                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Taunton, John W.
       Lim, Wendell A.
       Wu, Chia-Yung
 
<120>  CONDITIONALLY ACTIVE HETERODIMERIC POLYPEPTIDES AND METHODS OF 
       USE THEREOF

<130>  UCSF-524WO

<150>  US62/276,725
<151>  2016-01-08

<160>  723   

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  1

Cys Pro Ser Ser His Ser Ser Leu Thr Glu Arg His Lys Ile Leu His 
1               5                   10                  15      


Arg Leu Leu Gln Glu Gly Ser Pro Ser 
            20                  25  


<210>  2
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  2

Ser Leu Thr Ala Arg His Lys Ile Leu His Arg Leu Leu Gln Glu Gly 
1               5                   10                  15      


Ser Pro Ser Asp Ile 
            20      


<210>  3
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  3

Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser Ser 
1               5                   10                  15      


Asp Asp Arg 
            


<210>  4
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  4

Pro Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp 
1               5                   10                  15      


Asp Pro Ser Asp Val 
            20      


<210>  5
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  5

Ala Glu Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn 
1               5                   10                  15      


Thr 
    


<210>  6
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  6

Gln Glu Ala Glu Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro 
1               5                   10                  15      


Ala Asn Thr Gln Leu 
            20      


<210>  7
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  7

Ser Lys Val Ser Gln Asn Pro Ile Leu Thr Ser Leu Leu Gln Ile Thr 
1               5                   10                  15      


Gly Asn Gly Gly Ser 
            20      


<210>  8
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  8

Gly His Ser Phe Ala Asp Pro Ala Ser Asn Leu Gly Leu Glu Asp Ile 
1               5                   10                  15      


Ile Arg Lys Ala Leu Met Gly Ser Phe 
            20                  25  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  9

Pro Arg Gln Gly Ser Ile Leu Tyr Ser Met Leu Thr Ser Ala Lys Gln 
1               5                   10                  15      


Thr 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  10

Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu Lys Ser Gln Thr Ile 
1               5                   10                  15      


Pro 
    


<210>  11
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  11

Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
1               5                   10                  15      


Asp Thr Lys Asp Ile 
            20      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  12

Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp 
1               5                   10                  15      


<210>  13
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  13

Ser Pro Gly Ser Arg Glu Trp Phe Lys Asp Met Leu Ser 
1               5                   10              


<210>  14
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  14

Gly Asn Thr Lys Asn His Pro Met Leu Met Asn Leu Leu Lys Asp Asn 
1               5                   10                  15      


Pro Ala Gln Asp Phe 
            20      


<210>  15
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  15

Ser Ser Lys Gly Val Leu Trp Arg Met Leu Ala Glu Pro Val Ser Arg 
1               5                   10                  15      


<210>  16
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  16

Ser Arg Thr Leu Gln Leu Asp Trp Gly Thr Leu Tyr Trp Ser Arg 
1               5                   10                  15  


<210>  17
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  17

Ser Ser Asn His Gln Ser Ser Arg Leu Ile Glu Leu Leu Ser Arg 
1               5                   10                  15  


<210>  18
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  18

Leu Lys Glu Lys His Lys Ile Leu His Arg Leu Leu Gln Asp Ser Ser 
1               5                   10                  15      


Ser Pro Val 
            


<210>  19
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  19

Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
1               5                   10                  


<210>  20
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  20

Lys Tyr Ser Gln Thr Ser His Lys Leu Val Gln Leu Leu Thr Thr Thr 
1               5                   10                  15      


Ala Glu Gln Gln Leu 
            20      


<210>  21
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  21

Ser Leu Thr Ala Arg His Lys Ile Leu His Arg Leu Leu Gln Glu Gly 
1               5                   10                  15      


Ser Pro Ser Asp Ile 
            20      


<210>  22
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  22

Lys Glu Ser Lys Asp His Gln Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
1               5                   10                  15      


Glu Lys Asp Leu Arg 
            20      


<210>  23
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  23

Pro Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  24

Pro Gln Ala Gln Gln Lys Ser Leu Arg Gln Gln Leu Leu Thr Glu 
1               5                   10                  15  


<210>  25
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  25

His Asp Ser Lys Gly Gln Thr Lys Leu Leu Gln Leu Leu Thr Thr Lys 
1               5                   10                  15      


Ser Asp Gln Met Glu 
            20      


<210>  26
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  26

Ser Leu Lys Glu Lys His Lys Ile Leu His Arg Leu Leu Gln Asp Ser 
1               5                   10                  15      


Ser Ser Pro Val Asp 
            20      


<210>  27
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  27

Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
1               5                   10                  15      


Asp Thr Lys Asp Ile 
            20      


<210>  28
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  28

Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu Leu Thr Cys Ser 
1               5                   10                  15      


Ser Asp Asp Arg Gly 
            20      


<210>  29
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  29

Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly 
1               5                   10                  15      


Asn Ser Pro Ala Glu 
            20      


<210>  30
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  30

Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp 
1               5                   10                  15      


Asp Pro Ser Asp Ala 
            20      


<210>  31
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  31

Gln Glu Ala Glu Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro 
1               5                   10                  15      


Ala Asn Thr Gln Leu 
            20      


<210>  32
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  32

Pro Glu Val Asp Glu Leu Ser Leu Leu Gln Lys Leu Leu Leu Ala Thr 
1               5                   10                  15      


Ser Tyr Pro Thr Ser 
            20      


<210>  33
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  33

Val Ser Pro Arg Glu Gly Ser Ser Leu His Lys Leu Leu Thr Leu Ser 
1               5                   10                  15      


Arg Thr Pro Pro Glu 
            20      


<210>  34
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  34

Ser Lys Val Ser Gln Asn Pro Ile Leu Thr Ser Leu Leu Gln Ile Thr 
1               5                   10                  15      


Gly Asn Gly Gly Ser 
            20      


<210>  35
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  35

Gly Asn Thr Lys Asn His Pro Met Leu Met Asn Leu Leu Lys Asp Asn 
1               5                   10                  15      


Pro Ala Gln Asp Phe 
            20      


<210>  36
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  36

Asp Val Thr Leu Thr Ser Pro Leu Leu Val Asn Leu Leu Gln Ser Asp 
1               5                   10                  15      


Ile Ser Ala Gly His 
            20      


<210>  37
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  37

Ala Met Arg Glu Ala Pro Thr Ser Leu Ser Gln Leu Leu Asp Asn Ser 
1               5                   10                  15      


Gly Ala Pro Asn Val 
            20      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  38

Asp Ala Ala Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly 
1               5                   10                  15      


Ser Gly Ser Ser Ile 
            20      


<210>  39
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  39

Lys Arg Lys Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His 
1               5                   10                  15      


Lys Cys Gln Arg Arg 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  40

Asp Ala Ala Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Ser Gly 
1               5                   10                  15      


Ser Ser Pro Asn Leu 
            20      


<210>  41
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  41

Gly His Pro Pro Ala Ile Gln Ser Leu Ile Asn Leu Leu Ala Asp Asn 
1               5                   10                  15      


Arg Tyr Leu Thr Ala 
            20      


<210>  42
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  42

Thr Leu Gln Gln Gln Ala Gln Gln Leu Tyr Ser Leu Leu Gly Gln Phe 
1               5                   10                  15      


Asn Cys Leu Thr His 
            20      


<210>  43
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  43

Gly Ser Arg Glu Thr Ser Glu Lys Phe Lys Leu Leu Phe Gln Ser Tyr 
1               5                   10                  15      


Asn Val Asn Asp Trp 
            20      


<210>  44
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  44

Asn Ala Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser 
1               5                   10                  15      


Ser Gln Ser Ser Thr 
            20      


<210>  45
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  45

Ile Pro Ile Glu Pro Asp Tyr Lys Phe Ser Thr Leu Leu Met Met Leu 
1               5                   10                  15      


Lys Asp Met His Asp 
            20      


<210>  46
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  46

Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser Glu Leu Leu Lys Lys Gly 
1               5                   10                  15      


Ser Leu Leu Pro Thr 
            20      


<210>  47
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  47

Val Asp Gly His Glu Arg Ala Met Leu Lys Arg Leu Leu Arg Ile Asp 
1               5                   10                  15      


Ser Lys Cys Leu His 
            20      


<210>  48
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  48

His Glu Asp Leu Asp Lys Val Lys Leu Ile Glu Tyr Tyr Leu Thr Lys 
1               5                   10                  15      


Asn Lys Glu Gly Pro 
            20      


<210>  49
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  49

Glu Ser Pro Glu Phe Cys Leu Gly Leu Gln Thr Leu Leu Ser Leu Lys 
1               5                   10                  15      


Cys Cys Ile Asp Leu 
            20      


<210>  50
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  50

Ala Ala Thr Thr Gln Asn Pro Val Leu Ser Lys Leu Leu Met Ala Asp 
1               5                   10                  15      


Gln Asp Ser Pro Leu 
            20      


<210>  51
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  51

Met Gly Gln Val Pro Arg Thr His Arg Leu Ile Thr Leu Ala Asp His 
1               5                   10                  15      


Ile Cys Gln Ile Ile Thr Gln Asp Phe Ala Arg Asn Gln Val 
            20                  25                  30  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  52

Asn Leu Gly Leu Glu Asp Ile Ile Arg Lys Ala Leu Met Gly 
1               5                   10                  


<210>  53
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  53

Ala Pro Gly Val Lys Gly His Gln Arg Val Val Thr Leu Ala Gln His 
1               5                   10                  15      


Ile Ser Glu Val Ile Thr Gln Asp Thr Tyr Arg His His Pro Gln Gln 
            20                  25                  30          


Leu Ser Ala Pro Leu Pro Ala Pro 
        35                  40  


<210>  54
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  54

Asn Met Gly Leu Glu Ala Ile Ile Arg Lys Ala Leu Met Gly 
1               5                   10                  


<210>  55
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  55

Arg Leu Thr Lys Thr Asn Pro Ile Leu Tyr Tyr Met Leu Gln Lys Gly 
1               5                   10                  15      


Gly Asn Ser Val Ala 
            20      


<210>  56
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  56

Gln Asp Ser Ile Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln 
1               5                   10                  15      


Ala Ala Gly Gly Ser 
            20      


<210>  57
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  57

Lys Gly Lys Gln Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe 
1               5                   10                  15      


Ser Ser Arg Leu Gln 
            20      


<210>  58
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  58

Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
1               5                   10                  15      


Lys Val Lys Asp Gln 
            20      


<210>  59
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  59

Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser Glu 
1               5                   10                  15      


Ala His Leu Gln Gln 
            20      


<210>  60
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  60

Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu Lys Ser Gln 
1               5                   10                  15      


Thr Ile Pro Lys Pro 
            20      


<210>  61
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  61

Asn Ser His Gln Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys 
1               5                   10                  15      


Asn Glu Glu Asn Val 
            20      


<210>  62
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  62

Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
1               5                   10                  15      


Thr Lys Gly Arg Val 
            20      


<210>  63
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  63

Phe Ser Phe Ser Lys Asn Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn 
1               5                   10                  15      


Gln Asp Ser Tyr Leu 
            20      


<210>  64
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  64

Arg Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu 
1               5                   10                  15      


Asn Cys Val Arg Asp 
            20      


<210>  65
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  65

Glu Leu Asn Ala Asp Asp Ala Ile Leu Arg Glu Leu Leu Asp Glu Ser 
1               5                   10                  15      


Gln Lys Val Met Val 
            20      


<210>  66
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  66

Tyr Glu Asn Leu Pro Pro Ala Ala Leu Arg Lys Leu Leu Arg Ala Glu 
1               5                   10                  15      


Pro Glu Arg Tyr Arg 
            20      


<210>  67
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  67

Met Ala Phe Ala Gly Asp Glu Val Leu Val Gln Leu Leu Ser Gly Asp 
1               5                   10                  15      


Lys Ala Pro Glu Gly 
            20      


<210>  68
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  68

Ser Cys Cys Tyr Leu Cys Ile Arg Leu Glu Gly Leu Leu Ala Pro Thr 
1               5                   10                  15      


Ala Ser Pro Arg Pro 
            20      


<210>  69
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  69

Pro Ser Asn Lys Ser Val Asp Val Leu Ala Gly Leu Leu Leu Arg Arg 
1               5                   10                  15      


Met Glu Leu Lys Pro 
            20      


<210>  70
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Glu Thr Lys Gly Tyr His Ser Leu Pro Glu Gly Leu Asp Met Glu 
1               5                   10                  15      


Arg Arg Trp Gly Gln Val Ser Gln Ala Val Glu Arg Ser Ser Leu Gly 
            20                  25                  30          


Pro Thr Glu Arg Thr Asp Glu Asn Asn Tyr Met Glu Ile Val Asn Val 
        35                  40                  45              


Ser Cys Val Ser Gly Ala Ile Pro Asn Asn Ser Thr Gln Gly Ser Ser 
    50                  55                  60                  


Lys Glu Lys Gln Glu Leu Leu Pro Cys Leu Gln Gln Asp Asn Asn Arg 
65                  70                  75                  80  


Pro Gly Ile Leu Thr Ser Asp Ile Lys Thr Glu Leu Glu Ser Lys Glu 
                85                  90                  95      


Leu Ser Ala Thr Val Ala Glu Ser Met Gly Leu Tyr Met Asp Ser Val 
            100                 105                 110         


Arg Asp Ala Asp Tyr Ser Tyr Glu Gln Gln Asn Gln Gln Gly Ser Met 
        115                 120                 125             


Ser Pro Ala Lys Ile Tyr Gln Asn Val Glu Gln Leu Val Lys Phe Tyr 
    130                 135                 140                 


Lys Gly Asn Gly His Arg Pro Ser Thr Leu Ser Cys Val Asn Thr Pro 
145                 150                 155                 160 


Leu Arg Ser Phe Met Ser Asp Ser Gly Ser Ser Val Asn Gly Gly Val 
                165                 170                 175     


Met Arg Ala Val Val Lys Ser Pro Ile Met Cys His Glu Lys Ser Pro 
            180                 185                 190         


Ser Val Cys Ser Pro Leu Asn Met Thr Ser Ser Val Cys Ser Pro Ala 
        195                 200                 205             


Gly Ile Asn Ser Val Ser Ser Thr Thr Ala Ser Phe Gly Ser Phe Pro 
    210                 215                 220                 


Val His Ser Pro Ile Thr Gln Gly Thr Pro Leu Thr Cys Ser Pro Asn 
225                 230                 235                 240 


Val Glu Asn Arg Gly Ser Arg Ser His Ser Pro Ala His Ala Ser Asn 
                245                 250                 255     


Val Gly Ser Pro Leu Ser Ser Pro Leu Ser Ser Met Lys Ser Ser Ile 
            260                 265                 270         


Ser Ser Pro Pro Ser His Cys Ser Val Lys Ser Pro Val Ser Ser Pro 
        275                 280                 285             


Asn Asn Val Thr Leu Arg Ser Ser Val Ser Ser Pro Ala Asn Ile Asn 
    290                 295                 300                 


Asn Ser Arg Cys Ser Val Ser Ser Pro Ser Asn Thr Asn Asn Arg Ser 
305                 310                 315                 320 


Thr Leu Ser Ser Pro Ala Ala Ser Thr Val Gly Ser Ile Cys Ser Pro 
                325                 330                 335     


Val Asn Asn Ala Phe Ser Tyr Thr Ala Ser Gly Thr Ser Ala Gly Ser 
            340                 345                 350         


Ser Thr Leu Arg Asp Val Val Pro Ser Pro Asp Thr Gln Glu Lys Gly 
        355                 360                 365             


Ala Gln Glu Val Pro Phe Pro Lys Thr Glu Glu Val Glu Ser Ala Ile 
    370                 375                 380                 


Ser Asn Gly Val Thr Gly Gln Leu Asn Ile Val Gln Tyr Ile Lys Pro 
385                 390                 395                 400 


Glu Pro Asp Gly Ala Phe Ser Ser Ser Cys Leu Gly Gly Asn Ser Lys 
                405                 410                 415     


Ile Asn Ser Asp Ser Ser Phe Ser Val Pro Ile Lys Gln Glu Ser Thr 
            420                 425                 430         


Lys His Ser Cys Ser Gly Thr Ser Phe Lys Gly Asn Pro Thr Val Asn 
        435                 440                 445             


Pro Phe Pro Phe Met Asp Gly Ser Tyr Phe Ser Phe Met Asp Asp Lys 
    450                 455                 460                 


Asp Tyr Tyr Ser Leu Ser Gly Ile Leu Gly Pro Pro Val Pro Gly Phe 
465                 470                 475                 480 


Asp Gly Asn Cys Glu Gly Ser Gly Phe Pro Val Gly Ile Lys Gln Glu 
                485                 490                 495     


