 
465                 470                 475                 480 


Arg Phe Asp Pro Val Gly Pro Leu Pro Gly Pro Asn Pro Ile Leu Pro 
                485                 490                 495     


Gly Arg Gly Gly Pro Asn Asp Arg Phe Pro Phe Arg Pro Ser Arg Gly 
            500                 505                 510         


Arg Pro Thr Asp Gly Arg Leu Ser Phe Met 
        515                 520         


<210>  226
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  227
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  227

Met Lys Leu Ala Asn Trp Tyr Trp Leu Ser Ser Ala Val Leu Ala Thr 
1               5                   10                  15      


Tyr Gly Phe Leu Val Val Ala Asn Asn Glu Thr Glu Glu Ile Lys Asp 
            20                  25                  30          


Glu Arg Ala Lys Asp Val Cys Pro Val Arg Leu Glu Ser Arg Gly Lys 
        35                  40                  45              


Cys Glu Glu Ala Gly Glu Cys Pro Tyr Gln Val Ser Leu Pro Pro Leu 
    50                  55                  60                  


Thr Ile Gln Leu Pro Lys Gln Phe Ser Arg Ile Glu Glu Val Phe Lys 
65                  70                  75                  80  


Glu Val Gln Asn Leu Lys Glu Ile Val Asn Ser Leu Lys Lys Ser Cys 
                85                  90                  95      


Gln Asp Cys Lys Leu Gln Ala Asp Asp Asn Gly Asp Pro Gly Arg Asn 
            100                 105                 110         


Gly Leu Leu Leu Pro Ser Thr Gly Ala Pro Gly Glu Val Gly Asp Asn 
        115                 120                 125             


Arg Val Arg Glu Leu Glu Ser Glu Val Asn Lys Leu Ser Ser Glu Leu 
    130                 135                 140                 


Lys Asn Ala Lys Glu Glu Ile Asn Val Leu His Gly Arg Leu Glu Lys 
145                 150                 155                 160 


Leu Asn Leu Val Asn Met Asn Asn Ile Glu Asn Tyr Val Asp Ser Lys 
                165                 170                 175     


Val Ala Asn Leu Thr Phe Val Val Asn Ser Leu Asp Gly Lys Cys Ser 
            180                 185                 190         


Lys Cys Pro Ser Gln Glu Gln Ile Gln Ser Arg Pro Val Gln His Leu 
        195                 200                 205             


Ile Tyr Lys Asp Cys Ser Asp Tyr Tyr Ala Ile Gly Lys Arg Ser Ser 
    210                 215                 220                 


Glu Thr Tyr Arg Val Thr Pro Asp Pro Lys Asn Ser Ser Phe Glu Val 
225                 230                 235                 240 


Tyr Cys Asp Met Glu Thr Met Gly Gly Gly Trp Thr Val Leu Gln Ala 
                245                 250                 255     


Arg Leu Asp Gly Ser Thr Asn Phe Thr Arg Thr Trp Gln Asp Tyr Lys 
            260                 265                 270         


Ala Gly Phe Gly Asn Leu Arg Arg Glu Phe Trp Leu Gly Asn Asp Lys 
        275                 280                 285             


Ile His Leu Leu Thr Lys Ser Lys Glu Met Ile Leu Arg Ile Asp Leu 
    290                 295                 300                 


Glu Asp Phe Asn Gly Val Glu Leu Tyr Ala Leu Tyr Asp Gln Phe Tyr 
305                 310                 315                 320 


Val Ala Asn Glu Phe Leu Lys Tyr Arg Leu His Val Gly Asn Tyr Asn 
                325                 330                 335     


Gly Thr Ala Gly Asp Ala Leu Arg Phe Asn Lys His Tyr Asn His Asp 
            340                 345                 350         


Leu Lys Phe Phe Thr Thr Pro Asp Lys Asp Asn Asp Arg Tyr Pro Ser 
        355                 360                 365             


Gly Asn Cys Gly Leu Tyr Tyr Ser Ser Gly Trp Trp Phe Asp Ala Cys 
    370                 375                 380                 


Leu Ser Ala Asn Leu Asn Gly Lys Tyr Tyr His Gln Lys Tyr Arg Gly 
385                 390                 395                 400 


Val Arg Asn Gly Ile Phe Trp Gly Thr Trp Pro Gly Val Ser Glu Ala 
                405                 410                 415     


His Pro Gly Gly Tyr Lys Ser Ser Phe Lys Glu Ala Lys Met Met Ile 
            420                 425                 430         


Arg Pro Lys His Phe Lys Pro 
        435                 


<210>  228
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Val Asn Glu Gly Pro Asn Gln Glu Glu Ser Asp Asp Thr Pro Val 
1               5                   10                  15      


Pro Glu Ser Ala Leu Gln Ala Asp Pro Ser Val Ser Val His Pro Ser 
            20                  25                  30          


Val Ser Val His Pro Ser Val Ser Ile Asn Pro Ser Val Ser Val His 
        35                  40                  45              


Pro Ser Ser Ser Ala His Pro Ser Ala Leu Ala Gln Pro Ser Gly Leu 
    50                  55                  60                  


Ala His Pro Ser Ser Ser Gly Pro Glu Asp Leu Ser Val Ile Lys Val 
65                  70                  75                  80  


Ser Arg Arg Arg Trp Ala Val Val Leu Val Phe Ser Cys Tyr Ser Met 
                85                  90                  95      


Cys Asn Ser Phe Gln Trp Ile Gln Tyr Gly Ser Ile Asn Asn Ile Phe 
            100                 105                 110         


Met His Phe Tyr Gly Val Ser Ala Phe Ala Ile Asp Trp Leu Ser Met 
        115                 120                 125             


Cys Tyr Met Leu Thr Tyr Ile Pro Leu Leu Leu Pro Val Ala Trp Leu 
    130                 135                 140                 


Leu Glu Lys Phe Gly Leu Arg Thr Ile Ala Leu Thr Gly Ser Ala Leu 
145                 150                 155                 160 


Asn Cys Leu Gly Ala Trp Val Lys Leu Gly Ser Leu Lys Pro His Leu 
                165                 170                 175     


Phe Pro Val Thr Val Val Gly Gln Leu Ile Cys Ser Val Ala Gln Val 
            180                 185                 190         


Phe Ile Leu Gly Met Pro Ser Arg Ile Ala Ser Val Trp Phe Gly Ala 
        195                 200                 205             


Asn Glu Val Ser Thr Ala Cys Ser Val Ala Val Phe Gly Asn Gln Leu 
    210                 215                 220                 


Gly Ile Ala Ile Gly Phe Leu Val Pro Pro Val Leu Val Pro Asn Ile 
225                 230                 235                 240 


Glu Asp Arg Asp Glu Leu Ala Tyr His Ile Ser Ile Met Phe Tyr Ile 
                245                 250                 255     


Ile Gly Gly Val Ala Thr Leu Leu Leu Ile Leu Val Ile Ile Val Phe 
            260                 265                 270         


Lys Glu Lys Pro Lys Tyr Pro Pro Ser Arg Ala Gln Ser Leu Ser Tyr 
        275                 280                 285             


Ala Leu Thr Ser Pro Asp Ala Ser Tyr Leu Gly Ser Ile Ala Arg Leu 
    290                 295                 300                 


Phe Lys Asn Leu Asn Phe Val Leu Leu Val Ile Thr Tyr Gly Leu Asn 
305                 310                 315                 320 


Ala Gly Ala Phe Tyr Ala Leu Ser Thr Leu Leu Asn Arg Met Val Ile 
                325                 330                 335     


Trp His Tyr Pro Gly Glu Glu Val Asn Ala Gly Arg Ile Gly Leu Thr 
            340                 345                 350         


Ile Val Ile Ala Gly Met Leu Gly Ala Val Ile Ser Gly Ile Trp Leu 
        355                 360                 365             


Asp Arg Ser Lys Thr Tyr Lys Glu Thr Thr Leu Val Val Tyr Ile Met 
    370                 375                 380                 


Thr Leu Val Gly Met Val Val Tyr Thr Phe Thr Leu Asn Leu Gly His 
385                 390                 395                 400 


Leu Trp Val Val Phe Ile Thr Ala Gly Thr Met Gly Phe Phe Met Thr 
                405                 410                 415     


Gly Tyr Leu Pro Leu Gly Phe Glu Phe Ala Val Glu Leu Thr Tyr Pro 
            420                 425                 430         


Glu Ser Glu Gly Ile Ser Ser Gly Leu Leu Asn Ile Ser Ala Gln Val 
        435                 440                 445             


Phe Gly Ile Ile Phe Thr Ile Ser Gln Gly Gln Ile Ile Asp Asn Tyr 
    450                 455                 460                 


Gly Thr Lys Pro Gly Asn Ile Phe Leu Cys Val Phe Leu Thr Leu Gly 
465                 470                 475                 480 


Ala Ala Leu Thr Ala Phe Ile Lys Ala Asp Leu Arg Arg Gln Lys Ala 
                485                 490                 495     


Asn Lys Glu Thr Leu Glu Asn Lys Leu Gln Glu Glu Glu Glu Glu Ser 
            500                 505                 510         


Asn Thr Ser Lys Val Pro Thr Ala Val Ser Glu Asp His Leu 
        515                 520                 525     


<210>  229
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  229

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 175 


<210>  230
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  231
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  231

Met Thr Asp Leu Tyr Tyr Leu Ser Gln Thr Asp Gly Ala Gly Asp Trp 
1               5                   10                  15      


Arg Glu Lys Glu Ala Lys Asp Leu Thr Glu Leu Val Gln Arg Arg Ile 
            20                  25                  30          


Thr Tyr Leu Gln Asn Pro Lys Asp Cys Ser Lys Ala Lys Lys Leu Val 
        35                  40                  45              


Cys Asn Ile Asn Lys Gly Cys Gly Tyr Gly Cys Gln Leu His His Val 
    50                  55                  60                  


Val Tyr Cys Phe Met Ile Ala Tyr Gly Thr Gln Arg Thr Leu Ile Leu 
65                  70                  75                  80  


Glu Ser Gln Asn Trp Arg Tyr Ala Thr Gly Gly Trp Glu Thr Val Phe 
                85                  90                  95      


Arg Pro Val Ser Glu Thr Cys Thr Asp Arg Ser Gly Ile Ser Thr Gly 
            100                 105                 110         


His Trp Ser Gly Glu Val Lys Asp Lys Asn Val Gln Val Val Glu Leu 
        115                 120                 125             


Pro Ile Val Asp Ser Leu His Pro Arg Pro Pro Tyr Leu Pro Leu Ala 
    130                 135                 140                 


Val Pro Glu Asp Leu Ala Asp Arg Leu Val Arg Val His Gly Asp Pro 
145                 150                 155                 160 


Ala Val Trp Trp Val Ser Gln Phe Val Lys Tyr Leu Ile Arg Pro Gln 
                165                 170                 175     


Pro Trp Leu Glu Lys Glu Ile Glu Glu Ala Thr Lys Lys Leu Gly Phe 
            180                 185                 190         


Lys His Pro Val Ile Gly Val His Val Arg Arg Thr Asp Lys Val Gly 
        195                 200                 205             


Thr Glu Ala Ala Phe His Pro Ile Glu Glu Tyr Met Val His Val Glu 
    210                 215                 220                 


Glu His Phe Gln Leu Leu Ala Arg Arg Met Gln Val Asp Lys Lys Arg 
225                 230                 235                 240 


Val Tyr Leu Ala Thr Asp Asp Pro Ser Leu Leu Lys Glu Ala Lys Thr 
                245                 250                 255     


Lys Tyr Pro Asn Tyr Glu Phe Ile Ser Asp Asn Ser Ile Ser Trp Ser 
            260                 265                 270         


Ala Gly Leu His Asn Arg Tyr Thr Glu Asn Ser Leu Arg Gly Val Ile 
        275                 280                 285             


Leu Asp Ile His Phe Leu Ser Gln Ala Asp Phe Leu Val Cys Thr Phe 
    290                 295                 300                 


Ser Ser Gln Val Cys Arg Val Ala Tyr Glu Ile Met Gln Thr Leu His 
305                 310                 315                 320 


Pro Asp Ala Ser Ala Asn Phe His Ser Leu Asp Asp Ile Tyr Tyr Phe 
                325                 330                 335     


Gly Gly Gln Asn Ala His Asn Gln Ile Ala Ile Tyr Ala His Gln Pro 
            340                 345                 350         


Arg Thr Ala Asp Glu Ile Pro Met Glu Pro Gly Asp Ile Ile Gly Val 
        355                 360                 365             


Ala Gly Asn His Trp Asp Gly Tyr Ser Lys Gly Val Asn Arg Lys Leu 
    370                 375                 380                 


Gly Arg Thr Gly Leu Tyr Pro Ser Tyr Lys Val Arg Glu Lys Ile Glu 
385                 390                 395                 400 


Thr Val Lys Tyr Pro Thr Tyr Pro Glu Ala Glu Lys 
                405                 410         


<210>  232
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Ala Glu Leu Thr Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Gly Phe Ile Lys Asp Val His Glu Asp Ser Leu Thr Val Val Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Glu Arg Gln Val Pro Phe Asn Glu Val Arg 
        35                  40                  45              


Leu Pro Pro Pro Pro Asp Ile Lys Lys Glu Ile Ser Glu Gly Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Asp Gln Glu Pro Cys Gly Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Met Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Phe Glu Arg Leu 
            100                 105                 110         


Arg Pro Val Asn Gln Asn Lys Thr Val Lys Lys Asn Thr Phe Phe Lys 
        115                 120                 125             


Cys Thr Val Asp Val Pro Glu Asp Leu Arg Glu Ala Cys Ala Asn Glu 
    130                 135                 140                 


Asn Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Cys Arg Ile Phe 
145                 150                 155                 160 


Tyr His Pro Glu Thr Thr Gln Leu Met Ile Leu Ser Ala Ser Glu Ala 
                165                 170                 175     


Thr Val Lys Arg Val Asn Ile Leu Ser Asp Met His Leu Arg Ser Ile 
            180                 185                 190         


Arg Thr Lys Leu Met Leu Met Ser Arg Asn Glu Glu Ala Thr Lys His 
        195                 200                 205             


Leu Glu Cys Thr Lys Gln Leu Ala Ala Ala Phe His Glu Glu Phe Val 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ser Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Glu Leu Asp 
                245                 250                 255     


Glu Asp Thr Gly Thr Phe Arg Ile Tyr Gly Glu Ser Ala Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Gly Phe Leu Glu Phe Val Glu Asp Phe Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Val Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Gly 
305                 310                 315                 320 


Asp Asn Glu Asn Lys Leu Pro Arg Glu Asp Gly Met Val Pro Phe Val 
                325                 330                 335     


Phe Val Gly Thr Lys Glu Ser Ile Gly Asn Val Gln Val Leu Leu Glu 
            340                 345                 350         


Tyr His Ile Ala Tyr Leu Lys Glu Val Glu Gln Leu Arg Met Glu Arg 
        355                 360                 365             


Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ser Arg Ser Tyr Ser 
    370                 375                 380                 


Gly Arg Gly Arg Gly Arg Arg Gly Pro Asn Tyr Thr Ser Gly Tyr Gly 
385                 390                 395                 400 


Thr Asn Ser Glu Leu Ser Asn Pro Ser Glu Thr Glu Ser Glu Arg Lys 
                405                 410                 415     


Asp Glu Leu Ser Asp Trp Ser Leu Ala Gly Glu Asp Asp Arg Asp Ser 
            420                 425                 430         


Arg His Gln Arg Asp Ser Arg Arg Arg Pro Gly Gly Arg Gly Arg Ser 
        435                 440                 445             


Val Ser Gly Gly Arg Gly Arg Gly Gly Pro Arg Gly Gly Lys Ser Ser 
    450                 455                 460                 


Ile Ser Ser Val Leu Lys Asp Pro Asp Ser Asn Pro Tyr Ser Leu Leu 
465                 470                 475                 480 


Asp Asn Thr Glu Ser Asp Gln Thr Ala Asp Thr Asp Ala Ser Glu Ser 
                485                 490                 495     


His His Ser Thr Asn Arg Arg Arg Arg Ser Arg Arg Arg Arg Thr Asp 
            500                 505                 510         


Glu Asp Ala Val Leu Met Asp Gly Met Thr Glu Ser Asp Thr Ala Ser 
        515                 520                 525             


Val Asn Glu Asn Gly Leu Val Thr Val Ala Asp Tyr Ile Ser Arg Ala 
    530                 535                 540                 


Glu Ser Gln Ser Arg Gln Arg Asn Leu Pro Arg Glu Thr Leu Ala Lys 
545                 550                 555                 560 


Asn Lys Lys Glu Met Ala Lys Asp Val Ile Glu Glu His Gly Pro Ser 
                565                 570                 575     


Glu Lys Ala Ile Asn Gly Pro Thr Ser Ala Ser Gly Asp Asp Ile Ser 
            580                 585                 590         


Lys Leu Gln Arg Thr Pro Gly Glu Glu Lys Ile Asn Thr Leu Lys Glu 
        595                 600                 605             


Glu Asn Thr Gln Glu Ala Ala Val Leu Asn Gly Val Ser 
    610                 615                 620     


<210>  233
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  234
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Ser Asn Met Glu Asn Ser Phe Asp Asp Val Ser Cys Leu Ser Pro 
1               5                   10                  15      


Gln Asn Leu Gly Ser Ser Ser Pro Ser Lys Lys Gln Ser Lys Glu Asn 
            20                  25                  30          


Thr Ile Thr Ile Asn Cys Val Thr Phe Pro His Pro Asp Thr Met Pro 
        35                  40                  45              


Glu Gln Gln Leu Leu Lys Pro Thr Glu Trp Ser Tyr Cys Asp Tyr Phe 
    50                  55                  60                  


Trp Ala Asp Lys Lys Asp Pro Gln Gly Asn Gly Thr Val Ala Gly Phe 
65                  70                  75                  80  


Glu Leu Leu Leu Gln Lys Gln Leu Lys Gly Lys Gln Met Gln Lys Glu 
                85                  90                  95      


Met Ser Glu Phe Ile Arg Glu Arg Ile Lys Ile Glu Glu Asp Tyr Ala 
            100                 105                 110         


Lys Asn Leu Ala Lys Leu Ser Gln Asn Ser Leu Ala Ser Gln Glu Glu 
        115                 120                 125             


Gly Ser Leu Gly Glu Ala Trp Ala Gln Val Lys Lys Ser Leu Ala Asp 
    130                 135                 140                 


Glu Ala Glu Val His Leu Lys Phe Ser Ala Lys Leu His Ser Glu Val 
145                 150                 155                 160 


Glu Lys Pro Leu Met Asn Phe Arg Glu Asn Phe Lys Lys Asp Met Lys 
                165                 170                 175     


Lys Cys Asp His His Ile Ala Asp Leu Arg Lys Gln Leu Ala Ser Arg 
            180                 185                 190         


Tyr Ala Ser Val Glu Lys Ala Arg Lys Ala Leu Thr Glu Arg Gln Arg 
        195                 200                 205             


Asp Leu Glu Met Lys Thr Gln Gln Leu Glu Ile Lys Leu Ser Asn Lys 
    210                 215                 220                 


Thr Glu Glu Asp Ile Lys Lys Ala Arg Arg Lys Ser Thr Gln Ala Gly 
225                 230                 235                 240 


Asp Asp Leu Met Arg Cys Val Asp Leu Tyr Asn Gln Ala Gln Ser Lys 
                245                 250                 255     


Trp Phe Glu Glu Met Val Thr Thr Thr Leu Glu Leu Glu Arg Leu Glu 
            260                 265                 270         


Val Glu Arg Val Glu Met Ile Arg Gln His Leu Cys Gln Tyr Thr Gln 
        275                 280                 285             


Leu Arg His Glu Thr Asp Met Phe Asn Gln Ser Thr Val Glu Pro Val 
    290                 295                 300                 


Asp Gln Leu Leu Arg Lys Val Asp Pro Ala Lys Asp Arg Glu Leu Trp 
305                 310                 315                 320 


Val Arg Glu His Lys Thr Gly Asn Ile Arg Pro Val Asp Met Glu Ile 
                325                 330                 335     


<210>  235
<211>  591
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Ala Pro Glu Ile Asn Leu Pro Gly Pro Met Ser Leu Ile Asp Asn 
1               5                   10                  15      


Thr Lys Gly Gln Leu Val Val Asn Pro Glu Ala Leu Lys Ile Leu Ser 
            20                  25                  30          


Ala Ile Thr Gln Pro Val Val Val Val Ala Ile Val Gly Leu Tyr Arg 
        35                  40                  45              


Thr Gly Lys Ser Tyr Leu Met Asn Lys Leu Ala Gly Lys Lys Asn Gly 
    50                  55                  60                  


Phe Ser Leu Gly Ser Thr Val Lys Ser His Thr Lys Gly Ile Trp Met 
65                  70                  75                  80  


Trp Cys Val Pro His Pro Lys Lys Pro Glu His Thr Leu Val Leu Leu 
                85                  90                  95      


Asp Thr Glu Gly Leu Gly Asp Ile Glu Lys Gly Asp Asn Glu Asn Asp 
            100                 105                 110         


Ser Trp Ile Phe Ala Leu Ala Ile Leu Leu Ser Ser Thr Phe Val Tyr 
        115                 120                 125             


Asn Ser Met Gly Thr Ile Asn Gln Gln Ala Met Asp Gln Leu His Tyr 
    130                 135                 140                 


Val Thr Glu Leu Thr Asp Arg Ile Lys Ala Asn Ser Ser Pro Gly Asn 
145                 150                 155                 160 


Asn Ser Val Asp Asp Ser Ala Asp Phe Val Ser Phe Phe Pro Ala Phe 
                165                 170                 175     


Val Trp Thr Leu Arg Asp Phe Thr Leu Glu Leu Glu Val Asp Gly Glu 
            180                 185                 190         


Pro Ile Thr Ala Asp Asp Tyr Leu Glu Leu Ser Leu Lys Leu Arg Lys 
        195                 200                 205             


Gly Thr Asp Lys Lys Ser Lys Ser Phe Asn Asp Pro Arg Leu Cys Ile 
    210                 215                 220                 


Arg Lys Phe Phe Pro Lys Arg Lys Cys Phe Val Phe Asp Trp Pro Ala 
225                 230                 235                 240 


Pro Lys Lys Tyr Leu Ala His Leu Glu Gln Leu Lys Glu Glu Glu Leu 
                245                 250                 255     


Asn Pro Asp Phe Ile Glu Gln Val Ala Glu Phe Cys Ser Tyr Ile Leu 
            260                 265                 270         


Ser His Ser Asn Val Lys Thr Leu Ser Gly Gly Ile Pro Val Asn Gly 
        275                 280                 285             


Pro Arg Leu Glu Ser Leu Val Leu Thr Tyr Val Asn Ala Ile Ser Ser 
    290                 295                 300                 


Gly Asp Leu Pro Cys Met Glu Asn Ala Val Leu Ala Leu Ala Gln Ile 
305                 310                 315                 320 


Glu Asn Ser Ala Ala Val Glu Lys Ala Ile Ala His Tyr Glu Gln Gln 
                325                 330                 335     


Met Gly Gln Lys Val Gln Leu Pro Thr Glu Thr Leu Gln Glu Leu Leu 
            340                 345                 350         


Asp Leu His Arg Asp Ser Glu Arg Glu Ala Ile Glu Val Phe Met Lys 
        355                 360                 365             


Asn Ser Phe Lys Asp Val Asp Gln Met Phe Gln Arg Lys Leu Gly Ala 
    370                 375                 380                 


Gln Leu Glu Ala Arg Arg Asp Asp Phe Cys Lys Gln Asn Ser Lys Ala 
385                 390                 395                 400 


Ser Ser Asp Cys Cys Met Ala Leu Leu Gln Asp Ile Phe Gly Pro Leu 
                405                 410                 415     


Glu Glu Asp Val Lys Gln Gly Thr Phe Ser Lys Pro Gly Gly Tyr Arg 
            420                 425                 430         


Leu Phe Thr Gln Lys Leu Gln Glu Leu Lys Asn Lys Tyr Tyr Gln Val 
        435                 440                 445             


Pro Arg Lys Gly Ile Gln Ala Lys Glu Val Leu Lys Lys Tyr Leu Glu 
    450                 455                 460                 


Ser Lys Glu Asp Val Ala Asp Ala Leu Leu Gln Thr Asp Gln Ser Leu 
465                 470                 475                 480 


Ser Glu Lys Glu Lys Ala Ile Glu Val Glu Arg Ile Lys Ala Glu Ser 
                485                 490                 495     


Ala Glu Ala Ala Lys Lys Met Leu Glu Glu Ile Gln Lys Lys Asn Glu 
            500                 505                 510         


Glu Met Met Glu Gln Lys Glu Lys Ser Tyr Gln Glu His Val Lys Gln 
        515                 520                 525             


Leu Thr Glu Lys Met Glu Arg Asp Arg Ala Gln Leu Met Ala Glu Gln 
    530                 535                 540                 


Glu Lys Thr Leu Ala Leu Lys Leu Gln Glu Gln Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Glu Gly Phe Glu Asn Glu Ser Lys Arg Leu Gln Lys Asp Ile Trp Asp 
                565                 570                 575     


Ile Gln Met Arg Ser Lys Ser Leu Glu Pro Ile Cys Asn Ile Leu 
            580                 585                 590     


<210>  236
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Ala Ala Gln Tyr Gly Ser Met Ser Phe Asn Pro Ser Thr Pro Gly 
1               5                   10                  15      


Ala Ser Tyr Gly Pro Gly Arg Gln Glu Pro Arg Asn Ser Gln Leu Arg 
            20                  25                  30          


Ile Val Leu Val Gly Lys Thr Gly Ala Gly Lys Ser Ala Thr Gly Asn 
        35                  40                  45              


Ser Ile Leu Gly Arg Lys Val Phe His Ser Gly Thr Ala Ala Lys Ser 
    50                  55                  60                  


Ile Thr Lys Lys Cys Glu Lys Arg Ser Ser Ser Trp Lys Glu Thr Glu 
65                  70                  75                  80  


Leu Val Val Val Asp Thr Pro Gly Ile Phe Asp Thr Glu Val Pro Asn 
                85                  90                  95      


Ala Glu Thr Ser Lys Glu Ile Ile Arg Cys Ile Leu Leu Thr Ser Pro 
            100                 105                 110         


Gly Pro His Ala Leu Leu Leu Val Val Pro Leu Gly Arg Tyr Thr Glu 
        115                 120                 125             


Glu Glu His Lys Ala Thr Glu Lys Ile Leu Lys Met Phe Gly Glu Arg 
    130                 135                 140                 


Ala Arg Ser Phe Met Ile Leu Ile Phe Thr Arg Lys Asp Asp Leu Gly 
145                 150                 155                 160 


Asp Thr Asn Leu His Asp Tyr Leu Arg Glu Ala Pro Glu Asp Ile Gln 
                165                 170                 175     


Asp Leu Met Asp Ile Phe Gly Asp Arg Tyr Cys Ala Leu Asn Asn Lys 
            180                 185                 190         


Ala Thr Gly Ala Glu Gln Glu Ala Gln Arg Ala Gln Leu Leu Gly Leu 
        195                 200                 205             


Ile Gln Arg Val Val Arg Glu Asn Lys Glu Gly Cys Tyr Thr Asn Arg 
    210                 215                 220                 


Met Tyr Gln Arg Ala Glu Glu Glu Ile Gln Lys Gln Thr Gln Ala Met 
225                 230                 235                 240 


Gln Glu Leu His Arg Val Glu Leu Glu Arg Glu Lys Ala Arg Ile Arg 
                245                 250                 255     


Glu Glu Tyr Glu Glu Lys Ile Arg Lys Leu Glu Asp Lys Val Glu Gln 
            260                 265                 270         


Glu Lys Arg Lys Lys Gln Met Glu Lys Lys Leu Ala Glu Gln Glu Ala 
        275                 280                 285             


His Tyr Ala Val Arg Gln Gln Arg Ala Arg Thr Glu Val Glu Ser Lys 
    290                 295                 300                 


Asp Gly Ile Leu Glu Leu Ile Met Thr Ala Leu Gln Ile Ala Ser Phe 
305                 310                 315                 320 


Ile Leu Leu Arg Leu Phe Ala Glu Asp 
                325                 


<210>  237
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  237

Met Ala Ala Arg Arg Ala Leu His Phe Val Phe Lys Val Gly Asn Arg 
1               5                   10                  15      


Phe Gln Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Leu 
            20                  25                  30          


Arg His Glu Glu Phe Glu Glu Gly Cys Lys Ala Ala Cys Asn Gly Pro 
        35                  40                  45              


Tyr Asp Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp 
    50                  55                  60                  


Asp His Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr 
65                  70                  75                  80  


Lys Leu Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala 
                85                  90                  95      


Val Ser Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu 
            100                 105                 110         


Gly Val Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln 
        115                 120                 125             


Asn Arg Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala 
    130                 135                 140                 


Val Ser Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly 
145                 150                 155                 160 


Met Lys Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly 
                165                 170                 175     


Tyr Ala Asp Asn Gln Cys Lys Leu Glu Leu Gln Gly Val Lys Gly Gly 
            180                 185                 190         


Val Asp His Ala Ala Ala Phe Gly Arg Ile Ala Phe Ser Cys Pro Gln 
        195                 200                 205             


Lys Glu Leu Pro Asp Leu Glu Asp Leu Met Lys Arg Glu Asn Gln Lys 
    210                 215                 220                 


Ile Leu Thr Pro Leu Val Ser Leu Asp Thr Pro Gly Lys Ala Thr Val 
225                 230                 235                 240 


Gln Val Val Ile Leu Ala Asp Pro Asp Gly His Glu Ile Cys Phe Val 
                245                 250                 255     


Gly Asp Glu Ala Phe Arg Glu Leu Ser Lys Met Asp Pro Glu Gly Ser 
            260                 265                 270         


Lys Leu Leu Asp Asp Ala Met Ala Ala Asp Lys Ser Asp Glu Trp Phe 
        275                 280                 285             


Ala Lys His Asn Lys Pro Lys Ala Ser Gly 
    290                 295             


<210>  238
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  238

Met Arg Leu Leu Pro Leu Ala Pro Gly Arg Leu Arg Arg Gly Ser Pro 
1               5                   10                  15      


Arg His Leu Pro Ser Cys Ser Pro Ala Leu Leu Leu Leu Val Leu Gly 
            20                  25                  30          


Gly Cys Leu Gly Val Phe Gly Val Ala Ala Gly Thr Arg Arg Pro Asn 
        35                  40                  45              


Val Val Leu Leu Leu Thr Asp Asp Gln Asp Glu Val Leu Gly Gly Met 
    50                  55                  60                  


Thr Pro Leu Lys Lys Thr Lys Ala Leu Ile Gly Glu Met Gly Met Thr 
65                  70                  75                  80  


Phe Ser Ser Ala Tyr Val Pro Ser Ala Leu Cys Cys Pro Ser Arg Ala 
                85                  90                  95      


Ser Ile Leu Thr Gly Lys Tyr Pro His Asn His His Val Val Asn Asn 
            100                 105                 110         


Thr Leu Glu Gly Asn Cys Ser Ser Lys Ser Trp Gln Lys Ile Gln Glu 
        115                 120                 125             


Pro Asn Thr Phe Pro Ala Ile Leu Arg Ser Met Cys Gly Tyr Gln Thr 
    130                 135                 140                 


Phe Phe Ala Gly Lys Tyr Leu Asn Glu Tyr Gly Ala Pro Asp Ala Gly 
145                 150                 155                 160 


Gly Leu Glu His Val Pro Leu Gly Trp Ser Tyr Trp Tyr Ala Leu Glu 
                165                 170                 175     


Lys Asn Ser Lys Tyr Tyr Asn Tyr Thr Leu Ser Ile Asn Gly Lys Ala 
            180                 185                 190         


Arg Lys His Gly Glu Asn Tyr Ser Val Asp Tyr Leu Thr Asp Val Leu 
        195                 200                 205             


Ala Asn Val Ser Leu Asp Phe Leu Asp Tyr Lys Ser Asn Phe Glu Pro 
    210                 215                 220                 


Phe Phe Met Met Ile Ala Thr Pro Ala Pro His Ser Pro Trp Thr Ala 
225                 230                 235                 240 


Ala Pro Gln Tyr Gln Lys Ala Phe Gln Asn Val Phe Ala Pro Arg Asn 
                245                 250                 255     


Lys Asn Phe Asn Ile His Gly Thr Asn Lys His Trp Leu Ile Arg Gln 
            260                 265                 270         


Ala Lys Thr Pro Met Thr Asn Ser Ser Ile Gln Phe Leu Asp Asn Ala 
        275                 280                 285             


Phe Arg Lys Arg Trp Gln Thr Leu Leu Ser Val Asp Asp Leu Val Glu 
    290                 295                 300                 


Lys Leu Val Lys Arg Leu Glu Phe Thr Gly Glu Leu Asn Asn Thr Tyr 
305                 310                 315                 320 


Ile Phe Tyr Thr Ser Asp Asn Gly Tyr His Thr Gly Gln Phe Ser Leu 
                325                 330                 335     


Pro Ile Asp Lys Arg Gln Leu Tyr Glu Phe Asp Ile Lys Val Pro Leu 
            340                 345                 350         


Leu Val Arg Gly Pro Gly Ile Lys Pro Asn Gln Thr Ser Lys Met Leu 
        355                 360                 365             


Val Ala Asn Ile Asp Leu Gly Pro Thr Ile Leu Asp Ile Ala Gly Tyr 
    370                 375                 380                 


Asp Leu Asn Lys Thr Gln Met Asp Gly Met Ser Leu Leu Pro Ile Leu 
385                 390                 395                 400 


Arg Gly Ala Ser Asn Leu Thr Trp Arg Ser Asp Val Leu Val Glu Tyr 
                405                 410                 415     


Gln Gly Glu Gly Arg Asn Val Thr Asp Pro Thr Cys Pro Ser Leu Ser 
            420                 425                 430         


Pro Gly Val Ser Gln Cys Phe Pro Asp Cys Val Cys Glu Asp Ala Tyr 
        435                 440                 445             


Asn Asn Thr Tyr Ala Cys Val Arg Thr Met Ser Ala Leu Trp Asn Leu 
    450                 455                 460                 


Gln Tyr Cys Glu Phe Asp Asp Gln Glu Val Phe Val Glu Val Tyr Asn 
465                 470                 475                 480 


Leu Thr Ala Asp Pro Asp Gln Ile Thr Asn Ile Ala Lys Thr Ile Asp 
                485                 490                 495     


Pro Glu Leu Leu Gly Lys Met Asn Tyr Arg Leu Met Met Leu Gln Ser 
            500                 505                 510         


Cys Ser Gly Pro Thr Cys Arg Thr Pro Gly Val Phe Asp Pro Gly Tyr 
        515                 520                 525             


Arg Phe Asp Pro Arg Leu Met Phe Ser Asn Arg Gly Ser Val Arg Thr 
    530                 535                 540                 


Arg Arg Phe Ser Lys His Leu Leu 
545                 550         


<210>  239
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  239

Met Glu Ala Val Ala Lys Phe Asp Phe Thr Ala Ser Gly Glu Asp Glu 
1               5                   10                  15      


Leu Ser Phe His Thr Gly Asp Val Leu Lys Ile Leu Ser Asn Gln Glu 
            20                  25                  30          


Glu Trp Phe Lys Ala Glu Leu Gly Ser Gln Glu Gly Tyr Val Pro Lys 
        35                  40                  45              


Asn Phe Ile Asp Ile Gln Phe Pro Lys Trp Phe His Glu Gly Leu Ser 
    50                  55                  60                  


Arg His Gln Ala Glu Asn Leu Leu Met Gly Lys Glu Val Gly Phe Phe 
65                  70                  75                  80  


Ile Ile Arg Ala Ser Gln Ser Ser Pro Gly Asp Phe Ser Ile Ser Val 
                85                  90                  95      


Arg His Glu Asp Asp Val Gln His Phe Lys Val Met Arg Asp Asn Lys 
            100                 105                 110         


Gly Asn Tyr Phe Leu Trp Thr Glu Lys Phe Pro Ser Leu Asn Lys Leu 
        115                 120                 125             


Val Asp Tyr Tyr Arg Thr Asn Ser Ile Ser Arg Gln Lys Gln Ile Phe 
    130                 135                 140                 


Leu Arg Asp Arg Thr Arg Glu Asp Gln Gly His Arg Gly Asn Ser Leu 
145                 150                 155                 160 


Asp Arg Arg Ser Gln Gly Gly Pro His Leu Ser Gly Ala Val Gly Glu 
                165                 170                 175     


Glu Ile Arg Pro Ser Met Asn Arg Lys Leu Ser Asp His Pro Pro Thr 
            180                 185                 190         


Leu Pro Leu Gln Gln His Gln His Gln Pro Gln Pro Pro Gln Tyr Ala 
        195                 200                 205             


Pro Ala Pro Gln Gln Leu Gln Gln Pro Pro Gln Gln Arg Tyr Leu Gln 
    210                 215                 220                 


His His His Phe His Gln Glu Arg Arg Gly Gly Ser Leu Asp Ile Asn 
225                 230                 235                 240 


Asp Gly His Cys Gly Thr Gly Leu Gly Ser Glu Met Asn Ala Ala Leu 
                245                 250                 255     


Met His Arg Arg His Thr Asp Pro Val Gln Leu Gln Ala Ala Gly Arg 
            260                 265                 270         


Val Arg Trp Ala Arg Ala Leu Tyr Asp Phe Glu Ala Leu Glu Asp Asp 
        275                 280                 285             


Glu Leu Gly Phe His Ser Gly Glu Val Val Glu Val Leu Asp Ser Ser 
    290                 295                 300                 


Asn Pro Ser Trp Trp Thr Gly Arg Leu His Asn Lys Leu Gly Leu Phe 
305                 310                 315                 320 


Pro Ala Asn Tyr Val Ala Pro Met Thr Arg 
                325                 330 


<210>  240
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
        35                  40                  45              


His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
    50                  55                  60                  


Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                85                  90                  95      


Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
            100                 105                 110         


Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
        115                 120                 125             


Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
    130                 135                 140                 


Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
145                 150                 155                 160 


Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                165                 170                 175     


Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
            180                 185                 190         


Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
        195                 200                 205             


Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
    210                 215                 220                 


Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
225                 230                 235                 240 


Leu 
    


<210>  241
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Leu Gly Met Ile Lys Asn Ser Leu Phe Gly Ser Val Glu Thr Trp 
1               5                   10                  15      


Pro Trp Gln Val Leu Ser Lys Gly Asp Lys Glu Glu Val Ala Tyr Glu 
            20                  25                  30          


Glu Arg Ala Cys Glu Gly Gly Lys Phe Ala Thr Val Glu Val Thr Asp 
        35                  40                  45              


Lys Pro Val Asp Glu Ala Leu Arg Glu Ala Met Pro Lys Val Ala Lys 
    50                  55                  60                  


Tyr Ala Gly Gly Thr Asn Asp Lys Gly Ile Gly Met Gly Met Thr Val 
65                  70                  75                  80  


Pro Ile Ser Phe Ala Val Phe Pro Asn Glu Asp Gly Ser Leu Gln Lys 
                85                  90                  95      


Lys Leu Lys Val Trp Phe Arg Ile Pro Asn Gln Phe Gln Ser Asp Pro 
            100                 105                 110         


Pro Ala Pro Ser Asp Lys Ser Val Lys Ile Glu Glu Arg Glu Gly Ile 
        115                 120                 125             


Thr Val Tyr Ser Met Gln Phe Gly Gly Tyr Ala Lys Glu Ala Asp Tyr 
    130                 135                 140                 


Val Ala Gln Ala Thr Arg Leu Arg Ala Ala Leu Glu Gly Thr Ala Thr 
145                 150                 155                 160 


Tyr Arg Gly Asp Ile Tyr Phe Cys Thr Gly Tyr Asp Pro Pro Met Lys 
                165                 170                 175     


Pro Tyr Gly Arg Arg Asn Glu Ile Trp Leu Leu Lys Thr 
            180                 185                 


<210>  242
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Pro Glu Pro Val Lys Ser Ala Pro Val Pro Lys Lys Gly Ser Lys 
1               5                   10                  15      


Lys Ala Ile Asn Lys Ala Gln Lys Lys Asp Gly Lys Lys Arg Lys Arg 
            20                  25                  30          


Ser Arg Lys Glu Ser Tyr Ser Val Tyr Val Tyr Lys Val Leu Lys Gln 
        35                  40                  45              


Val His Pro Asp Thr Gly Ile Ser Ser Lys Ala Met Gly Ile Met Asn 
    50                  55                  60                  


Ser Phe Val Asn Asp Ile Phe Glu Arg Ile Ala Gly Glu Ala Ser Arg 
65                  70                  75                  80  


Leu Ala His Tyr Asn Lys Arg Ser Thr Ile Thr Ser Arg Glu Ile Gln 
                85                  90                  95      


Thr Ala Val Arg Leu Leu Leu Pro Gly Glu Leu Ala Lys His Ala Val 
            100                 105                 110         


Ser Glu Gly Thr Lys Ala Val Thr Lys Tyr Thr Ser Ser Lys 
        115                 120                 125     


<210>  243
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  244
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  245
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Arg Pro Glu Asp Arg Met Phe His Ile Arg Ala Val Ile Leu Arg 
1               5                   10                  15      


Ala Leu Ser Leu Ala Phe Leu Leu Ser Leu Arg Gly Ala Gly Ala Ile 
            20                  25                  30          


Lys Ala Asp His Val Ser Thr Tyr Ala Ala Phe Val Gln Thr His Arg 
        35                  40                  45              


Pro Thr Gly Glu Phe Met Phe Glu Phe Asp Glu Asp Glu Met Phe Tyr 
    50                  55                  60                  


Val Asp Leu Asp Lys Lys Glu Thr Val Trp His Leu Glu Glu Phe Gly 
65                  70                  75                  80  


Gln Ala Phe Ser Phe Glu Ala Gln Gly Gly Leu Ala Asn Ile Ala Ile 
                85                  90                  95      


Leu Asn Asn Asn Leu Asn Thr Leu Ile Gln Arg Ser Asn His Thr Gln 
            100                 105                 110         


Ala Thr Asn Asp Pro Pro Glu Val Thr Val Phe Pro Lys Glu Pro Val 
        115                 120                 125             


Glu Leu Gly Gln Pro Asn Thr Leu Ile Cys His Ile Asp Lys Phe Phe 
    130                 135                 140                 


Pro Pro Val Leu Asn Val Thr Trp Leu Cys Asn Gly Glu Leu Val Thr 
145                 150                 155                 160 


Glu Gly Val Ala Glu Ser Leu Phe Leu Pro Arg Thr Asp Tyr Ser Phe 
                165                 170                 175     


His Lys Phe His Tyr Leu Thr Phe Val Pro Ser Ala Glu Asp Phe Tyr 
            180                 185                 190         


Asp Cys Arg Val Glu His Trp Gly Leu Asp Gln Pro Leu Leu Lys His 
        195                 200                 205             


Trp Glu Ala Gln Glu Pro Ile Gln Met Pro Glu Thr Thr Glu Thr Val 
    210                 215                 220                 


Leu Cys Ala Leu Gly Leu Val Leu Gly Leu Val Gly Ile Ile Val Gly 
225                 230                 235                 240 


Thr Val Leu Ile Ile Lys Ser Leu Arg Ser Gly His Asp Pro Arg Ala 
                245                 250                 255     


Gln Gly Thr Leu 
            260 


<210>  246
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ser His Gly Pro Lys Gln Pro Gly Ala Ala Ala Ala Pro Ala Gly 
1               5                   10                  15      


Gly Lys Ala Pro Gly Gln His Gly Gly Phe Val Val Thr Val Lys Gln 
            20                  25                  30          


Glu Arg Gly Glu Gly Pro Arg Ala Gly Glu Lys Gly Ser His Glu Glu 
        35                  40                  45              


Glu Pro Val Lys Lys Arg Gly Trp Pro Lys Gly Lys Lys Arg Lys Lys 
    50                  55                  60                  


Ile Leu Pro Asn Gly Pro Lys Ala Pro Val Thr Gly Tyr Val Arg Phe 
65                  70                  75                  80  


Leu Asn Glu Arg Arg Glu Gln Ile Arg Thr Arg His Pro Asp Leu Pro 
                85                  90                  95      


Phe Pro Glu Ile Thr Lys Met Leu Gly Ala Glu Trp Ser Lys Leu Gln 
            100                 105                 110         


Pro Thr Glu Lys Gln Arg Tyr Leu Asp Glu Ala Glu Arg Glu Lys Gln 
        115                 120                 125             


Gln Tyr Met Lys Glu Leu Arg Ala Tyr Gln Gln Ser Glu Ala Tyr Lys 
    130                 135                 140                 


Met Cys Thr Glu Lys Ile Gln Glu Lys Lys Ile Lys Lys Glu Asp Ser 
145                 150                 155                 160 


Ser Ser Gly Leu Met Asn Thr Leu Leu Asn Gly His Lys Gly Gly Asp 
                165                 170                 175     


Cys Asp Gly Phe Ser Thr Phe Asp Val Pro Ile Phe Thr Glu Glu Phe 
            180                 185                 190         


Leu Asp Gln Asn Lys Ala Arg Glu Ala Glu Leu Arg Arg Leu Arg Lys 
        195                 200                 205             


Met Asn Val Ala Phe Glu Glu Gln Asn Ala Val Leu Gln Arg His Thr 
    210                 215                 220                 


Gln Ser Met Ser Ser Ala Arg Glu Arg Leu Glu Gln Glu Leu Ala Leu 
225                 230                 235                 240 


Glu Glu Arg Arg Thr Leu Ala Leu Gln Gln Gln Leu Gln Ala Val Arg 
                245                 250                 255     


Gln Ala Leu Thr Ala Ser Phe Ala Ser Leu Pro Val Pro Gly Thr Gly 
            260                 265                 270         


Glu Thr Pro Thr Leu Gly Thr Leu Asp Phe Tyr Met Ala Arg Leu His 
        275                 280                 285             


Gly Ala Ile Glu Arg Asp Pro Ala Gln His Glu Lys Leu Ile Val Arg 
    290                 295                 300                 


Ile Lys Glu Ile Leu Ala Gln Val Ala Ser Glu His Leu 
305                 310                 315         


<210>  247
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  247

Met Pro Lys Arg Lys Ala Lys Gly Asp Ala Lys Gly Asp Lys Ala Lys 
1               5                   10                  15      


Val Lys Asp Glu Pro Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro 
            20                  25                  30          


Ala Pro Pro Lys Pro Glu Pro Arg Pro Lys Lys Ala Ser Ala Lys Lys 
        35                  40                  45              


Gly Glu Lys Leu Pro Lys Gly Arg Lys Gly Lys Ala Asp Ala Gly Lys 
    50                  55                  60                  


Asp Gly Asn Asn Pro Ala Lys Asn Arg Asp Ala Ser Thr Leu Gln Ser 
65                  70                  75                  80  


Gln Lys Ala Glu Gly Thr Gly Asp Ala Lys 
                85                  90  


<210>  248
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  248

Met Ser Ser Tyr Phe Val Asn Ser Thr Phe Pro Val Thr Leu Ala Ser 
1               5                   10                  15      


Gly Gln Glu Ser Phe Leu Gly Gln Leu Pro Leu Tyr Ser Ser Gly Tyr 
            20                  25                  30          


Ala Asp Pro Leu Arg His Tyr Pro Ala Pro Tyr Gly Pro Gly Pro Gly 
        35                  40                  45              


Gln Asp Lys Gly Phe Ala Thr Ser Ser Tyr Tyr Pro Pro Ala Gly Gly 
    50                  55                  60                  


Gly Tyr Gly Arg Ala Ala Pro Cys Asp Tyr Gly Pro Ala Pro Ala Phe 
65                  70                  75                  80  


Tyr Arg Glu Lys Glu Ser Ala Cys Ala Leu Ser Gly Ala Asp Glu Gln 
                85                  90                  95      


Pro Pro Phe His Pro Glu Pro Arg Lys Ser Asp Cys Ala Gln Asp Lys 
            100                 105                 110         


Ser Val Phe Gly Glu Thr Glu Glu Gln Lys Cys Ser Thr Pro Val Tyr 
        115                 120                 125             


Pro Trp Met Gln Arg Met Asn Ser Cys Asn Ser Ser Ser Phe Gly Pro 
    130                 135                 140                 


Ser Gly Arg Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe His Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
                165                 170                 175     


Ile Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Ser Lys Leu Leu 
        195                 200                 205             


Ser Ala Ser Gln Leu Ser Ala Glu Glu Glu Glu Glu Lys Gln Ala Glu 
    210                 215                 220                 


<210>  249
<211>  840
<212>  PRT
<213>  Homo sapiens

<400>  249

Met Ser Val Val Gly Ile Asp Leu Gly Phe Gln Ser Cys Tyr Val Ala 
1               5                   10                  15      


Val Ala Arg Ala Gly Gly Ile Glu Thr Ile Ala Asn Glu Tyr Ser Asp 
            20                  25                  30          


Arg Cys Thr Pro Ala Cys Ile Ser Phe Gly Pro Lys Asn Arg Ser Ile 
        35                  40                  45              


Gly Ala Ala Ala Lys Ser Gln Val Ile Ser Asn Ala Lys Asn Thr Val 
    50                  55                  60                  


Gln Gly Phe Lys Arg Phe His Gly Arg Ala Phe Ser Asp Pro Phe Val 
65                  70                  75                  80  


Glu Ala Glu Lys Ser Asn Leu Ala Tyr Asp Ile Val Gln Leu Pro Thr 
                85                  90                  95      


Gly Leu Thr Gly Ile Lys Val Thr Tyr Met Glu Glu Glu Arg Asn Phe 
            100                 105                 110         


Thr Thr Glu Gln Val Thr Ala Met Leu Leu Ser Lys Leu Lys Glu Thr 
        115                 120                 125             


Ala Glu Ser Val Leu Lys Lys Pro Val Val Asp Cys Val Val Ser Val 
    130                 135                 140                 


Pro Cys Phe Tyr Thr Asp Ala Glu Arg Arg Ser Val Met Asp Ala Thr 
145                 150                 155                 160 


Gln Ile Ala Gly Leu Asn Cys Leu Arg Leu Met Asn Glu Thr Thr Ala 
                165                 170                 175     


Val Ala Leu Ala Tyr Gly Ile Tyr Lys Gln Asp Leu Pro Ala Leu Glu 
            180                 185                 190         


Glu Lys Pro Arg Asn Val Val Phe Val Asp Met Gly His Ser Ala Tyr 
        195                 200                 205             


Gln Val Ser Val Cys Ala Phe Asn Arg Gly Lys Leu Lys Val Leu Ala 
    210                 215                 220                 


Thr Ala Phe Asp Thr Thr Leu Gly Gly Arg Lys Phe Asp Glu Val Leu 
225                 230                 235                 240 


Val Asn His Phe Cys Glu Glu Phe Gly Lys Lys Tyr Lys Leu Asp Ile 
                245                 250                 255     


Lys Ser Lys Ile Arg Ala Leu Leu Arg Leu Ser Gln Glu Cys Glu Lys 
            260                 265                 270         


Leu Lys Lys Leu Met Ser Ala Asn Ala Ser Asp Leu Pro Leu Ser Ile 
        275                 280                 285             


Glu Cys Phe Met Asn Asp Val Asp Val Ser Gly Thr Met Asn Arg Gly 
    290                 295                 300                 


Lys Phe Leu Glu Met Cys Asn Asp Leu Leu Ala Arg Val Glu Pro Pro 
305                 310                 315                 320 


Leu Arg Ser Val Leu Glu Gln Thr Lys Leu Lys Lys Glu Asp Ile Tyr 
                325                 330                 335     


Ala Val Glu Ile Val Gly Gly Ala Thr Arg Ile Pro Ala Val Lys Glu 
            340                 345                 350         


Lys Ile Ser Lys Phe Phe Gly Lys Glu Leu Ser Thr Thr Leu Asn Ala 
        355                 360                 365             


Asp Glu Ala Val Thr Arg Gly Cys Ala Leu Gln Cys Ala Ile Leu Ser 
    370                 375                 380                 


Pro Ala Phe Lys Val Arg Glu Phe Ser Ile Thr Asp Val Val Pro Tyr 
385                 390                 395                 400 


Pro Ile Ser Leu Arg Trp Asn Ser Pro Ala Glu Glu Gly Ser Ser Asp 
                405                 410                 415     


Cys Glu Val Phe Ser Lys Asn His Ala Ala Pro Phe Ser Lys Val Leu 
            420                 425                 430         


Thr Phe Tyr Arg Lys Glu Pro Phe Thr Leu Glu Ala Tyr Tyr Ser Ser 
        435                 440                 445             


Pro Gln Asp Leu Pro Tyr Pro Asp Pro Ala Ile Ala Gln Phe Ser Val 
    450                 455                 460                 


Gln Lys Val Thr Pro Gln Ser Asp Gly Ser Ser Ser Lys Val Lys Val 
465                 470                 475                 480 


Lys Val Arg Val Asn Val His Gly Ile Phe Ser Val Ser Ser Ala Ser 
                485                 490                 495     


Leu Val Glu Val His Lys Ser Glu Glu Asn Glu Glu Pro Met Glu Thr 
            500                 505                 510         


Asp Gln Asn Ala Lys Glu Glu Glu Lys Met Gln Val Asp Gln Glu Glu 
        515                 520                 525             


Pro His Val Glu Glu Gln Gln Gln Gln Thr Pro Ala Glu Asn Lys Ala 
    530                 535                 540                 


Glu Ser Glu Glu Met Glu Thr Ser Gln Ala Gly Ser Lys Asp Lys Lys 
545                 550                 555                 560 


Met Asp Gln Pro Pro Gln Ala Lys Lys Ala Lys Val Lys Thr Ser Thr 
                565                 570                 575     


Val Asp Leu Pro Ile Glu Asn Gln Leu Leu Trp Gln Ile Asp Arg Glu 
            580                 585                 590         


Met Leu Asn Leu Tyr Ile Glu Asn Glu Gly Lys Met Ile Met Gln Asp 
        595                 600                 605             


Lys Leu Glu Lys Glu Arg Asn Asp Ala Lys Asn Ala Val Glu Glu Tyr 
    610                 615                 620                 


Val Tyr Glu Met Arg Asp Lys Leu Ser Gly Glu Tyr Glu Lys Phe Val 
625                 630                 635                 640 


Ser Glu Asp Asp Arg Asn Ser Phe Thr Leu Lys Leu Glu Asp Thr Glu 
                645                 650                 655     


Asn Trp Leu Tyr Glu Asp Gly Glu Asp Gln Pro Lys Gln Val Tyr Val 
            660                 665                 670         


Asp Lys Leu Ala Glu Leu Lys Asn Leu Gly Gln Pro Ile Lys Ile Arg 
        675                 680                 685             


Phe Gln Glu Ser Glu Glu Arg Pro Lys Leu Phe Glu Glu Leu Gly Lys 
    690                 695                 700                 


Gln Ile Gln Gln Tyr Met Lys Ile Ile Ser Ser Phe Lys Asn Lys Glu 
705                 710                 715                 720 


Asp Gln Tyr Asp His Leu Asp Ala Ala Asp Met Thr Lys Val Glu Lys 
                725                 730                 735     


Ser Thr Asn Glu Ala Met Glu Trp Met Asn Asn Lys Leu Asn Leu Gln 
            740                 745                 750         


Asn Lys Gln Ser Leu Thr Met Asp Pro Val Val Lys Ser Lys Glu Ile 
        755                 760                 765             


Glu Ala Lys Ile Lys Glu Leu Thr Ser Thr Cys Ser Pro Ile Ile Ser 
    770                 775                 780                 


Lys Pro Lys Pro Lys Val Glu Pro Pro Lys Glu Glu Gln Lys Asn Ala 
785                 790                 795                 800 


Glu Gln Asn Gly Pro Val Asp Gly Gln Gly Asp Asn Pro Gly Pro Gln 
                805                 810                 815     


Ala Ala Glu Gln Gly Thr Asp Thr Ala Val Pro Ser Asp Ser Asp Lys 
            820                 825                 830         


Lys Leu Pro Glu Met Asp Ile Asp 
        835                 840 


<210>  250
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Lys Ala Leu Ser Pro Val Arg Gly Cys Tyr Glu Ala Val Cys Cys 
1               5                   10                  15      


Leu Ser Glu Arg Ser Leu Ala Ile Ala Arg Gly Arg Gly Lys Gly Pro 
            20                  25                  30          


Ala Ala Glu Glu Pro Leu Ser Leu Leu Asp Asp Met Asn His Cys Tyr 
        35                  40                  45              


Ser Arg Leu Arg Glu Leu Val Pro Gly Val Pro Arg Gly Thr Gln Leu 
    50                  55                  60                  


Ser Gln Val Glu Ile Leu Gln Arg Val Ile Asp Tyr Ile Leu Asp Leu 
65                  70                  75                  80  


Gln Val Val Leu Ala Glu Pro Ala Pro Gly Pro Pro Asp Gly Pro His 
                85                  90                  95      


Leu Pro Ile Gln Thr Ala Glu Leu Thr Pro Glu Leu Val Ile Ser Asn 
            100                 105                 110         


Asp Lys Arg Ser Phe Cys His 
        115                 


<210>  251
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  251

Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe Lys 
            180                 185                 190         


Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg Gln 
        195                 200                 205             


Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu Ala 
    210                 215                 220                 


Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg Tyr 
                245                 250                 255     


Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu 
            260                 265                 270         


Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu His 
        275                 280                 285             


His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys Glu 
    290                 295                 300                 


Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp Lys 
305                 310                 315                 320 


Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys Lys 
                325                 330                 335     


Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile Glu 
            340                 345                 350         


Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu Cys 
        355                 360                 365             


Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His Tyr 
    370                 375                 380                 


Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile Ile 
385                 390                 395                 400 


His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg Asp 
                405                 410                 415     


Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg Arg 
            420                 425                 430         


Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr Lys 
        435                 440                 445             


Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala Leu 
    450                 455                 460                 


Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
465                 470                 475             


<210>  252
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Arg Pro Thr Leu Leu Trp Ser Leu Leu Leu Leu Leu Gly Val Phe 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Pro Pro Asp Pro Leu Ser Gln Leu Pro Ala 
            20                  25                  30          


Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser 
        35                  40                  45              


Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg Pro Val Val Tyr Gln 
    50                  55                  60                  


Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe Thr Ala Asp Ile Met 
65                  70                  75                  80  


Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala Thr Glu Cys Asp Phe 
                85                  90                  95      


Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met Asp Phe Asn Val Thr 
            100                 105                 110         


Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His Ser Ala Trp Val Thr 
        115                 120                 125             


Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr Val Gly Pro Pro Glu 
    130                 135                 140                 


Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu Ile Ile Arg Phe Ser 
145                 150                 155                 160 


Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala Phe Phe Cys Tyr Tyr 
                165                 170                 175     


Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln Val Lys Gly Pro Phe 
            180                 185                 190         


Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys Pro Ser Arg Val Tyr 
        195                 200                 205             


Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn Lys Ser Asn Ile Phe 
    210                 215                 220                 


Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr Glu Thr Met Ala Asp 
225                 230                 235                 240 


Ala Ser Thr Glu Leu Gln Gln Val Ile Leu Ile Ser Val Gly Thr Phe 
                245                 250                 255     


Ser Leu Leu Ser Val Leu Ala Gly Ala Cys Phe Phe Leu Val Leu Lys 
            260                 265                 270         


Tyr Arg Gly Leu Ile Lys Tyr Trp Phe His Thr Pro Pro Ser Ile Pro 
        275                 280                 285             


Leu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu 
    290                 295                 300                 


Ala Leu Asp Lys Asp Ser Ser Pro Lys Asp Asp Val Trp Asp Ser Val 
305                 310                 315                 320 


Ser Ile Ile Ser Phe Pro Glu Lys Glu Gln Glu Asp Val Leu Gln Thr 
                325                 330                 335     


Leu 
    


<210>  253
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  254
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  254

Met Val Arg Lys Leu Lys Phe His Glu Gln Lys Leu Leu Lys Gln Val 
1               5                   10                  15      


Asp Phe Leu Asn Trp Glu Val Thr Asp His Asn Leu His Glu Leu Arg 
            20                  25                  30          


Val Leu Arg Arg Tyr Arg Leu Gln Arg Arg Glu Asp Tyr Thr Arg Tyr 
        35                  40                  45              


Asn Gln Leu Ser Arg Ala Val Arg Glu Leu Ala Arg Arg Leu Arg Asp 
    50                  55                  60                  


Leu Pro Glu Arg Asp Gln Phe Arg Val Arg Ala Ser Ala Ala Leu Leu 
65                  70                  75                  80  


Asp Lys Leu Tyr Ala Leu Gly Leu Val Pro Thr Arg Gly Ser Leu Glu 
                85                  90                  95      


Leu Cys Asp Phe Val Thr Ala Ser Ser Phe Cys Arg Arg Arg Leu Pro 
            100                 105                 110         


Thr Val Leu Leu Lys Leu Arg Met Ala Gln His Leu Gln Ala Ala Val 
        115                 120                 125             


Ala Phe Val Glu Gln Gly His Val Arg Val Gly Pro Asp Val Val Thr 
    130                 135                 140                 


Asp Pro Ala Phe Leu Val Thr Arg Ser Met Glu Asp Phe Val Thr Trp 
145                 150                 155                 160 


Val Asp Ser Ser Lys Ile Lys Arg His Val Leu Glu Tyr Asn Glu Glu 
                165                 170                 175     


Arg Asp Asp Phe Asp Leu Glu Ala 
            180                 


<210>  255
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Pro Arg Leu Asp Leu Ala Thr His Pro Thr Thr Pro Arg Ser Glu 
    50                  55                  60                  


Leu Ser Ser Val Val Leu Leu Ala Gly Val Gly Val Gln Met Asp Arg 
65                  70                  75                  80  


Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly 
                85                  90                  95      


Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala 
            100                 105                 110         


Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp 
        115                 120                 125             


Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile 
    130                 135                 140                 


Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu 
145                 150                 155                 160 


Ala Asp Met Ala Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile 
                165                 170                 175     


His His Asn Cys Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val 
            180                 185                 190         


Lys Lys Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro 
        195                 200                 205             


Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe 
    210                 215                 220                 


Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val 
225                 230                 235                 240 


Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His 
                245                 250                 255     


Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val 
            260                 265                 270         


Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg 
        275                 280                 285             


Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val 
    290                 295                 300                 


Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu 
305                 310                 315                 320 


Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly 
                325                 330                 335     


Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly 
            340                 345                 350         


Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln 
        355                 360                 365             


Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val 
    370                 375                 380                 


Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp 
385                 390                 395                 400 


Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys 
                405                 410                 415     


Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val 
            420                 425                 430         


Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala 
        435                 440                 445             


Asp Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu 
    450                 455                 460                 


Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu 
465                 470                 475                 480 


Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr 
                485                 490                 495     


Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln 
            500                 505                 510         


Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val 
        515                 520                 525             


Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr 
    530                 535                 540                 


Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser 
545                 550                 555                 560 


Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu 
                565                 570                 575     


Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His 
            580                 585                 590         


Ser Tyr Glu Lys Arg Leu Tyr 
        595                 


<210>  256
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  256

Met Ser Asp Ile Leu Arg Glu Leu Leu Cys Val Ser Glu Lys Ala Ala 
1               5                   10                  15      


Asn Ile Ala Arg Ala Cys Arg Gln Gln Glu Ala Leu Phe Gln Leu Leu 
            20                  25                  30          


Ile Glu Glu Lys Lys Glu Gly Glu Lys Asn Lys Lys Phe Ala Val Asp 
        35                  40                  45              


Phe Lys Thr Leu Ala Asp Val Leu Val Gln Glu Val Ile Lys Gln Asn 
    50                  55                  60                  


Met Glu Asn Lys Phe Pro Gly Leu Glu Lys Asn Ile Phe Gly Glu Glu 
65                  70                  75                  80  


Ser Asn Glu Phe Thr Asn Asp Trp Gly Glu Lys Ile Thr Leu Arg Leu 
                85                  90                  95      


Cys Ser Thr Glu Glu Glu Thr Ala Glu Leu Leu Ser Lys Val Leu Asn 
            100                 105                 110         


Gly Asn Lys Val Ala Ser Glu Ala Leu Ala Arg Val Val His Gln Asp 
        115                 120                 125             


Val Ala Phe Thr Asp Pro Thr Leu Asp Ser Thr Glu Ile Asn Val Pro 
    130                 135                 140                 


Gln Asp Ile Leu Gly Ile Trp Val Asp Pro Ile Asp Ser Thr Tyr Gln 
145                 150                 155                 160 


Tyr Ile Lys Gly Ser Ala Asp Ile Lys Ser Asn Gln Gly Ile Phe Pro 
                165                 170                 175     


Cys Gly Leu Gln Cys Val Thr Ile Leu Ile Gly Val Tyr Asp Ile Gln 
            180                 185                 190         


Thr Gly Val Pro Leu Met Gly Val Ile Asn Gln Pro Phe Val Ser Arg 
        195                 200                 205             


Asp Pro Asn Thr Leu Arg Trp Lys Gly Gln Cys Tyr Trp Gly Leu Ser 
    210                 215                 220                 


Tyr Met Gly Thr Asn Met His Ser Leu Gln Leu Thr Ile Ser Arg Arg 
225                 230                 235                 240 


Asn Gly Ser Glu Thr His Thr Gly Asn Thr Gly Ser Glu Ala Ala Phe 
                245                 250                 255     


Ser Pro Ser Phe Ser Ala Val Ile Ser Thr Ser Glu Lys Glu Thr Ile 
            260                 265                 270         


Lys Ala Ala Leu Ser Arg Val Cys Gly Asp Arg Ile Phe Gly Ala Ala 
        275                 280                 285             


Gly Ala Gly Tyr Lys Ser Leu Cys Val Val Gln Gly Leu Val Asp Ile 
    290                 295                 300                 


Tyr Ile Phe Ser Glu Asp Thr Thr Phe Lys Trp Asp Ser Cys Ala Ala 
305                 310                 315                 320 


His Ala Ile Leu Arg Ala Met Gly Gly Gly Ile Val Asp Leu Lys Glu 
                325                 330                 335     


Cys Leu Glu Arg Asn Pro Glu Thr Gly Leu Asp Leu Pro Gln Leu Val 
            340                 345                 350         


Tyr His Val Glu Asn Glu Gly Ala Ala Gly Val Asp Arg Trp Ala Asn 
        355                 360                 365             


Lys Gly Gly Leu Ile Ala Tyr Arg Ser Arg Lys Arg Leu Glu Thr Phe 
    370                 375                 380                 


Leu Ser Leu Leu Val Gln Asn Leu Ala Pro Ala Glu Thr His Thr 
385                 390                 395                 


<210>  257
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Ala Gly Ser Arg Glu Val Val Ala Met Asp Cys Glu Met Val Gly 
1               5                   10                  15      


Leu Gly Pro His Arg Glu Ser Gly Leu Ala Arg Cys Ser Leu Val Asn 
            20                  25                  30          


Val His Gly Ala Val Leu Tyr Asp Lys Phe Ile Arg Pro Glu Gly Glu 
        35                  40                  45              


Ile Thr Asp Tyr Arg Thr Arg Val Ser Gly Val Thr Pro Gln His Met 
    50                  55                  60                  


Val Gly Ala Thr Pro Phe Ala Val Ala Arg Leu Glu Ile Leu Gln Leu 
65                  70                  75                  80  


Leu Lys Gly Lys Leu Val Val Gly His Asp Leu Lys His Asp Phe Gln 
                85                  90                  95      


Ala Leu Lys Glu Asp Met Ser Gly Tyr Thr Ile Tyr Asp Thr Ser Thr 
            100                 105                 110         


Asp Arg Leu Leu Trp Arg Glu Ala Lys Leu Asp His Cys Arg Arg Val 
        115                 120                 125             


Ser Leu Arg Val Leu Ser Glu Arg Leu Leu His Lys Ser Ile Gln Asn 
    130                 135                 140                 


Ser Leu Leu Gly His Ser Ser Val Glu Asp Ala Arg Ala Thr Met Glu 
145                 150                 155                 160 


Leu Tyr Gln Ile Ser Gln Arg Ile Arg Ala Arg Arg Gly Leu Pro Arg 
                165                 170                 175     


Leu Ala Val Ser Asp 
            180     


<210>  258
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  258

Met Thr Arg Thr Arg Ala Ala Leu Leu Leu Phe Thr Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Gly Phe Asn Leu Asp Thr Glu Glu Leu Thr Ala Phe Arg Val 
            20                  25                  30          


Asp Ser Ala Gly Phe Gly Asp Ser Val Val Gln Tyr Ala Asn Ser Trp 
        35                  40                  45              


Val Val Val Gly Ala Pro Gln Lys Ile Thr Ala Ala Asn Gln Thr Gly 
    50                  55                  60                  


Gly Leu Tyr Gln Cys Gly Tyr Ser Thr Gly Ala Cys Glu Pro Ile Gly 
65                  70                  75                  80  


Leu Gln Val Pro Pro Glu Ala Val Asn Met Ser Leu Gly Leu Ser Leu 
                85                  90                  95      


Ala Ser Thr Thr Ser Pro Ser Gln Leu Leu Ala Cys Gly Pro Thr Val 
            100                 105                 110         


His His Glu Cys Gly Arg Asn Met Tyr Leu Thr Gly Leu Cys Phe Leu 
        115                 120                 125             


Leu Gly Pro Thr Gln Leu Thr Gln Arg Leu Pro Val Ser Arg Gln Glu 
    130                 135                 140                 


Cys Pro Arg Gln Glu Gln Asp Ile Val Phe Leu Ile Asp Gly Ser Gly 
145                 150                 155                 160 


