                         SEQUENCE LISTING

<110>  UNIVERSIDAD DE NAVARRA
       INSTITUT NATIONAL DE LA SANT ET DE LA RECHERCHE MDICALE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       UNIVERSIT D'AIX-MARSEILLE
 
<120>  Modified Gram negative bacterial strains and uses thereof

<130>  P3510EP00

<150>  EP15201717.4
<151>  2015-12-21

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  1
aggtggcgac aaacgaataa                                                   20


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  2
gcccatgcca atcaaggt                                                     18


<210>  3
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
accttgattg gcatgggcag atggtcggaa gtccagatt                              39


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  4
tctgaactcg gctggatgac                                                   20


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
ttccccgggg gagaagttcg ccacagtaaa tcgaa                                  35


<210>  6
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
ttccccgggg gattaaatag atgttggcga tctt                                   34


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
gtccttatgg gaacggacgt                                                   20


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
cacagcataa ctggactgat t                                                 21


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  9
attagcttac gacgctacac cc                                                22


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
tatattctgg cgagcgatcc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
aggaagcgga acacgtagaa                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
aatcatgcga aacgatcctc                                                   20


<210>  13
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
gaggatcgtt tcgcatgatt ttcttctgag cgggactctg                             40


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
tggtccatat gaatatcctc ctta                                              24


<210>  15
<211>  259
<212>  PRT
<213>  Brucella abortus

<400>  15

Met Ala Ile Ala Pro Asn Thr Arg Val Leu Val Ala Gly Tyr Gly Leu 
1               5                   10                  15      


Pro Ala Glu Phe Cys Val Thr Thr Leu Ile Gly Met Gly Val Glu Ile 
            20                  25                  30          


Asp Lys Ile Ala Val Ala Thr His Arg Glu Asp Asn Arg Asn Cys Gly 
        35                  40                  45              


Leu His Ser Met Leu Arg Leu Arg Asn Ile Gln Phe Thr Thr Ala Ala 
    50                  55                  60                  


Ala Asn Ser Glu Glu Phe Tyr Glu Phe Gly Ala Asn Phe Asp Pro Asp 
65                  70                  75                  80  


Met Ile Ile Ser Met His Tyr Arg Ser Leu Ile Pro Gly Arg Phe Leu 
                85                  90                  95      


Lys Leu Ala Lys Lys Gly Ser Val Asn Leu His Pro Ser Leu Leu Pro 
            100                 105                 110         


Ala Tyr Arg Gly Thr Asn Ser Val Ala Trp Val Ile Ile Asn Gly Glu 
        115                 120                 125             


Ser Glu Thr Gly Phe Ser Tyr His Arg Met Asp Glu Asn Phe Asp Thr 
    130                 135                 140                 


Gly Ala Ile Leu Leu Gln Glu Arg Ile Ser Val Glu Glu Thr Asp Thr 
145                 150                 155                 160 


Ala Phe Ser Leu Phe His Arg Gln Ile Ala Arg Ala Met Leu Arg Leu 
                165                 170                 175     


Glu Glu Val Ile Leu Lys Leu Asp Gln Gly Asp Pro Gly Phe Ala Gln 
            180                 185                 190         


Leu Gly Glu Ala Ser Tyr Tyr Ala Arg Glu Leu Pro Phe Gly Gly Val 
        195                 200                 205             


Ile Asp Pro Arg Trp Ser Glu Val Gln Ile Asp Arg Phe Ile Arg Ala 
    210                 215                 220                 


Met Phe Phe Pro Pro Phe Pro Pro Ala Val Leu Lys Ile Asp Gly Lys 
225                 230                 235                 240 


Val Tyr Tyr Val Pro Ser Ile Asp Ile Tyr Arg Ser Leu Met Arg Gly 
                245                 250                 255     


Ile Pro Ser 
            


<210>  16
<211>  703
<212>  PRT
<213>  Brucella abortus

<400>  16

Met Ile Leu Pro Val Phe Val Ile Asn Met Ala Ser Gln Pro Ala Ala 
1               5                   10                  15      


Tyr Lys Thr Val Ala Ala Ser Ile Glu Ala Tyr Gly Gln Gly Phe Gln 
            20                  25                  30          


Leu His Arg Ile Asp Ala Val Asn Gly His Thr Ala Thr Gln Arg Ile 
        35                  40                  45              


Gly Ile Asp Asp Ala Arg Phe Asp Ala Ile Asn Gly Arg Glu Met Leu 
    50                  55                  60                  


Pro Gly Glu Tyr Gly Cys Tyr Arg Ser His Leu Lys Ala Leu Glu Ser 
65                  70                  75                  80  


Phe Leu Ser Asp Gly Ser Pro Tyr Gly Leu Ile Leu Glu Asp Asp Val 
                85                  90                  95      


Val Phe Thr Glu Thr Thr Ser Ala Arg Ile His Asp Ile Ile Lys Ser 
            100                 105                 110         


Leu Pro Asp Phe Asp Val Val Lys Leu Val Asn His Arg Ser Pro Leu 
        115                 120                 125             


Phe Met Ser Leu Leu Glu Thr Asp Ala Gly Asp Arg Ile Gly Arg Ala 
    130                 135                 140                 


Ile His Gly Pro Gln Gly Ser Ala Ala Ala Tyr Leu Val Ser Arg Glu 
145                 150                 155                 160 


Gly Ala Arg Lys Leu Leu Ser Ala Leu Ser Thr Met Glu Leu Pro Trp 
                165                 170                 175     


Asp Val Ala Met Glu Arg Phe Trp His His Lys Ala Arg Leu Phe Ser 
            180                 185                 190         


Ser Asp Glu Asn Ile Leu Ala Phe Ser Ser His Ser Glu Ile Ser Asn 
        195                 200                 205             


Ile Ser Asp Gln Asn Ser Gly Tyr Asp Glu Ala Lys His Pro Trp Tyr 
    210                 215                 220                 


Met Arg Leu Arg Thr Ser Leu Phe Arg Thr Phe Asp Tyr Tyr Val Arg 
225                 230                 235                 240 


Val His His Thr Leu Leu Gln Pro Gln Asn Pro Asp Gly Ser Ser Met 
                245                 250                 255     


Lys Ser Gln Ser Gly Ala Tyr Lys Leu Pro Gly Ile Ser Leu Thr Gly 
            260                 265                 270         


Glu Leu Ile Ala Ala Ile Ser Leu Leu Val Phe Met Ser Thr Val Trp 
        275                 280                 285             