Pro Asp Asp Gly Ser Tyr Tyr Pro Glu Ala Ser Ile Pro Ser Ser Ala 
            500                 505                 510         


Ile Val Gly Val Asn Ser Gly Gly Gln Ser Phe His Tyr Arg Ile Gly 
        515                 520                 525             


Ala Gln Gly Thr Ile Ser Leu Ser Arg Ser Ala Arg Asp Gln Ser Phe 
    530                 535                 540                 


Gln His Leu Ser Ser Phe Pro Pro Val Asn Thr Leu Val Glu Ser Trp 
545                 550                 555                 560 


Lys Ser His Gly Asp Leu Ser Ser Arg Arg Ser Asp Gly Tyr Pro Val 
                565                 570                 575     


Leu Glu Tyr Ile Pro Glu Asn Val Ser Ser Ser Thr Leu Arg Ser Val 
            580                 585                 590         


Ser Thr Gly Ser Ser Arg Pro Ser Lys Ile Cys Leu Val Cys Gly Asp 
        595                 600                 605             


Glu Ala Ser Gly Cys His Tyr Gly Val Val Thr Cys Gly Ser Cys Lys 
    610                 615                 620                 


Val Phe Phe Lys Arg Ala Val Glu Gly Gln His Asn Tyr Leu Cys Ala 
625                 630                 635                 640 


Gly Arg Asn Asp Cys Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro 
                645                 650                 655     


Ala Cys Arg Leu Gln Lys Cys Leu Gln Ala Gly Met Asn Leu Gly Ala 
            660                 665                 670         


Arg Lys Ser Lys Lys Leu Gly Lys Leu Lys Gly Ile His Glu Glu Gln 
        675                 680                 685             


Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Gln Ser Pro 
    690                 695                 700                 


Glu Glu Gly Thr Thr Tyr Ile Ala Pro Ala Lys Glu Pro Ser Val Asn 
705                 710                 715                 720 


Thr Ala Leu Val Pro Gln Leu Ser Thr Ile Ser Arg Ala Leu Thr Pro 
                725                 730                 735     


Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
            740                 745                 750         


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
        755                 760                 765             


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
    770                 775                 780                 


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
785                 790                 795                 800 


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
                805                 810                 815     


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
            820                 825                 830         


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
        835                 840                 845             


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
    850                 855                 860                 


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
865                 870                 875                 880 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
                885                 890                 895     


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
            900                 905                 910         


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
        915                 920                 925             


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
    930                 935                 940                 


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
945                 950                 955                 960 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
                965                 970                 975     


Lys Pro Leu Tyr Phe His Arg Lys 
            980                 


<210>  71
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  71

Glu Glu Gln Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Gln Ser Pro Glu Glu Gly Thr Thr Tyr Ile Ala Pro Ala Lys Glu Pro 
            20                  25                  30          


Ser Val Asn Thr Ala Leu Val Pro Gln Leu Ser Thr Ile Ser Arg Ala 
        35                  40                  45              


Leu Thr Pro Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile 
    50                  55                  60                  


Val Tyr Ala Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu 
65                  70                  75                  80  


Leu Ser Thr Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val 
                85                  90                  95      


Lys Trp Ala Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp 
            100                 105                 110         


Gln Ile Thr Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala 
        115                 120                 125             


Leu Ser Trp Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe 
    130                 135                 140                 


Ala Pro Asp Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met 
145                 150                 155                 160 


Tyr Glu Leu Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg 
                165                 170                 175     


Leu Gln Leu Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu 
            180                 185                 190         


Leu Ser Thr Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu 
        195                 200                 205             


Glu Met Arg Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys 
    210                 215                 220                 


Cys Pro Asn Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr 
225                 230                 235                 240 


Lys Leu Leu Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe 
                245                 250                 255     


Cys Phe Tyr Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro 
            260                 265                 270         


Ala Met Leu Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser 
        275                 280                 285             


Gly Asn Ala Lys Pro Leu Tyr Phe His Arg Lys 
    290                 295                 


<210>  72
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  73
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  73

Glu Glu Gln Pro Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Gln Ser Pro Glu Glu Gly Thr Thr Tyr Ile Ala Pro Ala Lys Glu Pro 
            20                  25                  30          


Ser Val Asn Thr Ala Leu Val Pro Gln Leu Ser Thr Ile Ser Arg Ala 
        35                  40                  45              


Leu Thr Pro Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile 
    50                  55                  60                  


Val Tyr Ala Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu 
65                  70                  75                  80  


Leu Ser Thr Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val 
                85                  90                  95      


Lys Trp Ala Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp 
            100                 105                 110         


Gln Ile Thr Leu Ile Gln Tyr Ser Trp Met Cys Leu Leu Ser Phe Ala 
        115                 120                 125             


Leu Ser Trp Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe 
    130                 135                 140                 


Ala Pro Asp Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met 
145                 150                 155                 160 


Tyr Glu Leu Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg 
                165                 170                 175     


Leu Gln Leu Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu 
            180                 185                 190         


Leu Ser Thr Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu 
        195                 200                 205             


Glu Met Arg Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys 
    210                 215                 220                 


Cys Pro Asn Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr 
225                 230                 235                 240 


Lys Leu Leu Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe 
                245                 250                 255     


Cys Phe Tyr Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro 
            260                 265                 270         


Ala Met Leu Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser 
        275                 280                 285             


Gly Asn Ala Lys Pro Leu Tyr Phe His Arg Lys 
    290                 295                 


<210>  74
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  74

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Leu Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  75
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  75

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Leu Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  76
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  76

Ser Pro Val Lys Ile Leu Glu Ser Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Tyr Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Ile Leu Pro Gly Phe Arg Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Phe Asp Glu Glu Arg Met Arg Gln Ser Ala Met Phe Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Ser Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Ala Asn Tyr Ile Lys Glu Leu Lys Lys Met Val Thr Lys Cys Pro Ser 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser Gln Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  77
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  77

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Ser Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  78
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  78

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Ser Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Cys Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  79
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  79

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Leu Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Ala Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  80
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Leu Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Ala Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  81
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  81

Ser Pro Val Met Val Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Lys Pro Asp Thr Ala Glu Asn Leu Leu Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Ile Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Lys Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Glu Lys Met His Gln Ser Ala Met Tyr Glu Leu 
            100                 105                 110         


Cys Gln Gly Met His Gln Ile Ser Leu Gln Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Ile Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Asp Gly Leu Lys Ser Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Thr Asn Tyr Ile Lys Glu Leu Arg Lys Met Val Thr Lys Ala Pro Asn 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Ser Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser His Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Asn Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  82
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  82

Ser Ala Ala Val Ile Leu Glu Asn Ile Glu Pro Glu Ile Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Asn Thr Gln Pro Asp Thr Ala Glu Asn Leu Leu Ser Ser 
            20                  25                  30          


Leu Asn Gln Leu Ala Gly Lys Gln Met Val Gln Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Ile Pro Gly Phe Arg Asn Leu Pro Leu Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ala Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Ala Ser Ser Gln Phe Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Phe Asn Glu Glu Arg Met Arg Gln Ser Ala Met Tyr Asp Leu 
            100                 105                 110         


Cys Gln Gly Met Gln Gln Ile Ser Leu Glu Phe Ser Arg Leu Gln Leu 
        115                 120                 125             


Thr Phe Glu Glu Tyr Thr Leu Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Cys Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Val Asn Tyr Ile Lys Glu Leu Arg Lys Val Leu Leu Lys Ser Pro His 
                165                 170                 175     


Asn Ser Gly Gln Ser Trp Gln Arg Tyr Phe Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met Gln Asp Leu Val Gly Asp Leu Leu Glu Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser Gln Ala Leu Lys Val Glu Phe Pro Ala Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Leu Pro Lys Val Glu Ser Gly Ile Ala 
225                 230                 235                 240 


Lys Pro Leu Tyr Phe His Arg Lys 
                245             


<210>  83
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  83

Ser Ile Cys Ser Val Leu Glu Leu Ile Glu Pro Glu Val Val Phe Ala 
1               5                   10                  15      


Gly Tyr Asp Asn Thr Gln Pro Asp Thr Thr Asp His Leu Leu Ser Ser 
            20                  25                  30          


Leu Asn Gln Leu Ala Gly Lys Gln Met Ile Arg Val Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Arg Gly Leu Pro Ile Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Ser Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Phe Asn Glu Asp Arg Met Gln Gln Ser Ala Met Tyr Asp Leu 
            100                 105                 110         


Cys Leu Gly Met Arg Gln Val Ser Gln Glu Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Thr Tyr Gln Glu Phe Leu Ser Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Val Pro Lys Glu Gly Leu Lys Asn Gln Ala Ala Phe Glu Glu Met Arg 
145                 150                 155                 160 


Val Asn Tyr Ile Lys Glu Leu Arg Arg Ser Val Gly Lys Ala Pro Thr 
                165                 170                 175     


Thr Leu Asp Arg Arg Gly Asn Arg Ser Ser Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ala Met His Asp Leu Gly Gly Glu Leu Leu Asp Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Arg Glu Ser Gln Ala Leu Lys Val Glu Phe Pro Glu Met Leu 
    210                 215                 220                 


Val Glu Ile Ile Ser Asp Gln Ile Pro Lys Val Glu Ser Gly Asn Thr 
225                 230                 235                 240 


His Thr Leu Tyr Phe His Lys Lys 
                245             


<210>  84
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Ile Cys Ser Ile Leu Glu Leu Ile Glu Pro Glu Glu Val Tyr Ser 
1               5                   10                  15      


Gly Tyr Asp Asn Thr Gln Pro Asp Thr Thr Asp His Leu Leu Ser Ser 
            20                  25                  30          


Leu Asn Arg Leu Ala Gly Lys Gln Met Val Arg Met Val Lys Trp Ala 
        35                  40                  45              


Lys Val Leu Pro Gly Phe Arg Gly Leu Pro Ile Glu Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Cys Leu Ser Ser Phe Cys Leu Ser Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Thr Asn Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Phe Asn Glu Glu Arg Met Arg Gln Ser Ala Met Tyr Asp Leu 
            100                 105                 110         


Cys Leu Gly Met Arg Gln Val Ser Gln Glu Phe Leu Arg Leu Gln Leu 
        115                 120                 125             


Ser Tyr Asp Glu Phe Leu Ser Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Gly Leu Gly Arg Leu Thr Leu Phe Gly Phe His Cys Ser Lys Gln Leu 
145                 150                 155                 160 


Pro Pro Ser Pro Pro His Met Arg Thr Val Pro Lys Glu Gly Leu Lys 
                165                 170                 175     


Asn Gln Ala Ala Phe Glu Glu Met Arg Leu Asn Tyr Ile Lys Glu Leu 
            180                 185                 190         


Arg Arg Ser Val Gly Lys Ala Thr Asn Asn Ser Gly Gln Thr Trp Gln 
        195                 200                 205             


Arg Phe Phe Gln Leu Thr Lys Leu Leu Asp Ala Met His Asp Val Ser 
    210                 215                 220                 


Thr Leu Cys Leu Pro Arg His Ala Ala Pro Leu Gly Arg Pro His Asp 
225                 230                 235                 240 


Thr Thr Gly Phe Pro Pro Ser Phe Gln Glu Ser Pro His Leu His Thr 
                245                 250                 255     


Gln Ser Lys Lys Ala Ala Gln Thr Pro Cys Glu Thr Ala Ser Lys Tyr 
            260                 265                 270         


Met Cys Glu Tyr Ser Lys Leu Val Gly Asn Leu Leu Asp Phe Cys Phe 
        275                 280                 285             


Tyr Thr Phe Arg Glu Ser Gln Val Leu Lys Val Glu Phe Pro Glu Met 
    290                 295                 300                 


Leu Val Glu Ile Ile Ser Asp Gln Ile Pro Lys Val Glu Ser Gly Leu 
305                 310                 315                 320 


Thr His Thr Ile Tyr Phe His Lys Lys 
                325                 


<210>  85
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Glu Val Gln Leu Gly Leu Gly Arg Val Tyr Pro Arg Pro Pro Ser 
1               5                   10                  15      


Lys Thr Tyr Arg Gly Ala Phe Gln Asn Leu Phe Gln Ser Val Arg Glu 
            20                  25                  30          


Val Ile Gln Asn Pro Gly Pro Arg His Pro Glu Ala Ala Ser Ala Ala 
        35                  40                  45              


Pro Pro Gly Ala Ser Leu Leu Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Thr 
65                  70                  75                  80  


Ser Pro Arg Gln Gln Gln Gln Gln Gln Gly Glu Asp Gly Ser Pro Gln 
                85                  90                  95      


Ala His Arg Arg Gly Pro Thr Gly Tyr Leu Val Leu Asp Glu Glu Gln 
            100                 105                 110         


Gln Pro Ser Gln Pro Gln Ser Ala Leu Glu Cys His Pro Glu Arg Gly 
        115                 120                 125             


Cys Val Pro Glu Pro Gly Ala Ala Val Ala Ala Ser Lys Gly Leu Pro 
    130                 135                 140                 


Gln Gln Leu Pro Ala Pro Pro Asp Glu Asp Asp Ser Ala Ala Pro Ser 
145                 150                 155                 160 


Thr Leu Ser Leu Leu Gly Pro Thr Phe Pro Gly Leu Ser Ser Cys Ser 
                165                 170                 175     


Ala Asp Leu Lys Asp Ile Leu Ser Glu Ala Ser Thr Met Gln Leu Leu 
            180                 185                 190         


Gln Gln Gln Gln Gln Glu Ala Val Ser Glu Gly Ser Ser Ser Gly Arg 
        195                 200                 205             


Ala Arg Glu Ala Ser Gly Ala Pro Thr Ser Ser Lys Asp Asn Tyr Leu 
    210                 215                 220                 


Gly Gly Thr Ser Thr Ile Ser Asp Asn Ala Lys Glu Leu Cys Lys Ala 
225                 230                 235                 240 


Val Ser Val Ser Met Gly Leu Gly Val Glu Ala Leu Glu His Leu Ser 
                245                 250                 255     


Pro Gly Glu Gln Leu Arg Gly Asp Cys Met Tyr Ala Pro Leu Leu Gly 
            260                 265                 270         


Val Pro Pro Ala Val Arg Pro Thr Pro Cys Ala Pro Leu Ala Glu Cys 
        275                 280                 285             


Lys Gly Ser Leu Leu Asp Asp Ser Ala Gly Lys Ser Thr Glu Asp Thr 
    290                 295                 300                 


Ala Glu Tyr Ser Pro Phe Lys Gly Gly Tyr Thr Lys Gly Leu Glu Gly 
305                 310                 315                 320 


Glu Ser Leu Gly Cys Ser Gly Ser Ala Ala Ala Gly Ser Ser Gly Thr 
                325                 330                 335     


Leu Glu Leu Pro Ser Thr Leu Ser Leu Tyr Lys Ser Gly Ala Leu Asp 
            340                 345                 350         


Glu Ala Ala Ala Tyr Gln Ser Arg Asp Tyr Tyr Asn Phe Pro Leu Ala 
        355                 360                 365             


Leu Ala Gly Pro Pro Pro Pro Pro Pro Pro Pro His Pro His Ala Arg 
    370                 375                 380                 


Ile Lys Leu Glu Asn Pro Leu Asp Tyr Gly Ser Ala Trp Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Gln Cys Arg Tyr Gly Asp Leu Ala Ser Leu His Gly Ala Gly 
                405                 410                 415     


Ala Ala Gly Pro Gly Ser Gly Ser Pro Ser Ala Ala Ala Ser Ser Ser 
            420                 425                 430         


Trp His Thr Leu Phe Thr Ala Glu Glu Gly Gln Leu Tyr Gly Pro Cys 
        435                 440                 445             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    450                 455                 460                 


Gly Gly Gly Gly Gly Gly Gly Gly Glu Ala Gly Ala Val Ala Pro Tyr 
465                 470                 475                 480 


Gly Tyr Thr Arg Pro Pro Gln Gly Leu Ala Gly Gln Glu Ser Asp Phe 
                485                 490                 495     


Thr Ala Pro Asp Val Trp Tyr Pro Gly Gly Met Val Ser Arg Val Pro 
            500                 505                 510         


Tyr Pro Ser Pro Thr Cys Val Lys Ser Glu Met Gly Pro Trp Met Asp 
        515                 520                 525             


Ser Tyr Ser Gly Pro Tyr Gly Asp Met Arg Leu Glu Thr Ala Arg Asp 
    530                 535                 540                 


His Val Leu Pro Ile Asp Tyr Tyr Phe Pro Pro Gln Lys Thr Cys Leu 
545                 550                 555                 560 


Ile Cys Gly Asp Glu Ala Ser Gly Cys His Tyr Gly Ala Leu Thr Cys 
                565                 570                 575     


Gly Ser Cys Lys Val Phe Phe Lys Arg Ala Ala Glu Gly Lys Gln Lys 
            580                 585                 590         