Ser Ile Ser Ser Arg Asn Phe Ala Thr Met Met Asn Phe Val Arg Ala 
                165                 170                 175     


Val Ile Ser Gln Phe Gln Arg Pro Ser Thr Gln Phe Ser Leu Met Gln 
            180                 185                 190         


Phe Ser Asn Lys Phe Gln Thr His Phe Thr Phe Glu Glu Phe Arg Arg 
        195                 200                 205             


Ser Ser Asn Pro Leu Ser Leu Leu Ala Ser Val His Gln Leu Gln Gly 
    210                 215                 220                 


Phe Thr Tyr Thr Ala Thr Ala Ile Gln Asn Val Val His Arg Leu Phe 
225                 230                 235                 240 


His Ala Ser Tyr Gly Ala Arg Arg Asp Ala Ala Lys Ile Leu Ile Val 
                245                 250                 255     


Ile Thr Asp Gly Lys Lys Glu Gly Asp Ser Leu Asp Tyr Lys Asp Val 
            260                 265                 270         


Ile Pro Met Ala Asp Ala Ala Gly Ile Ile Arg Tyr Ala Ile Gly Val 
        275                 280                 285             


Gly Leu Ala Phe Gln Asn Arg Asn Ser Trp Lys Glu Leu Asn Asp Ile 
    290                 295                 300                 


Ala Ser Lys Pro Ser Gln Glu His Ile Phe Lys Val Glu Asp Phe Asp 
305                 310                 315                 320 


Ala Leu Lys Asp Ile Gln Asn Gln Leu Lys Glu Lys Ile Phe Ala Ile 
                325                 330                 335     


Glu Gly Thr Glu Thr Thr Ser Ser Ser Ser Phe Glu Leu Glu Met Ala 
            340                 345                 350         


Gln Glu Gly Phe Ser Ala Val Phe Thr Pro Asp Gly Pro Val Leu Gly 
        355                 360                 365             


Ala Val Gly Ser Phe Thr Trp Ser Gly Gly Ala Phe Leu Tyr Pro Pro 
    370                 375                 380                 


Asn Met Ser Pro Thr Phe Ile Asn Met Ser Gln Glu Asn Val Asp Met 
385                 390                 395                 400 


Arg Asp Ser Tyr Leu Gly Tyr Ser Thr Glu Leu Ala Leu Trp Lys Gly 
                405                 410                 415     


Val Gln Ser Leu Val Leu Gly Ala Pro Arg Tyr Gln His Thr Gly Lys 
            420                 425                 430         


Ala Val Ile Phe Thr Gln Val Ser Arg Gln Trp Arg Met Lys Ala Glu 
        435                 440                 445             


Val Thr Gly Thr Gln Ile Gly Ser Tyr Phe Gly Ala Ser Leu Cys Ser 
    450                 455                 460                 


Val Asp Val Asp Ser Asp Gly Ser Thr Asp Leu Val Leu Ile Gly Ala 
465                 470                 475                 480 


Pro His Tyr Tyr Glu Gln Thr Arg Gly Gly Gln Val Ser Val Cys Pro 
                485                 490                 495     


Leu Pro Arg Gly Trp Arg Arg Trp Trp Cys Asp Ala Val Leu Tyr Gly 
            500                 505                 510         


Glu Gln Gly His Pro Trp Gly Arg Phe Gly Ala Ala Leu Thr Val Leu 
        515                 520                 525             


Gly Asp Val Asn Gly Asp Lys Leu Thr Asp Val Val Ile Gly Ala Pro 
    530                 535                 540                 


Gly Glu Glu Glu Asn Arg Gly Ala Val Tyr Leu Phe His Gly Val Leu 
545                 550                 555                 560 


Gly Pro Ser Ile Ser Pro Ser His Ser Gln Arg Ile Ala Gly Ser Gln 
                565                 570                 575     


Leu Ser Ser Arg Leu Gln Tyr Phe Gly Gln Ala Leu Ser Gly Gly Gln 
            580                 585                 590         


Asp Leu Thr Gln Asp Gly Leu Val Asp Leu Ala Val Gly Ala Arg Gly 
        595                 600                 605             


Gln Val Leu Leu Leu Arg Thr Arg Pro Val Leu Trp Val Gly Val Ser 
    610                 615                 620                 


Met Gln Phe Ile Pro Ala Glu Ile Pro Arg Ser Ala Phe Glu Cys Arg 
625                 630                 635                 640 


Glu Gln Val Val Ser Glu Gln Thr Leu Val Gln Ser Asn Ile Cys Leu 
                645                 650                 655     


Tyr Ile Asp Lys Arg Ser Lys Asn Leu Leu Gly Ser Arg Asp Leu Gln 
            660                 665                 670         


Ser Ser Val Thr Leu Asp Leu Ala Leu Asp Pro Gly Arg Leu Ser Pro 
        675                 680                 685             


Arg Ala Thr Phe Gln Glu Thr Lys Asn Arg Ser Leu Ser Arg Val Arg 
    690                 695                 700                 


Val Leu Gly Leu Lys Ala His Cys Glu Asn Phe Asn Leu Leu Leu Pro 
705                 710                 715                 720 


Ser Cys Val Glu Asp Ser Val Thr Pro Ile Thr Leu Arg Leu Asn Phe 
                725                 730                 735     


Thr Leu Val Gly Lys Pro Leu Leu Ala Phe Arg Asn Leu Arg Pro Met 
            740                 745                 750         


Leu Ala Ala Asp Ala Gln Arg Tyr Phe Thr Ala Ser Leu Pro Phe Glu 
        755                 760                 765             


Lys Asn Cys Gly Ala Asp His Ile Cys Gln Asp Asn Leu Gly Ile Ser 
    770                 775                 780                 


Phe Ser Phe Pro Gly Leu Lys Ser Leu Leu Val Gly Ser Asn Leu Glu 
785                 790                 795                 800 


Leu Asn Ala Glu Val Met Val Trp Asn Asp Gly Glu Asp Ser Tyr Gly 
                805                 810                 815     


Thr Thr Ile Thr Phe Ser His Pro Ala Gly Leu Ser Tyr Arg Tyr Val 
            820                 825                 830         


Ala Glu Gly Gln Lys Gln Gly Gln Leu Arg Ser Leu His Leu Thr Cys 
        835                 840                 845             


Asp Ser Ala Pro Val Gly Ser Gln Gly Thr Trp Ser Thr Ser Cys Arg 
    850                 855                 860                 


Ile Asn His Leu Ile Phe Arg Gly Gly Ala Gln Ile Thr Phe Leu Ala 
865                 870                 875                 880 


Thr Phe Asp Val Ser Pro Lys Ala Val Leu Gly Asp Arg Leu Leu Leu 
                885                 890                 895     


Thr Ala Asn Val Ser Ser Glu Asn Asn Thr Pro Arg Thr Ser Lys Thr 
            900                 905                 910         


Thr Phe Gln Leu Glu Leu Pro Val Lys Tyr Ala Val Tyr Thr Val Val 
        915                 920                 925             


Ser Ser His Glu Gln Phe Thr Lys Tyr Leu Asn Phe Ser Glu Ser Glu 
    930                 935                 940                 


Glu Lys Glu Ser His Val Ala Met His Arg Tyr Gln Val Asn Asn Leu 
945                 950                 955                 960 


Gly Gln Arg Asp Leu Pro Val Ser Ile Asn Phe Trp Val Pro Val Glu 
                965                 970                 975     


Leu Asn Gln Glu Ala Val Trp Met Asp Val Glu Val Ser His Pro Gln 
            980                 985                 990         


Asn Pro Ser Leu Arg Cys Ser Ser  Glu Lys Ile Ala Pro  Pro Ala Ser 
        995                 1000                 1005             


Asp Phe  Leu Ala His Ile Gln  Lys Asn Pro Val Leu  Asp Cys Ser 
    1010                 1015                 1020             


Ile Ala  Gly Cys Leu Arg Phe  Arg Cys Asp Val Pro  Ser Phe Ser 
    1025                 1030                 1035             


Val Gln  Glu Glu Leu Asp Phe  Thr Leu Lys Gly Asn  Leu Ser Phe 
    1040                 1045                 1050             


Gly Trp  Val Arg Gln Ile Leu  Gln Lys Lys Val Ser  Val Val Ser 
    1055                 1060                 1065             


Val Ala  Glu Ile Thr Phe Asp  Thr Ser Val Tyr Ser  Gln Leu Pro 
    1070                 1075                 1080             


Gly Gln  Glu Ala Phe Met Arg  Ala Gln Thr Thr Thr  Val Leu Glu 
    1085                 1090                 1095             


Lys Tyr  Lys Val His Asn Pro  Thr Pro Leu Ile Val  Gly Ser Ser 
    1100                 1105                 1110             


Ile Gly  Gly Leu Leu Leu Leu  Ala Leu Ile Thr Ala  Val Leu Tyr 
    1115                 1120                 1125             


Lys Val  Gly Phe Phe Lys Arg  Gln Tyr Lys Glu Met  Met Glu Glu 
    1130                 1135                 1140             


Ala Asn  Gly Gln Ile Ala Pro  Glu Asn Gly Thr Gln  Thr Pro Ser 
    1145                 1150                 1155             


Pro Pro  Ser Glu Lys 
    1160             


<210>  259
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  259

Met Asn Leu Gln Pro Ile Phe Trp Ile Gly Leu Ile Ser Ser Val Cys 
1               5                   10                  15      


Cys Val Phe Ala Gln Thr Asp Glu Asn Arg Cys Leu Lys Ala Asn Ala 
            20                  25                  30          


Lys Ser Cys Gly Glu Cys Ile Gln Ala Gly Pro Asn Cys Gly Trp Cys 
        35                  40                  45              


Thr Asn Ser Thr Phe Leu Gln Glu Gly Met Pro Thr Ser Ala Arg Cys 
    50                  55                  60                  


Asp Asp Leu Glu Ala Leu Lys Lys Lys Gly Cys Pro Pro Asp Asp Ile 
65                  70                  75                  80  


Glu Asn Pro Arg Gly Ser Lys Asp Ile Lys Lys Asn Lys Asn Val Thr 
                85                  90                  95      


Asn Arg Ser Lys Gly Thr Ala Glu Lys Leu Lys Pro Glu Asp Ile Thr 
            100                 105                 110         


Gln Ile Gln Pro Gln Gln Leu Val Leu Arg Leu Arg Ser Gly Glu Pro 
        115                 120                 125             


Gln Thr Phe Thr Leu Lys Phe Lys Arg Ala Glu Asp Tyr Pro Ile Asp 
    130                 135                 140                 


Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu Glu 
145                 150                 155                 160 


Asn Val Lys Ser Leu Gly Thr Asp Leu Met Asn Glu Met Arg Arg Ile 
                165                 170                 175     


Thr Ser Asp Phe Arg Ile Gly Phe Gly Ser Phe Val Glu Lys Thr Val 
            180                 185                 190         


Met Pro Tyr Ile Ser Thr Thr Pro Ala Lys Leu Arg Asn Pro Cys Thr 
        195                 200                 205             


Ser Glu Gln Asn Cys Thr Ser Pro Phe Ser Tyr Lys Asn Val Leu Ser 
    210                 215                 220                 


Leu Thr Asn Lys Gly Glu Val Phe Asn Glu Leu Val Gly Lys Gln Arg 
225                 230                 235                 240 


Ile Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp Ala Ile Met 
                245                 250                 255     


Gln Val Ala Val Cys Gly Ser Leu Ile Gly Trp Arg Asn Val Thr Arg 
            260                 265                 270         


Leu Leu Val Phe Ser Thr Asp Ala Gly Phe His Phe Ala Gly Asp Gly 
        275                 280                 285             


Lys Leu Gly Gly Ile Val Leu Pro Asn Asp Gly Gln Cys His Leu Glu 
    290                 295                 300                 


Asn Asn Met Tyr Thr Met Ser His Tyr Tyr Asp Tyr Pro Ser Ile Ala 
305                 310                 315                 320 


His Leu Val Gln Lys Leu Ser Glu Asn Asn Ile Gln Thr Ile Phe Ala 
                325                 330                 335     


Val Thr Glu Glu Phe Gln Pro Val Tyr Lys Glu Leu Lys Asn Leu Ile 
            340                 345                 350         


Pro Lys Ser Ala Val Gly Thr Leu Ser Ala Asn Ser Ser Asn Val Ile 
        355                 360                 365             


Gln Leu Ile Ile Asp Ala Tyr Asn Ser Leu Ser Ser Glu Val Ile Leu 
    370                 375                 380                 


Glu Asn Gly Lys Leu Ser Glu Gly Val Thr Ile Ser Tyr Lys Ser Tyr 
385                 390                 395                 400 


Cys Lys Asn Gly Val Asn Gly Thr Gly Glu Asn Gly Arg Lys Cys Ser 
                405                 410                 415     


Asn Ile Ser Ile Gly Asp Glu Val Gln Phe Glu Ile Ser Ile Thr Ser 
            420                 425                 430         


Asn Lys Cys Pro Lys Lys Asp Ser Asp Ser Phe Lys Ile Arg Pro Leu 
        435                 440                 445             


Gly Phe Thr Glu Glu Val Glu Val Ile Leu Gln Tyr Ile Cys Glu Cys 
    450                 455                 460                 


Glu Cys Gln Ser Glu Gly Ile Pro Glu Ser Pro Lys Cys His Glu Gly 
465                 470                 475                 480 


Asn Gly Thr Phe Glu Cys Gly Ala Cys Arg Cys Asn Glu Gly Arg Val 
                485                 490                 495     


Gly Arg His Cys Glu Cys Ser Thr Asp Glu Val Asn Ser Glu Asp Met 
            500                 505                 510         


Asp Ala Tyr Cys Arg Lys Glu Asn Ser Ser Glu Ile Cys Ser Asn Asn 
        515                 520                 525             


Gly Glu Cys Val Cys Gly Gln Cys Val Cys Arg Lys Arg Asp Asn Thr 
    530                 535                 540                 


Asn Glu Ile Tyr Ser Gly Lys Phe Cys Glu Cys Asp Asn Phe Asn Cys 
545                 550                 555                 560 


Asp Arg Ser Asn Gly Leu Ile Cys Gly Gly Asn Gly Val Cys Lys Cys 
                565                 570                 575     


Arg Val Cys Glu Cys Asn Pro Asn Tyr Thr Gly Ser Ala Cys Asp Cys 
            580                 585                 590         


Ser Leu Asp Thr Ser Thr Cys Glu Ala Ser Asn Gly Gln Ile Cys Asn 
        595                 600                 605             


Gly Arg Gly Ile Cys Glu Cys Gly Val Cys Lys Cys Thr Asp Pro Lys 
    610                 615                 620                 


Phe Gln Gly Gln Thr Cys Glu Met Cys Gln Thr Cys Leu Gly Val Cys 
625                 630                 635                 640 


Ala Glu His Lys Glu Cys Val Gln Cys Arg Ala Phe Asn Lys Gly Glu 
                645                 650                 655     


Lys Lys Asp Thr Cys Thr Gln Glu Cys Ser Tyr Phe Asn Ile Thr Lys 
            660                 665                 670         


Val Glu Ser Arg Asp Lys Leu Pro Gln Pro Val Gln Pro Asp Pro Val 
        675                 680                 685             


Ser His Cys Lys Glu Lys Asp Val Asp Asp Cys Trp Phe Tyr Phe Thr 
    690                 695                 700                 


Tyr Ser Val Asn Gly Asn Asn Glu Val Met Val His Val Val Glu Asn 
705                 710                 715                 720 


Pro Glu Cys Pro Thr Gly Pro Asp Ile Ile Pro Ile Val Ala Gly Val 
                725                 730                 735     


Val Ala Gly Ile Val Leu Ile Gly Leu Ala Leu Leu Leu Ile Trp Lys 
            740                 745                 750         


Leu Leu Met Ile Ile His Asp Arg Arg Glu Phe Ala Lys Phe Glu Lys 
        755                 760                 765             


Glu Lys Met Asn Ala Lys Trp Asp Thr Gly Glu Asn Pro Ile Tyr Lys 
    770                 775                 780                 


Ser Ala Val Thr Thr Val Val Asn Pro Lys Tyr Glu Gly Lys 
785                 790                 795             


<210>  260
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  260

Met Ser Leu Leu Met Ile Ser Glu Asn Val Lys Leu Ala Arg Glu Tyr 
1               5                   10                  15      


Ala Leu Leu Gly Asn Tyr Asp Ser Ala Met Val Tyr Tyr Gln Gly Val 
            20                  25                  30          


Leu Asp Gln Met Asn Lys Tyr Leu Tyr Ser Val Lys Asp Thr Tyr Leu 
        35                  40                  45              


Gln Gln Lys Trp Gln Gln Val Trp Gln Glu Ile Asn Val Glu Ala Lys 
    50                  55                  60                  


His Val Lys Asp Ile Met Lys Thr Leu Glu Ser Phe Lys Leu Asp Ser 
65                  70                  75                  80  


Thr Pro Leu Lys Ala Ala Gln His Asp Leu Pro Ala Ser Glu Gly Glu 
                85                  90                  95      


Val Trp Ser Met Pro Val Pro Val Glu Arg Arg Pro Ser Pro Gly Pro 
            100                 105                 110         


Arg Lys Arg Gln Ser Ser Gln Tyr Ser Asp Pro Lys Ser His Gly Asn 
        115                 120                 125             


Arg Pro Ser Thr Thr Val Arg Val His Arg Ser Ser Ala Gln Asn Val 
    130                 135                 140                 


His Asn Asp Arg Gly Lys Ala Val Arg Cys Arg Glu Lys Lys Glu Gln 
145                 150                 155                 160 


Asn Lys Gly Arg Glu Glu Lys Asn Lys Ser Pro Ala Ala Val Thr Glu 
                165                 170                 175     


Pro Glu Thr Asn Lys Phe Asp Ser Thr Gly Tyr Asp Lys Asp Leu Val 
            180                 185                 190         


Glu Ala Leu Glu Arg Asp Ile Ile Ser Gln Asn Pro Asn Val Arg Trp 
        195                 200                 205             


Asp Asp Ile Ala Asp Leu Val Glu Ala Lys Lys Leu Leu Lys Glu Ala 
    210                 215                 220                 


Val Val Leu Pro Met Trp Met Pro Glu Phe Phe Lys Gly Ile Arg Arg 
225                 230                 235                 240 


Pro Trp Lys Gly Val Leu Met Val Gly Pro Pro Gly Thr Gly Lys Thr 
                245                 250                 255     


Leu Leu Ala Lys Ala Val Ala Thr Glu Cys Lys Thr Thr Phe Phe Asn 
            260                 265                 270         


Val Ser Ser Ser Thr Leu Thr Ser Lys Tyr Arg Gly Glu Ser Glu Lys 
        275                 280                 285             


Leu Val Arg Leu Leu Phe Glu Met Ala Arg Phe Tyr Ser Pro Ala Thr 
    290                 295                 300                 


Ile Phe Ile Asp Glu Ile Asp Ser Ile Cys Ser Arg Arg Gly Thr Ser 
305                 310                 315                 320 


Glu Glu His Glu Ala Ser Arg Arg Val Lys Ala Glu Leu Leu Val Gln 
                325                 330                 335     


Met Asp Gly Val Gly Gly Thr Ser Glu Asn Asp Asp Pro Ser Lys Met 
            340                 345                 350         


Val Met Val Leu Ala Ala Thr Asn Phe Pro Trp Asp Ile Asp Glu Ala 
        355                 360                 365             


Leu Arg Arg Arg Leu Glu Lys Arg Ile Tyr Ile Pro Leu Pro Ser Ala 
    370                 375                 380                 


Lys Gly Arg Glu Glu Leu Leu Arg Ile Ser Leu Arg Glu Leu Glu Leu 
385                 390                 395                 400 


Ala Asp Asp Val Asp Leu Ala Ser Ile Ala Glu Asn Met Glu Gly Tyr 
                405                 410                 415     


Ser Gly Ala Asp Ile Thr Asn Val Cys Arg Asp Ala Ser Leu Met Ala 
            420                 425                 430         


Met Arg Arg Arg Ile Glu Gly Leu Thr Pro Glu Glu Ile Arg Asn Leu 
        435                 440                 445             


Ser Lys Glu Glu Met His Met Pro Thr Thr Met Glu Asp Phe Glu Met 
    450                 455                 460                 


Ala Leu Lys Lys Val Ser Lys Ser Val Ser Ala Ala Asp Ile Glu Arg 
465                 470                 475                 480 


Tyr Glu Lys Trp Ile Phe Glu Phe Gly Ser Cys 
                485                 490     


<210>  261
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  261

Met Ala Leu Ser Glu Pro Ile Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Pro Cys Arg Glu Arg Gly Leu Gln Glu Arg Trp Pro Arg Ala Glu Pro 
            20                  25                  30          


Glu Ser Gly Gly Thr Asp Asp Asp Leu Asn Ser Val Leu Asp Phe Ile 
        35                  40                  45              


Leu Ser Met Gly Leu Asp Gly Leu Gly Ala Glu Ala Ala Pro Glu Pro 
    50                  55                  60                  


Pro Pro Pro Pro Pro Pro Pro Ala Phe Tyr Tyr Pro Glu Pro Gly Ala 
65                  70                  75                  80  


Pro Pro Pro Tyr Ser Ala Pro Ala Gly Gly Leu Val Ser Glu Leu Leu 
                85                  90                  95      


Arg Pro Glu Leu Asp Ala Pro Leu Gly Pro Ala Leu His Gly Arg Phe 
            100                 105                 110         


Leu Leu Ala Pro Pro Gly Arg Leu Val Lys Ala Glu Pro Pro Glu Ala 
        115                 120                 125             


Asp Gly Gly Gly Gly Tyr Gly Cys Ala Pro Gly Leu Thr Arg Gly Pro 
    130                 135                 140                 


Arg Gly Leu Lys Arg Glu Gly Ala Pro Gly Pro Ala Ala Ser Cys Met 
145                 150                 155                 160 


Arg Gly Pro Gly Gly Arg Pro Pro Pro Pro Pro Asp Thr Pro Pro Leu 
                165                 170                 175     


Ser Pro Asp Gly Pro Ala Arg Leu Pro Ala Pro Gly Pro Arg Ala Ser 
            180                 185                 190         


Phe Pro Pro Pro Phe Gly Gly Pro Gly Phe Gly Ala Pro Gly Pro Gly 
        195                 200                 205             


Leu His Tyr Ala Pro Pro Ala Pro Pro Ala Phe Gly Leu Phe Asp Asp 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Leu Gly Leu Ala Pro Pro Ala Ala Arg 
225                 230                 235                 240 


Gly Leu Leu Thr Pro Pro Ala Ser Pro Leu Glu Leu Leu Glu Ala Lys 
                245                 250                 255     


Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His 
            260                 265                 270         


Thr Cys Ser Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His 
        275                 280                 285             


Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys 
    290                 295                 300                 


Asn Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr 
305                 310                 315                 320 


Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln Cys His Leu 
                325                 330                 335     


Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys 
            340                 345                 350         


Arg His Met 
        355 


<210>  262
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Gln Asp Glu Glu Arg Tyr Met Thr Leu Asn Val Gln Ser Lys Lys 
1               5                   10                  15      


Arg Ser Ser Ala Gln Thr Ser Gln Leu Thr Phe Lys Asp Tyr Ser Val 
            20                  25                  30          


Thr Leu His Trp Tyr Lys Ile Leu Leu Gly Ile Ser Gly Thr Val Asn 
        35                  40                  45              


Gly Ile Leu Thr Leu Thr Leu Ile Ser Leu Ile Leu Leu Val Ser Gln 
    50                  55                  60                  


Gly Val Leu Leu Lys Cys Gln Lys Gly Ser Cys Ser Asn Ala Thr Gln 
65                  70                  75                  80  


Tyr Glu Asp Thr Gly Asp Leu Lys Val Asn Asn Gly Thr Arg Arg Asn 
                85                  90                  95      


Ile Ser Asn Lys Asp Leu Cys Ala Ser Arg Ser Ala Asp Gln Thr Val 
            100                 105                 110         


Leu Cys Gln Ser Glu Trp Leu Lys Tyr Gln Gly Lys Cys Tyr Trp Phe 
        115                 120                 125             


Ser Asn Glu Met Lys Ser Trp Ser Asp Ser Tyr Val Tyr Cys Leu Glu 
    130                 135                 140                 


Arg Lys Ser His Leu Leu Ile Ile His Asp Gln Leu Glu Met Ala Phe 
145                 150                 155                 160 


Ile Gln Lys Asn Leu Arg Gln Leu Asn Tyr Val Trp Ile Gly Leu Asn 
                165                 170                 175     


Phe Thr Ser Leu Lys Met Thr Trp Thr Trp Val Asp Gly Ser Pro Ile 
            180                 185                 190         


Asp Ser Lys Ile Phe Phe Ile Lys Gly Pro Ala Lys Glu Asn Ser Cys 
        195                 200                 205             


Ala Ala Ile Lys Glu Ser Lys Ile Phe Ser Glu Thr Cys Ser Ser Val 
    210                 215                 220                 


Phe Lys Trp Ile Cys Gln Tyr 
225                 230     


<210>  263
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala Met Phe Met 
            20                  25                  30          


Val Lys Asn Gly Asn Gly Thr Ala Cys Ile Met Ala Asn Phe Ser Ala 
        35                  40                  45              


Ala Phe Ser Val Asn Tyr Asp Thr Lys Ser Gly Pro Lys Asn Met Thr 
    50                  55                  60                  


Phe Asp Leu Pro Ser Asp Ala Thr Val Val Leu Asn Arg Ser Ser Cys 
65                  70                  75                  80  


Gly Lys Glu Asn Thr Ser Asp Pro Ser Leu Val Ile Ala Phe Gly Arg 
                85                  90                  95      


Gly His Thr Leu Thr Leu Asn Phe Thr Arg Asn Ala Thr Arg Tyr Ser 
            100                 105                 110         


Val Gln Leu Met Ser Phe Val Tyr Asn Leu Ser Asp Thr His Leu Phe 
        115                 120                 125             


Pro Asn Ala Ser Ser Lys Glu Ile Lys Thr Val Glu Ser Ile Thr Asp 
    130                 135                 140                 


Ile Arg Ala Asp Ile Asp Lys Lys Tyr Arg Cys Val Ser Gly Thr Gln 
145                 150                 155                 160 


Val His Met Asn Asn Val Thr Val Thr Leu His Asp Ala Thr Ile Gln 
                165                 170                 175     


Ala Tyr Leu Ser Asn Ser Ser Phe Ser Arg Gly Glu Thr Arg Cys Glu 
            180                 185                 190         


Gln Asp Arg Pro Ser Pro Thr Thr Ala Pro Pro Ala Pro Pro Ser Pro 
        195                 200                 205             


Ser Pro Ser Pro Val Pro Lys Ser Pro Ser Val Asp Lys Tyr Asn Val 
    210                 215                 220                 


Ser Gly Thr Asn Gly Thr Cys Leu Leu Ala Ser Met Gly Leu Gln Leu 
225                 230                 235                 240 


Asn Leu Thr Tyr Glu Arg Lys Asp Asn Thr Thr Val Thr Arg Leu Leu 
                245                 250                 255     


Asn Ile Asn Pro Asn Lys Thr Ser Ala Ser Gly Ser Cys Gly Ala His 
            260                 265                 270         


Leu Val Thr Leu Glu Leu His Ser Glu Gly Thr Thr Val Leu Leu Phe 
        275                 280                 285             


Gln Phe Gly Met Asn Ala Ser Ser Ser Arg Phe Phe Leu Gln Gly Ile 
    290                 295                 300                 


Gln Leu Asn Thr Ile Leu Pro Asp Ala Arg Asp Pro Ala Phe Lys Ala 
305                 310                 315                 320 


Ala Asn Gly Ser Leu Arg Ala Leu Gln Ala Thr Val Gly Asn Ser Tyr 
                325                 330                 335     


Lys Cys Asn Ala Glu Glu His Val Arg Val Thr Lys Ala Phe Ser Val 
            340                 345                 350         


Asn Ile Phe Lys Val Trp Val Gln Ala Phe Lys Val Glu Gly Gly Gln 
        355                 360                 365             


Phe Gly Ser Val Glu Glu Cys Leu Leu Asp Glu Asn Ser Met Leu Ile 
    370                 375                 380                 


Pro Ile Ala Val Gly Gly Ala Leu Ala Gly Leu Val Leu Ile Val Leu 
385                 390                 395                 400 


Ile Ala Tyr Leu Val Gly Arg Lys Arg Ser His Ala Gly Tyr Gln Thr 
                405                 410                 415     


Ile 
    


<210>  264
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  264

Met Thr Pro Gly Arg Cys Cys Leu Ala Ala Asp Ile Gln Val Glu Thr 
1               5                   10                  15      


Phe Ile Phe Thr Asp Gly Glu Asp Glu Ala Leu Ala Arg His Thr Gly 
            20                  25                  30          


Asn Val Val Ile Thr Asn Cys Ser Ala Ala His Ser Arg Gln Ala Leu 
        35                  40                  45              


Ser Cys Lys Met Ala Val Glu Tyr Asp Arg Phe Ile Glu Ser Gly Arg 
    50                  55                  60                  


Lys Trp Phe Cys His Val Asp Asp Asp Asn Tyr Val Asn Leu Arg Ala 
65                  70                  75                  80  


Leu Leu Arg Leu Leu Ala Ser Tyr Pro His Thr Arg Asp Val Tyr Val 
                85                  90                  95      


Gly Lys Pro Ser Leu Asp Arg Pro Ile Gln Ala Met Glu Arg Val Ser 
            100                 105                 110         


Glu Asn Lys Val Arg Pro Val His Phe Trp Phe Ala Thr Gly Gly Ala 
        115                 120                 125             


Gly Phe Cys Ile Ser Arg Gly Leu Ala Leu Lys Met Ser Pro Trp Ala 
    130                 135                 140                 


Ser Gly Gly His Phe Met Asn Thr Ala Glu Arg Ile Arg Leu Pro Asp 
145                 150                 155                 160 


Asp Cys Thr Ile Gly Tyr Ile Val Glu Ala Leu Leu Gly Val Pro Leu 
                165                 170                 175     


Ile Arg Ser Gly Leu Phe His Ser His Leu Glu Asn Leu Gln Gln Val 
            180                 185                 190         


Pro Thr Ser Glu Leu His Glu Gln Val Thr Leu Ser Tyr Gly Met Phe 
        195                 200                 205             


Glu Asn Lys Arg Asn Ala Val His Val Lys Gly Pro Phe Ser Val Glu 
    210                 215                 220                 


Ala Asp Pro Ser Arg Phe Arg Ser Ile His Cys His Leu Tyr Pro Asp 
225                 230                 235                 240 


Thr Pro Trp Cys Pro Arg Thr Ala Ile Phe 
                245                 250 


<210>  265
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Cys His Val Ile Val Thr Cys Arg Ser Met Leu Trp Thr Leu Leu 
1               5                   10                  15      


Ser Ile Val Val Ala Phe Ala Glu Leu Ile Ala Phe Met Ser Ala Asp 
            20                  25                  30          


Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly Gly Val Glu Pro Ala Gly 
        35                  40                  45              


Pro Gly Gly Gly Ser Pro Glu Pro Tyr His Pro Thr Leu Gly Ile Tyr 
    50                  55                  60                  


Ala Arg Cys Ile Arg Asn Pro Gly Val Gln His Phe Gln Arg Asp Thr 
65                  70                  75                  80  


Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly Glu Ile Ala Ser Gly Phe 
                85                  90                  95      


Trp Gln Ala Thr Ala Ile Phe Leu Ala Val Gly Ile Phe Ile Leu Cys 
            100                 105                 110         


Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val Gln Ser Ile Met 
        115                 120                 125             


Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly 
    130                 135                 140                 


Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys 
145                 150                 155                 160 


Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro 
                165                 170                 175     


Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr 
            180                 185                 190         


Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala 
        195                 200                 205             


Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu 
    210                 215                 220                 


Ile Cys Leu Leu 
225             


<210>  266
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  266

Met Thr Pro Ala Leu Thr Ala Leu Leu Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr Arg Val Gln Ala Gly Pro Phe Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Ser Trp Gly Ser Pro Val Thr Ile Trp 
        35                  40                  45              


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Gln Leu Asp Lys Glu Gly 
    50                  55                  60                  


Ser Pro Glu Pro Leu Asp Arg Asn Asn Pro Leu Glu Pro Lys Asn Lys 
65                  70                  75                  80  


Ala Arg Phe Ser Ile Pro Ser Met Thr Gln His His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys His Tyr Tyr Ser Ser Ala Gly Trp Ser Glu Pro Ser Asp Pro 
            100                 105                 110         


Leu Glu Leu Val Met Thr Gly Phe Tyr Asn Lys Pro Thr Leu Ser Ala 
        115                 120                 125             


Leu Pro Ser Pro Val Val Ala Ser Gly Gly Asn Met Thr Leu Arg Cys 
    130                 135                 140                 


Gly Ser Gln Lys Gly Tyr His His Phe Val Leu Met Lys Glu Gly Glu 
145                 150                 155                 160 


His Gln Leu Pro Arg Thr Leu Asp Ser Gln Gln Leu His Ser Gly Gly 
                165                 170                 175     


Phe Gln Ala Leu Phe Pro Val Gly Pro Val Thr Pro Ser His Arg Trp 
            180                 185                 190         


Arg Phe Thr Cys Tyr Tyr Tyr Tyr Thr Asn Thr Pro Arg Val Trp Ser 
        195                 200                 205             


His Pro Ser Asp Pro Leu Glu Ile Leu Pro Ser Gly Val Ser Arg Lys 
    210                 215                 220                 


Pro Ser Leu Leu Thr Leu Gln Gly Pro Val Leu Ala Pro Gly Gln Ser 
225                 230                 235                 240 


Leu Thr Leu Gln Cys Gly Ser Asp Val Gly Tyr Asp Arg Phe Val Leu 
                245                 250                 255     


Tyr Lys Glu Gly Glu Arg Asp Phe Leu Gln Arg Pro Gly Gln Gln Pro 
            260                 265                 270         


Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser Pro 
        275                 280                 285             


Ser His Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser Ser 
    290                 295                 300                 


Glu Trp Ser Ala Pro Ser Asp Pro Leu Asn Ile Leu Met Ala Gly Gln 
305                 310                 315                 320 


Ile Tyr Asp Thr Val Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Ala 
                325                 330                 335     


Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Arg Gly Tyr Phe Asp 
            340                 345                 350         


Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala His Pro Pro Leu Arg Leu 
        355                 360                 365             


Arg Ser Met Tyr Gly Ala His Lys Tyr Gln Ala Glu Phe Pro Met Ser 
    370                 375                 380                 


Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser Tyr 
385                 390                 395                 400 


Ser Ser Asn Pro His Leu Leu Ser Phe Pro Ser Glu Pro Leu Glu Leu 
                405                 410                 415     


Met Val Ser Gly His Ser Gly Gly Ser Ser Leu Pro Pro Thr Gly Pro 
            420                 425                 430         


Pro Ser Thr Pro Gly Leu Gly Arg Tyr Leu Glu Val Leu Ile Gly Val 
        435                 440                 445             


Ser Val Ala Phe Val Leu Leu Leu Phe Leu Leu Leu Phe Leu Leu Leu 
    450                 455                 460                 


Arg Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
465                 470                 475                 480 


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
                485                 490                 495     


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
            500                 505                 510         


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
        515                 520                 525             


Asp Ser Gln Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
    530                 535                 540                 


Ala Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro 
545                 550                 555                 560 


Ser Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu 
                565                 570                 575     


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln 
            580                 585                 590         


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala 
        595                 600                 605             


Thr Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser 
    610                 615                 620                 


Ile Tyr Ala Thr Leu Ala Ile His 
625                 630         


<210>  267
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Pro Glu Ile Val Asp Thr Cys Ser Leu Ala Ser Pro Ala Ser Val 
1               5                   10                  15      


Cys Arg Thr Lys His Leu His Leu Arg Cys Ser Val Asp Phe Thr Arg 
            20                  25                  30          


Arg Thr Leu Thr Gly Thr Ala Ala Leu Thr Val Gln Ser Gln Glu Asp 
        35                  40                  45              


Asn Leu Arg Ser Leu Val Leu Asp Thr Lys Asp Leu Thr Ile Glu Lys 
    50                  55                  60                  


Val Val Ile Asn Gly Gln Glu Val Lys Tyr Ala Leu Gly Glu Arg Gln 
65                  70                  75                  80  


Ser Tyr Lys Gly Ser Pro Met Glu Ile Ser Leu Pro Ile Ala Leu Ser 
                85                  90                  95      


Lys Asn Gln Glu Ile Val Ile Glu Ile Ser Phe Glu Thr Ser Pro Lys 
            100                 105                 110         


Ser Ser Ala Leu Gln Trp Leu Thr Pro Glu Gln Thr Ser Gly Lys Glu 
        115                 120                 125             


His Pro Tyr Leu Phe Ser Gln Cys Gln Ala Ile His Cys Arg Ala Ile 
    130                 135                 140                 


Leu Pro Cys Gln Asp Thr Pro Ser Val Lys Leu Thr Tyr Thr Ala Glu 
145                 150                 155                 160 


Val Ser Val Pro Lys Glu Leu Val Ala Leu Met Ser Ala Ile Arg Asp 
                165                 170                 175     


Gly Glu Thr Pro Asp Pro Glu Asp Pro Ser Arg Lys Ile Tyr Lys Phe 
            180                 185                 190         


Ile Gln Lys Val Pro Ile Pro Cys Tyr Leu Ile Ala Leu Val Val Gly 
        195                 200                 205             


Ala Leu Glu Ser Arg Gln Ile Gly Pro Arg Thr Leu Val Trp Ser Glu 
    210                 215                 220                 


Lys Glu Gln Val Glu Lys Ser Ala Tyr Glu Phe Ser Glu Thr Glu Ser 
225                 230                 235                 240 


Met Leu Lys Ile Ala Glu Asp Leu Gly Gly Pro Tyr Val Trp Gly Gln 
                245                 250                 255     


Tyr Asp Leu Leu Val Leu Pro Pro Ser Phe Pro Tyr Gly Gly Met Glu 
            260                 265                 270         


Asn Pro Cys Leu Thr Phe Val Thr Pro Thr Leu Leu Ala Gly Asp Lys 
        275                 280                 285             


Ser Leu Ser Asn Val Ile Ala His Glu Ile Ser His Ser Trp Thr Gly 
    290                 295                 300                 


Asn Leu Val Thr Asn Lys Thr Trp Asp His Phe Trp Leu Asn Glu Gly 
305                 310                 315                 320 


His Thr Val Tyr Leu Glu Arg His Ile Cys Gly Arg Leu Phe Gly Glu 
                325                 330                 335     


Lys Phe Arg His Phe Asn Ala Leu Gly Gly Trp Gly Glu Leu Gln Asn 
            340                 345                 350         


Ser Val Lys Thr Phe Gly Glu Thr His Pro Phe Thr Lys Leu Val Val 
        355                 360                 365             


Asp Leu Thr Asp Ile Asp Pro Asp Val Ala Tyr Ser Ser Val Pro Tyr 
    370                 375                 380                 


Glu Lys Gly Phe Ala Leu Leu Phe Tyr Leu Glu Gln Leu Leu Gly Gly 
385                 390                 395                 400 


Pro Glu Ile Phe Leu Gly Phe Leu Lys Ala Tyr Val Glu Lys Phe Ser 
                405                 410                 415     


Tyr Lys Ser Ile Thr Thr Asp Asp Trp Lys Asp Phe Leu Tyr Ser Tyr 
            420                 425                 430         


Phe Lys Asp Lys Val Asp Val Leu Asn Gln Val Asp Trp Asn Ala Trp 
        435                 440                 445             


Leu Tyr Ser Pro Gly Leu Pro Pro Ile Lys Pro Asn Tyr Asp Met Thr 
    450                 455                 460                 


Leu Thr Asn Ala Cys Ile Ala Leu Ser Gln Arg Trp Ile Thr Ala Lys 
465                 470                 475                 480 


Glu Asp Asp Leu Asn Ser Phe Asn Ala Thr Asp Leu Lys Asp Leu Ser 
                485                 490                 495     


Ser His Gln Leu Asn Glu Phe Leu Ala Gln Thr Leu Gln Arg Ala Pro 
            500                 505                 510         


Leu Pro Leu Gly His Ile Lys Arg Met Gln Glu Val Tyr Asn Phe Asn 
        515                 520                 525             


Ala Ile Asn Asn Ser Glu Ile Arg Phe Arg Trp Leu Arg Leu Cys Ile 
    530                 535                 540                 


Gln Ser Lys Trp Glu Asp Ala Ile Pro Leu Ala Leu Lys Met Ala Thr 
545                 550                 555                 560 


Glu Gln Gly Arg Met Lys Phe Thr Arg Pro Leu Phe Lys Asp Leu Ala 
                565                 570                 575     


Ala Phe Asp Lys Ser His Asp Gln Ala Val Arg Thr Tyr Gln Glu His 
            580                 585                 590         


Lys Ala Ser Met His Pro Val Thr Ala Met Leu Val Gly Lys Asp Leu 
        595                 600                 605             


Lys Val Asp 
    610     


<210>  268
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  268

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  269
<211>  820
<212>  PRT
<213>  Homo sapiens

<400>  269

Met Ala Leu Leu Arg Asp Val Ser Leu Gln Asp Pro Arg Asp Arg Phe 
1               5                   10                  15      


Glu Leu Leu Gln Arg Val Gly Ala Gly Thr Tyr Gly Asp Val Tyr Lys 
            20                  25                  30          


Ala Arg Asp Thr Val Thr Ser Glu Leu Ala Ala Val Lys Ile Val Lys 
        35                  40                  45              


Leu Asp Pro Gly Asp Asp Ile Ser Ser Leu Gln Gln Glu Ile Thr Ile 
    50                  55                  60                  


Leu Arg Glu Cys Arg His Pro Asn Val Val Ala Tyr Ile Gly Ser Tyr 
65                  70                  75                  80  


Leu Arg Asn Asp Arg Leu Trp Ile Cys Met Glu Phe Cys Gly Gly Gly 
                85                  90                  95      


Ser Leu Gln Glu Ile Tyr His Ala Thr Gly Pro Leu Glu Glu Arg Gln 
            100                 105                 110         


Ile Ala Tyr Val Cys Arg Glu Ala Leu Lys Gly Leu His His Leu His 
        115                 120                 125             


Ser Gln Gly Lys Ile His Arg Asp Ile Lys Gly Ala Asn Leu Leu Leu 
    130                 135                 140                 


Thr Leu Gln Gly Asp Val Lys Leu Ala Asp Phe Gly Val Ser Gly Glu 
145                 150                 155                 160 


Leu Thr Ala Ser Val Ala Lys Arg Arg Ser Phe Ile Gly Thr Pro Tyr 
                165                 170                 175     


Trp Met Ala Pro Glu Val Ala Ala Val Glu Arg Lys Gly Gly Tyr Asn 
            180                 185                 190         


Glu Leu Cys Asp Val Trp Ala Leu Gly Ile Thr Ala Ile Glu Leu Gly 
        195                 200                 205             


Glu Leu Gln Pro Pro Leu Phe His Leu His Pro Met Arg Ala Leu Met 
    210                 215                 220                 


Leu Met Ser Lys Ser Ser Phe Gln Pro Pro Lys Leu Arg Asp Lys Thr 
225                 230                 235                 240 


Arg Trp Thr Gln Asn Phe His His Phe Leu Lys Leu Ala Leu Thr Lys 
                245                 250                 255     


Asn Pro Lys Lys Arg Pro Thr Ala Glu Lys Leu Leu Gln His Pro Phe 
            260                 265                 270         


Thr Thr Gln Gln Leu Pro Arg Ala Leu Leu Thr Gln Leu Leu Asp Lys 
        275                 280                 285             


Ala Ser Asp Pro His Leu Gly Thr Pro Ser Pro Glu Asp Cys Glu Leu 
    290                 295                 300                 


Glu Thr Tyr Asp Met Phe Pro Asp Thr Ile His Ser Arg Gly Gln His 
305                 310                 315                 320 


Gly Pro Ala Glu Arg Thr Pro Ser Glu Ile Gln Phe His Gln Val Lys 
                325                 330                 335     


Phe Gly Ala Pro Arg Arg Lys Glu Thr Asp Pro Leu Asn Glu Pro Trp 
            340                 345                 350         


Glu Glu Glu Trp Thr Leu Leu Gly Lys Glu Glu Leu Ser Gly Ser Leu 
        355                 360                 365             


Leu Gln Ser Val Gln Glu Ala Leu Glu Glu Arg Ser Leu Thr Ile Arg 
    370                 375                 380                 


Ser Ala Ser Glu Phe Gln Glu Leu Asp Ser Pro Asp Asp Thr Met Gly 
385                 390                 395                 400 


Thr Ile Lys Arg Ala Pro Phe Leu Gly Pro Leu Pro Thr Asp Pro Pro 
                405                 410                 415     


Ala Glu Glu Pro Leu Ser Ser Pro Pro Gly Thr Leu Pro Pro Pro Pro 
            420                 425                 430         


Ser Gly Pro Asn Ser Ser Pro Leu Leu Pro Thr Ala Trp Ala Thr Met 
        435                 440                 445             


Lys Gln Arg Glu Asp Pro Glu Arg Ser Ser Cys His Gly Leu Pro Pro 
    450                 455                 460                 


Thr Pro Lys Val His Met Gly Ala Cys Phe Ser Lys Val Phe Asn Gly 
465                 470                 475                 480 


Cys Pro Leu Arg Ile His Ala Ala Val Thr Trp Ile His Pro Val Thr 
                485                 490                 495     


Arg Asp Gln Phe Leu Val Val Gly Ala Glu Glu Gly Ile Tyr Thr Leu 
            500                 505                 510         


Asn Leu His Glu Leu His Glu Asp Thr Leu Glu Lys Leu Ile Ser His 
        515                 520                 525             


Arg Cys Ser Trp Leu Tyr Cys Val Asn Asn Val Leu Leu Ser Leu Ser 
    530                 535                 540                 


Gly Lys Ser Thr His Ile Trp Ala His Asp Leu Pro Gly Leu Phe Glu 
545                 550                 555                 560 


Gln Arg Arg Leu Gln Gln Gln Val Pro Leu Ser Ile Pro Thr Asn Arg 
                565                 570                 575     


Leu Thr Gln Arg Ile Ile Pro Arg Arg Phe Ala Leu Ser Thr Lys Ile 
            580                 585                 590         


Pro Asp Thr Lys Gly Cys Leu Gln Cys Arg Val Val Arg Asn Pro Tyr 
        595                 600                 605             


Thr Gly Ala Thr Phe Leu Leu Ala Ala Leu Pro Thr Ser Leu Leu Leu 
    610                 615                 620                 


Leu Gln Trp Tyr Glu Pro Leu Gln Lys Phe Leu Leu Leu Lys Asn Phe 
625                 630                 635                 640 


Ser Ser Pro Leu Pro Ser Pro Ala Gly Met Leu Glu Pro Leu Val Leu 
                645                 650                 655     


Asp Gly Lys Glu Leu Pro Gln Val Cys Val Gly Ala Glu Gly Pro Glu 
            660                 665                 670         


Gly Pro Gly Cys Arg Val Leu Phe His Val Leu Pro Leu Glu Ala Gly 
        675                 680                 685             


Leu Thr Pro Asp Ile Leu Ile Pro Pro Glu Gly Ile Pro Gly Ser Ala 
    690                 695                 700                 


Gln Gln Val Ile Gln Val Asp Arg Asp Thr Ile Leu Val Ser Phe Glu 
705                 710                 715                 720 


Arg Cys Val Arg Ile Val Asn Met Gln Gly Glu Pro Thr Ala Thr Leu 
                725                 730                 735     


Ala Pro Glu Leu Thr Phe Asp Phe Pro Ile Glu Thr Val Val Cys Leu 
            740                 745                 750         


Gln Asp Ser Val Leu Ala Phe Trp Ser His Gly Met Gln Gly Arg Ser 
        755                 760                 765             


Leu Asp Thr Asn Glu Val Thr Gln Glu Ile Thr Asp Glu Thr Arg Ile 
    770                 775                 780                 


Phe Arg Val Leu Gly Ala His Arg Asp Ile Ile Leu Glu Ser Ile Pro 
785                 790                 795                 800 


Thr Asp Asn Pro Glu Ala His Ser Asn Leu Tyr Ile Leu Thr Gly His 
                805                 810                 815     


Gln Ser Thr Tyr 
            820 


<210>  270
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  270

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asn Gln Leu Gln Gln Ile Met Arg Leu Thr Gly 
225                 230                 235                 240 


Thr Pro Pro Ala Tyr Leu Ile Asn Arg Met Pro Ser His Glu Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  271
<211>  1336
<212>  PRT
<213>  Homo sapiens

<400>  271

Met Met Glu Ile Gln Met Asp Glu Gly Gly Gly Val Val Val Tyr Gln 
1               5                   10                  15      


Asp Asp Tyr Cys Ser Gly Ser Val Met Ser Glu Arg Val Ser Gly Leu 
            20                  25                  30          


Ala Gly Ser Ile Tyr Arg Glu Phe Glu Arg Leu Ile His Cys Tyr Asp 
        35                  40                  45              


Glu Glu Val Val Lys Glu Leu Met Pro Leu Val Val Asn Val Leu Glu 
    50                  55                  60                  


Asn Leu Asp Ser Val Leu Ser Glu Asn Gln Glu His Glu Val Glu Leu 
65                  70                  75                  80  


Glu Leu Leu Arg Glu Asp Asn Glu Gln Leu Leu Thr Gln Tyr Glu Arg 
                85                  90                  95      


Glu Lys Ala Leu Arg Arg Gln Ala Glu Glu Lys Phe Ile Glu Phe Glu 
            100                 105                 110         


Asp Ala Leu Glu Gln Glu Lys Lys Glu Leu Gln Ile Gln Val Glu His 
        115                 120                 125             


Tyr Glu Phe Gln Thr Arg Gln Leu Glu Leu Lys Ala Lys Asn Tyr Ala 
    130                 135                 140                 


Asp Gln Ile Ser Arg Leu Glu Glu Arg Glu Ser Glu Met Lys Lys Glu 
145                 150                 155                 160 


Tyr Asn Ala Leu His Gln Arg His Thr Glu Met Ile Gln Thr Tyr Val 
                165                 170                 175     


Glu His Ile Glu Arg Ser Lys Met Gln Gln Val Gly Gly Asn Ser Gln 
            180                 185                 190         


Thr Glu Ser Ser Leu Pro Gly Arg Arg Lys Glu Arg Pro Thr Ser Leu 
        195                 200                 205             


Asn Val Phe Pro Leu Ala Asp Gly Thr Val Arg Ala Gln Ile Gly Gly 
    210                 215                 220                 


Lys Leu Val Pro Ala Gly Asp His Trp His Leu Ser Asp Leu Gly Gln 
225                 230                 235                 240 


Leu Gln Ser Ser Ser Ser Tyr Gln Cys Pro Gln Asp Glu Met Ser Glu 
                245                 250                 255     


Ser Gly Gln Ser Ser Ala Ala Ala Thr Pro Ser Thr Thr Gly Thr Lys 
            260                 265                 270         


Ser Asn Thr Pro Thr Ser Ser Val Pro Ser Ala Ala Val Thr Pro Leu 
        275                 280                 285             


Asn Glu Ser Leu Gln Pro Leu Gly Asp Tyr Gly Val Gly Ser Lys Asn 
    290                 295                 300                 


Ser Lys Arg Ala Arg Glu Lys Arg Asp Ser Arg Asn Met Glu Val Gln 
305                 310                 315                 320 


Val Thr Gln Glu Met Arg Asn Val Ser Ile Gly Met Gly Ser Ser Asp 
                325                 330                 335     


Glu Trp Ser Asp Val Gln Asp Ile Ile Asp Ser Thr Pro Glu Leu Asp 
            340                 345                 350         


Met Cys Pro Glu Thr Arg Leu Asp Arg Thr Gly Ser Ser Pro Thr Gln 
        355                 360                 365             


Gly Ile Val Asn Lys Ala Phe Gly Ile Asn Thr Asp Ser Leu Tyr His 
    370                 375                 380                 


Glu Leu Ser Thr Ala Gly Ser Glu Val Ile Gly Asp Val Asp Glu Gly 
385                 390                 395                 400 


Ala Asp Leu Leu Gly Glu Phe Ser Val Arg Asp Asp Phe Phe Gly Met 
                405                 410                 415     


Gly Lys Glu Val Gly Asn Leu Leu Leu Glu Asn Ser Gln Leu Leu Glu 
            420                 425                 430         


Thr Lys Asn Ala Leu Asn Val Val Lys Asn Asp Leu Ile Ala Lys Val 
        435                 440                 445             


Asp Gln Leu Ser Gly Glu Gln Glu Val Leu Arg Gly Glu Leu Glu Ala 
    450                 455                 460                 


Ala Lys Gln Ala Lys Val Lys Leu Glu Asn Arg Ile Lys Glu Leu Glu 
465                 470                 475                 480 


Glu Glu Leu Lys Arg Val Lys Ser Glu Ala Ile Ile Ala Arg Arg Glu 
                485                 490                 495     


Pro Lys Glu Glu Ala Glu Asp Val Ser Ser Tyr Leu Cys Thr Glu Ser 
            500                 505                 510         


Asp Lys Ile Pro Met Ala Gln Arg Arg Arg Phe Thr Arg Val Glu Met 
        515                 520                 525             


Ala Arg Val Leu Met Glu Arg Asn Gln Tyr Lys Glu Arg Leu Met Glu 
    530                 535                 540                 


Leu Gln Glu Ala Val Arg Trp Thr Glu Met Ile Arg Ala Ser Arg Glu 
545                 550                 555                 560 


His Pro Ser Val Gln Glu Lys Lys Lys Ser Thr Ile Trp Gln Phe Phe 
                565                 570                 575     


Ser Arg Leu Phe Ser Ser Ser Ser Ser Pro Pro Pro Ala Lys Arg Pro 
            580                 585                 590         


Tyr Pro Ser Val Asn Ile His Tyr Lys Ser Pro Thr Thr Ala Gly Phe 
        595                 600                 605             


Ser Gln Arg Arg Asn His Ala Met Cys Pro Ile Ser Ala Gly Ser Arg 
    610                 615                 620                 


Pro Leu Glu Phe Phe Pro Asp Asp Asp Cys Thr Ser Ser Ala Arg Arg 
625                 630                 635                 640 


Glu Gln Lys Arg Glu Gln Tyr Arg Gln Val Arg Glu His Val Arg Asn 
                645                 650                 655     


Asp Asp Gly Arg Leu Gln Ala Cys Gly Trp Ser Leu Pro Ala Lys Tyr 
            660                 665                 670         


Lys Gln Leu Ser Pro Asn Gly Gly Gln Glu Asp Thr Arg Met Lys Asn 
        675                 680                 685             


Val Pro Val Pro Val Tyr Cys Arg Pro Leu Val Glu Lys Asp Pro Thr 
    690                 695                 700                 


Met Lys Leu Trp Cys Ala Ala Gly Val Asn Leu Ser Gly Trp Arg Pro 
705                 710                 715                 720 


Asn Glu Asp Asp Ala Gly Asn Gly Val Lys Pro Ala Pro Gly Arg Asp 
                725                 730                 735     


Pro Leu Thr Cys Asp Arg Glu Gly Asp Gly Glu Pro Lys Ser Ala His 
            740                 745                 750         


Thr Ser Pro Glu Lys Lys Lys Ala Lys Glu Leu Pro Glu Met Asp Ala 
        755                 760                 765             


Thr Ser Ser Arg Val Trp Ile Leu Thr Ser Thr Leu Thr Thr Ser Lys 
    770                 775                 780                 


Val Val Ile Ile Asp Ala Asn Gln Pro Gly Thr Val Val Asp Gln Phe 
785                 790                 795                 800 


Thr Val Cys Asn Ala His Val Leu Cys Ile Ser Ser Ile Pro Ala Ala 
                805                 810                 815     


Ser Asp Ser Asp Tyr Pro Pro Gly Glu Met Phe Leu Asp Ser Asp Val 
            820                 825                 830         


Asn Pro Glu Asp Pro Gly Ala Asp Gly Val Leu Ala Gly Ile Thr Leu 
        835                 840                 845             


Val Gly Cys Ala Thr Arg Cys Asn Val Pro Arg Ser Asn Cys Ser Ser 
    850                 855                 860                 


Arg Gly Asp Thr Pro Val Leu Asp Lys Gly Gln Gly Glu Val Ala Thr 
865                 870                 875                 880 


Ile Ala Asn Gly Lys Val Asn Pro Ser Gln Ser Thr Glu Glu Ala Thr 
                885                 890                 895     


Glu Ala Thr Glu Val Pro Asp Pro Gly Pro Ser Glu Pro Glu Thr Ala 
            900                 905                 910         


Thr Leu Arg Pro Gly Pro Leu Thr Glu His Val Phe Thr Asp Pro Ala 
        915                 920                 925             


Pro Thr Pro Ser Ser Gly Pro Gln Pro Gly Ser Glu Asn Gly Pro Glu 
    930                 935                 940                 


Pro Asp Ser Ser Ser Thr Arg Pro Glu Pro Glu Pro Ser Gly Asp Pro 
945                 950                 955                 960 


Thr Gly Ala Gly Ser Ser Ala Ala Pro Thr Met Trp Leu Gly Ala Gln 
                965                 970                 975     


Asn Gly Trp Leu Tyr Val His Ser Ala Val Ala Asn Trp Lys Lys Cys 
            980                 985                 990         


Leu His Ser Ile Lys Leu Lys Asp  Ser Val Leu Ser Leu  Val His Val 
        995                 1000                 1005             


Lys Gly  Arg Val Leu Val Ala  Leu Ala Asp Gly Thr  Leu Ala Ile 
    1010                 1015                 1020             


Phe His  Arg Gly Glu Asp Gly  Gln Trp Asp Leu Ser  Asn Tyr His 
    1025                 1030                 1035             


Leu Met  Asp Leu Gly His Pro  His His Ser Ile Arg  Cys Met Ala 
    1040                 1045                 1050             


Val Val  Tyr Asp Arg Val Trp  Cys Gly Tyr Lys Asn  Lys Val His 
    1055                 1060                 1065             


Val Ile  Gln Pro Lys Thr Met  Gln Ile Glu Lys Ser  Phe Asp Ala 
    1070                 1075                 1080             


His Pro  Arg Arg Glu Ser Gln  Val Arg Gln Leu Ala  Trp Ile Gly 
    1085                 1090                 1095             


Asp Gly  Val Trp Val Ser Ile  Arg Leu Asp Ser Thr  Leu Arg Leu 
    1100                 1105                 1110             


Tyr His  Ala His Thr His Gln  His Leu Gln Asp Val  Asp Ile Glu 
    1115                 1120                 1125             


Pro Tyr  Val Ser Lys Met Leu  Gly Thr Gly Lys Leu  Gly Phe Ser 
    1130                 1135                 1140             


Phe Val  Arg Ile Thr Ala Leu  Leu Val Ala Gly Ser  Arg Leu Trp 
    1145                 1150                 1155             


Val Gly  Thr Gly Asn Gly Val  Val Ile Ser Ile Pro  Leu Thr Glu 
    1160                 1165                 1170             


Thr Val  Val Leu His Arg Gly  Gln Leu Leu Gly Leu  Arg Ala Asn 
    1175                 1180                 1185             


Lys Thr  Ser Pro Thr Ser Gly  Glu Gly Ala Arg Pro  Gly Gly Ile 
    1190                 1195                 1200             


Ile His  Val Tyr Gly Asp Asp  Ser Ser Asp Arg Ala  Ala Ser Ser 
    1205                 1210                 1215             


Phe Ile  Pro Tyr Cys Ser Met  Ala Gln Ala Gln Leu  Cys Phe His 
    1220                 1225                 1230             


Gly His  Arg Asp Ala Val Lys  Phe Phe Val Ser Val  Pro Gly Asn 
    1235                 1240                 1245             


Val Leu  Ala Thr Leu Asn Gly  Ser Val Leu Asp Ser  Pro Ala Glu 
    1250                 1255                 1260             


Gly Pro  Gly Pro Ala Ala Pro  Ala Ser Glu Val Glu  Gly Gln Lys 
    1265                 1270                 1275             


Leu Arg  Asn Val Leu Val Leu  Ser Gly Gly Glu Gly  Tyr Ile Asp 
    1280                 1285                 1290             


Phe Arg  Ile Gly Asp Gly Glu  Asp Asp Glu Thr Glu  Glu Gly Ala 
    1295                 1300                 1305             


Gly Asp  Met Ser Gln Val Lys  Pro Val Leu Ser Lys  Ala Glu Arg 
    1310                 1315                 1320             


Ser His  Ile Ile Val Trp Gln  Val Ser Tyr Thr Pro  Glu 
    1325                 1330                 1335     


<210>  272
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Glu Pro Arg Ala Ala Ala Ala Gly Glu Pro Glu Pro Pro Ala Ala 
1               5                   10                  15      


Ser Ser Ser Phe Gln Ala Arg Leu Trp Lys Asn Leu Gln Leu Gly Val 
            20                  25                  30          


Gly Arg Ser Lys Gly Gly Gly Gly Gly Arg Ala Gly Gly Pro Glu Arg 
        35                  40                  45              


Arg Thr Ala Asp Thr Pro Ser Pro Ser Pro Pro Pro Pro Val Gly Thr 
    50                  55                  60                  


Gly Asn Ala Pro Ala Arg Gly Ser Gly Ala Gly Ser Arg Trp Ser Gly 
65                  70                  75                  80  


Phe Lys Lys Arg Lys Gln Val Leu Asp Arg Val Phe Ser Ser Ser Gln 
                85                  90                  95      


Pro Asn Leu Cys Cys Ser Ser Pro Glu Pro Leu Glu Pro Gly Gly Ala 
            100                 105                 110         


Gly Arg Ala Glu Gln Gly Ser Thr Leu Arg Arg Arg Ile Arg Glu His 
        115                 120                 125             


Leu Leu Pro Ala Val Lys Gly Pro Ala Ala Ala Ser Gly Ala Ala Gly 
    130                 135                 140                 


Gly Thr Pro Pro Gly Gly Arg Ser Pro Asp Ser Ala Pro Ser Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Leu Ser Ser Ser Pro Gln Pro Pro Pro Arg Gly 
                165                 170                 175     


Asp Arg Ala Arg Asp Glu Gly Ala Arg Arg Gln Gly Pro Gly Ala His 
            180                 185                 190         


Leu Cys His Gln Lys Ser Ser Ser Leu Pro Gly Thr Ala Cys Leu Glu 
        195                 200                 205             


Gln Leu Leu Glu Pro Pro Pro Pro Pro Ala Glu Pro Ala Arg Ser Pro 
    210                 215                 220                 


Ala Glu Ser Arg Ala Pro Glu Thr Gly Glu Glu His Gly Ser Ser Gln 
225                 230                 235                 240 


Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val Pro Leu Ala 
                245                 250                 255     


Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg Gly Gln Ser 
            260                 265                 270         


Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr Val Lys Phe 
        275                 280                 285             


Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile His Lys Asn 
    290                 295                 300                 


Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val Asp His Leu 
305                 310                 315                 320 


Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe Gly Leu Gln 
                325                 330                 335     


Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln Leu Glu Leu 
            340                 345                 350         


Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro His Tyr Pro 
        355                 360                 365             


Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu Thr Pro Lys 
    370                 375                 380                 


Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys Ser Trp Lys 
385                 390                 395                 400 


Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly Ser Tyr Phe 
                405                 410                 415     


Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro Ala Leu Pro 
            420                 425                 430         


Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr Cys Lys Asn 
        435                 440                 445             


Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu His Arg Lys 
    450                 455                 460                 


Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile Glu Gly Arg 
465                 470                 475                 480 


Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro Tyr Val Lys 
                485                 490                 495     


Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met Pro Lys Thr 
            500                 505                 510         


Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu Tyr Glu Glu 
        515                 520                 525             


Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp Ala Gly Lys 
    530                 535                 540                 


Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser Ala Leu Ser 
545                 550                 555                 560 


Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu Gly Glu Gly 
                565                 570                 575     


His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr Val Ser Ile 
            580                 585                 590         


Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu Arg Glu Glu 
        595                 600                 605             


Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn Leu Lys Asp 
    610                 615                 620                 


Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly Leu Met Ala 
625                 630                 635                 640 


Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val Glu Leu Asn 
                645                 650                 655     


Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu 
            660                 665                 670         


Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His Ser Val Leu 
        675                 680                 685             


Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp Phe Leu 
    690                 695                 700                 


Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu Gln Lys 
705                 710                 715                 720 


Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr Lys Gly Val 
                725                 730                 735     


Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys Ala Ser Leu 
            740                 745                 750         


Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu Asn Arg 
        755                 760                 765             


Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met Lys Arg Cys 
    770                 775                 780                 


Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys Phe Asp 
785                 790                 795                 800 


Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu Phe Leu Phe 
                805                 810                 815     


Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val Leu Leu Leu 
            820                 825                 830         


Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys Asp Asn Arg 
        835                 840                 845             


Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu 
    850                 855                 860                 


Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys 
865                 870                 875                 880 


Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp 
                885                 890                 895     


Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr 
            900                 905                 910         


Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr 
        915                 920                 925             


Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly 
    930                 935                 940                 


Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn 
945                 950                 955                 960 


Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val 
                965                 970                 975     


Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys 
            980                 985                 990         


Arg Lys Lys Asn Asn Leu Gly 
        995                 


<210>  273
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Asn Gly Gly Ala Glu Arg Ala Met Arg Ser Leu Pro Ser Leu Gly 
1               5                   10                  15      


Gly Leu Ala Leu Leu Cys Cys Ala Ala Ala Ala Ala Ala Ala Ala Val 
            20                  25                  30          


Ala Ser Ala Ala Ser Ala Gly Asn Val Thr Gly Gly Gly Gly Ala Ala 
        35                  40                  45              


Gly Gln Val Asp Ala Ser Pro Gly Pro Gly Leu Arg Gly Glu Pro Ser 
    50                  55                  60                  


His Pro Phe Pro Arg Ala Thr Ala Pro Thr Ala Gln Ala Pro Arg Thr 
65                  70                  75                  80  


Gly Pro Pro Arg Ala Thr Val His Arg Pro Leu Ala Ala Thr Ser Pro 
                85                  90                  95      


Ala Gln Ser Pro Glu Thr Thr Pro Leu Trp Ala Thr Ala Gly Pro Ser 
            100                 105                 110         


Ser Thr Thr Phe Gln Ala Pro Leu Gly Pro Ser Pro Thr Thr Pro Pro 
        115                 120                 125             


Ala Ala Glu Arg Thr Ser Thr Thr Ser Gln Ala Pro Thr Arg Pro Ala 
    130                 135                 140                 


Pro Thr Thr Leu Ser Thr Thr Thr Gly Pro Ala Pro Thr Thr Pro Val 
145                 150                 155                 160 


Ala Thr Thr Val Pro Ala Pro Thr Thr Pro Arg Thr Pro Thr Pro Asp 
                165                 170                 175     


Leu Pro Ser Ser Ser Asn Ser Ser Val Leu Pro Thr Pro Pro Ala Thr 
            180                 185                 190         


Glu Ala Pro Ser Ser Pro Pro Pro Glu Tyr Val Cys Asn Cys Ser Val 
        195                 200                 205             


Val Gly Ser Leu Asn Val Asn Arg Cys Asn Gln Thr Thr Gly Gln Cys 
    210                 215                 220                 


Glu Cys Arg Pro Gly Tyr Gln Gly Leu His Cys Glu Thr Cys Lys Glu 
225                 230                 235                 240 


Gly Phe Tyr Leu Asn Tyr Thr Ser Gly Leu Cys Gln Pro Cys Asp Cys 
                245                 250                 255     


Ser Pro His Gly Ala Leu Ser Ile Pro Cys Asn Ser Ser Gly Lys Cys 
            260                 265                 270         


Gln Cys Lys Val Gly Val Ile Gly Ser Ile Cys Asp Arg Cys Gln Asp 
        275                 280                 285             


Gly Tyr Tyr Gly Phe Ser Lys Asn Gly Cys Leu Pro Cys Gln Cys Asn 
    290                 295                 300                 


Asn Arg Ser Ala Ser Cys Asp Ala Leu Thr Gly Ala Cys Leu Asn Cys 
305                 310                 315                 320 


Gln Glu Asn Ser Lys Gly Asn His Cys Glu Glu Cys Lys Glu Gly Phe 
                325                 330                 335     


Tyr Gln Ser Pro Asp Ala Thr Lys Glu Cys Leu Arg Cys Pro Cys Ser 
            340                 345                 350         


Ala Val Thr Ser Thr Gly Ser Cys Ser Ile Lys Ser Ser Glu Leu Glu 
        355                 360                 365             


Pro Glu Cys Asp Gln Cys Lys Asp Gly Tyr Ile Gly Pro Asn Cys Asn 
    370                 375                 380                 


Lys Cys Glu Asn Gly Tyr Tyr Asn Phe Asp Ser Ile Cys Arg Lys Cys 
385                 390                 395                 400 


Gln Cys His Gly His Val Asp Pro Val Lys Thr Pro Lys Ile Cys Lys 
                405                 410                 415     


Pro Glu Ser Gly Glu Cys Ile Asn Cys Leu His Asn Thr Thr Gly Phe 
            420                 425                 430         


Trp Cys Glu Asn Cys Leu Glu Gly Tyr Val His Asp Leu Glu Gly Asn 
        435                 440                 445             


