                         SEQUENCE LISTING

<110>  Progastrine et Cancers S. r.l.
 
<120>  Compositions and methods for detecting and treating esophageal 
       cancer

<130>  B371680D34986

<150>  EP 16305139.4
<151>  2016-02-05

<150>  EP 15307189.9
<151>  2015-12-31

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  80
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(80)
<223>  Human progastrin

<400>  1

Ser Trp Lys Pro Arg Ser Gln Gln Pro Asp Ala Pro Leu Gly Thr Gly 
1               5                   10                  15      


Ala Asn Arg Asp Leu Glu Leu Pro Trp Leu Glu Gln Gln Gly Pro Ala 
            20                  25                  30          


Ser His His Arg Arg Gln Leu Gly Pro Gln Gly Pro Pro His Leu Val 
        35                  40                  45              


Ala Asp Pro Ser Lys Lys Gln Gly Pro Trp Leu Glu Glu Glu Glu Glu 
    50                  55                  60                  


Ala Tyr Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Asp Glu Asn 
65                  70                  75                  80  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids 1-14, N-terminal extremity of human progastrin

<400>  2

Ser Trp Lys Pro Arg Ser Gln Gln Pro Asp Ala Pro Leu Gly 
1               5                   10                  


<210>  3
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids 55-80, C-terminal extremity of human progastrin

<400>  3

Gln Gly Pro Trp Leu Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp 
1               5                   10                  15      


Phe Gly Arg Arg Ser Ala Glu Asp Glu Asn 
            20                  25      


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  6B5B11C10 CDR-H1

<400>  4

Gly Tyr Ile Phe Thr Ser Tyr Trp 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  6B5B11C10 CDR-H2

<400>  5

Phe Tyr Pro Gly Asn Ser Asp Ser 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  6B5B11C10 CDR-H3

<400>  6

Thr Arg Arg Asp Ser Pro Gln Tyr 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  6B5B11C10 CDR-L1

<400>  7

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  8
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  6B5B11C10 CDR-L2

<400>  8

Lys Val Ser 
1           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  6B5B11C10 CDR-L3

<400>  9

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  10
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  20D2C3G2 CDR-H1

<400>  10

Gly Tyr Thr Phe Ser Ser Trp 
1               5           


<210>  11
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  20D2C3G2 CDR-H2

<400>  11

Phe Leu Pro Gly Ser Gly Ser Thr 
1               5               


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  20D2C3G2 CDR-H3

<400>  12

Ala Thr Asp Gly Asn Tyr Asp Trp Phe Ala Tyr 
1               5                   10      


<210>  13
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  20D2C3G2 CDR-L1

<400>  13

Gln Ser Leu Val His Ser Ser Gly Val Thr Tyr 
1               5                   10      


<210>  14
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  20D2C3G2 CDR-L2

<400>  14

Lys Val Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  20D2C3G2 CDR-L3

<400>  15

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  1E9D9B6 CDR-H1

<400>  16

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  1E9D9B6 CDR-H2

<400>  17

Ile Asn Pro Ser Asn Gly Gly Thr 
1               5               


<210>  18
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  1E9D9B6 CDR-H3

<400>  18

Thr Arg Gly Gly Tyr Tyr Pro Phe Asp Tyr 
1               5                   10  


<210>  19
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  1E9D9B6 CDR-L1

<400>  19

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  20
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  1E9D9B6 CDR-L2

<400>  20

Leu Val Ser 
1           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  1E9D9B6 CDR-L3

<400>  21

Trp Gln Gly Thr His Ser Pro Tyr Thr 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  1B3B4F11 CDR-H1

<400>  22

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  1B3B4F11 CDR-H2

<400>  23

Ile Ser Phe Ser Gly Tyr Thr 
1               5           


<210>  24
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  1B3B4F11 CDR-H3

<400>  24

Ala Arg Glu Val Asn Tyr Gly Asp Ser Tyr His Phe Asp Tyr 
1               5                   10                  


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  1B3B4F11 CDR-L1

<400>  25

Ser Gln His Arg Thr Tyr Thr 
1               5           


<210>  26
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  1B3B4F11 CDR-L2

<400>  26

Val Lys Lys Asp Gly Ser His 
1               5           


<210>  27
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  1B3B4F11 CDR-L3

<400>  27

Gly Val Gly Asp Ala Ile Lys Gly Gln Ser Val Phe Val 
1               5                   10              


<210>  28
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  1C10D3B9 CDR-H1

<400>  28

Gly Phe Thr Phe Thr Thr Tyr Ala 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  1C10D3B9 CDR-H2

<400>  29

Ile Ser Ser Gly Gly Thr Tyr Thr 
1               5               


<210>  30
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  1C10D3B9 CDR-H3

<400>  30

Ala Thr Gln Gly Asn Tyr Ser Leu Asp Phe 
1               5                   10  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  1C10D3B9 CDR-L1

<400>  31

Lys Ser Leu Arg His Thr Lys Gly Ile Thr Phe 
1               5                   10      


<210>  32
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  1C10D3B9 CDR-L2

<400>  32

Gln Met Ser 
1           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  1C10D3B9 CDR-L3

<400>  33

Ala Gln Asn Leu Glu Leu Pro Leu Thr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  2C6C3C7 CDR-H1

<400>  34

Gly Phe Ile Phe Ser Ser Tyr Gly 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  2C6C3C7 CDR-H2

<400>  35

Ile Asn Thr Phe Gly Asp Arg Thr 
1               5               


<210>  36
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  2C6C3C7 CDR-H3

<400>  36

Ala Arg Gly Thr Gly Thr Tyr 
1               5           


<210>  37
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  2C6C3C7 CDR-L1

<400>  37

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  38
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  2C6C3C7 CDR-L2

<400>  38

Leu Val Ser 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  2C6C3C7 CDR-L3

<400>  39

Trp Gln Gly Thr His Phe Pro Gln Thr 
1               5                   


<210>  40
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids 71-80 of progastrin

<400>  40

Phe Gly Arg Arg Ser Ala Glu Asp Glu Asn 
1               5                   10  


