                         SEQUENCE LISTING

<110>  CASE WESTERN RESERVE UNIVERSITY
       WEISS, Michael
       POKORSKI, Jon
 
<120>  ENCAPSULATION OF ULTRA-STABLE INSULIN ANALOGUES WITH POLYMER 
       MELTS

<130>  200512-00331

<150>  US 62/387,459
<151>  2015-12-23

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phe or an ortho halogenated Phe

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Glu, Ala, Ile, Leu, Val, Norleucine, amino propionic acid 
       or amino butryic acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(41)
<223>  Xaa is 5 11 of any amino acid with the provison that the Xaa at 
       31 or 32 contains an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (49)..(49)
<223>  Xaa is His, Glu, Lys, Arg, or another non beta branched polar or 
       charged amino acid

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa is Tyr, Glu or another non beta branched polar or charged 
       amino acid

<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa is Asn, Gly, Ala, Asp or Ser

<400>  4

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Ile Val Glu Gln Cys Cys 
        35                  40                  45              


Xaa Ser Cys Cys Ser Leu Xaa Gln Leu Glu Asn Tyr Cys Xaa 
    50                  55                  60          


<210>  5
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phe or an ortho halogenated Phe

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Glu, Ala, Ile, Leu, Val, Norleucine, amino propionic acid 
       or amino butryic acid

<400>  5

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr 
            20                  25                  30  


<210>  6
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is His, Glu, Lys, Arg, or another non beta branched polar or 
       charged amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyr, Glu or another non beta branched polar or charged 
       amino acid

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asn, Gly, Ala, Asp or Ser

<400>  6

Gly Ile Val Glu Gln Cys Cys Xaa Ser Cys Cys Ser Leu Xaa Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  7
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Phe or an ortho halogenated Phe

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Glu, Ala, Ile, Leu, Val, Norleucine, amino propionic acid 
       or amino butryic acid

<400>  7

Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu 
1               5                   10                  15      


Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr 
            20                  25                  


<210>  8
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Phe or an ortho halogenated Phe

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Glu, Ala, Ile, Leu, Val, Norleucine, amino propionic acid 
       or amino butryic acid

<400>  8

Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr Leu Val 
1               5                   10                  15      


Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr 
            20                  25              


<210>  9
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  9

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Glu Glu 
            20                  25                  30          


Gly Ser Arg Arg Ser Arg Gly Ile Val Glu Gln Cys Cys Arg Ser Ile 
        35                  40                  45              


Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  


<210>  10
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Arg Thr Glu Glu 
            20                  25                  30          


Gly Ser Arg Arg Ser Arg Gly Ile Val Glu Gln Cys Cys Arg Ser Cys 
        35                  40                  45              


Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55                  


<210>  11
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  11

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
            20                  25                  30          


Gly Pro Arg Arg Gly Ile Val Glu Gln Cys Cys Glu Ser Cys Cys Ser 
        35                  40                  45              


Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  12
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
            20                  25                  30          


Gly Pro Arg Arg Gly Ile Val Glu Gln Cys Cys His Ser Cys Cys Ser 
        35                  40                  45              


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  13
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  13

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  15
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Val Asn Cys His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Pro Thr Glu Glu 
            20                  25                  30          


Gly Pro Arg Arg Gly Ile Val Glu Gln Cys Cys His Ser Cys Cys Ser 
        35                  40                  45              


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


<210>  16
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Pro Thr Glu Glu 
            20                  25                  30          


Gly Pro Arg Arg Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser 
        35                  40                  45              


Leu Glu Gln Leu Glu Asn Tyr Cys Asn 
    50                  55          