Cys Ile Lys Lys Glu Val Ile Leu Pro Thr Pro Glu Gly Ser Thr Ile 
    450                 455                 460                 


Leu Val Ser Asn Ala Ser Leu Thr Thr Ser Val Pro Thr Pro Val Ile 
465                 470                 475                 480 


Asn Ser Thr Phe Thr Pro Thr Thr Leu Gln Thr Ile Phe Ser Val Ser 
                485                 490                 495     


Thr Ser Glu Asn Ser Thr Ser Ala Leu Ala Asp Val Ser Trp Thr Gln 
            500                 505                 510         


Phe Asn Ile Ile Ile Leu Thr Val Ile Ile Ile Val Val Val Leu Leu 
        515                 520                 525             


Met Gly Phe Val Gly Ala Val Tyr Met Tyr Arg Glu Tyr Gln Asn Arg 
    530                 535                 540                 


Lys Leu Asn Ala Pro Phe Trp Thr Ile Glu Leu Lys Glu Asp Asn Ile 
545                 550                 555                 560 


Ser Phe Ser Ser Tyr His Asp Ser Ile Pro Asn Ala Asp Val Ser Gly 
                565                 570                 575     


Leu Leu Glu Asp Asp Gly Asn Glu Val Ala Pro Asn Gly Gln Leu Thr 
            580                 585                 590         


Leu Thr Thr Pro Ile His Asn Tyr Lys Ala 
        595                 600         


<210>  274
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  274

Met Arg Leu Leu Ala Gly Trp Leu Cys Leu Ser Leu Ala Ser Val Trp 
1               5                   10                  15      


Leu Ala Arg Arg Met Trp Thr Leu Arg Ser Pro Leu Thr Arg Ser Leu 
            20                  25                  30          


Tyr Val Asn Met Thr Ser Gly Pro Gly Gly Pro Ala Ala Ala Ala Gly 
        35                  40                  45              


Gly Arg Lys Glu Asn His Gln Trp Tyr Val Cys Asn Arg Glu Lys Leu 
    50                  55                  60                  


Cys Glu Ser Leu Gln Ala Val Phe Val Gln Ser Tyr Leu Asp Gln Gly 
65                  70                  75                  80  


Thr Gln Ile Phe Leu Asn Asn Ser Ile Glu Lys Ser Gly Trp Leu Phe 
                85                  90                  95      


Ile Gln Leu Tyr His Ser Phe Val Ser Ser Val Phe Ser Leu Phe Met 
            100                 105                 110         


Ser Arg Thr Ser Ile Asn Gly Leu Leu Gly Arg Gly Ser Met Phe Val 
        115                 120                 125             


Phe Ser Pro Asp Gln Phe Gln Arg Leu Leu Lys Ile Asn Pro Asp Trp 
    130                 135                 140                 


Lys Thr His Arg Leu Leu Asp Leu Gly Ala Gly Asp Gly Glu Val Thr 
145                 150                 155                 160 


Lys Ile Met Ser Pro His Phe Glu Glu Ile Tyr Ala Thr Glu Leu Ser 
                165                 170                 175     


Glu Thr Met Ile Trp Gln Leu Gln Lys Lys Lys Tyr Arg Val Leu Gly 
            180                 185                 190         


Ile Asn Glu Trp Gln Asn Thr Gly Phe Gln Tyr Asp Val Ile Ser Cys 
        195                 200                 205             


Leu Asn Leu Leu Asp Arg Cys Asp Gln Pro Leu Thr Leu Leu Lys Asp 
    210                 215                 220                 


Ile Arg Ser Val Leu Glu Pro Thr Arg Gly Arg Val Ile Leu Ala Leu 
225                 230                 235                 240 


Val Leu Pro Phe His Pro Tyr Val Glu Asn Val Gly Gly Lys Trp Glu 
                245                 250                 255     


Lys Pro Ser Glu Ile Leu Glu Ile Lys Gly Gln Asn Trp Glu Glu Gln 
            260                 265                 270         


Val Asn Ser Leu Pro Glu Val Phe Arg Lys Ala Gly Phe Val Ile Glu 
        275                 280                 285             


Ala Phe Thr Arg Leu Pro Tyr Leu Cys Glu Gly Asp Met Tyr Asn Asp 
    290                 295                 300                 


Tyr Tyr Val Leu Asp Asp Ala Val Phe Val Leu Lys Pro Val 
305                 310                 315             


<210>  275
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Gly Trp Gly Gly Gly Gly Gly Cys Thr Pro Arg Pro Pro Ile His 
1               5                   10                  15      


Gln Gln Pro Pro Glu Arg Arg Val Val Thr Val Val Phe Leu Gly Leu 
            20                  25                  30          


Leu Leu Asp Leu Leu Ala Phe Thr Leu Leu Leu Pro Leu Leu Pro Gly 
        35                  40                  45              


Leu Leu Glu Ser His Gly Arg Ala His Asp Pro Leu Tyr Gly Ser Trp 
    50                  55                  60                  


Gln Gly Gly Val Asp Trp Phe Ala Thr Ala Ile Gly Met Pro Val Glu 
65                  70                  75                  80  


Lys Arg Tyr Asn Ser Val Leu Phe Gly Gly Leu Ile Gly Ser Ala Phe 
                85                  90                  95      


Ser Val Leu Gln Phe Leu Cys Ala Pro Leu Thr Gly Ala Thr Ser Asp 
            100                 105                 110         


Cys Leu Gly Arg Arg Pro Val Met Leu Leu Cys Leu Met Gly Val Ala 
        115                 120                 125             


Thr Ser Tyr Ala Val Trp Ala Thr Ser Arg Ser Phe Ala Ala Phe Leu 
    130                 135                 140                 


Ala Ser Arg Leu Ile Gly Gly Ile Ser Lys Gly Asn Val Ser Leu Ser 
145                 150                 155                 160 


Thr Ala Ile Val Ala Asp Leu Gly Ser Pro Leu Ala Arg Ser Gln Gly 
                165                 170                 175     


Met Ala Val Ile Gly Val Ala Phe Ser Leu Gly Phe Thr Leu Gly Pro 
            180                 185                 190         


Met Leu Gly Ala Ser Leu Pro Leu Glu Met Ala Pro Trp Phe Ala Leu 
        195                 200                 205             


Leu Phe Ala Ala Ser Asp Leu Leu Phe Ile Phe Cys Phe Leu Pro Glu 
    210                 215                 220                 


Thr Leu Pro Leu Glu Lys Arg Ala Pro Ser Ile Ala Leu Gly Phe Arg 
225                 230                 235                 240 


Asp Ala Ala Asp Leu Leu Ser Pro Leu Ala Leu Leu Arg Phe Ser Ala 
                245                 250                 255     


Val Ala Arg Gly Gln Asp Pro Pro Ser Gly Asp Arg Leu Ser Ser Leu 
            260                 265                 270         


Arg Arg Leu Gly Leu Val Tyr Phe Leu Tyr Leu Phe Leu Phe Ser Gly 
        275                 280                 285             


Leu Glu Tyr Thr Leu Ser Phe Leu Thr His Gln Arg Phe Gln Phe Ser 
    290                 295                 300                 


Ser Leu Gln Gln Gly Lys Met Phe Phe Leu Ile Gly Leu Thr Met Ala 
305                 310                 315                 320 


Thr Ile Gln Gly Ala Tyr Ala Arg Arg Ile His Pro Gly Gly Glu Val 
                325                 330                 335     


Ala Ala Val Lys Arg Ala Leu Leu Leu Leu Val Pro Ala Phe Leu Leu 
            340                 345                 350         


Ile Gly Trp Gly Arg Ser Leu Pro Val Leu Gly Leu Gly Leu Leu Leu 
        355                 360                 365             


Tyr Ser Phe Ala Ala Ala Val Val Val Pro Cys Leu Ser Ser Val Val 
    370                 375                 380                 


Ala Gly Tyr Gly Ser Pro Gly Gln Lys Gly Thr Val Met Gly Thr Leu 
385                 390                 395                 400 


Arg Ser Leu Gly Ala Leu Ala Arg Ala Ala Gly Pro Leu Val Ala Ala 
                405                 410                 415     


Ser Val Tyr Trp Leu Ala Gly Ala Gln Ala Cys Phe Thr Thr Trp Ser 
            420                 425                 430         


Gly Leu Phe Leu Leu Pro Phe Phe Leu Leu Gln Lys Leu Ser Tyr Pro 
        435                 440                 445             


Ala Gln Thr Leu Lys Ala Glu 
    450                 455 


<210>  276
<211>  1067
<212>  PRT
<213>  Homo sapiens

<400>  276

Met Ala Ser Pro Thr Ser Thr Asn Pro Ala His Ala His Phe Glu Ser 
1               5                   10                  15      


Phe Leu Gln Ala Gln Leu Cys Gln Asp Val Leu Ser Ser Phe Gln Glu 
            20                  25                  30          


Leu Cys Gly Ala Leu Gly Leu Glu Pro Gly Gly Gly Leu Pro Gln Tyr 
        35                  40                  45              


His Lys Ile Lys Asp Gln Leu Asn Tyr Trp Ser Ala Lys Ser Leu Trp 
    50                  55                  60                  


Thr Lys Leu Asp Lys Arg Ala Gly Gln Pro Val Tyr Gln Gln Gly Arg 
65                  70                  75                  80  


Ala Cys Thr Ser Thr Lys Cys Leu Val Val Gly Ala Gly Pro Cys Gly 
                85                  90                  95      


Leu Arg Val Ala Val Glu Leu Ala Leu Leu Gly Ala Arg Val Val Leu 
            100                 105                 110         


Val Glu Lys Arg Thr Lys Phe Ser Arg His Asn Val Leu His Leu Trp 
        115                 120                 125             


Pro Phe Thr Ile His Asp Leu Arg Ala Leu Gly Ala Lys Lys Phe Tyr 
    130                 135                 140                 


Gly Arg Phe Cys Thr Gly Thr Leu Asp His Ile Ser Ile Arg Gln Leu 
145                 150                 155                 160 


Gln Leu Leu Leu Leu Lys Val Ala Leu Leu Leu Gly Val Glu Ile His 
                165                 170                 175     


Trp Gly Val Thr Phe Thr Gly Leu Gln Pro Pro Pro Arg Lys Gly Ser 
            180                 185                 190         


Gly Trp Arg Ala Gln Leu Gln Pro Asn Pro Pro Ala Gln Leu Ala Asn 
        195                 200                 205             


Tyr Glu Phe Asp Val Leu Ile Ser Ala Ala Gly Gly Lys Phe Val Pro 
    210                 215                 220                 


Glu Gly Phe Lys Val Arg Glu Met Arg Gly Lys Leu Ala Ile Gly Ile 
225                 230                 235                 240 


Thr Ala Asn Phe Val Asn Gly Arg Thr Val Glu Glu Thr Gln Val Pro 
                245                 250                 255     


Glu Ile Ser Gly Val Ala Arg Ile Tyr Asn Gln Ser Phe Phe Gln Ser 
            260                 265                 270         


Leu Leu Lys Ala Thr Gly Ile Asp Leu Glu Asn Ile Val Tyr Tyr Lys 
        275                 280                 285             


Asp Asp Thr His Tyr Phe Val Met Thr Ala Lys Lys Gln Cys Leu Leu 
    290                 295                 300                 


Arg Leu Gly Val Leu Arg Gln Asp Trp Pro Asp Thr Asn Arg Leu Leu 
305                 310                 315                 320 


Gly Ser Ala Asn Val Val Pro Glu Ala Leu Gln Arg Phe Thr Arg Ala 
                325                 330                 335     


Ala Ala Asp Phe Ala Thr His Gly Lys Leu Gly Lys Leu Glu Phe Ala 
            340                 345                 350         


Gln Asp Ala His Gly Gln Pro Asp Val Ser Ala Phe Asp Phe Thr Ser 
        355                 360                 365             


Met Met Arg Ala Glu Ser Ser Ala Arg Val Gln Glu Lys His Gly Ala 
    370                 375                 380                 


Arg Leu Leu Leu Gly Leu Val Gly Asp Cys Leu Val Glu Pro Phe Trp 
385                 390                 395                 400 


Pro Leu Gly Thr Gly Val Ala Arg Gly Phe Leu Ala Ala Phe Asp Ala 
                405                 410                 415     


Ala Trp Met Val Lys Arg Trp Ala Glu Gly Ala Glu Ser Leu Glu Val 
            420                 425                 430         


Leu Ala Glu Arg Glu Ser Leu Tyr Gln Leu Leu Ser Gln Thr Ser Pro 
        435                 440                 445             


Glu Asn Met His Arg Asn Val Ala Gln Tyr Gly Leu Asp Pro Ala Thr 
    450                 455                 460                 


Arg Tyr Pro Asn Leu Asn Leu Arg Ala Val Thr Pro Asn Gln Val Arg 
465                 470                 475                 480 


Asp Leu Tyr Asp Val Leu Ala Lys Glu Pro Val Gln Arg Asn Asn Asp 
                485                 490                 495     


Lys Thr Asp Thr Gly Met Pro Ala Thr Gly Ser Ala Gly Thr Gln Glu 
            500                 505                 510         


Glu Leu Leu Arg Trp Cys Gln Glu Gln Thr Ala Gly Tyr Pro Gly Val 
        515                 520                 525             


His Val Ser Asp Leu Ser Ser Ser Trp Ala Asp Gly Leu Ala Leu Cys 
    530                 535                 540                 


Ala Leu Val Tyr Arg Leu Gln Pro Gly Leu Leu Glu Pro Ser Glu Leu 
545                 550                 555                 560 


Gln Gly Leu Gly Ala Leu Glu Ala Thr Ala Trp Ala Leu Lys Val Ala 
                565                 570                 575     


Glu Asn Glu Leu Gly Ile Thr Pro Val Val Ser Ala Gln Ala Val Val 
            580                 585                 590         


Ala Gly Ser Asp Pro Leu Gly Leu Ile Ala Tyr Leu Ser His Phe His 
        595                 600                 605             


Ser Ala Phe Lys Ser Met Ala His Ser Pro Gly Pro Val Ser Gln Ala 
    610                 615                 620                 


Ser Pro Gly Thr Ser Ser Ala Val Leu Phe Leu Ser Lys Leu Gln Arg 
625                 630                 635                 640 


Thr Leu Gln Arg Ser Arg Ala Lys Glu Asn Ala Glu Asp Ala Gly Gly 
                645                 650                 655     


Lys Lys Leu Arg Leu Glu Met Glu Ala Glu Thr Pro Ser Thr Glu Val 
            660                 665                 670         


Pro Pro Asp Pro Glu Pro Gly Val Pro Leu Thr Pro Pro Ser Gln His 
        675                 680                 685             


Gln Glu Ala Gly Ala Gly Asp Leu Cys Ala Leu Cys Gly Glu His Leu 
    690                 695                 700                 


Tyr Val Leu Glu Arg Leu Cys Val Asn Gly His Phe Phe His Arg Ser 
705                 710                 715                 720 


Cys Phe Arg Cys His Thr Cys Glu Ala Thr Leu Trp Pro Gly Gly Tyr 
                725                 730                 735     


Glu Gln His Pro Gly Asp Gly His Phe Tyr Cys Leu Gln His Leu Pro 
            740                 745                 750         


Gln Thr Asp His Lys Ala Glu Gly Ser Asp Arg Gly Pro Glu Ser Pro 
        755                 760                 765             


Glu Leu Pro Thr Pro Ser Glu Asn Ser Met Pro Pro Gly Leu Ser Thr 
    770                 775                 780                 


Pro Thr Ala Ser Gln Glu Gly Ala Gly Pro Val Pro Asp Pro Ser Gln 
785                 790                 795                 800 


Pro Thr Arg Arg Gln Ile Arg Leu Ser Ser Pro Glu Arg Gln Arg Leu 
                805                 810                 815     


Ser Ser Leu Asn Leu Thr Pro Asp Pro Glu Met Glu Pro Pro Pro Lys 
            820                 825                 830         


Pro Pro Arg Ser Cys Ser Ala Leu Ala Arg His Ala Leu Glu Ser Ser 
        835                 840                 845             


Phe Val Gly Trp Gly Leu Pro Val Gln Ser Pro Gln Ala Leu Val Ala 
    850                 855                 860                 


Met Glu Lys Glu Glu Lys Glu Ser Pro Phe Ser Ser Glu Glu Glu Glu 
865                 870                 875                 880 


Glu Asp Val Pro Leu Asp Ser Asp Val Glu Gln Ala Leu Gln Thr Phe 
                885                 890                 895     


Ala Lys Thr Ser Gly Thr Met Asn Asn Tyr Pro Thr Trp Arg Arg Thr 
            900                 905                 910         


Leu Leu Arg Arg Ala Lys Glu Glu Glu Met Lys Arg Phe Cys Lys Ala 
        915                 920                 925             


Gln Thr Ile Gln Arg Arg Leu Asn Glu Ile Glu Ala Ala Leu Arg Glu 
    930                 935                 940                 


Leu Glu Ala Glu Gly Val Lys Leu Glu Leu Ala Leu Arg Arg Gln Ser 
945                 950                 955                 960 


Ser Ser Pro Glu Gln Gln Lys Lys Leu Trp Val Gly Gln Leu Leu Gln 
                965                 970                 975     


Leu Val Asp Lys Lys Asn Ser Leu Val Ala Glu Glu Ala Glu Leu Met 
            980                 985                 990         


Ile Thr Val Gln Glu Leu Asn Leu  Glu Glu Lys Gln Trp  Gln Leu Asp 
        995                 1000                 1005             


Gln Glu  Leu Arg Gly Tyr Met  Asn Arg Glu Glu Asn  Leu Lys Thr 
    1010                 1015                 1020             


Ala Ala  Asp Arg Gln Ala Glu  Asp Gln Val Leu Arg  Lys Leu Val 
    1025                 1030                 1035             


Asp Leu  Val Asn Gln Arg Asp  Ala Leu Ile Arg Phe  Gln Glu Glu 
    1040                 1045                 1050             


Arg Arg  Leu Ser Glu Leu Ala  Leu Gly Thr Gly Ala  Gln Gly 
    1055                 1060                 1065         


<210>  277
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Phe Ser Leu Lys Thr Leu Pro Phe Leu Leu Leu Leu His Val Gln 
1               5                   10                  15      


Ile Ser Lys Ala Phe Pro Val Ser Ser Lys Glu Lys Asn Thr Lys Thr 
            20                  25                  30          


Val Gln Asp Tyr Leu Glu Lys Phe Tyr Gln Leu Pro Ser Asn Gln Tyr 
        35                  40                  45              


Gln Ser Thr Arg Lys Asn Gly Thr Asn Val Ile Val Glu Lys Leu Lys 
    50                  55                  60                  


Glu Met Gln Arg Phe Phe Gly Leu Asn Val Thr Gly Lys Pro Asn Glu 
65                  70                  75                  80  


Glu Thr Leu Asp Met Met Lys Lys Pro Arg Cys Gly Val Pro Asp Ser 
                85                  90                  95      


Gly Gly Phe Met Leu Thr Pro Gly Asn Pro Lys Trp Glu Arg Thr Asn 
            100                 105                 110         


Leu Thr Tyr Arg Ile Arg Asn Tyr Thr Pro Gln Leu Ser Glu Ala Glu 
        115                 120                 125             


Val Glu Arg Ala Ile Lys Asp Ala Phe Glu Leu Trp Ser Val Ala Ser 
    130                 135                 140                 


Pro Leu Ile Phe Thr Arg Ile Ser Gln Gly Glu Ala Asp Ile Asn Ile 
145                 150                 155                 160 


Ala Phe Tyr Gln Arg Asp His Gly Asp Asn Ser Pro Phe Asp Gly Pro 
                165                 170                 175     


Asn Gly Ile Leu Ala His Ala Phe Gln Pro Gly Gln Gly Ile Gly Gly 
            180                 185                 190         


Asp Ala His Phe Asp Ala Glu Glu Thr Trp Thr Asn Thr Ser Ala Asn 
        195                 200                 205             


Tyr Asn Leu Phe Leu Val Ala Ala His Glu Phe Gly His Ser Leu Gly 
    210                 215                 220                 


Leu Ala His Ser Ser Asp Pro Gly Ala Leu Met Tyr Pro Asn Tyr Ala 
225                 230                 235                 240 


Phe Arg Glu Thr Ser Asn Tyr Ser Leu Pro Gln Asp Asp Ile Asp Gly 
                245                 250                 255     


Ile Gln Ala Ile Tyr Gly Leu Ser Ser Asn Pro Ile Gln Pro Thr Gly 
            260                 265                 270         


Pro Ser Thr Pro Lys Pro Cys Asp Pro Ser Leu Thr Phe Asp Ala Ile 
        275                 280                 285             


Thr Thr Leu Arg Gly Glu Ile Leu Phe Phe Lys Asp Arg Tyr Phe Trp 
    290                 295                 300                 


Arg Arg His Pro Gln Leu Gln Arg Val Glu Met Asn Phe Ile Ser Leu 
305                 310                 315                 320 


Phe Trp Pro Ser Leu Pro Thr Gly Ile Gln Ala Ala Tyr Glu Asp Phe 
                325                 330                 335     


Asp Arg Asp Leu Ile Phe Leu Phe Lys Gly Asn Gln Tyr Trp Ala Leu 
            340                 345                 350         


Ser Gly Tyr Asp Ile Leu Gln Gly Tyr Pro Lys Asp Ile Ser Asn Tyr 
        355                 360                 365             


Gly Phe Pro Ser Ser Val Gln Ala Ile Asp Ala Ala Val Phe Tyr Arg 
    370                 375                 380                 


Ser Lys Thr Tyr Phe Phe Val Asn Asp Gln Phe Trp Arg Tyr Asp Asn 
385                 390                 395                 400 


Gln Arg Gln Phe Met Glu Pro Gly Tyr Pro Lys Ser Ile Ser Gly Ala 
                405                 410                 415     


Phe Pro Gly Ile Glu Ser Lys Val Asp Ala Val Phe Gln Gln Glu His 
            420                 425                 430         


Phe Phe His Val Phe Ser Gly Pro Arg Tyr Tyr Ala Phe Asp Leu Ile 
        435                 440                 445             


Ala Gln Arg Val Thr Arg Val Ala Arg Gly Asn Lys Trp Leu Asn Cys 
    450                 455                 460                 


Arg Tyr Gly 
465         


<210>  278
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  278

Met Ser Ile Glu Thr Leu Leu Glu Ala Ala Arg Phe Leu Glu Trp Gln 
1               5                   10                  15      


Ala Gln Gln Gln Gln Arg Ala Arg Glu Glu Gln Glu Arg Leu Arg Leu 
            20                  25                  30          


Glu Gln Glu Arg Glu Gln Glu Gln Lys Lys Ala Asn Ser Leu Ala Arg 
        35                  40                  45              


Leu Ala His Thr Leu Pro Val Glu Glu Pro Arg Met Glu Ala Pro Pro 
    50                  55                  60                  


Leu Pro Leu Ser Pro Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Leu 
65                  70                  75                  80  


Ala Thr Pro Ala Pro Leu Thr Val Ile Pro Ile Pro Val Val Thr Asn 
                85                  90                  95      


Ser Pro Gln Pro Leu Pro Pro Pro Pro Pro Leu Pro Ala Ala Ala Gln 
            100                 105                 110         


Pro Leu Pro Leu Ala Pro Arg Gln Pro Ala Leu Val Gly Ala Pro Gly 
        115                 120                 125             


Leu Ser Ile Lys Glu Pro Ala Pro Leu Pro Ser Arg Pro Gln Val Pro 
    130                 135                 140                 


Thr Pro Ala Pro Leu Leu Pro Asp Ser Lys Ala Thr Ile Pro Pro Asn 
145                 150                 155                 160 


Gly Ser Pro Lys Pro Leu Gln Pro Leu Pro Thr Pro Val Leu Thr Ile 
                165                 170                 175     


Ala Pro His Pro Gly Val Gln Pro Gln Leu Ala Pro Gln Gln Pro Pro 
            180                 185                 190         


Pro Pro Thr Leu Gly Thr Leu Lys Leu Ala Pro Ala Glu Glu Val Lys 
        195                 200                 205             


Ser Ser Glu Gln Lys Lys Arg Pro Gly Gly Ile Gly Thr Arg Glu Val 
    210                 215                 220                 


His Asn Lys Leu Glu Lys Asn Arg Arg Ala His Leu Lys Glu Cys Phe 
225                 230                 235                 240 


Glu Thr Leu Lys Arg Asn Ile Pro Asn Val Asp Asp Lys Lys Thr Ser 
                245                 250                 255     


Asn Leu Ser Val Leu Arg Thr Ala Leu Arg Tyr Ile Gln Ser Leu Lys 
            260                 265                 270         


Arg Lys Glu Lys Glu Tyr Glu His Glu Met Glu Arg Leu Ala Arg Glu 
        275                 280                 285             


Lys Ile Ala Thr Gln Gln Arg Leu Ala Glu Leu Lys His Glu Leu Ser 
    290                 295                 300                 


Gln Trp Met Asp Val Leu Glu Ile Asp Arg Val Leu Arg Gln Thr Gly 
305                 310                 315                 320 


Gln Pro Glu Asp Asp Gln Ala Ser Thr Ser Thr Ala Ser Glu Gly Glu 
                325                 330                 335     


Asp Asn Ile Asp Glu Asp Met Glu Glu Asp Arg Ala Gly Leu Gly Pro 
            340                 345                 350         


Pro Lys Leu Ser His Arg Pro Gln Pro Glu Leu Leu Lys Ser Thr Leu 
        355                 360                 365             


Pro Pro Pro Ser Thr Thr Pro Ala Pro Leu Pro Pro His Pro His Pro 
    370                 375                 380                 


His Pro His Ser Val Ala Leu Pro Pro Ala His Leu Pro Val Gln Gln 
385                 390                 395                 400 


Gln Gln Pro Gln Gln Lys Thr Pro Leu Pro Ala Pro Pro Pro Pro Pro 
                405                 410                 415     


Ala Ala Pro Ala Gln Thr Leu Val Pro Ala Pro Ala His Leu Val Ala 
            420                 425                 430         


Thr Ala Gly Gly Gly Ser Thr Val Ile Ala His Thr Ala Thr Thr His 
        435                 440                 445             


Ala Ser Val Ile Gln Thr Val Asn His Val Leu Gln Gly Pro Gly Gly 
    450                 455                 460                 


Lys His Ile Ala His Ile Ala Pro Ser Ala Pro Ser Pro Ala Val Gln 
465                 470                 475                 480 


Leu Ala Pro Ala Thr Pro Pro Ile Gly His Ile Thr Val His Pro Ala 
                485                 490                 495     


Thr Leu Asn His Val Ala His Leu Gly Ser Gln Leu Pro Leu Tyr Pro 
            500                 505                 510         


Gln Pro Val Ala Val Ser His Ile Ala His Thr Leu Ser His Gln Gln 
        515                 520                 525             


Val Asn Gly Thr Ala Gly Leu Gly Pro Pro Ala Thr Val Met Ala Lys 
    530                 535                 540                 


Pro Ala Val Gly Ala Gln Val Val His His Pro Gln Leu Val Gly Gln 
545                 550                 555                 560 


Thr Val Leu Asn Pro Val Thr Met Val Thr Met Pro Ser Phe Pro Val 
                565                 570                 575     


Ser Thr Leu Lys Leu Ala 
            580         


<210>  279
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  279

Met Ala Ala Ser Val Leu Asn Thr Val Leu Arg Arg Leu Pro Met Leu 
1               5                   10                  15      


Ser Leu Phe Arg Gly Ser His Arg Val Gln Val Pro Leu Gln Thr Leu 
            20                  25                  30          


Cys Thr Lys Ala Pro Ser Glu Glu Asp Ser Leu Ser Ser Val Pro Ile 
        35                  40                  45              


Ser Pro Tyr Lys Asp Glu Pro Trp Lys Tyr Leu Glu Ser Glu Glu Tyr 
    50                  55                  60                  


Gln Glu Arg Tyr Gly Ser Arg Pro Val Trp Ala Asp Tyr Arg Arg Asn 
65                  70                  75                  80  


His Lys Gly Gly Val Pro Pro Gln Arg Thr Arg Lys Thr Cys Ile Arg 
                85                  90                  95      


Arg Asn Lys Val Val Gly Asn Pro Cys Pro Ile Cys Arg Asp His Lys 
            100                 105                 110         


Leu His Val Asp Phe Arg Asn Val Lys Leu Leu Glu Gln Phe Val Cys 
        115                 120                 125             


Ala His Thr Gly Ile Ile Phe Tyr Ala Pro Tyr Thr Gly Val Cys Val 
    130                 135                 140                 


Lys Gln His Lys Arg Leu Thr Gln Ala Ile Gln Lys Ala Arg Asp His 
145                 150                 155                 160 


Gly Leu Leu Ile Tyr His Ile Pro Gln Val Glu Pro Arg Asp Leu Asp 
                165                 170                 175     


Phe Ser Thr Ser His Gly Ala Val Ser Ala Thr Pro Pro Ala Pro Thr 
            180                 185                 190         


Leu Val Ser Gly Asp Pro Trp Tyr Pro Trp Tyr Asn Trp Lys Gln Pro 
        195                 200                 205             


Pro Glu Arg Glu Leu Ser Arg Leu Arg Arg Leu Tyr Gln Gly His Leu 
    210                 215                 220                 


Gln Glu Glu Ser Gly Pro Pro Pro Glu Ser Met Pro Lys Met Pro Pro 
225                 230                 235                 240 


Arg Thr Pro Ala Glu Ala Ser Ser Thr Gly Gln Thr Gly Pro Gln Ser 
                245                 250                 255     


Ala Leu 
        


<210>  280
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  281
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  282
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Ser Ser Lys Arg Ala Lys Ala Lys Thr Thr Lys Lys Arg Pro Gln 
1               5                   10                  15      


Arg Ala Thr Ser Asn Val Phe Ala Met Phe Asp Gln Ser Gln Ile Gln 
            20                  25                  30          


Glu Phe Lys Glu Ala Phe Asn Met Ile Asp Gln Asn Arg Asp Gly Phe 
        35                  40                  45              


Ile Asp Lys Glu Asp Leu His Asp Met Leu Ala Ser Leu Gly Lys Asn 
    50                  55                  60                  


Pro Thr Asp Glu Tyr Leu Glu Gly Met Met Ser Glu Ala Pro Gly Pro 
65                  70                  75                  80  


Ile Asn Phe Thr Met Phe Leu Thr Met Phe Gly Glu Lys Leu Asn Gly 
                85                  90                  95      


Thr Asp Pro Glu Asp Val Ile Arg Asn Ala Phe Ala Cys Phe Asp Glu 
            100                 105                 110         


Glu Ala Ser Gly Phe Ile His Glu Asp His Leu Arg Glu Leu Leu Thr 
        115                 120                 125             


Thr Met Gly Asp Arg Phe Thr Asp Glu Glu Val Asp Glu Met Tyr Arg 
    130                 135                 140                 


Glu Ala Pro Ile Asp Lys Lys Gly Asn Phe Asn Tyr Val Glu Phe Thr 
145                 150                 155                 160 


Arg Ile Leu Lys His Gly Ala Lys Asp Lys Asp Asp 
                165                 170         


<210>  283
<211>  1465
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Ser Leu Val Thr Val Pro Phe Tyr Gln Lys Arg His Arg His Phe 
1               5                   10                  15      


Asp Gln Ser Tyr Arg Asn Ile Gln Thr Arg Tyr Leu Leu Asp Glu Tyr 
            20                  25                  30          


Ala Ser Lys Lys Arg Ala Ser Thr Gln Ala Ser Ser Gln Lys Ser Leu 
        35                  40                  45              


Ser Gln Arg Ser Ser Ser Gln Arg Ala Ser Ser Gln Thr Ser Leu Gly 
    50                  55                  60                  


Gly Thr Ile Cys Arg Val Cys Ala Lys Arg Val Ser Thr Gln Glu Asp 
65                  70                  75                  80  


Glu Glu Gln Glu Asn Arg Ser Arg Tyr Gln Ser Leu Val Ala Ala Tyr 
                85                  90                  95      


Gly Glu Ala Lys Arg Gln Arg Phe Leu Ser Glu Leu Ala His Leu Glu 
            100                 105                 110         


Glu Asp Val His Leu Ala Arg Ser Gln Ala Arg Asp Lys Leu Asp Lys 
        115                 120                 125             


Tyr Ala Ile Gln Gln Met Met Glu Asp Lys Leu Ala Trp Glu Arg His 
    130                 135                 140                 


Thr Phe Glu Glu Arg Ile Ser Arg Ala Pro Glu Ile Leu Val Arg Leu 
145                 150                 155                 160 


Arg Ser His Thr Val Trp Glu Arg Met Ser Val Lys Leu Cys Phe Thr 
                165                 170                 175     


Val Gln Gly Phe Pro Thr Pro Val Val Gln Trp Tyr Lys Asp Gly Ser 
            180                 185                 190         


Leu Ile Cys Gln Ala Ala Glu Pro Gly Lys Tyr Arg Ile Glu Ser Asn 
        195                 200                 205             


Tyr Gly Val His Thr Leu Glu Ile Asn Arg Ala Asp Phe Asp Asp Thr 
    210                 215                 220                 


Ala Thr Tyr Ser Ala Val Ala Thr Asn Ala His Gly Gln Val Ser Thr 
225                 230                 235                 240 


Asn Ala Ala Val Val Val Arg Arg Phe Arg Gly Asp Glu Glu Pro Phe 
                245                 250                 255     


Arg Ser Val Gly Leu Pro Ile Gly Leu Pro Leu Ser Ser Met Ile Pro 
            260                 265                 270         


Tyr Thr His Phe Asp Val Gln Phe Leu Glu Lys Phe Gly Val Thr Phe 
        275                 280                 285             


Arg Arg Glu Gly Glu Thr Val Thr Leu Lys Cys Thr Met Leu Val Thr 
    290                 295                 300                 


Pro Asp Leu Lys Arg Val Gln Pro Arg Ala Glu Trp Tyr Arg Asp Asp 
305                 310                 315                 320 


Val Leu Leu Lys Glu Ser Lys Trp Thr Lys Met Phe Phe Gly Glu Gly 
                325                 330                 335     


Gln Ala Ser Leu Ser Phe Ser His Leu His Lys Asp Asp Glu Gly Leu 
            340                 345                 350         


Tyr Thr Leu Arg Ile Val Ser Arg Gly Gly Val Ser Asp His Ser Ala 
        355                 360                 365             


Phe Leu Phe Val Arg Asp Ala Asp Pro Leu Val Thr Gly Ala Pro Gly 
    370                 375                 380                 


Ala Pro Met Asp Leu Gln Cys His Asp Ala Asn Arg Asp Tyr Val Ile 
385                 390                 395                 400 


Val Thr Trp Lys Pro Pro Asn Thr Thr Thr Glu Ser Pro Val Met Gly 
                405                 410                 415     


Tyr Phe Val Asp Arg Cys Glu Val Gly Thr Asn Asn Trp Val Gln Cys 
            420                 425                 430         


Asn Asp Ala Pro Val Lys Ile Cys Lys Tyr Pro Val Thr Gly Leu Phe 
        435                 440                 445             


Glu Gly Arg Ser Tyr Ile Phe Arg Val Arg Ala Val Asn Ser Ala Gly 
    450                 455                 460                 


Ile Ser Arg Pro Ser Arg Val Ser Asp Ala Val Ala Ala Leu Asp Pro 
465                 470                 475                 480 


Leu Asp Leu Arg Arg Leu Gln Ala Val His Leu Glu Gly Glu Lys Glu 
                485                 490                 495     


Ile Ala Ile Tyr Gln Asp Asp Leu Glu Gly Asp Ala Gln Val Pro Gly 
            500                 505                 510         


Pro Pro Thr Gly Val His Ala Ser Glu Ile Ser Arg Asn Tyr Val Val 
        515                 520                 525             


Leu Ser Trp Glu Pro Pro Thr Pro Arg Gly Lys Asp Pro Leu Met Tyr 
    530                 535                 540                 


Phe Ile Glu Lys Ser Val Val Gly Ser Gly Ser Trp Gln Arg Val Asn 
545                 550                 555                 560 


Ala Gln Thr Ala Val Arg Ser Pro Arg Tyr Ala Val Phe Asp Leu Met 
                565                 570                 575     


Glu Gly Lys Ser Tyr Val Phe Arg Val Leu Ser Ala Asn Arg His Gly 
            580                 585                 590         


Leu Ser Glu Pro Ser Glu Ile Thr Ser Pro Ile Gln Ala Gln Asp Val 
        595                 600                 605             


Thr Val Val Pro Ser Ala Pro Gly Arg Val Leu Ala Ser Arg Asn Thr 
    610                 615                 620                 


Lys Thr Ser Val Val Val Gln Trp Asp Arg Pro Lys His Glu Glu Asp 
625                 630                 635                 640 


Leu Leu Gly Tyr Tyr Val Asp Cys Cys Val Ala Gly Thr Asn Leu Trp 
                645                 650                 655     


Glu Pro Cys Asn His Lys Pro Ile Gly Tyr Asn Arg Phe Val Val His 
            660                 665                 670         


Gly Leu Thr Thr Gly Glu Gln Tyr Ile Phe Arg Val Lys Ala Val Asn 
        675                 680                 685             


Ala Val Gly Met Ser Glu Asn Ser Gln Glu Ser Asp Val Ile Lys Val 
    690                 695                 700                 


Gln Ala Ala Leu Thr Val Pro Ser His Pro Tyr Gly Ile Thr Leu Leu 
705                 710                 715                 720 


Asn Cys Asp Gly His Ser Met Thr Leu Gly Trp Lys Val Pro Lys Phe 
                725                 730                 735     


Ser Gly Gly Ser Pro Ile Leu Gly Tyr Tyr Leu Asp Lys Arg Glu Val 
            740                 745                 750         


His His Lys Asn Trp His Glu Val Asn Ser Ser Pro Ser Lys Pro Thr 
        755                 760                 765             


Ile Leu Thr Val Asp Gly Leu Thr Glu Gly Ser Leu Tyr Glu Phe Lys 
    770                 775                 780                 


Ile Ala Ala Val Asn Leu Ala Gly Ile Gly Glu Pro Ser Asp Pro Ser 
785                 790                 795                 800 


Glu His Phe Lys Cys Glu Ala Trp Thr Met Pro Glu Pro Gly Pro Ala 
                805                 810                 815     


Tyr Asp Leu Thr Phe Cys Glu Val Arg Asp Thr Ser Leu Val Met Leu 
            820                 825                 830         


Trp Lys Ala Pro Val Tyr Ser Gly Ser Ser Pro Val Ser Gly Tyr Phe 
        835                 840                 845             


Val Asp Phe Arg Glu Glu Asp Ala Gly Glu Trp Ile Thr Val Asn Gln 
    850                 855                 860                 


Thr Thr Thr Ala Ser Arg Tyr Leu Lys Val Ser Asp Leu Gln Gln Gly 
865                 870                 875                 880 


Lys Thr Tyr Val Phe Arg Val Arg Ala Val Asn Ala Asn Gly Val Gly 
                885                 890                 895     


Lys Pro Ser Asp Thr Ser Glu Pro Val Leu Val Glu Ala Arg Pro Gly 
            900                 905                 910         


Thr Lys Glu Ile Ser Ala Gly Val Asp Glu Gln Gly Asn Ile Tyr Leu 
        915                 920                 925             


Gly Phe Asp Cys Gln Glu Met Thr Asp Ala Ser Gln Phe Thr Trp Cys 
    930                 935                 940                 


Lys Ser Tyr Glu Glu Ile Ser Asp Asp Glu Arg Phe Lys Ile Glu Thr 
945                 950                 955                 960 


Val Gly Asp His Ser Lys Leu Tyr Leu Lys Asn Pro Asp Lys Glu Asp 
                965                 970                 975     


Leu Gly Thr Tyr Ser Val Ser Val Ser Asp Thr Asp Gly Val Ser Ser 
            980                 985                 990         


Ser Phe Val Leu Asp Pro Glu Glu  Leu Glu Arg Leu Met  Ala Leu Ser 
        995                 1000                 1005             


Asn Glu  Ile Lys Asn Pro Thr  Ile Pro Leu Lys Ser  Glu Leu Ala 
    1010                 1015                 1020             


Tyr Glu  Ile Phe Asp Lys Gly  Arg Val Arg Phe Trp  Leu Gln Ala 
    1025                 1030                 1035             


Glu His  Leu Ser Pro Asp Ala  Ser Tyr Arg Phe Ile  Ile Asn Asp 
    1040                 1045                 1050             


Arg Glu  Val Ser Asp Ser Glu  Ile His Arg Ile Lys  Cys Asp Lys 
    1055                 1060                 1065             


Ala Thr  Gly Ile Ile Glu Met  Val Met Asp Arg Phe  Ser Ile Glu 
    1070                 1075                 1080             


Asn Glu  Gly Thr Tyr Thr Val  Gln Ile His Asp Gly  Lys Ala Lys 
    1085                 1090                 1095             


Ser Gln  Ser Ser Leu Val Leu  Ile Gly Asp Ala Phe  Lys Thr Val 
    1100                 1105                 1110             


Leu Glu  Glu Ala Glu Phe Gln  Arg Lys Glu Phe Leu  Arg Lys Gln 
    1115                 1120                 1125             


Gly Pro  His Phe Ala Glu Tyr  Leu His Trp Asp Val  Thr Glu Glu 
    1130                 1135                 1140             


Cys Glu  Val Arg Leu Val Cys  Lys Val Ala Asn Thr  Lys Lys Glu 
    1145                 1150                 1155             


Thr Val  Phe Lys Trp Leu Lys  Asp Asp Val Leu Tyr  Glu Thr Glu 
    1160                 1165                 1170             


Thr Leu  Pro Asn Leu Glu Arg  Gly Ile Cys Glu Leu  Leu Ile Pro 
    1175                 1180                 1185             


Lys Leu  Ser Lys Lys Asp His  Gly Glu Tyr Lys Ala  Thr Leu Lys 
    1190                 1195                 1200             


Asp Asp  Arg Gly Gln Asp Val  Ser Ile Leu Glu Ile  Ala Gly Lys 
    1205                 1210                 1215             


Val Tyr  Asp Asp Met Ile Leu  Ala Met Ser Arg Val  Cys Gly Lys 
    1220                 1225                 1230             


Ser Ala  Ser Pro Leu Lys Val  Leu Cys Thr Pro Glu  Gly Ile Arg 
    1235                 1240                 1245             


Leu Gln  Cys Phe Met Lys Tyr  Phe Thr Asp Glu Met  Lys Val Asn 
    1250                 1255                 1260             


Trp Cys  His Lys Asp Ala Lys  Ile Ser Ser Ser Glu  His Met Arg 
    1265                 1270                 1275             


Ile Gly  Gly Ser Glu Glu Met  Ala Trp Leu Gln Ile  Cys Glu Pro 
    1280                 1285                 1290             


Thr Glu  Lys Asp Lys Gly Lys  Tyr Thr Phe Glu Ile  Phe Asp Gly 
    1295                 1300                 1305             


Lys Asp  Asn His Gln Arg Ser  Leu Asp Leu Ser Gly  Gln Ala Phe 
    1310                 1315                 1320             


Asp Glu  Ala Phe Ala Glu Phe  Gln Gln Phe Lys Ala  Ala Ala Phe 
    1325                 1330                 1335             


Ala Glu  Lys Asn Arg Gly Arg  Leu Ile Gly Gly Leu  Pro Asp Val 
    1340                 1345                 1350             


Val Thr  Ile Met Glu Gly Lys  Thr Leu Asn Leu Thr  Cys Thr Val 
    1355                 1360                 1365             


Phe Gly  Asn Pro Asp Pro Glu  Val Ile Trp Phe Lys  Asn Asp Gln 
    1370                 1375                 1380             


Asp Ile  Gln Leu Ser Glu His  Phe Ser Val Lys Val  Glu Gln Ala 
    1385                 1390                 1395             


Lys Tyr  Val Ser Met Thr Ile  Lys Gly Val Thr Ser  Glu Asp Ser 
    1400                 1405                 1410             


Gly Lys  Tyr Ser Ile Asn Ile  Lys Asn Lys Tyr Gly  Gly Glu Lys 
    1415                 1420                 1425             


Ile Asp  Val Thr Val Ser Val  Tyr Lys His Gly Glu  Lys Ile Pro 
    1430                 1435                 1440             


Asp Met  Ala Pro Pro Gln Gln  Ala Lys Pro Lys Leu  Ile Pro Ala 
    1445                 1450                 1455             


Ser Ala  Ser Ala Ala Gly Gln  
    1460                 1465 


<210>  284
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Arg Thr Arg Thr Gly Ser Gln Leu Ala Ala Arg Glu Val Thr Gly 
1               5                   10                  15      


Ser Gly Ala Val Pro Arg Gln Leu Glu Gly Arg Arg Cys Gln Ala Gly 
            20                  25                  30          


Arg Asp Ala Asn Gly Gly Thr Ser Ser Asp Gly Ser Ser Ser Met Ala 
        35                  40                  45              


Ala Ile Tyr Gly Gly Val Glu Gly Gly Gly Thr Arg Ser Glu Val Leu 
    50                  55                  60                  


Leu Val Ser Glu Asp Gly Lys Ile Leu Ala Glu Ala Asp Gly Leu Ser 
65                  70                  75                  80  


Thr Asn His Trp Leu Ile Gly Thr Asp Lys Cys Val Glu Arg Ile Asn 
                85                  90                  95      


Glu Met Val Asn Arg Ala Lys Arg Lys Ala Gly Val Asp Pro Leu Val 
            100                 105                 110         


Pro Leu Arg Ser Leu Gly Leu Ser Leu Ser Gly Gly Asp Gln Glu Asp 
        115                 120                 125             


Ala Gly Arg Ile Leu Ile Glu Glu Leu Arg Asp Arg Phe Pro Tyr Leu 
    130                 135                 140                 


Ser Glu Ser Tyr Leu Ile Thr Thr Asp Ala Ala Gly Ser Ile Ala Thr 
145                 150                 155                 160 


Ala Thr Pro Asp Gly Gly Val Val Leu Ile Ser Gly Thr Gly Ser Asn 
                165                 170                 175     


Cys Arg Leu Ile Asn Pro Asp Gly Ser Glu Ser Gly Cys Gly Gly Trp 
            180                 185                 190         


Gly His Met Met Gly Asp Glu Gly Ser Ala Tyr Trp Ile Ala His Gln 
        195                 200                 205             


Ala Val Lys Ile Val Phe Asp Ser Ile Asp Asn Leu Glu Ala Ala Pro 
    210                 215                 220                 


His Asp Ile Gly Tyr Val Lys Gln Ala Met Phe His Tyr Phe Gln Val 
225                 230                 235                 240 


Pro Asp Arg Leu Gly Ile Leu Thr His Leu Tyr Arg Asp Phe Asp Lys 
                245                 250                 255     


Cys Arg Phe Ala Gly Phe Cys Arg Lys Ile Ala Glu Gly Ala Gln Gln 
            260                 265                 270         


Gly Asp Pro Leu Ser Arg Tyr Ile Phe Arg Lys Ala Gly Glu Met Leu 
        275                 280                 285             


Gly Arg His Ile Val Ala Val Leu Pro Glu Ile Asp Pro Val Leu Phe 
    290                 295                 300                 


Gln Gly Lys Ile Gly Leu Pro Ile Leu Cys Val Gly Ser Val Trp Lys 
305                 310                 315                 320 


Ser Trp Glu Leu Leu Lys Glu Gly Phe Leu Leu Ala Leu Thr Gln Gly 
                325                 330                 335     


Arg Glu Ile Gln Ala Gln Asn Phe Phe Ser Ser Phe Thr Leu Met Lys 
            340                 345                 350         


Leu Arg His Ser Ser Ala Leu Gly Gly Ala Ser Leu Gly Ala Arg His 
        355                 360                 365             


Ile Gly His Leu Leu Pro Met Asp Tyr Ser Ala Asn Ala Ile Ala Phe 
    370                 375                 380                 


Tyr Ser Tyr Thr Phe Ser 
385                 390 


<210>  285
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Glu Ala Asp Lys Asp Asp Thr Gln Gln Ile Leu Lys Glu His Ser 
1               5                   10                  15      


Pro Asp Glu Phe Ile Lys Asp Glu Gln Asn Lys Gly Leu Ile Asp Glu 
            20                  25                  30          


Ile Thr Lys Lys Asn Ile Gln Leu Lys Lys Glu Ile Gln Lys Leu Glu 
        35                  40                  45              


Thr Glu Leu Gln Glu Ala Thr Lys Glu Phe Gln Ile Lys Glu Asp Ile 
    50                  55                  60                  


Pro Glu Thr Lys Met Lys Phe Leu Ser Val Glu Thr Pro Glu Asn Asp 
65                  70                  75                  80  


Ser Gln Leu Ser Asn Ile Ser Cys Ser Phe Gln Val Ser Ser Lys Val 
                85                  90                  95      


Pro Tyr Glu Ile Gln Lys Gly Gln Ala Leu Ile Thr Phe Glu Lys Glu 
            100                 105                 110         


Glu Val Ala Gln Asn Val Val Ser Met Ser Lys His His Val Gln Ile 
        115                 120                 125             


Lys Asp Val Asn Leu Glu Val Thr Ala Lys Pro Val Pro Leu Asn Ser 
    130                 135                 140                 


Gly Val Arg Phe Gln Val Tyr Val Glu Val Ser Lys Met Lys Ile Asn 
145                 150                 155                 160 


Val Thr Glu Ile Pro Asp Thr Leu Arg Glu Asp Gln Met Arg Asp Lys 
                165                 170                 175     


Leu Glu Leu Ser Phe Ser Lys Ser Arg Asn Gly Gly Gly Glu Val Asp 
            180                 185                 190         


Arg Val Asp Tyr Asp Arg Gln Ser Gly Ser Ala Val Ile Thr Phe Val 
        195                 200                 205             


Glu Ile Gly Val Ala Asp Lys Ile Leu Lys Lys Lys Glu Tyr Pro Leu 
    210                 215                 220                 


Tyr Ile Asn Gln Thr Cys His Arg Val Thr Val Ser Pro Tyr Thr Glu 
225                 230                 235                 240 


Ile His Leu Lys Lys Tyr Gln Ile Phe Ser Gly Thr Ser Lys Arg Thr 
                245                 250                 255     


Val Leu Leu Thr Gly Met Glu Gly Ile Gln Met Asp Glu Glu Ile Val 
            260                 265                 270         


Glu Asp Leu Ile Asn Ile His Phe Gln Arg Ala Lys Asn Gly Gly Gly 
        275                 280                 285             


Glu Val Asp Val Val Lys Cys Ser Leu Gly Gln Pro His Ile Ala Tyr 
    290                 295                 300                 


Phe Glu Glu 
305         


<210>  286
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Ala Ile Cys Gln Phe Phe Leu Gln Gly Arg Cys Arg Phe Gly Asp 
1               5                   10                  15      


Arg Cys Trp Asn Glu His Pro Gly Ala Arg Gly Ala Gly Gly Gly Arg 
            20                  25                  30          


Gln Gln Pro Gln Gln Gln Pro Ser Gly Asn Asn Arg Arg Gly Trp Asn 
        35                  40                  45              


Thr Thr Ser Gln Arg Tyr Ser Asn Val Ile Gln Pro Ser Ser Phe Ser 
    50                  55                  60                  


Lys Ser Thr Pro Trp Gly Gly Ser Arg Asp Gln Glu Lys Pro Tyr Phe 
65                  70                  75                  80  


Ser Ser Phe Asp Ser Gly Ala Ser Thr Asn Arg Lys Glu Gly Phe Gly 
                85                  90                  95      


Leu Ser Glu Asn Pro Phe Ala Ser Leu Ser Pro Asp Glu Gln Lys Asp 
            100                 105                 110         


Glu Lys Lys Leu Leu Glu Gly Ile Val Lys Asp Met Glu Val Trp Glu 
        115                 120                 125             


Ser Ser Gly Gln Trp Met Phe Ser Val Tyr Ser Pro Val Lys Lys Lys 
    130                 135                 140                 


Pro Asn Ile Ser Gly Phe Thr Asp Ile Ser Pro Glu Glu Leu Arg Leu 
145                 150                 155                 160 


Glu Tyr His Asn Phe Leu Thr Ser Asn Asn Leu Gln Ser Tyr Leu Asn 
                165                 170                 175     


Ser Val Gln Arg Leu Ile Asn Gln Trp Arg Asn Arg Val Asn Glu Leu 
            180                 185                 190         


Lys Ser Leu Asn Ile Ser Thr Lys Val Ala Leu Leu Ser Asp Val Lys 
        195                 200                 205             


Asp Gly Val Asn Gln Ala Ala Pro Ala Phe Gly Phe Gly Ser Ser Gln 
    210                 215                 220                 


Ala Ala Thr Phe Met Ser Pro Gly Phe Pro Val Asn Asn Ser Ser Ser 
225                 230                 235                 240 


Asp Asn Ala Gln Asn Phe Ser Phe Lys Thr Asn Ser Gly Phe Ala Ala 
                245                 250                 255     


Ala Ser Ser Gly Ser Pro Ala Gly Phe Gly Ser Ser Pro Ala Phe Gly 
            260                 265                 270         


Ala Ala Ala Ser Thr Ser Ser Gly Ile Ser Thr Ser Ala Pro Ala Phe 
        275                 280                 285             


Gly Phe Gly Lys Pro Glu Val Thr Ser Ala Ala Ser Phe Ser Phe Lys 
    290                 295                 300                 


Ser Pro Ala Ala Ser Ser Phe Gly Ser Pro Gly Phe Ser Gly Leu Pro 
305                 310                 315                 320 


Ala Ser Leu Ala Thr Gly Pro Val Arg Ala Pro Val Ala Pro Ala Phe 
                325                 330                 335     


Gly Gly Gly Ser Ser Val Ala Gly Phe Gly Ser Pro Gly Ser His Ser 
            340                 345                 350         


His Thr Ala Phe Ser Lys Pro Ser Ser Asp Thr Phe Gly Asn Ser Ser 
        355                 360                 365             


Ile Ser Thr Ser Leu Ser Ala Ser Ser Ser Ile Ile Ala Thr Asp Asn 
    370                 375                 380                 


Val Leu Phe Thr Pro Arg Asp Lys Leu Thr Val Glu Glu Leu Glu Gln 
385                 390                 395                 400 


Phe Gln Ser Lys Lys Phe Thr Leu Gly Lys Ile Pro Leu Lys Pro Pro 
                405                 410                 415     


Pro Leu Glu Leu Leu Asn Val 
            420             


<210>  287
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Gln Pro Gly Ser Ser Arg Cys Glu Glu Glu Thr Pro Ser Leu Leu 
1               5                   10                  15      


Trp Gly Leu Asp Pro Val Phe Leu Ala Phe Ala Lys Leu Tyr Ile Arg 
            20                  25                  30          


Asp Ile Leu Asp Met Lys Glu Ser Arg Gln Val Pro Gly Val Phe Leu 
        35                  40                  45              


Tyr Asn Gly His Pro Ile Lys Gln Val Asp Val Leu Gly Thr Val Ile 
    50                  55                  60                  


Gly Val Arg Glu Arg Asp Ala Phe Tyr Ser Tyr Gly Val Asp Asp Ser 
65                  70                  75                  80  


Thr Gly Val Ile Asn Cys Ile Cys Trp Lys Lys Leu Asn Thr Glu Ser 
                85                  90                  95      


Val Ser Ala Ala Pro Ser Ala Ala Arg Glu Leu Ser Leu Thr Ser Gln 
            100                 105                 110         


Leu Lys Lys Leu Gln Glu Thr Ile Glu Gln Lys Thr Lys Ile Glu Ile 
        115                 120                 125             


Gly Asp Thr Ile Arg Val Arg Gly Ser Ile Arg Thr Tyr Arg Glu Glu 
    130                 135                 140                 


Arg Glu Ile His Ala Thr Thr Tyr Tyr Lys Val Asp Asp Pro Val Trp 
145                 150                 155                 160 


Asn Ile Gln Ile Ala Arg Met Leu Glu Leu Pro Thr Ile Tyr Arg Lys 
                165                 170                 175     


Val Tyr Asp Gln Pro Phe His Ser Ser Ala Leu Glu Lys Glu Glu Ala 
            180                 185                 190         


Leu Ser Asn Pro Gly Ala Leu Asp Leu Pro Ser Leu Thr Ser Leu Leu 
        195                 200                 205             


Ser Glu Lys Ala Lys Glu Phe Leu Met Glu Asn Arg Val Gln Ser Phe 
    210                 215                 220                 


Tyr Gln Gln Glu Leu Glu Met Val Glu Ser Leu Leu Ser Leu Ala Asn 
225                 230                 235                 240 


Gln Pro Val Ile His Ser Ala Ser Ser Asp Gln Val Asn Phe Lys Lys 
                245                 250                 255     


Asp Thr Thr Ser Lys Ala Ile His Ser Ile Phe Lys Asn Ala Ile Gln 
            260                 265                 270         


Leu Leu Gln Glu Lys Gly Leu Val Phe Gln Lys Asp Asp Gly Phe Asp 
        275                 280                 285             


Asn Leu Tyr Tyr Val Thr Arg Glu Asp Lys Asp Leu His Arg Lys Ile 
    290                 295                 300                 


His Arg Ile Ile Gln Gln Asp Cys Gln Lys Pro Asn His Met Glu Lys 
305                 310                 315                 320 


Gly Cys His Phe Leu His Ile Leu Ala Cys Ala Arg Leu Ser Ile Arg 
                325                 330                 335     


Pro Gly Leu Ser Glu Ala Val Leu Gln Gln Val Leu Glu Leu Leu Glu 
            340                 345                 350         


Asp Gln Ser Asp Ile Val Ser Thr Met Glu His Tyr Tyr Thr Ala Phe 
        355                 360                 365             


<210>  288
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Ala Ser Ile Met Glu Gly Pro Leu Ser Lys Trp Thr Asn Val Met 
1               5                   10                  15      


Lys Gly Trp Gln Tyr Arg Trp Phe Val Leu Asp Tyr Asn Ala Gly Leu 
            20                  25                  30          


Leu Ser Tyr Tyr Thr Ser Lys Asp Lys Met Met Arg Gly Ser Arg Arg 
        35                  40                  45              


Gly Cys Val Arg Leu Arg Gly Ala Val Ile Gly Ile Asp Asp Glu Asp 
    50                  55                  60                  


Asp Ser Thr Phe Thr Ile Thr Val Asp Gln Lys Thr Phe His Phe Gln 
65                  70                  75                  80  


Ala Arg Asp Ala Asp Glu Arg Glu Lys Trp Ile His Ala Leu Glu Glu 
                85                  90                  95      


Thr Ile Leu Arg His Thr Leu Gln Leu Gln Gly Leu Asp Ser Gly Phe 
            100                 105                 110         


Val Pro Ser Val Gln Asp Phe Asp Lys Lys Leu Thr Glu Ala Asp Ala 
        115                 120                 125             


Tyr Leu Gln Ile Leu Ile Glu Gln Leu Lys Leu Phe Asp Asp Lys Leu 
    130                 135                 140                 


Gln Asn Cys Lys Glu Asp Glu Gln Arg Lys Lys Ile Glu Thr Leu Lys 
145                 150                 155                 160 


Glu Thr Thr Asn Ser Met Val Glu Ser Ile Lys His Cys Ile Val Leu 
                165                 170                 175     


Leu Gln Ile Ala Lys Asp Gln Ser Asn Ala Glu Lys His Ala Asp Gly 
            180                 185                 190         


Met Ile Ser Thr Ile Asn Pro Val Asp Ala Ile Tyr Gln Pro Ser Pro 
        195                 200                 205             


Leu Glu Pro Val Ile Ser Thr Met Pro Ser Gln Thr Val Leu Pro Pro 
    210                 215                 220                 


Glu Pro Val Gln Leu Cys Lys Ser Glu Gln Arg Pro Ser Ser Leu Pro 
225                 230                 235                 240 


Val Gly Pro Val Leu Ala Thr Leu Gly His His Gln Thr Pro Thr Pro 
                245                 250                 255     


Asn Ser Thr Gly Ser Gly His Ser Pro Pro Ser Ser Ser Leu Thr Ser 
            260                 265                 270         


Pro Ser His Val Asn Leu Ser Pro Asn Thr Val Pro Glu Phe Ser Tyr 
        275                 280                 285             


Ser Ser Ser Glu Asp Glu Phe Tyr Asp Ala Asp Glu Phe His Gln Ser 
    290                 295                 300                 


Gly Ser Ser Pro Lys Arg Leu Ile Asp Ser Ser Gly Ser Ala Ser Val 
305                 310                 315                 320 


Leu Thr His Ser Ser Ser Gly Asn Ser Leu Lys Arg Pro Asp Thr Thr 
                325                 330                 335     


Glu Ser Leu Asn Ser Ser Leu Ser Asn Gly Thr Ser Asp Ala Asp Leu 
            340                 345                 350         


Phe Asp Ser His Asp Asp Arg Asp Asp Asp Ala Glu Ala Gly Ser Val 
        355                 360                 365             


Glu Glu His Lys Ser Val Ile Met His Leu Leu Ser Gln Val Arg Leu 
    370                 375                 380                 


Gly Met Asp Leu Thr Lys Val Val Leu Pro Thr Phe Ile Leu Glu Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Glu Met Tyr Ala Asp Phe Phe Ala His Pro Asp Leu 
                405                 410                 415     


Phe Val Ser Ile Ser Asp Gln Lys Asp Pro Lys Asp Arg Met Val Gln 
            420                 425                 430         


Val Val Lys Trp Tyr Leu Ser Ala Phe His Ala Gly Arg Lys Gly Ser 
        435                 440                 445             


Val Ala Lys Lys Pro Tyr Asn Pro Ile Leu Gly Glu Ile Phe Gln Cys 
    450                 455                 460                 


His Trp Thr Leu Pro Asn Asp Thr Glu Glu Asn Thr Glu Leu Val Ser 
465                 470                 475                 480 


Glu Gly Pro Val Pro Trp Val Ser Lys Asn Ser Val Thr Phe Val Ala 
                485                 490                 495     


Glu Gln Val Ser His His Pro Pro Ile Ser Ala Phe Tyr Ala Glu Cys 
            500                 505                 510         


Phe Asn Lys Lys Ile Gln Phe Asn Ala His Ile Trp Thr Lys Ser Lys 
        515                 520                 525             


Phe Leu Gly Met Ser Ile Gly Val His Asn Ile Gly Gln Gly Cys Val 
    530                 535                 540                 


Ser Cys Leu Asp Tyr Asp Glu His Tyr Ile Leu Thr Phe Pro Asn Gly 
545                 550                 555                 560 


Tyr Gly Arg Ser Ile Leu Thr Val Pro Trp Val Glu Leu Gly Gly Glu 
                565                 570                 575     


Cys Asn Ile Asn Cys Ser Lys Thr Gly Tyr Ser Ala Asn Ile Ile Phe 
            580                 585                 590         


His Thr Lys Pro Phe Tyr Gly Gly Lys Lys His Arg Ile Thr Ala Glu 
        595                 600                 605             


Ile Phe Ser Pro Asn Asp Lys Lys Ser Phe Cys Ser Ile Glu Gly Glu 
    610                 615                 620                 


Trp Asn Gly Val Met Tyr Ala Lys Tyr Ala Thr Gly Glu Asn Thr Val 
625                 630                 635                 640 


Phe Val Asp Thr Lys Lys Leu Pro Ile Ile Lys Lys Lys Val Arg Lys 
                645                 650                 655     


Leu Glu Asp Gln Asn Glu Tyr Glu Ser Arg Ser Leu Trp Lys Asp Val 
            660                 665                 670         


Thr Phe Asn Leu Lys Ile Arg Asp Ile Asp Ala Ala Thr Glu Ala Lys 
        675                 680                 685             


His Arg Leu Glu Glu Arg Gln Arg Ala Glu Ala Arg Glu Arg Lys Glu 
    690                 695                 700                 


Lys Glu Ile Gln Trp Glu Thr Arg Leu Phe His Glu Asp Gly Glu Cys 
705                 710                 715                 720 


Trp Val Tyr Asp Glu Pro Leu Leu Lys Arg Leu Gly Ala Ala Lys His 
                725                 730                 735     


<210>  289
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val Thr Gly Pro His 
1               5                   10                  15      


Leu Val Gly Cys Gly Asp Val Met Glu Gly Gln Asn Leu Gln Gly Ser 
            20                  25                  30          


Phe Phe Arg Leu Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu 
        35                  40                  45              


Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr Gly Leu Ala Glu 
    50                  55                  60                  


Tyr Leu Gln Phe Asn Lys Arg Cys Gly Gly Leu Leu Phe Asn Leu Ala 
65                  70                  75                  80  


Val Gly Ser Cys Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr 
                85                  90                  95      


Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His Gly Leu Gly Ala 
            100                 105                 110         


Phe Arg Thr Leu Tyr Ser Ala Phe Cys Met Glu Leu Ala Ser Arg Gly 
        115                 120                 125             


Phe Val Val Ala Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr 
    130                 135                 140                 


Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro Thr Asn Glu Ser 
145                 150                 155                 160 


Leu Gln Glu Glu Trp Ile Pro Phe Arg Arg Val Glu Glu Gly Glu Lys 
                165                 170                 175     


Glu Phe His Val Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys 
            180                 185                 190         


Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala Gly Gln Thr Val 
        195                 200                 205             


Phe Asn Ile Leu Pro Gly Gly Leu Asp Leu Met Thr Leu Lys Gly Asn 
    210                 215                 220                 


Ile Asp Met Ser Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala 
225                 230                 235                 240 


Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe Arg Cys Ala Val 
                245                 250                 255     


Ala Leu Asp Ala Trp Met Phe Pro Leu Glu Arg Asp Phe Tyr Pro Lys 
            260                 265                 270         


Ala Arg Gly Pro Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met 
        275                 280                 285             


Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln His Glu Gln Ser 
    290                 295                 300                 


Arg Ile Ile Thr Val Leu Gly Ser Val His Arg Ser Gln Thr Asp Phe 
305                 310                 315                 320 


Ala Phe Val Thr Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr 
                325                 330                 335     


Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val Met Val Arg Ala 
            340                 345                 350         


Met Leu Ala Phe Leu Gln Lys His Leu Asp Leu Lys Glu Asp Tyr Asn 
        355                 360                 365             


Gln Trp Asn Asn Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly 
    370                 375                 380                 


Ala Pro His His Leu Ser Ser Leu 
385                 390         


<210>  290
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Ala Trp Arg Gly Trp Ala Gln Arg Gly Trp Gly Cys Gly Gln Ala 
1               5                   10                  15      


Trp Gly Ala Ser Val Gly Gly Arg Ser Cys Glu Glu Leu Thr Ala Val 
            20                  25                  30          


Leu Thr Pro Pro Gln Leu Leu Gly Arg Arg Phe Asn Phe Phe Ile Gln 
        35                  40                  45              


Gln Lys Cys Gly Phe Arg Lys Ala Pro Arg Lys Val Glu Pro Arg Arg 
    50                  55                  60                  


Ser Asp Pro Gly Thr Ser Gly Glu Ala Tyr Lys Arg Ser Ala Leu Ile 
65                  70                  75                  80  


Pro Pro Val Glu Glu Thr Val Phe Tyr Pro Ser Pro Tyr Pro Ile Arg 
                85                  90                  95      


Ser Leu Ile Lys Pro Leu Phe Phe Thr Val Gly Phe Thr Gly Cys Ala 
            100                 105                 110         


Phe Gly Ser Ala Ala Ile Trp Gln Tyr Glu Ser Leu Lys Ser Arg Val 
        115                 120                 125             


Gln Ser Tyr Phe Asp Gly Ile Lys Ala Asp Trp Leu Asp Ser Ile Arg 
    130                 135                 140                 


Pro Gln Lys Glu Gly Asp Phe Arg Lys Glu Ile Asn Lys Trp Trp Asn 
145                 150                 155                 160 


Asn Leu Ser Asp Gly Gln Arg Thr Val Thr Gly Ile Ile Ala Ala Asn 
                165                 170                 175     


Val Leu Val Phe Cys Leu Trp Arg Val Pro Ser Leu Gln Arg Thr Met 
            180                 185                 190         


Ile Arg Tyr Phe Thr Ser Asn Pro Ala Ser Lys Val Leu Cys Ser Pro 
        195                 200                 205             


Met Leu Leu Ser Thr Phe Ser His Phe Ser Leu Phe His Met Ala Ala 
    210                 215                 220                 


Asn Met Tyr Val Leu Trp Ser Phe Ser Ser Ser Ile Val Asn Ile Leu 
225                 230                 235                 240 


Gly Gln Glu Gln Phe Met Ala Val Tyr Leu Ser Ala Gly Val Ile Ser 
                245                 250                 255     


Asn Phe Val Ser Tyr Val Gly Lys Val Ala Thr Gly Arg Tyr Gly Pro 
            260                 265                 270         


Ser Leu Gly Ala Ser Gly Ala Ile Met Thr Val Leu Ala Ala Val Cys 
        275                 280                 285             


Thr Lys Ile Pro Glu Gly Arg Leu Ala Ile Ile Phe Leu Pro Met Phe 
    290                 295                 300                 


Thr Phe Thr Ala Gly Asn Ala Leu Lys Ala Ile Ile Ala Met Asp Thr 
305                 310                 315                 320 


Ala Gly Met Ile Leu Gly Trp Lys Phe Phe Asp His Ala Ala His Leu 
                325                 330                 335     


Gly Gly Ala Leu Phe Gly Ile Trp Tyr Val Thr Tyr Gly His Glu Leu 
            340                 345                 350         


