
                                SEQUENCE LISTING

<110> Sarissa Inc.

<120> METHODS OF TREATING CANCER BY INHIBITION
  OF DNA REPAIR PROTEINS
  
  
  

<130> 753-127PR

<140> n/a                 
<141>             

<150>        
<151> 

<160> 46

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR1 gapmer

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 1
guaucucttg acgtuccuua                                             20

<210> 2
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR2 gapmer

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 2
uaccagcgag caggccgagu                                             20

<210> 3
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR3 gapmer

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 3
ugcccgatac acaaacgcug                                             20

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense

<400> 4
cagcgtttgt gtatcgggca                                             20

<210> 5
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense

<400> 5
ttggatccaa taggcat                                                17

<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense

<400> 6
tacgtactcc agaacattta a                                           21

<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense

<400> 7
ttggaggaat atcgtaggta a                                           21

<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> antisense

<400> 8
caggacacaa ttacaactaa a                                           21

<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA "A"

<400> 9
uaaauagcaa guccguuuc                                              19

<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA "B"

<400> 10
uaaugaagca ucugauacc                                              19

<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA "C"

<400> 11
uauuaaaccu gcauucuuc                                              19

<210> 12
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA "D"

<400> 12
guaucucuug acguuccuua                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> BR1 DNA

<400> 13
gtatctcttg acgttcctta                                             20

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> BR2 DNA

<400> 14
taccagcgag caggccgagt                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> BR3 DNA

<400> 15
tgcccgatac acaaacgctg                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> ODN83

<400> 16
gccagtggca acatccttaa                                             20

<210> 17
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR1 modified

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (8)...(20)
<223> 2'-O-methyl RNA

<400> 17
guaucucttg acgtuccuua                                             20

<210> 18
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR1 target

<400> 18
uaaggaacgu caagagauac                                             20

<210> 19
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR2 target

<400> 19
acucggccug cucgcuggua                                             20

<210> 20
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR2 modified

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 20
uaccagcgag caggccgagu                                             20

<210> 21
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR3 target

<400> 21
cagcguuugu guaucgggca                                             20

<210> 22
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR3 modified

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 22
ugcccgatac acaaacgcug                                             20

<210> 23
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> ODN 32 gapmer control

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<400> 23
augcgccaac ggttccuaaa                                             20

<210> 24
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> ODN491S (gapmer control)

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<400> 24
ggagugcgtg agtcgaugua                                             20

<210> 25
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> ODN83

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 25
gccaguggca acatccuuaa                                             20

<210> 26
<211> 20
<212> RNA
<213> Artifical Sequence

<220> 
<223> prior art target

<400> 26
cugcaucugc auugccauua                                             20

<210> 27
<211> 15
<212> RNA
<213> Artificial Sequence

<220> 
<223> prior art target

<400> 27
ggcuucacua auucc                                                  15

<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> prior art target

<400> 28
guaauggcaa ugcagaugc                                              19

<210> 29
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> RAD51 target

<400> 29
gaaugggucu gcacagauuc                                             20

<210> 30
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> RAD51 antisense gapmer

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 30
gaaucugtgc agacccauuc                                             20

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA-PK antisense

<400> 31
gcaagccagc tgagggcaca                                             20

<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA-PK antisense

<400> 32
gggcattcca aggcttcccc a                                           21

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA-PK antisense

<400> 33
gggctcccat ccttcccagg                                             20

<210> 34
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA-PK antisense

<400> 34
aggggccttc tcatgaccca gg                                          22

<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA-PK antisense

<400> 35
actgctggat tggcacctgc t                                           21

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA-PK antisense

<400> 36
tggggtctgt tgcctggtcc                                             20

<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA against RAD51 "A"

<400> 37
aauuucuuca caucguugg                                              19

<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA against RAD51 "B"

<400> 38
uuauccagga caucacugc                                              19

<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA against RAD51 "C"

<400> 39
ugagcuacca ccugauuag                                              19

<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA against RAD51 "D"

<400> 40
ugaugcaugg gcgaugaua                                              19

<210> 41
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR1 RNA

<400> 41
guaucucuug acguuccuua                                             20

<210> 42
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR2 RNA

<400> 42
uaccagcgag caggccgagu                                             20

<210> 43
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> BR3 RNA

<400> 43
ugcccgauac acaaacgcug                                             20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> RAD51 antisense

<400> 44
gaatctgtgc agacccattc                                             20

<210> 45
<211> 20
<212> RNA
<213> Artificial Sequence

<220> 
<223> RAD51 gapmer

<221> misc_RNA       
<222> (1)...(6)
<223> 2'-O-methyl RNA

<221> misc_feature   
<222> (7)...(14)
<223> DNA

<221> misc_RNA       
<222> (15)...(20)
<223> 2'-O-methyl RNA

<400> 45
gaaucugtgc agacccauuc                                             20

<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> BRCA2 target

<400> 46
ccgattacct gtgtaccct                                                 19