Tyr Leu Cys Ala Ser Arg Asn Asp Cys Thr Ile Asp Lys Phe Arg Arg 
        595                 600                 605             


Lys Asn Cys Pro Ser Cys Arg Leu Arg Lys Cys Tyr Glu Ala Gly Met 
    610                 615                 620                 


Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu Gly Asn Leu Lys Leu Gln 
625                 630                 635                 640 


Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser Pro Thr Glu Glu Thr Thr 
                645                 650                 655     


Gln Lys Leu Thr Val Ser His Ile Glu Gly Tyr Glu Cys Gln Pro Ile 
            660                 665                 670         


Phe Leu Asn Val Leu Glu Ala Ile Glu Pro Gly Val Val Cys Ala Gly 
        675                 680                 685             


His Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu 
    690                 695                 700                 


Asn Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys 
705                 710                 715                 720 


Ala Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val 
                725                 730                 735     


Ile Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg 
            740                 745                 750         


Ser Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu 
        755                 760                 765             


Val Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys 
    770                 775                 780                 


Val Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr 
785                 790                 795                 800 


Pro Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile 
                805                 810                 815     


Pro Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met 
            820                 825                 830         


Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn 
        835                 840                 845             


Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp 
    850                 855                 860                 


Ser Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu 
865                 870                 875                 880 


Leu Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala 
                885                 890                 895     


Glu Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys 
            900                 905                 910         


Pro Ile Tyr Phe His Thr Gln 
        915                 


<210>  86
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  86

Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu 
1               5                   10                  15      


Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser 
            20                  25                  30          


Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly 
        35                  40                  45              


Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro 
    50                  55                  60                  


Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His 
                85                  90                  95      


Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val 
            100                 105                 110         


Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val 
        115                 120                 125             


Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu 
    130                 135                 140                 


Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser 
145                 150                 155                 160 


Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe 
                165                 170                 175     


Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu 
            180                 185                 190         


Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe 
        195                 200                 205             


Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile 
    210                 215                 220                 


Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln 
225                 230                 235                 240 


Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His 
                245                 250                 255     


Gln Phe Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser Val Asp 
            260                 265                 270         


Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile 
        275                 280                 285             


Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
    290                 295                 300     


<210>  87
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  87

Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
1               5                   10                  15      


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
            20                  25                  30          


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
        35                  40                  45              


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
    50                  55                  60                  


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
65                  70                  75                  80  


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
                85                  90                  95      


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
            100                 105                 110         


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
        115                 120                 125             


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
145                 150                 155                 160 


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
                165                 170                 175     


Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Thr Phe Asp Leu Leu 
            180                 185                 190         


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
        195                 200                 205             


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
    210                 215                 220                 


Ile Tyr Phe His Thr Gln 
225                 230 


<210>  88
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  88

Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu 
1               5                   10                  15      


Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser 
            20                  25                  30          


Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly 
        35                  40                  45              


Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro 
    50                  55                  60                  


Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His 
                85                  90                  95      


Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val 
            100                 105                 110         


Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val 
        115                 120                 125             


Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu 
    130                 135                 140                 


Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser 
145                 150                 155                 160 


Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe 
                165                 170                 175     


Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu 
            180                 185                 190         


Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe 
        195                 200                 205             


Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile 
    210                 215                 220                 


Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln 
225                 230                 235                 240 


Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His 
                245                 250                 255     


Gln Phe Ala Phe Asp Leu Leu Ile Lys Ser His Met Val Ser Val Asp 
            260                 265                 270         


Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile 
        275                 280                 285             


Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
    290                 295                 300     


<210>  89
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  89

Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
1               5                   10                  15      


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
            20                  25                  30          


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
        35                  40                  45              


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
    50                  55                  60                  


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
65                  70                  75                  80  


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
                85                  90                  95      


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
            100                 105                 110         


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
        115                 120                 125             


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
145                 150                 155                 160 


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
                165                 170                 175     


Val Gln Pro Ile Ala Arg Glu Leu His Gln Phe Ala Phe Asp Leu Leu 
            180                 185                 190         


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
        195                 200                 205             


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
    210                 215                 220                 


Ile Tyr Phe His Thr Gln 
225                 230 


<210>  90
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  90

Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu 
1               5                   10                  15      


Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser 
            20                  25                  30          


Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly 
        35                  40                  45              


Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro 
    50                  55                  60                  


Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His 
                85                  90                  95      


Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val 
            100                 105                 110         


Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val 
        115                 120                 125             


Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu 
    130                 135                 140                 


Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser 
145                 150                 155                 160 


Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe 
                165                 170                 175     


Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu 
            180                 185                 190         


Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe 
        195                 200                 205             


Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile 
    210                 215                 220                 


Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln 
225                 230                 235                 240 


Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His 
                245                 250                 255     


Gln Leu Thr Phe Asp Leu Leu Ile Lys Ser His Met Val Ser Val Asp 
            260                 265                 270         


Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile 
        275                 280                 285             


Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
    290                 295                 300     


<210>  91
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  91

Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
1               5                   10                  15      


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
            20                  25                  30          


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
        35                  40                  45              


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
    50                  55                  60                  


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
65                  70                  75                  80  


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
                85                  90                  95      


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
            100                 105                 110         


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
        115                 120                 125             


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
145                 150                 155                 160 


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
                165                 170                 175     


Val Gln Pro Ile Ala Arg Glu Leu His Gln Leu Thr Phe Asp Leu Leu 
            180                 185                 190         


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
        195                 200                 205             


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
    210                 215                 220                 


Ile Tyr Phe His Thr Gln 
225                 230 


<210>  92
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  92

Cys Tyr Glu Ala Gly Met Thr Leu Gly Ala Arg Lys Leu Lys Lys Leu 
1               5                   10                  15      


Gly Asn Leu Lys Leu Gln Glu Glu Gly Glu Ala Ser Ser Thr Thr Ser 
            20                  25                  30          


Pro Thr Glu Glu Thr Thr Gln Lys Leu Thr Val Ser His Ile Glu Gly 
        35                  40                  45              


Tyr Glu Cys Gln Pro Ile Phe Leu Asn Val Leu Glu Ala Ile Glu Pro 
    50                  55                  60                  


Gly Val Val Cys Ala Gly His Asp Asn Asn Gln Pro Asp Ser Phe Ala 
65                  70                  75                  80  


Ala Leu Leu Ser Ser Leu Asn Glu Leu Gly Glu Arg Gln Leu Val His 
                85                  90                  95      


Val Val Lys Trp Ala Lys Ala Leu Pro Gly Phe Arg Asn Leu His Val 
            100                 105                 110         


Asp Asp Gln Met Ala Val Ile Gln Tyr Ser Trp Met Gly Leu Met Val 
        115                 120                 125             


Phe Ala Met Gly Trp Arg Ser Phe Thr Asn Val Asn Ser Arg Met Leu 
    130                 135                 140                 


Tyr Phe Ala Pro Asp Leu Val Phe Asn Glu Tyr Arg Met His Lys Ser 
145                 150                 155                 160 


Arg Met Tyr Ser Gln Cys Val Arg Met Arg His Leu Ser Gln Glu Phe 
                165                 170                 175     


Gly Trp Leu Gln Ile Thr Pro Gln Glu Phe Leu Cys Met Lys Ala Leu 
            180                 185                 190         


Leu Leu Phe Ser Ile Ile Pro Val Asp Gly Leu Lys Asn Gln Lys Phe 
        195                 200                 205             


Phe Asp Glu Leu Arg Met Asn Tyr Ile Lys Glu Leu Asp Arg Ile Ile 
    210                 215                 220                 


Ala Cys Lys Arg Lys Asn Pro Thr Ser Cys Ser Arg Arg Phe Tyr Gln 
225                 230                 235                 240 


Leu Thr Lys Leu Leu Asp Ser Val Gln Pro Ile Ala Arg Glu Leu His 
                245                 250                 255     


Gln Leu Ala Phe Asp Leu Leu Ile Lys Ser His Met Val Ser Val Asp 
            260                 265                 270         


Phe Pro Glu Met Met Ala Glu Ile Ile Ser Val Gln Val Pro Lys Ile 
        275                 280                 285             


Leu Ser Gly Lys Val Lys Pro Ile Tyr Phe His Thr Gln 
    290                 295                 300     


<210>  93
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  93

Asp Asn Asn Gln Pro Asp Ser Phe Ala Ala Leu Leu Ser Ser Leu Asn 
1               5                   10                  15      


Glu Leu Gly Glu Arg Gln Leu Val His Val Val Lys Trp Ala Lys Ala 
            20                  25                  30          


Leu Pro Gly Phe Arg Asn Leu His Val Asp Asp Gln Met Ala Val Ile 
        35                  40                  45              


Gln Tyr Ser Trp Met Gly Leu Met Val Phe Ala Met Gly Trp Arg Ser 
    50                  55                  60                  


Phe Thr Asn Val Asn Ser Arg Met Leu Tyr Phe Ala Pro Asp Leu Val 
65                  70                  75                  80  


Phe Asn Glu Tyr Arg Met His Lys Ser Arg Met Tyr Ser Gln Cys Val 
                85                  90                  95      


Arg Met Arg His Leu Ser Gln Glu Phe Gly Trp Leu Gln Ile Thr Pro 
            100                 105                 110         


Gln Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Phe Ser Ile Ile Pro 
        115                 120                 125             


Val Asp Gly Leu Lys Asn Gln Lys Phe Phe Asp Glu Leu Arg Met Asn 
    130                 135                 140                 


Tyr Ile Lys Glu Leu Asp Arg Ile Ile Ala Cys Lys Arg Lys Asn Pro 
145                 150                 155                 160 


Thr Ser Cys Ser Arg Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Ser 
                165                 170                 175     


Val Gln Pro Ile Ala Arg Glu Leu His Gln Leu Ala Phe Asp Leu Leu 
            180                 185                 190         


Ile Lys Ser His Met Val Ser Val Asp Phe Pro Glu Met Met Ala Glu 
        195                 200                 205             


Ile Ile Ser Val Gln Val Pro Lys Ile Leu Ser Gly Lys Val Lys Pro 
    210                 215                 220                 


Ile Tyr Phe His Thr Gln 
225                 230 


<210>  94
<211>  933
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Thr Glu Leu Lys Ala Lys Gly Pro Arg Ala Pro His Val Ala Gly 
1               5                   10                  15      


Gly Pro Pro Ser Pro Glu Val Gly Ser Pro Leu Leu Cys Arg Pro Ala 
            20                  25                  30          


Ala Gly Pro Phe Pro Gly Ser Gln Thr Ser Asp Thr Leu Pro Glu Val 
        35                  40                  45              


Ser Ala Ile Pro Ile Ser Leu Asp Gly Leu Leu Phe Pro Arg Pro Cys 
    50                  55                  60                  


Gln Gly Gln Asp Pro Ser Asp Glu Lys Thr Gln Asp Gln Gln Ser Leu 
65                  70                  75                  80  


Ser Asp Val Glu Gly Ala Tyr Ser Arg Ala Glu Ala Thr Arg Gly Ala 
                85                  90                  95      


Gly Gly Ser Ser Ser Ser Pro Pro Glu Lys Asp Ser Gly Leu Leu Asp 
            100                 105                 110         


Ser Val Leu Asp Thr Leu Leu Ala Pro Ser Gly Pro Gly Gln Ser Gln 
        115                 120                 125             


Pro Ser Pro Pro Ala Cys Glu Val Thr Ser Ser Trp Cys Leu Phe Gly 
    130                 135                 140                 


Pro Glu Leu Pro Glu Asp Pro Pro Ala Ala Pro Ala Thr Gln Arg Val 
145                 150                 155                 160 


Leu Ser Pro Leu Met Ser Arg Ser Gly Cys Lys Val Gly Asp Ser Ser 
                165                 170                 175     


Gly Thr Ala Ala Ala His Lys Val Leu Pro Arg Gly Leu Ser Pro Ala 
            180                 185                 190         


Arg Gln Leu Leu Leu Pro Ala Ser Glu Ser Pro His Trp Ser Gly Ala 
        195                 200                 205             


Pro Val Lys Pro Ser Pro Gln Ala Ala Ala Val Glu Val Glu Glu Glu 
    210                 215                 220                 


Asp Gly Ser Glu Ser Glu Glu Ser Ala Gly Pro Leu Leu Lys Gly Lys 
225                 230                 235                 240 


Pro Arg Ala Leu Gly Gly Ala Ala Ala Gly Gly Gly Ala Ala Ala Val 
                245                 250                 255     


Pro Pro Gly Ala Ala Ala Gly Gly Val Ala Leu Val Pro Lys Glu Asp 
            260                 265                 270         


Ser Arg Phe Ser Ala Pro Arg Val Ala Leu Val Glu Gln Asp Ala Pro 
        275                 280                 285             


Met Ala Pro Gly Arg Ser Pro Leu Ala Thr Thr Val Met Asp Phe Ile 
    290                 295                 300                 


His Val Pro Ile Leu Pro Leu Asn His Ala Leu Leu Ala Ala Arg Thr 
305                 310                 315                 320 


Arg Gln Leu Leu Glu Asp Glu Ser Tyr Asp Gly Gly Ala Gly Ala Ala 
                325                 330                 335     


Ser Ala Phe Ala Pro Pro Arg Ser Ser Pro Cys Ala Ser Ser Thr Pro 
            340                 345                 350         


Val Ala Val Gly Asp Phe Pro Asp Cys Ala Tyr Pro Pro Asp Ala Glu 
        355                 360                 365             


Pro Lys Asp Asp Ala Tyr Pro Leu Tyr Ser Asp Phe Gln Pro Pro Ala 
    370                 375                 380                 


Leu Lys Ile Lys Glu Glu Glu Glu Gly Ala Glu Ala Ser Ala Arg Ser 
385                 390                 395                 400 


Pro Arg Ser Tyr Leu Val Ala Gly Ala Asn Pro Ala Ala Phe Pro Asp 
                405                 410                 415     


Phe Pro Leu Gly Pro Pro Pro Pro Leu Pro Pro Arg Ala Thr Pro Ser 
            420                 425                 430         


Arg Pro Gly Glu Ala Ala Val Thr Ala Ala Pro Ala Ser Ala Ser Val 
        435                 440                 445             


Ser Ser Ala Ser Ser Ser Gly Ser Thr Leu Glu Cys Ile Leu Tyr Lys 
    450                 455                 460                 


Ala Glu Gly Ala Pro Pro Gln Gln Gly Pro Phe Ala Pro Pro Pro Cys 
465                 470                 475                 480 


Lys Ala Pro Gly Ala Ser Gly Cys Leu Leu Pro Arg Asp Gly Leu Pro 
                485                 490                 495     


Ser Thr Ser Ala Ser Ala Ala Ala Ala Gly Ala Ala Pro Ala Leu Tyr 
            500                 505                 510         


Pro Ala Leu Gly Leu Asn Gly Leu Pro Gln Leu Gly Tyr Gln Ala Ala 
        515                 520                 525             


Val Leu Lys Glu Gly Leu Pro Gln Val Tyr Pro Pro Tyr Leu Asn Tyr 
    530                 535                 540                 


Leu Arg Pro Asp Ser Glu Ala Ser Gln Ser Pro Gln Tyr Ser Phe Glu 
545                 550                 555                 560 


Ser Leu Pro Gln Lys Ile Cys Leu Ile Cys Gly Asp Glu Ala Ser Gly 
                565                 570                 575     


Cys His Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys 
            580                 585                 590         


Arg Ala Met Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp 
        595                 600                 605             


Cys Ile Val Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Leu 
    610                 615                 620                 


Arg Lys Cys Cys Gln Ala Gly Met Val Leu Gly Gly Arg Lys Phe Lys 
625                 630                 635                 640 


Lys Phe Asn Lys Val Arg Val Val Arg Ala Leu Asp Ala Val Ala Leu 
                645                 650                 655     


Pro Gln Pro Val Gly Val Pro Asn Glu Ser Gln Ala Leu Ser Gln Arg 
            660                 665                 670         


Phe Thr Phe Ser Pro Gly Gln Asp Ile Gln Leu Ile Pro Pro Leu Ile 
        675                 680                 685             


Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala Gly His Asp 
    690                 695                 700                 


Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser Leu Asn Gln 
705                 710                 715                 720 


Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser Lys Ser Leu 
                725                 730                 735     


Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr Leu Ile Gln 
            740                 745                 750         


Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp Arg Ser Tyr 
        755                 760                 765             


Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp Leu Ile Leu 
    770                 775                 780                 


Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu Cys Leu Thr 
785                 790                 795                 800 


Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val Ser Gln Glu 
                805                 810                 815     


Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr Ile Pro Leu 
            820                 825                 830         


Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg Ser Ser Tyr 
        835                 840                 845             


Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys Gly Val Val 
    850                 855                 860                 


Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu Asp Asn Leu 
865                 870                 875                 880 


