                         SEQUENCE LISTING

<110>  Medigene Immunotherapies GmbH
       Helmholtz Zentrum Mnchen Deutsches Forschungszentrum fr Gesundheit und Umwelt (GmbH)
 
<120>  Novel generation of antigen-specific TCRs

<130>  M10977

<150>  EP15202329
<151>  2015-12-23

<150>  EP16190399
<151>  2016-09-23

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  1
tgtgctgagc ggactcaggg cggatctgaa aagctggtct tt                          42


<210>  2
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  2
tgtgccaccc agagaaacac tgaagctttc ttt                                    33


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Ala Glu Arg Thr Gln Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10                  


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Ala Thr Gln Arg Asn Thr Glu Ala Phe Phe 
1               5                   10      


<210>  5
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  5
atgatgaagt gtccacaggc tttactagct atcttttggc ttctactgag ctgggtgagc       60

agtgaagaca aggtggtaca aagccctcta tctctggttg tccacgaggg agacaccgta      120

actctcaatt gcagttatga agtgactaac tttcgaagcc tactatggta caagcaggaa      180

aagaaagctc ccacatttct atttatgcta acttcaagtg gaattgaaaa gaagtcagga      240

agactaagta gcatattaga taagaaagaa ctttccagca tcctgaacat cacagccacc      300

cagaccggag actcggccat ctacctctgt gctgagcgga ctcagggcgg atctgaaaag      360

ctggtctttg gaaagggaac gaaactgaca gtaaacccat atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                      825


<210>  6
<211>  927
<212>  DNA
<213>  Homo sapiens

<400>  6
atgggcacaa ggttgttctt ctatgtggcc ctttgtctcc tgtggacagg acacatggat       60

gctggaatca cccagagccc aagacacaag gtcacagaga caggaacacc agtgactctg      120

agatgtcacc agactgagaa ccaccgctat atgtactggt atcgacaaga cccggggcat      180

gggctgaggc tgatccatta ctcatatggt gttaaagata ctgacaaagg agaagtctca      240

gatggctata gtgtctctag atcaaagaca gaggatttcc tcctcactct ggagtccgct      300

accagctccc agacatctgt gtacttctgt gccacccaga gaaacactga agctttcttt      360

ggacaaggca ccagactcac agttgtagag gacctgaaaa acgtgttccc acccgaggtc      420

gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc      480

ctggccacag gcttctaccc cgaccacgtg gagctgagct ggtgggtgaa tgggaaggag      540

gtgcacagtg gggtcagcac agacccgcag cccctcaagg agcagcccgc cctcaatgac      600

tccagatact gcctgagcag ccgcctgagg gtctcggcca ccttctggca gaacccccgc      660

aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag      720

gatagggcca aacctgtcac ccagatcgtc agcgccgagg cctggggtag agcagactgt      780

ggcttcacct ccgagtctta ccagcaaggg gtcctgtctg ccaccatcct ctatgagatc      840

ttgctaggga aggccacctt gtatgccgtg ctggtcagtg ccctcgtgct gatggccatg      900

gtcaagagaa aggattccag aggctga                                          927


<210>  7
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Met Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Ser Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Ile Tyr Leu Cys Ala Glu 
            100                 105                 110         


Arg Thr Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Asn Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  8
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gly Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Thr 
1               5                   10                  15      


Gly His Met Asp Ala Gly Ile Thr Gln Ser Pro Arg His Lys Val Thr 
            20                  25                  30          


Glu Thr Gly Thr Pro Val Thr Leu Arg Cys His Gln Thr Glu Asn His 
        35                  40                  45              


Arg Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Lys Asp Thr Asp Lys Gly Glu Val Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ser Lys Thr Glu Asp Phe Leu Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Ser Ser Gln Thr Ser Val Tyr Phe Cys Ala Thr 
            100                 105                 110         


Gln Arg Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu 
    130                 135                 140                 


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu 
            180                 185                 190         


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
225                 230                 235                 240 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asp Ser Arg Gly 
305             


<210>  9
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  9
tgtgctctgc gtcaaacctc ctacgacaag gtgatattt                              39


<210>  10
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  10
tgtgccagca gcttagcgga cagggggagt gaaaaactgt ttttt                       45


<210>  11
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Ala Leu Arg Gln Thr Ser Tyr Asp Lys Val Ile Phe 
1               5                   10              