Ile Trp Lys Asn Arg Glu Pro Leu Val Lys Ile Trp His Glu Ile Arg 
        355                 360                 365             


Thr Asn Gly Pro Lys Lys Gly Gly Gly Ser Lys 
    370                 375                 


<210>  291
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Ala Asp Glu Glu Leu Glu Ala Leu Arg Arg Gln Arg Leu Ala Glu 
1               5                   10                  15      


Leu Gln Ala Lys His Gly Asp Pro Gly Asp Ala Ala Gln Gln Glu Ala 
            20                  25                  30          


Lys His Arg Glu Ala Glu Met Arg Asn Ser Ile Leu Ala Gln Val Leu 
        35                  40                  45              


Asp Gln Ser Ala Arg Ala Arg Leu Ser Asn Leu Ala Leu Val Lys Pro 
    50                  55                  60                  


Glu Lys Thr Lys Ala Val Glu Asn Tyr Leu Ile Gln Met Ala Arg Tyr 
65                  70                  75                  80  


Gly Gln Leu Ser Glu Lys Val Ser Glu Gln Gly Leu Ile Glu Ile Leu 
                85                  90                  95      


Lys Lys Val Ser Gln Gln Thr Glu Lys Thr Thr Thr Val Lys Phe Asn 
            100                 105                 110         


Arg Arg Lys Val Met Asp Ser Asp Glu Asp Asp Asp Tyr 
        115                 120                 125 


<210>  292
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln 
1               5                   10                  15      


Arg Gln Gly Thr Gln Ala Glu Ser Asn Leu Ser Ser Lys Phe Gln Phe 
            20                  25                  30          


Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln His Glu Arg 
        35                  40                  45              


Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro 
    50                  55                  60                  


His Thr Tyr Pro Arg Asn Thr Val Leu Val Trp Arg Leu Val Ala Val 
65                  70                  75                  80  


Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu 
                85                  90                  95      


Glu Asp Pro Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu 
            100                 105                 110         


Glu Pro Ser Asp Gly Thr Ile Leu Gly Arg Trp Cys Gly Ser Gly Thr 
        115                 120                 125             


Val Pro Gly Lys Gln Ile Ser Lys Gly Asn Gln Ile Arg Ile Arg Phe 
    130                 135                 140                 


Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr 
145                 150                 155                 160 


Asn Ile Val Met Pro Gln Phe Thr Glu Ala Val Ser Pro Ser Val Leu 
                165                 170                 175     


Pro Pro Ser Ala Leu Pro Leu Asp Leu Leu Asn Asn Ala Ile Thr Ala 
            180                 185                 190         


Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp 
        195                 200                 205             


Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Thr Trp Gln Leu Leu Gly 
    210                 215                 220                 


Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu 
225                 230                 235                 240 


Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser 
                245                 250                 255     


Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro 
            260                 265                 270         


Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu 
        275                 280                 285             


His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys 
    290                 295                 300                 


Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr Gly Val Arg Gly Leu 
305                 310                 315                 320 


His Lys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp 
                325                 330                 335     


Cys Val Cys Arg Gly Ser Thr Gly Gly 
            340                 345 


<210>  293
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Ala Ala Lys Val Phe Glu Ser Ile Gly Lys Phe Gly Leu Ala Leu 
1               5                   10                  15      


Ala Val Ala Gly Gly Val Val Asn Ser Ala Leu Tyr Asn Val Asp Ala 
            20                  25                  30          


Gly His Arg Ala Val Ile Phe Asp Arg Phe Arg Gly Val Gln Asp Ile 
        35                  40                  45              


Val Val Gly Glu Gly Thr His Phe Leu Ile Pro Trp Val Gln Lys Pro 
    50                  55                  60                  


Ile Ile Phe Asp Cys Arg Ser Arg Pro Arg Asn Val Pro Val Ile Thr 
65                  70                  75                  80  


Gly Ser Lys Asp Leu Gln Asn Val Asn Ile Thr Leu Arg Ile Leu Phe 
                85                  90                  95      


Arg Pro Val Ala Ser Gln Leu Pro Arg Ile Phe Thr Ser Ile Gly Glu 
            100                 105                 110         


Asp Tyr Asp Glu Arg Val Leu Pro Ser Ile Thr Thr Glu Ile Leu Lys 
        115                 120                 125             


Ser Val Val Ala Arg Phe Asp Ala Gly Glu Leu Ile Thr Gln Arg Glu 
    130                 135                 140                 


Leu Val Ser Arg Gln Val Ser Asp Asp Leu Thr Glu Arg Ala Ala Thr 
145                 150                 155                 160 


Phe Gly Leu Ile Leu Asp Asp Val Ser Leu Thr His Leu Thr Phe Gly 
                165                 170                 175     


Lys Glu Phe Thr Glu Ala Val Glu Ala Lys Gln Val Ala Gln Gln Glu 
            180                 185                 190         


Ala Glu Arg Ala Arg Phe Val Val Glu Lys Ala Glu Gln Gln Lys Lys 
        195                 200                 205             


Ala Ala Ile Ile Ser Ala Glu Gly Asp Ser Lys Ala Ala Glu Leu Ile 
    210                 215                 220                 


Ala Asn Ser Leu Ala Thr Ala Gly Asp Gly Leu Ile Glu Leu Arg Lys 
225                 230                 235                 240 


Leu Glu Ala Ala Glu Asp Ile Ala Tyr Gln Leu Ser Arg Ser Arg Asn 
                245                 250                 255     


Ile Thr Tyr Leu Pro Ala Gly Gln Ser Val Leu Leu Gln Leu Pro Gln 
            260                 265                 270         


<210>  294
<211>  2039
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Asp Ile Val Asp Thr Phe Asn His Leu Ile Pro Thr Glu His Leu 
1               5                   10                  15      


Asp Asp Ala Leu Phe Leu Gly Ser Asn Leu Glu Asn Glu Val Cys Glu 
            20                  25                  30          


Asp Phe Ser Ala Ser Gln Asn Val Leu Glu Asp Ser Leu Lys Asn Met 
        35                  40                  45              


Leu Ser Asp Lys Asp Pro Met Leu Gly Ser Ala Ser Asn Gln Phe Cys 
    50                  55                  60                  


Leu Pro Val Leu Asp Ser Asn Asp Pro Asn Phe Gln Met Pro Cys Ser 
65                  70                  75                  80  


Thr Val Val Gly Leu Asp Asp Ile Met Asp Glu Gly Val Val Lys Glu 
                85                  90                  95      


Ser Gly Asn Asp Thr Ile Asp Glu Glu Glu Leu Ile Leu Pro Asn Arg 
            100                 105                 110         


Asn Leu Arg Asp Lys Val Glu Glu Asn Ser Val Arg Ser Pro Arg Lys 
        115                 120                 125             


Ser Pro Arg Leu Met Ala Gln Glu Gln Val Arg Ser Leu Arg Gln Ser 
    130                 135                 140                 


Thr Ile Ala Lys Arg Ser Asn Ala Ala Pro Leu Ser Asn Thr Lys Lys 
145                 150                 155                 160 


Ala Ser Gly Lys Thr Val Ser Thr Ala Lys Ala Gly Val Lys Gln Pro 
                165                 170                 175     


Glu Arg Ser Gln Val Lys Glu Glu Val Cys Met Ser Leu Lys Pro Glu 
            180                 185                 190         


Tyr His Lys Glu Asn Arg Arg Cys Ser Arg Asn Ser Gly Gln Ile Glu 
        195                 200                 205             


Val Val Pro Glu Val Ser Val Ser Ser Ser His Ser Ser Val Ser Ser 
    210                 215                 220                 


Cys Leu Glu Met Lys Asp Glu Asp Gly Leu Asp Ser Lys His Lys Cys 
225                 230                 235                 240 


Asn Asn Pro Gly Glu Ile Asp Val Pro Ser His Glu Leu Asn Cys Ser 
                245                 250                 255     


Leu Leu Ser Glu Thr Cys Val Thr Ile Gly Glu Lys Lys Asn Glu Ala 
            260                 265                 270         


Leu Met Glu Cys Lys Ala Lys Pro Val Gly Ser Pro Leu Phe Lys Phe 
        275                 280                 285             


Ser Asp Lys Glu Glu His Glu Gln Asn Asp Ser Ile Ser Gly Lys Thr 
    290                 295                 300                 


Gly Glu Thr Val Val Glu Glu Met Ile Ala Thr Arg Lys Val Glu Gln 
305                 310                 315                 320 


Asp Ser Lys Glu Thr Val Lys Leu Ser His Glu Asp Asp His Ile Leu 
                325                 330                 335     


Glu Asp Ala Gly Ser Ser Asp Ile Ser Ser Asp Ala Ala Cys Thr Asn 
            340                 345                 350         


Pro Asn Lys Thr Glu Asn Ser Leu Val Gly Leu Pro Ser Cys Val Asp 
        355                 360                 365             


Glu Val Thr Glu Cys Asn Leu Glu Leu Lys Asp Thr Met Gly Ile Ala 
    370                 375                 380                 


Asp Lys Thr Glu Asn Thr Leu Glu Arg Asn Lys Ile Glu Pro Leu Gly 
385                 390                 395                 400 


Tyr Cys Glu Asp Ala Glu Ser Asn Arg Gln Leu Glu Ser Thr Glu Phe 
                405                 410                 415     


Asn Lys Ser Asn Leu Glu Val Val Asp Thr Ser Thr Phe Gly Pro Glu 
            420                 425                 430         


Ser Asn Ile Leu Glu Asn Ala Ile Cys Asp Val Pro Asp Gln Asn Ser 
        435                 440                 445             


Lys Gln Leu Asn Ala Ile Glu Ser Thr Lys Ile Glu Ser His Glu Thr 
    450                 455                 460                 


Ala Asn Leu Gln Asp Asp Arg Asn Ser Gln Ser Ser Ser Val Ser Tyr 
465                 470                 475                 480 


Leu Glu Ser Lys Ser Val Lys Ser Lys His Thr Lys Pro Val Ile His 
                485                 490                 495     


Ser Lys Gln Asn Met Thr Thr Asp Ala Pro Lys Lys Ile Val Ala Ala 
            500                 505                 510         


Lys Tyr Glu Val Ile His Ser Lys Thr Lys Val Asn Val Lys Ser Val 
        515                 520                 525             


Lys Arg Asn Thr Asp Val Pro Glu Ser Gln Gln Asn Phe His Arg Pro 
    530                 535                 540                 


Val Lys Val Arg Lys Lys Gln Ile Asp Lys Glu Pro Lys Ile Gln Ser 
545                 550                 555                 560 


Cys Asn Ser Gly Val Lys Ser Val Lys Asn Gln Ala His Ser Val Leu 
                565                 570                 575     


Lys Lys Thr Leu Gln Asp Gln Thr Leu Val Gln Ile Phe Lys Pro Leu 
            580                 585                 590         


Thr His Ser Leu Ser Asp Lys Ser His Ala His Pro Gly Cys Leu Lys 
        595                 600                 605             


Glu Pro His His Pro Ala Gln Thr Gly His Val Ser His Ser Ser Gln 
    610                 615                 620                 


Lys Gln Cys His Lys Pro Gln Gln Gln Ala Pro Ala Met Lys Thr Asn 
625                 630                 635                 640 


Ser His Val Lys Glu Glu Leu Glu His Pro Gly Val Glu His Phe Lys 
                645                 650                 655     


Glu Glu Asp Lys Leu Lys Leu Lys Lys Pro Glu Lys Asn Leu Gln Pro 
            660                 665                 670         


Arg Gln Arg Arg Ser Ser Lys Ser Phe Ser Leu Asp Glu Pro Pro Leu 
        675                 680                 685             


Phe Ile Pro Asp Asn Ile Ala Thr Ile Arg Arg Glu Gly Ser Asp His 
    690                 695                 700                 


Ser Ser Ser Phe Glu Ser Lys Tyr Met Trp Thr Pro Ser Lys Gln Cys 
705                 710                 715                 720 


Gly Phe Cys Lys Lys Pro His Gly Asn Arg Phe Met Val Gly Cys Gly 
                725                 730                 735     


Arg Cys Asp Asp Trp Phe His Gly Asp Cys Val Gly Leu Ser Leu Ser 
            740                 745                 750         


Gln Ala Gln Gln Met Gly Glu Glu Asp Lys Glu Tyr Val Cys Val Lys 
        755                 760                 765             


Cys Cys Ala Glu Glu Asp Lys Lys Thr Glu Ile Leu Asp Pro Asp Thr 
    770                 775                 780                 


Leu Glu Asn Gln Ala Thr Val Glu Phe His Ser Gly Asp Lys Thr Met 
785                 790                 795                 800 


Glu Cys Glu Lys Leu Gly Leu Ser Lys His Thr Thr Asn Asp Arg Thr 
                805                 810                 815     


Lys Tyr Ile Asp Asp Thr Val Lys His Lys Val Lys Ile Leu Lys Arg 
            820                 825                 830         


Glu Ser Gly Glu Gly Arg Asn Ser Ser Asp Cys Arg Asp Asn Glu Ile 
        835                 840                 845             


Lys Lys Trp Gln Leu Ala Pro Leu Arg Lys Met Gly Gln Pro Val Leu 
    850                 855                 860                 


Pro Arg Arg Ser Ser Glu Glu Lys Ser Glu Lys Ile Pro Lys Glu Ser 
865                 870                 875                 880 


Thr Thr Val Thr Cys Thr Gly Glu Lys Ala Ser Lys Pro Gly Thr His 
                885                 890                 895     


Glu Lys Gln Glu Met Lys Lys Lys Lys Val Glu Lys Gly Val Leu Asn 
            900                 905                 910         


Val His Pro Ala Ala Ser Ala Ser Lys Pro Ser Ala Asp Gln Ile Arg 
        915                 920                 925             


Gln Ser Val Arg His Ser Leu Lys Asp Ile Leu Met Lys Arg Leu Thr 
    930                 935                 940                 


Asp Ser Asn Leu Lys Val Pro Glu Glu Lys Ala Ala Lys Val Ala Thr 
945                 950                 955                 960 


Lys Ile Glu Lys Glu Leu Phe Ser Phe Phe Arg Asp Thr Asp Ala Lys 
                965                 970                 975     


Tyr Lys Asn Lys Tyr Arg Ser Leu Met Phe Asn Leu Lys Asp Pro Lys 
            980                 985                 990         


Asn Asn Ile Leu Phe Lys Lys Val  Leu Lys Gly Glu Val  Thr Pro Asp 
        995                 1000                 1005             


His Leu  Ile Arg Met Ser Pro  Glu Glu Leu Ala Ser  Lys Glu Leu 
    1010                 1015                 1020             


Ala Ala  Trp Arg Arg Arg Glu  Asn Arg His Thr Ile  Glu Met Ile 
    1025                 1030                 1035             


Glu Lys  Glu Gln Arg Glu Val  Glu Arg Arg Pro Ile  Thr Lys Ile 
    1040                 1045                 1050             


Thr His  Lys Gly Glu Ile Glu  Ile Glu Ser Asp Ala  Pro Met Lys 
    1055                 1060                 1065             


Glu Gln  Glu Ala Ala Met Glu  Ile Gln Glu Pro Ala  Ala Asn Lys 
    1070                 1075                 1080             


Ser Leu  Glu Lys Pro Glu Gly  Ser Glu Lys Gln Lys  Glu Glu Val 
    1085                 1090                 1095             


Asp Ser  Met Ser Lys Asp Thr  Thr Ser Gln His Arg  Gln His Leu 
    1100                 1105                 1110             


Phe Asp  Leu Asn Cys Lys Ile  Cys Ile Gly Arg Met  Ala Pro Pro 
    1115                 1120                 1125             


Val Asp  Asp Leu Ser Pro Lys  Lys Val Lys Val Val  Val Gly Val 
    1130                 1135                 1140             


Ala Arg  Lys His Ser Asp Asn  Glu Ala Glu Ser Ile  Ala Asp Ala 
    1145                 1150                 1155             


Leu Ser  Ser Thr Ser Asn Ile  Leu Ala Ser Glu Phe  Phe Glu Glu 
    1160                 1165                 1170             


Glu Lys  Gln Glu Ser Pro Lys  Ser Thr Phe Ser Pro  Ala Pro Arg 
    1175                 1180                 1185             


Pro Glu  Met Pro Gly Thr Val  Glu Val Glu Ser Thr  Phe Leu Ala 
    1190                 1195                 1200             


Arg Leu  Asn Phe Ile Trp Lys  Gly Phe Ile Asn Met  Pro Ser Val 
    1205                 1210                 1215             


Ala Lys  Phe Val Thr Lys Ala  Tyr Pro Val Ser Gly  Ser Pro Glu 
    1220                 1225                 1230             


Tyr Leu  Thr Glu Asp Leu Pro  Asp Ser Ile Gln Val  Gly Gly Arg 
    1235                 1240                 1245             


Ile Ser  Pro Gln Thr Val Trp  Asp Tyr Val Glu Lys  Ile Lys Ala 
    1250                 1255                 1260             


Ser Gly  Thr Lys Glu Ile Cys  Val Val Arg Phe Thr  Pro Val Thr 
    1265                 1270                 1275             


Glu Glu  Asp Gln Ile Ser Tyr  Thr Leu Leu Phe Ala  Tyr Phe Ser 
    1280                 1285                 1290             


Ser Arg  Lys Arg Tyr Gly Val  Ala Ala Asn Asn Met  Lys Gln Val 
    1295                 1300                 1305             


Lys Asp  Met Tyr Leu Ile Pro  Leu Gly Ala Thr Asp  Lys Ile Pro 
    1310                 1315                 1320             


His Pro  Leu Val Pro Phe Asp  Gly Pro Gly Leu Glu  Leu His Arg 
    1325                 1330                 1335             


Pro Asn  Leu Leu Leu Gly Leu  Ile Ile Arg Gln Lys  Leu Lys Arg 
    1340                 1345                 1350             


Gln His  Ser Ala Cys Ala Ser  Thr Ser His Ile Ala  Glu Thr Pro 
    1355                 1360                 1365             


Glu Ser  Ala Pro Pro Ile Ala  Leu Pro Pro Asp Lys  Lys Ser Lys 
    1370                 1375                 1380             


Ile Glu  Val Ser Thr Glu Glu  Ala Pro Glu Glu Glu  Asn Asp Phe 
    1385                 1390                 1395             


Phe Asn  Ser Phe Thr Thr Val  Leu His Lys Gln Arg  Asn Lys Pro 
    1400                 1405                 1410             


Gln Gln  Asn Leu Gln Glu Asp  Leu Pro Thr Ala Val  Glu Pro Leu 
    1415                 1420                 1425             


Met Glu  Val Thr Lys Gln Glu  Pro Pro Lys Pro Leu  Arg Phe Leu 
    1430                 1435                 1440             


Pro Gly  Val Leu Ile Gly Trp  Glu Asn Gln Pro Thr  Thr Leu Glu 
    1445                 1450                 1455             


Leu Ala  Asn Lys Pro Leu Pro  Val Asp Asp Ile Leu  Gln Ser Leu 
    1460                 1465                 1470             


Leu Gly  Thr Thr Gly Gln Val  Tyr Asp Gln Ala Gln  Ser Val Met 
    1475                 1480                 1485             


Glu Gln  Asn Thr Val Lys Glu  Ile Pro Phe Leu Asn  Glu Gln Thr 
    1490                 1495                 1500             


Asn Ser  Lys Ile Glu Lys Thr  Asp Asn Val Glu Val  Thr Asp Gly 
    1505                 1510                 1515             


Glu Asn  Lys Glu Ile Lys Val  Lys Val Asp Asn Ile  Ser Glu Ser 
    1520                 1525                 1530             


Thr Asp  Lys Ser Ala Glu Ile  Glu Thr Ser Val Val  Gly Ser Ser 
    1535                 1540                 1545             


Ser Ile  Ser Ala Gly Ser Leu  Thr Ser Leu Ser Leu  Arg Gly Lys 
    1550                 1555                 1560             


Pro Pro  Asp Val Ser Thr Glu  Ala Phe Leu Thr Asn  Leu Ser Ile 
    1565                 1570                 1575             


Gln Ser  Lys Gln Glu Glu Thr  Val Glu Ser Lys Glu  Lys Thr Leu 
    1580                 1585                 1590             


Lys Arg  Gln Leu Gln Glu Asp  Gln Glu Asn Asn Leu  Gln Asp Asn 
    1595                 1600                 1605             


Gln Thr  Ser Asn Ser Ser Pro  Cys Arg Ser Asn Val  Gly Lys Gly 
    1610                 1615                 1620             


Asn Ile  Asp Gly Asn Val Ser  Cys Ser Glu Asn Leu  Val Ala Asn 
    1625                 1630                 1635             


Thr Ala  Arg Ser Pro Gln Phe  Ile Asn Leu Lys Arg  Asp Pro Arg 
    1640                 1645                 1650             


Gln Ala  Ala Gly Arg Ser Gln  Pro Val Thr Thr Ser  Glu Ser Lys 
    1655                 1660                 1665             


Asp Gly  Asp Ser Cys Arg Asn  Gly Glu Lys His Met  Leu Pro Gly 
    1670                 1675                 1680             


Leu Ser  His Asn Lys Glu His  Leu Thr Glu Gln Ile  Asn Val Glu 
    1685                 1690                 1695             


Glu Lys  Leu Cys Ser Ala Glu  Lys Asn Ser Cys Val  Gln Gln Ser 
    1700                 1705                 1710             


Asp Asn  Leu Lys Val Ala Gln  Asn Ser Pro Ser Val  Glu Asn Ile 
    1715                 1720                 1725             


Gln Thr  Ser Gln Ala Glu Gln  Ala Lys Pro Leu Gln  Glu Asp Ile 
    1730                 1735                 1740             


Leu Met  Gln Asn Ile Glu Thr  Val His Pro Phe Arg  Arg Gly Ser 
    1745                 1750                 1755             


Ala Val  Ala Thr Ser His Phe  Glu Val Gly Asn Thr  Cys Pro Ser 
    1760                 1765                 1770             


Glu Phe  Pro Ser Lys Ser Ile  Thr Phe Thr Ser Arg  Ser Thr Ser 
    1775                 1780                 1785             


Pro Arg  Thr Ser Thr Asn Phe  Ser Pro Met Arg Pro  Gln Gln Pro 
    1790                 1795                 1800             


Asn Leu  Gln His Leu Lys Ser  Ser Pro Pro Gly Phe  Pro Phe Pro 
    1805                 1810                 1815             


Gly Pro  Pro Asn Phe Pro Pro  Gln Ser Met Phe Gly  Phe Pro Pro 
    1820                 1825                 1830             


His Leu  Pro Pro Pro Leu Leu  Pro Pro Pro Gly Phe  Gly Phe Ala 
    1835                 1840                 1845             


Gln Asn  Pro Met Val Pro Trp  Pro Pro Val Val His  Leu Pro Gly 
    1850                 1855                 1860             


Gln Pro  Gln Arg Met Met Gly  Pro Leu Ser Gln Ala  Ser Arg Tyr 
    1865                 1870                 1875             


Ile Gly  Pro Gln Asn Phe Tyr  Gln Val Lys Asp Ile  Arg Arg Pro 
    1880                 1885                 1890             


Glu Arg  Arg His Ser Asp Pro  Trp Gly Arg Gln Asp  Gln Gln Gln 
    1895                 1900                 1905             


Leu Asp  Arg Pro Phe Asn Arg  Gly Lys Gly Asp Arg  Gln Arg Phe 
    1910                 1915                 1920             


Tyr Ser  Asp Ser His His Leu  Lys Arg Glu Arg His  Glu Lys Glu 
    1925                 1930                 1935             


Trp Glu  Gln Glu Ser Glu Arg  His Arg Arg Arg Asp  Arg Ser Gln 
    1940                 1945                 1950             


Asp Lys  Asp Arg Asp Arg Lys  Ser Arg Glu Glu Gly  His Lys Asp 
    1955                 1960                 1965             


Lys Glu  Arg Ala Arg Leu Ser  His Gly Asp Arg Gly  Thr Asp Gly 
    1970                 1975                 1980             


Lys Ala  Ser Arg Asp Ser Arg  Asn Val Asp Lys Lys  Pro Asp Lys 
    1985                 1990                 1995             


Pro Lys  Ser Glu Asp Tyr Glu  Lys Asp Lys Glu Arg  Glu Lys Ser 
    2000                 2005                 2010             


Lys His  Arg Glu Gly Glu Lys  Asp Arg Asp Arg Tyr  His Lys Asp 
    2015                 2020                 2025             


Arg Asp  His Thr Asp Arg Thr  Lys Ser Lys Arg 
    2030                 2035                 


<210>  295
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Gln Ala Gln Ala Pro Val Val Val Val Thr Gln Pro Gly Val Gly 
1               5                   10                  15      


Pro Gly Pro Ala Pro Gln Asn Ser Asn Trp Gln Thr Gly Met Cys Asp 
            20                  25                  30          


Cys Phe Ser Asp Cys Gly Val Cys Leu Cys Gly Thr Phe Cys Phe Pro 
        35                  40                  45              


Cys Leu Gly Cys Gln Val Ala Ala Asp Met Asn Glu Cys Cys Leu Cys 
    50                  55                  60                  


Gly Thr Ser Val Ala Met Arg Thr Leu Tyr Arg Thr Arg Tyr Gly Ile 
65                  70                  75                  80  


Pro Gly Ser Ile Cys Asp Asp Tyr Met Ala Thr Leu Cys Cys Pro His 
                85                  90                  95      


Cys Thr Leu Cys Gln Ile Lys Arg Asp Ile Asn Arg Arg Arg Ala Met 
            100                 105                 110         


Arg Thr Phe 
        115 


<210>  296
<211>  1163
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Pro Val Ser Thr Ser Leu His Gln Asp Gly Ser Gln Glu Arg Pro 
1               5                   10                  15      


Val Ser Leu Thr Ser Thr Thr Ser Ser Ser Gly Ser Ser Cys Asp Ser 
            20                  25                  30          


Arg Ser Ala Met Glu Glu Pro Ser Ser Ser Glu Ala Pro Ala Lys Asn 
        35                  40                  45              


Gly Ala Gly Ser Leu Arg Ser Arg His Leu Pro Asn Ser Asn Asn Asn 
    50                  55                  60                  


Ser Ser Ser Trp Leu Asn Val Lys Gly Pro Leu Ser Pro Phe Asn Ser 
65                  70                  75                  80  


Arg Ala Ala Ala Gly Pro Ala His His Lys Leu Ser Tyr Leu Gly Arg 
                85                  90                  95      


Val Val Arg Glu Ile Val Glu Thr Glu Arg Met Tyr Val Gln Asp Leu 
            100                 105                 110         


Arg Ser Ile Val Glu Ser Gln Glu Phe Asp Ile Tyr Thr Gln Tyr Cys 
        115                 120                 125             


Asn Asn Tyr Pro Asn Ser Val Ala Ala Leu Thr Glu Cys Met Arg Asp 
    130                 135                 140                 


Lys Gln Gln Ala Lys Phe Phe Arg Asp Arg Gln Glu Leu Leu Gln His 
145                 150                 155                 160 


Ser Leu Pro Leu Gly Ser Tyr Leu Leu Lys Pro Val Gln Arg Ile Leu 
                165                 170                 175     


Lys Tyr His Leu Leu Leu Gln Glu Ile Ala Lys His Phe Asp Glu Glu 
            180                 185                 190         


Glu Asp Gly Phe Glu Val Val Glu Asp Ala Ile Asp Thr Met Thr Cys 
        195                 200                 205             


Val Ala Trp Tyr Ile Asn Asp Met Lys Arg Arg His Glu His Ala Val 
    210                 215                 220                 


Arg Leu Gln Glu Ile Gln Ser Leu Leu Ile Asn Trp Lys Gly Pro Asp 
225                 230                 235                 240 


Leu Thr Thr Tyr Gly Glu Leu Val Leu Glu Gly Thr Phe Arg Val His 
                245                 250                 255     


Arg Val Arg Asn Glu Arg Thr Phe Phe Leu Phe Asp Lys Thr Leu Leu 
            260                 265                 270         


Ile Thr Lys Lys Arg Gly Asp His Phe Val Tyr Lys Gly Asn Ile Pro 
        275                 280                 285             


Cys Ser Ser Leu Met Leu Ile Glu Ser Thr Arg Asp Ser Leu Cys Phe 
    290                 295                 300                 


Thr Val Thr His Tyr Lys His Ser Lys Gln Gln Tyr Ser Ile Gln Ala 
305                 310                 315                 320 


Lys Thr Val Glu Glu Lys Arg Asn Trp Thr His His Ile Lys Arg Leu 
                325                 330                 335     


Ile Leu Glu Asn His His Ala Thr Ile Pro Gln Lys Ala Lys Glu Ala 
            340                 345                 350         


Ile Leu Glu Met Asp Ser Tyr Tyr Pro Asn Arg Tyr Arg Cys Ser Pro 
        355                 360                 365             


Glu Arg Leu Lys Lys Ala Trp Ser Ser Gln Asp Glu Val Ser Thr Asn 
    370                 375                 380                 


Val Arg Gln Gly Arg Arg Gln Ser Glu Pro Thr Lys His Leu Leu Arg 
385                 390                 395                 400 


Gln Leu Asn Glu Lys Ala Arg Ala Ala Gly Met Lys Gly Lys Gly Arg 
                405                 410                 415     


Arg Glu Ser Glu Ser Ser Arg Ser Ser Arg Arg Pro Ser Gly Arg Ser 
            420                 425                 430         


Pro Thr Ser Thr Glu Lys Arg Met Ser Phe Glu Ser Ile Ser Ser Leu 
        435                 440                 445             


Pro Glu Val Glu Pro Asp Pro Glu Ala Gly Ser Glu Gln Glu Val Phe 
    450                 455                 460                 


Ser Ala Val Glu Gly Pro Ser Ala Glu Glu Thr Pro Ser Asp Thr Glu 
465                 470                 475                 480 


Ser Pro Glu Val Leu Glu Thr Gln Leu Asp Ala His Gln Gly Leu Leu 
                485                 490                 495     


Gly Met Asp Pro Pro Gly Asp Met Val Asp Phe Val Ala Ala Glu Ser 
            500                 505                 510         


Thr Glu Asp Leu Lys Ala Leu Ser Ser Glu Glu Glu Glu Glu Met Gly 
        515                 520                 525             


Gly Ala Ala Gln Glu Pro Glu Ser Leu Leu Pro Pro Ser Val Leu Asp 
    530                 535                 540                 


Gln Ala Ser Val Ile Ala Glu Arg Phe Val Ser Ser Phe Ser Arg Arg 
545                 550                 555                 560 


Ser Ser Val Ala Gln Glu Asp Ser Lys Ser Ser Gly Phe Gly Ser Pro 
                565                 570                 575     


Arg Leu Val Ser Arg Ser Ser Ser Val Leu Ser Leu Glu Gly Ser Glu 
            580                 585                 590         


Lys Gly Leu Ala Arg His Gly Ser Ala Thr Asp Ser Leu Ser Cys Gln 
        595                 600                 605             


Leu Ser Pro Glu Val Asp Ile Ser Val Gly Val Ala Thr Glu Asp Ser 
    610                 615                 620                 


Pro Ser Val Asn Gly Met Glu Pro Pro Ser Pro Gly Cys Pro Val Glu 
625                 630                 635                 640 


Pro Asp Arg Ser Ser Cys Lys Lys Lys Glu Ser Ala Leu Ser Thr Arg 
                645                 650                 655     


Asp Arg Leu Leu Leu Asp Lys Ile Lys Ser Tyr Tyr Glu Asn Ala Glu 
            660                 665                 670         


His His Asp Ala Gly Phe Ser Val Arg Arg Arg Glu Ser Leu Ser Tyr 
        675                 680                 685             


Ile Pro Lys Gly Leu Val Arg Asn Ser Ile Ser Arg Phe Asn Ser Leu 
    690                 695                 700                 


Pro Arg Pro Asp Pro Glu Pro Val Pro Pro Val Gly Ser Lys Arg Gln 
705                 710                 715                 720 


Val Gly Ser Arg Pro Thr Ser Trp Ala Leu Phe Glu Leu Pro Gly Pro 
                725                 730                 735     


Ser Gln Ala Val Lys Gly Asp Pro Pro Pro Ile Ser Asp Ala Glu Phe 
            740                 745                 750         


Arg Pro Ser Ser Glu Ile Val Lys Ile Trp Glu Gly Met Glu Ser Ser 
        755                 760                 765             


Gly Gly Ser Pro Gly Lys Gly Pro Gly Gln Gly Gln Ala Asn Gly Phe 
    770                 775                 780                 


Asp Leu His Glu Pro Leu Phe Ile Leu Glu Glu His Glu Leu Gly Ala 
785                 790                 795                 800 


Ile Thr Glu Glu Ser Ala Thr Ala Ser Pro Glu Ser Ser Ser Pro Thr 
                805                 810                 815     


Glu Gly Arg Ser Pro Ala His Leu Ala Arg Glu Leu Lys Glu Leu Val 
            820                 825                 830         


Lys Glu Leu Ser Ser Ser Thr Gln Gly Glu Leu Val Ala Pro Leu His 
        835                 840                 845             


Pro Arg Ile Val Gln Leu Ser His Val Met Asp Ser His Val Ser Glu 
    850                 855                 860                 


Arg Val Lys Asn Lys Val Tyr Gln Leu Ala Arg Gln Tyr Ser Leu Arg 
865                 870                 875                 880 


Ile Lys Ser Asn Lys Pro Val Met Ala Arg Pro Pro Leu Gln Trp Glu 
                885                 890                 895     


Lys Val Ala Pro Glu Arg Asp Gly Lys Ser Pro Thr Val Pro Cys Leu 
            900                 905                 910         


Gln Glu Glu Ala Gly Glu Pro Leu Gly Gly Lys Gly Lys Arg Lys Pro 
        915                 920                 925             


Val Leu Ser Leu Phe Asp Tyr Glu Gln Leu Met Ala Gln Glu His Ser 
    930                 935                 940                 


Pro Pro Lys Pro Ser Ser Ala Gly Glu Met Ser Pro Gln Arg Phe Phe 
945                 950                 955                 960 


Phe Asn Pro Ser Ala Val Ser Gln Arg Thr Thr Ser Pro Gly Gly Arg 
                965                 970                 975     


Pro Ser Ala Arg Ser Pro Leu Ser Pro Thr Glu Thr Phe Ser Trp Pro 
            980                 985                 990         


Asp Val Arg Glu Leu Cys Ser Lys  Tyr Ala Ser Arg Asp  Glu Ala Arg 
        995                 1000                 1005             


Arg Ala  Gly Gly Gly Arg Pro  Arg Gly Pro Pro Val  Asn Arg Ser 
    1010                 1015                 1020             


His Ser  Val Pro Glu Asn Met  Val Glu Pro Pro Leu  Ser Gly Arg 
    1025                 1030                 1035             


Val Gly  Arg Cys Arg Ser Leu  Ser Thr Lys Arg Gly  Arg Gly Gly 
    1040                 1045                 1050             


Gly Glu  Ala Ala Gln Ser Pro  Gly Pro Leu Pro Gln  Ser Lys Pro 
    1055                 1060                 1065             


Asp Gly  Gly Glu Thr Leu Tyr  Val Thr Ala Asp Leu  Thr Leu Glu 
    1070                 1075                 1080             


Asp Asn  Arg Arg Val Ile Val  Met Glu Lys Gly Pro  Leu Pro Ser 
    1085                 1090                 1095             


Pro Thr  Ala Gly Leu Glu Glu  Ser Ser Gly Gln Gly  Pro Ser Ser 
    1100                 1105                 1110             


Pro Val  Ala Leu Leu Gly Gln  Val Gln Asp Phe Gln  Gln Ser Ala 
    1115                 1120                 1125             


Glu Cys  Gln Pro Lys Glu Glu  Gly Ser Arg Asp Pro  Ala Asp Pro 
    1130                 1135                 1140             


Ser Gln  Gln Gly Arg Val Arg  Asn Leu Arg Glu Lys  Phe Gln Ala 
    1145                 1150                 1155             


Leu Asn  Ser Val Gly 
    1160             


<210>  297
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Glu Pro Gly Glu Val Lys Asp Arg Ile Leu Glu Asn Ile Ser Leu 
1               5                   10                  15      


Ser Val Lys Lys Leu Gln Ser Tyr Phe Ala Ala Cys Glu Asp Glu Ile 
            20                  25                  30          


Pro Ala Ile Arg Asn His Asp Lys Val Leu Gln Arg Leu Cys Glu His 
        35                  40                  45              


Leu Asp His Ala Leu Leu Tyr Gly Leu Gln Asp Leu Ser Ser Gly Tyr 
    50                  55                  60                  


Trp Val Leu Val Val His Phe Thr Arg Arg Glu Ala Ile Lys Gln Ile 
65                  70                  75                  80  


Glu Val Leu Gln His Val Ala Thr Asn Leu Gly Arg Ser Arg Ala Trp 
                85                  90                  95      


Leu Tyr Leu Ala Leu Asn Glu Asn Ser Leu Glu Ser Tyr Leu Arg Leu 
            100                 105                 110         


Phe Gln Glu Asn Leu Gly Leu Leu His Lys Tyr Tyr Val Lys Asn Ala 
        115                 120                 125             


Leu Val Cys Ser His Asp His Leu Thr Leu Phe Leu Thr Leu Val Ser 
    130                 135                 140                 


Gly Leu Glu Phe Ile Arg Phe Glu Leu Asp Leu Asp Ala Pro Tyr Leu 
145                 150                 155                 160 


Asp Leu Ala Pro Tyr Met Pro Asp Tyr Tyr Lys Pro Gln Tyr Leu Leu 
                165                 170                 175     


Asp Phe Glu Asp Arg Leu Pro Ser Ser Val His Gly Ser Asp Ser Leu 
            180                 185                 190         


Ser Leu Asn Ser Phe Asn Ser Val Thr Ser Thr Asn Leu Glu Trp Asp 
        195                 200                 205             


Asp Ser Ala Ile Ala Pro Ser Ser Glu Asp Tyr Asp Phe Gly Asp Val 
    210                 215                 220                 


Phe Pro Ala Val Pro Ser Val Pro Ser Thr Asp Trp Glu Asp Gly Asp 
225                 230                 235                 240 


Leu Thr Asp Thr Val Ser Gly Pro Arg Ser Thr Ala Ser Asp Leu Thr 
                245                 250                 255     


Ser Ser Lys Ala Ser Thr Arg Ser Pro Thr Gln Arg Gln Asn Pro Phe 
            260                 265                 270         


Asn Glu Glu Pro Ala Glu Thr Val Ser Ser Ser Asp Thr Thr Pro Val 
        275                 280                 285             


His Thr Thr Ser Gln Glu Lys Glu Glu Ala Gln Ala Leu Asp Pro Pro 
    290                 295                 300                 


Asp Ala Cys Thr Glu Leu Glu Val Ile Arg Val Thr Lys Lys Lys Lys 
305                 310                 315                 320 


Ile Gly Lys Lys Lys Lys Ser Arg Ser Asp Glu Glu Ala Ser Pro Leu 
                325                 330                 335     


His Pro Ala Cys Ser Gln Lys Lys Cys Ala Lys Gln Gly Asp Gly Asp 
            340                 345                 350         


Ser Arg Asn Gly Ser Pro Ser Leu Gly Arg Asp Ser Pro Asp Thr Met 
        355                 360                 365             


Leu Ala Ser Pro Gln Glu Glu Gly Glu Gly Pro Ser Ser Thr Thr Glu 
    370                 375                 380                 


Ser Ser Glu Arg Ser Glu Pro Gly Leu Leu Ile Pro Glu Met Lys Asp 
385                 390                 395                 400 


Thr Ser Met Glu Arg Leu Gly Gln Pro Leu Ser Lys Val Ile Asp Gln 
                405                 410                 415     


Leu Asn Gly Gln Leu Asp Pro Ser Thr Trp Cys Ser Arg Ala Glu Pro 
            420                 425                 430         


Pro Asp Gln Ser Phe Arg Thr Gly Ser Pro Gly Asp Ala Pro Glu Arg 
        435                 440                 445             


Pro Pro Leu Cys Asp Phe Ser Glu Gly Leu Ser Ala Pro Met Asp Phe 
    450                 455                 460                 


Tyr Arg Phe Thr Val Glu Ser Pro Ser Thr Val Thr Ser Gly Gly Gly 
465                 470                 475                 480 


His His Asp Pro Ala Gly Leu Gly Gln Pro Leu His Val Pro Ser Ser 
                485                 490                 495     


Pro Glu Ala Ala Gly Gln Glu Glu Glu Gly Gly Gly Gly Glu Gly Gln 
            500                 505                 510         


Thr Pro Arg Pro Leu Glu Asp Thr Thr Arg Glu Ala Gln Glu Leu Glu 
        515                 520                 525             


Ala Gln Leu Ser Leu Val Arg Glu Gly Pro Val Ser Glu Pro Glu Pro 
    530                 535                 540                 


Gly Thr Gln Glu Val Leu Cys Gln Leu Lys Arg Asp Gln Pro Ser Pro 
545                 550                 555                 560 


Cys Leu Ser Ser Ala Glu Asp Ser Gly Val Asp Glu Gly Gln Gly Ser 
                565                 570                 575     


Pro Ser Glu Met Val His Ser Ser Glu Phe Arg Val Asp Asn Asn His 
            580                 585                 590         


Leu Leu Leu Leu Met Ile His Val Phe Arg Glu Asn Glu Glu Gln Leu 
        595                 600                 605             


Phe Lys Met Ile Arg Met Ser Thr Gly His Met Glu Gly Asn Leu Gln 
    610                 615                 620                 


Leu Leu Tyr Val Leu Leu Thr Asp Cys Tyr Val Tyr Leu Leu Arg Lys 
625                 630                 635                 640 


Gly Ala Thr Glu Lys Pro Tyr Leu Val Glu Glu Ala Val Ser Tyr Asn 
                645                 650                 655     


Glu Leu Asp Tyr Val Ser Val Gly Leu Asp Gln Gln Thr Val Lys Leu 
            660                 665                 670         


Val Cys Thr Asn Arg Arg Lys Gln Phe Leu Leu Asp Thr Ala Asp Val 
        675                 680                 685             


Ala Leu Ala Glu Phe Phe Leu Ala Ser Leu Lys Ser Ala Met Ile Lys 
    690                 695                 700                 


Gly Cys Arg Glu Pro Pro Tyr Pro Ser Ile Leu Thr Asp Ala Thr Met 
705                 710                 715                 720 


Glu Lys Leu Ala Leu Ala Lys Phe Val Ala Gln Glu Ser Lys Cys Glu 
                725                 730                 735     


Ala Ser Ala Val Thr Val Arg Phe Tyr Gly Leu Val His Trp Glu Asp 
            740                 745                 750         


Pro Thr Asp Glu Ser Leu Gly Pro Thr Pro Cys His Cys Ser Pro Pro 
        755                 760                 765             


Glu Gly Thr Ile Thr Lys Glu Gly Met Leu His Tyr Lys Ala Gly Thr 
    770                 775                 780                 


Ser Tyr Leu Gly Lys Glu His Trp Lys Thr Cys Phe Val Val Leu Ser 
785                 790                 795                 800 


Asn Gly Ile Leu Tyr Gln Tyr Pro Asp Arg Thr Asp Val Ile Pro Leu 
                805                 810                 815     


Leu Ser Val Asn Met Gly Gly Glu Gln Cys Gly Gly Cys Arg Arg Ala 
            820                 825                 830         


Asn Thr Thr Asp Arg Pro His Ala Phe Gln Val Ile Leu Ser Asp Arg 
        835                 840                 845             


Pro Cys Leu Glu Leu Ser Ala Glu Ser Glu Ala Glu Met Ala Glu Trp 
    850                 855                 860                 


Met Gln His Leu Cys Gln Ala Val Ser Lys Gly Val Ile Pro Gln Gly 
865                 870                 875                 880 


Val Ala Pro Ser Pro Cys Ile Pro Cys Cys Leu Val Leu Thr Asp Asp 
                885                 890                 895     


Arg Leu Phe Thr Cys His Glu Asp Cys Gln Thr Ser Phe Phe Arg Ser 
            900                 905                 910         


Leu Gly Thr Ala Lys Leu Gly Asp Ile Ser Ala Val Ser Thr Glu Pro 
        915                 920                 925             


Gly Lys Glu Tyr Cys Val Leu Glu Phe Ser Gln Asp Ser Gln Gln Leu 
    930                 935                 940                 


Leu Pro Pro Trp Val Ile Tyr Leu Ser Cys Thr Ser Glu Leu Asp Arg 
945                 950                 955                 960 


Leu Leu Ser Ala Leu Asn Ser Gly Trp Lys Thr Ile Tyr Gln Val Asp 
                965                 970                 975     


Leu Pro His Thr Ala Ile Gln Glu Ala Ser Asn Lys Lys Lys Phe Glu 
            980                 985                 990         


Asp Ala Leu Ser Leu Ile His Ser  Ala Trp Gln Arg Ser  Asp Ser Leu 
        995                 1000                 1005             


Cys Arg  Gly Arg Ala Ser Arg  Asp Pro Trp Cys 
    1010                 1015                 


<210>  298
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Pro Tyr Ala Asn Gln Pro Thr Val Arg Ile Thr Glu Leu Thr Asp 
1               5                   10                  15      


Glu Asn Val Lys Phe Ile Ile Glu Asn Thr Asp Leu Ala Val Ala Asn 
            20                  25                  30          


Ser Ile Arg Arg Val Phe Ile Ala Glu Val Pro Ile Ile Ala Ile Asp 
        35                  40                  45              


Trp Val Gln Ile Asp Ala Asn Ser Ser Val Leu His Asp Glu Phe Ile 
    50                  55                  60                  


Ala His Arg Leu Gly Leu Ile Pro Leu Ile Ser Asp Asp Ile Val Asp 
65                  70                  75                  80  


Lys Leu Gln Tyr Ser Arg Asp Cys Thr Cys Glu Glu Phe Cys Pro Glu 
                85                  90                  95      


Cys Ser Val Glu Phe Thr Leu Asp Val Arg Cys Asn Glu Asp Gln Thr 
            100                 105                 110         


Arg His Val Thr Ser Arg Asp Leu Ile Ser Asn Ser Pro Arg Val Ile 
        115                 120                 125             


Pro Val Thr Ser Arg Asn Arg Asp Asn Asp Pro Asn Asp Tyr Val Glu 
    130                 135                 140                 


Gln Asp Asp Ile Leu Ile Val Lys Leu Arg Lys Gly Gln Glu Leu Arg 
145                 150                 155                 160 


Leu Arg Ala Tyr Ala Lys Lys Gly Phe Gly Lys Glu His Ala Lys Trp 
                165                 170                 175     


Asn Pro Thr Ala Gly Val Ala Phe Glu Tyr Asp Pro Asp Asn Ala Leu 
            180                 185                 190         


Arg His Thr Val Tyr Pro Lys Pro Glu Glu Trp Pro Lys Ser Glu Tyr 
        195                 200                 205             


Ser Glu Leu Asp Glu Asp Glu Ser Gln Ala Pro Tyr Asp Pro Asn Gly 
    210                 215                 220                 


Lys Pro Glu Arg Phe Tyr Tyr Asn Val Glu Ser Cys Gly Ser Leu Arg 
225                 230                 235                 240 


Pro Glu Thr Ile Val Leu Ser Ala Leu Ser Gly Leu Lys Lys Lys Leu 
                245                 250                 255     


Ser Asp Leu Gln Thr Gln Leu Ser His Glu Ile Gln Ser Asp Val Leu 
            260                 265                 270         


Thr Ile Asn 
        275 


<210>  299
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                245                 250                 255     


Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
            260                 265                 270         


Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
        275                 280                 285             


Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 
    290                 295                 300                 


Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr 
305                 310                 315                 320 


Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 330 


<210>  300
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  301
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Ala Glu Ala Gly Ala Gly Leu Ser Glu Thr Val Thr Glu Thr Thr 
1               5                   10                  15      


Val Thr Val Thr Thr Glu Pro Glu Asn Arg Ser Leu Thr Ile Lys Leu 
            20                  25                  30          


Arg Lys Arg Lys Pro Glu Lys Lys Val Glu Trp Thr Ser Asp Thr Val 
        35                  40                  45              


Asp Asn Glu His Met Gly Arg Arg Ser Ser Lys Cys Cys Cys Ile Tyr 
    50                  55                  60                  


Glu Lys Pro Arg Ala Phe Gly Glu Ser Ser Thr Glu Ser Asp Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Gly Cys Gly His Thr His Cys Val Arg Gly His Arg Lys 
                85                  90                  95      


Gly Arg Arg Arg Ala Thr Leu Gly Pro Thr Pro Thr Thr Pro Pro Gln 
            100                 105                 110         


Pro Pro Asp Pro Ser Gln Pro Pro Pro Gly Pro Met Gln His 
        115                 120                 125     


<210>  302
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Arg Val Leu Gly Gly Arg Cys Gly Ala Leu Leu Ala Cys Leu Leu 
1               5                   10                  15      


Leu Val Leu Pro Val Ser Glu Ala Asn Phe Leu Ser Lys Gln Gln Ala 
            20                  25                  30          


Ser Gln Val Leu Val Arg Lys Arg Arg Ala Asn Ser Leu Leu Glu Glu 
        35                  40                  45              


Thr Lys Gln Gly Asn Leu Glu Arg Glu Cys Ile Glu Glu Leu Cys Asn 
    50                  55                  60                  


Lys Glu Glu Ala Arg Glu Val Phe Glu Asn Asp Pro Glu Thr Asp Tyr 
65                  70                  75                  80  


Phe Tyr Pro Lys Tyr Leu Val Cys Leu Arg Ser Phe Gln Thr Gly Leu 
                85                  90                  95      


Phe Thr Ala Ala Arg Gln Ser Thr Asn Ala Tyr Pro Asp Leu Arg Ser 
            100                 105                 110         


Cys Val Asn Ala Ile Pro Asp Gln Cys Ser Pro Leu Pro Cys Asn Glu 
        115                 120                 125             


Asp Gly Tyr Met Ser Cys Lys Asp Gly Lys Ala Ser Phe Thr Cys Thr 
    130                 135                 140                 


Cys Lys Pro Gly Trp Gln Gly Glu Lys Cys Glu Phe Asp Ile Asn Glu 
145                 150                 155                 160 


Cys Lys Asp Pro Ser Asn Ile Asn Gly Gly Cys Ser Gln Ile Cys Asp 
                165                 170                 175     


Asn Thr Pro Gly Ser Tyr His Cys Ser Cys Lys Asn Gly Phe Val Met 
            180                 185                 190         


Leu Ser Asn Lys Lys Asp Cys Lys Asp Val Asp Glu Cys Ser Leu Lys 
        195                 200                 205             


Pro Ser Ile Cys Gly Thr Ala Val Cys Lys Asn Ile Pro Gly Asp Phe 
    210                 215                 220                 


Glu Cys Glu Cys Pro Glu Gly Tyr Arg Tyr Asn Leu Lys Ser Lys Ser 
225                 230                 235                 240 


Cys Glu Asp Ile Asp Glu Cys Ser Glu Asn Met Cys Ala Gln Leu Cys 
                245                 250                 255     


Val Asn Tyr Pro Gly Gly Tyr Thr Cys Tyr Cys Asp Gly Lys Lys Gly 
            260                 265                 270         


Phe Lys Leu Ala Gln Asp Gln Lys Ser Cys Glu Val Val Ser Val Cys 
        275                 280                 285             


Leu Pro Leu Asn Leu Asp Thr Lys Tyr Glu Leu Leu Tyr Leu Ala Glu 
    290                 295                 300                 


Gln Phe Ala Gly Val Val Leu Tyr Leu Lys Phe Arg Leu Pro Glu Ile 
305                 310                 315                 320 


Ser Arg Phe Ser Ala Glu Phe Asp Phe Arg Thr Tyr Asp Ser Glu Gly 
                325                 330                 335     


Val Ile Leu Tyr Ala Glu Ser Ile Asp His Ser Ala Trp Leu Leu Ile 
            340                 345                 350         


Ala Leu Arg Gly Gly Lys Ile Glu Val Gln Leu Lys Asn Glu His Thr 
        355                 360                 365             


Ser Lys Ile Thr Thr Gly Gly Asp Val Ile Asn Asn Gly Leu Trp Asn 
    370                 375                 380                 


Met Val Ser Val Glu Glu Leu Glu His Ser Ile Ser Ile Lys Ile Ala 
385                 390                 395                 400 


Lys Glu Ala Val Met Asp Ile Asn Lys Pro Gly Pro Leu Phe Lys Pro 
                405                 410                 415     


Glu Asn Gly Leu Leu Glu Thr Lys Val Tyr Phe Ala Gly Phe Pro Arg 
            420                 425                 430         


Lys Val Glu Ser Glu Leu Ile Lys Pro Ile Asn Pro Arg Leu Asp Gly 
        435                 440                 445             


Cys Ile Arg Ser Trp Asn Leu Met Lys Gln Gly Ala Ser Gly Ile Lys 
    450                 455                 460                 


Glu Ile Ile Gln Glu Lys Gln Asn Lys His Cys Leu Val Thr Val Glu 
465                 470                 475                 480 


Lys Gly Ser Tyr Tyr Pro Gly Ser Gly Ile Ala Gln Phe His Ile Asp 
                485                 490                 495     


Tyr Asn Asn Val Ser Ser Ala Glu Gly Trp His Val Asn Val Thr Leu 
            500                 505                 510         


Asn Ile Arg Pro Ser Thr Gly Thr Gly Val Met Leu Ala Leu Val Ser 
        515                 520                 525             


Gly Asn Asn Thr Val Pro Phe Ala Val Ser Leu Val Asp Ser Thr Ser 
    530                 535                 540                 


Glu Lys Ser Gln Asp Ile Leu Leu Ser Val Glu Asn Thr Val Ile Tyr 
545                 550                 555                 560 


Arg Ile Gln Ala Leu Ser Leu Cys Ser Asp Gln Gln Ser His Leu Glu 
                565                 570                 575     


Phe Arg Val Asn Arg Asn Asn Leu Glu Leu Ser Thr Pro Leu Lys Ile 
            580                 585                 590         


Glu Thr Ile Ser His Glu Asp Leu Gln Arg Gln Leu Ala Val Leu Asp 
        595                 600                 605             


Lys Ala Met Lys Ala Lys Val Ala Thr Tyr Leu Gly Gly Leu Pro Asp 
    610                 615                 620                 


Val Pro Phe Ser Ala Thr Pro Val Asn Ala Phe Tyr Asn Gly Cys Met 
625                 630                 635                 640 


Glu Val Asn Ile Asn Gly Val Gln Leu Asp Leu Asp Glu Ala Ile Ser 
                645                 650                 655     


Lys His Asn Asp Ile Arg Ala His Ser Cys Pro Ser Val Trp Lys Lys 
            660                 665                 670         


Thr Lys Asn Ser 
        675     


<210>  303
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Cys Ser Gly Ser Gly Arg Arg Arg Ser Ser Leu Ser Pro Thr Met 
1               5                   10                  15      


Arg Pro Gly Thr Gly Ala Glu Arg Gly Gly Leu Met Met Gly His Pro 
            20                  25                  30          


Gly Met His Tyr Ala Pro Met Gly Met His Pro Met Gly Gln Arg Ala 
        35                  40                  45              


Asn Met Pro Pro Val Pro His Gly Met Met Pro Gln Met Met Pro Pro 
    50                  55                  60                  


Met Gly Gly Pro Pro Met Gly Gln Met Pro Gly Met Met Ser Ser Val 
65                  70                  75                  80  


Met Pro Gly Met Met Met Ser His Met Ser Gln Ala Ser Met Gln Pro 
                85                  90                  95      


Ala Leu Pro Pro Gly Val Asn Ser Met Asp Val Ala Ala Gly Thr Ala 
            100                 105                 110         


Ser Gly Ala Lys Ser Met Trp Thr Glu His Lys Ser Pro Asp Gly Arg 
        115                 120                 125             


Thr Tyr Tyr Tyr Asn Thr Glu Thr Lys Gln Ser Thr Trp Glu Lys Pro 
    130                 135                 140                 


Asp Asp Leu Lys Thr Pro Ala Glu Gln Leu Leu Ser Lys Cys Pro Trp 
145                 150                 155                 160 


Lys Glu Tyr Lys Ser Asp Ser Gly Lys Pro Tyr Tyr Tyr Asn Ser Gln 
                165                 170                 175     


Thr Lys Glu Ser Arg Trp Ala Lys Pro Lys Glu Leu Glu Asp Leu Glu 
            180                 185                 190         


Gly Tyr Gln Asn Thr Ile Val Ala Gly Ser Leu Ile Thr Lys Ser Asn 
        195                 200                 205             


Leu His Ala Met Ile Lys Ala Glu Glu Ser Ser Lys Gln Glu Glu Cys 
    210                 215                 220                 


Thr Thr Thr Ser Thr Ala Pro Val Pro Thr Thr Glu Ile Pro Thr Thr 
225                 230                 235                 240 


Met Ser Thr Met Ala Ala Ala Glu Ala Ala Ala Ala Val Val Ala Ala 
                245                 250                 255     


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Asn Ala Asn Ala Ser 
            260                 265                 270         


Thr Ser Ala Ser Asn Thr Val Ser Gly Thr Val Pro Val Val Pro Glu 
        275                 280                 285             


Pro Glu Val Thr Ser Ile Val Ala Thr Val Val Asp Asn Glu Asn Thr 
    290                 295                 300                 


Val Thr Ile Ser Thr Glu Glu Gln Ala Gln Leu Thr Ser Thr Pro Ala 
305                 310                 315                 320 


Ile Gln Asp Gln Ser Val Glu Val Ser Ser Asn Thr Gly Glu Glu Thr 
                325                 330                 335     


Ser Lys Gln Glu Thr Val Ala Asp Phe Thr Pro Lys Lys Glu Glu Glu 
            340                 345                 350         


Glu Ser Gln Pro Ala Lys Lys Thr Tyr Thr Trp Asn Thr Lys Glu Glu 
        355                 360                 365             


Ala Lys Gln Ala Phe Lys Glu Leu Leu Lys Glu Lys Arg Val Pro Ser 
    370                 375                 380                 


Asn Ala Ser Trp Glu Gln Ala Met Lys Met Ile Ile Asn Asp Pro Arg 
385                 390                 395                 400 


Tyr Ser Ala Leu Ala Lys Leu Ser Glu Lys Lys Gln Ala Phe Asn Ala 
                405                 410                 415     


Tyr Lys Val Gln Thr Glu Lys Glu Glu Lys Glu Glu Ala Arg Ser Lys 
            420                 425                 430         


Tyr Lys Glu Ala Lys Glu Ser Phe Gln Arg Phe Leu Glu Asn His Glu 
        435                 440                 445             


Lys Met Thr Ser Thr Thr Arg Tyr Lys Lys Ala Glu Gln Met Phe Gly 
    450                 455                 460                 


Glu Met Glu Val Trp Asn Ala Ile Ser Glu Arg Asp Arg Leu Glu Ile 
465                 470                 475                 480 


Tyr Glu Asp Val Leu Phe Phe Leu Ser Lys Lys Glu Lys Glu Gln Ala 
                485                 490                 495     


Lys Gln Leu Arg Lys Arg Asn Trp Glu Ala Leu Lys Asn Ile Leu Asp 
            500                 505                 510         


Asn Met Ala Asn Val Thr Tyr Ser Thr Thr Trp Ser Glu Ala Gln Gln 
        515                 520                 525             


Tyr Leu Met Asp Asn Pro Thr Phe Ala Glu Asp Glu Glu Leu Gln Asn 
    530                 535                 540                 


Met Asp Lys Glu Asp Ala Leu Ile Cys Phe Glu Glu His Ile Arg Ala 
545                 550                 555                 560 


Leu Glu Lys Glu Glu Glu Glu Glu Lys Gln Lys Ser Leu Leu Arg Glu 
                565                 570                 575     


Arg Arg Arg Gln Arg Lys Asn Arg Glu Ser Phe Gln Ile Phe Leu Asp 
            580                 585                 590         


Glu Leu His Glu His Gly Gln Leu His Ser Met Ser Ser Trp Met Glu 
        595                 600                 605             


Leu Tyr Pro Thr Ile Ser Ser Asp Ile Arg Phe Thr Asn Met Leu Gly 
    610                 615                 620                 


Gln Pro Gly Ser Thr Ala Leu Asp Leu Phe Lys Phe Tyr Val Glu Asp 
625                 630                 635                 640 


Leu Lys Ala Arg Tyr His Asp Glu Lys Lys Ile Ile Lys Asp Ile Leu 
                645                 650                 655     


Lys Asp Lys Gly Phe Val Val Glu Val Asn Thr Thr Phe Glu Asp Phe 
            660                 665                 670         


Val Ala Ile Ile Ser Ser Thr Lys Arg Ser Thr Thr Leu Asp Ala Gly 
        675                 680                 685             


Asn Ile Lys Leu Ala Phe Asn Ser Leu Leu Glu Lys Ala Glu Ala Arg 
    690                 695                 700                 


Glu Arg Glu Arg Glu Lys Glu Glu Ala Arg Lys Met Lys Arg Lys Glu 
705                 710                 715                 720 


Ser Ala Phe Lys Ser Met Leu Lys Gln Ala Ala Pro Pro Ile Glu Leu 
                725                 730                 735     


Asp Ala Val Trp Glu Asp Ile Arg Glu Arg Phe Val Lys Glu Pro Ala 
            740                 745                 750         


Phe Glu Asp Ile Thr Leu Glu Ser Glu Arg Lys Arg Ile Phe Lys Asp 
        755                 760                 765             


Phe Met His Val Leu Glu His Glu Cys Gln His His His Ser Lys Asn 
    770                 775                 780                 


Lys Lys His Ser Lys Lys Ser Lys Lys His His Arg Lys Arg Ser Arg 
785                 790                 795                 800 


Ser Arg Ser Gly Ser Asp Ser Asp Asp Asp Asp Ser His Ser Lys Lys 
                805                 810                 815     


Lys Arg Gln Arg Ser Glu Ser Arg Ser Ala Ser Glu His Ser Ser Ser 
            820                 825                 830         


Ala Glu Ser Glu Arg Ser Tyr Lys Lys Ser Lys Lys His Lys Lys Lys 
        835                 840                 845             


Ser Lys Lys Arg Arg His Lys Ser Asp Ser Pro Glu Ser Asp Ala Glu 
    850                 855                 860                 


Arg Glu Lys Asp Lys Lys Glu Lys Asp Arg Glu Ser Glu Lys Asp Arg 
865                 870                 875                 880 


Thr Arg Gln Arg Ser Glu Ser Lys His Lys Ser Pro Lys Lys Lys Thr 
                885                 890                 895     


Gly Lys Asp Ser Gly Asn Trp Asp Thr Ser Gly Ser Glu Leu Ser Glu 
            900                 905                 910         


Gly Glu Leu Glu Lys Arg Arg Arg Thr Leu Leu Glu Gln Leu Asp Asp 
        915                 920                 925             


Asp Gln 
    930 


<210>  304
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Phe Thr Leu Leu Val Leu Leu Ser Gln Leu Pro Thr Val Thr Leu 
1               5                   10                  15      


Gly Phe Pro His Cys Ala Arg Gly Pro Lys Ala Ser Lys His Ala Gly 
            20                  25                  30          


Glu Glu Val Phe Thr Ser Lys Glu Glu Ala Asn Phe Phe Ile His Arg 
        35                  40                  45              


Arg Leu Leu Tyr Asn Arg Phe Asp Leu Glu Leu Phe Thr Pro Gly Asn 
    50                  55                  60                  


Leu Glu Arg Glu Cys Asn Glu Glu Leu Cys Asn Tyr Glu Glu Ala Arg 
65                  70                  75                  80  


Glu Ile Phe Val Asp Glu Asp Lys Thr Ile Ala Phe Trp Gln Glu Tyr 
                85                  90                  95      


Ser Ala Lys Gly Pro Thr Thr Lys Ser Asp Gly Asn Arg Glu Lys Ile 
            100                 105                 110         


Asp Val Met Gly Leu Leu Thr Gly Leu Ile Ala Ala Gly Val Phe Leu 
        115                 120                 125             


Val Ile Phe Gly Leu Leu Gly Tyr Tyr Leu Cys Ile Thr Lys Cys Asn 
    130                 135                 140                 


Arg Leu Gln His Pro Cys Ser Ser Ala Val Tyr Glu Arg Gly Arg His 
145                 150                 155                 160 


Thr Pro Ser Ile Ile Phe Arg Arg Pro Glu Glu Ala Ala Leu Ser Pro 
                165                 170                 175     


Leu Pro Pro Ser Val Glu Asp Ala Gly Leu Pro Ser Tyr Glu Gln Ala 
            180                 185                 190         


Val Ala Leu Thr Arg Lys His Ser Val Ser Pro Pro Pro Pro Tyr Pro 
        195                 200                 205             


Gly His Thr Lys Gly Phe Arg Val Phe Lys Lys Ser Met Ser Leu Pro 
    210                 215                 220                 


Ser His 
225     


<210>  305
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Glu Ala Phe Leu Gly Ser Arg Ser Gly Leu Trp Ala Gly Gly Pro 
1               5                   10                  15      


Ala Pro Gly Gln Phe Tyr Arg Ile Pro Ser Thr Pro Asp Ser Phe Met 
            20                  25                  30          


Asp Pro Ala Ser Ala Leu Tyr Arg Gly Pro Ile Thr Arg Thr Gln Asn 
        35                  40                  45              


Pro Met Val Thr Gly Thr Ser Val Leu Gly Val Lys Phe Glu Gly Gly 
    50                  55                  60                  


Val Val Ile Ala Ala Asp Met Leu Gly Ser Tyr Gly Ser Leu Ala Arg 
65                  70                  75                  80  


Phe Arg Asn Ile Ser Arg Ile Met Arg Val Asn Asn Ser Thr Met Leu 
                85                  90                  95      


Gly Ala Ser Gly Asp Tyr Ala Asp Phe Gln Tyr Leu Lys Gln Val Leu 
            100                 105                 110         


Gly Gln Met Val Ile Asp Glu Glu Leu Leu Gly Asp Gly His Ser Tyr 
        115                 120                 125             


Ser Pro Arg Ala Ile His Ser Trp Leu Thr Arg Ala Met Tyr Ser Arg 
    130                 135                 140                 


Arg Ser Lys Met Asn Pro Leu Trp Asn Thr Met Val Ile Gly Gly Tyr 
145                 150                 155                 160 


Ala Asp Gly Glu Ser Phe Leu Gly Tyr Val Asp Met Leu Gly Val Ala 
                165                 170                 175     


Tyr Glu Ala Pro Ser Leu Ala Thr Gly Tyr Gly Ala Tyr Leu Ala Gln 
            180                 185                 190         


Pro Leu Leu Arg Glu Val Leu Glu Lys Gln Pro Val Leu Ser Gln Thr 
        195                 200                 205             


Glu Ala Arg Asp Leu Val Glu Arg Cys Met Arg Val Leu Tyr Tyr Arg 
    210                 215                 220                 


Asp Ala Arg Ser Tyr Asn Arg Phe Gln Ile Ala Thr Val Thr Glu Lys 
225                 230                 235                 240 


Gly Val Glu Ile Glu Gly Pro Leu Ser Thr Glu Thr Asn Trp Asp Ile 
                245                 250                 255     


Ala His Met Ile Ser Gly Phe Glu 
            260                 


<210>  306
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Thr Arg Ser Leu Phe Lys Gly Asn Phe Trp Ser Ala Asp Ile Leu 
1               5                   10                  15      


Ser Thr Ile Gly Tyr Asp Asn Ile Ile Gln His Leu Asn Asn Gly Arg 
            20                  25                  30          


Lys Asn Cys Lys Glu Phe Glu Asp Phe Leu Lys Glu Arg Ala Ala Ile 
        35                  40                  45              


Glu Glu Arg Tyr Gly Lys Asp Leu Leu Asn Leu Ser Arg Lys Lys Pro 
    50                  55                  60                  


Cys Gly Gln Ser Glu Ile Asn Thr Leu Lys Arg Ala Leu Glu Val Phe 
65                  70                  75                  80  


Lys Gln Gln Val Asp Asn Val Ala Gln Cys His Ile Gln Leu Ala Gln 
                85                  90                  95      


Ser Leu Arg Glu Glu Ala Arg Lys Met Glu Glu Phe Arg Glu Lys Gln 
            100                 105                 110         


Lys Leu Gln Arg Lys Lys Thr Glu Leu Ile Met Asp Ala Ile His Lys 
        115                 120                 125             


Gln Lys Ser Leu Gln Phe Lys Lys Thr Met Asp Ala Lys Lys Asn Tyr 
    130                 135                 140                 


Glu Gln Lys Cys Arg Asp Lys Asp Glu Ala Glu Gln Ala Val Ser Arg 
145                 150                 155                 160 


Ser Ala Asn Leu Val Asn Pro Lys Gln Gln Glu Lys Leu Phe Val Lys 
                165                 170                 175     


Leu Ala Thr Ser Lys Thr Ala Val Glu Asp Ser Asp Lys Ala Tyr Met 
            180                 185                 190         


Leu His Ile Gly Thr Leu Asp Lys Val Arg Glu Glu Trp Gln Ser Glu 
        195                 200                 205             


His Ile Lys Ala Cys Glu Ala Phe Glu Ala Gln Glu Cys Glu Arg Ile 
    210                 215                 220                 


Asn Phe Phe Arg Asn Ala Leu Trp Leu His Val Asn Gln Leu Ser Gln 
225                 230                 235                 240 