His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn Thr Phe Ile 
                885                 890                 895     


Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met Ser Glu Val 
            900                 905                 910         


Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val Lys Pro Leu 
        915                 920                 925             


Leu Phe His Lys Lys 
    930             


<210>  95
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  95

Gly Gln Asp Ile Gln Leu Ile Pro Pro Leu Ile Asn Leu Leu Met Ser 
1               5                   10                  15      


Ile Glu Pro Asp Val Ile Tyr Ala Gly His Asp Asn Thr Lys Pro Asp 
            20                  25                  30          


Thr Ser Ser Ser Leu Leu Thr Ser Leu Asn Gln Leu Gly Glu Arg Gln 
        35                  40                  45              


Leu Leu Ser Val Val Lys Trp Ser Lys Ser Leu Pro Gly Phe Arg Asn 
    50                  55                  60                  


Leu His Ile Asp Asp Gln Ile Thr Leu Ile Gln Tyr Ser Trp Met Ser 
65                  70                  75                  80  


Leu Met Val Phe Gly Leu Gly Trp Arg Ser Tyr Lys His Val Ser Gly 
                85                  90                  95      


Gln Met Leu Tyr Phe Ala Pro Asp Leu Ile Leu Asn Glu Gln Arg Met 
            100                 105                 110         


Lys Glu Ser Ser Phe Tyr Ser Leu Cys Leu Thr Met Trp Gln Ile Pro 
        115                 120                 125             


Gln Glu Phe Val Lys Leu Gln Val Ser Gln Glu Glu Phe Leu Cys Met 
    130                 135                 140                 


Lys Val Leu Leu Leu Leu Asn Thr Ile Pro Leu Glu Gly Leu Arg Ser 
145                 150                 155                 160 


Gln Thr Gln Phe Glu Glu Met Arg Ser Ser Tyr Ile Arg Glu Leu Ile 
                165                 170                 175     


Lys Ala Ile Gly Leu Arg Gln Lys Gly Val Val Ser Ser Ser Gln Arg 
            180                 185                 190         


Phe Tyr Gln Leu Thr Lys Leu Leu Asp Asn Leu His Asp Leu Val Lys 
        195                 200                 205             


Gln Leu His Leu Tyr Cys Leu Asn Thr Phe Ile Gln Ser Arg Ala Leu 
    210                 215                 220                 


Ser Val Glu Phe Pro Glu Met Met Ser Glu Val Ile Ala Ala Gln Leu 
225                 230                 235                 240 


Pro Lys Ile Leu Ala Gly Met Val Lys Pro Leu Leu Phe His Lys Lys 
                245                 250                 255     


<210>  96
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  96

Pro Leu Ile Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala 
1               5                   10                  15      


Gly His Asp Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser 
            20                  25                  30          


Leu Asn Gln Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu 
            100                 105                 110         


Cys Leu Thr Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val 
        115                 120                 125             


Ser Gln Glu Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg 
145                 150                 155                 160 


Ser Ser Tyr Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys 
                165                 170                 175     


Gly Val Val Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Asn Leu His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn 
        195                 200                 205             


Thr Phe Ile Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Leu Phe His Lys Lys 
                245             


<210>  97
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  97

Pro Leu Ile Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala 
1               5                   10                  15      


Gly His Asp Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser 
            20                  25                  30          


Leu Asn Gln Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu 
            100                 105                 110         


Cys Leu Thr Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val 
        115                 120                 125             


Ser Gln Glu Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg 
145                 150                 155                 160 


Ser Ser Tyr Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys 
                165                 170                 175     


Gly Val Val Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Asn Leu His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn 
        195                 200                 205             


Thr Phe Ile Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Leu Phe His Lys Lys 
                245             


<210>  98
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  98

Pro Met Ile Ser Val Leu Arg Gly Ile Glu Pro Glu Val Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Asn Thr Lys Pro Glu Thr Pro Ser Ser Leu Leu Thr Ser 
            20                  25                  30          


Leu Asn His Leu Cys Glu Arg Gln Leu Leu Cys Val Val Lys Trp Ser 
        35                  40                  45              


Lys Leu Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Met Val Phe Ala Met Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu 
            100                 105                 110         


Cys Leu Ser Met Trp Gln Leu Pro Gln Glu Phe Val Arg Leu Gln Val 
        115                 120                 125             


Ser Gln Glu Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Arg Ser Gln Ser Gln Phe Asp Glu Met Arg 
145                 150                 155                 160 


Thr Ser Tyr Ile Arg Glu Leu Val Lys Ala Ile Gly Leu Arg Gln Lys 
                165                 170                 175     


Gly Val Val Ala Asn Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Met 
            180                 185                 190         


Asp Ser Met His Asp Leu Val Lys Gln Leu His Leu Phe Cys Leu Asn 
        195                 200                 205             


Thr Phe Leu Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Leu Phe His Lys Lys 
                245             


<210>  99
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  99

Glu Leu Leu Gln Ile Leu Gln Ser Ile Glu Pro Glu Val Val Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Asn Thr Gln Pro Glu Thr Pro Ser Ala Leu Leu Ser Ser 
            20                  25                  30          


Leu Asn Gln Leu Cys Glu Arg Gln Leu Val Cys Val Val Lys Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Ser Leu Met Val Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Gln His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Asp Ser Ser Phe Tyr Thr Leu 
            100                 105                 110         


Cys Leu Ser Met Trp Gln Leu Pro Gln Glu Phe Met Lys Leu Gln Val 
        115                 120                 125             


Thr His Glu Glu Phe Leu Cys Met Lys Ala Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Lys Ser Gln Thr Asn Phe Asp Glu Met Arg 
145                 150                 155                 160 


Ser Asn Tyr Ile Arg Glu Leu Ala Lys Ala Ile Ser Leu Arg His Lys 
                165                 170                 175     


Gly Val Ile Ala Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Met 
            180                 185                 190         


Asp Ser Met His Glu Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn 
        195                 200                 205             


Thr Phe Leu Gln Ser Arg Ser Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ser Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Val Phe His Lys Lys 
                245             


<210>  100
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  100

Gln Met Ile Ser Ile Leu Glu Asn Ile Glu Pro Gln Val Val Tyr Ser 
1               5                   10                  15      


Gly Tyr Asp Asn Thr Gln Pro Glu Val Pro His Leu Leu Leu Asn Ser 
            20                  25                  30          


Leu Asn Arg Leu Cys Glu Arg Gln Leu Leu Trp Ile Val Arg Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asn Asp Gln Met Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Gly Leu Met Leu Phe Ser Leu Gly Trp 
65                  70                  75                  80  


Arg Thr Phe Gln Asn Val Thr Pro Asp Tyr Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Leu Ser Asn Asp Gln Leu Arg Arg Ser Pro Ile Tyr Asp Leu 
            100                 105                 110         


Cys Leu Ala Met Gln Phe Val Pro Gln Glu Phe Ala Asn Leu Gln Val 
        115                 120                 125             


Thr Lys Glu Glu Phe Leu Cys Met Lys Ala Leu Met Leu Leu Asn Thr 
    130                 135                 140                 


Val Pro Leu Glu Gly Leu Lys Ser Gln Thr Gln Phe Asp Glu Met Arg 
145                 150                 155                 160 


Gln Asn Tyr Ile Cys Glu Leu Ser Lys Ala Ile Gln Leu Lys Glu Lys 
                165                 170                 175     


Gly Val Val Ala Ser Ser Gln Arg Phe Tyr His Leu Thr Lys Leu Met 
            180                 185                 190         


Asp Asn Met His Glu Ile Val Lys Lys Val Asn Leu Tyr Cys Leu Ser 
        195                 200                 205             


Thr Phe Ile Gln Ala Asp Ala Met Lys Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Thr Glu Val Ile Ala Ser Gln Leu Pro Lys Val Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Met Phe His His Lys 
                245             


<210>  101
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  101

Pro Leu Ile Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala 
1               5                   10                  15      


Gly His Asp Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser 
            20                  25                  30          


Leu Asn Gln Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu 
            100                 105                 110         


Cys Leu Thr Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val 
        115                 120                 125             


Ser Gln Glu Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg 
145                 150                 155                 160 


Ser Ser Tyr Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys 
                165                 170                 175     


Gly Val Val Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Asn Leu His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn 
        195                 200                 205             


Thr Phe Ile Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Leu Phe His Lys Lys 
                245             


<210>  102
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  102

Pro Leu Ile Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala 
1               5                   10                  15      


Gly His Asp Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser 
            20                  25                  30          


Leu Asn Gln Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu 
            100                 105                 110         


Cys Leu Thr Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val 
        115                 120                 125             


Ser Gln Glu Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg 
145                 150                 155                 160 


Ser Ser Tyr Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys 
                165                 170                 175     


Gly Val Val Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Asn Leu His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn 
        195                 200                 205             


Thr Phe Ile Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Leu Phe His Lys Lys 
                245             


<210>  103
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  103

Pro Leu Ile Asn Leu Leu Met Ser Ile Glu Pro Asp Val Ile Tyr Ala 
1               5                   10                  15      


Gly His Asp Asn Thr Lys Pro Asp Thr Ser Ser Ser Leu Leu Thr Ser 
            20                  25                  30          


Leu Asn Gln Leu Gly Glu Arg Gln Leu Leu Ser Val Val Lys Trp Ser 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Ile Asp Asp Gln Ile Thr 
    50                  55                  60                  


Leu Ile Gln Tyr Ser Trp Met Ser Leu Met Val Phe Gly Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys His Val Ser Gly Gln Met Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Leu Asn Glu Gln Arg Met Lys Glu Ser Ser Phe Tyr Ser Leu 
            100                 105                 110         


Cys Leu Thr Met Trp Gln Ile Pro Gln Glu Phe Val Lys Leu Gln Val 
        115                 120                 125             


Ser Gln Glu Glu Phe Leu Cys Met Lys Val Leu Leu Leu Leu Asn Thr 
    130                 135                 140                 


Ile Pro Leu Glu Gly Leu Arg Ser Gln Thr Gln Phe Glu Glu Met Arg 
145                 150                 155                 160 


Ser Ser Tyr Ile Arg Glu Leu Ile Lys Ala Ile Gly Leu Arg Gln Lys 
                165                 170                 175     


Gly Val Val Ser Ser Ser Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Asn Leu His Asp Leu Val Lys Gln Leu His Leu Tyr Cys Leu Asn 
        195                 200                 205             


Thr Phe Ile Gln Ser Arg Ala Leu Ser Val Glu Phe Pro Glu Met Met 
    210                 215                 220                 


Ser Glu Val Ile Ala Ala Gln Leu Pro Lys Ile Leu Ala Gly Met Val 
225                 230                 235                 240 


Lys Pro Leu Leu Phe His Lys Lys 
                245             


<210>  104
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Thr Pro Asn Ser Met Thr Glu Asn Gly Leu Thr Ala Trp Asp Lys 
1               5                   10                  15      


Pro Lys His Cys Pro Asp Arg Glu His Asp Trp Lys Leu Val Gly Met 
            20                  25                  30          


Ser Glu Ala Cys Leu His Arg Lys Ser His Ser Glu Arg Arg Ser Thr 
        35                  40                  45              


Leu Lys Asn Glu Gln Ser Ser Pro His Leu Ile Gln Thr Thr Trp Thr 
    50                  55                  60                  


Ser Ser Ile Phe His Leu Asp His Asp Asp Val Asn Asp Gln Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gln Thr Phe Gln Thr Glu Glu Lys Lys Cys Lys Gly Tyr 
                85                  90                  95      


Ile Pro Ser Tyr Leu Asp Lys Asp Glu Leu Cys Val Val Cys Gly Asp 
            100                 105                 110         


Lys Ala Thr Gly Tyr His Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys 
        115                 120                 125             


Gly Phe Phe Arg Arg Thr Ile Gln Lys Asn Leu His Pro Ser Tyr Ser 
    130                 135                 140                 


Cys Lys Tyr Glu Gly Lys Cys Val Ile Asp Lys Val Thr Arg Asn Gln 
145                 150                 155                 160 


Cys Gln Glu Cys Arg Phe Lys Lys Cys Ile Tyr Val Gly Met Ala Thr 
                165                 170                 175     


Asp Leu Val Leu Asp Asp Ser Lys Arg Leu Ala Lys Arg Lys Leu Ile 
            180                 185                 190         


Glu Glu Asn Arg Glu Lys Arg Arg Arg Glu Glu Leu Gln Lys Ser Ile 
        195                 200                 205             


Gly His Lys Pro Glu Pro Thr Asp Glu Glu Trp Glu Leu Ile Lys Thr 
    210                 215                 220                 


Val Thr Glu Ala His Val Ala Thr Asn Ala Gln Gly Ser His Trp Lys 
225                 230                 235                 240 


Gln Lys Arg Lys Phe Leu Pro Glu Asp Ile Gly Gln Ala Pro Ile Val 
                245                 250                 255     


Asn Ala Pro Glu Gly Gly Lys Val Asp Leu Glu Ala Phe Ser His Phe 
            260                 265                 270         


Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe Ala Lys 
        275                 280                 285             


Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu 
    290                 295                 300                 


Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala Val Arg 
305                 310                 315                 320 


Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Asn Gly Glu Met Ala Val 
                325                 330                 335     


Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser Asp Ala 
            340                 345                 350         


Ile Phe Asp Leu Gly Met Ser Leu Ser Ser Phe Asn Leu Asp Asp Thr 
        355                 360                 365             


Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser Asp Arg Pro 
    370                 375                 380                 


Gly Leu Ala Cys Val Glu Arg Ile Glu Lys Tyr Gln Asp Ser Phe Leu 
385                 390                 395                 400 


Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His His Val Thr His 
                405                 410                 415     


Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly 
            420                 425                 430         


Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Thr 
        435                 440                 445             


Glu Leu Phe Pro Pro Leu Phe Leu Glu Val Phe Glu Asp 
    450                 455                 460     


<210>  105
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  105

Glu Glu Leu Gln Lys Ser Ile Gly His Lys Pro Glu Pro Thr Asp Glu 
1               5                   10                  15      


Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala Thr Asn 
            20                  25                  30          


Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro Glu Asp 
        35                  40                  45              


Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys Val Asp 
    50                  55                  60                  


Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala Ile Thr 
65                  70                  75                  80  


Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu Leu Pro 
                85                  90                  95      


Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu Ile Met 
            100                 105                 110         


Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr Leu Thr 
        115                 120                 125             


Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn Gly Gly 
    130                 135                 140                 


Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser Leu Ser 
145                 150                 155                 160 


Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala Val Leu 
                165                 170                 175     


Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg Ile Glu 
            180                 185                 190         


Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile Asn Tyr 
        195                 200                 205             


Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met Lys Val 
    210                 215                 220                 


Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe Leu His 
225                 230                 235                 240 


Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe Leu Glu 
                245                 250                 255     


Val Phe Glu Asp 
            260 


<210>  106
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  106

Asp Asp Ser Lys Arg Leu Ala Lys Arg Lys Leu Ile Glu Glu Asn Arg 
1               5                   10                  15      


Glu Lys Arg Arg Arg Glu Glu Leu Gln Lys Ser Ile Gly His Lys Pro 
            20                  25                  30          


Glu Pro Thr Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala 
        35                  40                  45              


His Val Ala Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys 
    50                  55                  60                  


Phe Leu Pro Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu 
65                  70                  75                  80  


Gly Gly Lys Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile 
                85                  90                  95      


Thr Pro Ala Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met 
            100                 105                 110         


Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys 
        115                 120                 125             


Cys Met Glu Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu 
    130                 135                 140                 


Ser Glu Thr Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln 
145                 150                 155                 160 


Leu Lys Asn Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu 
                165                 170                 175     


Gly Met Ser Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu 
            180                 185                 190         


Leu Gln Ala Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys 
        195                 200                 205             


Val Glu Arg Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu 
    210                 215                 220                 


His Tyr Ile Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys 
225                 230                 235                 240 


Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala 
                245                 250                 255     


Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro 
            260                 265                 270         


Pro Leu Phe Leu Glu Val Phe Glu Asp 
        275                 280     


<210>  107
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  107

Pro Glu Glu Trp Asp Leu Ile His Ile Ala Thr Glu Ala His Arg Ser 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu Pro 
            20                  25                  30          


Asp Asp Ile Gly Gln Ser Pro Ile Val Ser Met Pro Asp Gly Asp Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Ser Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Asp Thr 
            100                 105                 110         


Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Glu Leu Gly Lys Ser 
    130                 135                 140                 


Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Thr Asp Arg Ser Gly Leu Leu Cys Val Asp Lys 
                165                 170                 175     


Ile Glu Lys Ser Gln Glu Ala Tyr Leu Leu Ala Phe Glu His Tyr Val 
            180                 185                 190         


Asn His Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  108
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  108

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  109
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  109

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  110
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  110

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Arg Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  111
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  111

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Arg Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  112
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  112