Val Glu Thr Asp Ala Tyr Arg Tyr Ile Ala Leu Gly Phe Val Val Ala 
    290                 295                 300                 


Ala Leu Ile Arg Tyr Ala Arg Thr Asp Phe Trp Lys Tyr Glu Lys Pro 
305                 310                 315                 320 


Met Val Gly Trp Ala Gly Leu Leu Cys Val Ala Trp Thr Phe Tyr Val 
                325                 330                 335     


Leu Ala Arg Phe Ala Tyr Ile Tyr Leu Phe Tyr Pro Glu Met Gly Thr 
            340                 345                 350         


Gly Ser Ala Glu Gly Ile Tyr Leu Phe Pro Leu Phe Tyr Pro Thr Leu 
        355                 360                 365             


Gly Phe Ala Leu Leu Leu Phe Ile Arg Arg Pro Phe Leu Ile Ala Val 
    370                 375                 380                 


Ala Phe Met Ala Ile Ser Leu Val Ile Leu Ile Phe Gly Phe His Tyr 
385                 390                 395                 400 


Asp Leu Ser Trp Asn Glu Arg Ala Val Thr Leu Leu Gln His Asn Pro 
                405                 410                 415     


Ile His Ala Ala Val Ser Ser Gly Phe Ile Ala Leu Cys Ala Met Ala 
            420                 425                 430         


Phe Gly Ile His Thr Leu Asn Arg Asn Thr Leu Asp Thr Arg Ala Arg 
        435                 440                 445             


Val Val Leu Cys Leu Leu Ala Leu Ala Thr Phe Ile Ala Ala Leu Ile 
    450                 455                 460                 


Ala Ile Tyr Ser Leu Tyr Ser Lys Gly Val Trp Leu Ala Met Ala Ile 
465                 470                 475                 480 


Ala Phe Pro Thr Phe Val Val Leu Val Ala Leu Thr Asp Lys Ser Gln 
                485                 490                 495     


Thr Ser Arg Met Ala Ala Leu Val Cys Ile Leu Ile Gly Leu Leu Ser 
            500                 505                 510         


Val Phe Ala Gly Glu His Ile Leu Gln Arg Val Gly Gly Asn Thr Ala 
        515                 520                 525             


Asn Thr Ser Trp Glu Leu Leu Ser Asp Leu Lys Thr Gly Asp Asn Ile 
    530                 535                 540                 


Met Gln Asp Phe Asp Lys Ala Ile Lys Asn Pro Glu Thr Gly Leu Ser 
545                 550                 555                 560 


Glu Arg Glu Arg Leu Met Ile Trp Ala Asn Thr Leu His Ile Trp His 
                565                 570                 575     


Lys Asn Pro Ile Phe Gly Ala Gly Val Ser Trp Leu His Tyr Trp Glu 
            580                 585                 590         


Lys Arg Pro Tyr Gln Gln Thr Asp Phe Thr Leu Leu His Asn Gly Tyr 
        595                 600                 605             


Leu Glu Ile Ala Ile Arg Tyr Gly Phe Leu Gly Leu Leu Phe Tyr Gly 
    610                 615                 620                 


Val Leu Thr Val Trp Ala Val Arg Cys Thr Trp Gln Ala Thr Arg Ala 
625                 630                 635                 640 


Gly Leu Ile Asp Ser Ala Ala Phe Gln Cys Tyr Val Ala Thr Leu Val 
                645                 650                 655     


Phe Phe Ala Val Thr Ile Leu Ser Asn Ser Asn Val Arg Leu Ala Ile 
            660                 665                 670         


Gly Glu Ser Tyr Met Ala Leu Ala Phe Gly Phe Ala Phe Tyr Cys Gln 
        675                 680                 685             


Tyr Leu Leu Gln Gln His Asn Arg Gln Tyr Pro Arg Thr Tyr Phe 
    690                 695                 700             


<210>  17
<211>  239
<212>  PRT
<213>  Brucella abortus

<400>  17

Met Asn Val Lys Ala Phe Ile Ile His Leu Lys Arg Ala Thr Asp Arg 
1               5                   10                  15      


Ala Pro Gln Val Glu Lys Leu Ile Lys Glu Leu Pro Val Lys Ala Glu 
            20                  25                  30          


Val Ile Glu Ala Val Asp Ser Arg Ala Leu Asn Lys Asp Glu Ile Ala 
        35                  40                  45              


Arg Ile Tyr Lys Arg Arg Leu His Thr Pro Arg Tyr Pro Phe Ala Leu 
    50                  55                  60                  


Ser Arg Asn Glu Ile Ala Cys Phe Leu Ser His Arg Lys Ala Trp Gln 
65                  70                  75                  80  


Ala Ile Ile Asp Arg Lys Leu Asp Ala Gly Phe Ile Val Glu Asp Asp 
                85                  90                  95      


Ile Ala Leu Thr Glu Asn Phe Met Gly Ala Tyr Arg Ala Ala Val Asp 
            100                 105                 110         


His Leu Glu Pro Gly Gly Phe Ile Arg Phe Thr Phe Arg Asp Asp Arg 
        115                 120                 125             


Glu His Gly Arg Glu Val Phe Arg Asp Glu Ala Val Arg Ile Ile Ile 
    130                 135                 140                 


Pro Asn Pro Ile Gly Leu Gly Met Val Ala Gln Phe Val Ser Tyr Asp 
145                 150                 155                 160 


Ala Ala Gln Lys Leu Leu Asp Ile Thr Gln Thr Phe Asp Arg Pro Val 
                165                 170                 175     


Asp Thr Thr Val Gln Met Arg Trp Val Thr Gly Leu Gln Pro Leu Ser 
            180                 185                 190         


Val Ile Pro Gly Gly Val Lys Glu Ile Ser Ser Gln Leu Gly Gly Thr 
        195                 200                 205             


Thr Ile Gln His Lys Lys Asn Phe Ser Asp Lys Leu Ala Arg Glu Ile 
    210                 215                 220                 


Leu Arg Pro Ile Tyr Arg Met Arg Val Arg Ala Tyr Ser Ser Lys 
225                 230                 235                 


<210>  18
<211>  354
<212>  PRT
<213>  Brucella abortus

<400>  18

Met Thr Leu Ser Gly Gln Val Pro Val Arg Glu Val Glu Val Val Ala 
1               5                   10                  15      


Pro Asn Phe Lys Arg Arg Leu Ser Gly Val Thr Ser Thr Ile Val Gln 
            20                  25                  30          