Gln Cys Val Thr Ser Asp Glu Met Tyr Glu Gln Val Arg Lys Ser Leu 
                245                 250                 255     


Glu Met Cys Ser Ile Gln Arg Asp Ile Glu Tyr Phe Val Asn Gln Arg 
            260                 265                 270         


Lys Thr Gly Gln Ile Pro Pro Ala Pro Ile Met Tyr Glu Asn Phe Tyr 
        275                 280                 285             


Ser Ser Gln Lys Asn Ala Val Pro Ala Gly Lys Ala Thr Gly Pro Asn 
    290                 295                 300                 


Leu Ala Arg Arg Gly Pro Leu Pro Ile Pro Lys Ser Ser Pro Asp Asp 
305                 310                 315                 320 


Pro Asn Tyr Ser Leu Val Asp Asp Tyr Ser Leu Leu Tyr Gln 
                325                 330                 


<210>  307
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Pro Thr Thr Ile Glu Arg Glu Phe Glu Glu Leu Asp Thr Gln Arg 
1               5                   10                  15      


Arg Trp Gln Pro Leu Tyr Leu Glu Ile Arg Asn Glu Ser His Asp Tyr 
            20                  25                  30          


Pro His Arg Val Ala Lys Phe Pro Glu Asn Arg Asn Arg Asn Arg Tyr 
        35                  40                  45              


Arg Asp Val Ser Pro Tyr Asp His Ser Arg Val Lys Leu Gln Asn Ala 
    50                  55                  60                  


Glu Asn Asp Tyr Ile Asn Ala Ser Leu Val Asp Ile Glu Glu Ala Gln 
65                  70                  75                  80  


Arg Ser Tyr Ile Leu Thr Gln Gly Pro Leu Pro Asn Thr Cys Cys His 
                85                  90                  95      


Phe Trp Leu Met Val Trp Gln Gln Lys Thr Lys Ala Val Val Met Leu 
            100                 105                 110         


Asn Arg Ile Val Glu Lys Glu Ser Val Lys Cys Ala Gln Tyr Trp Pro 
        115                 120                 125             


Thr Asp Asp Gln Glu Met Leu Phe Lys Glu Thr Gly Phe Ser Val Lys 
    130                 135                 140                 


Leu Leu Ser Glu Asp Val Lys Ser Tyr Tyr Thr Val His Leu Leu Gln 
145                 150                 155                 160 


Leu Glu Asn Ile Asn Ser Gly Glu Thr Arg Thr Ile Ser His Phe His 
                165                 170                 175     


Tyr Thr Thr Trp Pro Asp Phe Gly Val Pro Glu Ser Pro Ala Ser Phe 
            180                 185                 190         


Leu Asn Phe Leu Phe Lys Val Arg Glu Ser Gly Ser Leu Asn Pro Asp 
        195                 200                 205             


His Gly Pro Ala Val Ile His Cys Ser Ala Gly Ile Gly Arg Ser Gly 
    210                 215                 220                 


Thr Phe Ser Leu Val Asp Thr Cys Leu Val Leu Met Glu Lys Gly Asp 
225                 230                 235                 240 


Asp Ile Asn Ile Lys Gln Val Leu Leu Asn Met Arg Lys Tyr Arg Met 
                245                 250                 255     


Gly Leu Ile Gln Thr Pro Asp Gln Leu Arg Phe Ser Tyr Met Ala Ile 
            260                 265                 270         


Ile Glu Gly Ala Lys Cys Ile Lys Gly Asp Ser Ser Ile Gln Lys Arg 
        275                 280                 285             


Trp Lys Glu Leu Ser Lys Glu Asp Leu Ser Pro Ala Phe Asp His Ser 
    290                 295                 300                 


Pro Asn Lys Ile Met Thr Glu Lys Tyr Asn Gly Asn Arg Ile Gly Leu 
305                 310                 315                 320 


Glu Glu Glu Lys Leu Thr Gly Asp Arg Cys Thr Gly Leu Ser Ser Lys 
                325                 330                 335     


Met Gln Asp Thr Met Glu Glu Asn Ser Glu Ser Ala Leu Arg Lys Arg 
            340                 345                 350         


Ile Arg Glu Asp Arg Lys Ala Thr Thr Ala Gln Lys Val Gln Gln Met 
        355                 360                 365             


Lys Gln Arg Leu Asn Glu Asn Glu Arg Lys Arg Lys Arg Trp Leu Tyr 
    370                 375                 380                 


Trp Gln Pro Ile Leu Thr Lys Met Gly Phe Met Ser Val Ile Leu Val 
385                 390                 395                 400 


Gly Ala Phe Val Gly Trp Thr Leu Phe Phe Gln Gln Asn Ala Leu 
                405                 410                 415 


<210>  308
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Ala Tyr Asn Asp Thr Asp Arg Asn Gln Thr Glu Lys Leu Leu Lys 
1               5                   10                  15      


Arg Val Arg Glu Leu Glu Gln Glu Val Gln Arg Leu Lys Lys Glu Gln 
            20                  25                  30          


Ala Lys Asn Lys Glu Asp Ser Asn Ile Arg Glu Asn Ser Ala Gly Ala 
        35                  40                  45              


Gly Lys Thr Lys Arg Ala Phe Asp Phe Ser Ala His Gly Arg Arg His 
    50                  55                  60                  


Val Ala Leu Arg Ile Ala Tyr Met Gly Trp Gly Tyr Gln Gly Phe Ala 
65                  70                  75                  80  


Ser Gln Glu Asn Thr Asn Asn Thr Ile Glu Glu Lys Leu Phe Glu Ala 
                85                  90                  95      


Leu Thr Lys Thr Arg Leu Val Glu Ser Arg Gln Thr Ser Asn Tyr His 
            100                 105                 110         


Arg Cys Gly Arg Thr Asp Lys Gly Val Ser Ala Phe Gly Gln Val Ile 
        115                 120                 125             


Ser Leu Asp Leu Arg Ser Gln Phe Pro Arg Gly Arg Asp Ser Glu Asp 
    130                 135                 140                 


Phe Asn Val Lys Glu Glu Ala Asn Ala Ala Ala Glu Glu Ile Arg Tyr 
145                 150                 155                 160 


Thr His Ile Leu Asn Arg Val Leu Pro Pro Asp Ile Arg Ile Leu Ala 
                165                 170                 175     


Trp Ala Pro Val Glu Pro Ser Phe Ser Ala Arg Phe Ser Cys Leu Glu 
            180                 185                 190         


Arg Thr Tyr Arg Tyr Phe Phe Pro Arg Ala Asp Leu Asp Ile Val Thr 
        195                 200                 205             


Met Asp Tyr Ala Ala Gln Lys Tyr Val Gly Thr His Asp Phe Arg Asn 
    210                 215                 220                 


Leu Cys Lys Met Asp Val Ala Asn Gly Val Ile Asn Phe Gln Arg Thr 
225                 230                 235                 240 


Ile Leu Ser Ala Gln Val Gln Leu Val Gly Gln Ser Pro Gly Glu Gly 
                245                 250                 255     


Arg Trp Gln Glu Pro Phe Gln Leu Cys Gln Phe Glu Val Thr Gly Gln 
            260                 265                 270         


Ala Phe Leu Tyr His Gln Val Arg Cys Met Met Ala Ile Leu Phe Leu 
        275                 280                 285             


Ile Gly Gln Gly Met Glu Lys Pro Glu Ile Ile Asp Glu Leu Leu Asn 
    290                 295                 300                 


Ile Glu Lys Asn Pro Gln Lys Pro Gln Tyr Ser Met Ala Val Glu Phe 
305                 310                 315                 320 


Pro Leu Val Leu Tyr Asp Cys Lys Phe Glu Asn Val Lys Trp Ile Tyr 
                325                 330                 335     


Asp Gln Glu Ala Gln Glu Phe Asn Ile Thr His Leu Gln Gln Leu Trp 
            340                 345                 350         


Ala Asn His Ala Val Lys Thr His Met Leu Tyr Ser Met Leu Gln Gly 
        355                 360                 365             


Leu Asp Thr Val Pro Val Pro Cys Gly Ile Gly Pro Lys Met Asp Gly 
    370                 375                 380                 


Met Thr Glu Trp Gly Asn Val Lys Pro Ser Val Ile Lys Gln Thr Ser 
385                 390                 395                 400 


Ala Phe Val Glu Gly Val Lys Met Arg Thr Tyr Lys Pro Leu Met Asp 
                405                 410                 415     


Arg Pro Lys Cys Gln Gly Leu Glu Ser Arg Ile Gln His Phe Val Arg 
            420                 425                 430         


Arg Gly Arg Ile Glu His Pro His Leu Phe His Glu Glu Glu Thr Lys 
        435                 440                 445             


Ala Lys Arg Asp Cys Asn Asp Thr Leu Glu Glu Glu Asn Thr Asn Leu 
    450                 455                 460                 


Glu Thr Pro Thr Lys Arg Val Cys Val Asp Thr Glu Ile Lys Ser Ile 
465                 470                 475                 480 


Ile 
    


<210>  309
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Ser Leu Met Val Ser Ala Gly Arg Gly Leu Gly Ala Val Trp Ser 
1               5                   10                  15      


Pro Thr His Val Gln Val Thr Val Leu Gln Ala Arg Gly Leu Arg Ala 
            20                  25                  30          


Lys Gly Pro Gly Gly Thr Ser Asp Ala Tyr Ala Val Ile Gln Val Gly 
        35                  40                  45              


Lys Glu Lys Tyr Ala Thr Ser Val Ser Glu Arg Ser Leu Gly Ala Pro 
    50                  55                  60                  


Val Trp Arg Glu Glu Ala Thr Phe Glu Leu Pro Ser Leu Leu Ser Ser 
65                  70                  75                  80  


Gly Pro Ala Ala Ala Ala Thr Leu Gln Leu Thr Val Leu His Arg Ala 
                85                  90                  95      


Leu Leu Gly Leu Asp Lys Phe Leu Gly Arg Ala Glu Val Asp Leu Arg 
            100                 105                 110         


Asp Leu His Arg Asp Gln Gly Arg Arg Lys Thr Gln Trp Tyr Lys Leu 
        115                 120                 125             


Lys Ser Lys Pro Gly Lys Lys Asp Lys Glu Arg Gly Glu Ile Glu Val 
    130                 135                 140                 


Asp Ile Gln Phe Met Arg Asn Asn Met Thr Ala Ser Met Phe Asp Leu 
145                 150                 155                 160 


Ser Met Lys Asp Lys Ser Arg Asn Pro Phe Gly Lys Leu Lys Asp Lys 
                165                 170                 175     


Ile Lys Gly Lys Asn Lys Asp Ser Gly Ser Asp Thr Ala Ser Ala Ile 
            180                 185                 190         


Ile Pro Ser Thr Thr Pro Ser Val Asp Ser Asp Asp Glu Ser Val Val 
        195                 200                 205             


Lys Asp Lys Lys Lys Lys Ser Lys Ile Lys Thr Leu Leu Ser Lys Ser 
    210                 215                 220                 


Asn Leu Gln Lys Thr Pro Leu Ser Gln Ser Met Ser Val Leu Pro Thr 
225                 230                 235                 240 


Ser Lys Pro Glu Lys Val Leu Leu Arg Pro Gly Asp Phe Gln Ser Gln 
                245                 250                 255     


Trp Asp Glu Asp Asp Asn Glu Asp Glu Ser Ser Ser Ala Ser Asp Val 
            260                 265                 270         


Met Ser His Lys Arg Thr Ala Ser Thr Asp Leu Lys Gln Leu Asn Gln 
        275                 280                 285             


Val Asn Phe Thr Leu Pro Lys Lys Glu Gly Leu Ser Phe Leu Gly Gly 
    290                 295                 300                 


Leu Arg Ser Lys Asn Asp Val Leu Ser Arg Ser Asn Val Cys Ile Asn 
305                 310                 315                 320 


Gly Asn His Val Tyr Leu Glu Gln Pro Glu Ala Lys Gly Glu Ile Lys 
                325                 330                 335     


Asp Ser Ser Pro Ser Ser Ser Pro Ser Pro Lys Gly Phe Arg Lys Lys 
            340                 345                 350         


His Leu Phe Ser Ser Thr Glu Asn Leu Ala Ala Gly Ser Trp Lys Glu 
        355                 360                 365             


Pro Ala Glu Gly Gly Gly Leu Ser Ser Asp Arg Gln Leu Ser Glu Ser 
    370                 375                 380                 


Ser Thr Lys Asp Ser Leu Lys Ser Met Thr Leu Pro Ser Tyr Arg Pro 
385                 390                 395                 400 


Ala Pro Leu Val Ser Gly Asp Leu Arg Glu Asn Met Ala Pro Ala Asn 
                405                 410                 415     


Ser Glu Ala Thr Lys Glu Ala Lys Glu Ser Lys Lys Pro Glu Ser Arg 
            420                 425                 430         


Arg Ser Ser Leu Leu Ser Leu Met Thr Gly Lys Lys Asp Val Ala Lys 
        435                 440                 445             


Gly Ser Glu Gly Glu Asn Pro Leu Thr Val Pro Gly Arg Glu Lys Glu 
    450                 455                 460                 


Gly Met Leu Met Gly Val Lys Pro Gly Glu Asp Ala Ser Gly Pro Ala 
465                 470                 475                 480 


Glu Asp Leu Val Arg Arg Ser Glu Lys Asp Thr Ala Ala Val Val Ser 
                485                 490                 495     


Arg Gln Gly Ser Ser Leu Asn Leu Phe Glu Asp Val Gln Ile Thr Glu 
            500                 505                 510         


Pro Glu Ala Glu Pro Glu Ser Lys Ser Glu Pro Arg Pro Pro Ile Ser 
        515                 520                 525             


Ser Pro Arg Ala Pro Gln Thr Arg Ala Val Lys Pro Arg Leu His Pro 
    530                 535                 540                 


Val Lys Pro Met Asn Ala Met Ala Thr Lys Val Ala Asn Cys Ser Leu 
545                 550                 555                 560 


Gly Thr Ala Thr Ile Ile Ser Glu Asn Leu Asn Asn Glu Val Met Met 
                565                 570                 575     


Lys Lys Tyr Ser Pro Ser Asp Pro Ala Phe Ala Tyr Ala Gln Leu Thr 
            580                 585                 590         


His Asp Glu Leu Ile Gln Leu Val Leu Lys Gln Lys Glu Thr Ile Ser 
        595                 600                 605             


Lys Lys Glu Phe Gln Val Arg Glu Leu Glu Asp Tyr Ile Asp Asn Leu 
    610                 615                 620                 


Leu Val Arg Val Met Glu Glu Thr Pro Asn Ile Leu Arg Ile Pro Thr 
625                 630                 635                 640 


Gln Val Gly Lys Lys Ala Gly Lys Met 
                645                 


<210>  310
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Ser Ala Pro Pro Ala Ser Pro Pro Gly Ser Glu Pro Pro Gly 
1               5                   10                  15      


Pro Asp Pro Glu Pro Gly Gly Pro Asp Gly Pro Gly Ala Ala Gln Leu 
            20                  25                  30          


Ala Pro Gly Pro Ala Glu Leu Arg Leu Gly Ala Pro Val Gly Gly Pro 
        35                  40                  45              


Asp Pro Gln Ser Pro Gly Leu Asp Glu Pro Ala Pro Gly Ala Ala Ala 
    50                  55                  60                  


Asp Gly Gly Ala Arg Trp Ser Ala Gly Pro Ala Pro Gly Leu Glu Gly 
65                  70                  75                  80  


Gly Pro Arg Asp Pro Gly Pro Ser Ala Pro Pro Pro Arg Ser Gly Pro 
                85                  90                  95      


Arg Gly Gln Leu Ala Ser Pro Asp Ala Pro Gly Pro Gly Pro Arg Ser 
            100                 105                 110         


Glu Ala Pro Leu Pro Glu Leu Asp Pro Leu Phe Ser Trp Thr Glu Glu 
        115                 120                 125             


Pro Glu Glu Cys Gly Pro Ala Ser Cys Pro Glu Ser Ala Pro Phe Arg 
    130                 135                 140                 


Leu Gln Gly Ser Ser Ser Ser His Arg Ala Arg Gly Glu Val Asp Val 
145                 150                 155                 160 


Phe Ser Pro Phe Pro Ala Pro Thr Ala Gly Glu Leu Ala Leu Glu Gln 
                165                 170                 175     


Gly Pro Gly Ser Pro Pro Gln Pro Ser Asp Leu Ser Gln Thr His Pro 
            180                 185                 190         


Leu Pro Ser Glu Pro Val Gly Ser Gln Glu Asp Gly Pro Arg Leu Arg 
        195                 200                 205             


Ala Val Phe Asp Ala Leu Asp Gly Asp Gly Asp Gly Phe Val Arg Ile 
    210                 215                 220                 


Glu Asp Phe Ile Gln Phe Ala Thr Val Tyr Gly Ala Glu Gln Val Lys 
225                 230                 235                 240 


Asp Leu Thr Lys Tyr Leu Asp Pro Ser Gly Leu Gly Val Ile Ser Phe 
                245                 250                 255     


Glu Asp Phe Tyr Gln Gly Ile Thr Ala Ile Arg Asn Gly Asp Pro Asp 
            260                 265                 270         


Gly Gln Cys Tyr Gly Gly Val Ala Ser Ala Gln Asp Glu Glu Pro Leu 
        275                 280                 285             


Ala Cys Pro Asp Glu Phe Asp Asp Phe Val Thr Tyr Glu Ala Asn Glu 
    290                 295                 300                 


Val Thr Asp Ser Ala Tyr Met Gly Ser Glu Ser Thr Tyr Ser Glu Cys 
305                 310                 315                 320 


Glu Thr Phe Thr Asp Glu Asp Thr Ser Thr Leu Val His Pro Glu Leu 
                325                 330                 335     


Gln Pro Glu Gly Asp Ala Asp Ser Ala Gly Gly Ser Ala Val Pro Ser 
            340                 345                 350         


Glu Cys Leu Asp Ala Met Glu Glu Pro Asp His Gly Ala Leu Leu Leu 
        355                 360                 365             


Leu Pro Gly Arg Pro His Pro His Gly Gln Ser Val Ile Thr Val Ile 
    370                 375                 380                 


Gly Gly Glu Glu His Phe Glu Asp Tyr Gly Glu Gly Ser Glu Ala Glu 
385                 390                 395                 400 


Leu Ser Pro Glu Thr Leu Cys Asn Gly Gln Leu Gly Cys Ser Asp Pro 
                405                 410                 415     


Ala Phe Leu Thr Pro Ser Pro Thr Lys Arg Leu Ser Ser Lys Lys Val 
            420                 425                 430         


Ala Arg Tyr Leu His Gln Ser Gly Ala Leu Thr Met Glu Ala Leu Glu 
        435                 440                 445             


Asp Pro Ser Pro Glu Leu Met Glu Gly Pro Glu Glu Asp Ile Ala Asp 
    450                 455                 460                 


Lys Val Val Phe Leu Glu Arg Arg Val Leu Glu Leu Glu Lys Asp Thr 
465                 470                 475                 480 


Ala Ala Thr Gly Glu Gln His Ser Arg Leu Arg Gln Glu Asn Leu Gln 
                485                 490                 495     


Leu Val His Arg Ala Asn Ala Leu Glu Glu Gln Leu Lys Glu Gln Glu 
            500                 505                 510         


Leu Arg Ala Cys Glu Met Val Leu Glu Glu Thr Arg Arg Gln Lys Glu 
        515                 520                 525             


Leu Leu Cys Lys Met Glu Arg Glu Lys Ser Ile Glu Ile Glu Asn Leu 
    530                 535                 540                 


Gln Thr Arg Leu Gln Gln Leu Asp Glu Glu Asn Ser Glu Leu Arg Ser 
545                 550                 555                 560 


Cys Thr Pro Cys Leu Lys Ala Asn Ile Glu Arg Leu Glu Glu Glu Lys 
                565                 570                 575     


Gln Lys Leu Leu Asp Glu Ile Glu Ser Leu Thr Leu Arg Leu Ser Glu 
            580                 585                 590         


Glu Gln Glu Asn Lys Arg Arg Met Gly Asp Arg Leu Ser His Glu Arg 
        595                 600                 605             


His Gln Phe Gln Arg Asp Lys Glu Ala Thr Gln Glu Leu Ile Glu Asp 
    610                 615                 620                 


Leu Arg Lys Gln Leu Glu His Leu Gln Leu Leu Lys Leu Glu Ala Glu 
625                 630                 635                 640 


Gln Arg Arg Gly Arg Ser Ser Ser Met Gly Leu Gln Glu Tyr His Ser 
                645                 650                 655     


Arg Ala Arg Glu Ser Glu Leu Glu Gln Glu Val Arg Arg Leu Lys Gln 
            660                 665                 670         


Asp Asn Arg Asn Leu Lys Glu Gln Asn Glu Glu Leu Asn Gly Gln Ile 
        675                 680                 685             


Ile Thr Leu Ser Ile Gln Gly Ala Lys Ser Leu Phe Ser Thr Ala Phe 
    690                 695                 700                 


Ser Glu Ser Leu Ala Ala Glu Ile Ser Ser Val Ser Arg Asp Glu Leu 
705                 710                 715                 720 


Met Glu Ala Ile Gln Lys Gln Glu Glu Ile Asn Phe Arg Leu Gln Asp 
                725                 730                 735     


Tyr Ile Asp Arg Ile Ile Val Ala Ile Met Glu Thr Asn Pro Ser Ile 
            740                 745                 750         


Leu Glu Val Lys 
        755     


<210>  311
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Ala Gly Lys Ser Ser Leu Phe Lys Val Ile Leu Leu Gly Asp Gly 
1               5                   10                  15      


Gly Val Gly Lys Ser Ser Leu Met Asn Arg Tyr Val Thr Asn Lys Phe 
            20                  25                  30          


Asp Thr Gln Leu Phe His Thr Ile Gly Val Glu Phe Leu Asn Lys Asp 
        35                  40                  45              


Leu Glu Val Asp Gly His Phe Val Thr Met Gln Ile Trp Asp Thr Ala 
    50                  55                  60                  


Gly Gln Glu Arg Phe Arg Ser Leu Arg Thr Pro Phe Tyr Arg Gly Ser 
65                  70                  75                  80  


Asp Cys Cys Leu Leu Thr Phe Ser Val Asp Asp Ser Gln Ser Phe Gln 
                85                  90                  95      


Asn Leu Ser Asn Trp Lys Lys Glu Phe Ile Tyr Tyr Ala Asp Val Lys 
            100                 105                 110         


Glu Pro Glu Ser Phe Pro Phe Val Ile Leu Gly Asn Lys Ile Asp Ile 
        115                 120                 125             


Ser Glu Arg Gln Val Ser Thr Glu Glu Ala Gln Ala Trp Cys Arg Asp 
    130                 135                 140                 


Asn Gly Asp Tyr Pro Tyr Phe Glu Thr Ser Ala Lys Asp Ala Thr Asn 
145                 150                 155                 160 


Val Ala Ala Ala Phe Glu Glu Ala Val Arg Arg Val Leu Ala Thr Glu 
                165                 170                 175     


Asp Arg Ser Asp His Leu Ile Gln Thr Asp Thr Val Asn Leu His Arg 
            180                 185                 190         


Lys Pro Lys Pro Ser Ser Ser Cys Cys 
        195                 200     


<210>  312
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Ala Ala Ala Thr Ala Asp Pro Gly Ala Gly Asn Pro Gln Pro Gly 
1               5                   10                  15      


Asp Ser Ser Gly Gly Gly Ala Gly Gly Gly Leu Pro Ser Pro Gly Glu 
            20                  25                  30          


Gln Glu Leu Ser Arg Arg Leu Gln Arg Leu Tyr Pro Ala Val Asn Gln 
        35                  40                  45              


Gln Glu Thr Pro Leu Pro Arg Ser Trp Ser Pro Lys Asp Lys Tyr Asn 
    50                  55                  60                  


Tyr Ile Gly Leu Ser Gln Gly Asn Leu Arg Val His Tyr Lys Gly His 
65                  70                  75                  80  


Gly Lys Asn His Lys Asp Ala Ala Ser Val Arg Ala Thr His Pro Ile 
                85                  90                  95      


Pro Ala Ala Cys Gly Ile Tyr Tyr Phe Glu Val Lys Ile Val Ser Lys 
            100                 105                 110         


Gly Arg Asp Gly Tyr Met Gly Ile Gly Leu Ser Ala Gln Gly Val Asn 
        115                 120                 125             


Met Asn Arg Leu Pro Gly Trp Asp Lys His Ser Tyr Gly Tyr His Gly 
    130                 135                 140                 


Asp Asp Gly His Ser Phe Cys Ser Ser Gly Thr Gly Gln Pro Tyr Gly 
145                 150                 155                 160 


Pro Thr Phe Thr Thr Gly Asp Val Ile Gly Cys Cys Val Asn Leu Ile 
                165                 170                 175     


Asn Gly Thr Cys Phe Tyr Thr Lys Asn Gly His Ser Leu Gly Ile Ala 
            180                 185                 190         


Phe Thr Asp Leu Pro Ala Asn Leu Tyr Pro Thr Val Gly Leu Gln Thr 
        195                 200                 205             


Pro Gly Glu Ile Val Asp Ala Asn Phe Gly Gln Gln Pro Phe Leu Phe 
    210                 215                 220                 


Asp Ile Glu Asp Tyr Met Arg Glu Trp Arg Ala Lys Val Gln Gly Thr 
225                 230                 235                 240 


Val His Cys Phe Pro Ile Ser Ala Arg Leu Gly Glu Trp Gln Ala Val 
                245                 250                 255     


Leu Gln Asn Met Val Ser Ser Tyr Leu Val His His Gly Tyr Cys Ala 
            260                 265                 270         


Thr Ala Thr Ala Phe Ala Arg Met Thr Glu Thr Pro Ile Gln Glu Glu 
        275                 280                 285             


Gln Ala Ser Ile Lys Asn Arg Gln Lys Ile Gln Lys Leu Val Leu Glu 
    290                 295                 300                 


Gly Arg Val Gly Glu Ala Ile Glu Thr Thr Gln Arg Phe Tyr Pro Gly 
305                 310                 315                 320 


Leu Leu Glu His Asn Pro Asn Leu Leu Phe Met Leu Lys Cys Arg Gln 
                325                 330                 335     


Phe Val Glu Met Val Asn Gly Thr Asp Ser Glu Val Arg Ser Leu Ser 
            340                 345                 350         


Ser Arg Ser Pro Lys Ser Gln Asp Ser Tyr Pro Gly Ser Pro Ser Leu 
        355                 360                 365             


Ser Pro Arg His Gly Pro Ser Ser Ser His Met His Asn Thr Gly Ala 
    370                 375                 380                 


Asp Ser Pro Ser Cys Ser Asn Gly Val Ala Ser Thr Lys Ser Lys Gln 
385                 390                 395                 400 


Asn His Ser Lys Tyr Pro Ala Pro Ser Ser Ser Ser Ser Ser Ser Ser 
                405                 410                 415     


Ser Ser Ser Ser Ser Ser Pro Ser Ser Val Asn Tyr Ser Glu Ser Asn 
            420                 425                 430         


Ser Thr Asp Ser Thr Lys Ser Gln His His Ser Ser Thr Ser Asn Gln 
        435                 440                 445             


Glu Thr Ser Asp Ser Glu Met Glu Met Glu Ala Glu His Tyr Pro Asn 
    450                 455                 460                 


Gly Val Leu Gly Ser Met Ser Thr Arg Ile Val Asn Gly Ala Tyr Lys 
465                 470                 475                 480 


His Glu Asp Leu Gln Thr Asp Glu Ser Ser Met Asp Asp Arg His Pro 
                485                 490                 495     


Arg Arg Gln Leu Cys Gly Gly Asn Gln Ala Ala Thr Glu Arg Ile Ile 
            500                 505                 510         


Leu Phe Gly Arg Glu Leu Gln Ala Leu Ser Glu Gln Leu Gly Arg Glu 
        515                 520                 525             


Tyr Gly Lys Asn Leu Ala His Thr Glu Met Leu Gln Asp Ala Phe Ser 
    530                 535                 540                 


Leu Leu Ala Tyr Ser Asp Pro Trp Ser Cys Pro Val Gly Gln Gln Leu 
545                 550                 555                 560 


Asp Pro Ile Gln Arg Glu Pro Val Cys Ala Ala Leu Asn Ser Ala Ile 
                565                 570                 575     


Leu Glu Ser Gln Asn Leu Pro Lys Gln Pro Pro Leu Met Leu Ala Leu 
            580                 585                 590         


Gly Gln Ala Ser Glu Cys Leu Arg Leu Met Ala Arg Ala Gly Leu Gly 
        595                 600                 605             


Ser Cys Ser Phe Ala Arg Val Asp Asp Tyr Leu His 
    610                 615                 620 


<210>  313
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Ala Gly Thr Leu Asp Leu Asp Lys Gly Cys Thr Val Glu Glu Leu 
1               5                   10                  15      


Leu Arg Gly Cys Ile Glu Ala Phe Asp Asp Ser Gly Lys Val Arg Asp 
            20                  25                  30          


Pro Gln Leu Val Arg Met Phe Leu Met Met His Pro Trp Tyr Ile Pro 
        35                  40                  45              


Ser Ser Gln Leu Ala Ala Lys Leu Leu His Ile Tyr Gln Gln Ser Arg 
    50                  55                  60                  


Lys Asp Asn Ser Asn Ser Leu Gln Val Lys Thr Cys His Leu Val Arg 
65                  70                  75                  80  


Tyr Trp Ile Ser Ala Phe Pro Ala Glu Phe Asp Leu Asn Pro Glu Leu 
                85                  90                  95      


Ala Glu Gln Ile Lys Glu Leu Lys Ala Leu Leu Asp Gln Glu Gly Asn 
            100                 105                 110         


Arg Arg His Ser Ser Leu Ile Asp Ile Asp Ser Val Pro Thr Tyr Lys 
        115                 120                 125             


Trp Lys Arg Gln Val Thr Gln Arg Asn Pro Val Gly Gln Lys Lys Arg 
    130                 135                 140                 


Lys Met Ser Leu Leu Phe Asp His Leu Glu Pro Met Glu Leu Ala Glu 
145                 150                 155                 160 


His Leu Thr Tyr Leu Glu Tyr Arg Ser Phe Cys Lys Ile Leu Phe Gln 
                165                 170                 175     


Asp Tyr His Ser Phe Val Thr His Gly Cys Thr Val Asp Asn Pro Val 
            180                 185                 190         


Leu Glu Arg Phe Ile Ser Leu Phe Asn Ser Val Ser Gln Trp Val Gln 
        195                 200                 205             


Leu Met Ile Leu Ser Lys Pro Thr Ala Pro Gln Arg Ala Leu Val Ile 
    210                 215                 220                 


Thr His Phe Val His Val Ala Glu Lys Leu Leu Gln Leu Gln Asn Phe 
225                 230                 235                 240 


Asn Thr Leu Met Ala Val Val Gly Gly Leu Ser His Ser Ser Ile Ser 
                245                 250                 255     


Arg Leu Lys Glu Thr His Ser His Val Ser Pro Glu Thr Ile Lys Leu 
            260                 265                 270         


Trp Glu Gly Leu Thr Glu Leu Val Thr Ala Thr Gly Asn Tyr Gly Asn 
        275                 280                 285             


Tyr Arg Arg Arg Leu Ala Ala Cys Val Gly Phe Arg Phe Pro Ile Leu 
    290                 295                 300                 


Gly Val His Leu Lys Asp Leu Val Ala Leu Gln Leu Ala Leu Pro Asp 
305                 310                 315                 320 


Trp Leu Asp Pro Ala Arg Thr Arg Leu Asn Gly Ala Lys Met Lys Gln 
                325                 330                 335     


Leu Phe Ser Ile Leu Glu Glu Leu Ala Met Val Thr Ser Leu Arg Pro 
            340                 345                 350         


Pro Val Gln Ala Asn Pro Asp Leu Leu Ser Leu Leu Thr Val Ser Leu 
        355                 360                 365             


Asp Gln Tyr Gln Thr Glu Asp Glu Leu Tyr Gln Leu Ser Leu Gln Arg 
    370                 375                 380                 


Glu Pro Arg Ser Lys Ser Ser Pro Thr Ser Pro Thr Ser Cys Thr Pro 
385                 390                 395                 400 


Pro Pro Arg Pro Pro Val Leu Glu Glu Trp Thr Ser Ala Ala Lys Pro 
                405                 410                 415     


Lys Leu Asp Gln Ala Leu Val Val Glu His Ile Glu Lys Met Val Glu 
            420                 425                 430         


Ser Val Phe Arg Asn Phe Asp Val Asp Gly Asp Gly His Ile Ser Gln 
        435                 440                 445             


Glu Glu Phe Gln Ile Ile Arg Gly Asn Phe Pro Tyr Leu Ser Ala Phe 
    450                 455                 460                 


Gly Asp Leu Asp Gln Asn Gln Asp Gly Cys Ile Ser Arg Glu Glu Met 
465                 470                 475                 480 


Val Ser Tyr Phe Leu Arg Ser Ser Ser Val Leu Gly Gly Arg Met Gly 
                485                 490                 495     


Phe Val His Asn Phe Gln Glu Ser Asn Ser Leu Arg Pro Val Ala Cys 
            500                 505                 510         


Arg His Cys Lys Ala Leu Ile Leu Gly Ile Tyr Lys Gln Gly Leu Lys 
        515                 520                 525             


Cys Arg Ala Cys Gly Val Asn Cys His Lys Gln Cys Lys Asp Arg Leu 
    530                 535                 540                 


Ser Val Glu Cys Arg Arg Arg Ala Gln Ser Val Ser Leu Glu Gly Ser 
545                 550                 555                 560 


Ala Pro Ser Pro Ser Pro Met His Ser His His His Arg Ala Phe Ser 
                565                 570                 575     


Phe Ser Leu Pro Arg Pro Gly Arg Arg Gly Ser Arg Pro Pro Glu Ile 
            580                 585                 590         


Arg Glu Glu Glu Val Gln Thr Val Glu Asp Gly Val Phe Asp Ile His 
        595                 600                 605             


Leu 
    


<210>  314
<211>  689
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Gly Ser Ser Gly Leu Gly Lys Ala Ala Thr Leu Asp Glu Leu Leu 
1               5                   10                  15      


Cys Thr Cys Ile Glu Met Phe Asp Asp Asn Gly Glu Leu Asp Asn Ser 
            20                  25                  30          


Tyr Leu Pro Arg Ile Val Leu Leu Met His Arg Trp Tyr Leu Ser Ser 
        35                  40                  45              


Thr Glu Leu Ala Glu Lys Leu Leu Cys Met Tyr Arg Asn Ala Thr Gly 
    50                  55                  60                  


Glu Ser Cys Asn Glu Phe Arg Leu Lys Ile Cys Tyr Phe Met Arg Tyr 
65                  70                  75                  80  


Trp Ile Leu Lys Phe Pro Ala Glu Phe Asn Leu Asp Leu Gly Leu Ile 
                85                  90                  95      


Arg Met Thr Glu Glu Phe Arg Glu Val Ala Ser Gln Leu Gly Tyr Glu 
            100                 105                 110         


Lys His Val Ser Leu Ile Asp Ile Ser Ser Ile Pro Ser Tyr Asp Trp 
        115                 120                 125             


Met Arg Arg Val Thr Gln Arg Lys Lys Val Ser Lys Lys Gly Lys Ala 
    130                 135                 140                 


Cys Leu Leu Phe Asp His Leu Glu Pro Ile Glu Leu Ala Glu His Leu 
145                 150                 155                 160 


Thr Phe Leu Glu His Lys Ser Phe Arg Arg Ile Ser Phe Thr Asp Tyr 
                165                 170                 175     


Gln Ser Tyr Val Ile His Gly Cys Leu Glu Asn Asn Pro Thr Leu Glu 
            180                 185                 190         


Arg Ser Ile Ala Leu Phe Asn Gly Ile Ser Lys Trp Val Gln Leu Met 
        195                 200                 205             


Val Leu Ser Lys Pro Thr Pro Gln Gln Arg Ala Glu Val Ile Thr Lys 
    210                 215                 220                 


Phe Ile Asn Val Ala Lys Lys Leu Leu Gln Leu Lys Asn Phe Asn Thr 
225                 230                 235                 240 


Leu Met Ala Val Val Gly Gly Leu Ser His Ser Ser Ile Ser Arg Leu 
                245                 250                 255     


Lys Glu Thr His Ser His Leu Ser Ser Glu Val Thr Lys Asn Trp Asn 
            260                 265                 270         


Glu Met Thr Glu Leu Val Ser Ser Asn Gly Asn Tyr Cys Asn Tyr Arg 
        275                 280                 285             


Lys Ala Phe Ala Asp Cys Asp Gly Phe Lys Ile Pro Ile Leu Gly Val 
    290                 295                 300                 


His Leu Lys Asp Leu Ile Ala Val His Val Ile Phe Pro Asp Trp Thr 
305                 310                 315                 320 


Glu Glu Asn Lys Val Asn Ile Val Lys Met His Gln Leu Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Leu Val Ser Leu Gln Asn Ala Ser His His Leu Glu Pro 
            340                 345                 350         


Asn Met Asp Leu Ile Asn Leu Leu Thr Leu Ser Leu Asp Leu Tyr His 
        355                 360                 365             


Thr Glu Asp Asp Ile Tyr Lys Leu Ser Leu Val Leu Glu Pro Arg Asn 
    370                 375                 380                 


Ser Lys Ser Pro Thr Ser Pro Thr Thr Pro Asn Lys Pro Val Val Pro 
385                 390                 395                 400 


Leu Glu Trp Ala Leu Gly Val Met Pro Lys Pro Asp Pro Thr Val Ile 
                405                 410                 415     


Asn Lys His Ile Arg Lys Leu Val Glu Ser Val Phe Arg Asn Tyr Asp 
            420                 425                 430         


His Asp His Asp Gly Tyr Ile Ser Gln Glu Asp Phe Glu Ser Ile Ala 
        435                 440                 445             


Ala Asn Phe Pro Phe Leu Asp Ser Phe Cys Val Leu Asp Lys Asp Gln 
    450                 455                 460                 


Asp Gly Leu Ile Ser Lys Asp Glu Met Met Ala Tyr Phe Leu Arg Ala 
465                 470                 475                 480 


Lys Ser Gln Leu His Cys Lys Met Gly Pro Gly Phe Ile His Asn Phe 
                485                 490                 495     


Gln Glu Met Thr Tyr Leu Lys Pro Thr Phe Cys Glu His Cys Ala Gly 
            500                 505                 510         


Phe Leu Trp Gly Ile Ile Lys Gln Gly Tyr Lys Cys Lys Asp Cys Gly 
        515                 520                 525             


Ala Asn Cys His Lys Gln Cys Lys Asp Leu Leu Val Leu Ala Cys Arg 
    530                 535                 540                 


Arg Phe Ala Arg Ala Pro Ser Leu Ser Ser Gly His Gly Ser Leu Pro 
545                 550                 555                 560 


Gly Ser Pro Ser Leu Pro Pro Ala Gln Asp Glu Val Phe Glu Phe Pro 
                565                 570                 575     


Gly Val Thr Ala Gly His Arg Asp Leu Asp Ser Arg Ala Ile Thr Leu 
            580                 585                 590         


Val Thr Gly Ser Ser Arg Lys Ile Ser Val Arg Leu Gln Arg Ala Thr 
        595                 600                 605             


Thr Ser Gln Ala Thr Gln Thr Glu Pro Val Trp Ser Glu Ala Gly Trp 
    610                 615                 620                 


Gly Asp Ser Gly Ser His Thr Phe Pro Lys Met Lys Ser Lys Phe His 
625                 630                 635                 640 


Asp Lys Ala Ala Lys Asp Lys Gly Phe Ala Lys Trp Glu Asn Glu Lys 
                645                 650                 655     


Pro Arg Val His Ala Gly Val Asp Val Val Asp Arg Gly Thr Glu Phe 
            660                 665                 670         


Glu Leu Asp Gln Asp Glu Gly Glu Glu Thr Arg Gln Asp Gly Glu Asp 
        675                 680                 685             


Gly 
    


<210>  315
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Leu Leu Gly Leu Ala Ala Met Glu Leu Lys Val Trp Val Asp Gly 
1               5                   10                  15      


Ile Gln Arg Val Val Cys Gly Val Ser Glu Gln Thr Thr Cys Gln Glu 
            20                  25                  30          


Val Val Ile Ala Leu Ala Gln Ala Ile Gly Gln Thr Gly Arg Phe Val 
        35                  40                  45              


Leu Val Gln Arg Leu Arg Glu Lys Glu Arg Gln Leu Leu Pro Gln Glu 
    50                  55                  60                  


Cys Pro Val Gly Ala Gln Ala Thr Cys Gly Gln Phe Ala Ser Asp Val 
65                  70                  75                  80  


Gln Phe Val Leu Arg Arg Thr Gly Ala Ser Leu Ala Gly Arg Pro Ser 
                85                  90                  95      


Ser Asp Ser Cys Pro Pro Pro Glu Arg Cys Leu Ile Arg Ala Ser Leu 
            100                 105                 110         


Pro Val Lys Pro Arg Ala Ala Leu Gly Cys Glu Pro Arg Lys Thr Leu 
        115                 120                 125             


Thr Pro Glu Pro Ala Pro Ser Leu Ser Arg Pro Gly Pro Ala Ala Pro 
    130                 135                 140                 


Val Thr Pro Thr Pro Gly Cys Cys Thr Asp Leu Arg Gly Leu Glu Leu 
145                 150                 155                 160 


Arg Val Gln Arg Asn Ala Glu Glu Leu Gly His Glu Ala Phe Trp Glu 
                165                 170                 175     


Gln Glu Leu Arg Arg Glu Gln Ala Arg Glu Arg Glu Gly Gln Ala Arg 
            180                 185                 190         


Leu Gln Ala Leu Ser Ala Ala Thr Ala Glu His Ala Ala Arg Leu Gln 
        195                 200                 205             


Ala Leu Asp Ala Gln Ala Arg Ala Leu Glu Ala Glu Leu Gln Leu Ala 
    210                 215                 220                 


Ala Glu Ala Pro Gly Pro Pro Ser Pro Met Ala Ser Ala Thr Glu Arg 
225                 230                 235                 240 


Leu His Gln Asp Leu Ala Val Gln Glu Arg Gln Ser Ala Glu Val Gln 
                245                 250                 255     


Gly Ser Leu Ala Leu Val Ser Arg Ala Leu Glu Ala Ala Glu Arg Ala 
            260                 265                 270         


Leu Gln Ala Gln Ala Gln Glu Leu Glu Glu Leu Asn Arg Glu Leu Arg 
        275                 280                 285             


Gln Cys Asn Leu Gln Gln Phe Ile Gln Gln Thr Gly Ala Ala Leu Pro 
    290                 295                 300                 


Pro Pro Pro Arg Pro Asp Arg Gly Pro Pro Gly Thr Gln Gly Pro Leu 
305                 310                 315                 320 


Pro Pro Ala Arg Glu Glu Ser Leu Leu Gly Ala Pro Ser Glu Ser His 
                325                 330                 335     


Ala Gly Ala Gln Pro Arg Pro Arg Gly Gly Pro His Asp Ala Glu Leu 
            340                 345                 350         


Leu Glu Val Ala Ala Ala Pro Ala Pro Glu Trp Cys Pro Leu Ala Ala 
        355                 360                 365             


Gln Pro Gln Ala Leu 
    370             


<210>  316
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Val Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Val Asp Ser Lys Gly Tyr Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Gln Gln Asp Val Lys Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Phe Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Glu 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Ala Ile Leu Asn 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asn Lys Glu Ile His Lys Pro 
    130                 135                 140                 


Gly Tyr Leu Ala Asn Asp Arg Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Thr Lys Glu Gln Trp Glu Glu Arg Ile Gln Asn Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ser Met Met Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu His Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Ala Gln Leu Glu Asn Glu Lys Lys Lys Arg Glu Ile Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Arg Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Ile Lys Ala Gln Lys Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Lys Ala Leu Glu Leu Asp Gln Glu Arg Lys Arg Ala Lys Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Lys Glu Arg Arg Ala Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Ser Ala Ile Ala Lys Gln Ala Ala Asp Gln Met Lys Asn Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Phe Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Lys Lys Lys Lys Glu Glu Glu Ala Thr Glu Trp Gln His Lys 
        435                 440                 445             


Ala Phe Ala Ala Gln Glu Asp Leu Glu Lys Thr Lys Glu Glu Leu Lys 
    450                 455                 460                 


Thr Val Met Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Val Ile Pro 
465                 470                 475                 480 


Pro Thr Glu Asn Glu His Asp Glu His Asp Glu Asn Asn Ala Glu Ala 
                485                 490                 495     


Ser Ala Glu Leu Ser Asn Glu Gly Val Met Asn His Arg Ser Glu Glu 
            500                 505                 510         


Glu Arg Val Thr Glu Thr Gln Lys Asn Glu Arg Val Lys Lys Gln Leu 
        515                 520                 525             


Gln Ala Leu Ser Ser Glu Leu Ala Gln Ala Arg Asp Glu Thr Lys Lys 
    530                 535                 540                 


Thr Gln Asn Asp Val Leu His Ala Glu Asn Val Lys Ala Gly Arg Asp 
545                 550                 555                 560 


Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg 
                565                 570                 575     


Ile Asp Glu Phe Glu Ala Met 
            580             


<210>  317
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Val Leu Cys Phe Pro Leu Leu Leu Leu Leu Leu Val Leu Trp Gly 
1               5                   10                  15      


Pro Val Cys Pro Leu His Ala Trp Pro Lys Arg Leu Thr Lys Ala His 
            20                  25                  30          


Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro Leu Gln Cys Asn Arg 
        35                  40                  45              


Ala Met Ser Gly Ile Asn Asn Tyr Thr Gln His Cys Lys His Gln Asn 
    50                  55                  60                  


Thr Phe Leu His Asp Ser Phe Gln Asn Val Ala Ala Val Cys Asp Leu 
65                  70                  75                  80  


Leu Ser Ile Val Cys Lys Asn Arg Arg His Asn Cys His Gln Ser Ser 
                85                  90                  95      


Lys Pro Val Asn Met Thr Asp Cys Arg Leu Thr Ser Gly Lys Tyr Pro 
            100                 105                 110         


Gln Cys Arg Tyr Ser Ala Ala Ala Gln Tyr Lys Phe Phe Ile Val Ala 
        115                 120                 125             


Cys Asp Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu Val Pro Val 
    130                 135                 140                 


His Leu Asp Ser Ile Leu 
145                 150 


<210>  318
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Lys Ala Gly Ala Thr Ser Met Trp Ala Ser Cys Cys Gly Leu Leu 
1               5                   10                  15      


Asn Glu Val Met Gly Thr Gly Ala Val Arg Gly Gln Gln Ser Ala Phe 
            20                  25                  30          


Ala Gly Ala Thr Gly Pro Phe Arg Phe Thr Pro Asn Pro Glu Phe Ser 
        35                  40                  45              


Thr Tyr Pro Pro Ala Ala Thr Glu Gly Pro Asn Ile Val Cys Lys Ala 
    50                  55                  60                  


Cys Gly Leu Ser Phe Ser Val Phe Arg Lys Lys His Val Cys Cys Asp 
65                  70                  75                  80  


Cys Lys Lys Asp Phe Cys Ser Val Cys Ser Val Leu Gln Glu Asn Leu 
                85                  90                  95      


Arg Arg Cys Ser Thr Cys His Leu Leu Gln Glu Thr Ala Phe Gln Arg 
            100                 105                 110         


Pro Gln Leu Met Arg Leu Lys Val Lys Asp Leu Arg Gln Tyr Leu Ile 
        115                 120                 125             


Leu Arg Asn Ile Pro Ile Asp Thr Cys Arg Glu Lys Glu Asp Leu Val 
    130                 135                 140                 


Asp Leu Val Leu Cys His His Gly Leu Gly Ser Glu Asp Asp Met Asp 
145                 150                 155                 160 


Thr Ser Ser Leu Asn Ser Ser Arg Ser Gln Thr Ser Ser Phe Phe Thr 
                165                 170                 175     


Arg Ser Phe Phe Ser Asn Tyr Thr Ala Pro Ser Ala Thr Met Ser Ser 
            180                 185                 190         


Phe Gln Gly Glu Leu Met Asp Gly Asp Gln Thr Ser Arg Ser Gly Val 
        195                 200                 205             


Pro Ala Gln Val Gln Ser Glu Ile Thr Ser Ala Asn Thr Glu Asp Asp 
    210                 215                 220                 


Asp Asp Asp Asp Asp Glu Asp Asp Asp Asp Glu Glu Glu Asn Ala Glu 
225                 230                 235                 240 


Asp Arg Asn Pro Gly Leu Ser Lys Glu Arg Val Arg Ala Ser Leu Ser 
                245                 250                 255     


Asp Leu Ser Ser Leu Asp Asp Val Glu Gly Met Ser Val Arg Gln Leu 
            260                 265                 270         


Lys Glu Ile Leu Ala Arg Asn Phe Val Asn Tyr Ser Gly Cys Cys Glu 
        275                 280                 285             


Lys Trp Glu Leu Val Glu Lys Val Asn Arg Leu Tyr Lys Glu Asn Glu 
    290                 295                 300                 


Glu Asn Gln Lys Ser Tyr Gly Glu Arg Leu Gln Leu Gln Asp Glu Glu 
305                 310                 315                 320 


Asp Asp Ser Leu Cys Arg Ile Cys Met Asp Ala Val Ile Asp Cys Val 
                325                 330                 335     


Leu Leu Glu Cys Gly His Met Val Thr Cys Thr Lys Cys Gly Lys Arg 
            340                 345                 350         


Met Ser Glu Cys Pro Ile Cys Arg Gln Tyr Val Val Arg Ala Val His 
        355                 360                 365             


Val Phe Lys Ser 
    370         


<210>  319
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Trp Asn Ser Gly Phe Glu Ser Tyr Gly Ser Ser Ser Tyr Gly Gly 
1               5                   10                  15      


Ala Gly Gly Tyr Thr Gln Ser Pro Gly Gly Phe Gly Ser Pro Ala Pro 
            20                  25                  30          


Ser Gln Ala Glu Lys Lys Ser Arg Ala Arg Ala Gln His Ile Val Pro 
        35                  40                  45              


Cys Thr Ile Ser Gln Leu Leu Ser Ala Thr Leu Val Asp Glu Val Phe 
    50                  55                  60                  


Arg Ile Gly Asn Val Glu Ile Ser Gln Val Thr Ile Val Gly Ile Ile 
65                  70                  75                  80  


Arg His Ala Glu Lys Ala Pro Thr Asn Ile Val Tyr Lys Ile Asp Asp 
                85                  90                  95      


Met Thr Ala Ala Pro Met Asp Val Arg Gln Trp Val Asp Thr Asp Asp 
            100                 105                 110         


Thr Ser Ser Glu Asn Thr Val Val Pro Pro Glu Thr Tyr Val Lys Val 
        115                 120                 125             


Ala Gly His Leu Arg Ser Phe Gln Asn Lys Lys Ser Leu Val Ala Phe 
    130                 135                 140                 


Lys Ile Met Pro Leu Glu Asp Met Asn Glu Phe Thr Thr His Ile Leu 
145                 150                 155                 160 


Glu Val Ile Asn Ala His Met Val Leu Ser Lys Ala Asn Ser Gln Pro 
                165                 170                 175     


Ser Ala Gly Arg Ala Pro Ile Ser Asn Pro Gly Met Ser Glu Ala Gly 
            180                 185                 190         


Asn Phe Gly Gly Asn Ser Phe Met Pro Ala Asn Gly Leu Thr Val Ala 
        195                 200                 205             


Gln Asn Gln Val Leu Asn Leu Ile Lys Ala Cys Pro Arg Pro Glu Gly 
    210                 215                 220                 


Leu Asn Phe Gln Asp Leu Lys Asn Gln Leu Lys His Met Ser Val Ser 
225                 230                 235                 240 


Ser Ile Lys Gln Ala Val Asp Phe Leu Ser Asn Glu Gly His Ile Tyr 
                245                 250                 255     


Ser Thr Val Asp Asp Asp His Phe Lys Ser Thr Asp Ala Glu 
            260                 265                 270 


<210>  320
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Ala Ala Val Phe Asp Leu Asp Leu Glu Thr Glu Glu Gly Ser Glu 
1               5                   10                  15      


Gly Glu Gly Glu Pro Glu Leu Ser Pro Ala Asp Ala Cys Pro Leu Ala 
            20                  25                  30          


Glu Leu Arg Ala Ala Gly Leu Glu Pro Val Gly His Tyr Glu Glu Val 
        35                  40                  45              


Glu Leu Thr Glu Thr Ser Val Asn Val Gly Pro Glu Arg Ile Gly Pro 
    50                  55                  60                  


His Cys Phe Glu Leu Leu Arg Val Leu Gly Lys Gly Gly Tyr Gly Lys 
65                  70                  75                  80  


Val Phe Gln Val Arg Lys Val Gln Gly Thr Asn Leu Gly Lys Ile Tyr 
                85                  90                  95      


Ala Met Lys Val Leu Arg Lys Ala Lys Ile Val Arg Asn Ala Lys Asp 
            100                 105                 110         


Thr Ala His Thr Arg Ala Glu Arg Asn Ile Leu Glu Ser Val Lys His 
        115                 120                 125             


Pro Phe Ile Val Glu Leu Ala Tyr Ala Phe Gln Thr Gly Gly Lys Leu 
    130                 135                 140                 


Tyr Leu Ile Leu Glu Cys Leu Ser Gly Gly Glu Leu Phe Thr His Leu 
145                 150                 155                 160 


Glu Arg Glu Gly Ile Phe Leu Glu Asp Thr Ala Cys Phe Tyr Leu Ala 
                165                 170                 175     


Glu Ile Thr Leu Ala Leu Gly His Leu His Ser Gln Gly Ile Ile Tyr 
            180                 185                 190         


Arg Asp Leu Lys Pro Glu Asn Ile Met Leu Ser Ser Gln Gly His Ile 
        195                 200                 205             


Lys Leu Thr Asp Phe Gly Leu Cys Lys Glu Ser Ile His Glu Gly Ala 
    210                 215                 220                 


Val Thr His Thr Phe Cys Gly Thr Ile Glu Tyr Met Ala Pro Glu Ile 
225                 230                 235                 240 


Leu Val Arg Ser Gly His Asn Arg Ala Val Asp Trp Trp Ser Leu Gly 
                245                 250                 255     


Ala Leu Met Tyr Asp Met Leu Thr Gly Ser Pro Pro Phe Thr Ala Glu 
            260                 265                 270         


Asn Arg Lys Lys Thr Met Asp Lys Ile Ile Arg Gly Lys Leu Ala Leu 
        275                 280                 285             


Pro Pro Tyr Leu Thr Pro Asp Ala Arg Asp Leu Val Lys Lys Phe Leu 
    290                 295                 300                 


Lys Arg Asn Pro Ser Gln Arg Ile Gly Gly Gly Pro Gly Asp Ala Ala 
305                 310                 315                 320 


Asp Val Gln Arg His Pro Phe Phe Arg His Met Asn Trp Asp Asp Leu 
                325                 330                 335     


Leu Ala Trp Arg Val Asp Pro Pro Phe Arg Pro Cys Leu Gln Ser Glu 
            340                 345                 350         


Glu Asp Val Ser Gln Phe Asp Thr Arg Phe Thr Arg Gln Thr Pro Val 
        355                 360                 365             


Asp Ser Pro Asp Asp Thr Ala Leu Ser Glu Ser Ala Asn Gln Ala Phe 
    370                 375                 380                 


Leu Gly Phe Thr Tyr Val Ala Pro Ser Val Leu Asp Ser Ile Lys Glu 
385                 390                 395                 400 


Gly Phe Ser Phe Gln Pro Lys Leu Arg Ser Pro Arg Arg Leu Asn Ser 
                405                 410                 415     


Ser Pro Arg Ala Pro Val Ser Pro Leu Lys Phe Ser Pro Phe Glu Gly 
            420                 425                 430         


Phe Arg Pro Ser Pro Ser Leu Pro Glu Pro Thr Glu Leu Pro Leu Pro 
        435                 440                 445             


Pro Leu Leu Pro Pro Pro Pro Pro Ser Thr Thr Ala Pro Leu Pro Ile 
    450                 455                 460                 


Arg Pro Pro Ser Gly Thr Lys Lys Ser Lys Arg Gly Arg Gly Arg Pro 
465                 470                 475                 480 


Gly Arg 
        


<210>  321
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Gly Ile Ser Arg Asp Asn Trp His Lys Arg Arg Lys Thr Gly Gly 
1               5                   10                  15      


Lys Arg Lys Pro Tyr His Lys Lys Arg Lys Tyr Glu Leu Gly Arg Pro 
            20                  25                  30          


Ala Ala Asn Thr Lys Ile Gly Pro Arg Arg Ile His Thr Val Arg Val 
        35                  40                  45              


Arg Gly Gly Asn Lys Lys Tyr Arg Ala Leu Arg Leu Asp Val Gly Asn 
    50                  55                  60                  


Phe Ser Trp Gly Ser Glu Cys Cys Thr Arg Lys Thr Arg Ile Ile Asp 
65                  70                  75                  80  


Val Val Tyr Asn Ala Ser Asn Asn Glu Leu Val Arg Thr Lys Thr Leu 
                85                  90                  95      


Val Lys Asn Cys Ile Val Leu Ile Asp Ser Thr Pro Tyr Arg Gln Trp 
            100                 105                 110         


Tyr Glu Ser His Tyr Ala Leu Pro Leu Gly Arg Lys Lys Gly Ala Lys 
        115                 120                 125             


Leu Thr Pro Glu Glu Glu Glu Ile Leu Asn Lys Lys Arg Ser Lys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Tyr Asp Glu Arg Lys Lys Asn Ala Lys Ile Ser Ser 
145                 150                 155                 160 


Leu Leu Glu Glu Gln Phe Gln Gln Gly Lys Leu Leu Ala Cys Ile Ala 
                165                 170                 175     


Ser Arg Pro Gly Gln Cys Gly Arg Ala Asp Gly Tyr Val Leu Glu Gly 
            180                 185                 190         


Lys Glu Leu Glu Phe Tyr Leu Arg Lys Ile Lys Ala Arg Lys Gly Lys 
        195                 200                 205             


<210>  322
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Thr Lys Leu Glu Glu His Leu Glu Gly Ile Val Asn Ile Phe His 
1               5                   10                  15      


Gln Tyr Ser Val Arg Lys Gly His Phe Asp Thr Leu Ser Lys Gly Glu 
            20                  25                  30          


Leu Lys Gln Leu Leu Thr Lys Glu Leu Ala Asn Thr Ile Lys Asn Ile 
        35                  40                  45              


Lys Asp Lys Ala Val Ile Asp Glu Ile Phe Gln Gly Leu Asp Ala Asn 
    50                  55                  60                  


Gln Asp Glu Gln Val Asp Phe Gln Glu Phe Ile Ser Leu Val Ala Ile 
65                  70                  75                  80  


Ala Leu Lys Ala Ala His Tyr His Thr His Lys Glu 
                85                  90          


<210>  323
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Thr Glu Leu Glu Thr Ala Met Gly Met Ile Ile Asp Val Phe Ser 
1               5                   10                  15      


Arg Tyr Ser Gly Ser Glu Gly Ser Thr Gln Thr Leu Thr Lys Gly Glu 
            20                  25                  30          


Leu Lys Val Leu Met Glu Lys Glu Leu Pro Gly Phe Leu Gln Ser Gly 
        35                  40                  45              


Lys Asp Lys Asp Ala Val Asp Lys Leu Leu Lys Asp Leu Asp Ala Asn 
    50                  55                  60                  


Gly Asp Ala Gln Val Asp Phe Ser Glu Phe Ile Val Phe Val Ala Ala 
65                  70                  75                  80  


Ile Thr Ser Ala Cys His Lys Tyr Phe Glu Lys Ala Gly Leu Lys 
                85                  90                  95  


<210>  324
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Leu Arg Arg Lys Pro Ser Asn Ala Ser Glu Lys Glu Pro Thr Gln 
1               5                   10                  15      


Lys Lys Lys Leu Ser Leu Gln Arg Ser Ser Ser Phe Lys Asp Phe Ala 
            20                  25                  30          


Lys Ser Lys Pro Ser Ser Pro Val Val Ser Glu Lys Glu Phe Asn Leu 
        35                  40                  45              


Asp Asp Asn Ile Pro Glu Asp Asp Ser Gly Val Pro Thr Pro Glu Asp 
    50                  55                  60                  


Ala Gly Lys Ser Gly Lys Lys Leu Gly Lys Lys Trp Arg Ala Val Ile 
65                  70                  75                  80  


Ser Arg Thr Met Asn Arg Lys Met Gly Lys Met Met Val Lys Ala Leu 
                85                  90                  95      


Ser Glu Glu Met Ala Asp Thr Leu Glu Glu Gly Ser Ala Ser Pro Thr 
            100                 105                 110         


Ser Pro Asp Tyr Ser Leu Asp Ser Pro Gly Pro Glu Lys Met Ala Leu 
        115                 120                 125             


Ala Phe Ser Glu Gln Glu Glu His Glu Leu Pro Val Leu Ser Arg Gln 
    130                 135                 140                 


Ala Ser Thr Gly Ser Glu Leu Cys Ser Pro Ser Pro Gly Ser Gly Ser 
145                 150                 155                 160 


Phe Gly Glu Glu Pro Pro Ala Pro Gln Tyr Thr Gly Pro Phe Cys Gly 
                165                 170                 175     


Arg Ala Arg Val His Thr Asp Phe Thr Pro Ser Pro Tyr Asp His Asp 
            180                 185                 190         


Ser Leu Lys Leu Gln Lys Gly Asp Val Ile Gln Ile Ile Glu Lys Pro 
        195                 200                 205             


Pro Val Gly Thr Trp Leu Gly Leu Leu Asn Gly Lys Val Gly Ser Phe 
    210                 215                 220                 


Lys Phe Ile Tyr Val Asp Val Leu Pro Glu Glu Ala Val Gly His Ala 
225                 230                 235                 240 


Arg Pro Ser Arg Arg Gln Ser Lys Gly Lys Arg Pro Lys Pro Lys Thr 
                245                 250                 255     


Leu His Glu Leu Leu Glu Arg Ile Gly Leu Glu Glu His Thr Ser Thr 
            260                 265                 270         


Leu Leu Leu Asn Gly Tyr Gln Thr Leu Glu Asp Phe Lys Glu Leu Arg 
        275                 280                 285             


Glu Thr His Leu Asn Glu Leu Asn Ile Met Asp Pro Gln His Arg Ala 
    290                 295                 300                 


Lys Leu Leu Thr Ala Ala Glu Leu Leu Leu Asp Tyr Asp Thr Gly Ser 
305                 310                 315                 320 


Glu Glu Ala Glu Glu Gly Ala Glu Ser Ser Gln Glu Pro Val Ala His 
                325                 330                 335     


Thr Val Ser Glu Pro Lys Val Asp Ile Pro Arg Asp Ser Gly Cys Phe 
            340                 345                 350         


Glu Gly Ser Glu Ser Gly Arg Asp Asp Ala Glu Leu Ala Gly Thr Glu 
        355                 360                 365             


Glu Gln Leu Gln Gly Leu Ser Leu Ala Gly Ala Pro 
    370                 375                 380 


<210>  325
<211>  1893
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Ala Arg Leu Ala Asp Tyr Phe Val Leu Val Ala Phe Gly Pro His 
1               5                   10                  15      


Pro Arg Gly Ser Gly Glu Gly Gln Gly Gln Ile Leu Gln Arg Phe Pro 
            20                  25                  30          


Glu Lys Asp Trp Glu Asp Asn Pro Phe Pro Gln Gly Ile Glu Leu Phe 
        35                  40                  45              


Cys Gln Pro Ser Gly Trp Gln Leu Cys Pro Glu Arg Asn Pro Pro Thr 
    50                  55                  60                  


Phe Phe Val Ala Val Leu Thr Asp Ile Asn Ser Glu Arg His Tyr Cys 
65                  70                  75                  80  


Ala Cys Leu Thr Phe Trp Glu Pro Ala Glu Pro Ser Gln Glu Thr Thr 
                85                  90                  95      


Arg Val Glu Asp Ala Thr Glu Arg Glu Glu Glu Gly Asp Glu Gly Gly 
            100                 105                 110         


Gln Thr His Leu Ser Pro Thr Ala Pro Ala Pro Ser Ala Gln Leu Phe 
        115                 120                 125             


Ala Pro Lys Thr Leu Val Leu Val Ser Arg Leu Asp His Thr Glu Val 
    130                 135                 140                 


Phe Arg Asn Ser Leu Gly Leu Ile Tyr Ala Ile His Val Glu Gly Leu 
145                 150                 155                 160 


Asn Val Cys Leu Glu Asn Val Ile Gly Asn Leu Leu Thr Cys Thr Val 
                165                 170                 175     


Pro Leu Ala Gly Gly Ser Gln Arg Thr Ile Ser Leu Gly Ala Gly Asp 
            180                 185                 190         


Arg Gln Val Ile Gln Thr Pro Leu Ala Asp Ser Leu Pro Val Ser Arg 
        195                 200                 205             


Cys Ser Val Ala Leu Leu Phe Arg Gln Leu Gly Ile Thr Asn Val Leu 
    210                 215                 220                 


Ser Leu Phe Cys Ala Ala Leu Thr Glu His Lys Val Leu Phe Leu Ser 
225                 230                 235                 240 


Arg Ser Tyr Gln Arg Leu Ala Asp Ala Cys Arg Gly Leu Leu Ala Leu 
                245                 250                 255     


Leu Phe Pro Leu Arg Tyr Ser Phe Thr Tyr Val Pro Ile Leu Pro Ala 
            260                 265                 270         


Gln Leu Leu Glu Val Leu Ser Thr Pro Thr Pro Phe Ile Ile Gly Val 
        275                 280                 285             


Asn Ala Ala Phe Gln Ala Glu Thr Gln Glu Leu Leu Asp Val Ile Val 
    290                 295                 300                 


Ala Asp Leu Asp Gly Gly Thr Val Thr Ile Pro Glu Cys Val His Ile 
305                 310                 315                 320 


Pro Pro Leu Pro Glu Pro Leu Gln Ser Gln Thr His Ser Val Leu Ser 
                325                 330                 335     


Met Val Leu Asp Pro Glu Leu Glu Leu Ala Asp Leu Ala Phe Pro Pro 
            340                 345                 350         


Pro Thr Thr Ser Thr Ser Ser Leu Lys Met Gln Asp Lys Glu Leu Arg 
        355                 360                 365             


Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Leu Gln Gly Tyr Arg Trp 
    370                 375                 380                 


Cys Leu His Val Val Arg Ile His Pro Glu Pro Val Ile Arg Phe His 
385                 390                 395                 400 


Lys Ala Ala Phe Leu Gly Gln Arg Gly Leu Val Glu Asp Asp Phe Leu 
                405                 410                 415     


Met Lys Val Leu Glu Gly Met Ala Phe Ala Gly Phe Val Ser Glu Arg 
            420                 425                 430         


Gly Val Pro Tyr Arg Pro Thr Asp Leu Phe Asp Glu Leu Val Ala His 
        435                 440                 445             


Glu Val Ala Arg Met Arg Ala Asp Glu Asn His Pro Gln Arg Val Leu 
    450                 455                 460                 


Arg His Val Gln Glu Leu Ala Glu Gln Leu Tyr Lys Asn Glu Asn Pro 
465                 470                 475                 480 


Tyr Pro Ala Val Ala Met His Lys Val Gln Arg Pro Gly Glu Ser Ser 
                485                 490                 495     


His Leu Arg Arg Val Pro Arg Pro Phe Pro Arg Leu Asp Glu Gly Thr 
            500                 505                 510         


Val Gln Trp Ile Val Asp Gln Ala Ala Ala Lys Met Gln Gly Ala Pro 
        515                 520                 525             


Pro Ala Val Lys Ala Glu Arg Arg Thr Thr Val Pro Ser Gly Pro Pro 
    530                 535                 540                 


Met Thr Ala Ile Leu Glu Arg Cys Ser Gly Leu His Val Asn Ser Ala 
545                 550                 555                 560 


Arg Arg Leu Glu Val Val Arg Asn Cys Ile Ser Tyr Val Phe Glu Gly 
                565                 570                 575     


Lys Met Leu Glu Ala Lys Lys Leu Leu Pro Ala Val Leu Arg Ala Leu 
            580                 585                 590         


Lys Gly Arg Ala Ala Arg Arg Cys Leu Ala Gln Glu Leu His Leu His 
        595                 600                 605             


Val Gln Gln Asn Arg Ala Val Leu Asp His Gln Gln Phe Asp Phe Val 
    610                 615                 620                 


Val Arg Met Met Asn Cys Cys Leu Gln Asp Cys Thr Ser Leu Asp Glu 
625                 630                 635                 640 


His Gly Ile Ala Ala Ala Leu Leu Pro Leu Val Thr Ala Phe Cys Arg 
                645                 650                 655     


Lys Leu Ser Pro Gly Val Thr Gln Phe Ala Tyr Ser Cys Val Gln Glu 
            660                 665                 670         


His Val Val Trp Ser Thr Pro Gln Phe Trp Glu Ala Met Phe Tyr Gly 
        675                 680                 685             


Asp Val Gln Thr His Ile Arg Ala Leu Tyr Leu Glu Pro Thr Glu Asp 
    690                 695                 700                 


Leu Ala Pro Ala Gln Glu Val Gly Glu Ala Pro Ser Gln Glu Asp Glu 
705                 710                 715                 720 