Thr Cys Pro Lys Lys Val Asn Arg Tyr Tyr Leu Asn Gly Ser Pro Lys 
1               5                   10                  15      


Pro Gly Met Pro Val Pro Glu Ala Pro Arg Pro Pro Val Val Gln Asn 
            20                  25                  30          


Gly Val Val Arg Glu Ala Asp Ser Ser Gly Ala Met Asp Asp Asp Met 
        35                  40                  45              


Val Asp Gln Asp Ile Phe Ser His Leu Ala Glu Val Ile Thr Pro Ala 
    50                  55                  60                  


Ile Ile Lys Val Val Glu Phe Ala Lys Gln Ile Pro Gly Phe Thr Lys 
65                  70                  75                  80  


Leu Val Pro Asp Asp Gln Val Ala Leu Leu Lys Asn Cys Cys Phe Glu 
                85                  90                  95      


Val Met Cys Leu Arg Ala Ala Ser Arg Phe Asp Lys Gln Arg Arg Thr 
            100                 105                 110         


Ile Thr Met Phe Gly Gly Leu Thr Val Thr Lys Glu Gln Val Ser Gln 
        115                 120                 125             


Gly Gly Leu Gly Arg Leu Ala Glu Pro Leu Phe Glu Phe Ala Glu Gly 
    130                 135                 140                 


Leu Ser Gln Leu His Leu Asp Asp Thr Glu Val Ala Leu Leu Ala Ala 
145                 150                 155                 160 


Leu Leu Val Val Ala Asp Arg Pro Gly Val Gln Asp Gln Glu Ser Ile 
                165                 170                 175     


Asp Arg Leu Gln Asp Ile Ile Leu Thr Ala Tyr Lys Asn Tyr Ile Thr 
            180                 185                 190         


Arg Gln Arg Pro His Gln Pro Val Leu Trp Gly Lys Ile Leu Met Lys 
        195                 200                 205             


Val Thr Asp Leu Arg Ala Leu Ser Val Ala His Ala Glu Gln Val Lys 
    210                 215                 220                 


Leu Val Lys Met Glu Cys Thr Asn Asp Ile Pro Pro Leu Phe Leu Glu 
225                 230                 235                 240 


Met 
    


<210>  113
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  113

Ala Glu Glu Trp Glu Leu Ile His Val Val Thr Glu Ala His Arg Ser 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ser Pro Met Ala Ser Met Pro Asp Gly Asp Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Ser Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Lys Ser 
    130                 135                 140                 


Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Thr Gly Leu Ile Cys Val Asp Lys 
                165                 170                 175     


Ile Glu Lys Cys Gln Glu Thr Tyr Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  114
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  114

Ser Glu Glu Trp Glu Leu Ile Arg Ile Val Thr Glu Ala His Arg Ser 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ser Pro Met Ala Ser Met Pro Asp Gly Asp Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Ser Glu 
65                  70                  75                  80  


Leu Thr Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Asp Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Arg Ser 
    130                 135                 140                 


Leu Ala Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Thr Gly Leu Ile Cys Thr Asp Lys 
                165                 170                 175     


Ile Glu Lys Cys Gln Glu Thr Tyr Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn His Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  115
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  115

Ser Asp Pro Ser Gly Leu Ile Pro Asp Pro Leu Leu Asp Ser Arg Ala 
1               5                   10                  15      


Thr Ser Ser Thr Phe Pro Gln Leu Leu Thr Cys Pro Ile Leu Arg Pro 
            20                  25                  30          


Gly Phe Ser Arg Pro Ala Asp Ala Pro Pro Asp Lys Ile Gly Gln Ser 
        35                  40                  45              


Pro Val Ala Pro Thr Ser Asp Gly Asp Lys Val Asp Leu Glu Ala Phe 
    50                  55                  60                  


Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp 
65                  70                  75                  80  


Phe Ala Lys Lys Leu Pro Met Phe Ser Glu Leu Pro Cys Glu Asp Gln 
                85                  90                  95      


Ile Ile Leu Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala 
            100                 105                 110         


Ala Met Arg Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Ser Gly Glu 
        115                 120                 125             


Met Ala Val Lys Arg Glu Gln Leu Lys Asn Gly Gly Leu Gly Val Val 
    130                 135                 140                 


Ser Asp Ala Ile Phe Asp Leu Gly Lys Ser Leu Ala Gln Phe Asn Leu 
145                 150                 155                 160 


Asp Asp Thr Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser 
                165                 170                 175     


Gly Asn Arg Arg Arg Gly Arg Pro Arg Pro Ser Pro Ala Pro Gly Ser 
            180                 185                 190         


Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Arg Ser Gly Leu 
        195                 200                 205             


Thr Cys Thr Asp Lys Ile Glu Lys Cys Gln Glu Thr Tyr Leu Leu Ala 
    210                 215                 220                 


Phe Glu His Tyr Ile Asn Tyr Arg Lys His Asn Ile Pro His Phe Trp 
225                 230                 235                 240 


Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys 
                245                 250                 255     


His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Asn Glu Leu 
            260                 265                 270         


Phe Pro Pro Leu Phe Leu Glu Val 
        275                 280 


<210>  116
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  116

Asp His Glu Glu Ala Leu Ile Arg Ala Ile Leu Val Ala His Lys Gln 
1               5                   10                  15      


Thr Ser His Met Tyr Arg Arg Glu Ser Ser Ser Gly Glu Glu Ser Glu 
            20                  25                  30          


Pro Asp Ser Lys Lys Gln Lys Leu Glu Asp Glu Lys Pro Leu Ser Glu 
        35                  40                  45              


Ile Met Thr Pro Ser Ile Val Lys Val Val Glu Phe Ala Lys Arg Ile 
    50                  55                  60                  


Pro Gly Phe Thr Gly Leu His His Asp Asp Gln Ile Leu Leu Leu Lys 
65                  70                  75                  80  


Thr Cys Cys Met Glu Ile Met Cys Leu Arg Val Ala Gln Lys Phe Asp 
                85                  90                  95      


Pro Asp Ser Gln Lys Leu Ile Leu Ser Asn Gly Leu Arg Val Gly Lys 
            100                 105                 110         


Ser Asp Met Asp His Gly Val Leu Ser Glu Leu Ile Glu Pro Ile Phe 
        115                 120                 125             


Asp Phe Ala Val Ser Met Ser Arg Leu Gln Leu Thr Glu Thr Glu Met 
    130                 135                 140                 


Ala Leu Leu Ala Ala Val Leu Leu Ile Ala Gly Asp Arg Pro Gly Leu 
145                 150                 155                 160 


Lys Glu Ala Lys Leu Val Glu Thr Leu Gln Asp Ser Leu Leu Thr Ala 
                165                 170                 175     


Phe Gln His Phe Ile Asn Glu Ser Arg Pro Lys Thr Pro Val His Trp 
            180                 185                 190         


Ala Lys Ile Leu Met Lys Ile Thr Asp Leu Arg Thr Ile Ser Ala Arg 
        195                 200                 205             


His Ala Glu Arg Ile Met Cys Ile Lys Leu Asp Arg Pro Asn Glu Ile 
    210                 215                 220                 


Pro Gln Ile Phe Leu Glu Met 
225                 230     


<210>  117
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  117

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  118
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  118

Gln Glu Glu Trp Glu Met Ile Arg Val Val Thr Glu Ala His Met Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Asn His Trp Lys Gln Lys Arg Lys Phe Leu Ser 
            20                  25                  30          


Ala Val Gly Val Lys Glu Ala Lys Pro Glu Asp Ile Gly Ser Ala Pro 
        35                  40                  45              


Ile Val Asn Ala Pro Glu Gly Asn Lys Val Asp Ile Glu Ala Phe Ser 
    50                  55                  60                  


Gln Phe Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe 
65                  70                  75                  80  


Ala Lys Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile 
                85                  90                  95      


Ile Leu Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala 
            100                 105                 110         


Val Arg Tyr Asp Pro Glu Ser Asp Thr Leu Thr Leu Asn Gly Glu Met 
        115                 120                 125             


Ala Val Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser 
    130                 135                 140                 


Asp Ala Ile Phe Asp Leu Gly Val Ser Leu Ser Ser Phe Asn Leu Asp 
145                 150                 155                 160 


Asp Ser Glu Val Ala Leu Leu Gln Ala Val Ile Leu Leu Ser Ser Asp 
                165                 170                 175     


Arg Pro Gly Leu Thr Ser Val Glu Arg Ile Glu Arg Cys Gln Glu Glu 
            180                 185                 190         


Phe Leu Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His Lys Val 
        195                 200                 205             


Ala His Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met 
    210                 215                 220                 


Ile Gly Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys 
225                 230                 235                 240 


Pro Thr Glu Leu Phe Pro Pro Leu Phe Leu Glu Val 
                245                 250         


<210>  119
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  120
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  120

Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
1               5                   10                  15      


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
            20                  25                  30          


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
        35                  40                  45              


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
    50                  55                  60                  


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
65                  70                  75                  80  


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val 
                85                  90                  95      


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
            100                 105                 110         


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
        115                 120                 125             


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
    130                 135                 140                 


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
145                 150                 155                 160 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
                165                 170                 175     


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
            180                 185                 190         


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
        195                 200                 205             


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
    210                 215                 220                 


Lys Cys Lys Asn Val 
225                 


<210>  121
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  121

Ser Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met 
1               5                   10                  15      


Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp 
            20                  25                  30          


Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser 
        35                  40                  45              


Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu 
    50                  55                  60                  


Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala 
65                  70                  75                  80  


Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His 
                85                  90                  95      


Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp 
            100                 105                 110         


Arg Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu 
        115                 120                 125             


Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe 
    130                 135                 140                 


Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln 
145                 150                 155                 160 


Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly 
                165                 170                 175     


Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp 
            180                 185                 190         


His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu 
        195                 200                 205             


Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala 
    210                 215                 220                 


Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly 
225                 230                 235                 240 


Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr 
                245                 250                 255     


Asp Leu Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr 
            260                 265                 270         


Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala 
        275                 280                 285             


Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr 
    290                 295                 300                 


Gly Glu Ala Glu Gly Phe Pro Ala Thr Val 
305                 310                 


<210>  122
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  122

Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
1               5                   10                  15      


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser 
            20                  25                  30          


Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
        115                 120                 125             


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
145                 150                 155                 160 


Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
                165                 170                 175     


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
            180                 185                 190         


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  123
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  123

Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
1               5                   10                  15      


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
            20                  25                  30          


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Tyr Arg 
        35                  40                  45              


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
    50                  55                  60                  


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
65                  70                  75                  80  


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val 
                85                  90                  95      


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
            100                 105                 110         


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
        115                 120                 125             


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
    130                 135                 140                 


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
145                 150                 155                 160 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
                165                 170                 175     


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
            180                 185                 190         


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
        195                 200                 205             


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
    210                 215                 220                 


Lys Cys Lys Asn Val 
225                 


<210>  124
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  124

Ser Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met 
1               5                   10                  15      


Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp 
            20                  25                  30          


Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser 
        35                  40                  45              


Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu 
    50                  55                  60                  


Leu Thr Asn Leu Ala Tyr Arg Glu Leu Val His Met Ile Asn Trp Ala 
65                  70                  75                  80  


Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His 
                85                  90                  95      


Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp 
            100                 105                 110         


Arg Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu 
        115                 120                 125             


Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe 
    130                 135                 140                 


Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln 
145                 150                 155                 160 


Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly 
                165                 170                 175     


Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp 
            180                 185                 190         


His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu 
        195                 200                 205             


Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala 
    210                 215                 220                 


Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly 
225                 230                 235                 240 


Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr 
                245                 250                 255     


Asp Leu Leu Leu Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr 
            260                 265                 270         


Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala 
        275                 280                 285             


Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr 
    290                 295                 300                 


Gly Glu Ala Glu Gly Phe Pro Ala Thr Val 
305                 310                 


<210>  125
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  125

Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
1               5                   10                  15      


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser 
            20                  25                  30          


Met Met Gly Leu Leu Thr Asn Leu Ala Tyr Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
        115                 120                 125             


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
145                 150                 155                 160 


Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
                165                 170                 175     


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
            180                 185                 190         


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  126
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  126

Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
1               5                   10                  15      


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser 
            20                  25                  30          


Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
        115                 120                 125             


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
145                 150                 155                 160 


Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
                165                 170                 175     


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
            180                 185                 190         


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  127
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  127

Leu Ser Pro Glu Gln Leu Val Leu Thr Leu Leu Glu Ala Glu Pro Pro 
1               5                   10                  15      


His Val Leu Ile Ser Arg Pro Ser Ala Pro Phe Thr Glu Ala Ser Met 
            20                  25                  30          


Met Met Ser Leu Thr Lys Leu Ala Asp Lys Glu Leu Val His Met Ile 
        35                  40                  45              


Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu Ser Leu Phe Asp 
    50                  55                  60                  


Gln Val Arg Leu Leu Glu Ser Cys Trp Met Glu Val Leu Met Met Gly 
65                  70                  75                  80  


Leu Met Trp Arg Ser Ile Asp His Pro Gly Lys Leu Ile Phe Ala Pro 
                85                  90                  95      


Asp Leu Val Leu Asp Arg Asp Glu Gly Lys Cys Val Glu Gly Ile Leu 
            100                 105                 110         


Glu Ile Phe Asp Met Leu Leu Ala Thr Thr Ser Arg Phe Arg Glu Leu 
        115                 120                 125             


Lys Leu Gln His Lys Glu Tyr Leu Cys Val Lys Ala Met Ile Leu Leu 
    130                 135                 140                 


Asn Ser Ser Met Tyr Pro Leu Val Thr Ala Thr Gln Asp Ala Asp Ser 
145                 150                 155                 160 


Ser Arg Lys Leu Ala His Leu Leu Asn Ala Val Thr Asp Ala Leu Val 
                165                 170                 175     


Trp Val Ile Ala Lys Ser Gly Ile Ser Ser Gln Gln Gln Ser Met Arg 
            180                 185                 190         


Leu Ala Asn Leu Leu Met Leu Leu Ser His Val Arg His Ala Ser Asn 
        195                 200                 205             


Lys Gly Met Glu His Leu Leu Asn Met Lys Cys Lys Asn Val Val Pro 
    210                 215                 220                 


Val Tyr Asp Leu Leu Leu Glu Met Leu Asn Ala His 
225                 230                 235     


<210>  128
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  128

Asn Pro Thr Val Pro Leu Ile Ser His Leu Val Asn Ile Glu Pro Asn 
1               5                   10                  15      


Pro Ile Leu Thr Gly Tyr Asn Pro Gln Cys Thr Pro Thr Glu Gly Tyr 
            20                  25                  30          


Leu Met Ala Leu Val Thr Asp Leu Ala Asn Arg Glu Ile Glu Gly Leu 
        35                  40                  45              


Val Asp Trp Ala Ala Arg Leu Pro Gly Tyr Gly Met Leu Pro Met Asp 
    50                  55                  60                  


Asp Gln Val Asn Leu Ile Arg Thr Val Trp Leu Asp Leu Leu Met Leu 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Arg Gly Glu Trp Leu Val Phe 
                85                  90                  95      


Ala Pro Asp Leu Leu Met Asp Arg Ser Leu Cys Arg Leu Ser Gly Met 
            100                 105                 110         


Glu Tyr Ile Cys Thr Pro Met Leu Glu Phe Ala Arg Gln Phe Ala Asp 
        115                 120                 125             


Leu Gln Val Pro Gln Glu Val Tyr Val Cys Leu Lys Ala Leu Thr Leu 
    130                 135                 140                 


Tyr Thr Thr Ala Val Ser Arg Leu Gln Asp Tyr Arg Gln Val Gln Arg 
145                 150                 155                 160 


Leu Gln His Glu Ile Asn Glu Ala Leu Ala Glu Ala Cys Ser Ser Thr 
                165                 170                 175     


Phe Gly Phe Ser Pro Gly Asn Ile Ala Arg Leu Met Met Ile Val Ser 
            180                 185                 190         


Gln Val Arg Gln Leu Ser Ser Leu Gly Val Asp His Leu Asn Arg Leu 
        195                 200                 205             


Arg Gly Ala Glu Thr Val Ser Val Glu Gly Leu Leu Arg Glu Ile Val 
    210                 215                 220                 


Asp Glu Pro 
225         


<210>  129
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  129

Leu Ser Pro Glu Glu Leu Ile Ser Arg Ile Met Glu Ala Glu Pro Pro 
1               5                   10                  15      


Glu Ile Tyr Leu Met Lys Asp Met Lys Lys Pro Phe Thr Glu Ala Asn 
            20                  25                  30          


Val Met Met Ser Leu Thr Asn Leu Ala Asp Lys Glu Leu Val His Met 
        35                  40                  45              


Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu Ser Leu Phe 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Cys Trp Leu Glu Val Leu Met Leu 
65                  70                  75                  80  