Leu Ile Pro Leu Gln Arg Ala Met Gly Leu Lys Ile Ala Thr Met Gly 
        35                  40                  45              


Pro Gly Leu Pro Asp Thr Leu Pro His Leu Gly Trp Ser Ala Leu Pro 
    50                  55                  60                  


Ser Phe Trp Ser Arg Pro Lys Thr Arg Arg Phe Arg Ile Trp His Ala 
65                  70                  75                  80  


Arg Arg Asn Ile Glu Met Leu Ala Gly Ile Phe Met Arg Asp Val Leu 
                85                  90                  95      


Arg Met Lys Leu Arg Leu Val Phe Thr Ser Ala Ala Gln Arg His His 
            100                 105                 110         


Lys Pro Phe Thr Lys Trp Leu Ile Arg Arg Met Asn Ala Val Ile Ala 
        115                 120                 125             


Thr Ser Val Arg Ser Gly Ser Phe Leu Glu Val Pro His Gln Val Ile 
    130                 135                 140                 


Met His Gly Val Asp Leu Glu Arg Phe His Pro Pro Leu Ala Glu Asp 
145                 150                 155                 160 


Asp Asp Phe Ser Ala Ser Gly Leu Pro Gly Lys Tyr Ala Val Gly Cys 
                165                 170                 175     


Phe Gly Arg Val Arg Pro Ser Lys Gly Thr Asp Leu Phe Val Asp Ala 
            180                 185                 190         


Met Ile Ala Leu Leu Pro Lys Tyr Pro Asp Trp Thr Ala Ile Val Thr 
        195                 200                 205             


Gly Arg Thr Thr Ala Glu Tyr Gln Ala Phe Glu Ala Glu Leu Arg Thr 
    210                 215                 220                 


Arg Ile Ala Ala Ala Gly Leu Gln Asp Arg Ile Leu Ile Leu Gly Glu 
225                 230                 235                 240 


Val Pro Asp Val Arg Val Trp Tyr Arg Arg Leu Thr Leu Tyr Val Ala 
                245                 250                 255     


Pro Ser Arg Asn Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala 
            260                 265                 270         


Ser Lys Thr Ala Val Val Ala Ser Asp Ala Gly Ala Tyr Ala Glu Met 
        275                 280                 285             


Val Val Glu Asp Thr Gly Arg Phe Val Pro Ala Gly Asp Gly Arg Ala 
    290                 295                 300                 


Leu Thr Asn Ala Ile Glu Pro Tyr Leu Ala Asp Pro Ala Met Thr Lys 
305                 310                 315                 320 


Arg Cys Gly Glu Asn Ala Leu Ala His Val Arg Glu Ala Phe Pro Leu 
                325                 330                 335     


Gln Lys Glu Ala Ala Ala Ile Ser Ser Val Tyr Glu Gln Val Phe Ala 
            340                 345                 350         


Gly Arg 
        


<210>  19
<211>  323
<212>  PRT
<213>  Brucella abortus

<400>  19

Met Pro Ile Phe Lys Ile Ile Ile Ala Thr Thr Thr Arg Asn Arg Pro 
1               5                   10                  15      


Lys Met Leu Ile Asn Leu Tyr Lys Ser Leu Gly Asp Leu Glu Ile Pro 
            20                  25                  30          


Ser Asn Ile Asp Val Glu Phe Leu Ile Val Glu Asn Asn Arg Thr Ser 
        35                  40                  45              


Thr Ser Glu Ser Trp Leu His Glu Ile Arg Ser Ser Ile Ser Pro Ser 
    50                  55                  60                  


Ala Val Val Tyr Ile Leu Glu Thr Ser Ile Gly Ile Ser Cys Ala Arg 
65                  70                  75                  80  


Asn Arg Ala Leu Asp Tyr Ala Gln Glu Ala Gly Ala Asp Phe Leu Ala 
                85                  90                  95      


Phe Val Asp Asp Asp Glu Phe Val Glu Pro Asp Trp Leu Lys Gln Leu 
            100                 105                 110         


Phe Ala Glu Gln Gln Arg Arg Asp Leu Asp Leu Val Gly Ser Pro Val 
        115                 120                 125             


Arg Pro Val Pro Gln Asn Ser Lys Leu Ser Leu Trp Gln Arg Phe Val 
    130                 135                 140                 


Trp Ser Gly Val Glu Arg Asn Gly Thr Arg Ala Glu Asp Arg Ala Arg 
145                 150                 155                 160 


Arg Lys Trp Gln Glu Asn Lys Ala Asp Thr Ile Lys Ile Ala Thr Gly 
                165                 170                 175     


Ser Trp Leu Gly Arg Ile Asp Phe Phe Arg Arg Thr Gly Leu Arg Phe 
            180                 185                 190         


Asp Ser Lys Leu Gly Leu Thr Gly Gly Glu Asp Trp Asn Leu Trp Leu 
        195                 200                 205             


Glu Ala Lys Lys Leu Gly Ala Lys Thr Gly Trp Ala Pro Asp Ala Ile 
    210                 215                 220                 


Val Tyr Glu Thr Val Pro Tyr Cys Arg Ile Ser Phe Ser Tyr His Phe 
225                 230                 235                 240 


Arg Arg Asn Arg Asp His Asn Ala Thr Glu Phe Thr Leu Leu Tyr Ser 
                245                 250                 255     


Lys Ser Pro Arg Arg Ala Trp Met Arg Leu Pro Ser Arg Ile Leu Ser 
            260                 265                 270         


Arg Val Trp Lys Leu Leu Thr Ala Ile Leu Thr Leu Pro Phe Lys Gly 
        275                 280                 285             


Gly Gln Ala Leu Ile Ser Leu Ala Met Ala Leu Gly Gly Ile Val Gly 
    290                 295                 300                 


Leu Val Gln Ala Cys Cys Gly Lys Gln Gln Leu His Tyr Lys Glu Thr 
305                 310                 315                 320 


Thr Gly Ser 
            


<210>  20
<211>  260
<212>  PRT
<213>  Brucella abortus

<400>  20

Met Ile Ser Tyr Met Ala Asn Val Trp Lys Val Arg His Phe Trp Trp 
1               5                   10                  15      


His Leu Ser Met Ser Asp Leu Arg Gly Arg Phe Arg Arg Ser Ser Leu 
            20                  25                  30          


Gly Ile Leu Trp Ala Val Ile Gln Pro Leu Ala Leu Thr Leu Leu Leu 
        35                  40                  45              