Arg Ser Ala Leu Asp Val Ala Ser Glu Gln Arg Arg Leu Trp Pro Thr 
                725                 730                 735     


Leu Ser Arg Glu Lys Gln Gln Glu Leu Val Gln Lys Glu Glu Ser Thr 
            740                 745                 750         


Val Phe Ser Gln Ala Ile His Tyr Ala Asn Arg Met Ser Tyr Leu Leu 
        755                 760                 765             


Leu Pro Leu Asp Ser Ser Lys Ser Arg Leu Leu Arg Glu Arg Ala Gly 
    770                 775                 780                 


Leu Gly Asp Leu Glu Ser Ala Ser Asn Ser Leu Val Thr Asn Ser Met 
785                 790                 795                 800 


Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu Ser Gly Phe Glu Asp 
                805                 810                 815     


Ala Glu Thr Cys Asp Val Ala Gly Ala Val Val Arg Phe Ile Asn Arg 
            820                 825                 830         


Phe Val Asp Lys Val Cys Thr Glu Ser Gly Val Thr Ser Asp His Leu 
        835                 840                 845             


Lys Gly Leu His Val Met Val Pro Asp Ile Val Gln Met His Ile Glu 
    850                 855                 860                 


Thr Leu Glu Ala Val Gln Arg Glu Ser Arg Arg Leu Pro Pro Ile Gln 
865                 870                 875                 880 


Lys Pro Lys Leu Leu Arg Pro Arg Leu Leu Pro Gly Glu Glu Cys Val 
                885                 890                 895     


Leu Asp Gly Leu Arg Val Tyr Leu Leu Pro Asp Gly Arg Glu Glu Gly 
            900                 905                 910         


Ala Gly Gly Ser Ala Gly Gly Pro Ala Leu Leu Pro Ala Glu Gly Ala 
        915                 920                 925             


Val Phe Leu Thr Thr Tyr Arg Val Ile Phe Thr Gly Met Pro Thr Asp 
    930                 935                 940                 


Pro Leu Val Gly Glu Gln Val Val Val Arg Ser Phe Pro Val Ala Ala 
945                 950                 955                 960 


Leu Thr Lys Glu Lys Arg Ile Ser Val Gln Thr Pro Val Asp Gln Leu 
                965                 970                 975     


Leu Gln Asp Gly Leu Gln Leu Arg Ser Cys Thr Phe Gln Leu Leu Lys 
            980                 985                 990         


Met Ala Phe Asp Glu Glu Val Gly  Ser Asp Ser Ala Glu  Leu Phe Arg 
        995                 1000                 1005             


Lys Gln  Leu His Lys Leu Arg  Tyr Pro Pro Asp Ile  Arg Ala Thr 
    1010                 1015                 1020             


Phe Ala  Phe Thr Leu Gly Ser  Ala His Thr Pro Gly  Arg Pro Pro 
    1025                 1030                 1035             


Arg Val  Thr Lys Asp Lys Gly  Pro Ser Leu Arg Thr  Leu Ser Arg 
    1040                 1045                 1050             


Asn Leu  Val Lys Asn Ala Lys  Lys Thr Ile Gly Arg  Gln His Val 
    1055                 1060                 1065             


Thr Arg  Lys Lys Tyr Asn Pro  Pro Ser Trp Glu His  Arg Gly Gln 
    1070                 1075                 1080             


Pro Pro  Pro Glu Asp Gln Glu  Asp Glu Ile Ser Val  Ser Glu Glu 
    1085                 1090                 1095             


Leu Glu  Pro Ser Thr Leu Thr  Pro Ser Ser Ala Leu  Lys Pro Ser 
    1100                 1105                 1110             


Asp Arg  Met Thr Met Ser Ser  Leu Val Glu Arg Ala  Cys Cys Arg 
    1115                 1120                 1125             


Asp Tyr  Gln Arg Leu Gly Leu  Gly Thr Leu Ser Ser  Ser Leu Ser 
    1130                 1135                 1140             


Arg Ala  Lys Ser Glu Pro Phe  Arg Ile Ser Pro Val  Asn Arg Met 
    1145                 1150                 1155             


Tyr Ala  Ile Cys Arg Ser Tyr  Pro Gly Leu Leu Ile  Val Pro Gln 
    1160                 1165                 1170             


Ser Val  Gln Asp Asn Ala Leu  Gln Arg Val Ser Arg  Cys Tyr Arg 
    1175                 1180                 1185             


Gln Asn  Arg Phe Pro Val Val  Cys Trp Arg Ser Gly  Arg Ser Lys 
    1190                 1195                 1200             


Ala Val  Leu Leu Arg Ser Gly  Gly Leu His Gly Lys  Gly Val Val 
    1205                 1210                 1215             


Gly Leu  Phe Lys Ala Gln Asn  Ala Pro Ser Pro Gly  Gln Ser Gln 
    1220                 1225                 1230             


Ala Asp  Ser Ser Ser Leu Glu  Gln Glu Lys Tyr Leu  Gln Ala Val 
    1235                 1240                 1245             


Val Ser  Ser Met Pro Arg Tyr  Ala Asp Ala Ser Gly  Arg Asn Thr 
    1250                 1255                 1260             


Leu Ser  Gly Phe Ser Ser Ala  His Met Gly Ser His  Val Pro Ser 
    1265                 1270                 1275             


Pro Arg  Ala Arg Val Thr Thr  Leu Ser Asn Pro Met  Ala Ala Ser 
    1280                 1285                 1290             


Ala Ser  Arg Arg Thr Ala Pro  Arg Gly Lys Trp Gly  Ser Val Arg 
    1295                 1300                 1305             


Thr Ser  Gly Arg Ser Ser Gly  Leu Gly Thr Asp Val  Gly Ser Arg 
    1310                 1315                 1320             


Leu Ala  Gly Arg Asp Ala Leu  Ala Pro Pro Gln Ala  Asn Gly Gly 
    1325                 1330                 1335             


Pro Pro  Asp Pro Gly Phe Leu  Arg Pro Gln Arg Ala  Ala Leu Tyr 
    1340                 1345                 1350             


Ile Leu  Gly Asp Lys Ala Gln  Leu Lys Gly Val Arg  Ser Asp Pro 
    1355                 1360                 1365             


Leu Gln  Gln Trp Glu Leu Val  Pro Ile Glu Val Phe  Glu Ala Arg 
    1370                 1375                 1380             


Gln Val  Lys Ala Ser Phe Lys  Lys Leu Leu Lys Ala  Cys Val Pro 
    1385                 1390                 1395             


Gly Cys  Pro Ala Ala Glu Pro  Ser Pro Ala Ser Phe  Leu Arg Ser 
    1400                 1405                 1410             


Leu Glu  Asp Ser Glu Trp Leu  Ile Gln Ile His Lys  Leu Leu Gln 
    1415                 1420                 1425             


Val Ser  Val Leu Val Val Glu  Leu Leu Asp Ser Gly  Ser Ser Val 
    1430                 1435                 1440             


Leu Val  Gly Leu Glu Asp Gly  Trp Asp Ile Thr Thr  Gln Val Val 
    1445                 1450                 1455             


Ser Leu  Val Gln Leu Leu Ser  Asp Pro Phe Tyr Arg  Thr Leu Glu 
    1460                 1465                 1470             


Gly Phe  Arg Leu Leu Val Glu  Lys Glu Trp Leu Ser  Phe Gly His 
    1475                 1480                 1485             


Arg Phe  Ser His Arg Gly Ala  His Thr Leu Ala Gly  Gln Ser Ser 
    1490                 1495                 1500             


Gly Phe  Thr Pro Val Phe Leu  Gln Phe Leu Asp Cys  Val His Gln 
    1505                 1510                 1515             


Val His  Leu Gln Phe Pro Met  Glu Phe Glu Phe Ser  Gln Phe Tyr 
    1520                 1525                 1530             


Leu Lys  Phe Leu Gly Tyr His  His Val Ser Arg Arg  Phe Arg Thr 
    1535                 1540                 1545             


Phe Leu  Leu Asp Ser Asp Tyr  Glu Arg Ile Glu Leu  Gly Leu Leu 
    1550                 1555                 1560             


Tyr Glu  Glu Lys Gly Glu Arg  Arg Gly Gln Val Pro  Cys Arg Ser 
    1565                 1570                 1575             


Val Trp  Glu Tyr Val Asp Arg  Leu Ser Lys Arg Thr  Pro Val Phe 
    1580                 1585                 1590             


His Asn  Tyr Met Tyr Ala Pro  Glu Asp Ala Glu Val  Leu Arg Pro 
    1595                 1600                 1605             


Tyr Ser  Asn Val Ser Asn Leu  Lys Val Trp Asp Phe  Tyr Thr Glu 
    1610                 1615                 1620             


Glu Thr  Leu Ala Glu Gly Pro  Pro Tyr Asp Trp Glu  Leu Ala Gln 
    1625                 1630                 1635             


Gly Pro  Pro Glu Pro Pro Glu  Glu Glu Arg Ser Asp  Gly Gly Ala 
    1640                 1645                 1650             


Pro Gln  Ser Arg Arg Arg Val  Val Trp Pro Cys Tyr  Asp Ser Cys 
    1655                 1660                 1665             


Pro Arg  Ala Gln Pro Asp Ala  Ile Ser Arg Leu Leu  Glu Glu Leu 
    1670                 1675                 1680             


Gln Arg  Leu Glu Thr Glu Leu  Gly Gln Pro Ala Glu  Arg Trp Lys 
    1685                 1690                 1695             


Asp Thr  Trp Asp Arg Val Lys  Ala Ala Gln Arg Leu  Glu Gly Arg 
    1700                 1705                 1710             


Pro Asp  Gly Arg Gly Thr Pro  Ser Ser Leu Leu Val  Ser Thr Ala 
    1715                 1720                 1725             


Pro His  His Arg Arg Ser Leu  Gly Val Tyr Leu Gln  Glu Gly Pro 
    1730                 1735                 1740             


Val Gly  Ser Thr Leu Ser Leu  Ser Leu Asp Ser Asp  Gln Ser Ser 
    1745                 1750                 1755             


Gly Ser  Thr Thr Ser Gly Ser  Arg Gln Ala Ala Arg  Arg Ser Thr 
    1760                 1765                 1770             


Ser Thr  Leu Tyr Ser Gln Phe  Gln Thr Ala Glu Ser  Glu Asn Arg 
    1775                 1780                 1785             


Ser Tyr  Glu Gly Thr Leu Tyr  Lys Lys Gly Ala Phe  Met Lys Pro 
    1790                 1795                 1800             


Trp Lys  Ala Arg Trp Phe Val  Leu Asp Lys Thr Lys  His Gln Leu 
    1805                 1810                 1815             


Arg Tyr  Tyr Asp His Arg Val  Asp Thr Glu Cys Lys  Gly Val Ile 
    1820                 1825                 1830             


Asp Leu  Ala Glu Val Glu Ala  Val Ala Pro Gly Thr  Pro Thr Met 
    1835                 1840                 1845             


Gly Ala  Pro Lys Thr Val Asp  Glu Lys Ala Phe Phe  Asp Val Lys 
    1850                 1855                 1860             


Thr Thr  Arg Arg Val Tyr Asn  Phe Cys Ala Gln Asp  Val Pro Ser 
    1865                 1870                 1875             


Ala Gln  Gln Trp Val Asp Arg  Ile Gln Ser Cys Leu  Ser Asp Ala 
    1880                 1885                 1890             


<210>  326
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Trp Ser Ala Gly Arg Gly Gly Ala Ala Trp Pro Val Leu Leu Gly 
1               5                   10                  15      


Leu Leu Leu Ala Leu Leu Val Pro Gly Gly Gly Ala Ala Lys Thr Gly 
            20                  25                  30          


Ala Glu Leu Val Thr Cys Gly Ser Val Leu Lys Leu Leu Asn Thr His 
        35                  40                  45              


His Arg Val Arg Leu His Ser His Asp Ile Lys Tyr Gly Ser Gly Ser 
    50                  55                  60                  


Gly Gln Gln Ser Val Thr Gly Val Glu Ala Ser Asp Asp Ala Asn Ser 
65                  70                  75                  80  


Tyr Trp Arg Ile Arg Gly Gly Ser Glu Gly Gly Cys Pro Arg Gly Ser 
                85                  90                  95      


Pro Val Arg Cys Gly Gln Ala Val Arg Leu Thr His Val Leu Thr Gly 
            100                 105                 110         


Lys Asn Leu His Thr His His Phe Pro Ser Pro Leu Ser Asn Asn Gln 
        115                 120                 125             


Glu Val Ser Ala Phe Gly Glu Asp Gly Glu Gly Asp Asp Leu Asp Leu 
    130                 135                 140                 


Trp Thr Val Arg Cys Ser Gly Gln His Trp Glu Arg Glu Ala Ala Val 
145                 150                 155                 160 


Arg Phe Gln His Val Gly Thr Ser Val Phe Leu Ser Val Thr Gly Glu 
                165                 170                 175     


Gln Tyr Gly Ser Pro Ile Arg Gly Gln His Glu Val His Gly Met Pro 
            180                 185                 190         


Ser Ala Asn Thr His Asn Thr Trp Lys Ala Met Glu Gly Ile Phe Ile 
        195                 200                 205             


Lys Pro Ser Val Glu Pro Ser Ala Gly His Asp Glu Leu 
    210                 215                 220     


<210>  327
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Ala Ala Leu Leu Leu Arg His Val Gly Arg His Cys Leu Arg Ala 
1               5                   10                  15      


His Phe Ser Pro Gln Leu Cys Ile Arg Asn Ala Val Pro Leu Gly Thr 
            20                  25                  30          


Thr Ala Lys Glu Glu Met Glu Arg Phe Trp Asn Lys Asn Ile Gly Ser 
        35                  40                  45              


Asn Arg Pro Leu Ser Pro His Ile Thr Ile Tyr Ser Trp Ser Leu Pro 
    50                  55                  60                  


Met Ala Met Ser Ile Cys His Arg Gly Thr Gly Ile Ala Leu Ser Ala 
65                  70                  75                  80  


Gly Val Ser Leu Phe Gly Met Ser Ala Leu Leu Leu Pro Gly Asn Phe 
                85                  90                  95      


Glu Ser Tyr Leu Glu Leu Val Lys Ser Leu Cys Leu Gly Pro Ala Leu 
            100                 105                 110         


Ile His Thr Ala Lys Phe Ala Leu Val Phe Pro Leu Met Tyr His Thr 
        115                 120                 125             


Trp Asn Gly Ile Arg His Leu Met Trp Asp Leu Gly Lys Gly Leu Lys 
    130                 135                 140                 


Ile Pro Gln Leu Tyr Gln Ser Gly Val Val Val Leu Val Leu Thr Val 
145                 150                 155                 160 


Leu Ser Ser Met Gly Leu Ala Ala Met 
                165                 


<210>  328
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Leu Gly Lys Gly Gly Lys Arg Lys Phe Asp Glu His Glu Asp Gly 
1               5                   10                  15      


Leu Glu Gly Lys Ile Val Ser Pro Cys Asp Gly Pro Ser Lys Val Ser 
            20                  25                  30          


Tyr Thr Leu Gln Arg Gln Thr Ile Phe Asn Ile Ser Leu Met Lys Leu 
        35                  40                  45              


Tyr Asn His Arg Pro Leu Thr Glu Pro Ser Leu Gln Lys Thr Val Leu 
    50                  55                  60                  


Ile Asn Asn Met Leu Arg Arg Ile Gln Glu Glu Leu Lys Gln Glu Gly 
65                  70                  75                  80  


Ser Leu Arg Pro Met Phe Thr Pro Ser Ser Gln Pro Thr Thr Glu Pro 
                85                  90                  95      


Ser Asp Ser Tyr Arg Glu Ala Pro Pro Ala Phe Ser His Leu Ala Ser 
            100                 105                 110         


Pro Ser Ser His Pro Cys Asp Leu Gly Ser Thr Thr Pro Leu Glu Ala 
        115                 120                 125             


Cys Leu Thr Pro Ala Ser Leu Leu Glu Asp Asp Asp Asp Thr Phe Cys 
    130                 135                 140                 


Thr Ser Gln Ala Met Gln Pro Thr Ala Pro Thr Lys Leu Ser Pro Pro 
145                 150                 155                 160 


Ala Leu Leu Pro Glu Lys Asp Ser Phe Ser Ser Ala Leu Asp Glu Ile 
                165                 170                 175     


Glu Glu Leu Cys Pro Thr Ser Thr Ser Thr Glu Ala Ala Thr Ala Ala 
            180                 185                 190         


Thr Asp Ser Val Lys Gly Thr Ser Ser Glu Ala Gly Thr Gln Lys Leu 
        195                 200                 205             


Asp Gly Pro Gln Glu Ser Arg Ala Asp Asp Ser Lys Leu Met Asp Ser 
    210                 215                 220                 


Leu Pro Gly Asn Phe Glu Ile Thr Thr Ser Thr Gly Phe Leu Thr Asp 
225                 230                 235                 240 


Leu Thr Leu Asp Asp Ile Leu Phe Ala Asp Ile Asp Thr Ser Met Tyr 
                245                 250                 255     


Asp Phe Asp Pro Cys Thr Ser Ser Ser Gly Thr Ala Ser Lys Met Ala 
            260                 265                 270         


Pro Val Ser Ala Asp Asp Leu Leu Lys Thr Leu Ala Pro Tyr Ser Ser 
        275                 280                 285             


Gln Pro Val Thr Pro Ser Gln Pro Phe Lys Met Asp Leu Thr Glu Leu 
    290                 295                 300                 


Asp His Ile Met Glu Val Leu Val Gly Ser 
305                 310                 


<210>  329
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Val Ile Arg Val Tyr Ile Ala Ser Ser Ser Gly Ser Thr Ala Ile 
1               5                   10                  15      


Lys Lys Lys Gln Gln Asp Val Leu Gly Phe Leu Glu Ala Asn Lys Ile 
            20                  25                  30          


Gly Phe Glu Glu Lys Asp Ile Ala Ala Asn Glu Glu Asn Arg Lys Trp 
        35                  40                  45              


Met Arg Glu Asn Val Pro Glu Asn Ser Arg Pro Ala Thr Gly Tyr Pro 
    50                  55                  60                  


Leu Pro Pro Gln Ile Phe Asn Glu Ser Gln Tyr Arg Gly Asp Tyr Asp 
65                  70                  75                  80  


Ala Phe Phe Glu Ala Arg Glu Asn Asn Ala Val Tyr Ala Phe Leu Gly 
                85                  90                  95      


Leu Thr Ala Pro Pro Gly Ser Lys Glu Ala Glu Val Gln Ala Lys Gln 
            100                 105                 110         


Gln Ala 
        


<210>  330
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Asp Phe Asn Met Lys Lys Leu Ala Ser Asp Ala Gly Ile Phe Phe 
1               5                   10                  15      


Thr Arg Ala Val Gln Phe Thr Glu Glu Lys Phe Gly Gln Ala Glu Lys 
            20                  25                  30          


Thr Glu Leu Asp Ala His Phe Glu Asn Leu Leu Ala Arg Ala Asp Ser 
        35                  40                  45              


Thr Lys Asn Trp Thr Glu Lys Ile Leu Arg Gln Thr Glu Val Leu Leu 
    50                  55                  60                  


Gln Pro Asn Pro Ser Ala Arg Val Glu Glu Phe Leu Tyr Glu Lys Leu 
65                  70                  75                  80  


Asp Arg Lys Val Pro Ser Arg Val Thr Asn Gly Glu Leu Leu Ala Gln 
                85                  90                  95      


Tyr Met Ala Asp Ala Ala Ser Glu Leu Gly Pro Thr Thr Pro Tyr Gly 
            100                 105                 110         


Lys Thr Leu Ile Lys Val Ala Glu Ala Glu Lys Gln Leu Gly Ala Ala 
        115                 120                 125             


Glu Arg Asp Phe Ile His Thr Ala Ser Ile Ser Phe Leu Thr Pro Leu 
    130                 135                 140                 


Arg Asn Phe Leu Glu Gly Asp Trp Lys Thr Ile Ser Lys Glu Arg Arg 
145                 150                 155                 160 


Leu Leu Gln Asn Arg Arg Leu Asp Leu Asp Ala Cys Lys Ala Arg Leu 
                165                 170                 175     


Lys Lys Ala Lys Ala Ala Glu Ala Lys Ala Thr Thr Val Pro Asp Phe 
            180                 185                 190         


Gln Glu Thr Arg Pro Arg Asn Tyr Ile Leu Ser Ala Ser Ala Ser Ala 
        195                 200                 205             


Leu Trp Asn Asp Glu Val Asp Lys Ala Glu Gln Glu Leu Arg Val Ala 
    210                 215                 220                 


Gln Thr Glu Phe Asp Arg Gln Ala Glu Val Thr Arg Leu Leu Leu Glu 
225                 230                 235                 240 


Gly Ile Ser Ser Thr His Val Asn His Leu Arg Cys Leu His Glu Phe 
                245                 250                 255     


Val Lys Ser Gln Thr Thr Tyr Tyr Ala Gln Cys Tyr Arg His Met Leu 
            260                 265                 270         


Asp Leu Gln Lys Gln Leu Gly Arg Phe Pro Gly Thr Phe Val Gly Thr 
        275                 280                 285             


Thr Glu Pro Ala Ser Pro Pro Leu Ser Ser Thr Ser Pro Thr Thr Ala 
    290                 295                 300                 


Ala Ala Thr Met Pro Val Val Pro Ser Val Ala Ser Leu Ala Pro Pro 
305                 310                 315                 320 


Gly Glu Ala Ser Leu Cys Leu Glu Glu Val Ala Pro Pro Ala Ser Gly 
                325                 330                 335     


Thr Arg Lys Ala Arg Val Leu Tyr Asp Tyr Glu Ala Ala Asp Ser Ser 
            340                 345                 350         


Glu Leu Ala Leu Leu Ala Asp Glu Leu Ile Thr Val Tyr Ser Leu Pro 
        355                 360                 365             


Gly Met Asp Pro Asp Trp Leu Ile Gly Glu Arg Gly Asn Lys Lys Gly 
    370                 375                 380                 


Lys Val Pro Val Thr Tyr Leu Glu Leu Leu Ser 
385                 390                 395 


<210>  331
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  332
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Val Leu Gly Pro Glu Gln Lys Met Ser Asp Asp Ser Val Ser Gly 
1               5                   10                  15      


Asp His Gly Glu Ser Ala Ser Leu Gly Asn Ile Asn Pro Ala Tyr Ser 
            20                  25                  30          


Asn Pro Ser Leu Ser Gln Ser Pro Gly Asp Ser Glu Glu Tyr Phe Ala 
        35                  40                  45              


Thr Tyr Phe Asn Glu Lys Ile Ser Ile Pro Glu Glu Glu Tyr Ser Cys 
    50                  55                  60                  


Phe Ser Phe Arg Lys Leu Trp Ala Phe Thr Gly Pro Gly Phe Leu Met 
65                  70                  75                  80  


Ser Ile Ala Tyr Leu Asp Pro Gly Asn Ile Glu Ser Asp Leu Gln Ser 
                85                  90                  95      


Gly Ala Val Ala Gly Phe Lys Leu Leu Trp Ile Leu Leu Leu Ala Thr 
            100                 105                 110         


Leu Val Gly Leu Leu Leu Gln Arg Leu Ala Ala Arg Leu Gly Val Val 
        115                 120                 125             


Thr Gly Leu His Leu Ala Glu Val Cys His Arg Gln Tyr Pro Lys Val 
    130                 135                 140                 


Pro Arg Val Ile Leu Trp Leu Met Val Glu Leu Ala Ile Ile Gly Ser 
145                 150                 155                 160 


Asp Met Gln Glu Val Ile Gly Ser Ala Ile Ala Ile Asn Leu Leu Ser 
                165                 170                 175     


Val Gly Arg Ile Pro Leu Trp Gly Gly Val Leu Ile Thr Ile Ala Asp 
            180                 185                 190         


Thr Phe Val Phe Leu Phe Leu Asp Lys Tyr Gly Leu Arg Lys Leu Glu 
        195                 200                 205             


Ala Phe Phe Gly Phe Leu Ile Thr Ile Met Ala Leu Thr Phe Gly Tyr 
    210                 215                 220                 


Glu Tyr Val Thr Val Lys Pro Ser Gln Ser Gln Val Leu Lys Gly Met 
225                 230                 235                 240 


Phe Val Pro Ser Cys Ser Gly Cys Arg Thr Pro Gln Ile Glu Gln Ala 
                245                 250                 255     


Val Gly Ile Val Gly Ala Val Ile Met Pro His Asn Met Tyr Leu His 
            260                 265                 270         


Ser Ala Leu Val Lys Ser Arg Gln Val Asn Arg Asn Asn Lys Gln Glu 
        275                 280                 285             


Val Arg Glu Ala Asn Lys Tyr Phe Phe Ile Glu Ser Cys Ile Ala Leu 
    290                 295                 300                 


Phe Val Ser Phe Ile Ile Asn Val Phe Val Val Ser Val Phe Ala Glu 
305                 310                 315                 320 


Ala Phe Phe Gly Lys Thr Asn Glu Gln Val Val Glu Val Cys Thr Asn 
                325                 330                 335     


Thr Ser Ser Pro His Ala Gly Leu Phe Pro Lys Asp Asn Ser Thr Leu 
            340                 345                 350         


Ala Val Asp Ile Tyr Lys Gly Gly Val Val Leu Gly Cys Tyr Phe Gly 
        355                 360                 365             


Pro Ala Ala Leu Tyr Ile Trp Ala Val Gly Ile Leu Ala Ala Gly Gln 
    370                 375                 380                 


Ser Ser Thr Met Thr Gly Thr Tyr Ser Gly Gln Phe Val Met Glu Gly 
385                 390                 395                 400 


Phe Leu Asn Leu Lys Trp Ser Arg Phe Ala Arg Val Val Leu Thr Arg 
                405                 410                 415     


Ser Ile Ala Ile Ile Pro Thr Leu Leu Val Ala Val Phe Gln Asp Val 
            420                 425                 430         


Glu His Leu Thr Gly Met Asn Asp Phe Leu Asn Val Leu Gln Ser Leu 
        435                 440                 445             


Gln Leu Pro Phe Ala Leu Ile Pro Ile Leu Thr Phe Thr Ser Leu Arg 
    450                 455                 460                 


Pro Val Met Ser Asp Phe Ala Asn Gly Leu Gly Trp Arg Ile Ala Gly 
465                 470                 475                 480 


Gly Ile Leu Val Leu Ile Ile Cys Ser Ile Asn Met Tyr Phe Val Val 
                485                 490                 495     


Val Tyr Val Arg Asp Leu Gly His Val Ala Leu Tyr Val Val Ala Ala 
            500                 505                 510         


Val Val Ser Val Ala Tyr Leu Gly Phe Val Phe Tyr Leu Gly Trp Gln 
        515                 520                 525             


Cys Leu Ile Ala Leu Gly Met Ser Phe Leu Asp Cys Gly His Thr Val 
    530                 535                 540                 


Ser Ile Ser Lys Gly Leu Leu Thr Glu Glu Ala Thr Arg Gly Tyr Val 
545                 550                 555                 560 


Lys 
    


<210>  333
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Ala Ser Glu Ser Ser Pro Leu Leu Ala Tyr Arg Leu Leu Gly Glu 
1               5                   10                  15      


Glu Gly Val Ala Leu Pro Ala Asn Gly Ala Gly Gly Pro Gly Gly Ala 
            20                  25                  30          


Ser Ala Arg Lys Leu Ser Thr Phe Leu Gly Val Val Val Pro Thr Val 
        35                  40                  45              


Leu Ser Met Phe Ser Ile Val Val Phe Leu Arg Ile Gly Phe Val Val 
    50                  55                  60                  


Gly His Ala Gly Leu Leu Gln Ala Leu Ala Met Leu Leu Val Ala Tyr 
65                  70                  75                  80  


Phe Ile Leu Ala Leu Thr Val Leu Ser Val Cys Ala Ile Ala Thr Asn 
                85                  90                  95      


Gly Ala Val Gln Gly Gly Gly Ala Tyr Phe Met Ile Ser Arg Thr Leu 
            100                 105                 110         


Gly Pro Glu Val Gly Gly Ser Ile Gly Leu Met Phe Tyr Leu Ala Asn 
        115                 120                 125             


Val Cys Gly Cys Ala Val Ser Leu Leu Gly Leu Val Glu Ser Val Leu 
    130                 135                 140                 


Asp Val Phe Gly Ala Asp Ala Thr Gly Pro Ser Gly Leu Arg Val Leu 
145                 150                 155                 160 


Pro Gln Gly Tyr Gly Trp Asn Leu Leu Tyr Gly Ser Leu Leu Leu Gly 
                165                 170                 175     


Leu Val Gly Gly Val Cys Thr Leu Gly Ala Gly Leu Tyr Ala Arg Ala 
            180                 185                 190         


Ser Phe Leu Thr Phe Leu Leu Val Ser Gly Ser Leu Ala Ser Val Leu 
        195                 200                 205             


Ile Ser Phe Val Ala Val Gly Pro Arg Asp Ile Arg Leu Thr Pro Arg 
    210                 215                 220                 


Pro Gly Pro Asn Gly Ser Ser Leu Pro Pro Arg Phe Gly His Phe Thr 
225                 230                 235                 240 


Gly Phe Asn Ser Ser Thr Leu Lys Asp Asn Leu Gly Ala Gly Tyr Ala 
                245                 250                 255     


Glu Asp Tyr Thr Thr Gly Ala Val Met Asn Phe Ala Ser Val Phe Ala 
            260                 265                 270         


Val Leu Phe Asn Gly Cys Thr Gly Ile Met Ala Gly Ala Asn Met Ser 
        275                 280                 285             


Gly Glu Leu Lys Asp Pro Ser Arg Ala Ile Pro Leu Gly Thr Ile Val 
    290                 295                 300                 


Ala Val Ala Tyr Thr Phe Phe Val Tyr Val Leu Leu Phe Phe Leu Ser 
305                 310                 315                 320 


Ser Phe Thr Cys Asp Arg Thr Leu Leu Gln Glu Asp Tyr Gly Phe Phe 
                325                 330                 335     


Arg Ala Ile Ser Leu Trp Pro Pro Leu Val Leu Ile Gly Ile Tyr Ala 
            340                 345                 350         


Thr Ala Leu Ser Ala Ser Met Ser Ser Leu Ile Gly Ala Ser Arg Ile 
        355                 360                 365             


Leu His Ala Leu Ala Arg Asp Asp Leu Phe Gly Val Ile Leu Ala Pro 
    370                 375                 380                 


Ala Lys Val Val Ser Arg Gly Gly Asn Pro Trp Ala Ala Val Leu Tyr 
385                 390                 395                 400 


Ser Trp Gly Leu Val Gln Leu Val Leu Leu Ala Gly Lys Leu Asn Thr 
                405                 410                 415     


Leu Ala Ala Val Val Thr Val Phe Tyr Leu Val Ala Tyr Ala Ala Val 
            420                 425                 430         


Asp Leu Ser Cys Leu Ser Leu Glu Trp Ala Ser Ala Pro Asn Phe Arg 
        435                 440                 445             


Pro Thr Phe Ser Leu Phe Ser Trp His Thr Cys Leu Leu Gly Val Ala 
    450                 455                 460                 


Ser Cys Leu Leu Met Met Phe Leu Ile Ser Pro Gly Ala Ala Gly Gly 
465                 470                 475                 480 


Ser Leu Leu Leu Met Gly Leu Leu Ala Ala Leu Leu Thr Ala Arg Gly 
                485                 490                 495     


Gly Pro Ser Ser Trp Gly Tyr Val Ser Gln Ala Leu Leu Phe His Gln 
            500                 505                 510         


Val Arg Lys Tyr Leu Leu Arg Leu Asp Val Arg Lys Asp His Val Lys 
        515                 520                 525             


Phe Trp Arg Pro Gln Leu Leu Leu Leu Val Gly Asn Pro Arg Gly Ala 
    530                 535                 540                 


Leu Pro Leu Leu Arg Leu Ala Asn Gln Leu Lys Lys Gly Gly Leu Tyr 
545                 550                 555                 560 


Val Leu Gly His Val Thr Leu Gly Asp Leu Asp Ser Leu Pro Ser Asp 
                565                 570                 575     


Pro Val Gln Pro Gln Tyr Gly Ala Trp Leu Ser Leu Val Asp Arg Ala 
            580                 585                 590         


Gln Val Lys Ala Phe Val Asp Leu Thr Leu Ser Pro Ser Val Arg Gln 
        595                 600                 605             


Gly Ala Gln His Leu Leu Arg Ile Ser Gly Leu Gly Gly Met Lys Pro 
    610                 615                 620                 


Asn Thr Leu Val Leu Gly Phe Tyr Asp Asp Ala Pro Pro Gln Asp His 
625                 630                 635                 640 


Phe Leu Thr Asp Pro Ala Phe Ser Glu Pro Ala Asp Ser Thr Arg Glu 
                645                 650                 655     


Gly Ser Ser Pro Ala Leu Ser Thr Leu Phe Pro Pro Pro Arg Ala Pro 
            660                 665                 670         


Gly Ser Pro Arg Ala Leu Asn Pro Gln Asp Tyr Val Ala Thr Val Ala 
        675                 680                 685             


Asp Ala Leu Lys Met Asn Lys Asn Val Val Leu Ala Arg Ala Ser Gly 
    690                 695                 700                 


Ala Leu Pro Pro Glu Arg Leu Ser Arg Gly Ser Gly Gly Thr Ser Gln 
705                 710                 715                 720 


Leu His His Val Asp Val Trp Pro Leu Asn Leu Leu Arg Pro Arg Gly 
                725                 730                 735     


Gly Pro Gly Tyr Val Asp Val Cys Gly Leu Phe Leu Leu Gln Met Ala 
            740                 745                 750         


Thr Ile Leu Gly Met Val Pro Ala Trp His Ser Ala Arg Leu Arg Ile 
        755                 760                 765             


Phe Leu Cys Leu Gly Pro Arg Glu Ala Pro Gly Ala Ala Glu Gly Arg 
    770                 775                 780                 


Leu Arg Ala Leu Leu Ser Gln Leu Arg Ile Arg Ala Glu Val Gln Glu 
785                 790                 795                 800 


Val Val Trp Gly Glu Gly Ala Gly Ala Gly Glu Pro Glu Ala Glu Glu 
                805                 810                 815     


Glu Gly Asp Phe Val Asn Ser Gly Arg Gly Asp Ala Glu Ala Glu Ala 
            820                 825                 830         


Leu Ala Arg Ser Ala Asn Ala Leu Val Arg Ala Gln Gln Gly Arg Gly 
        835                 840                 845             


Thr Gly Gly Gly Pro Gly Gly Pro Glu Gly Gly Asp Ala Glu Gly Pro 
    850                 855                 860                 


Ile Thr Ala Leu Thr Phe Leu Tyr Leu Pro Arg Pro Pro Ala Asp Pro 
865                 870                 875                 880 


Ala Arg Tyr Pro Arg Tyr Leu Ala Leu Leu Glu Thr Leu Thr Arg Asp 
                885                 890                 895     


Leu Gly Pro Thr Leu Leu Val His Gly Val Thr Pro Val Thr Cys Thr 
            900                 905                 910         


Asp Leu 
        


<210>  334
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Glu Leu Arg Ser Gly Ser Val Gly Ser Gln Ala Val Ala Arg Arg 
1               5                   10                  15      


Met Asp Gly Asp Ser Arg Asp Gly Gly Gly Gly Lys Asp Ala Thr Gly 
            20                  25                  30          


Ser Glu Asp Tyr Glu Asn Leu Pro Thr Ser Ala Ser Val Ser Thr His 
        35                  40                  45              


Met Thr Ala Gly Ala Met Ala Gly Ile Leu Glu His Ser Val Met Tyr 
    50                  55                  60                  


Pro Val Asp Ser Val Lys Thr Arg Met Gln Ser Leu Ser Pro Asp Pro 
65                  70                  75                  80  


Lys Ala Gln Tyr Thr Ser Ile Tyr Gly Ala Leu Lys Lys Ile Met Arg 
                85                  90                  95      


Thr Glu Gly Phe Trp Arg Pro Leu Arg Gly Val Asn Val Met Ile Met 
            100                 105                 110         


Gly Ala Gly Pro Ala His Ala Met Tyr Phe Ala Cys Tyr Glu Asn Met 
        115                 120                 125             


Lys Arg Thr Leu Asn Asp Val Phe His His Gln Gly Asn Ser His Leu 
    130                 135                 140                 


Ala Asn Gly Ile Ala Gly Ser Met Ala Thr Leu Leu His Asp Ala Val 
145                 150                 155                 160 


Met Asn Pro Ala Glu Val Val Lys Gln Arg Leu Gln Met Tyr Asn Ser 
                165                 170                 175     


Gln His Arg Ser Ala Ile Ser Cys Ile Arg Thr Val Trp Arg Thr Glu 
            180                 185                 190         


Gly Leu Gly Ala Phe Tyr Arg Ser Tyr Thr Thr Gln Leu Thr Met Asn 
        195                 200                 205             


Ile Pro Phe Gln Ser Ile His Phe Ile Thr Tyr Glu Phe Leu Gln Glu 
    210                 215                 220                 


Gln Val Asn Pro His Arg Thr Tyr Asn Pro Gln Ser His Ile Ile Ser 
225                 230                 235                 240 


Gly Gly Leu Ala Gly Ala Leu Ala Ala Ala Ala Thr Thr Pro Leu Asp 
                245                 250                 255     


Val Cys Lys Thr Leu Leu Asn Thr Gln Glu Asn Val Ala Leu Ser Leu 
            260                 265                 270         


Ala Asn Ile Ser Gly Arg Leu Ser Gly Met Ala Asn Ala Phe Arg Thr 
        275                 280                 285             


Val Tyr Gln Leu Asn Gly Leu Ala Gly Tyr Phe Lys Gly Ile Gln Ala 
    290                 295                 300                 


Arg Val Ile Tyr Gln Met Pro Ser Thr Ala Ile Ser Trp Ser Val Tyr 
305                 310                 315                 320 


Glu Phe Phe Lys Tyr Phe Leu Thr Lys Arg Gln Leu Glu Asn Arg Ala 
                325                 330                 335     


Pro Tyr 
        


<210>  335
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Gly Thr Gln Lys Val Thr Pro Ala Leu Ile Phe Ala Ile Thr Val 
1               5                   10                  15      


Ala Thr Ile Gly Ser Phe Gln Phe Gly Tyr Asn Thr Gly Val Ile Asn 
            20                  25                  30          


Ala Pro Glu Lys Ile Ile Lys Glu Phe Ile Asn Lys Thr Leu Thr Asp 
        35                  40                  45              


Lys Gly Asn Ala Pro Pro Ser Glu Val Leu Leu Thr Ser Leu Trp Ser 
    50                  55                  60                  


Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser Phe Ser 
65                  70                  75                  80  


Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met Leu Ile 
                85                  90                  95      


Val Asn Leu Leu Ala Val Thr Gly Gly Cys Phe Met Gly Leu Cys Lys 
            100                 105                 110         


Val Ala Lys Ser Val Glu Met Leu Ile Leu Gly Arg Leu Val Ile Gly 
        115                 120                 125             


Leu Phe Cys Gly Leu Cys Thr Gly Phe Val Pro Met Tyr Ile Gly Glu 
    130                 135                 140                 


Ile Ser Pro Thr Ala Leu Arg Gly Ala Phe Gly Thr Leu Asn Gln Leu 
145                 150                 155                 160 


Gly Ile Val Val Gly Ile Leu Val Ala Gln Ile Phe Gly Leu Glu Phe 
                165                 170                 175     


Ile Leu Gly Ser Glu Glu Leu Trp Pro Leu Leu Leu Gly Phe Thr Ile 
            180                 185                 190         


Leu Pro Ala Ile Leu Gln Ser Ala Ala Leu Pro Phe Cys Pro Glu Ser 
        195                 200                 205             


Pro Arg Phe Leu Leu Ile Asn Arg Lys Glu Glu Glu Asn Ala Lys Gln 
    210                 215                 220                 


Ile Leu Gln Arg Leu Trp Gly Thr Gln Asp Val Ser Gln Asp Ile Gln 
225                 230                 235                 240 


Glu Met Lys Asp Glu Ser Ala Arg Met Ser Gln Glu Lys Gln Val Thr 
                245                 250                 255     


Val Leu Glu Leu Phe Arg Val Ser Ser Tyr Arg Gln Pro Ile Ile Ile 
            260                 265                 270         


Ser Ile Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn Ala Val 
        275                 280                 285             


Phe Tyr Tyr Ser Thr Gly Ile Phe Lys Asp Ala Gly Val Gln Glu Pro 
    290                 295                 300                 


Ile Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Ile Phe Thr Val 
305                 310                 315                 320 


Val Ser Leu Phe Leu Val Glu Arg Ala Gly Arg Arg Thr Leu His Met 
                325                 330                 335     


Ile Gly Leu Gly Gly Met Ala Phe Cys Ser Thr Leu Met Thr Val Ser 
            340                 345                 350         


Leu Leu Leu Lys Asp Asn Tyr Asn Gly Met Ser Phe Val Cys Ile Gly 
        355                 360                 365             


Ala Ile Leu Val Phe Val Ala Phe Phe Glu Ile Gly Pro Gly Pro Ile 
    370                 375                 380                 


Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg Pro Ala 
385                 390                 395                 400 


Ala Met Ala Val Ala Gly Cys Ser Asn Trp Thr Ser Asn Phe Leu Val 
                405                 410                 415     


Gly Leu Leu Phe Pro Ser Ala Ala His Tyr Leu Gly Ala Tyr Val Phe 
            420                 425                 430         


Ile Ile Phe Thr Gly Phe Leu Ile Thr Phe Leu Ala Phe Thr Phe Phe 
        435                 440                 445             


Lys Val Pro Glu Thr Arg Gly Arg Thr Phe Glu Asp Ile Thr Arg Ala 
    450                 455                 460                 


Phe Glu Gly Gln Ala His Gly Ala Asp Arg Ser Gly Lys Asp Gly Val 
465                 470                 475                 480 


Met Glu Met Asn Ser Ile Glu Pro Ala Lys Glu Thr Thr Thr Asn Val 
                485                 490                 495     


<210>  336
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Ala Pro Gly Arg Ala Val Ala Gly Leu Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Gly Leu Gly Gly Val Ala Glu Gly Pro Gly Leu Ala Phe Ser Glu Asp 
            20                  25                  30          


Val Leu Ser Val Phe Gly Ala Asn Leu Ser Leu Ser Ala Ala Gln Leu 
        35                  40                  45              


Gln His Leu Leu Glu Gln Met Gly Ala Ala Ser Arg Val Gly Val Pro 
    50                  55                  60                  


Glu Pro Gly Gln Leu His Phe Asn Gln Cys Leu Thr Ala Glu Glu Ile 
65                  70                  75                  80  


Phe Ser Leu His Gly Phe Ser Asn Ala Thr Gln Ile Thr Ser Ser Lys 
                85                  90                  95      


Phe Ser Val Ile Cys Pro Ala Val Leu Gln Gln Leu Asn Phe His Pro 
            100                 105                 110         


Cys Glu Asp Arg Pro Lys His Lys Thr Arg Pro Ser His Ser Glu Val 
        115                 120                 125             


Trp Gly Tyr Gly Phe Leu Ser Val Thr Ile Ile Asn Leu Ala Ser Leu 
    130                 135                 140                 


Leu Gly Leu Ile Leu Thr Pro Leu Ile Lys Lys Ser Tyr Phe Pro Lys 
145                 150                 155                 160 


Ile Leu Thr Phe Phe Val Gly Leu Ala Ile Gly Thr Leu Phe Ser Asn 
                165                 170                 175     


Ala Ile Phe Gln Leu Ile Pro Glu Ala Phe Gly Phe Asp Pro Lys Val 
            180                 185                 190         


Asp Ser Tyr Val Glu Lys Ala Val Ala Val Phe Gly Gly Phe Tyr Leu 
        195                 200                 205             


Leu Phe Phe Phe Glu Arg Met Leu Lys Met Leu Leu Lys Thr Tyr Gly 
    210                 215                 220                 


Gln Asn Gly His Thr His Phe Gly Asn Asp Asn Phe Gly Pro Gln Glu 
225                 230                 235                 240 


Lys Thr His Gln Pro Lys Ala Leu Pro Ala Ile Asn Gly Val Thr Cys 
                245                 250                 255     


Tyr Ala Asn Pro Ala Val Thr Glu Ala Asn Gly His Ile His Phe Asp 
            260                 265                 270         


Asn Val Ser Val Val Ser Leu Gln Asp Gly Lys Lys Glu Pro Ser Ser 
        275                 280                 285             


Cys Thr Cys Leu Lys Gly Pro Lys Leu Ser Glu Ile Gly Thr Ile Ala 
    290                 295                 300                 


Trp Met Ile Thr Leu Cys Asp Ala Leu His Asn Phe Ile Asp Gly Leu 
305                 310                 315                 320 


Ala Ile Gly Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly Leu Ser Thr 
                325                 330                 335     


Ser Ile Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu Gly Asp Phe 
            340                 345                 350         


Val Ile Leu Leu Asn Ala Gly Met Ser Thr Arg Gln Ala Leu Leu Phe 
        355                 360                 365             


Asn Phe Leu Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala Phe Gly Ile 
    370                 375                 380                 


Leu Val Gly Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala Leu Ala Gly 
385                 390                 395                 400 


Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro Glu Met Asn 
                405                 410                 415     


Asp Met Leu Arg Glu Lys Val Thr Gly Arg Lys Thr Asp Phe Thr Phe 
            420                 425                 430         


Phe Met Ile Gln Asn Ala Gly Met Leu Thr Gly Phe Thr Ala Ile Leu 
        435                 440                 445             


Leu Ile Thr Leu Tyr Ala Gly Glu Ile Glu Leu Glu 
    450                 455                 460 


<210>  337
<211>  358
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Ser Ala Asp Ala Ala Ala Gly Ala Pro Leu Pro Arg Leu Cys Cys 
1               5                   10                  15      


Leu Glu Lys Gly Pro Asn Gly Tyr Gly Phe His Leu His Gly Glu Lys 
            20                  25                  30          


Gly Lys Leu Gly Gln Tyr Ile Arg Leu Val Glu Pro Gly Ser Pro Ala 
        35                  40                  45              


Glu Lys Ala Gly Leu Leu Ala Gly Asp Arg Leu Val Glu Val Asn Gly 
    50                  55                  60                  


Glu Asn Val Glu Lys Glu Thr His Gln Gln Val Val Ser Arg Ile Arg 
65                  70                  75                  80  


Ala Ala Leu Asn Ala Val Arg Leu Leu Val Val Asp Pro Glu Thr Asp 
                85                  90                  95      


Glu Gln Leu Gln Lys Leu Gly Val Gln Val Arg Glu Glu Leu Leu Arg 
            100                 105                 110         


Ala Gln Glu Ala Pro Gly Gln Ala Glu Pro Pro Ala Ala Ala Glu Val 
        115                 120                 125             


Gln Gly Ala Gly Asn Glu Asn Glu Pro Arg Glu Ala Asp Lys Ser His 
    130                 135                 140                 


Pro Glu Gln Arg Glu Leu Arg Pro Arg Leu Cys Thr Met Lys Lys Gly 
145                 150                 155                 160 


Pro Ser Gly Tyr Gly Phe Asn Leu His Ser Asp Lys Ser Lys Pro Gly 
                165                 170                 175     


Gln Phe Ile Arg Ser Val Asp Pro Asp Ser Pro Ala Glu Ala Ser Gly 
            180                 185                 190         


Leu Arg Ala Gln Asp Arg Ile Val Glu Val Asn Gly Val Cys Met Glu 
        195                 200                 205             


Gly Lys Gln His Gly Asp Val Val Ser Ala Ile Arg Ala Gly Gly Asp 
    210                 215                 220                 


Glu Thr Lys Leu Leu Val Val Asp Arg Glu Thr Asp Glu Phe Phe Lys 
225                 230                 235                 240 


Lys Cys Arg Val Ile Pro Ser Gln Glu His Leu Asn Gly Pro Leu Pro 
                245                 250                 255     


Val Pro Phe Thr Asn Gly Glu Ile Gln Lys Glu Asn Ser Arg Glu Ala 
            260                 265                 270         


Leu Ala Glu Ala Ala Leu Glu Ser Pro Arg Pro Ala Leu Val Arg Ser 
        275                 280                 285             


Ala Ser Ser Asp Thr Ser Glu Glu Leu Asn Ser Gln Asp Ser Pro Pro 
    290                 295                 300                 


Lys Gln Asp Ser Thr Ala Pro Ser Ser Thr Ser Ser Ser Asp Pro Ile 
305                 310                 315                 320 


Leu Asp Phe Asn Ile Ser Leu Ala Met Ala Lys Glu Arg Ala His Gln 
                325                 330                 335     


Lys Arg Ser Ser Lys Arg Ala Pro Gln Met Asp Trp Ser Lys Lys Asn 
            340                 345                 350         


Glu Leu Phe Ser Asn Leu 
        355             


<210>  338
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Gly Thr Pro Pro Gly Leu Gln Thr Asp Cys Glu Ala Leu Leu Ser 
1               5                   10                  15      


Arg Phe Gln Glu Thr Asp Ser Val Arg Phe Glu Asp Phe Thr Glu Leu 
            20                  25                  30          


Trp Arg Asn Met Lys Phe Gly Thr Ile Phe Cys Gly Arg Met Arg Asn 
        35                  40                  45              


Leu Glu Lys Asn Met Phe Thr Lys Glu Ala Leu Ala Leu Ala Trp Arg 
    50                  55                  60                  


Tyr Phe Leu Pro Pro Tyr Thr Phe Gln Ile Arg Val Gly Ala Leu Tyr 
65                  70                  75                  80  


Leu Leu Tyr Gly Leu Tyr Asn Thr Gln Leu Cys Gln Pro Lys Gln Lys 
                85                  90                  95      


Ile Arg Val Ala Leu Lys Asp Trp Asp Glu Val Leu Lys Phe Gln Gln 
            100                 105                 110         


Asp Leu Val Asn Ala Gln His Phe Asp Ala Ala Tyr Ile Phe Arg Lys 
        115                 120                 125             


Leu Arg Leu Asp Arg Ala Phe His Phe Thr Ala Met Pro Lys Leu Leu 
    130                 135                 140                 


Ser Tyr Arg Met Lys Lys Lys Ile His Arg Ala Glu Val Thr Glu Glu 
145                 150                 155                 160 


Phe Lys Asp Pro Ser Asp Arg Val Met Lys Leu Ile Thr Ser Asp Val 
                165                 170                 175     


Leu Glu Glu Met Leu Asn Val His Asp His Tyr Gln Asn Met Lys His 
            180                 185                 190         


Val Ile Ser Val Asp Lys Ser Lys Pro Asp Lys Ala Leu Ser Leu Ile 
        195                 200                 205             


Lys Asp Asp Phe Phe Asp Asn Ile Lys Asn Ile Val Leu Glu His Gln 
    210                 215                 220                 


Gln Trp His Lys Asp Arg Lys Asn Pro Ser Leu Lys Ser Lys Thr Asn 
225                 230                 235                 240 


Asp Gly Glu Glu Lys Met Glu Gly Asn Ser Gln Glu Thr Glu Arg Cys 
                245                 250                 255     


Glu Arg Ala Glu Ser Leu Ala Lys Ile Lys Ser Lys Ala Phe Ser Val 
            260                 265                 270         


Val Ile Gln Ala Ser Lys Ser Arg Arg His Arg Gln Val Lys Leu Asp 
        275                 280                 285             


Ser Ser Asp Ser Asp Ser Ala Ser Gly Gln Gly Gln Val Lys Ala Thr 
    290                 295                 300                 


Arg Lys Lys Glu Lys Lys Glu Arg Leu Lys Pro Ala Gly Arg Lys Met 
305                 310                 315                 320 


Ser Leu Arg Asn Lys Gly Asn Val Gln Asn Ile His Lys Glu Asp Lys 
                325                 330                 335     


Pro Leu Ser Leu Ser Met Pro Val Ile Thr Glu Glu Glu Glu Asn Glu 
            340                 345                 350         


Ser Leu Ser Gly Thr Glu Phe Thr Ala Ser Lys Lys Arg Arg Lys His 
        355                 360                 365             


<210>  339
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Glu Arg Pro Trp Gly Ala Ala Asp Gly Leu Ser Arg Trp Pro His 
1               5                   10                  15      


Gly Leu Gly Leu Leu Leu Leu Leu Gln Leu Leu Pro Pro Ser Thr Leu 
            20                  25                  30          


Ser Gln Asp Arg Leu Asp Ala Pro Pro Pro Pro Ala Ala Pro Leu Pro 
        35                  40                  45              


Arg Trp Ser Gly Pro Ile Gly Val Ser Trp Gly Leu Arg Ala Ala Ala 
    50                  55                  60                  


Ala Gly Gly Ala Phe Pro Arg Gly Gly Arg Trp Arg Arg Ser Ala Pro 
65                  70                  75                  80  


Gly Glu Asp Glu Glu Cys Gly Arg Val Arg Asp Phe Val Ala Lys Leu 
                85                  90                  95      


Ala Asn Asn Thr His Gln His Val Phe Asp Asp Leu Arg Gly Ser Val 
            100                 105                 110         


Ser Leu Ser Trp Val Gly Asp Ser Thr Gly Val Ile Leu Val Leu Thr 
        115                 120                 125             


Thr Phe His Val Pro Leu Val Ile Met Thr Phe Gly Gln Ser Lys Leu 
    130                 135                 140                 


Tyr Arg Ser Glu Asp Tyr Gly Lys Asn Phe Lys Asp Ile Thr Asp Leu 
145                 150                 155                 160 


Ile Asn Asn Thr Phe Ile Arg Thr Glu Phe Gly Met Ala Ile Gly Pro 
                165                 170                 175     


Glu Asn Ser Gly Lys Val Val Leu Thr Ala Glu Val Ser Gly Gly Ser 
            180                 185                 190         


Arg Gly Gly Arg Ile Phe Arg Ser Ser Asp Phe Ala Lys Asn Phe Val 
        195                 200                 205             


Gln Thr Asp Leu Pro Phe His Pro Leu Thr Gln Met Met Tyr Ser Pro 
    210                 215                 220                 


Gln Asn Ser Asp Tyr Leu Leu Ala Leu Ser Thr Glu Asn Gly Leu Trp 
225                 230                 235                 240 


Val Ser Lys Asn Phe Gly Gly Lys Trp Glu Glu Ile His Lys Ala Val 
                245                 250                 255     


Cys Leu Ala Lys Trp Gly Ser Asp Asn Thr Ile Phe Phe Thr Thr Tyr 
            260                 265                 270         


Ala Asn Gly Ser Cys Lys Ala Asp Leu Gly Ala Leu Glu Leu Trp Arg 
        275                 280                 285             


Thr Ser Asp Leu Gly Lys Ser Phe Lys Thr Ile Gly Val Lys Ile Tyr 
    290                 295                 300                 


Ser Phe Gly Leu Gly Gly Arg Phe Leu Phe Ala Ser Val Met Ala Asp 
305                 310                 315                 320 


Lys Asp Thr Thr Arg Arg Ile His Val Ser Thr Asp Gln Gly Asp Thr 
                325                 330                 335     


Trp Ser Met Ala Gln Leu Pro Ser Val Gly Gln Glu Gln Phe Tyr Ser 
            340                 345                 350         


Ile Leu Ala Ala Asn Asp Asp Met Val Phe Met His Val Asp Glu Pro 
        355                 360                 365             


Gly Asp Thr Gly Phe Gly Thr Ile Phe Thr Ser Asp Asp Arg Gly Ile 
    370                 375                 380                 


Val Tyr Ser Lys Ser Leu Asp Arg His Leu Tyr Thr Thr Thr Gly Gly 
385                 390                 395                 400 


Glu Thr Asp Phe Thr Asn Val Thr Ser Leu Arg Gly Val Tyr Ile Thr 
                405                 410                 415     


Ser Val Leu Ser Glu Asp Asn Ser Ile Gln Thr Met Ile Thr Phe Asp 
            420                 425                 430         


Gln Gly Gly Arg Trp Thr His Leu Arg Lys Pro Glu Asn Ser Glu Cys 
        435                 440                 445             


Asp Ala Thr Ala Lys Asn Lys Asn Glu Cys Ser Leu His Ile His Ala 
    450                 455                 460                 


Ser Tyr Ser Ile Ser Gln Lys Leu Asn Val Pro Met Ala Pro Leu Ser 
465                 470                 475                 480 


Glu Pro Asn Ala Val Gly Ile Val Ile Ala His Gly Ser Val Gly Asp 
                485                 490                 495     


Ala Ile Ser Val Met Val Pro Asp Val Tyr Ile Ser Asp Asp Gly Gly 
            500                 505                 510         


Tyr Ser Trp Thr Lys Met Leu Glu Gly Pro His Tyr Tyr Thr Ile Leu 
        515                 520                 525             


Asp Ser Gly Gly Ile Ile Val Ala Ile Glu His Ser Ser Arg Pro Ile 
    530                 535                 540                 


Asn Val Ile Lys Phe Ser Thr Asp Glu Gly Gln Cys Trp Gln Thr Tyr 
545                 550                 555                 560 


Thr Phe Thr Arg Asp Pro Ile Tyr Phe Thr Gly Leu Ala Ser Glu Pro 
                565                 570                 575     


Gly Ala Arg Ser Met Asn Ile Ser Ile Trp Gly Phe Thr Glu Ser Phe 
            580                 585                 590         


Leu Thr Ser Gln Trp Val Ser Tyr Thr Ile Asp Phe Lys Asp Ile Leu 
        595                 600                 605             


Glu Arg Asn Cys Glu Glu Lys Asp Tyr Thr Ile Trp Leu Ala His Ser 
    610                 615                 620                 


Thr Asp Pro Glu Asp Tyr Glu Asp Gly Cys Ile Leu Gly Tyr Lys Glu 
625                 630                 635                 640 


Gln Phe Leu Arg Leu Arg Lys Ser Ser Val Cys Gln Asn Gly Arg Asp 
                645                 650                 655     


Tyr Val Val Thr Lys Gln Pro Ser Ile Cys Leu Cys Ser Leu Glu Asp 
            660                 665                 670         


Phe Leu Cys Asp Phe Gly Tyr Tyr Arg Pro Glu Asn Asp Ser Lys Cys 
        675                 680                 685             


Val Glu Gln Pro Glu Leu Lys Gly His Asp Leu Glu Phe Cys Leu Tyr 
    690                 695                 700                 


Gly Arg Glu Glu His Leu Thr Thr Asn Gly Tyr Arg Lys Ile Pro Gly 
705                 710                 715                 720 


Asp Lys Cys Gln Gly Gly Val Asn Pro Val Arg Glu Val Lys Asp Leu 
                725                 730                 735     


Lys Lys Lys Cys Thr Ser Asn Phe Leu Ser Pro Glu Lys Gln Asn Ser 
            740                 745                 750         


Lys Ser Asn Ser Val Pro Ile Ile Leu Ala Ile Val Gly Leu Met Leu 
        755                 760                 765             


Val Thr Val Val Ala Gly Val Leu Ile Val Lys Lys Tyr Val Cys Gly 
    770                 775                 780                 


Gly Arg Phe Leu Val His Arg Tyr Ser Val Leu Gln Gln His Ala Glu 
785                 790                 795                 800 


Ala Asn Gly Val Asp Gly Val Asp Ala Leu Asp Thr Ala Ser His Thr 
                805                 810                 815     


Asn Lys Ser Gly Tyr His Asp Asp Ser Asp Glu Asp Leu Leu Glu 
            820                 825                 830     


<210>  340
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Tyr Gly Lys Gly Lys Ser Asn Ser Ser Ala Val Pro Ser Asp Ser 
1               5                   10                  15      


Gln Ala Arg Glu Lys Leu Ala Leu Tyr Val Tyr Glu Tyr Leu Leu His 
            20                  25                  30          


Val Gly Ala Gln Lys Ser Ala Gln Thr Phe Leu Ser Glu Ile Arg Trp 
        35                  40                  45              


Glu Lys Asn Ile Thr Leu Gly Glu Pro Pro Gly Phe Leu His Ser Trp 
    50                  55                  60                  


Trp Cys Val Phe Trp Asp Leu Tyr Cys Ala Ala Pro Glu Arg Arg Glu 
65                  70                  75                  80  


Thr Cys Glu His Ser Ser Glu Ala Lys Ala Phe His Asp Tyr Ser Ala 
                85                  90                  95      


Ala Ala Ala Pro Ser Pro Val Leu Gly Asn Ile Pro Pro Gly Asp Gly 
            100                 105                 110         


Met Pro Val Gly Pro Val Pro Pro Gly Phe Phe Gln Pro Phe Met Ser 
        115                 120                 125             


Pro Arg Tyr Pro Gly Gly Pro Arg Pro Pro Leu Arg Ile Pro Asn Gln 
    130                 135                 140                 


Ala Leu Gly Gly Val Pro Gly Ser Gln Pro Leu Leu Pro Ser Gly Met 
145                 150                 155                 160 


Asp Pro Thr Arg Gln Gln Gly His Pro Asn Met Gly Gly Pro Met Gln 
                165                 170                 175     


Arg Met Thr Pro Pro Arg Gly Met Val Pro Leu Gly Pro Gln Asn Tyr 
            180                 185                 190         


Gly Gly Ala Met Arg Pro Pro Leu Asn Ala Leu Gly Gly Pro Gly Met 
        195                 200                 205             


Pro Gly Met Asn Met Gly Pro Gly Gly Gly Arg Pro Trp Pro Asn Pro 
    210                 215                 220                 


Thr Asn Ala Asn Ser Ile Pro Tyr Ser Ser Ala Ser Pro Gly Asn Tyr 
225                 230                 235                 240 


Val Gly Pro Pro Gly Gly Gly Gly Pro Pro Gly Thr Pro Ile Met Pro 
                245                 250                 255     


Ser Pro Ala Asp Ser Thr Asn Ser Gly Asp Asn Met Tyr Thr Leu Met 
            260                 265                 270         


Asn Ala Val Pro Pro Gly Pro Asn Arg Pro Asn Phe Pro Met Gly Pro 
        275                 280                 285             


Gly Ser Asp Gly Pro Met Gly Gly Leu Gly Gly Met Glu Ser His His 
    290                 295                 300                 


Met Asn Gly Ser Leu Gly Ser Gly Asp Met Asp Ser Ile Ser Lys Asn 
305                 310                 315                 320 


Ser Pro Asn Asn Met Ser Leu Ser Asn Gln Pro Gly Thr Pro Arg Asp 
                325                 330                 335     


Asp Gly Glu Met Gly Gly Asn Phe Leu Asn Pro Phe Gln Ser Glu Ser 
            340                 345                 350         


Tyr Ser Pro Ser Met Thr Met Ser Val 
        355                 360     


<210>  341
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Arg Thr Lys Ala Ala Gly Cys Ala Glu Arg Arg Pro Leu Gln Pro 
1               5                   10                  15      


Arg Thr Glu Ala Ala Ala Ala Pro Ala Gly Arg Ala Met Pro Ser Glu 
            20                  25                  30          


Tyr Thr Tyr Val Lys Leu Arg Ser Asp Cys Ser Arg Pro Ser Leu Gln 
        35                  40                  45              


Trp Tyr Thr Arg Ala Gln Ser Lys Met Arg Arg Pro Ser Leu Leu Leu 
    50                  55                  60                  


Lys Asp Ile Leu Lys Cys Thr Leu Leu Val Phe Gly Val Trp Ile Leu 
65                  70                  75                  80  


Tyr Ile Leu Lys Leu Asn Tyr Thr Thr Glu Glu Cys Asp Met Lys Lys 
                85                  90                  95      


Met His Tyr Val Asp Pro Asp His Val Lys Arg Ala Gln Lys Tyr Ala 
            100                 105                 110         


Gln Gln Val Leu Gln Lys Glu Cys Arg Pro Lys Phe Ala Lys Thr Ser 
        115                 120                 125             


Met Ala Leu Leu Phe Glu His Arg Tyr Ser Val Asp Leu Leu Pro Phe 
    130                 135                 140                 


Val Gln Lys Ala Pro Lys Asp Ser Glu Ala Glu Ser Lys Tyr Asp Pro 
145                 150                 155                 160 


Pro Phe Gly Phe Arg Lys Phe Ser Ser Lys Val Gln Thr Leu Leu Glu 
                165                 170                 175     


Leu Leu Pro Glu His Asp Leu Pro Glu His Leu Lys Ala Lys Thr Cys 
            180                 185                 190         


Arg Arg Cys Val Val Ile Gly Ser Gly Gly Ile Leu His Gly Leu Glu 
        195                 200                 205             


Leu Gly His Thr Leu Asn Gln Phe Asp Val Val Ile Arg Leu Asn Ser 
    210                 215                 220                 


Ala Pro Val Glu Gly Tyr Ser Glu His Val Gly Asn Lys Thr Thr Ile 
225                 230                 235                 240 


Arg Met Thr Tyr Pro Glu Gly Ala Pro Leu Ser Asp Leu Glu Tyr Tyr 
                245                 250                 255     


Ser Asn Asp Leu Phe Val Ala Val Leu Phe Lys Ser Val Asp Phe Asn 
            260                 265                 270         


Trp Leu Gln Ala Met Val Lys Lys Glu Thr Leu Pro Phe Trp Val Arg 
        275                 280                 285             


Leu Phe Phe Trp Lys Gln Val Ala Glu Lys Ile Pro Leu Gln Pro Lys 
    290                 295                 300                 


His Phe Arg Ile Leu Asn Pro Val Ile Ile Lys Glu Thr Ala Phe Asp 
305                 310                 315                 320 


Ile Leu Gln Tyr Ser Glu Pro Gln Ser Arg Phe Trp Gly Arg Asp Lys 
                325                 330                 335     


Asn Val Pro Thr Ile Gly Val Ile Ala Val Val Leu Ala Thr His Leu 
            340                 345                 350         


Cys Asp Glu Val Ser Leu Ala Gly Phe Gly Tyr Asp Leu Asn Gln Pro 
        355                 360                 365             


Arg Thr Pro Leu His Tyr Phe Asp Ser Gln Cys Met Ala Ala Met Asn 
    370                 375                 380                 


Phe Gln Thr Met His Asn Val Thr Thr Glu Thr Lys Phe Leu Leu Lys 
385                 390                 395                 400 


Leu Val Lys Glu Gly Val Val Lys Asp Leu Ser Gly Gly Ile Asp Arg 
                405                 410                 415     


Glu Phe 
        


<210>  342
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Arg Gly Tyr Leu Val Ala Ile Phe Leu Ser Ala Val Phe Leu Tyr 
1               5                   10                  15      


Tyr Val Leu His Cys Ile Leu Trp Gly Thr Asn Val Tyr Trp Val Ala 
            20                  25                  30          


Pro Val Glu Met Lys Arg Arg Asn Lys Ile Gln Pro Cys Leu Ser Lys 
        35                  40                  45              


Pro Ala Phe Ala Ser Leu Leu Arg Phe His Gln Phe His Pro Phe Leu 
    50                  55                  60                  


Cys Ala Ala Asp Phe Arg Lys Ile Ala Ser Leu Tyr Gly Ser Asp Lys 
65                  70                  75                  80  


Phe Asp Leu Pro Tyr Gly Met Arg Thr Ser Ala Glu Tyr Phe Arg Leu 
                85                  90                  95      


Ala Leu Ser Lys Leu Gln Ser Cys Asp Leu Phe Asp Glu Phe Asp Asn 
            100                 105                 110         


Ile Pro Cys Lys Lys Cys Val Val Val Gly Asn Gly Gly Val Leu Lys 
        115                 120                 125             


Asn Lys Thr Leu Gly Glu Lys Ile Asp Ser Tyr Asp Val Ile Ile Arg 
    130                 135                 140                 


Met Asn Asn Gly Pro Val Leu Gly His Glu Glu Glu Val Gly Arg Arg 
145                 150                 155                 160 


Thr Thr Phe Arg Leu Phe Tyr Pro Glu Ser Val Phe Ser Asp Pro Ile 
                165                 170                 175     


His Asn Asp Pro Asn Thr Thr Val Ile Leu Thr Ala Phe Lys Pro His 
            180                 185                 190         


Asp Leu Arg Trp Leu Leu Glu Leu Leu Met Gly Asp Lys Ile Asn Thr 
        195                 200                 205             


Asn Gly Phe Trp Lys Lys Pro Ala Leu Asn Leu Ile Tyr Lys Pro Tyr 
    210                 215                 220                 


Gln Ile Arg Ile Leu Asp Pro Phe Ile Ile Arg Thr Ala Ala Tyr Glu 
225                 230                 235                 240 


Leu Leu His Phe Pro Lys Val Phe Pro Lys Asn Gln Lys Pro Lys His 
                245                 250                 255     


Pro Thr Thr Gly Ile Ile Ala Ile Thr Leu Ala Phe Tyr Ile Cys His 
            260                 265                 270         


Glu Val His Leu Ala Gly Phe Lys Tyr Asn Phe Ser Asp Leu Lys Ser 
        275                 280                 285             


Pro Leu His Tyr Tyr Gly Asn Ala Thr Met Ser Leu Met Asn Lys Asn 
    290                 295                 300                 


Ala Tyr His Asn Val Thr Ala Glu Gln Leu Phe Leu Lys Asp Ile Ile 
305                 310                 315                 320 


Glu Lys Asn Leu Val Ile Asn Leu Thr Gln Asp 
                325                 330     