Gly Leu Met Trp Arg Ser Val Asn His Pro Gly Lys Leu Ile Phe Ser 
                85                  90                  95      


Pro Asp Leu Cys Leu Ser Arg Asp Glu Ser Ser Cys Val Gln Gly Leu 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Ala Thr Ser Arg Phe Arg Glu 
        115                 120                 125             


Leu Lys Leu Gln Arg Glu Glu Tyr Val Cys Leu Lys Ala Met Ile Leu 
    130                 135                 140                 


Leu Asn Ser Asn Met Cys Leu Gly Ser Ser Glu Gly Gly Glu Asp Leu 
145                 150                 155                 160 


Gln Ser Arg Ser Lys Leu Leu Cys Leu Leu Asp Ser Val Thr Asp Ala 
                165                 170                 175     


Leu Val Trp Ala Ile Ser Lys Thr Gly Leu Ser Phe Gln Gln Arg Ser 
            180                 185                 190         


Thr Arg Leu Ala His Leu Leu Met Leu Leu Ser His Ile Arg His Val 
        195                 200                 205             


Ser Asn Lys Gly Met Asp His Leu His Cys Met Lys Met Lys Lys Met 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  130
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  130

Leu Thr Ala Glu Gln Met Val Ser Ala Leu Leu Glu Ala Glu Pro Pro 
1               5                   10                  15      


Ile Val Tyr Ser Glu Tyr Asp Pro Asn Arg Pro Phe Asn Glu Ala Ser 
            20                  25                  30          


Met Met Thr Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ala Ala Arg Phe Arg Met 
        115                 120                 125             


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
145                 150                 155                 160 


Glu Glu Arg Asp Tyr Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
                165                 170                 175     


Leu Ile His Leu Met Ala Lys Ser Gly Leu Ser Leu Gln Gln Gln His 
            180                 185                 190         


Arg Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Asn Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  131
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  131

Leu Thr Ala Glu Gln Leu Ile Ser Ala Leu Met Glu Ala Glu Ala Pro 
1               5                   10                  15      


Ile Val Tyr Ser Glu His Asp Ser Thr Lys Pro Leu Ser Glu Ala Ser 
            20                  25                  30          


Met Met Thr Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Val 
65                  70                  75                  80  


Gly Leu Ile Trp Arg Ser Val Glu His Pro Gly Lys Leu Ser Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Arg Cys Val Glu Gly Leu 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Val Thr Thr Ala Thr Arg Phe Arg Met 
        115                 120                 125             


Met Arg Leu Arg Gly Glu Glu Phe Ile Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Glu Ser Leu 
145                 150                 155                 160 


Glu Asp Thr Asp Leu Ile His Ile Ile Leu Asp Lys Ile Ile Asp Thr 
                165                 170                 175     


Leu Val His Phe Met Ala Lys Ser Gly Leu Ser Leu Gln Gln Gln Gln 
            180                 185                 190         


Arg Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  132
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  132

Gln Arg Leu Lys Ala Leu Ile Asp Ala Leu Asp Val Lys Glu Gly Glu 
1               5                   10                  15      


His Arg Gly Glu Glu Asn His Pro Thr Gly Gln Gln Ala Gly Asn Trp 
            20                  25                  30          


Gln Glu Ile Ser Asn Pro Glu Leu Ile Glu Ser Val Ser Ser Leu Val 
        35                  40                  45              


Asp Arg Glu Leu Thr Gly Ile Ile Cys Trp Gly Lys Lys Ile Pro Gly 
    50                  55                  60                  


Tyr Ser Lys Leu Ser Leu Asn Asp Gln Val Leu Leu Met Glu Ser Thr 
65                  70                  75                  80  


Trp Leu Asp Leu Leu Ile Leu Asp Leu Val Trp Cys Ser Ile Arg His 
                85                  90                  95      


Lys Gly Glu Lys Leu Leu Leu Ser Gly Gly Val Leu Val Asn Arg Asn 
            100                 105                 110         


Thr Ile Ser Asn Arg Arg Asn Asn Ser Ser Gly Asp Asp Met Glu Val 
        115                 120                 125             


Leu Glu Met Cys Asp Gln Ile Leu Ser Ile Ala Thr Lys Phe Tyr Glu 
    130                 135                 140                 


Phe Asp Leu Gln Arg Arg Glu Tyr Leu Cys Leu Lys Ala Ile Thr Leu 
145                 150                 155                 160 


Val His Gly Ser Leu Lys Gly Leu Glu Ser Asp Thr Gln Val Arg Gln 
                165                 170                 175     


Leu Gln Asp Asp Leu Thr Asp Ala Leu Met Asp Val Cys Ser Glu Arg 
            180                 185                 190         


His Ala Leu Gly Ser Arg Arg Pro Ala Lys Met Leu Leu Leu Leu Ser 
        195                 200                 205             


His Leu Arg Gln Val Ser Ala Arg Ala Ser Ser His Leu Gly Ala Val 
    210                 215                 220                 


Arg Asn Gly Leu Lys Val Pro Leu Tyr Asp Ile Leu Leu Asp Ile Leu 
225                 230                 235                 240 


Thr Asp Gln 
            


<210>  133
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  133

Leu Ser Ser Glu Gln Phe Leu Thr Cys Leu Leu Asn Ala Glu Pro Pro 
1               5                   10                  15      


Asn Met Thr Cys His His Asp Val Ser Arg Pro Phe Thr Ala Glu Arg 
            20                  25                  30          


Leu Met Met Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Gly Trp Ala Lys Lys Val Pro Gly Phe Val Gln Ile Ser Leu Arg 
    50                  55                  60                  


Asp Gln Val Leu Leu Leu Glu Ser Ser Trp Leu Glu Val Leu Ile Met 
65                  70                  75                  80  


Gly Leu Ile Trp Arg Ser Met Ser Gln Pro Gly Lys Leu Val Phe Ala 
                85                  90                  95      


Ser Asn Leu Ile Leu Asp Arg Asp Asp Gly Glu Cys Val Glu Gly Ile 
            100                 105                 110         


Phe Glu Ile Phe Asp Ile Leu Leu Asn Ile Val Gln His Phe Arg Glu 
        115                 120                 125             


Leu Gln Val Trp Met Asp Glu Tyr Val Cys Leu Lys Ala Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ala Ser Met Met Val Ala Thr Ser Glu Lys Asp Gly Ser Arg 
145                 150                 155                 160 


Ala Lys Val Gln Gln Leu Val Glu Ala Thr Thr Asp Thr Leu Val Lys 
                165                 170                 175     


Cys Ile Ala Arg Arg Ser Leu Ala Thr Pro Glu Gln Phe Arg Arg Leu 
            180                 185                 190         


Ser His Leu Leu Thr Ile Leu Ser His Ile Arg His Ile Ser Asn Lys 
        195                 200                 205             


Gly Ile Gln His Met Tyr Ser Met Lys Cys Lys Asn Leu Val Pro Phe 
    210                 215                 220                 


Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235 


<210>  134
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Asp Ile Lys Asn Ser Pro Ser Ser Leu Asn Ser Pro Ser Ser Tyr 
1               5                   10                  15      


Asn Cys Ser Gln Ser Ile Leu Pro Leu Glu His Gly Ser Ile Tyr Ile 
            20                  25                  30          


Pro Ser Ser Tyr Val Asp Ser His His Glu Tyr Pro Ala Met Thr Phe 
        35                  40                  45              


Tyr Ser Pro Ala Val Met Asn Tyr Ser Ile Pro Ser Asn Val Thr Asn 
    50                  55                  60                  


Leu Glu Gly Gly Pro Gly Arg Gln Thr Thr Ser Pro Asn Val Leu Trp 
65                  70                  75                  80  


Pro Thr Pro Gly His Leu Ser Pro Leu Val Val His Arg Gln Leu Ser 
                85                  90                  95      


His Leu Tyr Ala Glu Pro Gln Lys Ser Pro Trp Cys Glu Ala Arg Ser 
            100                 105                 110         


Leu Glu His Thr Leu Pro Val Asn Arg Glu Thr Leu Lys Arg Lys Val 
        115                 120                 125             


Ser Gly Asn Arg Cys Ala Ser Pro Val Thr Gly Pro Gly Ser Lys Arg 
    130                 135                 140                 


Asp Ala His Phe Cys Ala Val Cys Ser Asp Tyr Ala Ser Gly Tyr His 
145                 150                 155                 160 


Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe Phe Lys Arg Ser 
                165                 170                 175     


Ile Gln Gly His Asn Asp Tyr Ile Cys Pro Ala Thr Asn Gln Cys Thr 
            180                 185                 190         


Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys Arg Leu Arg Lys 
        195                 200                 205             


Cys Tyr Glu Val Gly Met Val Lys Cys Gly Ser Arg Arg Glu Arg Cys 
    210                 215                 220                 


Gly Tyr Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His 
225                 230                 235                 240 


Cys Ala Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg 
                245                 250                 255     


Glu Leu Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu 
            260                 265                 270         


Leu Glu Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro 
        275                 280                 285             


Phe Thr Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys 
    290                 295                 300                 


Glu Leu Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val 
305                 310                 315                 320 


Glu Leu Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met 
                325                 330                 335     


Glu Val Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly 
            340                 345                 350         


Lys Leu Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys 
        355                 360                 365             


Cys Val Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr 
    370                 375                 380                 


Ser Arg Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val 
385                 390                 395                 400 


Lys Ala Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala 
                405                 410                 415     


Thr Gln Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala 
            420                 425                 430         


Val Thr Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser 
        435                 440                 445             


Gln Gln Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His 
    450                 455                 460                 


Val Arg His Ala Ser Asn Lys Gly Met Glu His Leu Leu Asn Met Lys 
465                 470                 475                 480 


Cys Lys Asn Val Val Pro Val Tyr Asp Leu Leu Leu Glu Met Leu Asn 
                485                 490                 495     


Ala His Val Leu Arg Gly Cys Lys Ser Ser Ile Thr Gly Ser Glu Cys 
            500                 505                 510         


Ser Pro Ala Glu Asp Ser Lys Ser Lys Glu Gly Ser Gln Asn Pro Gln 
        515                 520                 525             


Ser Gln 
    530 


<210>  135
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  135

Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu Leu Glu Ala 
1               5                   10                  15      


Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro Phe Thr Glu 
            20                  25                  30          


Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys Glu Leu Val 
        35                  40                  45              


His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu Ser 
    50                  55                  60                  


Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met Glu Val Leu 
65                  70                  75                  80  


Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly Lys Leu Ile 
                85                  90                  95      


Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys Cys Val Glu 
            100                 105                 110         


Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr Ser Arg Phe 
        115                 120                 125             


Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val Lys Ala Met 
    130                 135                 140                 


Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala Thr Gln Asp 
145                 150                 155                 160 


Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala Val Thr Asp 
                165                 170                 175     


Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser Gln Gln Gln 
            180                 185                 190         


Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His Val Arg His 
        195                 200                 205             


Ala Ser Asn Lys Gly Met Glu His Leu Leu Asn Met Lys Cys Lys Asn 
    210                 215                 220                 


Val Val Pro Val Tyr Asp Leu Leu Leu Glu Met Leu Asn Ala His Val 
225                 230                 235                 240 


Leu Arg Gly 
            


<210>  136
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  136

Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
1               5                   10                  15      


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser 
            20                  25                  30          


Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
        115                 120                 125             


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
145                 150                 155                 160 


Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
                165                 170                 175     


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
            180                 185                 190         


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  137
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  137

Leu Ser Pro Glu Gln Leu Val Leu Thr Leu Leu Glu Ala Glu Pro Pro 
1               5                   10                  15      


His Val Leu Ile Ser Arg Pro Ser Ala Pro Phe Thr Glu Ala Ser Met 
            20                  25                  30          


Met Met Ser Leu Thr Lys Leu Ala Asp Lys Glu Leu Val His Met Ile 
        35                  40                  45              


Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu Ser Leu Phe Asp 
    50                  55                  60                  


Gln Val Arg Leu Leu Glu Ser Cys Trp Met Glu Val Leu Met Met Gly 
65                  70                  75                  80  


Leu Met Trp Arg Ser Ile Asp His Pro Gly Lys Leu Ile Phe Ala Pro 
                85                  90                  95      


Asp Leu Val Leu Asp Arg Asp Glu Gly Lys Cys Val Glu Gly Ile Leu 
            100                 105                 110         


Glu Ile Phe Asp Met Leu Leu Ala Thr Thr Ser Arg Phe Arg Glu Leu 
        115                 120                 125             


Lys Leu Gln His Lys Glu Tyr Leu Cys Val Lys Ala Met Ile Leu Leu 
    130                 135                 140                 


Asn Ser Ser Met Tyr Pro Leu Val Thr Ala Thr Gln Asp Ala Asp Ser 
145                 150                 155                 160 


Ser Arg Lys Leu Ala His Leu Leu Asn Ala Val Thr Asp Ala Leu Val 
                165                 170                 175     


Trp Val Ile Ala Lys Ser Gly Ile Ser Ser Gln Gln Gln Ser Met Arg 
            180                 185                 190         


Leu Ala Asn Leu Leu Met Leu Leu Ser His Val Arg His Ala Ser Asn 
        195                 200                 205             


Lys Gly Met Glu His Leu Leu Asn Met Lys Cys Lys Asn Val Val Pro 
    210                 215                 220                 


Val Tyr Asp Leu Leu Leu Glu Met Leu Asn Ala His 
225                 230                 235     


<210>  138
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  138

Asn Pro Thr Val Pro Leu Ile Ser His Leu Val Asn Ile Glu Pro Asn 
1               5                   10                  15      


Pro Ile Leu Thr Gly Tyr Asn Pro Gln Cys Thr Pro Thr Glu Gly Tyr 
            20                  25                  30          


Leu Met Ala Leu Val Thr Asp Leu Ala Asn Arg Glu Ile Glu Gly Leu 
        35                  40                  45              


Val Asp Trp Ala Ala Arg Leu Pro Gly Tyr Gly Met Leu Pro Met Asp 
    50                  55                  60                  


Asp Gln Val Asn Leu Ile Arg Thr Val Trp Leu Asp Leu Leu Met Leu 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Arg Gly Glu Trp Leu Val Phe 
                85                  90                  95      


Ala Pro Asp Leu Leu Met Asp Arg Ser Leu Cys Arg Leu Ser Gly Met 
            100                 105                 110         


Glu Tyr Ile Cys Thr Pro Met Leu Glu Phe Ala Arg Gln Phe Ala Asp 
        115                 120                 125             


Leu Gln Val Pro Gln Glu Val Tyr Val Cys Leu Lys Ala Leu Thr Leu 
    130                 135                 140                 


Tyr Thr Thr Ala Val Ser Arg Leu Gln Asp Tyr Arg Gln Val Gln Arg 
145                 150                 155                 160 


Leu Gln His Glu Ile Asn Glu Ala Leu Ala Glu Ala Cys Ser Ser Thr 
                165                 170                 175     


Phe Gly Phe Ser Pro Gly Asn Ile Ala Arg Leu Met Met Ile Val Ser 
            180                 185                 190         


Gln Val Arg Gln Leu Ser Ser Leu Gly Val Asp His Leu Asn Arg Leu 
        195                 200                 205             


Arg Gly Ala Glu Thr Val Ser Val Glu Gly Leu Leu Arg Glu Ile Val 
    210                 215                 220                 


Asp Glu Pro 
225         


<210>  139
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  139

Leu Ser Pro Glu Glu Leu Ile Ser Arg Ile Met Glu Ala Glu Pro Pro 
1               5                   10                  15      


Glu Ile Tyr Leu Met Lys Asp Met Lys Lys Pro Phe Thr Glu Ala Asn 
            20                  25                  30          


Val Met Met Ser Leu Thr Asn Leu Ala Asp Lys Glu Leu Val His Met 
        35                  40                  45              


Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu Ser Leu Phe 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Cys Trp Leu Glu Val Leu Met Leu 
65                  70                  75                  80  


Gly Leu Met Trp Arg Ser Val Asn His Pro Gly Lys Leu Ile Phe Ser 
                85                  90                  95      


Pro Asp Leu Cys Leu Ser Arg Asp Glu Ser Ser Cys Val Gln Gly Leu 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Ala Thr Ser Arg Phe Arg Glu 
        115                 120                 125             


Leu Lys Leu Gln Arg Glu Glu Tyr Val Cys Leu Lys Ala Met Ile Leu 
    130                 135                 140                 


Leu Asn Ser Asn Met Cys Leu Gly Ser Ser Glu Gly Gly Glu Asp Leu 
145                 150                 155                 160 


Gln Ser Arg Ser Lys Leu Leu Cys Leu Leu Asp Ser Val Thr Asp Ala 
                165                 170                 175     