Ser Phe Val Phe Ser Lys Leu Leu Asn Gln Ser Ile Ser Ala Tyr Ala 
    50                  55                  60                  


Pro Tyr Ile Leu Ser Gly Ile Ile Ile Trp Glu Tyr Ile Ser Phe Thr 
65                  70                  75                  80  


Val Val Gly Gly Ser Thr Ala Leu Val Gln Ala Asp Ala Tyr Ile Lys 
                85                  90                  95      


Gln Thr Arg Asn Pro Leu Ala Ile Tyr Thr Leu Arg Asn Thr Val Ser 
            100                 105                 110         


Gly Leu Val Val Leu Ser Val Ala Ser Ile Ser Leu Phe Gly Trp Val 
        115                 120                 125             


Leu Ile Met Phe Pro Glu Asn Phe Ser Leu Ser Trp Leu Ala Ile Pro 
    130                 135                 140                 


Thr Leu Pro Pro Ile Leu Ala Leu Ile Val Trp Pro Leu Ala Thr Ile 
145                 150                 155                 160 


Val Gly Tyr Ile Gly Ala Arg Phe Arg Asp Leu Pro Asn Ala Leu Ala 
                165                 170                 175     


Leu Val Leu Gln Ala Ala Trp Phe Val Ser Pro Val Tyr Phe Lys Glu 
            180                 185                 190         


Ser Met Phe Arg Gln Gly Gly Leu Asn Ala Phe Val Asp Tyr Asn Pro 
        195                 200                 205             


Ile Tyr His Val Met Gln Ile Leu Arg Ala Pro Val Leu Tyr Gly Glu 
    210                 215                 220                 


Trp Pro Thr Ala Thr Asn Tyr Ile Trp Cys Leu Gly Val Ser Leu Leu 
225                 230                 235                 240 


Leu Thr Cys Val Ala Val Ala Val Gly Met Arg Ala Glu Lys Arg Ala 
                245                 250                 255     


Ile Phe Tyr Leu 
            260 


<210>  21
<211>  252
<212>  PRT
<213>  Brucella abortus

<400>  21

Met Ile Gln Pro Ser Ile Thr Leu Ser Asn Val His Leu His Tyr Ala 
1               5                   10                  15      


Ala Ser Ala Phe Lys Glu Arg Ser Val Lys Thr Leu Val Asn Ala Leu 
            20                  25                  30          


Leu Ser Met Arg Arg Ser Ala Gly Ala Asn Ile Glu Asp Ile His Ala 
        35                  40                  45              


Leu Lys Gly Ile Ser Val Asp Ile Ala Arg Gly Glu Arg Val Ala Leu 
    50                  55                  60                  


Ile Gly His Asn Gly Ala Gly Lys Ser Thr Phe Leu Lys Thr Ile Ala 
65                  70                  75                  80  


Gly Leu Tyr Pro Ile Ser Ser Gly Thr Leu Lys Val Thr Gly Thr Val 
                85                  90                  95      


Arg Ser Leu Phe Asp Ile Gly Leu Gly Phe Glu Pro Asp Ala Thr Gly 
            100                 105                 110         


Arg Glu Asn Ile Leu Tyr Arg Gly Leu Leu Leu Gly Leu Thr Pro Arg 
        115                 120                 125             


Phe Met Arg Glu Ile Glu Asp Glu Ile Ile Glu Phe Ala Asp Leu Gly 
    130                 135                 140                 


Asp Phe Ile Asp Tyr Pro Ile Lys Thr Tyr Ser Ala Gly Met Gln Val 
145                 150                 155                 160 


Arg Leu Ala Phe Ala Ile Ser Thr Ala Val Ala Gly Asp Ile Leu Leu 
                165                 170                 175     


Leu Asp Glu Val Ile Gly Ala Gly Asp Ala Ala Phe Met Thr Lys Ala 
            180                 185                 190         


Lys Ala Arg Ile Met Asn Met Val Glu Lys Ala Glu Ile Met Val Leu 
        195                 200                 205             


Ala Ser His Asp Leu Ala Asn Val Arg Gln Leu Cys Thr Arg Ala Leu 
    210                 215                 220                 


Val Phe Lys Ala Gly Thr Ile Ala Phe Asp Gly Arg Val Glu Asp Ala 
225                 230                 235                 240 


Ile Ser Phe Tyr Asn Ser Gly Met Gly Ala Ile Ala 
                245                 250         


<210>  22
<211>  335
<212>  PRT
<213>  Brucella abortus

<400>  22

Met Arg Phe Leu Leu Val Ser Phe Phe Val Ser Ala Leu Leu Cys Gly 
1               5                   10                  15      


Ile Gly Leu Phe Leu Leu Ser His Leu Leu Pro Ala Asn Phe Leu Ala 
            20                  25                  30          


Ala Arg Met Ser Ser Arg Ser Asn His Ser Ile Ala Ala Arg Gln Ile 
        35                  40                  45              


Gly Gly Leu Ala Leu Ile Pro Ala Ile Leu Val Thr Leu Ala Ile Phe 
    50                  55                  60                  


Ala Pro Asp Leu Glu Val Asn Met Gln Leu Phe Leu Cys Leu Ser Gly 
65                  70                  75                  80  


Ala Ser Leu Leu Leu Trp Val Val Gly Gly Leu Asp Asp Arg Tyr Glu 
                85                  90                  95      


Leu Ser Glu Ile Ile Arg Leu Gly Ser Gln Leu Leu Ala Ala Ile Thr 
            100                 105                 110         


Val Leu Tyr Gly Leu Gly Pro Asp Phe Arg Leu Leu Pro Asn Leu Leu 
        115                 120                 125             


Pro Tyr Trp Leu Glu Ala Thr Leu Ile Val Phe Ala Leu Ile Ile Ala 
    130                 135                 140                 


Ile Asn Val Thr Asn Phe Met Asp Gly Leu Asp Leu Met Thr Val Ala 
145                 150                 155                 160 


Gly Leu Gly Val Pro Leu Val Gly Ile Ala Leu Leu Gly Ala Leu Gly 
                165                 170                 175     


Leu Thr Gly Leu Thr Ser Ser Gly Ile Gly Ala Val Ala Ala Gly Gly 
            180                 185                 190         


Leu Leu Gly Phe Ala Leu Phe Asn Arg Pro Pro Ala Ser Ile Phe Leu 
        195                 200                 205             


Gly Asp Ser Gly Ser Pro Pro Leu Gly Leu Ile Val Gly Thr Ala Leu 
    210                 215                 220                 