<210>  343
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Ala Met Thr Gly Ser Thr Pro Cys Ser Ser Met Ser Asn His Thr 
1               5                   10                  15      


Lys Glu Arg Val Thr Met Thr Lys Val Thr Leu Glu Asn Phe Tyr Ser 
            20                  25                  30          


Asn Leu Ile Ala Gln His Glu Glu Arg Glu Met Arg Gln Lys Lys Leu 
        35                  40                  45              


Glu Lys Val Met Glu Glu Glu Gly Leu Lys Asp Glu Glu Lys Arg Leu 
    50                  55                  60                  


Arg Arg Ser Ala His Ala Arg Lys Glu Thr Glu Phe Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Thr Arg Leu Gly Leu Glu Asp Phe Glu Ser Leu Lys Val Ile Gly 
                85                  90                  95      


Arg Gly Ala Phe Gly Glu Val Arg Leu Val Gln Lys Lys Asp Thr Gly 
            100                 105                 110         


His Val Tyr Ala Met Lys Ile Leu Arg Lys Ala Asp Met Leu Glu Lys 
        115                 120                 125             


Glu Gln Val Gly His Ile Arg Ala Glu Arg Asp Ile Leu Val Glu Ala 
    130                 135                 140                 


Asp Ser Leu Trp Val Val Lys Met Phe Tyr Ser Phe Gln Asp Lys Leu 
145                 150                 155                 160 


Asn Leu Tyr Leu Ile Met Glu Phe Leu Pro Gly Gly Asp Met Met Thr 
                165                 170                 175     


Leu Leu Met Lys Lys Asp Thr Leu Thr Glu Glu Glu Thr Gln Phe Tyr 
            180                 185                 190         


Ile Ala Glu Thr Val Leu Ala Ile Asp Ser Ile His Gln Leu Gly Phe 
        195                 200                 205             


Ile His Arg Asp Ile Lys Pro Asp Asn Leu Leu Leu Asp Ser Lys Gly 
    210                 215                 220                 


His Val Lys Leu Ser Asp Phe Gly Leu Cys Thr Gly Leu Lys Lys Ala 
225                 230                 235                 240 


His Arg Thr Glu Phe Tyr Arg Asn Leu Asn His Ser Leu Pro Ser Asp 
                245                 250                 255     


Phe Thr Phe Gln Asn Met Asn Ser Lys Arg Lys Ala Glu Thr Trp Lys 
            260                 265                 270         


Arg Asn Arg Arg Gln Leu Ala Phe Ser Thr Val Gly Thr Pro Asp Tyr 
        275                 280                 285             


Ile Ala Pro Glu Val Phe Met Gln Thr Gly Tyr Asn Lys Leu Cys Asp 
    290                 295                 300                 


Trp Trp Ser Leu Gly Val Ile Met Tyr Glu Met Leu Ile Gly Tyr Pro 
305                 310                 315                 320 


Pro Phe Cys Ser Glu Thr Pro Gln Glu Thr Tyr Lys Lys Val Met Asn 
                325                 330                 335     


Trp Lys Glu Thr Leu Thr Phe Pro Pro Glu Val Pro Ile Ser Glu Lys 
            340                 345                 350         


Ala Lys Asp Leu Ile Leu Arg Phe Cys Cys Glu Trp Glu His Arg Ile 
        355                 360                 365             


Gly Ala Pro Gly Val Glu Glu Ile Lys Ser Asn Ser Phe Phe Glu Gly 
    370                 375                 380                 


Val Asp Trp Glu His Ile Arg Glu Arg Pro Ala Ala Ile Ser Ile Glu 
385                 390                 395                 400 


Ile Lys Ser Ile Asp Asp Thr Ser Asn Phe Asp Glu Phe Pro Glu Ser 
                405                 410                 415     


Asp Ile Leu Lys Pro Thr Val Ala Thr Ser Asn His Pro Glu Thr Asp 
            420                 425                 430         


Tyr Lys Asn Lys Asp Trp Val Phe Ile Asn Tyr Thr Tyr Lys Arg Phe 
        435                 440                 445             


Glu Gly Leu Thr Ala Arg Gly Ala Ile Pro Ser Tyr Met Lys Ala Ala 
    450                 455                 460                 


Lys 
465 


<210>  344
<211>  6885
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Ala Ser Ser Pro Glu Leu Pro Thr Glu Asp Glu Gln Gly Ser Trp 
1               5                   10                  15      


Gly Ile Asp Asp Leu His Ile Ser Leu Gln Ala Glu Gln Glu Asp Thr 
            20                  25                  30          


Gln Lys Lys Ala Phe Thr Cys Trp Ile Asn Ser Gln Leu Ala Arg His 
        35                  40                  45              


Thr Ser Pro Ser Val Ile Ser Asp Leu Phe Thr Asp Ile Lys Lys Gly 
    50                  55                  60                  


His Val Leu Leu Asp Leu Leu Glu Val Leu Ser Gly Gln Gln Leu Pro 
65                  70                  75                  80  


Arg Asp Lys Gly Ser Asn Thr Phe Gln Cys Arg Ile Asn Ile Glu His 
                85                  90                  95      


Ala Leu Thr Phe Leu Arg Asn Arg Ser Ile Lys Leu Ile Asn Ile His 
            100                 105                 110         


Val Thr Asp Ile Ile Asp Gly Asn Pro Ser Ile Ile Leu Gly Leu Ile 
        115                 120                 125             


Trp Thr Ile Ile Leu His Phe His Ile Glu Lys Leu Ala Gln Thr Leu 
    130                 135                 140                 


Ser Cys Asn Tyr Asn Gln Pro Ser Leu Asp Asp Val Ser Val Val Asp 
145                 150                 155                 160 


Ser Ser Pro Ala Ser Ser Pro Pro Ala Lys Lys Cys Ser Lys Val Gln 
                165                 170                 175     


Ala Arg Trp Gln Met Ser Ala Arg Lys Ala Leu Leu Leu Trp Ala Gln 
            180                 185                 190         


Glu Gln Cys Ala Thr Tyr Glu Ser Val Asn Val Thr Asp Phe Lys Ser 
        195                 200                 205             


Ser Trp Arg Asn Gly Met Ala Phe Leu Ala Ile Ile His Ala Leu Arg 
    210                 215                 220                 


Pro Asp Leu Ile Asp Met Lys Ser Val Lys His Arg Ser Asn Lys Asp 
225                 230                 235                 240 


Asn Leu Arg Glu Ala Phe Arg Ile Ala Glu Gln Glu Leu Lys Ile Pro 
                245                 250                 255     


Arg Leu Leu Glu Pro Glu Asp Val Asp Val Val Asp Pro Asp Glu Lys 
            260                 265                 270         


Ser Ile Met Thr Tyr Val Ala Gln Phe Leu Gln Tyr Ser Lys Asp Ala 
        275                 280                 285             


Pro Gly Thr Gly Glu Glu Ala Gln Gly Lys Val Lys Asp Ala Met Gly 
    290                 295                 300                 


Trp Leu Thr Leu Gln Lys Glu Lys Leu Gln Lys Leu Leu Lys Asp Ser 
305                 310                 315                 320 


Glu Asn Asp Thr Tyr Phe Lys Lys Tyr Asn Ser Leu Leu Ser Phe Met 
                325                 330                 335     


Glu Ser Phe Asn Glu Glu Lys Lys Ser Phe Leu Asp Val Leu Ser Ile 
            340                 345                 350         


Lys Arg Asp Leu Asp Glu Leu Asp Lys Asp His Leu Gln Leu Arg Glu 
        355                 360                 365             


Ala Trp Asp Gly Leu Asp His Gln Ile Asn Ala Trp Lys Ile Lys Leu 
    370                 375                 380                 


Asn Tyr Ala Leu Pro Pro Pro Leu His Gln Thr Glu Ala Trp Leu Gln 
385                 390                 395                 400 


Glu Val Glu Glu Leu Met Asp Glu Asp Leu Ser Ala Ser Gln Asp His 
                405                 410                 415     


Ser Gln Ala Val Thr Leu Ile Gln Glu Lys Met Thr Leu Phe Lys Ser 
            420                 425                 430         


Leu Met Asp Arg Phe Glu His His Ser Asn Ile Leu Leu Thr Phe Glu 
        435                 440                 445             


Asn Lys Asp Glu Asn His Leu Pro Leu Val Pro Pro Asn Lys Leu Glu 
    450                 455                 460                 


Glu Met Lys Arg Arg Ile Asn Asn Ile Leu Glu Lys Lys Phe Ile Leu 
465                 470                 475                 480 


Leu Leu Glu Phe His Tyr Tyr Lys Cys Leu Val Leu Gly Leu Val Asp 
                485                 490                 495     


Glu Val Lys Ser Lys Leu Asp Ile Trp Asn Ile Lys Tyr Gly Ser Arg 
            500                 505                 510         


Glu Ser Val Glu Leu Leu Leu Glu Asp Trp His Lys Phe Ile Glu Glu 
        515                 520                 525             


Lys Glu Phe Leu Ala Arg Leu Asp Thr Ser Phe Gln Lys Cys Gly Glu 
    530                 535                 540                 


Ile Tyr Lys Asn Leu Ala Gly Glu Cys Gln Asn Ile Asn Lys Gln Tyr 
545                 550                 555                 560 


Met Met Val Lys Ser Asp Val Cys Met Tyr Arg Lys Asn Ile Tyr Asn 
                565                 570                 575     


Val Lys Ser Thr Leu Gln Lys Val Leu Ala Cys Trp Ala Thr Tyr Val 
            580                 585                 590         


Glu Asn Leu Arg Leu Leu Arg Ala Cys Phe Glu Glu Thr Lys Lys Glu 
        595                 600                 605             


Glu Ile Lys Glu Val Pro Phe Glu Thr Leu Ala Gln Trp Asn Leu Glu 
    610                 615                 620                 


His Ala Thr Leu Asn Glu Ala Gly Asn Phe Leu Val Glu Val Ser Asn 
625                 630                 635                 640 


Asp Val Val Gly Ser Ser Ile Ser Lys Glu Leu Arg Arg Leu Asn Lys 
                645                 650                 655     


Arg Trp Arg Lys Leu Val Ser Lys Thr Gln Leu Glu Met Asn Leu Pro 
            660                 665                 670         


Leu Met Ile Lys Lys Gln Asp Gln Pro Thr Phe Asp Asn Ser Gly Asn 
        675                 680                 685             


Ile Leu Ser Lys Glu Glu Lys Ala Thr Val Glu Phe Ser Thr Asp Met 
    690                 695                 700                 


Ser Val Glu Leu Pro Glu Asn Tyr Asn Gln Asn Ile Lys Ala Gly Glu 
705                 710                 715                 720 


Lys His Glu Lys Glu Asn Glu Glu Phe Thr Gly Gln Leu Lys Val Ala 
                725                 730                 735     


Lys Asp Val Glu Lys Leu Ile Gly Gln Val Glu Ile Trp Glu Ala Glu 
            740                 745                 750         


Ala Lys Ser Val Leu Asp Gln Asp Asp Val Asp Thr Ser Met Glu Glu 
        755                 760                 765             


Ser Leu Lys His Leu Ile Ala Lys Gly Ser Met Phe Asp Glu Leu Met 
    770                 775                 780                 


Ala Arg Ser Glu Asp Met Leu Gln Met Asp Ile Gln Asn Ile Ser Ser 
785                 790                 795                 800 


Gln Glu Ser Phe Gln His Val Leu Thr Thr Gly Leu Gln Ala Lys Ile 
                805                 810                 815     


Gln Glu Ala Lys Glu Lys Val Gln Ile Asn Val Val Lys Leu Ile Ala 
            820                 825                 830         


Ala Leu Lys Asn Leu Thr Asp Val Ser Pro Asp Leu Asp Ile Arg Leu 
        835                 840                 845             


Lys Met Glu Glu Ser Gln Lys Glu Leu Glu Ser Tyr Met Met Arg Ala 
    850                 855                 860                 


Gln Gln Leu Leu Gly Gln Arg Glu Ser Pro Gly Glu Leu Ile Ser Lys 
865                 870                 875                 880 


His Lys Glu Ala Leu Ile Ile Ser Asn Thr Lys Ser Leu Ala Lys Tyr 
                885                 890                 895     


Leu Lys Ala Val Glu Glu Leu Lys Asn Asn Val Thr Glu Asp Ile Lys 
            900                 905                 910         


Met Ser Leu Glu Glu Lys Ser Arg Asp Val Cys Ala Lys Trp Glu Ser 
        915                 920                 925             


Leu His His Glu Leu Ser Leu Tyr Val Gln Gln Leu Lys Ile Asp Ile 
    930                 935                 940                 


Glu Lys Gly Lys Leu Ser Asp Asn Ile Leu Lys Leu Glu Lys Gln Ile 
945                 950                 955                 960 


Asn Lys Glu Lys Lys Leu Ile Arg Arg Gly Arg Thr Lys Gly Leu Ile 
                965                 970                 975     


Lys Glu His Glu Ala Cys Phe Ser Glu Glu Gly Cys Leu Tyr Gln Leu 
            980                 985                 990         


Asn His His Met Glu Val Leu Arg  Glu Leu Cys Glu Glu  Leu Pro Ser 
        995                 1000                 1005             


Gln Lys  Ser Gln Gln Glu Val  Lys Arg Leu Leu Lys  Asp Tyr Glu 
    1010                 1015                 1020             


Gln Lys  Ile Glu Arg Leu Leu  Lys Cys Ala Ser Glu  Ile His Met 
    1025                 1030                 1035             


Thr Leu  Gln Pro Thr Ala Gly  Gly Thr Ser Lys Asn  Glu Gly Thr 
    1040                 1045                 1050             


Ile Thr  Thr Ser Glu Asn Arg  Gly Gly Asp Pro His  Ser Glu Ala 
    1055                 1060                 1065             


Pro Phe  Ala Lys Ser Asp Asn  Gln Pro Ser Thr Glu  Lys Ala Met 
    1070                 1075                 1080             


Glu Pro  Thr Met Lys Phe Ser  Leu Ala Ser Val Leu  Arg Pro Leu 
    1085                 1090                 1095             


Gln Glu  Glu Ser Ile Met Glu  Lys Asp Tyr Ser Ala  Ser Ile Asn 
    1100                 1105                 1110             


Ser Leu  Leu Glu Arg Tyr Asp  Thr Tyr Arg Asp Ile  Leu Glu His 
    1115                 1120                 1125             


His Leu  Gln Asn Asn Lys Phe  Arg Ile Thr Ser Asp  Phe Ser Ser 
    1130                 1135                 1140             


Glu Glu  Asp Arg Ser Ser Ser  Cys Leu Gln Ala Lys  Leu Thr Asp 
    1145                 1150                 1155             


Leu Gln  Val Ile Lys Asn Glu  Thr Asp Ala Arg Trp  Lys Glu Phe 
    1160                 1165                 1170             


Glu Ile  Ile Ser Leu Lys Leu  Glu Asn His Val Asn  Asp Ile Lys 
    1175                 1180                 1185             


Lys Pro  Phe Val Ile Lys Glu  Arg Asp Thr Leu Lys  Glu Arg Glu 
    1190                 1195                 1200             


Arg Glu  Leu Gln Met Thr Leu  Asn Thr Arg Met Glu  Ser Leu Glu 
    1205                 1210                 1215             


Thr Ala  Leu Arg Leu Val Leu  Pro Val Glu Lys Ala  Ser Leu Leu 
    1220                 1225                 1230             


Leu Cys  Gly Ser Asp Leu Pro  Leu His Lys Met Ala  Ile Gln Gly 
    1235                 1240                 1245             


Phe His  Leu Ile Asp Ala Asp  Arg Ile Tyr Gln His  Leu Arg Asn 
    1250                 1255                 1260             


Ile Gln  Asp Ser Ile Ala Lys  Gln Ile Glu Ile Cys  Asn Arg Leu 
    1265                 1270                 1275             


Glu Glu  Pro Gly Asn Phe Val  Leu Lys Glu Leu His  Pro Phe Asp 
    1280                 1285                 1290             


Leu His  Ala Met Gln Asn Ile  Ile Leu Lys Tyr Lys  Thr Gln Phe 
    1295                 1300                 1305             


Glu Gly  Met Asn His Arg Val  Gln Arg Ser Glu Asp  Thr Leu Lys 
    1310                 1315                 1320             


Ala Leu  Glu Asp Phe Leu Ala  Ser Leu Arg Thr Ala  Lys Leu Ser 
    1325                 1330                 1335             


Ala Glu  Pro Val Thr Asp Leu  Ser Ala Ser Asp Thr  Gln Val Ala 
    1340                 1345                 1350             


Gln Glu  Asn Thr Leu Thr Val  Lys Asn Lys Glu Gly  Glu Ile His 
    1355                 1360                 1365             


Leu Met  Lys Asp Lys Ala Lys  His Leu Asp Lys Cys  Leu Lys Met 
    1370                 1375                 1380             


Leu Asp  Met Ser Phe Lys Asp  Ala Glu Arg Gly Asp  Asp Thr Ser 
    1385                 1390                 1395             


Cys Glu  Asn Leu Leu Asp Ala  Phe Ser Ile Lys Leu  Ser Glu Thr 
    1400                 1405                 1410             


His Gly  Tyr Gly Val Gln Glu  Glu Phe Thr Glu Glu  Asn Lys Leu 
    1415                 1420                 1425             


Leu Glu  Ala Cys Ile Phe Lys  Asn Asn Glu Leu Leu  Lys Asn Ile 
    1430                 1435                 1440             


Gln Asp  Val Gln Ser Gln Ile  Ser Lys Ile Gly Leu  Lys Asp Pro 
    1445                 1450                 1455             


Thr Val  Pro Ala Val Lys His  Arg Lys Lys Ser Leu  Ile Arg Leu 
    1460                 1465                 1470             


Asp Lys  Val Leu Asp Glu Tyr  Glu Glu Glu Lys Arg  His Leu Gln 
    1475                 1480                 1485             


Glu Met  Ala Asn Ser Leu Pro  His Phe Lys Asp Gly  Arg Glu Lys 
    1490                 1495                 1500             


Thr Val  Asn Gln Gln Cys Gln  Asn Thr Val Val Leu  Trp Glu Asn 
    1505                 1510                 1515             


Thr Lys  Ala Leu Val Thr Glu  Cys Leu Glu Gln Cys  Gly Arg Val 
    1520                 1525                 1530             


Leu Glu  Leu Leu Lys Gln Tyr  Gln Asn Phe Lys Ser  Ile Leu Thr 
    1535                 1540                 1545             


Thr Leu  Ile Gln Lys Glu Glu  Ser Val Ile Ser Leu  Gln Ala Ser 
    1550                 1555                 1560             


Tyr Met  Gly Lys Glu Asn Leu  Lys Lys Arg Ile Ala  Glu Ile Glu 
    1565                 1570                 1575             


Ile Val  Lys Glu Glu Phe Asn  Glu His Leu Glu Val  Val Asp Lys 
    1580                 1585                 1590             


Ile Asn  Gln Val Cys Lys Asn  Leu Gln Phe Tyr Leu  Asn Lys Met 
    1595                 1600                 1605             


Lys Thr  Phe Glu Glu Pro Pro  Phe Glu Lys Glu Ala  Asn Ile Ile 
    1610                 1615                 1620             


Val Asp  Arg Trp Leu Asp Ile  Asn Glu Lys Thr Glu  Asp Tyr Tyr 
    1625                 1630                 1635             


Glu Asn  Leu Gly Arg Ala Leu  Ala Leu Trp Asp Lys  Leu Phe Asn 
    1640                 1645                 1650             


Leu Lys  Asn Val Ile Asp Glu  Trp Thr Glu Lys Ala  Leu Gln Lys 
    1655                 1660                 1665             


Met Glu  Leu His Gln Leu Thr  Glu Glu Asp Arg Glu  Arg Leu Lys 
    1670                 1675                 1680             


Glu Glu  Leu Gln Val His Glu  Gln Lys Thr Ser Glu  Phe Ser Arg 
    1685                 1690                 1695             


Arg Val  Ala Glu Ile Gln Phe  Leu Leu Gln Ser Ser  Glu Ile Pro 
    1700                 1705                 1710             


Leu Glu  Leu Gln Val Met Glu  Ser Ser Ile Leu Asn  Lys Met Glu 
    1715                 1720                 1725             


His Val  Gln Lys Cys Leu Thr  Gly Glu Ser Asn Cys  His Ala Leu 
    1730                 1735                 1740             


Ser Gly  Ser Thr Ala Glu Leu  Arg Glu Asp Leu Asp  Gln Ala Lys 
    1745                 1750                 1755             


Thr Gln  Ile Gly Met Thr Glu  Ser Leu Leu Lys Ala  Leu Ser Pro 
    1760                 1765                 1770             


Ser Asp  Ser Leu Glu Ile Phe  Thr Lys Leu Glu Glu  Ile Gln Gln 
    1775                 1780                 1785             


Gln Ile  Leu Gln Gln Lys His  Ser Met Ile Leu Leu  Glu Asn Gln 
    1790                 1795                 1800             


Ile Gly  Cys Leu Thr Pro Glu  Leu Ser Glu Leu Lys  Lys Gln Tyr 
    1805                 1810                 1815             


Glu Ser  Val Ser Asp Leu Phe  Asn Thr Lys Lys Ser  Val Leu Gln 
    1820                 1825                 1830             


Asp His  Phe Ser Lys Leu Leu  Asn Asp Gln Cys Lys  Asn Phe Asn 
    1835                 1840                 1845             


Asp Trp  Phe Ser Asn Ile Lys  Val Asn Leu Lys Glu  Cys Phe Glu 
    1850                 1855                 1860             


Ser Ser  Glu Thr Lys Lys Ser  Val Glu Gln Lys Leu  Gln Lys Leu 
    1865                 1870                 1875             


Ser Asp  Phe Leu Thr Leu Glu  Gly Arg Asn Ser Lys  Ile Lys Gln 
    1880                 1885                 1890             


Val Asp  Ser Val Leu Lys His  Val Lys Lys His Leu  Pro Lys Ala 
    1895                 1900                 1905             


His Val  Lys Glu Leu Ile Ser  Trp Leu Val Gly Gln  Glu Phe Glu 
    1910                 1915                 1920             


Leu Glu  Lys Met Glu Ser Ile  Cys Gln Ala Arg Ala  Lys Glu Leu 
    1925                 1930                 1935             


Glu Asp  Ser Leu Gln Gln Leu  Leu Arg Leu Gln Asp  Asp His Arg 
    1940                 1945                 1950             


Asn Leu  Arg Lys Trp Leu Thr  Asn Gln Glu Glu Lys  Trp Lys Gly 
    1955                 1960                 1965             


Met Glu  Glu Pro Gly Glu Lys  Thr Glu Leu Phe Cys  Gln Ala Leu 
    1970                 1975                 1980             


Ala Arg  Lys Arg Glu Gln Phe  Glu Ser Val Ala Gln  Leu Asn Asn 
    1985                 1990                 1995             


Ser Leu  Lys Glu Tyr Gly Phe  Thr Glu Glu Glu Glu  Ile Ile Met 
    2000                 2005                 2010             


Glu Ala  Thr Cys Leu Met Asp  Arg Tyr Gln Thr Leu  Leu Arg Gln 
    2015                 2020                 2025             


Leu Ser  Glu Ile Glu Glu Glu  Asp Lys Leu Leu Pro  Thr Glu Asp 
    2030                 2035                 2040             


Gln Ser  Phe Asn Asp Leu Ala  His Asp Val Ile His  Trp Ile Lys 
    2045                 2050                 2055             


Glu Ile  Lys Glu Ser Leu Met  Val Leu Asn Ser Ser  Glu Gly Lys 
    2060                 2065                 2070             


Met Pro  Leu Glu Glu Arg Ile  Gln Lys Ile Lys Glu  Ile Ile Leu 
    2075                 2080                 2085             


Leu Lys  Pro Glu Gly Asp Ala  Arg Ile Glu Thr Ile  Met Lys Gln 
    2090                 2095                 2100             


Ala Glu  Ser Ser Glu Ala Pro  Leu Val Gln Lys Thr  Leu Thr Asp 
    2105                 2110                 2115             


Ile Ser  Asn Gln Trp Asp Asn  Thr Leu His Leu Ala  Ser Thr Tyr 
    2120                 2125                 2130             


Leu Ser  His Gln Glu Lys Leu  Leu Leu Glu Gly Glu  Lys Tyr Leu 
    2135                 2140                 2145             


Gln Ser  Lys Glu Asp Leu Arg  Leu Met Leu Ile Glu  Leu Lys Lys 
    2150                 2155                 2160             


Lys Gln  Glu Ala Gly Phe Ala  Leu Gln His Gly Leu  Gln Glu Lys 
    2165                 2170                 2175             


Lys Ala  Gln Leu Lys Ile Tyr  Lys Lys Phe Leu Lys  Lys Ala Gln 
    2180                 2185                 2190             


Asp Leu  Thr Ser Leu Leu Lys  Glu Leu Lys Ser Gln  Gly Asn Tyr 
    2195                 2200                 2205             


Leu Leu  Glu Cys Thr Lys Asn  Pro Ser Phe Ser Glu  Glu Pro Trp 
    2210                 2215                 2220             


Leu Glu  Ile Lys His Leu His  Glu Ser Leu Leu Gln  Gln Leu Gln 
    2225                 2230                 2235             


Asp Ser  Val Gln Asn Leu Asp  Gly His Val Arg Glu  His Asp Ser 
    2240                 2245                 2250             


Tyr Gln  Val Cys Val Thr Asp  Leu Asn Thr Thr Leu  Asp Asn Phe 
    2255                 2260                 2265             


Ser Lys  Glu Phe Val Ser Phe  Ser Asp Lys Pro Val  Asp Gln Ile 
    2270                 2275                 2280             


Ala Val  Glu Glu Lys Leu Gln  Lys Leu Gln Glu Leu  Glu Asn Arg 
    2285                 2290                 2295             


Leu Ser  Leu Gln Asp Gly Thr  Leu Lys Lys Ile Leu  Ala Leu Ala 
    2300                 2305                 2310             


Lys Ser  Val Lys Gln Asn Thr  Ser Ser Val Gly Gln  Lys Ile Ile 
    2315                 2320                 2325             


Lys Asp  Asp Ile Lys Ser Leu  Gln Cys Lys Gln Lys  Asp Leu Glu 
    2330                 2335                 2340             


Asn Arg  Leu Ala Ser Ala Lys  Gln Glu Met Glu Cys  Cys Leu Asn 
    2345                 2350                 2355             


Ser Ile  Leu Lys Ser Lys Arg  Ser Thr Glu Lys Lys  Gly Lys Phe 
    2360                 2365                 2370             


Thr Leu  Pro Gly Arg Glu Lys  Gln Ala Thr Ser Asp  Val Gln Glu 
    2375                 2380                 2385             


Ser Thr  Gln Glu Ser Ala Ala  Val Glu Lys Leu Glu  Glu Asp Trp 
    2390                 2395                 2400             


Glu Ile  Asn Lys Asp Ser Ala  Val Glu Met Ala Met  Ser Lys Gln 
    2405                 2410                 2415             


Leu Ser  Leu Asn Ala Gln Glu  Ser Met Lys Asn Thr  Glu Asp Glu 
    2420                 2425                 2430             


Arg Lys  Val Asn Glu Leu Gln  Asn Gln Pro Leu Glu  Leu Asp Thr 
    2435                 2440                 2445             


Met Leu  Arg Asn Glu Gln Leu  Glu Glu Ile Glu Lys  Leu Tyr Thr 
    2450                 2455                 2460             


Gln Leu  Glu Ala Lys Lys Ala  Ala Ile Lys Pro Leu  Glu Gln Thr 
    2465                 2470                 2475             


Glu Cys  Leu Asn Lys Thr Glu  Thr Gly Ala Leu Val  Leu His Asn 
    2480                 2485                 2490             


Ile Gly  Tyr Ser Ala Gln His  Leu Asp Asn Leu Leu  Gln Ala Leu 
    2495                 2500                 2505             


Ile Thr  Leu Lys Lys Asn Lys  Glu Ser Gln Tyr Cys  Val Leu Arg 
    2510                 2515                 2520             


Asp Phe  Gln Glu Tyr Leu Ala  Ala Val Glu Ser Ser  Met Lys Ala 
    2525                 2530                 2535             


Leu Leu  Thr Asp Lys Glu Ser  Leu Lys Val Gly Pro  Leu Asp Ser 
    2540                 2545                 2550             


Val Thr  Tyr Leu Asp Lys Ile  Lys Lys Phe Ile Ala  Ser Ile Glu 
    2555                 2560                 2565             


Lys Glu  Lys Asp Ser Leu Gly  Asn Leu Lys Ile Lys  Trp Glu Asn 
    2570                 2575                 2580             


Leu Ser  Asn His Val Thr Asp  Met Asp Lys Lys Leu  Leu Glu Ser 
    2585                 2590                 2595             


Gln Ile  Lys Gln Leu Glu His  Gly Trp Glu Gln Val  Glu Gln Gln 
    2600                 2605                 2610             


Ile Gln  Lys Lys Tyr Ser Gln  Gln Val Val Glu Tyr  Asp Glu Phe 
    2615                 2620                 2625             


Thr Thr  Leu Met Asn Lys Val  Gln Asp Thr Glu Ile  Ser Leu Gln 
    2630                 2635                 2640             


Gln Gln  Gln Gln His Leu Gln  Leu Arg Leu Lys Ser  Pro Glu Glu 
    2645                 2650                 2655             


Arg Ala  Gly Asn Gln Ser Met  Ile Ala Leu Thr Thr  Asp Leu Gln 
    2660                 2665                 2670             


Ala Thr  Lys His Gly Phe Ser  Val Leu Lys Gly Gln  Ala Glu Leu 
    2675                 2680                 2685             


Gln Met  Lys Arg Ile Trp Gly  Glu Lys Glu Lys Lys  Asn Leu Glu 
    2690                 2695                 2700             


Asp Gly  Ile Asn Asn Leu Lys  Lys Gln Trp Glu Thr  Leu Glu Pro 
    2705                 2710                 2715             


Leu His  Leu Glu Ala Glu Asn  Gln Ile Lys Lys Cys  Asp Ile Arg 
    2720                 2725                 2730             


Asn Lys  Met Lys Glu Thr Ile  Leu Trp Ala Lys Asn  Leu Leu Gly 
    2735                 2740                 2745             


Glu Leu  Asn Pro Ser Ile Pro  Leu Leu Pro Asp Asp  Ile Leu Ser 
    2750                 2755                 2760             


Gln Ile  Arg Lys Cys Lys Val  Thr His Asp Gly Ile  Leu Ala Arg 
    2765                 2770                 2775             


Gln Gln  Ser Val Glu Ser Leu  Ala Glu Glu Val Lys  Asp Lys Val 
    2780                 2785                 2790             


Pro Ser  Leu Thr Thr Tyr Glu  Gly Ser Asp Leu Asn  Asn Thr Leu 
    2795                 2800                 2805             


Glu Asp  Leu Arg Asn Gln Tyr  Gln Met Leu Val Leu  Lys Ser Thr 
    2810                 2815                 2820             


Gln Arg  Ser Gln Gln Leu Glu  Phe Lys Leu Glu Glu  Arg Ser Asn 
    2825                 2830                 2835             


Phe Phe  Ala Ile Ile Arg Lys  Phe Gln Leu Met Val  Gln Glu Ser 
    2840                 2845                 2850             


Glu Thr  Leu Ile Ile Pro Arg  Val Glu Thr Ala Ala  Thr Glu Ala 
    2855                 2860                 2865             


Glu Leu  Lys His His His Val  Thr Leu Glu Ala Ser  Gln Lys Glu 
    2870                 2875                 2880             


Leu Gln  Glu Ile Asp Ser Gly  Ile Ser Thr His Leu  Gln Glu Leu 
    2885                 2890                 2895             


Thr Asn  Ile Tyr Glu Glu Leu  Asn Val Phe Glu Arg  Leu Phe Leu 
    2900                 2905                 2910             


Glu Asp  Gln Leu Lys Asn Leu  Lys Ile Arg Thr Asn  Arg Ile Gln 
    2915                 2920                 2925             


Arg Phe  Ile Gln Asn Thr Cys  Asn Glu Val Glu His  Lys Ile Lys 
    2930                 2935                 2940             


Phe Cys  Arg Gln Phe His Glu  Lys Thr Ser Ala Leu  Gln Glu Glu 
    2945                 2950                 2955             


Ala Asp  Ser Ile Gln Arg Asn  Glu Leu Leu Leu Asn  Gln Glu Val 
    2960                 2965                 2970             


Asn Lys  Gly Val Lys Glu Glu  Ile Tyr Asn Leu Lys  Asp Arg Leu 
    2975                 2980                 2985             


Thr Ala  Ile Lys Cys Cys Ile  Leu Gln Val Leu Lys  Leu Lys Lys 
    2990                 2995                 3000             


Val Phe  Asp Tyr Ile Gly Leu  Asn Trp Asp Phe Ser  Gln Leu Asp 
    3005                 3010                 3015             


Gln Leu  Gln Thr Gln Val Phe  Glu Lys Glu Lys Glu  Leu Glu Glu 
    3020                 3025                 3030             


Lys Ile  Lys Gln Leu Asp Thr  Phe Glu Glu Glu His  Gly Lys Tyr 
    3035                 3040                 3045             


Gln Ala  Leu Leu Ser Lys Met  Arg Ala Ile Asp Leu  Gln Ile Lys 
    3050                 3055                 3060             


Lys Met  Thr Glu Val Val Leu  Lys Ala Pro Asp Ser  Ser Pro Glu 
    3065                 3070                 3075             


Ser Arg  Arg Leu Asn Ala Gln  Ile Leu Ser Gln Arg  Ile Glu Lys 
    3080                 3085                 3090             


Ala Lys  Cys Leu Cys Asp Glu  Ile Ile Lys Lys Leu  Asn Glu Asn 
    3095                 3100                 3105             


Lys Thr  Phe Asp Asp Ser Phe  Lys Glu Lys Glu Ile  Leu Gln Ile 
    3110                 3115                 3120             


Lys Leu  Asn Ala Glu Glu Asn  Asp Lys Leu Tyr Lys  Val Leu Gln 
    3125                 3130                 3135             


Asn Met  Val Leu Glu Leu Ser  Pro Lys Glu Leu Asp  Glu Lys Asn 
    3140                 3145                 3150             


Cys Gln  Asp Lys Leu Glu Thr  Ser Leu His Val Leu  Asn Gln Ile 
    3155                 3160                 3165             


Lys Ser  Gln Leu Gln Gln Pro  Leu Leu Ile Asn Leu  Glu Ile Lys 
    3170                 3175                 3180             


His Ile  Gln Asn Glu Lys Asp  Asn Cys Glu Ala Phe  Gln Glu Gln 
    3185                 3190                 3195             


Val Trp  Ala Glu Met Cys Ser  Ile Lys Ala Val Thr  Ala Ile Glu 
    3200                 3205                 3210             


Lys Gln  Arg Glu Glu Asn Ser  Ser Glu Ala Ser Asp  Val Glu Thr 
    3215                 3220                 3225             


Lys Leu  Arg Glu Phe Glu Asp  Leu Gln Met Gln Leu  Asn Thr Ser 
    3230                 3235                 3240             


Ile Asp  Leu Arg Thr Asn Val  Leu Asn Asp Ala Tyr  Glu Asn Leu 
    3245                 3250                 3255             


Thr Arg  Tyr Lys Glu Ala Val  Thr Arg Ala Val Glu  Ser Ile Thr 
    3260                 3265                 3270             


Ser Leu  Glu Ala Ile Ile Ile  Pro Tyr Arg Val Asp  Val Gly Asn 
    3275                 3280                 3285             


Pro Glu  Glu Ser Leu Glu Met  Pro Leu Arg Lys Gln  Glu Glu Leu 
    3290                 3295                 3300             


Glu Ser  Thr Val Ala His Ile  Gln Asp Leu Thr Glu  Lys Leu Gly 
    3305                 3310                 3315             


Met Ile  Ser Ser Pro Glu Ala  Lys Leu Gln Leu Gln  Tyr Thr Leu 
    3320                 3325                 3330             


Gln Glu  Leu Val Ser Lys Asn  Ser Ala Met Lys Glu  Ala Phe Lys 
    3335                 3340                 3345             


Ala Gln  Glu Thr Glu Ala Glu  Arg Tyr Leu Glu Asn  Tyr Lys Cys 
    3350                 3355                 3360             


Tyr Arg  Lys Met Glu Glu Asp  Ile Tyr Thr Asn Leu  Ser Lys Met 
    3365                 3370                 3375             


Glu Thr  Val Leu Gly Gln Ser  Met Ser Ser Leu Pro  Leu Ser Tyr 
    3380                 3385                 3390             


Arg Glu  Ala Leu Glu Arg Leu  Glu Gln Ser Lys Ala  Leu Val Ser 
    3395                 3400                 3405             


Asn Leu  Ile Ser Thr Lys Glu  Glu Leu Met Lys Leu  Arg Gln Ile 
    3410                 3415                 3420             


Leu Arg  Leu Leu Arg Leu Arg  Cys Thr Glu Asn Asp  Gly Ile Cys 
    3425                 3430                 3435             


Leu Leu  Lys Ile Val Ser Ala  Leu Trp Glu Lys Trp  Leu Ser Leu 
    3440                 3445                 3450             


Leu Glu  Ala Ala Lys Glu Trp  Glu Met Trp Cys Glu  Glu Leu Lys 
    3455                 3460                 3465             


Gln Glu  Trp Lys Phe Val Ser  Glu Glu Ile Glu Arg  Glu Ala Ile 
    3470                 3475                 3480             


Ile Leu  Asp Asn Leu Gln Glu  Glu Leu Pro Glu Ile  Ser Lys Thr 
    3485                 3490                 3495             


Lys Glu  Ala Ala Thr Thr Glu  Glu Leu Ser Glu Leu  Leu Asp Cys 
    3500                 3505                 3510             


Leu Cys  Gln Tyr Gly Glu Asn  Val Glu Lys Gln Gln  Leu Leu Leu 
    3515                 3520                 3525             


Thr Leu  Leu Leu Gln Arg Ile  Arg Ser Ile Gln Asn  Val Pro Glu 
    3530                 3535                 3540             


Ser Ser  Gly Ala Val Glu Thr  Val Pro Ala Phe Gln  Glu Ile Thr 
    3545                 3550                 3555             


Ser Met  Lys Glu Arg Cys Asn  Lys Leu Leu Gln Lys  Val Gln Lys 
    3560                 3565                 3570             


Asn Lys  Glu Leu Val Gln Thr  Glu Ile Gln Glu Arg  His Ser Phe 
    3575                 3580                 3585             


Thr Lys  Glu Ile Ile Ala Leu  Lys Asn Phe Phe Gln  Gln Thr Thr 
    3590                 3595                 3600             


Thr Ser  Phe Gln Asn Met Ala  Phe Gln Asp His Pro  Glu Lys Ser 
    3605                 3610                 3615             


Glu Gln  Phe Glu Glu Leu Gln  Ser Ile Leu Lys Lys  Gly Lys Leu 
    3620                 3625                 3630             


Thr Phe  Glu Asn Ile Met Glu  Lys Leu Arg Ile Lys  Tyr Ser Glu 
    3635                 3640                 3645             


Met Tyr  Thr Ile Val Pro Ala  Glu Ile Glu Ser Gln  Val Glu Glu 
    3650                 3655                 3660             


Cys Arg  Lys Ala Leu Glu Asp  Ile Asp Glu Lys Ile  Ser Asn Glu 
    3665                 3670                 3675             


Val Leu  Lys Ser Ser Pro Ser  Tyr Ala Met Arg Arg  Lys Ile Glu 
    3680                 3685                 3690             


Glu Ile  Asn Asn Gly Leu His  Asn Val Glu Lys Met  Leu Gln Gln 
    3695                 3700                 3705             


Lys Ser  Lys Asn Ile Glu Lys  Ala Gln Glu Ile Gln  Lys Lys Met 
    3710                 3715                 3720             


Trp Asp  Glu Leu Asp Leu Trp  His Ser Lys Leu Asn  Glu Leu Asp 
    3725                 3730                 3735             


Ser Glu  Val Gln Asp Ile Val  Glu Gln Asp Pro Gly  Gln Ala Gln 
    3740                 3745                 3750             


Glu Trp  Met Asp Asn Leu Met  Ile Pro Phe Gln Gln  Tyr Gln Gln 
    3755                 3760                 3765             


Val Ser  Gln Arg Ala Glu Cys  Arg Thr Ser Gln Leu  Asn Lys Ala 
    3770                 3775                 3780             


Thr Val  Lys Met Glu Glu Tyr  Ser Asp Leu Leu Lys  Ser Thr Glu 
    3785                 3790                 3795             


Ala Trp  Ile Glu Asn Thr Ser  His Leu Leu Ala Asn  Pro Ala Asp 
    3800                 3805                 3810             


Tyr Asp  Ser Leu Arg Thr Leu  Ser His His Ala Ser  Thr Val Gln 
    3815                 3820                 3825             


Met Ala  Leu Glu Asp Ser Glu  Gln Lys His Asn Leu  Leu His Ser 
    3830                 3835                 3840             


Ile Phe  Met Asp Leu Glu Asp  Leu Ser Ile Ile Phe  Glu Thr Asp 
    3845                 3850                 3855             


Glu Leu  Thr Gln Ser Ile Gln  Glu Leu Ser Asn Gln  Val Thr Ala 
    3860                 3865                 3870             


Leu Gln  Gln Lys Ile Met Glu  Ser Leu Pro Gln Ile  Gln Arg Met 
    3875                 3880                 3885             


Ala Asp  Asp Val Val Ala Ile  Glu Ser Glu Val Lys  Ser Met Glu 
    3890                 3895                 3900             


Lys Arg  Val Ser Lys Ile Lys  Thr Ile Leu Leu Ser  Lys Glu Ile 
    3905                 3910                 3915             


Phe Asp  Phe Ser Pro Glu Glu  His Leu Lys His Gly  Glu Val Ile 
    3920                 3925                 3930             


Leu Glu  Asn Ile Arg Pro Met  Lys Lys Thr Ile Ala  Glu Ile Val 
    3935                 3940                 3945             


Ser Tyr  Gln Val Glu Leu Arg  Leu Pro Gln Thr Gly  Met Lys Pro 
    3950                 3955                 3960             


Leu Pro  Val Phe Gln Arg Thr  Asn Gln Leu Leu Gln  Asp Ile Lys 
    3965                 3970                 3975             


Leu Leu  Glu Asn Val Thr Gln  Glu Gln Asn Glu Leu  Leu Lys Val 
    3980                 3985                 3990             


Val Ile  Lys Gln Thr Asn Glu  Trp Asp Glu Glu Ile  Glu Asn Leu 
    3995                 4000                 4005             


Lys Gln  Ile Leu Asn Asn Tyr  Ser Ala Gln Phe Ser  Leu Glu His 
    4010                 4015                 4020             


Met Ser  Pro Asp Gln Ala Asp  Lys Leu Pro Gln Leu  Gln Gly Glu 
    4025                 4030                 4035             


Ile Glu  Arg Met Glu Lys Gln  Ile Leu Ser Leu Asn  Gln Arg Lys 
    4040                 4045                 4050             


Glu Asp  Leu Leu Val Asp Leu  Lys Ala Thr Val Leu  Asn Leu His 
    4055                 4060                 4065             


Gln His  Leu Lys Gln Glu Gln  Glu Gly Val Glu Arg  Asp Arg Leu 
    4070                 4075                 4080             


Pro Ala  Val Thr Ser Glu Glu  Gly Gly Val Ala Glu  Arg Asp Ala 
    4085                 4090                 4095             


Ser Glu  Arg Lys Leu Asn Arg  Arg Gly Ser Met Ser  Tyr Leu Ala 
    4100                 4105                 4110             


Ala Val  Glu Glu Glu Val Glu  Glu Ser Ser Val Lys  Ser Asp Asn 
    4115                 4120                 4125             


Gly Asp  Glu Lys Ala Glu Pro  Ser Pro Gln Ser Trp  Ser Ser Leu 
    4130                 4135                 4140             


Trp Lys  His Asp Lys Asp Met  Glu Glu Asp Arg Ala  Ser Ser Ser 
    4145                 4150                 4155             


Ser Gly  Thr Ile Val Gln Glu  Ala Tyr Gly Lys Ile  Ser Thr Ser 
    4160                 4165                 4170             


Asp Asn  Ser Met Ala Gln Ile  Leu Thr Pro Asp Ser  Leu Asn Thr 
    4175                 4180                 4185             


Glu Gln  Gly Pro Glu Cys Ser  Leu Arg Pro Asn Gln  Thr Glu Glu 
    4190                 4195                 4200             


Gly Thr  Thr Pro Pro Ile Glu  Ala Asp Thr Leu Asp  Ser Ser Asp 
    4205                 4210                 4215             


Ala Gln  Gly Gly Leu Glu Pro  Arg Val Glu Lys Thr  Arg Pro Glu 
    4220                 4225                 4230             


Pro Thr  Glu Val Leu His Ala  Cys Lys Thr Gln Val  Ala Glu Leu 
    4235                 4240                 4245             


Glu Leu  Trp Leu Gln Gln Ala  Asn Val Ala Val Glu  Pro Glu Thr 
    4250                 4255                 4260             


Leu Asn  Ala Asp Met Gln Gln  Val Leu Glu Gln Gln  Leu Val Gly 
    4265                 4270                 4275             


Cys Gln  Ala Met Leu Thr Glu  Ile Glu His Lys Val  Ala Phe Leu 
    4280                 4285                 4290             


Leu Glu  Thr Cys Lys Asp Gln  Gly Leu Gly Asp Asn  Gly Ala Thr 
    4295                 4300                 4305             


Gln His  Glu Ala Glu Ala Leu  Ser Leu Lys Leu Lys  Thr Val Lys 
    4310                 4315                 4320             


Cys Asn  Leu Glu Lys Val Gln  Met Met Leu Gln Glu  Lys His Ser 
    4325                 4330                 4335             


Glu Asp  Gln His Pro Thr Ile  Leu Lys Lys Ser Ser  Glu Pro Glu 
    4340                 4345                 4350             


His Gln  Glu Ala Leu Gln Pro  Val Asn Leu Ser Glu  Leu Glu Ser 
    4355                 4360                 4365             


Ile Val  Thr Glu Arg Pro Gln  Phe Ser Arg Gln Lys  Asp Phe Gln 
    4370                 4375                 4380             


Gln Gln  Gln Val Leu Glu Leu  Lys Pro Met Glu Gln  Lys Asp Phe 
    4385                 4390                 4395             


Ile Lys  Phe Ile Glu Phe Asn  Ala Lys Lys Met Trp  Pro Gln Tyr 
    4400                 4405                 4410             


Cys Gln  His Asp Asn Asp Thr  Thr Gln Glu Ser Ser  Ala Ser Asn 
    4415                 4420                 4425             


Gln Ala  Ser Ser Pro Glu Asn  Asp Val Pro Asp Ser  Ile Leu Ser 
    4430                 4435                 4440             


Pro Gln  Gly Gln Asn Gly Asp  Lys Trp Gln Tyr Leu  His His Glu 
    4445                 4450                 4455             


Leu Ser  Ser Lys Ile Lys Leu  Pro Leu Pro Gln Leu  Val Glu Pro 
    4460                 4465                 4470             


Gln Val  Ser Thr Asn Met Gly  Ile Leu Pro Ser Val  Thr Met Tyr 
    4475                 4480                 4485             


Asn Phe  Arg Tyr Pro Thr Thr  Glu Glu Leu Lys Thr  Tyr Thr Thr 
    4490                 4495                 4500             


Gln Leu  Glu Asp Leu Arg Gln  Glu Ala Ser Asn Leu  Gln Thr Gln 
    4505                 4510                 4515             


Glu Asn  Met Thr Glu Glu Ala  Tyr Ile Asn Leu Asp  Lys Lys Leu 
    4520                 4525                 4530             


Phe Glu  Leu Phe Leu Thr Leu  Ser Gln Cys Leu Ser  Ser Val Glu 
    4535                 4540                 4545             


Glu Met  Leu Glu Met Pro Arg  Leu Tyr Arg Glu Asp  Gly Ser Gly 
    4550                 4555                 4560             


Gln Gln  Val His Tyr Glu Thr  Leu Ala Leu Glu Leu  Lys Lys Leu 
    4565                 4570                 4575             


Tyr Leu  Ala Leu Ser Asp Lys  Lys Gly Asp Leu Leu  Lys Ala Met 
    4580                 4585                 4590             


Thr Trp  Pro Gly Glu Asn Thr  Asn Leu Leu Leu Glu  Cys Phe Asp 
    4595                 4600                 4605             


Asn Leu  Gln Val Cys Leu Glu  His Thr Gln Ala Ala  Ala Val Cys 
    4610                 4615                 4620             


Arg Ser  Lys Ser Leu Lys Ala  Gly Leu Asp Tyr Asn  Arg Ser Tyr 
    4625                 4630                 4635             


Gln Asn  Glu Ile Lys Arg Leu  Tyr His Gln Leu Ile  Lys Ser Lys 
    4640                 4645                 4650             


Thr Ser  Leu Gln Gln Ser Leu  Asn Glu Ile Ser Gly  Gln Ser Val 
    4655                 4660                 4665             


Ala Glu  Gln Leu Gln Lys Ala  Asp Ala Tyr Thr Val  Glu Leu Glu 
    4670                 4675                 4680             


Asn Ala  Glu Ser Arg Val Ala  Lys Leu Arg Asp Glu  Gly Glu Arg 
    4685                 4690                 4695             


Leu His  Leu Pro Tyr Ala Leu  Leu Gln Glu Val Tyr  Lys Leu Glu 
    4700                 4705                 4710             


Asp Val  Leu Asp Ser Met Trp  Gly Met Leu Arg Ala  Arg Tyr Thr 
    4715                 4720                 4725             


Glu Leu  Ser Ser Pro Phe Val  Thr Glu Ser Gln Gln  Asp Ala Leu 
    4730                 4735                 4740             


Leu Gln  Gly Met Val Glu Leu  Val Lys Ile Gly Lys  Glu Lys Leu 
    4745                 4750                 4755             


Ala His  Gly His Leu Lys Gln  Thr Lys Ser Lys Val  Ala Leu Gln 
    4760                 4765                 4770             


Ala Gln  Ile Glu Asn His Lys  Val Phe Phe Gln Lys  Leu Val Ala 
    4775                 4780                 4785             


Asp Met  Leu Leu Ile Gln Ala  Tyr Ser Ala Lys Ile  Leu Pro Ser 
    4790                 4795                 4800             


Leu Leu  Gln Asn Arg Glu Thr  Phe Trp Ala Glu Gln  Val Thr Glu 
    4805                 4810                 4815             


Val Lys  Ile Leu Glu Glu Lys  Ser Arg Gln Cys Gly  Met Lys Leu 
    4820                 4825                 4830             


Gln Ser  Leu Leu Gln Lys Trp  Glu Glu Phe Asp Glu  Asn Tyr Ala 
    4835                 4840                 4845             


Ser Leu  Glu Lys Asp Leu Glu  Ile Leu Ile Ser Thr  Leu Pro Ser 
    4850                 4855                 4860             


Val Ser  Leu Val Glu Glu Thr  Glu Glu Arg Leu Val  Glu Arg Ile 
    4865                 4870                 4875             


Ser Phe  Tyr Gln Gln Ile Lys  Arg Asn Ile Gly Gly  Lys His Ala 
    4880                 4885                 4890             


Arg Leu  Tyr Gln Thr Leu Asn  Glu Gly Lys Gln Leu  Val Ala Ser 
    4895                 4900                 4905             


Val Ser  Cys Pro Glu Leu Glu  Gly Gln Ile Ala Lys  Leu Glu Glu 
    4910                 4915                 4920             


Gln Trp  Leu Ser Leu Asn Lys  Lys Ile Asp His Glu  Leu His Arg 
    4925                 4930                 4935             


Leu Gln  Ala Leu Leu Lys His  Leu Leu Ser Tyr Asn  Arg Asp Ser 
    4940                 4945                 4950             


Asp Gln  Leu Thr Lys Trp Leu  Glu Ser Ser Gln His  Thr Leu Asn 
    4955                 4960                 4965             


Tyr Trp  Lys Glu Gln Ser Leu  Asn Val Ser Gln Asp  Leu Asp Thr 
    4970                 4975                 4980             


Ile Arg  Ser Asn Ile Asn Asn  Phe Phe Glu Phe Ser  Lys Glu Val 
    4985                 4990                 4995             


Asp Glu  Lys Ser Ser Leu Lys  Thr Ala Val Ile Ser  Ile Gly Asn 
    5000                 5005                 5010             


Gln Leu  Leu His Leu Lys Glu  Thr Asp Thr Ala Thr  Leu Arg Ala 
    5015                 5020                 5025             


Ser Leu  Ala Gln Phe Glu Gln  Lys Trp Thr Met Leu  Ile Thr Gln 
    5030                 5035                 5040             


Leu Pro  Asp Ile Gln Glu Lys  Leu His Gln Leu Gln  Met Glu Lys 
    5045                 5050                 5055             


Leu Pro  Ser Arg Lys Ala Ile  Thr Glu Met Ile Ser  Trp Met Asn 
    5060                 5065                 5070             


Asn Val  Glu His Gln Thr Ser  Asp Glu Asp Ser Val  His Ser Pro 
    5075                 5080                 5085             


Ser Ser  Ala Ser Gln Val Lys  His Leu Leu Gln Lys  His Lys Glu 
    5090                 5095                 5100             


Phe Arg  Met Glu Met Asp Tyr  Lys Gln Trp Ile Val  Asp Phe Val 
    5105                 5110                 5115             


Asn Gln  Ser Leu Leu Gln Leu  Ser Thr Cys Asp Val  Glu Ser Lys 
    5120                 5125                 5130             


Arg Tyr  Glu Arg Thr Glu Phe  Ala Glu His Leu Gly  Glu Met Asn 
    5135                 5140                 5145             


Arg Gln  Trp His Arg Val His  Gly Met Leu Asn Arg  Lys Ile Gln 
    5150                 5155                 5160             


His Leu  Glu Gln Leu Leu Glu  Ser Ile Thr Glu Ser  Glu Asn Lys 
    5165                 5170                 5175             


Ile Gln  Ile Leu Asn Asn Trp  Leu Glu Ala Gln Glu  Glu Arg Leu 
    5180                 5185                 5190             


Lys Thr  Leu Gln Lys Pro Glu  Ser Val Ile Ser Val  Gln Lys Leu 
    5195                 5200                 5205             


Leu Leu  Asp Cys Gln Asp Ile  Glu Asn Gln Leu Ala  Ile Lys Ser 
    5210                 5215                 5220             


Lys Ala  Leu Asp Glu Leu Lys  Gln Ser Tyr Leu Thr  Leu Glu Ser 
    5225                 5230                 5235             


Gly Ala  Val Pro Leu Leu Glu  Asp Thr Ala Ser Arg  Ile Asp Glu 
    5240                 5245                 5250             


Leu Phe  Gln Lys Arg Ser Ser  Val Leu Thr Gln Val  Asn Gln Leu 
    5255                 5260                 5265             


Lys Thr  Ser Met Gln Ser Val  Leu Gln Glu Trp Lys  Ile Tyr Asp 
    5270                 5275                 5280             


Gln Leu  Tyr Asp Glu Val Asn  Met Met Thr Ile Arg  Phe Trp Tyr 
    5285                 5290                 5295             


Cys Met  Glu His Ser Lys Pro  Val Val Leu Ser Leu  Glu Thr Leu 
    5300                 5305                 5310             


Arg Cys  Gln Val Glu Asn Leu  Gln Ser Leu Gln Asp  Glu Ala Glu 
    5315                 5320                 5325             


Ser Ser  Glu Gly Ser Trp Glu  Lys Leu Gln Glu Val  Ile Gly Lys 
    5330                 5335                 5340             


Leu Lys  Gly Leu Cys Pro Ser  Val Ala Glu Ile Ile  Glu Glu Lys 
    5345                 5350                 5355             


Cys Gln  Asn Thr His Lys Arg  Trp Thr Gln Val Asn  Gln Ala Ile 
    5360                 5365                 5370             


Ala Asp  Gln Leu Gln Lys Ala  Gln Ser Leu Leu Gln  Leu Trp Lys 
    5375                 5380                 5385             


Ala Tyr  Ser Asn Ala His Gly  Glu Ala Ala Ala Arg  Leu Lys Gln 
    5390                 5395                 5400             


Gln Glu  Ala Lys Phe Gln Gln  Leu Ala Asn Ile Ser  Met Ser Gly 
    5405                 5410                 5415             


Asn Asn  Leu Ala Glu Ile Leu  Pro Pro Ala Leu Gln  Asp Ile Lys 
    5420                 5425                 5430             


Glu Leu  Gln His Asp Val Gln  Lys Thr Lys Glu Ala  Phe Leu Gln 
    5435                 5440                 5445             


Asn Ser  Ser Val Leu Asp Arg  Leu Pro Gln Pro Ala  Glu Ser Ser 
    5450                 5455                 5460             


Thr His  Met Leu Leu Pro Gly  Pro Leu His Ser Leu  Gln Arg Ala 
    5465                 5470                 5475             


Ala Tyr  Leu Glu Lys Met Leu  Leu Val Lys Ala Asn  Glu Phe Glu 
    5480                 5485                 5490             


Phe Val  Leu Ser Gln Phe Lys  Asp Phe Gly Val Arg  Leu Glu Ser 
    5495                 5500                 5505             


Leu Lys  Gly Leu Ile Met His  Glu Glu Glu Asn Leu  Asp Arg Leu 
    5510                 5515                 5520             


His Gln  Gln Glu Lys Glu Asn  Pro Asp Ser Phe Leu  Asn His Val 
    5525                 5530                 5535             


Leu Ala  Leu Thr Ala Gln Ser  Pro Asp Ile Glu His  Leu Asn Glu 
    5540                 5545                 5550             


Val Ser  Leu Lys Leu Pro Leu  Ser Asp Val Ala Val  Lys Thr Leu 
    5555                 5560                 5565             


Gln Asn  Met Asn Arg Gln Trp  Ile Arg Ala Thr Ala  Thr Ala Leu 
    5570                 5575                 5580             


Glu Arg  Cys Ser Glu Leu Gln  Gly Ile Gly Leu Asn  Glu Lys Phe 
    5585                 5590                 5595             


Leu Tyr  Cys Cys Glu Lys Trp  Ile Gln Leu Leu Glu  Lys Ile Glu 
    5600                 5605                 5610             


Glu Ala  Leu Lys Val Asp Val  Ala Asn Ser Leu Pro  Glu Leu Leu 
    5615                 5620                 5625             


Glu Gln  Gln Lys Thr Tyr Lys  Met Leu Glu Ala Glu  Val Ser Ile 
    5630                 5635                 5640             


Asn Gln  Thr Ile Ala Asp Ser  Tyr Val Thr Gln Ser  Leu Gln Leu 
    5645                 5650                 5655             


Leu Asp  Thr Thr Glu Ile Glu  Asn Arg Pro Glu Phe  Ile Thr Glu 
    5660                 5665                 5670             


Phe Ser  Lys Leu Thr Asp Arg  Trp Gln Asn Ala Val  Gln Gly Val 
    5675                 5680                 5685             


Arg Gln  Arg Lys Gly Asp Val  Asp Gly Leu Val Arg  Gln Trp Gln 
    5690                 5695                 5700             


Asp Phe  Thr Thr Ser Val Glu  Asn Leu Phe Arg Phe  Leu Thr Asp 
    5705                 5710                 5715             


Thr Ser  His Leu Leu Ser Ala  Val Lys Gly Gln Glu  Arg Phe Ser 
    5720                 5725                 5730             


Leu Tyr  Gln Thr Arg Ser Leu  Ile His Glu Leu Lys  Asn Lys Glu 
    5735                 5740                 5745             


Ile His  Phe Gln Arg Arg Arg  Thr Thr Cys Ala Leu  Thr Leu Glu 
    5750                 5755                 5760             


Ala Gly  Glu Lys Leu Leu Leu  Thr Thr Asp Leu Lys  Thr Lys Glu 
    5765                 5770                 5775             


Ser Val  Gly Arg Arg Ile Ser  Gln Leu Gln Asp Ser  Trp Lys Asp 
    5780                 5785                 5790             


Met Glu  Pro Gln Leu Ala Glu  Met Ile Lys Gln Phe  Gln Ser Thr 
    5795                 5800                 5805             


Val Glu  Thr Trp Asp Gln Cys  Glu Lys Lys Ile Lys  Glu Leu Lys 
    5810                 5815                 5820             


Ser Arg  Leu Gln Val Leu Lys  Ala Gln Ser Glu Asp  Pro Leu Pro 
    5825                 5830                 5835             


Glu Leu  His Glu Asp Leu His  Asn Glu Lys Glu Leu  Ile Lys Glu 
    5840                 5845                 5850             


Leu Glu  Gln Ser Leu Ala Ser  Trp Thr Gln Asn Leu  Lys Glu Leu 
    5855                 5860                 5865             


Gln Thr  Met Lys Ala Asp Leu  Thr Arg His Val Leu  Val Glu Asp 
    5870                 5875                 5880             


Val Met  Val Leu Lys Glu Gln  Ile Glu His Leu His  Arg Gln Trp 
    5885                 5890                 5895             


Glu Asp  Leu Cys Leu Arg Val  Ala Ile Arg Lys Gln  Glu Ile Glu 
    5900                 5905                 5910             


Asp Arg  Leu Asn Thr Trp Val  Val Phe Asn Glu Lys  Asn Lys Glu 
    5915                 5920                 5925             


Leu Cys  Ala Trp Leu Val Gln  Met Glu Asn Lys Val  Leu Gln Thr 
    5930                 5935                 5940             


Ala Asp  Ile Ser Ile Glu Glu  Met Ile Glu Lys Leu  Gln Lys Asp 
    5945                 5950                 5955             


Cys Met  Glu Glu Ile Asn Leu  Phe Ser Glu Asn Lys  Leu Gln Leu 
    5960                 5965                 5970             


Lys Gln  Met Gly Asp Gln Leu  Ile Lys Ala Ser Asn  Lys Ser Arg 
    5975                 5980                 5985             


Ala Ala  Glu Ile Asp Asp Lys  Leu Asn Lys Ile Asn  Asp Arg Trp 
    5990                 5995                 6000             


Gln His  Leu Phe Asp Val Ile  Gly Ser Arg Val Lys  Lys Leu Lys 
    6005                 6010                 6015             


Glu Thr  Phe Ala Phe Ile Gln  Gln Leu Asp Lys Asn  Met Ser Asn 
    6020                 6025                 6030             


Leu Arg  Thr Trp Leu Ala Arg  Ile Glu Ser Glu Leu  Ser Lys Pro 
    6035                 6040                 6045             


Val Val  Tyr Asp Val Cys Asp  Asp Gln Glu Ile Gln  Lys Arg Leu 
    6050                 6055                 6060             


Ala Glu  Gln Gln Asp Leu Gln  Arg Asp Ile Glu Gln  His Ser Ala 
    6065                 6070                 6075             


Gly Val  Glu Ser Val Phe Asn  Ile Cys Asp Val Leu  Leu His Asp 
    6080                 6085                 6090             


Ser Asp  Ala Cys Ala Asn Glu  Thr Glu Cys Asp Ser  Ile Gln Gln 
    6095                 6100                 6105             


Thr Thr  Arg Ser Leu Asp Arg  Arg Trp Arg Asn Ile  Cys Ala Met 
    6110                 6115                 6120             


Ser Met  Glu Arg Arg Met Lys  Ile Glu Glu Thr Trp  Arg Leu Trp 
    6125                 6130                 6135             


Gln Lys  Phe Leu Asp Asp Tyr  Ser Arg Phe Glu Asp  Trp Leu Lys 
    6140                 6145                 6150             


Ser Ala  Glu Arg Thr Ala Ala  Cys Pro Asn Ser Ser  Glu Val Leu 
    6155                 6160                 6165             


Tyr Thr  Ser Ala Lys Glu Glu  Leu Lys Arg Phe Glu  Ala Phe Gln 
    6170                 6175                 6180             


Arg Gln  Ile His Glu Arg Leu  Thr Gln Leu Glu Leu  Ile Asn Lys 
    6185                 6190                 6195             


Gln Tyr  Arg Arg Leu Ala Arg  Glu Asn Arg Thr Asp  Thr Ala Ser 
    6200                 6205                 6210             


Arg Leu  Lys Gln Met Val His  Glu Gly Asn Gln Arg  Trp Asp Asn 
    6215                 6220                 6225             


Leu Gln  Arg Arg Val Thr Ala  Val Leu Arg Arg Leu  Arg His Phe 
    6230                 6235                 6240             


Thr Asn  Gln Arg Glu Glu Phe  Glu Gly Thr Arg Glu  Ser Ile Leu 
    6245                 6250                 6255             


Val Trp  Leu Thr Glu Met Asp  Leu Gln Leu Thr Asn  Val Glu His 
    6260                 6265                 6270             


Phe Ser  Glu Ser Asp Ala Asp  Asp Lys Met Arg Gln  Leu Asn Gly 
    6275                 6280                 6285             


Phe Gln  Gln Glu Ile Thr Leu  Asn Thr Asn Lys Ile  Asp Gln Leu 
    6290                 6295                 6300             


Ile Val  Phe Gly Glu Gln Leu  Ile Gln Lys Ser Glu  Pro Leu Asp 
    6305                 6310                 6315             


Ala Val  Leu Ile Glu Asp Glu  Leu Glu Glu Leu His  Arg Tyr Cys 
    6320                 6325                 6330             


Gln Glu  Val Phe Gly Arg Val  Ser Arg Phe His Arg  Arg Leu Thr 
    6335                 6340                 6345             


Ser Cys  Thr Pro Gly Leu Glu  Asp Glu Lys Glu Ala  Ser Glu Asn 
    6350                 6355                 6360             


Glu Thr  Asp Met Glu Asp Pro  Arg Glu Ile Gln Thr  Asp Ser Trp 
    6365                 6370                 6375             


Arg Lys  Arg Gly Glu Ser Glu  Glu Pro Ser Ser Pro  Gln Ser Leu 
    6380                 6385                 6390             


Cys His  Leu Val Ala Pro Gly  His Glu Arg Ser Gly  Cys Glu Thr 
    6395                 6400                 6405             


Pro Val  Ser Val Asp Ser Ile  Pro Leu Glu Trp Asp  His Thr Gly 
    6410                 6415                 6420             


Asp Val  Gly Gly Ser Ser Ser  His Glu Glu Asp Glu  Glu Gly Pro 
    6425                 6430                 6435             


Tyr Tyr  Ser Ala Leu Ser Gly  Lys Ser Ile Ser Asp  Gly His Ser 
    6440                 6445                 6450             


Trp His  Val Pro Asp Ser Pro  Ser Cys Pro Glu His  His Tyr Lys 
    6455                 6460                 6465             


Gln Met  Glu Gly Asp Arg Asn  Val Pro Pro Val Pro  Pro Ala Ser 
    6470                 6475                 6480             


Ser Thr  Pro Tyr Lys Pro Pro  Tyr Gly Lys Leu Leu  Leu Pro Pro 
    6485                 6490                 6495             


Gly Thr  Asp Gly Gly Lys Glu  Gly Pro Arg Val Leu  Asn Gly Asn 
    6500                 6505                 6510             


Pro Gln  Gln Glu Asp Gly Gly  Leu Ala Gly Ile Thr  Glu Gln Gln 
    6515                 6520                 6525             


Ser Gly  Ala Phe Asp Arg Trp  Glu Met Ile Gln Ala  Gln Glu Leu 
    6530                 6535                 6540             


His Asn  Lys Leu Lys Ile Lys  Gln Asn Leu Gln Gln  Leu Asn Ser 
    6545                 6550                 6555             


Asp Ile  Ser Ala Ile Thr Thr  Trp Leu Lys Lys Thr  Glu Ala Glu 
    6560                 6565                 6570             


Leu Glu  Met Leu Lys Met Ala  Lys Pro Pro Ser Asp  Ile Gln Glu 
    6575                 6580                 6585             


Ile Glu  Leu Arg Val Lys Arg  Leu Gln Glu Ile Leu  Lys Ala Phe 
    6590                 6595                 6600             


Asp Thr  Tyr Lys Ala Leu Val  Val Ser Val Asn Val  Ser Ser Lys 
    6605                 6610                 6615             


Glu Phe  Leu Gln Thr Glu Ser  Pro Glu Ser Thr Glu  Leu Gln Ser 
    6620                 6625                 6630             


Arg Leu  Arg Gln Leu Ser Leu  Leu Trp Glu Ala Ala  Gln Gly Ala 
    6635                 6640                 6645             


Val Asp  Ser Trp Arg Gly Gly  Leu Arg Gln Ser Leu  Met Gln Cys 
    6650                 6655                 6660             


Gln Asp  Phe His Gln Leu Ser  Gln Asn Leu Leu Leu  Trp Leu Ala 
    6665                 6670                 6675             


Ser Ala  Lys Asn Arg Arg Gln  Lys Ala His Val Thr  Asp Pro Lys 
    6680                 6685                 6690             


Ala Asp  Pro Arg Ala Leu Leu  Glu Cys Arg Arg Glu  Leu Met Gln 
    6695                 6700                 6705             


Leu Glu  Lys Glu Leu Val Glu  Arg Gln Pro Gln Val  Asp Met Leu 
    6710                 6715                 6720             


Gln Glu  Ile Ser Asn Ser Leu  Leu Ile Lys Gly His  Gly Glu Asp 
    6725                 6730                 6735             