Leu Val Trp Ala Ile Ser Lys Thr Gly Leu Ser Phe Gln Gln Arg Ser 
            180                 185                 190         


Thr Arg Leu Ala His Leu Leu Met Leu Leu Ser His Ile Arg His Val 
        195                 200                 205             


Ser Asn Lys Gly Met Asp His Leu His Cys Met Lys Met Lys Lys Met 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  140
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  140

Leu Thr Ala Glu Gln Met Val Ser Ala Leu Leu Glu Ala Glu Pro Pro 
1               5                   10                  15      


Ile Val Tyr Ser Glu Tyr Asp Pro Asn Arg Pro Phe Asn Glu Ala Ser 
            20                  25                  30          


Met Met Thr Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
65                  70                  75                  80  


Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys Leu Leu Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ala Ala Arg Phe Arg Met 
        115                 120                 125             


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
145                 150                 155                 160 


Glu Glu Arg Asp Tyr Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
                165                 170                 175     


Leu Ile His Leu Met Ala Lys Ser Gly Leu Ser Leu Gln Gln Gln His 
            180                 185                 190         


Arg Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Asn Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  141
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  141

Leu Thr Ala Glu Gln Leu Ile Ser Ala Leu Met Glu Ala Glu Ala Pro 
1               5                   10                  15      


Ile Val Tyr Ser Glu His Asp Ser Thr Lys Pro Leu Ser Glu Ala Ser 
            20                  25                  30          


Met Met Thr Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
    50                  55                  60                  


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Val 
65                  70                  75                  80  


Gly Leu Ile Trp Arg Ser Val Glu His Pro Gly Lys Leu Ser Phe Ala 
                85                  90                  95      


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Arg Cys Val Glu Gly Leu 
            100                 105                 110         


Val Glu Ile Phe Asp Met Leu Val Thr Thr Ala Thr Arg Phe Arg Met 
        115                 120                 125             


Met Arg Leu Arg Gly Glu Glu Phe Ile Cys Leu Lys Ser Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Glu Ser Leu 
145                 150                 155                 160 


Glu Asp Thr Asp Leu Ile His Ile Ile Leu Asp Lys Ile Ile Asp Thr 
                165                 170                 175     


Leu Val His Phe Met Ala Lys Ser Gly Leu Ser Leu Gln Gln Gln Gln 
            180                 185                 190         


Arg Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
        195                 200                 205             


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
    210                 215                 220                 


Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235             


<210>  142
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  142

Gln Arg Leu Lys Ala Leu Ile Asp Ala Leu Asp Val Lys Glu Gly Glu 
1               5                   10                  15      


His Arg Gly Glu Glu Asn His Pro Thr Gly Gln Gln Ala Gly Asn Trp 
            20                  25                  30          


Gln Glu Ile Ser Asn Pro Glu Leu Ile Glu Ser Val Ser Ser Leu Val 
        35                  40                  45              


Asp Arg Glu Leu Thr Gly Ile Ile Cys Trp Gly Lys Lys Ile Pro Gly 
    50                  55                  60                  


Tyr Ser Lys Leu Ser Leu Asn Asp Gln Val Leu Leu Met Glu Ser Thr 
65                  70                  75                  80  


Trp Leu Asp Leu Leu Ile Leu Asp Leu Val Trp Cys Ser Ile Arg His 
                85                  90                  95      


Lys Gly Glu Lys Leu Leu Leu Ser Gly Gly Val Leu Val Asn Arg Asn 
            100                 105                 110         


Thr Ile Ser Asn Arg Arg Asn Asn Ser Ser Gly Asp Asp Met Glu Val 
        115                 120                 125             


Leu Glu Met Cys Asp Gln Ile Leu Ser Ile Ala Thr Lys Phe Tyr Glu 
    130                 135                 140                 


Phe Asp Leu Gln Arg Arg Glu Tyr Leu Cys Leu Lys Ala Ile Thr Leu 
145                 150                 155                 160 


Val His Gly Ser Leu Lys Gly Leu Glu Ser Asp Thr Gln Val Arg Gln 
                165                 170                 175     


Leu Gln Asp Asp Leu Thr Asp Ala Leu Met Asp Val Cys Ser Glu Arg 
            180                 185                 190         


His Ala Leu Gly Ser Arg Arg Pro Ala Lys Met Leu Leu Leu Leu Ser 
        195                 200                 205             


His Leu Arg Gln Val Ser Ala Arg Ala Ser Ser His Leu Gly Ala Val 
    210                 215                 220                 


Arg Asn Gly Leu Lys Val Pro Leu Tyr Asp Ile Leu Leu Asp Ile Leu 
225                 230                 235                 240 


Thr Asp Gln 
            


<210>  143
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  143

Leu Ser Ser Glu Gln Phe Leu Thr Cys Leu Leu Asn Ala Glu Pro Pro 
1               5                   10                  15      


Asn Met Thr Cys His His Asp Val Ser Arg Pro Phe Thr Ala Glu Arg 
            20                  25                  30          


Leu Met Met Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
        35                  40                  45              


Ile Gly Trp Ala Lys Lys Val Pro Gly Phe Val Gln Ile Ser Leu Arg 
    50                  55                  60                  


Asp Gln Val Leu Leu Leu Glu Ser Ser Trp Leu Glu Val Leu Ile Met 
65                  70                  75                  80  


Gly Leu Ile Trp Arg Ser Met Ser Gln Pro Gly Lys Leu Val Phe Ala 
                85                  90                  95      


Ser Asn Leu Ile Leu Asp Arg Asp Asp Gly Glu Cys Val Glu Gly Ile 
            100                 105                 110         


Phe Glu Ile Phe Asp Ile Leu Leu Asn Ile Val Gln His Phe Arg Glu 
        115                 120                 125             


Leu Gln Val Trp Met Asp Glu Tyr Val Cys Leu Lys Ala Ile Ile Leu 
    130                 135                 140                 


Leu Asn Ala Ser Met Met Val Ala Thr Ser Glu Lys Asp Gly Ser Arg 
145                 150                 155                 160 


Ala Lys Val Gln Gln Leu Val Glu Ala Thr Thr Asp Thr Leu Val Lys 
                165                 170                 175     


Cys Ile Ala Arg Arg Ser Leu Ala Thr Pro Glu Gln Phe Arg Arg Leu 
            180                 185                 190         


Ser His Leu Leu Thr Ile Leu Ser His Ile Arg His Ile Ser Asn Lys 
        195                 200                 205             


Gly Ile Gln His Met Tyr Ser Met Lys Cys Lys Asn Leu Val Pro Phe 
    210                 215                 220                 


Tyr Asp Leu Leu Leu Glu Met Leu Asp Ala His 
225                 230                 235 


<210>  144
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Val Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser 
1               5                   10                  15      


Ser Val Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile 
            20                  25                  30          


Lys Pro Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr 
        35                  40                  45              


Glu Asp Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp Tyr Lys 
    50                  55                  60                  


Tyr Asp Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro 
65                  70                  75                  80  


Ala Ser Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro 
                85                  90                  95      


His Glu Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys 
            100                 105                 110         


Gly Asp Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly 
        115                 120                 125             


Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp 
    130                 135                 140                 


Arg Cys Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys 
145                 150                 155                 160 


Gln Tyr Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn 
                165                 170                 175     


Ala Ile Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu 
            180                 185                 190         


Ala Glu Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp 
        195                 200                 205             


Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe 
    210                 215                 220                 


Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr 
225                 230                 235                 240 


Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly 
                245                 250                 255     


Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser 
            260                 265                 270         


Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val 
        275                 280                 285             


Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe 
    290                 295                 300                 


Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val 
305                 310                 315                 320 


His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly 
                325                 330                 335     


Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys 
            340                 345                 350         


Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe 
        355                 360                 365             


Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile 
    370                 375                 380                 


Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn 
385                 390                 395                 400 


Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu 
                405                 410                 415     


Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys 
            420                 425                 430         


Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val 
        435                 440                 445             


Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His 
    450                 455                 460                 


Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
465                 470                 475 


<210>  145
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  145

Ser His Asn Ala Ile Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu 
1               5                   10                  15      


Lys Leu Leu Ala Glu Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu 
            20                  25                  30          


Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile 
        35                  40                  45              


Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly 
    50                  55                  60                  


Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu 
65                  70                  75                  80  


Met Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln 
                85                  90                  95      


Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe 
            100                 105                 110         


Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile 
        115                 120                 125             


Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys 
    130                 135                 140                 


Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn 
145                 150                 155                 160 


Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu 
                165                 170                 175     


Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys 
            180                 185                 190         


Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp 
        195                 200                 205             


Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly 
    210                 215                 220                 


Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln 
225                 230                 235                 240 


Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu 
                245                 250                 255     


Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr 
            260                 265                 270         


Glu His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met 
        275                 280                 285             


Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
    290                 295                 300         


<210>  146
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  146

Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu Ile Ser 
1               5                   10                  15      


Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg Ala Leu 
            20                  25                  30          


Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys 
        35                  40                  45              


Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro 
    50                  55                  60                  


Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile 
65                  70                  75                  80  


Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala 
                85                  90                  95      


Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln 
            100                 105                 110         


Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp 
        115                 120                 125             


Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile 
    130                 135                 140                 


Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser 
145                 150                 155                 160 


Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys 
                165                 170                 175     


Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe 
            180                 185                 190         


Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val 
        195                 200                 205             


Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile 
    210                 215                 220                 


Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys 
225                 230                 235                 240 


Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys 
                245                 250                 255     


Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu Leu Gln 
            260                 265                 270         


Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln 
        275                 280                 285             


Glu Ile Tyr Lys Asp Leu Tyr 
    290                 295 


<210>  147
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  147

Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr 
1               5                   10                  15      


Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr 
            20                  25                  30          


Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser 
        35                  40                  45              


Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu 
    50                  55                  60                  


Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln 
65                  70                  75                  80  


Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser 
                85                  90                  95      


Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu 
            100                 105                 110         


Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met 
        115                 120                 125             


Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro 
145                 150                 155                 160 


Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser 
                165                 170                 175     


Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro 
            180                 185                 190         


Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu 
        195                 200                 205             


Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln 
    210                 215                 220                 


Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val 
225                 230                 235                 240 


Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp 
                245                 250                 255     


Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            260                 265                 270     


<210>  148
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  148

Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys 
1               5                   10                  15      


Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys 
            20                  25                  30          


Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met 
        35                  40                  45              


Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu 
    50                  55                  60                  


Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg 
65                  70                  75                  80  


Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro 
                85                  90                  95      


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
            100                 105                 110         


Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys 
        115                 120                 125             


Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe 
    130                 135                 140                 


Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe 
145                 150                 155                 160 


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
                165                 170                 175     


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
            180                 185                 190         


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
        195                 200                 205             


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
    210                 215                 220                 


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
225                 230                 235                 240 


His Val Gln Leu Leu Gln Val 
                245         


<210>  149
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  149

Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys 
1               5                   10                  15      


Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys 
            20                  25                  30          


Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met 
        35                  40                  45              


Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu 
    50                  55                  60                  


Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg 
65                  70                  75                  80  


Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro 
                85                  90                  95      


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
            100                 105                 110         


Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys 
        115                 120                 125             


Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe 
    130                 135                 140                 


Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe 
145                 150                 155                 160 


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
                165                 170                 175     


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
            180                 185                 190         


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
        195                 200                 205             


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
    210                 215                 220                 


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
225                 230                 235                 240 


His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser 
                245                 250                 255     


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu 
            260                 265             


<210>  150
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  150

Ala Asp Leu Lys Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys 
1               5                   10                  15      


Asn Phe Asn Met Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys 
            20                  25                  30          


Ala Ser His Thr Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp 
        35                  40                  45              


Gln Ala Glu Lys Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro 
    50                  55                  60                  


Pro Tyr Lys Glu Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr 
65                  70                  75                  80  


Thr Val Glu Thr Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro 
                85                  90                  95      


Ser Phe Ser Ser Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
            100                 105                 110         


Gly Val His Glu Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys 
        115                 120                 125             


Asp Gly Leu Leu Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe 
    130                 135                 140                 


Leu Arg Ser Leu Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe 
145                 150                 155                 160 


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
                165                 170                 175     


Ala Leu Phe Ile Ala Ala Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu 
            180                 185                 190         


Met Asn Val Pro Arg Val Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala 
        195                 200                 205             


Leu Glu Phe His Leu Gln Ala Asn His Pro Asp Ala Gln Tyr Leu Phe 
    210                 215                 220                 


Pro Lys Leu Leu Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu 
225                 230                 235                 240 


His Ala Gln Met Met Gln Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser 
                245                 250                 255     


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Met 
            260                 265             


<210>  151
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  151

Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys 
1               5                   10                  15      


Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys 
            20                  25                  30          


Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Arg 
        35                  40                  45              


Met Gly Glu Asp Gln Ile Lys Cys Lys His Ala Ser Pro Leu Gln Glu 
    50                  55                  60                  


Gln Asn Lys Glu Val Ala Ile Arg Ile Phe Gln Arg Cys Gln Phe Arg 
65                  70                  75                  80  


Ser Val Glu Ala Val Gln Glu Ile Thr Glu Phe Ala Lys Asn Ile Pro 
                85                  90                  95      


Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr 
            100                 105                 110         


Gly Val His Glu Ile Ile Tyr Thr Leu Leu Ala Ser Leu Met Asn Lys 
        115                 120                 125             


Asp Gly Val Leu Ile Ser Asp Gly Gln Gly Phe Met Thr Arg Glu Phe 
    130                 135                 140                 


Leu Lys Ser Leu Arg Lys Pro Phe Cys Asp Phe Met Glu Pro Lys Phe 
145                 150                 155                 160 


Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu 
                165                 170                 175     


Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu 
            180                 185                 190         


Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala 
        195                 200                 205             


Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe 
    210                 215                 220                 


Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu 
225                 230                 235                 240 


His Val Gln Leu Leu Gln Ile Ile Lys Lys Thr Glu Thr Asp Met Ser 
                245                 250                 255     


Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu 
            260                 265             


<210>  152
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  152

Ala Asp Leu Arg Ala Leu Ala Arg His Leu Tyr Glu Ala Tyr Leu Lys 
1               5                   10                  15      


Tyr Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Ser Gly Lys 
            20                  25                  30          


Thr Gly Asp Asn Ala Pro Phe Val Ile His Asp Ile Lys Ser Leu Met 
        35                  40                  45              


Glu Gly Glu Gln Phe Ile Asn Cys Arg Gln Met Pro Ile Gln Glu Gln 
    50                  55                  60                  


Gln Gln Ala Ser Val Leu Thr Ala Thr His Gly Gly Leu Thr Glu His 
65                  70                  75                  80  


His Met Gly Ser Asp Tyr Gly Val Trp Gly Thr Thr Ser Ile Ser Gly 
                85                  90                  95      


Gln Glu Pro Gln Asn Ala Leu Glu Leu Arg Phe Phe Gln Ser Cys Gln 
            100                 105                 110         


Ser Arg Ser Ala Glu Ala Val Arg Glu Val Thr Glu Phe Ala Lys Ser 
        115                 120                 125             


Ile Pro Gly Phe Thr Asp Leu Asp Leu Asn Asp Gln Val Thr Leu Leu 
    130                 135                 140                 


Lys Tyr Gly Val Ile Glu Val Leu Ile Ile Met Met Ser Pro Leu Met 
145                 150                 155                 160 


Asn Lys Asp Gly Thr Leu Ile Ser Tyr Gly Gln Ile Phe Met Thr Arg 
                165                 170                 175     


Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys Gln Met Met Glu Pro 
            180                 185                 190         


Lys Phe Glu Phe Ser Val Lys Phe Asn Thr Leu Glu Leu Asp Asp Ser 
        195                 200                 205             


Asp Met Ala Leu Phe Leu Val Val Ile Ile Leu Ser Gly Asp Arg Pro 
    210                 215                 220                 


Gly Leu Leu Asn Val Lys Pro Ile Glu Gln Leu Gln Glu Thr Val Leu 
225                 230                 235                 240 


His Ser Leu Glu Leu Gln Leu Lys Leu Asn His Pro Asp Ser Leu Gln 
                245                 250                 255     


Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val 
            260                 265                 270         


Thr Asp His Val His Leu Ile Gln Leu Leu Lys Lys Thr Glu Val Asp 
        275                 280                 285             


Met Cys Leu His Pro Leu Leu Gln Glu Ile Met Lys Asp Leu 
    290                 295                 300         


<210>  153
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  153

Thr Lys Leu Val Ser Pro Cys Asp Glu Met Leu Thr Pro Asp Leu Lys 
1               5                   10                  15      


Ala Arg Leu Leu Phe Ala Ser Gln Val Phe Lys Lys Asn Ile Gly Lys 
            20                  25                  30          


Asp Lys Pro Thr Ile Tyr Lys Asn Val Ile Gly Ser Lys Ile Val Gln 
        35                  40                  45              