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Ala Ser Ser Leu Ala Asp Arg Gly Ser Glu Lys Leu Phe Phe 
1               5                   10                  15  


<210>  13
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaactatt ctccaggctt agtatctctg atactcttac tgcttggaag aacccgtgga       60

aattcagtga cccagatgga agggccagtg actctctcag aagaggcctt cctgactata      120

aactgcacgt acacagccac aggataccct tcccttttct ggtatgtcca atatcctgga      180

gaaggtctac agctcctcct gaaagccacg aaggctgatg acaagggaag caacaaaggt      240

tttgaagcca cataccgtaa agaaaccact tctttccact tggagaaagg ctcagttcaa      300

gtgtcagact cagcggtgta cttctgtgct ctgcgtcaaa cctcctacga caaggtgata      360

tttgggccag ggacaagctt atcagtcatt ccaaatatcc agaaccctga ccctgccgtg      420

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat      480

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg      540

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct      600

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc      660

agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac      720

ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg      780

tttaatctgc tcatgacgct gcggctgtgg tccagctga                             819


<210>  14
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  14
atgggcacca ggctcctctg ctgggcggcc ctctgtctcc tgggagcaga actcacagaa       60

gctggagttg cccagtctcc cagatataag attatagaga aaaggcagag tgtggctttt      120

tggtgcaatc ctatatctgg ccatgctacc ctttactggt accagcagat cctgggacag      180

ggcccaaagc ttctgattca gtttcagaat aacggtgtag tggatgattc acagttgcct      240

aaggatcgat tttctgcaga gaggctcaaa ggagtagact ccactctcaa gatccagcct      300

gcaaagcttg aggactcggc cgtgtatctc tgtgccagca gcttagcgga cagggggagt      360

gaaaaactgt tttttggcag tggaacccag ctctctgtct tggaggacct gaacaaggtg      420

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag      480

gccacactgg tgtgcctggc cacaggcttc ttccccgacc acgtggagct gagctggtgg      540

gtgaatggga aggaggtgca cagtggggtc agcacggacc cgcagcccct caaggagcag      600

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc      660

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat      720

gacgagtgga cccaggatag ggccaaaccc gtcacccaga tcgtcagcgc cgaggcctgg      780

ggtagagcag actgtggctt tacctcggtg tcctaccagc aaggggtcct gtctgccacc      840

atcctctatg agatcctgct agggaaggcc accctgtatg ctgtgctggt cagcgccctt      900

gtgttgatgg ccatggtcaa gagaaaggat ttctga                                936


<210>  15
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Arg 
            100                 105                 110         


Gln Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro Gly Thr Ser Leu Ser 
        115                 120                 125             


Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  16
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Ala Asp Arg Gly Ser Glu Lys Leu Phe Phe Gly Ser Gly 
        115                 120                 125             


Thr Gln Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Phe 
305                 310     


<210>  17
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  17
tgtgctgtga gagataattc aggaaacaca cctcttgtct tt                          42


<210>  18
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  18
tgtgccagta gtataatcca gggcagtgct ggctacacct tc                          42


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Ala Val Arg Asp Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Ala Ser Ser Ile Ile Gln Gly Ser Ala Gly Tyr Thr Phe 
1               5                   10                  


<210>  21
<211>  810
<212>  DNA
<213>  Homo sapiens

<400>  21
atgtggggag ttttccttct ttatgtttcc atgaagatgg gaggcactac aggacaaaac       60

attgaccagc ccactgagat gacagctacg gaaggtgcca ttgtccagat caactgcacg      120

taccagacat ctgggttcaa cgggctgttc tggtaccagc aacatgctgg cgaagcaccc      180

acatttctgt cttacaatgt tctggatggt ttggaggaga aaggtcgttt ttcttcattc      240

cttagtcggt ctaaagggta cagttacctc cttttgaagg agctccagat gaaagactct      300

gcctcttacc tctgtgctgt gagagataat tcaggaaaca cacctcttgt ctttggaaag      360

ggcacaagac tttctgtgat tgcaaatatc cagaaccctg accctgccgt gtaccagctg      420

agagactcta aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca      480

aatgtgtcac aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg      540

aggtctatgg acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca      600

tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccagaa      660

agttcctgtg atgtcaagct ggtcgagaaa agctttgaaa cagatacgaa cctaaacttt      720

caaaacctgt cagtgattgg gttccgaatc ctcctcctga aagtggccgg gtttaatctg      780

ctcatgacgc tgcggctgtg gtccagctga                                       810


<210>  22
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  22
atgagcaacc aggtgctctg ctgtgtggtc ctttgtttcc tgggagcaaa caccgtggat       60