Leu Leu Leu Ala Arg Glu Thr His Ile Val Val Ala Leu Val Leu Pro 
225                 230                 235                 240 


Leu Tyr Tyr Ile Leu Asp Ala Gly Thr Thr Ile Val Met Arg Ala Ala 
                245                 250                 255     


Gln Gly Glu Asn Ile Leu Lys Ala His Ser Lys His Ala Tyr Gln Ile 
            260                 265                 270         


Ala Lys Arg Ser Gly Trp Ser Val Pro Lys Val Val Ala His Val Ala 
        275                 280                 285             


Leu Leu Asn Thr Ile Leu Ile Ala Cys Val Val Ala Leu Leu Ala Leu 
    290                 295                 300                 


Asp His Pro Leu Ala Gln Leu Thr Phe Leu Leu Val Ala Ala Val Ala 
305                 310                 315                 320 


Thr Leu Ile Leu Leu Leu Asp Phe Arg Gly Arg Phe Arg Lys Leu 
                325                 330                 335 


<210>  23
<211>  887
<212>  PRT
<213>  Brucella abortus

<400>  23

Met Ala Lys Trp Val Tyr Thr Phe Gly Asp Gly Lys Ala Glu Gly Ala 
1               5                   10                  15      


Ala Ser Asp Arg Asn Leu Leu Gly Gly Lys Gly Ala Asn Leu Ala Glu 
            20                  25                  30          


Met Ser Ser Leu Gly Leu Pro Val Pro Pro Gly Phe Thr Ile Thr Thr 
        35                  40                  45              


Glu Val Cys Thr Tyr Tyr Tyr Asn Asn Asp Arg Val Tyr Pro Ser Glu 
    50                  55                  60                  


Leu Asp Ala Gln Val Gln Ala Ala Leu Ala His Ile Ala Thr Leu Thr 
65                  70                  75                  80  


Gly Arg Asn Phe Gly Asp Ala Glu Lys Pro Leu Leu Val Ser Val Arg 
                85                  90                  95      


Ser Gly Ala Arg Ala Ser Met Pro Gly Met Met Asp Thr Val Leu Asn 
            100                 105                 110         


Leu Gly Leu Asn Asp Glu Thr Val Gln Ala Ile Ala Arg Glu Ser Gly 
        115                 120                 125             


Asp Glu Arg Phe Ala Tyr Asp Ser Tyr Arg Arg Phe Ile Gln Met Tyr 
    130                 135                 140                 


Ser Asp Val Val Leu Gly Val Asp His Gly Phe Phe Glu Glu Ile Leu 
145                 150                 155                 160 


Glu Asp Thr Lys Ala Asp Leu Gly Val Glu Val Asp Thr Ala Leu Ser 
                165                 170                 175     


Ala Asp Asp Trp Lys Asn Val Ile Gly Leu Tyr Lys Ala Lys Val Glu 
            180                 185                 190         


Glu Glu Leu Gly Gln Pro Phe Pro Gln Asp Pro Arg Glu Gln Leu Trp 
        195                 200                 205             


Gly Ala Ile Gly Ala Val Phe Ser Ser Trp Met Asn Ala Arg Ala Ile 
    210                 215                 220                 


Thr Tyr Arg Arg Leu His Asn Ile Pro Ala Ala Trp Gly Thr Ala Val 
225                 230                 235                 240 


Asn Val Gln Ala Met Val Phe Gly Asn Met Gly Glu Thr Ser Ala Thr 
                245                 250                 255     


Gly Val Ala Phe Thr Arg Asn Pro Ser Thr Gly Glu Asn Lys Leu Tyr 
            260                 265                 270         


Gly Glu Phe Leu Val Asn Ala Gln Gly Glu Asp Val Val Ala Gly Ile 
        275                 280                 285             


Arg Thr Pro Gln Asn Ile Thr Glu Glu Ala Arg Ile Ala Ala Gly Ser 
    290                 295                 300                 


Asp Lys Pro Ser Leu Glu Lys Val Met Pro Glu Ala Phe Ala Glu Phe 
305                 310                 315                 320 


Leu Lys Val Ala Asn Arg Leu Glu Gln His Tyr Arg Asp Met Gln Asp 
                325                 330                 335     


Leu Glu Phe Thr Ile Glu Arg Gly Lys Leu Trp Met Leu Gln Thr Arg 
            340                 345                 350         


Ser Gly Lys Arg Thr Ala Arg Ala Ala Leu Lys Met Ala Val Glu Met 
        355                 360                 365             


Ala Ala Glu Gly Leu Ile Ser Glu Glu Glu Ala Val Leu Arg Ile Asp 
    370                 375                 380                 


Pro Ala Ala Leu Asp Gln Leu Leu His Pro Thr Ile Asp Pro Arg Ala 
385                 390                 395                 400 


Glu Arg Gln Val Val Gly Met Gly Leu Pro Ala Ser Pro Gly Ala Ala 
                405                 410                 415     


Thr Gly Glu Ile Val Phe Ser Ser Glu Glu Ala Glu Gln Ala Lys Ala 
            420                 425                 430         


Glu Gly Arg Asn Val Ile Leu Val Arg Ile Glu Thr Ser Pro Glu Asp 
        435                 440                 445             


Ile His Gly Met His Ala Ala Glu Gly Ile Leu Thr Thr Arg Gly Gly 
    450                 455                 460                 


Met Thr Ser His Ala Ala Val Val Ala Arg Gly Met Gly Lys Pro Cys 
465                 470                 475                 480 


Val Ser Gly Ala Gly Ser Leu Arg Val Asp Tyr Arg Asn Gly Thr Met 
                485                 490                 495     


Leu Ala Ala Gly Gln Thr Phe Arg Lys Gly Asp Val Ile Thr Ile Asp 
            500                 505                 510         


Gly Ala Ser Gly Gln Val Leu Lys Gly Ser Val Ala Met Leu Gln Pro 
        515                 520                 525             


Glu Leu Ser Gly Asp Phe Gly Lys Leu Met Glu Trp Ala Asp Arg Ala 
    530                 535                 540                 


Arg Arg Met Lys Val Arg Ala Asn Ala Glu Thr Pro Ala Asp Ala Arg 
545                 550                 555                 560 


Thr Ala Arg Ser Phe Gly Ala Glu Gly Ile Gly Leu Cys Arg Thr Glu 
                565                 570                 575     


His Met Phe Phe Asp Gly Ser Arg Ile Val Ala Met Arg Glu Met Ile 
            580                 585                 590         