Cys Ile  Glu Ala Glu Glu Lys  Val His Val Ile Glu  Lys Lys Leu 
    6740                 6745                 6750             


Lys Gln  Leu Arg Glu Gln Val  Ser Gln Asp Leu Met  Ala Leu Gln 
    6755                 6760                 6765             


Gly Thr  Gln Asn Pro Ala Ser  Pro Leu Pro Ser Phe  Asp Glu Val 
    6770                 6775                 6780             


Asp Ser  Gly Asp Gln Pro Pro  Ala Thr Ser Val Pro  Ala Pro Arg 
    6785                 6790                 6795             


Ala Lys  Gln Phe Arg Ala Val  Arg Thr Thr Glu Gly  Glu Glu Glu 
    6800                 6805                 6810             


Thr Glu  Ser Arg Val Pro Gly  Ser Thr Arg Pro Gln  Arg Ser Phe 
    6815                 6820                 6825             


Leu Ser  Arg Val Val Arg Ala  Ala Leu Pro Leu Gln  Leu Leu Leu 
    6830                 6835                 6840             


Leu Leu  Leu Leu Leu Leu Ala  Cys Leu Leu Pro Ser  Ser Glu Glu 
    6845                 6850                 6855             


Asp Tyr  Ser Cys Thr Gln Ala  Asn Asn Phe Ala Arg  Ser Phe Tyr 
    6860                 6865                 6870             


Pro Met  Leu Arg Tyr Thr Asn  Gly Pro Pro Pro Thr  
    6875                 6880                 6885 


<210>  345
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Thr Ser Phe Gln Glu Val Pro Leu Gln Thr Ser Asn Phe Ala His 
1               5                   10                  15      


Val Ile Phe Gln Asn Val Ala Lys Ser Tyr Leu Pro Asn Ala His Leu 
            20                  25                  30          


Glu Cys His Tyr Thr Leu Thr Pro Tyr Ile His Pro His Pro Lys Asp 
        35                  40                  45              


Trp Val Gly Ile Phe Lys Val Gly Trp Ser Thr Ala Arg Asp Tyr Tyr 
    50                  55                  60                  


Thr Phe Leu Trp Ser Pro Met Pro Glu His Tyr Val Glu Gly Ser Thr 
65                  70                  75                  80  


Val Asn Cys Val Leu Ala Phe Gln Gly Tyr Tyr Leu Pro Asn Asp Asp 
                85                  90                  95      


Gly Glu Phe Tyr Gln Phe Cys Tyr Val Thr His Lys Gly Glu Ile Arg 
            100                 105                 110         


Gly Ala Ser Thr Pro Phe Gln Phe Arg Ala Ser Ser Pro Val Glu Glu 
        115                 120                 125             


Leu Leu Thr Met Glu Asp Glu Gly Asn Ser Asp Met Leu Val Val Thr 
    130                 135                 140                 


Thr Lys Ala Gly Leu Leu Glu Leu Lys Ile Glu Lys Thr Met Lys Glu 
145                 150                 155                 160 


Lys Glu Glu Leu Leu Lys Leu Ile Ala Val Leu Glu Lys Glu Thr Ala 
                165                 170                 175     


Gln Leu Arg Glu Gln Val Gly Arg Met Glu Arg Glu Leu Asn His Glu 
            180                 185                 190         


Lys Glu Arg Cys Asp Gln Leu Gln Ala Glu Gln Lys Gly Leu Thr Glu 
        195                 200                 205             


Val Thr Gln Ser Leu Lys Met Glu Asn Glu Glu Phe Lys Lys Arg Phe 
    210                 215                 220                 


Ser Asp Ala Thr Ser Lys Ala His Gln Leu Glu Glu Asp Ile Val Ser 
225                 230                 235                 240 


Val Thr His Lys Ala Ile Glu Lys Glu Thr Glu Leu Asp Ser Leu Lys 
                245                 250                 255     


Asp Lys Leu Lys Lys Ala Gln His Glu Arg Glu Gln Leu Glu Cys Gln 
            260                 265                 270         


Leu Lys Thr Glu Lys Asp Glu Lys Glu Leu Tyr Lys Val His Leu Lys 
        275                 280                 285             


Asn Thr Glu Ile Glu Asn Thr Lys Leu Met Ser Glu Val Gln Thr Leu 
    290                 295                 300                 


Lys Asn Leu Asp Gly Asn Lys Glu Ser Val Ile Thr His Phe Lys Glu 
305                 310                 315                 320 


Glu Ile Gly Arg Leu Gln Leu Cys Leu Ala Glu Lys Glu Asn Leu Gln 
                325                 330                 335     


Arg Thr Phe Leu Leu Thr Thr Ser Ser Lys Glu Asp Thr Cys Phe Leu 
            340                 345                 350         


Lys Glu Gln Leu Arg Lys Ala Glu Glu Gln Val Gln Ala Thr Arg Gln 
        355                 360                 365             


Glu Val Val Phe Leu Ala Lys Glu Leu Ser Asp Ala Val Asn Val Arg 
    370                 375                 380                 


Asp Arg Thr Met Ala Asp Leu His Thr Ala Arg Leu Glu Asn Glu Lys 
385                 390                 395                 400 


Val Lys Lys Gln Leu Ala Asp Ala Val Ala Glu Leu Lys Leu Asn Ala 
                405                 410                 415     


Met Lys Lys Asp Gln Asp Lys Thr Asp Thr Leu Glu His Glu Leu Arg 
            420                 425                 430         


Arg Glu Val Glu Asp Leu Lys Leu Arg Leu Gln Met Ala Ala Asp His 
        435                 440                 445             


Tyr Lys Glu Lys Phe Lys Glu Cys Gln Arg Leu Gln Lys Gln Ile Asn 
    450                 455                 460                 


Lys Leu Ser Asp Gln Ser Ala Asn Asn Asn Asn Val Phe Thr Lys Lys 
465                 470                 475                 480 


Thr Gly Asn Gln Gln Lys Val Asn Asp Ala Ser Val Asn Thr Asp Pro 
                485                 490                 495     


Ala Thr Ser Ala Ser Thr Val Asp Val Lys Pro Ser Pro Ser Ala Ala 
            500                 505                 510         


Glu Ala Asp Phe Asp Ile Val Thr Lys Gly Gln Val Cys Glu Met Thr 
        515                 520                 525             


Lys Glu Ile Ala Asp Lys Thr Glu Lys Tyr Asn Lys Cys Lys Gln Leu 
    530                 535                 540                 


Leu Gln Asp Glu Lys Ala Lys Cys Asn Lys Tyr Ala Asp Glu Leu Ala 
545                 550                 555                 560 


Lys Met Glu Leu Lys Trp Lys Glu Gln Val Lys Ile Ala Glu Asn Val 
                565                 570                 575     


Lys Leu Glu Leu Ala Glu Val Gln Asp Asn Tyr Lys Glu Leu Lys Arg 
            580                 585                 590         


Ser Leu Glu Asn Pro Ala Glu Arg Lys Met Glu Gly Gln Asn Ser Gln 
        595                 600                 605             


Ser Pro Gln Cys Phe Lys Thr Cys Ser Glu Gln Asn Gly Tyr Val Leu 
    610                 615                 620                 


Thr Leu Ser Asn Ala Gln Pro Val Leu Gln Tyr Gly Asn Pro Tyr Ala 
625                 630                 635                 640 


Ser Gln Glu Thr Arg Asp Gly Ala Asp Gly Ala Phe Tyr Pro Asp Glu 
                645                 650                 655     


Ile Gln Arg Pro Pro Val Arg Val Pro Ser Trp Gly Leu Glu Asp Asn 
            660                 665                 670         


Val Val Cys Ser Gln Pro Ala Arg Asn Phe Ser Arg Pro Asp Gly Leu 
        675                 680                 685             


Glu Asp Ser Glu Asp Ser Lys Glu Asp Glu Asn Val Pro Thr Ala Pro 
    690                 695                 700                 


Asp Pro Pro Ser Gln His Leu Arg Gly His Gly Thr Gly Phe Cys Phe 
705                 710                 715                 720 


Asp Ser Ser Phe Asp Val His Lys Lys Cys Pro Leu Cys Glu Leu Met 
                725                 730                 735     


Phe Pro Pro Asn Tyr Asp Gln Ser Lys Phe Glu Glu His Val Glu Ser 
            740                 745                 750         


His Trp Lys Val Cys Pro Met Cys Ser Glu Gln Phe Pro Pro Asp Tyr 
        755                 760                 765             


Asp Gln Gln Val Phe Glu Arg His Val Gln Thr His Phe Asp Gln Asn 
    770                 775                 780                 


Val Leu Asn Phe Asp 
785                 


<210>  346
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  347
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Ala Thr Pro Leu Val Ala Gly Pro Ala Ala Leu Arg Phe Ala Ala 
1               5                   10                  15      


Ala Ala Ser Trp Gln Val Val Arg Gly Arg Cys Val Glu His Phe Pro 
            20                  25                  30          


Arg Val Leu Glu Phe Leu Arg Ser Leu Arg Ala Val Ala Pro Gly Leu 
        35                  40                  45              


Val Arg Tyr Arg His His Glu Arg Leu Cys Met Gly Leu Lys Ala Lys 
    50                  55                  60                  


Val Val Val Glu Leu Ile Leu Gln Gly Arg Pro Trp Ala Gln Val Leu 
65                  70                  75                  80  


Lys Ala Leu Asn His His Phe Pro Glu Ser Gly Pro Ile Val Arg Asp 
                85                  90                  95      


Pro Lys Ala Thr Lys Gln Asp Leu Arg Lys Ile Leu Glu Ala Gln Glu 
            100                 105                 110         


Thr Phe Tyr Gln Gln Val Lys Gln Leu Ser Glu Ala Pro Val Asp Leu 
        115                 120                 125             


Ala Ser Lys Leu Gln Glu Leu Glu Gln Glu Tyr Gly Glu Pro Phe Leu 
    130                 135                 140                 


Ala Ala Met Glu Lys Leu Leu Phe Glu Tyr Leu Cys Gln Leu Glu Lys 
145                 150                 155                 160 


Ala Leu Pro Thr Pro Gln Ala Gln Gln Leu Gln Asp Val Leu Ser Trp 
                165                 170                 175     


Met Gln Pro Gly Val Ser Ile Thr Ser Ser Leu Ala Trp Arg Gln Tyr 
            180                 185                 190         


Gly Val Asp Met Gly Trp Leu Leu Pro Glu Cys Ser Val Thr Asp Ser 
        195                 200                 205             


Val Asn Leu Ala Glu Pro Met Glu Gln Asn Pro Pro Gln Gln Gln Arg 
    210                 215                 220                 


Leu Ala Leu His Asn Pro Leu Pro Lys Ala Lys Pro Gly Thr His Leu 
225                 230                 235                 240 


Pro Gln Gly Pro Ser Ser Arg Thr His Pro Glu Pro Leu Ala Gly Arg 
                245                 250                 255     


His Phe Asn Leu Ala Pro Leu Gly Arg Arg Arg Val Gln Ser Gln Trp 
            260                 265                 270         


Ala Ser Thr Arg Gly Gly His Lys Glu Arg Pro Thr Val Met Leu Phe 
        275                 280                 285             


Pro Phe Arg Asn Leu Gly Ser Pro Thr Gln Val Ile Ser Lys Pro Glu 
    290                 295                 300                 


Ser Lys Glu Glu His Ala Ile Tyr Thr Ala Asp Leu Ala Met Gly Thr 
305                 310                 315                 320 


Arg Ala Ala Ser Thr Gly Lys Ser Lys Ser Pro Cys Gln Thr Leu Gly 
                325                 330                 335     


Gly Arg Ala Leu Lys Glu Asn Pro Val Asp Leu Pro Ala Thr Glu Gln 
            340                 345                 350         


Lys Glu 
        


<210>  348
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Gly Asp His Leu Asp Leu Leu Leu Gly Val Val Leu Met Ala Gly 
1               5                   10                  15      


Pro Val Phe Gly Ile Pro Ser Cys Ser Phe Asp Gly Arg Ile Ala Phe 
            20                  25                  30          


Tyr Arg Phe Cys Asn Leu Thr Gln Val Pro Gln Val Leu Asn Thr Thr 
        35                  40                  45              


Glu Arg Leu Leu Leu Ser Phe Asn Tyr Ile Arg Thr Val Thr Ala Ser 
    50                  55                  60                  


Ser Phe Pro Phe Leu Glu Gln Leu Gln Leu Leu Glu Leu Gly Ser Gln 
65                  70                  75                  80  


Tyr Thr Pro Leu Thr Ile Asp Lys Glu Ala Phe Arg Asn Leu Pro Asn 
                85                  90                  95      


Leu Arg Ile Leu Asp Leu Gly Ser Ser Lys Ile Tyr Phe Leu His Pro 
            100                 105                 110         


Asp Ala Phe Gln Gly Leu Phe His Leu Phe Glu Leu Arg Leu Tyr Phe 
        115                 120                 125             


Cys Gly Leu Ser Asp Ala Val Leu Lys Asp Gly Tyr Phe Arg Asn Leu 
    130                 135                 140                 


Lys Ala Leu Thr Arg Leu Asp Leu Ser Lys Asn Gln Ile Arg Ser Leu 
145                 150                 155                 160 


Tyr Leu His Pro Ser Phe Gly Lys Leu Asn Ser Leu Lys Ser Ile Asp 
                165                 170                 175     


Phe Ser Ser Asn Gln Ile Phe Leu Val Cys Glu His Glu Leu Glu Pro 
            180                 185                 190         


Leu Gln Gly Lys Thr Leu Ser Phe Phe Ser Leu Ala Ala Asn Ser Leu 
        195                 200                 205             


Tyr Ser Arg Val Ser Val Asp Trp Gly Lys Cys Met Asn Pro Phe Arg 
    210                 215                 220                 


Asn Met Val Leu Glu Ile Leu Asp Val Ser Gly Asn Gly Trp Thr Val 
225                 230                 235                 240 


Asp Ile Thr Gly Asn Phe Ser Asn Ala Ile Ser Lys Ser Gln Ala Phe 
                245                 250                 255     


Ser Leu Ile Leu Ala His His Ile Met Gly Ala Gly Phe Gly Phe His 
            260                 265                 270         


Asn Ile Lys Asp Pro Asp Gln Asn Thr Phe Ala Gly Leu Ala Arg Ser 
        275                 280                 285             


Ser Val Arg His Leu Asp Leu Ser His Gly Phe Val Phe Ser Leu Asn 
    290                 295                 300                 


Ser Arg Val Phe Glu Thr Leu Lys Asp Leu Lys Val Leu Asn Leu Ala 
305                 310                 315                 320 


Tyr Asn Lys Ile Asn Lys Ile Ala Asp Glu Ala Phe Tyr Gly Leu Asp 
                325                 330                 335     


Asn Leu Gln Val Leu Asn Leu Ser Tyr Asn Leu Leu Gly Glu Leu Tyr 
            340                 345                 350         


Ser Ser Asn Phe Tyr Gly Leu Pro Lys Val Ala Tyr Ile Asp Leu Gln 
        355                 360                 365             


Lys Asn His Ile Ala Ile Ile Gln Asp Gln Thr Phe Lys Phe Leu Glu 
    370                 375                 380                 


Lys Leu Gln Thr Leu Asp Leu Arg Asp Asn Ala Leu Thr Thr Ile His 
385                 390                 395                 400 


Phe Ile Pro Ser Ile Pro Asp Ile Phe Leu Ser Gly Asn Lys Leu Val 
                405                 410                 415     


Thr Leu Pro Lys Ile Asn Leu Thr Ala Asn Leu Ile His Leu Ser Glu 
            420                 425                 430         


Asn Arg Leu Glu Asn Leu Asp Ile Leu Tyr Phe Leu Leu Arg Val Pro 
        435                 440                 445             


His Leu Gln Ile Leu Ile Leu Asn Gln Asn Arg Phe Ser Ser Cys Ser 
    450                 455                 460                 


Gly Asp Gln Thr Pro Ser Glu Asn Pro Ser Leu Glu Gln Leu Phe Leu 
465                 470                 475                 480 


Gly Glu Asn Met Leu Gln Leu Ala Trp Glu Thr Glu Leu Cys Trp Asp 
                485                 490                 495     


Val Phe Glu Gly Leu Ser His Leu Gln Val Leu Tyr Leu Asn His Asn 
            500                 505                 510         


Tyr Leu Asn Ser Leu Pro Pro Gly Val Phe Ser His Leu Thr Ala Leu 
        515                 520                 525             


Arg Gly Leu Ser Leu Asn Ser Asn Arg Leu Thr Val Leu Ser His Asn 
    530                 535                 540                 


Asp Leu Pro Ala Asn Leu Glu Ile Leu Asp Ile Ser Arg Asn Gln Leu 
545                 550                 555                 560 


Leu Ala Pro Asn Pro Asp Val Phe Val Ser Leu Ser Val Leu Asp Ile 
                565                 570                 575     


Thr His Asn Lys Phe Ile Cys Glu Cys Glu Leu Ser Thr Phe Ile Asn 
            580                 585                 590         


Trp Leu Asn His Thr Asn Val Thr Ile Ala Gly Pro Pro Ala Asp Ile 
        595                 600                 605             


Tyr Cys Val Tyr Pro Asp Ser Phe Ser Gly Val Ser Leu Phe Ser Leu 
    610                 615                 620                 


Ser Thr Glu Gly Cys Asp Glu Glu Glu Val Leu Lys Ser Leu Lys Phe 
625                 630                 635                 640 


Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu Met Thr 
                645                 650                 655     


Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys Tyr Lys 
            660                 665                 670         


Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr Glu Pro 
        675                 680                 685             


Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys Asp Phe 
    690                 695                 700                 


Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln Tyr Ser 
705                 710                 715                 720 


Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe Val Pro 
                725                 730                 735     


Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn Ser Arg 
            740                 745                 750         


Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly Trp Cys 
        755                 760                 765             


Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp Leu Asn 
    770                 775                 780                 


Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr Gln Leu 
785                 790                 795                 800 


Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln Tyr Leu 
                805                 810                 815     


Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His Lys Leu 
            820                 825                 830         


Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp Asn Asn 
        835                 840                 845             


Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
    850                 855             


<210>  349
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Gly Ser Gln His Ser Ala Ala Ala Arg Pro Ser Ser Cys Arg Arg 
1               5                   10                  15      


Lys Gln Glu Asp Asp Arg Asp Gly Leu Leu Ala Glu Arg Glu Gln Glu 
            20                  25                  30          


Glu Ala Ile Ala Gln Phe Pro Tyr Val Glu Phe Thr Gly Arg Asp Ser 
        35                  40                  45              


Ile Thr Cys Leu Thr Cys Gln Gly Thr Gly Tyr Ile Pro Thr Glu Gln 
    50                  55                  60                  


Val Asn Glu Leu Val Ala Leu Ile Pro His Ser Asp Gln Arg Leu Arg 
65                  70                  75                  80  


Pro Gln Arg Thr Lys Gln Tyr Val Leu Leu Ser Ile Leu Leu Cys Leu 
                85                  90                  95      


Leu Ala Ser Gly Leu Val Val Phe Phe Leu Phe Pro His Ser Val Leu 
            100                 105                 110         


Val Asp Asp Asp Gly Ile Lys Val Val Lys Val Thr Phe Asn Lys Gln 
        115                 120                 125             


Asp Ser Leu Val Ile Leu Thr Ile Met Ala Thr Leu Lys Ile Arg Asn 
    130                 135                 140                 


Ser Asn Phe Tyr Thr Val Ala Val Thr Ser Leu Ser Ser Gln Ile Gln 
145                 150                 155                 160 


Tyr Met Asn Thr Val Val Ser Thr Tyr Val Thr Thr Asn Val Ser Leu 
                165                 170                 175     


Ile Pro Pro Arg Ser Glu Gln Leu Val Asn Phe Thr Gly Lys Ala Glu 
            180                 185                 190         


Met Gly Gly Pro Phe Ser Tyr Val Tyr Phe Phe Cys Thr Val Pro Glu 
        195                 200                 205             


Ile Leu Val His Asn Ile Val Ile Phe Met Arg Thr Ser Val Lys Ile 
    210                 215                 220                 


Ser Tyr Ile Gly Leu Met Thr Gln Ser Ser Leu Glu Thr His His Tyr 
225                 230                 235                 240 


Val Asp Cys Gly Gly Asn Ser Thr Ala Ile 
                245                 250 


<210>  350
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Leu Pro Asn Val Gly Ser Pro Pro Leu Pro Phe Arg Lys Cys Pro 
1               5                   10                  15      


Ser Gly Ala Gly Arg Thr Asn Arg Ala Ser Ala Val Ala Arg Thr Ser 
            20                  25                  30          


Ala Pro Glu Thr Arg Arg Gly Arg Ala Pro Ser Ser Gly Asp Ala Lys 
        35                  40                  45              


Met Ala Glu Gly Ala Arg Ala Arg Gly Pro Arg Gly Cys Arg Asp Arg 
    50                  55                  60                  


Asp Gly Pro Ala Gly Gly Ala Gly Lys Met Ala Ala Pro Arg Arg Gly 
65                  70                  75                  80  


Arg Gly Ser Ser Thr Val Leu Ser Ser Val Pro Leu Gln Met Leu Phe 
                85                  90                  95      


Tyr Leu Ser Gly Thr Tyr Tyr Ala Leu Tyr Phe Leu Ala Thr Leu Leu 
            100                 105                 110         


Met Ile Thr Tyr Lys Ser Gln Val Phe Ser Tyr Pro His Arg Tyr Leu 
        115                 120                 125             


Val Leu Asp Leu Ala Leu Leu Phe Leu Met Gly Ile Leu Glu Ala Val 
    130                 135                 140                 


Arg Leu Tyr Leu Gly Thr Arg Gly Asn Leu Thr Glu Ala Glu Arg Pro 
145                 150                 155                 160 


Leu Ala Ala Ser Leu Ala Leu Thr Ala Gly Thr Ala Leu Leu Ser Ala 
                165                 170                 175     


His Phe Leu Leu Trp Gln Ala Leu Val Leu Trp Ala Asp Trp Ala Leu 
            180                 185                 190         


Ser Ala Thr Leu Leu Ala Leu His Gly Leu Glu Ala Val Leu Gln Val 
        195                 200                 205             


Val Ala Ile Ala Ala Phe Thr Arg 
    210                 215     


<210>  351
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Gln Leu Glu Ile Gln Val Ala Leu Asn Phe Ile Ile Ser Tyr Leu 
1               5                   10                  15      


Tyr Asn Lys Leu Pro Arg Arg Arg Val Asn Ile Phe Gly Glu Glu Leu 
            20                  25                  30          


Glu Arg Leu Leu Lys Lys Lys Tyr Glu Gly His Trp Tyr Pro Glu Lys 
        35                  40                  45              


Pro Tyr Lys Gly Ser Gly Phe Arg Cys Ile His Ile Gly Glu Lys Val 
    50                  55                  60                  


Asp Pro Val Ile Glu Gln Ala Ser Lys Glu Ser Gly Leu Asp Ile Asp 
65                  70                  75                  80  


Asp Val Arg Gly Asn Leu Pro Gln Asp Leu Ser Val Trp Ile Asp Pro 
                85                  90                  95      


Phe Glu Val Ser Tyr Gln Ile Gly Glu Lys Gly Pro Val Lys Val Leu 
            100                 105                 110         


Tyr Val Asp Asp Asn Asn Glu Asn Gly Cys Glu Leu Asp Lys Glu Ile 
        115                 120                 125             


Lys Asn Ser Phe Asn Pro Glu Ala Gln Val Phe Met Pro Ile Ser Asp 
    130                 135                 140                 


Pro Ala Ser Ser Val Ser Ser Ser Pro Ser Pro Pro Phe Gly His Ser 
145                 150                 155                 160 


Ala Ala Val Ser Pro Thr Phe Met Pro Arg Ser Thr Gln Pro Leu Thr 
                165                 170                 175     


Phe Thr Thr Ala Thr Phe Ala Ala Thr Lys Phe Gly Ser Thr Lys Met 
            180                 185                 190         


Lys Asn Ser Gly Arg Ser Asn Lys Val Ala Arg Thr Ser Pro Ile Asn 
        195                 200                 205             


Leu Gly Leu Asn Val Asn Asp Leu Leu Lys Gln Lys Ala Ile Ser Ser 
    210                 215                 220                 


Ser Met His Ser Leu Tyr Gly Leu Gly Leu Gly Ser Gln Gln Gln Pro 
225                 230                 235                 240 


Gln Gln Gln Gln Gln Pro Ala Gln Pro Pro Pro Pro Pro Pro Pro Pro 
                245                 250                 255     


Gln Gln Gln Gln Gln Gln Lys Thr Ser Ala Leu Ser Pro Asn Ala Lys 
            260                 265                 270         


Glu Phe Ile Phe Pro Asn Met Gln Gly Gln Gly Ser Ser Thr Asn Gly 
        275                 280                 285             


Met Phe Pro Gly Asp Ser Pro Leu Asn Leu Ser Pro Leu Gln Tyr Ser 
    290                 295                 300                 


Asn Ala Phe Asp Val Phe Ala Ala Tyr Gly Gly Leu Asn Glu Lys Ser 
305                 310                 315                 320 


Phe Val Asp Gly Leu Asn Phe Ser Leu Asn Asn Met Gln Tyr Ser Asn 
                325                 330                 335     


Gln Gln Phe Gln Pro Val Met Ala Asn 
            340                 345 


<210>  352
<211>  1249
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Ala Thr Ala Ala Thr Glu Glu Pro Phe Pro Phe His Gly Leu Leu 
1               5                   10                  15      


Pro Lys Lys Glu Thr Gly Ala Ala Ser Phe Leu Cys Arg Tyr Pro Glu 
            20                  25                  30          


Tyr Asp Gly Arg Gly Val Leu Ile Ala Val Leu Asp Thr Gly Val Asp 
        35                  40                  45              


Pro Gly Ala Pro Gly Met Gln Val Thr Thr Asp Gly Lys Pro Lys Ile 
    50                  55                  60                  


Val Asp Ile Ile Asp Thr Thr Gly Ser Gly Asp Val Asn Thr Ala Thr 
65                  70                  75                  80  


Glu Val Glu Pro Lys Asp Gly Glu Ile Val Gly Leu Ser Gly Arg Val 
                85                  90                  95      


Leu Lys Ile Pro Ala Ser Trp Thr Asn Pro Ser Gly Lys Tyr His Ile 
            100                 105                 110         


Gly Ile Lys Asn Gly Tyr Asp Phe Tyr Pro Lys Ala Leu Lys Glu Arg 
        115                 120                 125             


Ile Gln Lys Glu Arg Lys Glu Lys Ile Trp Asp Pro Val His Arg Val 
    130                 135                 140                 


Ala Leu Ala Glu Ala Cys Arg Lys Gln Glu Glu Phe Asp Val Ala Asn 
145                 150                 155                 160 


Asn Gly Ser Ser Gln Ala Asn Lys Leu Ile Lys Glu Glu Leu Gln Ser 
                165                 170                 175     


Gln Val Glu Leu Leu Asn Ser Phe Glu Lys Lys Tyr Ser Asp Pro Gly 
            180                 185                 190         


Pro Val Tyr Asp Cys Leu Val Trp His Asp Gly Glu Val Trp Arg Ala 
        195                 200                 205             


Cys Ile Asp Ser Asn Glu Asp Gly Asp Leu Ser Lys Ser Thr Val Leu 
    210                 215                 220                 


Arg Asn Tyr Lys Glu Ala Gln Glu Tyr Gly Ser Phe Gly Thr Ala Glu 
225                 230                 235                 240 


Met Leu Asn Tyr Ser Val Asn Ile Tyr Asp Asp Gly Asn Leu Leu Ser 
                245                 250                 255     


Ile Val Thr Ser Gly Gly Ala His Gly Thr His Val Ala Ser Ile Ala 
            260                 265                 270         


Ala Gly His Phe Pro Glu Glu Pro Glu Arg Asn Gly Val Ala Pro Gly 
        275                 280                 285             


Ala Gln Ile Leu Ser Ile Lys Ile Gly Asp Thr Arg Leu Ser Thr Met 
    290                 295                 300                 


Glu Thr Gly Thr Gly Leu Ile Arg Ala Met Ile Glu Val Ile Asn His 
305                 310                 315                 320 


Lys Cys Asp Leu Val Asn Tyr Ser Tyr Gly Glu Ala Thr His Trp Pro 
                325                 330                 335     


Asn Ser Gly Arg Ile Cys Glu Val Ile Asn Glu Ala Val Trp Lys His 
            340                 345                 350         


Asn Ile Ile Tyr Val Ser Ser Ala Gly Asn Asn Gly Pro Cys Leu Ser 
        355                 360                 365             


Thr Val Gly Cys Pro Gly Gly Thr Thr Ser Ser Val Ile Gly Val Gly 
    370                 375                 380                 


Ala Tyr Val Ser Pro Asp Met Met Val Ala Glu Tyr Ser Leu Arg Glu 
385                 390                 395                 400 


Lys Leu Pro Ala Asn Gln Tyr Thr Trp Ser Ser Arg Gly Pro Ser Ala 
                405                 410                 415     


Asp Gly Ala Leu Gly Val Ser Ile Ser Ala Pro Gly Gly Ala Ile Ala 
            420                 425                 430         


Ser Val Pro Asn Trp Thr Leu Arg Gly Thr Gln Leu Met Asn Gly Thr 
        435                 440                 445             


Ser Met Ser Ser Pro Asn Ala Cys Gly Gly Ile Ala Leu Ile Leu Ser 
    450                 455                 460                 


Gly Leu Lys Ala Asn Asn Ile Asp Tyr Thr Val His Ser Val Arg Arg 
465                 470                 475                 480 


Ala Leu Glu Asn Thr Ala Val Lys Ala Asp Asn Ile Glu Val Phe Ala 
                485                 490                 495     


Gln Gly His Gly Ile Ile Gln Val Asp Lys Ala Tyr Asp Tyr Leu Val 
            500                 505                 510         


Gln Asn Thr Ser Phe Ala Asn Lys Leu Gly Phe Thr Val Thr Val Gly 
        515                 520                 525             


Asn Asn Arg Gly Ile Tyr Leu Arg Asp Pro Val Gln Val Ala Ala Pro 
    530                 535                 540                 


Ser Asp His Gly Val Gly Ile Glu Pro Val Phe Pro Glu Asn Thr Glu 
545                 550                 555                 560 


Asn Ser Glu Lys Ile Ser Leu Gln Leu His Leu Ala Leu Thr Ser Asn 
                565                 570                 575     


Ser Ser Trp Val Gln Cys Pro Ser His Leu Glu Leu Met Asn Gln Cys 
            580                 585                 590         


Arg His Ile Asn Ile Arg Val Asp Pro Arg Gly Leu Arg Glu Gly Leu 
        595                 600                 605             


His Tyr Thr Glu Val Cys Gly Tyr Asp Ile Ala Ser Pro Asn Ala Gly 
    610                 615                 620                 


Pro Leu Phe Arg Val Pro Ile Thr Ala Val Ile Ala Ala Lys Val Asn 
625                 630                 635                 640 


Glu Ser Ser His Tyr Asp Leu Ala Phe Thr Asp Val His Phe Lys Pro 
                645                 650                 655     


Gly Gln Ile Arg Arg His Phe Ile Glu Val Pro Glu Gly Ala Thr Trp 
            660                 665                 670         


Ala Glu Val Thr Val Cys Ser Cys Ser Ser Glu Val Ser Ala Lys Phe 
        675                 680                 685             


Val Leu His Ala Val Gln Leu Val Lys Gln Arg Ala Tyr Arg Ser His 
    690                 695                 700                 


Glu Phe Tyr Lys Phe Cys Ser Leu Pro Glu Lys Gly Thr Leu Thr Glu 
705                 710                 715                 720 


Ala Phe Pro Val Leu Gly Gly Lys Ala Ile Glu Phe Cys Ile Ala Arg 
                725                 730                 735     


Trp Trp Ala Ser Leu Ser Asp Val Asn Ile Asp Tyr Thr Ile Ser Phe 
            740                 745                 750         


His Gly Ile Val Cys Thr Ala Pro Gln Leu Asn Ile His Ala Ser Glu 
        755                 760                 765             


Gly Ile Asn Arg Phe Asp Val Gln Ser Ser Leu Lys Tyr Glu Asp Leu 
    770                 775                 780                 


Ala Pro Cys Ile Thr Leu Lys Asn Trp Val Gln Thr Leu Arg Pro Val 
785                 790                 795                 800 


Ser Ala Lys Thr Lys Pro Leu Gly Ser Arg Asp Val Leu Pro Asn Asn 
                805                 810                 815     


Arg Gln Leu Tyr Glu Met Val Leu Thr Tyr Asn Phe His Gln Pro Lys 
            820                 825                 830         


Ser Gly Glu Val Thr Pro Ser Cys Pro Leu Leu Cys Glu Leu Leu Tyr 
        835                 840                 845             


Glu Ser Glu Phe Asp Ser Gln Leu Trp Ile Ile Phe Asp Gln Asn Lys 
    850                 855                 860                 


Arg Gln Met Gly Ser Gly Asp Ala Tyr Pro His Gln Tyr Ser Leu Lys 
865                 870                 875                 880 


Leu Glu Lys Gly Asp Tyr Thr Ile Arg Leu Gln Ile Arg His Glu Gln 
                885                 890                 895     


Ile Ser Asp Leu Glu Arg Leu Lys Asp Leu Pro Phe Ile Val Ser His 
            900                 905                 910         


Arg Leu Ser Asn Thr Leu Ser Leu Asp Ile His Glu Asn His Ser Phe 
        915                 920                 925             


Ala Leu Leu Gly Lys Lys Lys Ser Ser Asn Leu Thr Leu Pro Pro Lys 
    930                 935                 940                 


Tyr Asn Gln Pro Phe Phe Val Thr Ser Leu Pro Asp Asp Lys Ile Pro 
945                 950                 955                 960 


Lys Gly Ala Gly Pro Gly Cys Tyr Leu Ala Gly Ser Leu Thr Leu Ser 
                965                 970                 975     


Lys Thr Glu Leu Gly Lys Lys Ala Asp Val Ile Pro Val His Tyr Tyr 
            980                 985                 990         


Leu Ile Pro Pro Pro Thr Lys Thr  Lys Asn Gly Ser Lys  Asp Lys Glu 
        995                 1000                 1005             


Lys Asp  Ser Glu Lys Glu Lys  Asp Leu Lys Glu Glu  Phe Thr Glu 
    1010                 1015                 1020             


Ala Leu  Arg Asp Leu Lys Ile  Gln Trp Met Thr Lys  Leu Asp Ser 
    1025                 1030                 1035             


Ser Asp  Ile Tyr Asn Glu Leu  Lys Glu Thr Tyr Pro  Asn Tyr Leu 
    1040                 1045                 1050             


Pro Leu  Tyr Val Ala Arg Leu  His Gln Leu Asp Ala  Glu Lys Glu 
    1055                 1060                 1065             


Arg Met  Lys Arg Leu Asn Glu  Ile Val Asp Ala Ala  Asn Ala Val 
    1070                 1075                 1080             


Ile Ser  His Ile Asp Gln Thr  Ala Leu Ala Val Tyr  Ile Ala Met 
    1085                 1090                 1095             


Lys Thr  Asp Pro Arg Pro Asp  Ala Ala Thr Ile Lys  Asn Asp Met 
    1100                 1105                 1110             


Asp Lys  Gln Lys Ser Thr Leu  Val Asp Ala Leu Cys  Arg Lys Gly 
    1115                 1120                 1125             


Cys Ala  Leu Ala Asp His Leu  Leu His Thr Gln Ala  Gln Asp Gly 
    1130                 1135                 1140             


Ala Ile  Ser Thr Asp Ala Glu  Gly Lys Glu Glu Glu  Gly Glu Ser 
    1145                 1150                 1155             


Pro Leu  Asp Ser Leu Ala Glu  Thr Phe Trp Glu Thr  Thr Lys Trp 
    1160                 1165                 1170             


Thr Asp  Leu Phe Asp Asn Lys  Val Leu Thr Phe Ala  Tyr Lys His 
    1175                 1180                 1185             


Ala Leu  Val Asn Lys Met Tyr  Gly Arg Gly Leu Lys  Phe Ala Thr 
    1190                 1195                 1200             


Lys Leu  Val Glu Glu Lys Pro  Thr Lys Glu Asn Trp  Lys Asn Cys 
    1205                 1210                 1215             


Ile Gln  Leu Met Lys Leu Leu  Gly Trp Thr His Cys  Ala Ser Phe 
    1220                 1225                 1230             


Thr Glu  Asn Trp Leu Pro Ile  Met Tyr Pro Pro Asp  Tyr Cys Val 
    1235                 1240                 1245             


Phe 
    


<210>  353
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Pro Pro Gln Leu Gln Glu Thr Arg Met Asn Arg Ser Ile Pro Val 
1               5                   10                  15      


Glu Val Asp Glu Ser Glu Pro Tyr Pro Ser Gln Leu Leu Lys Pro Ile 
            20                  25                  30          


Pro Glu Tyr Ser Pro Glu Glu Glu Ser Glu Pro Pro Ala Pro Asn Ile 
        35                  40                  45              


Arg Asn Met Ala Pro Asn Ser Leu Ser Ala Pro Thr Met Leu His Asn 
    50                  55                  60                  


Ser Ser Gly Asp Phe Ser Gln Ala His Ser Thr Leu Lys Leu Ala Asn 
65                  70                  75                  80  


His Gln Arg Pro Val Ser Arg Gln Val Thr Cys Leu Arg Thr Gln Val 
                85                  90                  95      


Leu Glu Asp Ser Glu Asp Ser Phe Cys Arg Arg His Pro Gly Leu Gly 
            100                 105                 110         


Lys Ala Phe Pro Ser Gly Cys Ser Ala Val Ser Glu Pro Ala Ser Glu 
        115                 120                 125             


Ser Val Val Gly Ala Leu Pro Ala Glu His Gln Phe Ser Phe Met Glu 
    130                 135                 140                 


Lys Arg Asn Gln Trp Leu Val Ser Gln Leu Ser Ala Ala Ser Pro Asp 
145                 150                 155                 160 


Thr Gly His Asp Ser Asp Lys Ser Asp Gln Ser Leu Pro Asn Ala Ser 
                165                 170                 175     


Ala Asp Ser Leu Gly Gly Ser Gln Glu Met Val Gln Arg Pro Gln Pro 
            180                 185                 190         


His Arg Asn Arg Ala Gly Leu Asp Leu Pro Thr Ile Asp Thr Gly Tyr 
        195                 200                 205             


Asp Ser Gln Pro Gln Asp Val Leu Gly Ile Arg Gln Leu Glu Arg Pro 
    210                 215                 220                 


Leu Pro Leu Thr Ser Val Cys Tyr Pro Gln Asp Leu Pro Arg Pro Leu 
225                 230                 235                 240 


Arg Ser Arg Glu Phe Pro Gln Phe Glu Pro Gln Arg Tyr Pro Ala Cys 
                245                 250                 255     


Ala Gln Met Leu Pro Pro Asn Leu Ser Pro His Ala Pro Trp Asn Tyr 
            260                 265                 270         


His Tyr His Cys Pro Gly Ser Pro Asp His Gln Val Pro Tyr Gly His 
        275                 280                 285             


Asp Tyr Pro Arg Ala Ala Tyr Gln Gln Val Ile Gln Pro Ala Leu Pro 
    290                 295                 300                 


Gly Gln Pro Leu Pro Gly Ala Ser Val Arg Gly Leu His Pro Val Gln 
305                 310                 315                 320 


Lys Val Ile Leu Asn Tyr Pro Ser Pro Trp Asp His Glu Glu Arg Pro 
                325                 330                 335     


Ala Gln Arg Asp Cys Ser Phe Pro Gly Leu Pro Arg His Gln Asp Gln 
            340                 345                 350         


Pro His His Gln Pro Pro Asn Arg Ala Gly Ala Pro Gly Glu Ser Leu 
        355                 360                 365             


Glu Cys Pro Ala Glu Leu Arg Pro Gln Val Pro Gln Pro Pro Ser Pro 
    370                 375                 380                 


Ala Ala Val Pro Arg Pro Pro Ser Asn Pro Pro Ala Arg Gly Thr Leu 
385                 390                 395                 400 


Lys Thr Ser Asn Leu Pro Glu Glu Leu Arg Lys Val Phe Ile Thr Tyr 
                405                 410                 415     


Ser Met Asp Thr Ala Met Glu Val Val Lys Phe Val Asn Phe Leu Leu 
            420                 425                 430         


Val Asn Gly Phe Gln Thr Ala Ile Asp Ile Phe Glu Asp Arg Ile Arg 
        435                 440                 445             


Gly Ile Asp Ile Ile Lys Trp Met Glu Arg Tyr Leu Arg Asp Lys Thr 
    450                 455                 460                 


Val Met Ile Ile Val Ala Ile Ser Pro Lys Tyr Lys Gln Asp Val Glu 
465                 470                 475                 480 


Gly Ala Glu Ser Gln Leu Asp Glu Asp Glu His Gly Leu His Thr Lys 
                485                 490                 495     


Tyr Ile His Arg Met Met Gln Ile Glu Phe Ile Lys Gln Gly Ser Met 
            500                 505                 510         


Asn Phe Arg Phe Ile Pro Val Leu Phe Pro Asn Ala Lys Lys Glu His 
        515                 520                 525             


Val Pro Thr Trp Leu Gln Asn Thr His Val Tyr Ser Trp Pro Lys Asn 
    530                 535                 540                 


Lys Lys Asn Ile Leu Leu Arg Leu Leu Arg Glu Glu Glu Tyr Val Ala 
545                 550                 555                 560 


Pro Pro Arg Gly Pro Leu Pro Thr Leu Gln Val Val Pro Leu 
                565                 570                 


<210>  354
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210>  355
<211>  845
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Glu Leu Trp Arg Gln Cys Thr His Trp Leu Ile Gln Cys Arg Val 
1               5                   10                  15      


Leu Pro Pro Ser His Arg Val Thr Trp Asp Gly Ala Gln Val Cys Glu 
            20                  25                  30          


Leu Ala Gln Ala Leu Arg Asp Gly Val Leu Leu Cys Gln Leu Leu Asn 
        35                  40                  45              


Asn Leu Leu Pro His Ala Ile Asn Leu Arg Glu Val Asn Leu Arg Pro 
    50                  55                  60                  


Gln Met Ser Gln Phe Leu Cys Leu Lys Asn Ile Arg Thr Phe Leu Ser 
65                  70                  75                  80  


Thr Cys Cys Glu Lys Phe Gly Leu Lys Arg Ser Glu Leu Phe Glu Ala 
                85                  90                  95      


Phe Asp Leu Phe Asp Val Gln Asp Phe Gly Lys Val Ile Tyr Thr Leu 
            100                 105                 110         


Ser Ala Leu Ser Trp Thr Pro Ile Ala Gln Asn Arg Gly Ile Met Pro 
        115                 120                 125             


Phe Pro Thr Glu Glu Glu Ser Val Gly Asp Glu Asp Ile Tyr Ser Gly 
    130                 135                 140                 


Leu Ser Asp Gln Ile Asp Asp Thr Val Glu Glu Asp Glu Asp Leu Tyr 
145                 150                 155                 160 


Asp Cys Val Glu Asn Glu Glu Ala Glu Gly Asp Glu Ile Tyr Glu Asp 
                165                 170                 175     


Leu Met Arg Ser Glu Pro Val Ser Met Pro Pro Lys Met Thr Glu Tyr 
            180                 185                 190         


Asp Lys Arg Cys Cys Cys Leu Arg Glu Ile Gln Gln Thr Glu Glu Lys 
        195                 200                 205             


Tyr Thr Asp Thr Leu Gly Ser Ile Gln Gln His Phe Leu Lys Pro Leu 
    210                 215                 220                 


Gln Arg Phe Leu Lys Pro Gln Asp Ile Glu Ile Ile Phe Ile Asn Ile 
225                 230                 235                 240 


Glu Asp Leu Leu Arg Val His Thr His Phe Leu Lys Glu Met Lys Glu 
                245                 250                 255     


Ala Leu Gly Thr Pro Gly Ala Ala Asn Leu Tyr Gln Val Phe Ile Lys 
            260                 265                 270         


Tyr Lys Glu Arg Phe Leu Val Tyr Gly Arg Tyr Cys Ser Gln Val Glu 
        275                 280                 285             


Ser Ala Ser Lys His Leu Asp Arg Val Ala Ala Ala Arg Glu Asp Val 
    290                 295                 300                 


Gln Met Lys Leu Glu Glu Cys Ser Gln Arg Ala Asn Asn Gly Arg Phe 
305                 310                 315                 320 


Thr Leu Arg Asp Leu Leu Met Val Pro Met Gln Arg Val Leu Lys Tyr 
                325                 330                 335     


His Leu Leu Leu Gln Glu Leu Val Lys His Thr Gln Glu Ala Met Glu 
            340                 345                 350         


Lys Glu Asn Leu Arg Leu Ala Leu Asp Ala Met Arg Asp Leu Ala Gln 
        355                 360                 365             


Cys Val Asn Glu Val Lys Arg Asp Asn Glu Thr Leu Arg Gln Ile Thr 
    370                 375                 380                 


Asn Phe Gln Leu Ser Ile Glu Asn Leu Asp Gln Ser Leu Ala His Tyr 
385                 390                 395                 400 


Gly Arg Pro Lys Ile Asp Gly Glu Leu Lys Ile Thr Ser Val Glu Arg 
                405                 410                 415     


Arg Ser Lys Met Asp Arg Tyr Ala Phe Leu Leu Asp Lys Ala Leu Leu 
            420                 425                 430         


Ile Cys Lys Arg Arg Gly Asp Ser Tyr Asp Leu Lys Asp Phe Val Asn 
        435                 440                 445             


Leu His Ser Phe Gln Val Arg Asp Asp Ser Ser Gly Asp Arg Asp Asn 
    450                 455                 460                 


Lys Lys Trp Ser His Met Phe Leu Leu Ile Glu Asp Gln Gly Ala Gln 
465                 470                 475                 480 


Gly Tyr Glu Leu Phe Phe Lys Thr Arg Glu Leu Lys Lys Lys Trp Met 
                485                 490                 495     


Glu Gln Phe Glu Met Ala Ile Ser Asn Ile Tyr Pro Glu Asn Ala Thr 
            500                 505                 510         


Ala Asn Gly His Asp Phe Gln Met Phe Ser Phe Glu Glu Thr Thr Ser 
        515                 520                 525             


Cys Lys Ala Cys Gln Met Leu Leu Arg Gly Thr Phe Tyr Gln Gly Tyr 
    530                 535                 540                 


Arg Cys His Arg Cys Arg Ala Ser Ala His Lys Glu Cys Leu Gly Arg 
545                 550                 555                 560 


Val Pro Pro Cys Gly Arg His Gly Gln Asp Phe Pro Gly Thr Met Lys 
                565                 570                 575     


Lys Asp Lys Leu His Arg Arg Ala Gln Asp Lys Lys Arg Asn Glu Leu 
            580                 585                 590         


Gly Leu Pro Lys Met Glu Val Phe Gln Glu Tyr Tyr Gly Leu Pro Pro 
        595                 600                 605             


Pro Pro Gly Ala Ile Gly Pro Phe Leu Arg Leu Asn Pro Gly Asp Ile 
    610                 615                 620                 


Val Glu Leu Thr Lys Ala Glu Ala Glu Gln Asn Trp Trp Glu Gly Arg 
625                 630                 635                 640 


Asn Thr Ser Thr Asn Glu Ile Gly Trp Phe Pro Cys Asn Arg Val Lys 
                645                 650                 655     


Pro Tyr Val His Gly Pro Pro Gln Asp Leu Ser Val His Leu Trp Tyr 
            660                 665                 670         


Ala Gly Pro Met Glu Arg Ala Gly Ala Glu Ser Ile Leu Ala Asn Arg 
        675                 680                 685             


Ser Asp Gly Thr Phe Leu Val Arg Gln Arg Val Lys Asp Ala Ala Glu 
    690                 695                 700                 


Phe Ala Ile Ser Ile Lys Tyr Asn Val Glu Val Lys His Ile Lys Ile 
705                 710                 715                 720 


Met Thr Ala Glu Gly Leu Tyr Arg Ile Thr Glu Lys Lys Ala Phe Arg 
                725                 730                 735     


Gly Leu Thr Glu Leu Val Glu Phe Tyr Gln Gln Asn Ser Leu Lys Asp 
            740                 745                 750         


Cys Phe Lys Ser Leu Asp Thr Thr Leu Gln Phe Pro Phe Lys Glu Pro 
        755                 760                 765             


Glu Lys Arg Thr Ile Ser Arg Pro Ala Val Gly Ser Thr Lys Tyr Phe 
    770                 775                 780                 


Gly Thr Ala Lys Ala Arg Tyr Asp Phe Cys Ala Arg Asp Arg Ser Glu 
785                 790                 795                 800 


Leu Ser Leu Lys Glu Gly Asp Ile Ile Lys Ile Leu Asn Lys Lys Gly 
                805                 810                 815     


Gln Gln Gly Trp Trp Arg Gly Glu Ile Tyr Gly Arg Val Gly Trp Phe 
            820                 825                 830         


Pro Ala Asn Tyr Val Glu Glu Asp Tyr Ser Glu Tyr Cys 
        835                 840                 845 


<210>  356
<211>  1336
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Ala Thr Glu Ile Gly Ser Pro Pro Arg Phe Phe His Met Pro Arg 
1               5                   10                  15      


Phe Gln His Gln Ala Pro Arg Gln Leu Phe Tyr Lys Arg Pro Asp Phe 
            20                  25                  30          


Ala Gln Gln Gln Ala Met Gln Gln Leu Thr Phe Asp Gly Lys Arg Met 
        35                  40                  45              


Arg Lys Ala Val Asn Arg Lys Thr Ile Asp Tyr Asn Pro Ser Val Ile 
    50                  55                  60                  


Lys Tyr Leu Glu Asn Arg Ile Trp Gln Arg Asp Gln Arg Asp Met Arg 
65                  70                  75                  80  


Ala Ile Gln Pro Asp Ala Gly Tyr Tyr Asn Asp Leu Val Pro Pro Ile 
                85                  90                  95      


Gly Met Leu Asn Asn Pro Met Asn Ala Val Thr Thr Lys Phe Val Arg 
            100                 105                 110         


Thr Ser Thr Asn Lys Val Lys Cys Pro Val Phe Val Val Arg Trp Thr 
        115                 120                 125             


Pro Glu Gly Arg Arg Leu Val Thr Gly Ala Ser Ser Gly Glu Phe Thr 
    130                 135                 140                 


Leu Trp Asn Gly Leu Thr Phe Asn Phe Glu Thr Ile Leu Gln Ala His 
145                 150                 155                 160 


Asp Ser Pro Val Arg Ala Met Thr Trp Ser His Asn Asp Met Trp Met 
                165                 170                 175     


Leu Thr Ala Asp His Gly Gly Tyr Val Lys Tyr Trp Gln Ser Asn Met 
            180                 185                 190         


Asn Asn Val Lys Met Phe Gln Ala His Lys Glu Ala Ile Arg Glu Ala 
        195                 200                 205             


Ser Phe Ser Pro Thr Asp Asn Lys Phe Ala Thr Cys Ser Asp Asp Gly 
    210                 215                 220                 


Thr Val Arg Ile Trp Asp Phe Leu Arg Cys His Glu Glu Arg Ile Leu 
225                 230                 235                 240 


Arg Gly His Gly Ala Asp Val Lys Cys Val Asp Trp His Pro Thr Lys 
                245                 250                 255     


Gly Leu Val Val Ser Gly Ser Lys Asp Ser Gln Gln Pro Ile Lys Phe 
            260                 265                 270         


Trp Asp Pro Lys Thr Gly Gln Ser Leu Ala Thr Leu His Ala His Lys 
        275                 280                 285             


Asn Thr Val Met Glu Val Lys Leu Asn Leu Asn Gly Asn Trp Leu Leu 
    290                 295                 300                 


Thr Ala Ser Arg Asp His Leu Cys Lys Leu Phe Asp Ile Arg Asn Leu 
305                 310                 315                 320 


Lys Glu Glu Leu Gln Val Phe Arg Gly His Lys Lys Glu Ala Thr Ala 
                325                 330                 335     


Val Ala Trp His Pro Val His Glu Gly Leu Phe Ala Ser Gly Gly Ser 
            340                 345                 350         


Asp Gly Ser Leu Leu Phe Trp His Val Gly Val Glu Lys Glu Val Gly 
        355                 360                 365             


Gly Met Glu Met Ala His Glu Gly Met Ile Trp Ser Leu Ala Trp His 
    370                 375                 380                 


Pro Leu Gly His Ile Leu Cys Ser Gly Ser Asn Asp His Thr Ser Lys 
385                 390                 395                 400 


Phe Trp Thr Arg Asn Arg Pro Gly Asp Lys Met Arg Asp Arg Tyr Asn 
                405                 410                 415     


Leu Asn Leu Leu Pro Gly Met Ser Glu Asp Gly Val Glu Tyr Asp Asp 
            420                 425                 430         


Leu Glu Pro Asn Ser Leu Ala Val Ile Pro Gly Met Gly Ile Pro Glu 
        435                 440                 445             


Gln Leu Lys Leu Ala Met Glu Gln Glu Gln Met Gly Lys Asp Glu Ser 
    450                 455                 460                 


Asn Glu Ile Glu Met Thr Ile Pro Gly Leu Asp Trp Gly Met Glu Glu 
465                 470                 475                 480 


Val Met Gln Lys Asp Gln Lys Lys Val Pro Gln Lys Lys Val Pro Tyr 
                485                 490                 495     


Ala Lys Pro Ile Pro Ala Gln Phe Gln Gln Ala Trp Met Gln Asn Lys 
            500                 505                 510         


Val Pro Ile Pro Ala Pro Asn Glu Val Leu Asn Asp Arg Lys Glu Asp 
        515                 520                 525             


Ile Lys Leu Glu Glu Lys Lys Lys Thr Gln Ala Glu Ile Glu Gln Glu 
    530                 535                 540                 


Met Ala Thr Leu Gln Tyr Thr Asn Pro Gln Leu Leu Glu Gln Leu Lys 
545                 550                 555                 560 


Ile Glu Arg Leu Ala Gln Lys Gln Val Glu Gln Ile Gln Pro Pro Pro 
                565                 570                 575     


Ser Ser Gly Thr Pro Leu Leu Gly Pro Gln Pro Phe Pro Gly Gln Gly 
            580                 585                 590         


Pro Met Ser Gln Ile Pro Gln Gly Phe Gln Gln Pro His Pro Ser Gln 
        595                 600                 605             


Gln Met Pro Met Asn Met Ala Gln Met Gly Pro Pro Gly Pro Gln Gly 
    610                 615                 620                 


Gln Phe Arg Pro Pro Gly Pro Gln Gly Gln Met Gly Pro Gln Gly Pro 
625                 630                 635                 640 


Pro Leu His Gln Gly Gly Gly Gly Pro Gln Gly Phe Met Gly Pro Gln 
                645                 650                 655     


Gly Pro Gln Gly Pro Pro Gln Gly Leu Pro Arg Pro Gln Asp Met His 
            660                 665                 670         


Gly Pro Gln Gly Met Gln Arg His Pro Gly Pro His Gly Pro Leu Gly 
        675                 680                 685             


Pro Gln Gly Pro Pro Gly Pro Gln Gly Ser Ser Gly Pro Gln Gly His 
    690                 695                 700                 


Met Gly Pro Gln Gly Pro Pro Gly Pro Gln Gly His Ile Gly Pro Gln 
705                 710                 715                 720 


Gly Pro Pro Gly Pro Gln Gly His Leu Gly Pro Gln Gly Pro Pro Gly 
                725                 730                 735     


Thr Gln Gly Met Gln Gly Pro Pro Gly Pro Arg Gly Met Gln Gly Pro 
            740                 745                 750         


Pro His Pro His Gly Ile Gln Gly Gly Pro Gly Ser Gln Gly Ile Gln 
        755                 760                 765             


Gly Pro Val Ser Gln Gly Pro Leu Met Gly Leu Asn Pro Arg Gly Met 
    770                 775                 780                 


Gln Gly Pro Pro Gly Pro Arg Glu Asn Gln Gly Pro Ala Pro Gln Gly 
785                 790                 795                 800 


Met Ile Met Gly His Pro Pro Gln Glu Met Arg Gly Pro His Pro Pro 
                805                 810                 815     


Gly Gly Leu Leu Gly His Gly Pro Gln Glu Met Arg Gly Pro Gln Glu 
            820                 825                 830         


Ile Arg Gly Met Gln Gly Pro Pro Pro Gln Gly Ser Met Leu Gly Pro 
        835                 840                 845             


Pro Gln Glu Leu Arg Gly Pro Pro Gly Ser Gln Ser Gln Gln Gly Pro 
    850                 855                 860                 


Pro Gln Gly Ser Leu Gly Pro Pro Pro Gln Gly Gly Met Gln Gly Pro 
865                 870                 875                 880 


Pro Gly Pro Gln Gly Gln Gln Asn Pro Ala Arg Gly Pro His Pro Ser 
                885                 890                 895     


Gln Gly Pro Ile Pro Phe Gln Gln Gln Lys Thr Pro Leu Leu Gly Asp 
            900                 905                 910         


Gly Pro Arg Ala Pro Phe Asn Gln Glu Gly Gln Ser Thr Gly Pro Pro 
        915                 920                 925             


Pro Leu Ile Pro Gly Leu Gly Gln Gln Gly Ala Gln Gly Arg Ile Pro 
    930                 935                 940                 


Pro Leu Asn Pro Gly Gln Gly Pro Gly Pro Asn Lys Gly Asp Ser Arg 
945                 950                 955                 960 


Gly Pro Pro Asn His His Met Gly Pro Met Ser Glu Arg Arg His Glu 
                965                 970                 975     


Gln Ser Gly Gly Pro Glu His Gly Pro Glu Arg Gly Pro Phe Arg Gly 
            980                 985                 990         


Gly Gln Asp Cys Arg Gly Pro Pro  Asp Arg Arg Gly Pro  His Pro Asp 
        995                 1000                 1005             


Phe Pro  Asp Asp Phe Ser Arg  Pro Asp Asp Phe His  Pro Asp Lys 
    1010                 1015                 1020             


Arg Phe  Gly His Arg Leu Arg  Glu Phe Glu Gly Arg  Gly Gly Pro 
    1025                 1030                 1035             


Leu Pro  Gln Glu Glu Lys Trp  Arg Arg Gly Gly Pro  Gly Pro Pro 
    1040                 1045                 1050             


Phe Pro  Pro Asp His Arg Glu  Phe Ser Glu Gly Asp  Gly Arg Gly 
    1055                 1060                 1065             


Ala Ala  Arg Gly Pro Pro Gly  Ala Trp Glu Gly Arg  Arg Pro Gly 
    1070                 1075                 1080             


Asp Glu  Arg Phe Pro Arg Asp  Pro Glu Asp Pro Arg  Phe Arg Gly 
    1085                 1090                 1095             


Arg Arg  Glu Glu Ser Phe Arg  Arg Gly Ala Pro Pro  Arg His Glu 
    1100                 1105                 1110             


Gly Arg  Ala Pro Pro Arg Gly  Arg Asp Gly Phe Pro  Gly Pro Glu 
    1115                 1120                 1125             


Asp Phe  Gly Pro Glu Glu Asn  Phe Asp Ala Ser Glu  Glu Ala Ala 
    1130                 1135                 1140             


Arg Gly  Arg Asp Leu Arg Gly  Arg Gly Arg Gly Thr  Pro Arg Gly 
    1145                 1150                 1155             


Gly Arg  Lys Gly Leu Leu Pro  Thr Pro Asp Glu Phe  Pro Arg Phe 
    1160                 1165                 1170             


Glu Gly  Gly Arg Lys Pro Asp  Ser Trp Asp Gly Asn  Arg Glu Pro 
    1175                 1180                 1185             


Gly Pro  Gly His Glu His Phe  Arg Asp Thr Pro Arg  Pro Asp His 
    1190                 1195                 1200             


Pro Pro  His Asp Gly His Ser  Pro Ala Ser Arg Glu  Arg Ser Ser 
    1205                 1210                 1215             


Ser Leu  Gln Gly Met Asp Met  Ala Ser Leu Pro Pro  Arg Lys Arg 
    1220                 1225                 1230             


Pro Trp  His Asp Gly Pro Gly  Thr Ser Glu His Arg  Glu Met Glu 
    1235                 1240                 1245             


Ala Pro  Gly Gly Pro Ser Glu  Asp Arg Gly Gly Lys  Gly Arg Gly 
    1250                 1255                 1260             


Gly Pro  Gly Pro Ala Gln Arg  Val Pro Lys Ser Gly  Arg Ser Ser 
    1265                 1270                 1275             


Ser Leu  Asp Gly Glu His His  Asp Gly Tyr His Arg  Asp Glu Pro 
    1280                 1285                 1290             


Phe Gly  Gly Pro Pro Gly Ser  Gly Thr Pro Ser Arg  Gly Gly Arg 
    1295                 1300                 1305             


Ser Gly  Ser Asn Trp Gly Arg  Gly Ser Asn Met Asn  Ser Gly Pro 
    1310                 1315                 1320             


Pro Arg  Arg Gly Ala Ser Arg  Gly Gly Gly Arg Gly  Arg 
    1325                 1330                 1335     


<210>  357
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Gly Arg Ile Phe Leu Asp His Ile Gly Gly Thr Arg Leu Phe Ser 
1               5                   10                  15      


Cys Ala Asn Cys Asp Thr Ile Leu Thr Asn Arg Ser Glu Leu Ile Ser 
            20                  25                  30          


Thr Arg Phe Thr Gly Ala Thr Gly Arg Ala Phe Leu Phe Asn Lys Val 
        35                  40                  45              


Val Asn Leu Gln Tyr Ser Glu Val Gln Asp Arg Val Met Leu Thr Gly 
    50                  55                  60                  


Arg His Met Val Arg Asp Val Ser Cys Lys Asn Cys Asn Ser Lys Leu 
65                  70                  75                  80  


Gly Trp Ile Tyr Glu Phe Ala Thr Glu Asp Ser Gln Arg Tyr Lys Glu 
                85                  90                  95      


Gly Arg Val Ile Leu Glu Arg Ala Leu Val Arg Glu Ser Glu Gly Phe 
            100                 105                 110         


Glu Glu His Val Pro Ser Asp Asn Ser 
        115                 120     


<210>  358
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Asp Phe Pro Gln His Ser Gln His Val Leu Glu Gln Leu Asn Gln 
1               5                   10                  15      


Gln Arg Gln Leu Gly Leu Leu Cys Asp Cys Thr Phe Val Val Asp Gly 
            20                  25                  30          


Val His Phe Lys Ala His Lys Ala Val Leu Ala Ala Cys Ser Glu Tyr 
        35                  40                  45              


Phe Lys Met Leu Phe Val Asp Gln Lys Asp Val Val His Leu Asp Ile 
    50                  55                  60                  


Ser Asn Ala Ala Gly Leu Gly Gln Val Leu Glu Phe Met Tyr Thr Ala 
65                  70                  75                  80  


Lys Leu Ser Leu Ser Pro Glu Asn Val Asp Asp Val Leu Ala Val Ala 
                85                  90                  95      


Thr Phe Leu Gln Met Gln Asp Ile Ile Thr Ala Cys His Ala Leu Lys 
            100                 105                 110         


Ser Leu Ala Glu Pro Ala Thr Ser Pro Gly Gly Asn Ala Glu Ala Leu 
        115                 120                 125             


Ala Thr Glu Gly Gly Asp Lys Arg Ala Lys Glu Glu Lys Val Ala Thr 
    130                 135                 140                 


Ser Thr Leu Ser Arg Leu Glu Gln Ala Gly Arg Ser Thr Pro Ile Gly 
145                 150                 155                 160 


Pro Ser Arg Asp Leu Lys Glu Glu Arg Gly Gly Gln Ala Gln Ser Ala 
                165                 170                 175     


Ala Ser Gly Ala Glu Gln Thr Glu Lys Ala Asp Ala Pro Arg Glu Pro 
            180                 185                 190         


Pro Pro Val Glu Leu Lys Pro Asp Pro Thr Ser Gly Met Ala Ala Ala 
        195                 200                 205             


Glu Ala Glu Ala Ala Leu Ser Glu Ser Ser Glu Gln Glu Met Glu Val 
    210                 215                 220                 


Glu Pro Ala Arg Lys Gly Glu Glu Glu Gln Lys Glu Gln Glu Glu Gln 
225                 230                 235                 240 


Glu Glu Glu Gly Ala Gly Pro Ala Glu Val Lys Glu Glu Gly Ser Gln 
                245                 250                 255     


Leu Glu Asn Gly Glu Ala Pro Glu Glu Asn Glu Asn Glu Glu Ser Ala 
            260                 265                 270         


Gly Thr Asp Ser Gly Gln Glu Leu Gly Ser Glu Ala Arg Gly Leu Arg 
        275                 280                 285             


Ser Gly Thr Tyr Gly Asp Arg Thr Glu Ser Lys Ala Tyr Gly Ser Val 
    290                 295                 300                 


Ile His Lys Cys Glu Asp Cys Gly Lys Glu Phe Thr His Thr Gly Asn 
305                 310                 315                 320 


Phe Lys Arg His Ile Arg Ile His Thr Gly Glu Lys Pro Phe Ser Cys 
                325                 330                 335     


Arg Glu Cys Ser Lys Ala Phe Ser Asp Pro Ala Ala Cys Lys Ala His 
            340                 345                 350         


Glu Lys Thr His Ser Pro Leu Lys Pro Tyr Gly Cys Glu Glu Cys Gly 
        355                 360                 365             


Lys Ser Tyr Arg Leu Ile Ser Leu Leu Asn Leu His Lys Lys Arg His 
    370                 375                 380                 


Ser Gly Glu Ala Arg Tyr Arg Cys Glu Asp Cys Gly Lys Leu Phe Thr 
385                 390                 395                 400 


Thr Ser Gly Asn Leu Lys Arg His Gln Leu Val His Ser Gly Glu Lys 
                405                 410                 415     


Pro Tyr Gln Cys Asp Tyr Cys Gly Arg Ser Phe Ser Asp Pro Thr Ser 
            420                 425                 430         


Lys Met Arg His Leu Glu Thr His Asp Thr Asp Lys Glu His Lys Cys 
        435                 440                 445             


Pro His Cys Asp Lys Lys Phe Asn Gln Val Gly Asn Leu Lys Ala His 
    450                 455                 460                 


Leu Lys Ile His Ile Ala Asp Gly Pro Leu Lys Cys Arg Glu Cys Gly 
465                 470                 475                 480 


Lys Gln Phe Thr Thr Ser Gly Asn Leu Lys Arg His Leu Arg Ile His 
                485                 490                 495     


Ser Gly Glu Lys Pro Tyr Val Cys Ile His Cys Gln Arg Gln Phe Ala 
            500                 505                 510         


Asp Pro Gly Ala Leu Gln Arg His Val Arg Ile His Thr Gly Glu Lys 
        515                 520                 525             


Pro Cys Gln Cys Val Met Cys Gly Lys Ala Phe Thr Gln Ala Ser Ser 
    530                 535                 540                 


Leu Ile Ala His Val Arg Gln His Thr Gly Glu Lys Pro Tyr Val Cys 
545                 550                 555                 560 


Glu Arg Cys Gly Lys Arg Phe Val Gln Ser Ser Gln Leu Ala Asn His 
                565                 570                 575     


Ile Arg His His Asp Asn Ile Arg Pro His Lys Cys Ser Val Cys Ser 
            580                 585                 590         


Lys Ala Phe Val Asn Val Gly Asp Leu Ser Lys His Ile Ile Ile His 
        595                 600                 605             


Thr Gly Glu Lys Pro Tyr Leu Cys Asp Lys Cys Gly Arg Gly Phe Asn 
    610                 615                 620                 


Arg Val Asp Asn Leu Arg Ser His Val Lys Thr Val His Gln Gly Lys 
625                 630                 635                 640 


Ala Gly Ile Lys Ile Leu Glu Pro Glu Glu Gly Ser Glu Val Ser Val 
                645                 650                 655     


Val Thr Val Asp Asp Met Val Thr Leu Ala Thr Glu Ala Leu Ala Ala 
            660                 665                 670         


Thr Ala Val Thr Gln Leu Thr Val Val Pro Val Gly Ala Ala Val Thr 
        675                 680                 685             


Ala Asp Glu Thr Glu Val Leu Lys Ala Glu Ile Ser Lys Ala Val Lys 
    690                 695                 700                 


Gln Val Gln Glu Glu Asp Pro Asn Thr His Ile Leu Tyr Ala Cys Asp 
705                 710                 715                 720 


Ser Cys Gly Asp Lys Phe Leu Asp Ala Asn Ser Leu Ala Gln His Val 
                725                 730                 735     


Arg Ile His Thr Ala Gln Ala Leu Val Met Phe Gln Thr Asp Ala Asp 
            740                 745                 750         


Phe Tyr Gln Gln Tyr Gly Pro Gly Gly Thr Trp Pro Ala Gly Gln Val 
        755                 760                 765             


Leu Gln Ala Gly Glu Leu Val Phe Arg Pro Arg Asp Gly Ala Glu Gly 
    770                 775                 780                 


Gln Pro Ala Leu Ala Glu Thr Ser Pro Thr Ala Pro Glu Cys Pro Pro 
785                 790                 795                 800 


Pro Ala Glu 
            