ggtggaatca ctcagtcccc aaagtacctg ttcagaaagg aaggacagaa tgtgaccctg      120

agttgtgaac agaatttgaa ccacgatgcc atgtactggt accgacagga cccagggcaa      180

gggctgagat tgatctacta ctcacagata gtaaatgact ttcagaaagg agatatagct      240

gaagggtaca gcgtctctcg ggagaagaag gaatcctttc ctctcactgt gacatcggcc      300

caaaagaacc cgacagcttt ctatctctgt gccagtagta taatccaggg cagtgctggc      360

tacaccttcg gttcggggac caggttaacc gttgtagagg acctgaacaa ggtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttcttcccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtcagcacg gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acccgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gctttacctc ggtgtcctac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatcc tgctagggaa ggccaccctg tatgctgtgc tggtcagcgc ccttgtgttg      900

atggccatgg tcaagagaaa ggatttctga                                       930


<210>  23
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Arg Asp Asn Ser Gly 
            100                 105                 110         


Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser Val Ile Ala 
        115                 120                 125             


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
    130                 135                 140                 


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
145                 150                 155                 160 


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr 
                165                 170                 175     


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
            180                 185                 190         


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
        195                 200                 205             


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
    210                 215                 220                 


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  24
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ser Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Ile Gln Gly Ser Ala Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  25
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  25
tgtgctgccc tccgtggagg tagcaactat aaactgacat tt                          42


<210>  26
<211>  42
<212>  DNA
<213>  Homo sapiens

<400>  26
tgcgccagca gcttggccag gggagtcaat gagcagttct tc                          42


<210>  27
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  27

Cys Ala Ala Leu Arg Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  28

Cys Ala Ser Ser Leu Ala Arg Gly Val Asn Glu Gln Phe Phe 
1               5                   10                  


<210>  29
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  29
atgctcctgc tgctcgtccc agtgctcgag gtgattttta ccctgggagg aaccagagcc       60

cagtcggtga cccagcttgg cagccacgtc tctgtctctg aaggagccct ggttctgctg      120

aggtgcaact actcatcgtc tgttccacca tatctcttct ggtatgtgca ataccccaac      180

caaggactcc agcttctcct gaagtacaca tcagcggcca ccctggttaa aggcatcaac      240

ggttttgagg ctgaatttaa gaagagtgaa acctccttcc acctgacgaa accctcagcc      300

catatgagcg acgcggctga gtacttctgt gctgccctcc gtggaggtag caactataaa      360

ctgacatttg gaaaaggaac tctcttaacc gtgaatccaa atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

actgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gctga                      825


<210>  30
<211>  936
<212>  DNA
<213>  Homo sapiens

<400>  30
atgggctcca ggctgctctg ttgggtgctg ctttgtctcc tgggagcagg cccagtaaag       60

gctggagtca ctcaaactcc aagatatctg atcaaaacga gaggacagca agtgacactg      120

agctgctccc ctatctctgg gcataggagt gtatcctggt accaacagac cccaggacag      180

ggccttcagt tcctctttga atacttcagt gagacacaga gaaacaaagg aaacttccct      240

ggtcgattct cagggcgcca gttctctaac tctcgctctg agatgaatgt gagcaccttg      300

gagctggggg actcggccct ttatctttgc gccagcagct tggccagggg agtcaatgag      360

cagttcttcg ggccagggac acggctcacc gtgctagagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtcagcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tctcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggctga                                936


<210>  31
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Leu Leu Leu Leu Val Pro Val Leu Glu Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Gly Ser His Val Ser Val 
            20                  25                  30          


Ser Glu Gly Ala Leu Val Leu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Pro Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Thr Ser Ala Ala Thr Leu Val Lys Gly Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Lys Lys Ser Glu Thr Ser Phe His Leu Thr 
                85                  90                  95      


Lys Pro Ser Ala His Met Ser Asp Ala Ala Glu Tyr Phe Cys Ala Ala 
            100                 105                 110         


Leu Arg Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu 
        115                 120                 125             


Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  32
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Ser Arg Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Lys Ala Gly Val Thr Gln Thr Pro Arg Tyr Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Ser Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Arg Ser Val Ser Trp Tyr Gln Gln Thr Pro Gly Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Phe Glu Tyr Phe Ser Glu Thr Gln Arg Asn Lys Gly Asn Phe Pro 
65                  70                  75                  80  


Gly Arg Phe Ser Gly Arg Gln Phe Ser Asn Ser Arg Ser Glu Met Asn 
                85                  90                  95      


Val Ser Thr Leu Glu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Ala Arg Gly Val Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  33
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala 
            20                  25              


<210>  34
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Ala Pro Gly Ser Ala Arg Arg Pro Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Met His Cys Ala Ser Ala Ala 
            20                  25                  


<210>  35
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Ser Asp Tyr Thr Ile Val Leu Pro Val Ile Gly Ala Ile Val Val 
1               5                   10                  15      


Gly Leu Cys Leu Met Gly Met Gly Val Tyr Lys Ile Arg Leu Arg Cys 
            20                  25                  30          


Gln Ser Ser Gly Tyr Gln Arg Ile 
        35                  40  


<210>  36
<211>  14
<212>  PRT
<213>  Epstein-Barr virus

<400>  36

Val Val Arg Met Phe Met Arg Glu Arg Gln Leu Pro Gln Ser 
1               5                   10                  


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Tyr Met Asp Gly Thr Met Ser Gln Val 
1               5                   


<210>  38
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any hydrophobic amino acid

<400>  38

Tyr Xaa Xaa Xaa 
1               


<210>  39
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  39

Tyr Gln Arg Ile 
1               


<210>  40
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala 
            20                  25              


<210>  41
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Val Cys Phe Arg Leu Phe Pro Val Pro Gly Ser Gly Leu Val Leu 
1               5                   10                  15      


Val Cys Leu Val Leu Gly Ala Val Arg Ser Tyr Ala Leu 
            20                  25                  


<210>  42
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala 
            20                  25          


<210>  43
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys 
            20                  25              


<210>  44
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly 
            20      


<210>  45
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Arg Leu Ala Val Leu Phe Ser Gly Ala Leu Leu Gly Leu Leu Ala 
1               5                   10                  15      


Ala Gln Gly Thr Gly Asn 
            20          


<210>  46
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn 
    


<210>  47
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Leu Leu Leu Pro Phe Gln Leu Leu Ala Val Leu Phe Pro Gly Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  48
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  48

Gln Glu Gln Gly His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly Pro 
1               5                   10                  15      


Asp Gly Gln Glu Met Asp Pro 
            20              


<210>  49
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  49

Glu Asp Glu Gly Ala Ser Ala Gly Gln Gly Pro Lys Pro Glu Ala Asp 
1               5                   10                  15      


Ser Gln Glu Gln Gly His Pro Gln Thr Gly Cys Glu Cys Glu Asp Gly 
            20                  25                  30          


Pro Asp Gly Gln Glu Met Asp Pro 
        35                  40  


<210>  50
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  50

Pro Glu Val Trp Ile Leu Ser Pro Leu Leu Arg His Gly 
1               5                   10              


<210>  51
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Ala Thr Arg Val Pro Glu Val Trp Ile Leu Ser Pro Leu Leu Arg 
1               5                   10                  15      


His Gly Gly Pro His Thr Gln Thr Gln Asn His Thr 
            20                  25              


<210>  52
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  52

Gln Glu Gly Glu Asp Glu Gly Ala Ser Ala Gly Gln Gly Pro Lys Pro 
1               5                   10                  15      


Glu Ala Asp Ser Gln Glu Gln Gly His Pro Gln Thr Gly Cys Glu Cys 
            20                  25                  30          


Glu Asp Gly Pro Asp Gly Gln Glu Met Asp Pro Pro Asn Pro 
        35                  40                  45      


<210>  53
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  53

Ser Cys Glu Pro Ala Thr Arg Val Pro Glu Val Trp Ile Leu Ser Pro 
1               5                   10                  15      


Leu Leu Arg His Gly Gly Pro His Thr Gln Thr Gln Asn His Thr Ala 
            20                  25                  30          


Ser Pro 
        


<210>  54
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Pro Ser Ser Asp Tyr Thr Ile Val Leu Pro Val Ile Gly Ala Ile 
1               5                   10                  15      


Val Val Gly Leu Cys Leu Met Gly Met Gly Val Tyr Lys Ile Arg Leu 
            20                  25                  30          


Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
        35                  40          