Leu Ser Asp Thr Glu Glu Gly Arg Arg Leu Ala Leu Gly Lys Leu Leu 
        595                 600                 605             


Pro Met Gln Arg Ser Asp Phe Ala Glu Leu Phe Glu Ile Met Lys Gly 
    610                 615                 620                 


Leu Pro Val Thr Ile Arg Leu Leu Asp Pro Pro Leu His Glu Phe Leu 
625                 630                 635                 640 


Pro His Thr Asp Glu Glu Val Asp Glu Val Ala Arg Ser Met Gly Val 
                645                 650                 655     


Asp Ala Ala Lys Leu Arg Asp Arg Ala Asp Ala Leu His Glu Phe Asn 
            660                 665                 670         


Pro Met Leu Gly His Arg Gly Cys Arg Leu Ala Val Ser Tyr Pro Glu 
        675                 680                 685             


Ile Ala Glu Met Gln Ala Arg Ala Ile Phe Glu Ala Ala Val Glu Ala 
    690                 695                 700                 


Gly Lys Lys Thr Gly Glu Pro Val Val Pro Glu Val Met Val Pro Leu 
705                 710                 715                 720 


Val Gly Leu Lys Ala Glu Leu Asp Phe Val Lys Ala Arg Ile Asp Ala 
                725                 730                 735     


Val Ala Lys Glu Val Met Ser Glu Ala Gly Ile Lys Ile Asp Tyr Met 
            740                 745                 750         


Val Gly Thr Met Ile Glu Leu Pro Arg Ala Ala Leu Arg Ala Ala Glu 
        755                 760                 765             


Ile Ala Glu Ser Ala Glu Phe Phe Ser Phe Gly Thr Asn Asp Leu Thr 
    770                 775                 780                 


Gln Thr Thr Phe Gly Ile Ser Arg Asp Asp Ala Ala Gly Phe Leu Thr 
785                 790                 795                 800 


Thr Tyr Gln Asn Arg Gly Val Ile Glu Gln Asp Pro Phe Val Ser Leu 
                805                 810                 815     


Asp Val Asp Gly Val Gly Glu Leu Val Gln Ile Ala Ala Glu Arg Gly 
            820                 825                 830         


Arg Lys Thr Arg Glu Lys Ile Lys Leu Gly Ile Cys Gly Glu His Gly 
        835                 840                 845             


Gly Asp Pro Ala Ser Ile Ala Phe Cys Glu Lys Thr Gly Leu Asp Tyr 
    850                 855                 860                 


Val Ser Cys Ser Pro Phe Arg Val Pro Ile Ala Arg Leu Ala Ala Ala 
865                 870                 875                 880 


Gln Ala Ala Val Arg Lys Val 
                885         


<210>  24
<211>  774
<212>  PRT
<213>  Brucella abortus

<400>  24

Met Thr Lys Lys Pro Ser Ser Pro Ser Thr Arg Ser Asp Phe Asp Glu 
1               5                   10                  15      


Ala Ala Leu Phe Phe His Arg Tyr Pro Lys Pro Gly Lys Leu Glu Ile 
            20                  25                  30          


Gln Ala Thr Lys Pro Leu Gly Asn Gln Arg Asp Leu Ala Leu Ala Tyr 
        35                  40                  45              


Ser Pro Gly Val Ala Ala Pro Cys Leu Ala Ile His Asp Asp Pro Ala 
    50                  55                  60                  


Thr Ala Ala Glu Tyr Thr Ala Arg Gly Asn Leu Val Ala Val Val Ser 
65                  70                  75                  80  


Asn Gly Thr Ala Val Leu Gly Leu Gly Asn Ile Gly Ala Leu Ala Ser 
                85                  90                  95      


Lys Pro Val Met Glu Gly Lys Ala Val Leu Phe Lys Lys Phe Ala Asp 
            100                 105                 110         


Ile Asp Val Phe Asp Ile Glu Ile Asp Ala His Glu Ile Asn Arg Ile 
        115                 120                 125             


Val Asp Val Val Ser Ala Leu Glu Pro Thr Phe Gly Gly Ile Asn Leu 
    130                 135                 140                 


Glu Asp Ile Lys Ala Pro Glu Cys Phe Glu Val Glu Glu Gln Leu Arg 
145                 150                 155                 160 


Glu Arg Met Asn Ile Pro Val Phe His Asp Asp Gln His Gly Thr Ala 
                165                 170                 175     


Ile Ile Val Ala Ser Ala Val Leu Asn Gly Leu Glu Leu Ala Gly Lys 
            180                 185                 190         


Lys Ile Glu Glu Ala Lys Ile Val Thr Ser Gly Ala Gly Ala Ala Ala 
        195                 200                 205             


Leu Ala Cys Leu Asn Leu Leu Val Asn Leu Gly Ala Lys Arg Glu Asn 
    210                 215                 220                 


Ile Trp Val Cys Asp Ile Glu Gly Val Val Tyr Asp Gly Arg Asn Thr 
225                 230                 235                 240 


Leu Met Asp Arg Trp Lys Glu Val Tyr Ala Gln Lys Thr Asp Ala Arg 
                245                 250                 255     


Thr Leu Ala Asp Val Ile Gly Gly Ala Asp Val Phe Leu Gly Leu Ser 
            260                 265                 270         


Ala Ala Gly Val Leu Lys Pro Glu Leu Leu Lys Gln Met Ala Glu Lys 
        275                 280                 285             


Pro Leu Ile Met Ala Leu Ala Asn Pro Lys Pro Glu Ile Met Pro Glu 
    290                 295                 300                 


Glu Ala Arg Ala Ala Arg Ala Asp Ala Met Ile Cys Thr Gly Arg Ser 
305                 310                 315                 320 


Asp Phe Pro Asn Gln Val Asn Asn Val Leu Cys Phe Pro Tyr Ile Phe 
                325                 330                 335     


Arg Gly Ala Leu Asp Val Gly Ala Thr Val Ile Asn Glu Glu Met Lys 
            340                 345                 350         


Leu Ala Ala Val Arg Ala Ile Ala Ser Leu Ala Arg Glu Glu Pro Ser 
        355                 360                 365             


Asp Val Ala Ala Arg Ala Tyr Ser Gly Asp Thr Pro Thr Phe Gly Pro 
    370                 375                 380                 


Asp Tyr Ile Ile Pro Ser Pro Phe Asp Gln Arg Leu Ile Leu Arg Ile 
385                 390                 395                 400 


Ala Pro Ala Val Ala Lys Ala Ala Met Glu Thr Gly Val Ala Thr Arg 
                405                 410                 415     


Pro Ile Glu Asp Met Glu Ala Tyr Leu Asp Arg Leu Asn Arg Phe Val 
            420                 425                 430         


Phe Arg Ser Gly Leu Ile Met Lys Pro Val Phe Ala Ala Ala Arg Thr 
        435                 440                 445             


Gln Gly Ala Pro Met Arg Val Ile Tyr Ala Asp Gly Glu Asp Glu Arg 
    450                 455                 460                 


Val Leu Arg Ala Ala Gln Val Val Ile Glu Glu Arg Ile Ala Ala Pro 
465                 470                 475                 480 


Ile Leu Val Gly Arg Pro Gln Val Val Glu Thr Arg Leu Arg Arg Tyr 
                485                 490                 495     


Gly Leu Lys Ile Arg Pro Gly Thr Asp Phe Glu Leu Ile Asn Pro Glu 
            500                 505                 510         


Asp Asp Pro Arg Tyr Arg Asp Tyr Val Asp Leu Tyr Leu Ser Tyr Thr 
        515                 520                 525             


Gly Arg Gln Gly Val Thr Pro Glu Ala Ala Arg Thr Ile Val Arg Thr 
    530                 535                 540                 


Asn Ser Thr Ala Ile Ala Ala Leu Ala Val Met Arg Asp Glu Ala Asp 
545                 550                 555                 560 


Ala Met Ile Cys Gly Leu Glu Gly Arg Phe Glu Arg His Leu Arg Val 
                565                 570                 575     


Val Arg Gln Ile Ile Gly Lys Val Pro Gly Ile Arg Asp Tyr Ser Ala 
            580                 585                 590         


Leu Ser Leu Leu Ile Ser Gln Arg Gly Ala Leu Phe Leu Thr Asp Thr 
        595                 600                 605             


Tyr Val Asn Ala Glu Pro Asp Ala Asn Glu Ile Ala Glu Met Ala Val 
    610                 615                 620                 


Leu Ala Ala Arg Glu Ile Ser Arg Phe Gly Ile Glu Pro Lys Ala Ala 
625                 630                 635                 640 


Leu Val Ser His Ser Asn Phe Gly Ser Lys Glu Ser Ala Ser Ala Glu 
                645                 650                 655     


Lys Met Arg Gln Ala Ala Ala Ile Leu Ala Glu Lys Ala Pro Asp Leu 
            660                 665                 670         


Glu Ser Asp Gly Glu Met His Gly Asp Ala Ala Leu Ser Gln Thr Leu 
        675                 680                 685             


Arg Asp Arg Val Phe Pro Ser Ser Arg Leu Lys Gly Glu Ala Asn Leu 
    690                 695                 700                 


Leu Val Phe Pro Asn Leu Asp Ala Ala Asn Ile Thr Leu Asn Val Val 
705                 710                 715                 720 


Lys Ala Val Thr Asp Ala Leu His Val Gly Pro Ile Leu Leu Gly Ala 
                725                 730                 735     


Thr Arg Pro Ala His Ile Leu Thr Pro Ser Val Thr Ser Arg Gly Val 
            740                 745                 750         


Val Asn Met Thr Ala Leu Ala Val Val Glu Ala Leu Gln Lys Asn Ala 
        755                 760                 765             


Ser Asn Arg Arg Gln Lys 
    770                 


<210>  25
<211>  354
<212>  PRT
<213>  Brucella abortus

<400>  25

Met Ala Arg Ile Thr Leu Arg Gln Leu Leu Asp His Ala Ala Glu Lys 
1               5                   10                  15      


Gly Tyr Gly Val Pro Ala Phe Asn Ile Asn Asn Met Glu Gln Ala Leu 
            20                  25                  30          


Ala Ile Met Glu Ala Ala Asn Ala Val Asp Ala Pro Val Ile Leu Gln 
        35                  40                  45              


Ala Ser Arg Gly Ala Arg Ser Tyr Ala Asn Asp Ile Met Leu Arg His 
    50                  55                  60                  


Met Met Asp Ala Val Ala Glu Ile Tyr Pro His Ile Pro Val Cys Val 
65                  70                  75                  80  


His Leu Asp His Gly Asn Glu Ala Ala Thr Cys Met Ser Ala Ile Gln 
                85                  90                  95      


Ala Gly Phe Thr Ser Val Met Met Asp Gly Ser Leu Lys Ala Asp Gly 
            100                 105                 110         


Lys Thr Pro Ala Asp Trp Asp Tyr Asn Val Ser Val Thr Arg Gln Val 
        115                 120                 125             


Ser Glu Met Ser His Leu Gly Gly Ile Ser Val Glu Gly Glu Leu Gly 
    130                 135                 140                 


Val Leu Gly Ser Leu Glu Thr Gly Met Gly Asp Val Glu Asp Gly His 
145                 150                 155                 160 


Gly Ala Glu Gly Lys Leu Ser His Asp Gln Leu Leu Thr Asp Pro Asp 
                165                 170                 175     


Glu Ala Val Lys Phe Val Arg Glu Thr Lys Val Asp Ala Leu Ala Ile 
            180                 185                 190         


Ala Met Gly Thr Ser His Gly Ala Tyr Lys Phe Ser Arg Lys Pro Asp 
        195                 200                 205             


Gly Ser Val Leu Ala Met His Val Ile Glu Glu Ile His Arg Lys Leu 
    210                 215                 220                 


Pro Asn Thr His Leu Val Met His Gly Ser Ser Ser Val Pro Glu Glu 
225                 230                 235                 240 


Leu Gln Glu Ile Ile Asn Lys Tyr Gly Gly Gln Met Lys Pro Thr Trp 
                245                 250                 255     


Gly Val Pro Val Glu Glu Ile Gln Arg Gly Ile Lys His Gly Val Arg 
            260                 265                 270         


Lys Ile Asn Ile Asp Thr Asp Asn Arg Met Ala Met Thr Gly Gln Ile 
        275                 280                 285             


Arg Arg Ile Leu Gln Glu Glu Pro Ser Glu Phe Asp Pro Arg Lys Tyr 
    290                 295                 300                 


Leu Lys Pro Ala Met Ala Ala Met Thr Lys Leu Cys Lys Glu Arg Phe 
305                 310                 315                 320 


Glu Gln Phe Gly Thr Ala Gly His Ala Ala Ser Ile Arg Pro Ile Pro 
                325                 330                 335     


Leu Ser Glu Met Ala Lys Arg Tyr Arg Asp Gly Ser Leu Asp Pro Lys 
            340                 345                 350         


Phe Ser 
        


<210>  26
<211>  151
<212>  PRT
<213>  Brucella abortus

<400>  26

Met Lys Val Ala Val Ala Gly Asp Ser Ala Gly Glu Gly Leu Ala Lys 
1               5                   10                  15      


Val Leu Ala Asp His Leu Lys Asp Arg Phe Glu Val Ser Glu Ile Ser 
            20                  25                  30          


Arg Thr Asp Ala Gly Ala Asp Ala Phe Tyr Ala Asn Leu Ser Asp Arg 
        35                  40                  45              


Val Ala Ser Ala Val Leu Asp Gly Thr Tyr Asp Arg Ala Ile Leu Val 
    50                  55                  60                  


Cys Gly Thr Gly Ile Gly Val Cys Ile Ala Ala Asn Lys Val Pro Gly 
65                  70                  75                  80  


Ile Arg Ala Ala Leu Thr His Asp Thr Tyr Ser Ala Glu Arg Ala Ala 
                85                  90                  95      


Leu Ser Asn Asn Ala Gln Ile Ile Thr Met Gly Ala Arg Val Ile Gly 
            100                 105                 110         


Ala Glu Val Ala Lys Thr Ile Ala Asp Ala Phe Leu Ala Gln Thr Phe 
        115                 120                 125             


Asp Glu Asn Gly Arg Ser Ala Gly Asn Val Asn Ala Ile Asn Glu Val 
    130                 135                 140                 


Asp Ala Lys Tyr Asn Lys Phe 
145                 150     


<210>  27
<211>  517
<212>  PRT
<213>  Brucella abortus

<400>  27

Met Arg Glu Lys Gly Asp Ile Ile Ile Gly Ile Asp Ala Gly Thr Ser 
1               5                   10                  15      


Val Leu Lys Ala Val Ala Phe Asp Phe Ser Gly Arg Gln Ile Glu Ser 
            20                  25                  30          


Ala Ala Val Arg Asn Thr Tyr Val Thr Gly Asp His Gly Ala Val Thr 
        35                  40                  45              


Gln Ser Leu Ala Gln Thr Trp Gln Asp Cys Ala Arg Ala Leu Arg Asp 
    50                  55                  60                  


Leu Gly Ala Lys Leu Pro Gly Leu Ala Gln Arg Thr Ala Ala Ile Ala 
65                  70                  75                  80  


Val Thr Gly Gln Gly Asp Gly Thr Trp Leu Val Gly Lys Asp Asn Arg 
                85                  90                  95      


Pro Val Gly Asp Ala Trp Ile Trp Leu Asp Ala Arg Ala Ala Ser Thr 
            100                 105                 110         


Val Thr Arg Leu Ala Ala Gly Pro Met Asn Arg Ala Arg Phe Glu Ala 
        115                 120                 125             


Thr Gly Thr Gly Leu Asn Thr Cys Gln Gln Gly Ala Gln Met Ala His 
    130                 135                 140                 


Met Asp Thr Ile Ala Pro Glu Leu Leu Asp Asn Ala Glu Ala Ala Leu 
145                 150                 155                 160 


His Cys Lys Asp Trp Leu Tyr Leu Asn Leu Thr Gly Val Arg Ala Thr 
                165                 170                 175     


Asp Pro Ser Glu Ala Ser Phe Thr Phe Gly Asn Phe Arg Thr Arg Gln 
            180                 185                 190         


Tyr Asp Asp Val Val Ile Glu Ala Leu Gly Leu Gln Lys Arg Arg Asn 
        195                 200                 205             


Leu Leu Pro Glu Ile Ile Asp Gly Ser Gln Ser Gln His Pro Leu Ser 
    210                 215                 220                 


Ala Glu Ala Ala Ala Ala Thr Gly Leu Leu Ala Gly Thr Pro Val Ser 
225                 230                 235                 240 


Leu Gly Tyr Val Asp Met Ala Met Thr Ala Leu Gly Ala Gly Val Cys 
                245                 250                 255     


Gly Gly Thr Ala Gly Ala Gly Cys Ser Thr Ile Gly Ser Thr Gly Val 
            260                 265                 270         


His Met Arg Ala Lys Pro Val Ala Asp Ile His Leu Asn Lys Glu Gly 
        275                 280                 285             


Thr Gly Tyr Val Ile Ala Leu Pro Ile Pro Gly Ile Val Thr Gln Val 
    290                 295                 300                 


Gln Thr Asn Met Gly Ala Thr Ile Asn Ile Asp Trp Ile Leu Gln Val 
305                 310                 315                 320 


Ala Ala Asp Leu Met Ser Thr Pro Glu Lys Pro Val Ser Leu Gly Asp 
                325                 330                 335     


Leu Ile Pro Arg Leu Asp Asp Trp Phe Asn Ala Ser Arg Pro Gly Ala 
            340                 345                 350         


Ile Leu Tyr His Pro Tyr Ile Ser Glu Ala Gly Glu Arg Gly Pro Phe 
        355                 360                 365             


Val Asn Ala Asn Ala Arg Ala Gly Phe Ile Gly Leu Ser Ser Arg Asp 
    370                 375                 380                 


Arg Phe Pro Glu Leu Val Arg Ser Val Val Glu Gly Leu Gly Met Ala 
385                 390                 395                 400 


Thr Arg Asp Cys Tyr Ala Ala Met Gly Glu Met Pro Ala Glu Leu Arg 
                405                 410                 415     


Ile Thr Gly Gly Ala Ala Arg Ser Lys Ala Leu Arg Gly Thr Leu Ser 
            420                 425                 430         


Ala Ala Val Asn Ala Pro Val Arg Val Ser Ala Arg Glu Glu Ala Gly 
        435                 440                 445             


Ala Ala Gly Ala Ala Met Met Ala Ala Val Ala Ile Gly Ala Tyr Pro 
    450                 455                 460                 


Ala Met Asp Asp Cys Ile Ala Glu Trp Val Glu Pro Leu Leu Gly Ala 
465                 470                 475                 480 


Ser Glu Ala Pro Asp Ala Ala Arg Ala His Gln Tyr Glu Glu Leu Phe 
                485                 490                 495     


Val Ala Tyr Arg Glu Ala Arg Leu Ala Leu Ala Pro Val Trp Asp Lys 
            500                 505                 510         


Leu Ala Ser Gly Lys 
        515         