Ile Leu Tyr Ser Asp Phe Gln Ala Arg Val Val Asn Gly Ile Cys Glu 
    50                  55                  60                  


Leu Thr Glu Phe Ala Lys Arg Leu Pro Asn Phe His Asp Ile Ser Leu 
65                  70                  75                  80  


Gln Asp Gln Val Ile Leu Leu Lys Tyr Gly Ser Tyr Glu Thr Met Phe 
                85                  90                  95      


Val Leu Phe Ser Arg Leu Ile Tyr Gly Glu Gly Met Ile Leu Pro Lys 
            100                 105                 110         


Ser Asn Ile Tyr Val Thr Phe Asn Phe Val Tyr Gln Leu Gly Val Ala 
        115                 120                 125             


Gly Asp Ile Met Lys Ser Lys Phe Leu Phe Ala Lys Lys Met Leu Ala 
    130                 135                 140                 


Leu Glu Leu Thr Asp Asp Glu Met Ala Leu Phe Val Ala Met Ile Ile 
145                 150                 155                 160 


Leu Cys Pro Asp Arg Pro Glu Ile Asn Asp Arg Lys Leu Val Glu Arg 
                165                 170                 175     


Ile Gln Glu Lys Val Leu Phe Ala Leu Glu Tyr Gln Leu Ser Ile Ser 
            180                 185                 190         


His Pro His Lys Pro Arg Leu Phe Ala His Leu Leu Leu Lys Met Ala 
        195                 200                 205             


Glu Leu Arg Glu Leu Val Ser Lys His Val Val Met Val Gln Lys Leu 
    210                 215                 220                 


Ala Asp Ala Lys Asp Phe Val Pro Pro Leu Leu Cys Glu Ile Met Gln 
225                 230                 235                 240 


Asp Met 
        


<210>  154
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  154

Ser Asp Leu Asp Val Leu Ser Gln Leu Ile His Ser Ser Tyr Met Asn 
1               5                   10                  15      


Thr Phe Thr Met Thr Lys Lys Arg Ala Arg Asp Ile Leu Thr Gly Arg 
            20                  25                  30          


Asn Ser Ile Ser Pro Phe Val Ile His Asp Met Asp Thr Leu Trp Gln 
        35                  40                  45              


Ala Glu Gln Gly Thr Val Trp Glu Gln Leu Pro Thr Gln Asn Leu Thr 
    50                  55                  60                  


Gly Thr Glu Ile Gly Val His Val Phe Tyr Arg Cys Gln Cys Thr Ser 
65                  70                  75                  80  


Val Glu Thr Val Arg Ala Leu Thr Asp Phe Ala Lys Arg Ile Pro Gly 
                85                  90                  95      


Phe Gly Thr Leu Tyr Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly 
            100                 105                 110         


Val His Glu Ala Ile Phe Cys Met Leu Ala Ser Leu Met Asn Lys Asp 
        115                 120                 125             


Gly Leu Leu Val Ala Gly Gly Arg Gly Phe Val Thr Arg Glu Phe Leu 
    130                 135                 140                 


Arg Ser Leu Arg Gln Pro Phe Cys His Ile Met Glu Pro Lys Phe His 
145                 150                 155                 160 


Phe Ala Ser Lys Phe Asn Ala Leu Glu Leu Asn Asp Ser Asp Leu Ala 
                165                 170                 175     


Leu Phe Val Ala Ser Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Ile 
            180                 185                 190         


Asn Pro Ser Gln Val Glu Asp Ile Gln Glu Gly Ile Leu Gly Ala Leu 
        195                 200                 205             


Arg Arg His Leu Lys Ala Ser His Thr Asp Ala Pro Phe Leu Phe Pro 
    210                 215                 220                 


Lys Leu Leu His Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His 
225                 230                 235                 240 


Ala Glu Leu Val Gln Ser Ile Lys Arg Thr Glu Ser Ser Ala Ala Leu 
                245                 250                 255     


His Pro Leu Leu Gln Glu Ile Tyr Arg Asp Met 
            260                 265         


<210>  155
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  155

Arg Ile His Ser Ile Tyr Ile Asn Met Trp Met Gly Gln Phe Ile Ser 
1               5                   10                  15      


Met Pro Val Gly Ser Arg Ala Thr Arg Ser Lys Glu Pro Asn Gly Lys 
            20                  25                  30          


Thr Glu Asp His Lys Ser Met Lys Glu Leu Thr Glu Lys Glu Ala Leu 
        35                  40                  45              


Thr Lys Phe Cys Arg Gly Ala Leu Leu Ala Ile Ile Glu Ser Leu Ala 
    50                  55                  60                  


Lys Phe Ala Lys Lys Leu Gln Glu Phe Lys Asn Leu Asp Leu Asn Asp 
65                  70                  75                  80  


Gln Val Cys Leu Leu Lys His Ala Ala Phe Glu Val Ala Leu Ile Ala 
                85                  90                  95      


Thr Ser Ser Arg Tyr Ala Ser Glu Gly Leu Trp Phe Pro Thr Asp Gly 
            100                 105                 110         


Val Tyr Phe Thr Lys Lys Met Leu Glu Gln Leu Glu Ile Ser Phe Phe 
        115                 120                 125             


Asp Gly Lys Phe Lys Phe Phe Glu Lys Met Lys Lys Leu Asn Leu Thr 
    130                 135                 140                 


Glu Arg Glu Leu Ala Leu Phe Cys Val Leu Ser Leu Thr Ser Pro Asp 
145                 150                 155                 160 


Arg Asp Glu Leu Ile Glu Arg Asp Glu Val Glu Lys Phe Gln Glu Gln 
                165                 170                 175     


Val Leu Glu Ala Ile Gln Ile Glu Leu Arg Thr Asn His Ser Asn His 
            180                 185                 190         


Arg Met Leu Leu Pro Arg Leu Leu Ser Leu Leu Val Asp Leu Arg Gln 
        195                 200                 205             


Leu Val Leu Asp His Ile Lys Gln Val Gln Gln Leu Met Leu Met Asp 
    210                 215                 220                 


Asp Pro Ser Tyr Ser Gly Pro Pro Pro Leu Ile Lys Glu Ile Phe Gly 
225                 230                 235                 240 


Leu Tyr 
        


<210>  156
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  156

Val Asp Ser Ile Ala Gln Gln Phe Asn Asp Ile Val Cys Ala Met Thr 
1               5                   10                  15      


Gln Glu Asp Leu Glu Lys Phe Trp Lys Arg Cys Ser Arg Pro Phe Thr 
            20                  25                  30          


Ala His Met Pro Ser Gly Thr Tyr Val Ile Glu Gly Met Gln Leu Asn 
        35                  40                  45              


Lys Asp Gly Pro Pro Gln Glu Ile Thr Ser Arg Ala Glu Met Ala Gln 
    50                  55                  60                  


Gln Cys Phe Val Ser Met Glu Val Thr Ile Glu Lys Phe Ala Thr Phe 
65                  70                  75                  80  


Ala Lys Gln Leu Pro Glu Phe Arg Arg Leu Ser Ser Ser Asp Gln Leu 
                85                  90                  95      


Thr Leu Phe Lys Gly Ala Ala Leu Glu Val Cys Ala Thr Leu Ser Ala 
            100                 105                 110         


Ser Arg Tyr Tyr His Gly Val Tyr Arg Phe Pro Glu Ile Asn Thr Tyr 
        115                 120                 125             


Ile Arg Arg Asp Val Ala Glu Asn Ser Pro Phe Gly Lys Val Thr Thr 
    130                 135                 140                 


Tyr Thr Thr Glu Met Met Phe Tyr Glu Met Phe Asn Glu Leu Gly Leu 
145                 150                 155                 160 


Thr Asp Lys Glu Lys Ala Val Phe Cys Thr Phe Leu Leu Tyr Ser Pro 
                165                 170                 175     


Asp Arg Glu Gly Leu Val Asp Arg Glu Val Val Glu Arg His Gln Glu 
            180                 185                 190         


His Leu Ala Gln Ile Leu Tyr Leu Glu Val Lys Lys Asn His Pro Asp 
        195                 200                 205             


Arg Ser Asn Leu Tyr Ala Lys Leu Met Asp Val Ala Val Ala Leu Arg 
    210                 215                 220                 


Thr Leu Val Pro Asp His Leu Ala Arg Leu Glu Gln Ile Lys Met Arg 
225                 230                 235                 240 


Cys Asn Gly His Leu Pro Ala Glu Pro Ser Pro Leu Leu Asn Glu Val 
                245                 250                 255     


Tyr Gly Ser Ile 
            260 


<210>  157
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  157

Ser Asp Leu Arg Ser Leu Ala Arg Leu Val Gln Glu Ala Tyr Leu Arg 
1               5                   10                  15      


Ile Phe Pro Leu Ser Lys Ala Lys Ala Gln Ala Ile Leu Ala Gly Lys 
            20                  25                  30          


Val Gln Asn Asn Ala Val Val Ile His Asp His Glu Ser Leu Ala Gln 
        35                  40                  45              


Ala Glu Asp Thr Ile Leu Gln Lys Ser Gly Tyr Gly Thr Ile His Asn 
    50                  55                  60                  


His Gly Ser Ile Gly Val Asn Ile Ala Ser Val Gly Gly Gly Cys Gly 
65                  70                  75                  80  


Gly Ala Arg Gly Gly Thr Ile Cys Asp Gly Arg Gly Gly Pro Cys Asp 
                85                  90                  95      


Ser Thr Thr Arg Gly Arg Val Leu Gly Thr Asp Cys Val Phe Ile Thr 
            100                 105                 110         


Ala Asn Ser Val Thr Asp Thr Glu Leu Ala Ala Asp Ala Glu Gly Asn 
        115                 120                 125             


Arg Ser Ser Asp Gln Glu Val Thr Pro Pro Arg Gly Ala Ala Glu Ile 
    130                 135                 140                 


Arg Ile Phe Asn Arg Cys His Tyr Arg Leu Val Glu Ala Val Arg Glu 
145                 150                 155                 160 


Val Thr Glu Phe Ala Lys Ser Ile Pro Gly Phe Met Ile Leu Asp Leu 
                165                 170                 175     


Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Val Ile Phe 
            180                 185                 190         


Ala Met Leu Ala Ala Gln Ile Asn Lys Asp Gly Leu Leu Ile Ala Tyr 
        195                 200                 205             


Gly Ser Ala Phe Ile Thr Arg Glu Phe Leu Arg Ser Leu Arg Ser Pro 
    210                 215                 220                 


Phe Cys His Ile Met Glu Pro Lys Phe Glu Phe Ser Ile Arg Phe Asn 
225                 230                 235                 240 


Ala Leu Ser Leu Asp Gly Thr Asp Leu Ala Leu Tyr Met Ala Ala Ile 
                245                 250                 255     


Ile Leu Cys Gly Asp Arg Pro Gly Leu Ile Asn Val Asn Pro Val Glu 
            260                 265                 270         


Arg Ile Gln Asp Arg Ile Leu Gln Ala Leu Asp Leu Gln Leu Arg Lys 
        275                 280                 285             


Thr His Pro Glu Ser Pro Phe Leu Phe Pro Lys Leu Leu Gln Lys Leu 
    290                 295                 300                 


Ser Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Met Val His Asn 
305                 310                 315                 320 


Ile Arg Lys Thr Glu Ala Asp Thr Ala Leu Pro Pro Leu Leu Gln Glu 
                325                 330                 335     


Ile Phe Lys Asp Met 
            340     


<210>  158
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Arg Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys 
    450                 455                 460                 


Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg 
465                 470                 475                 480 


Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys 
                485                 490                 495     


Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr 
            500                 505                 510         


Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln 
        515                 520                 525             


Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val 
    530                 535                 540                 


Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile 
545                 550                 555                 560 


Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val 
                565                 570                 575     


Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp 
            580                 585                 590         


Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala 
        595                 600                 605             


Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe 
    610                 615                 620                 


Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met 
625                 630                 635                 640 


Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg 
                645                 650                 655     


Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu 
            660                 665                 670         


Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp 
        675                 680                 685             


Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys 
    690                 695                 700                 


Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr 
705                 710                 715                 720 


Lys Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr 
                725                 730                 735     


Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu 
            740                 745                 750         


Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly 
        755                 760                 765             


Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775             


<210>  159
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  159

Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp Gln 
            100                 105                 110         


Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val 
        115                 120                 125             


Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln 
        195                 200                 205             


Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala 
    210                 215                 220                 


Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  160
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  160

Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Ser Leu Met Ala Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Asp Met Tyr Asp Gln 
            100                 105                 110         


Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val 
        115                 120                 125             


Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln 
        195                 200                 205             


Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala 
    210                 215                 220                 


Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  161
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  161

Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ser 
1               5                   10                  15      


Gly Tyr Asp Ser Thr Leu Pro Asp Ser Ser Trp Arg Ile Met Ser Thr 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Val Ala Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys Gln Ser Asn Gly Asn Leu Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Ile Asn Glu Gln Arg Met Asn Leu Pro Cys Met Tyr Glu Gln 
            100                 105                 110         


Cys Lys His Met Leu Met Val Ala Arg Glu Leu Ser Arg Leu Gln Val 
        115                 120                 125             


Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Ile Pro Lys Glu Gly Leu Lys Ser Gln Thr Leu Phe Glu Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Asp Val Val Glu Asn Leu Leu Ser Phe Cys Phe Gln 
        195                 200                 205             


Thr Phe Leu Asp Lys Ser Met Ser Ile Glu Phe Pro Glu Met Leu Ala 
    210                 215                 220                 


Glu Ile Ile Ser Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  162
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  162

Thr Leu Ile Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ser 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Ile Pro Asp Thr Thr Arg Arg Leu Met Ser Ser 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Val Ser Ala Val Arg Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Val Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Lys Gln Thr Asn Gly Ser Ile Leu Tyr Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Ile Thr Glu Asp Arg Met His Leu Pro Phe Met Gln Glu Arg 
            100                 105                 110         


Cys Gln Glu Met Leu Lys Ile Ala Gly Glu Met Ser Ser Leu Gln Ile 
        115                 120                 125             


Ser Tyr Asp Glu Tyr Leu Cys Met Lys Val Leu Leu Leu Met Cys Thr 
    130                 135                 140                 


Ile Pro Lys Glu Gly Leu Lys Ser His Ala Leu Phe Glu Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Glu Val Ala Glu Asn Leu Leu Ala Phe Cys Phe Leu 
        195                 200                 205             


Ser Phe Leu Asp Lys Ser Met Ser Ile Glu Phe Pro Asp Met Leu Ser 
    210                 215                 220                 


Glu Ile Ile Ser Asn Gln Ile Pro Lys Tyr Ser Ser Gly Asn Leu Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  163
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  163

Thr Met Leu Ser Val Leu Lys Ala Ile Glu Pro Glu Thr Ile Tyr Ser 
1               5                   10                  15      


Gly Tyr Asp Ser Thr Leu Pro Asp Thr Ser Ser Arg Leu Met Ser Thr 
            20                  25                  30          


Leu Asn Arg Leu Gly Gly Gln Gln Val Val Ser Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ser Leu Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Ile 
    50                  55                  60                  


Leu Leu Gln Cys Ser Trp Leu Phe Leu Met Ser Phe Ser Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Gln Gln Cys Asn Gly Ser Met Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Val Ile Asn Glu Glu Arg Met Arg Leu Pro Phe Met Asn Asp Gln 
            100                 105                 110         


Cys Glu Lys Met Leu Arg Ile Cys Arg Glu Phe Val Arg Leu Gln Leu 
        115                 120                 125             


Ser His Glu Glu Tyr Leu Cys Met Lys Val Leu Leu Leu Leu Ser Thr 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Ala Val Phe Asp Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Glu 
                165                 170                 175     


Asn Pro Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met Gln Glu Met Val Glu Gly Leu Ile Lys Phe Cys Phe Tyr 
        195                 200                 205             


Thr Phe Val Asn Lys Thr Leu Ser Val Glu Phe Pro Glu Met Leu Val 
    210                 215                 220                 


Glu Ile Ile Thr Asn Gln Ile Pro Lys Phe Gln Glu Gly Gly Ile Lys 
225                 230                 235                 240 


Ala Leu Leu Phe His Gln Lys 
                245         


<210>  164
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  164

Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Tyr Leu Met Ala Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Gly Met Tyr Asp Gln 
            100                 105                 110         


Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val 
        115                 120                 125             


Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln 
        195                 200                 205             


Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala 
    210                 215                 220                 


Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  165
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  165

Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Ser Leu Met Ala Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp Gln 
            100                 105                 110         


Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val 
        115                 120                 125             


Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln 
        195                 200                 205             


Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala 
    210                 215                 220                 


Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  166
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  166

Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu Tyr Ala 
1               5                   10                  15      


Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met Thr Thr 
            20                  25                  30          


Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys Trp Ala 
        35                  40                  45              


Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln Met Thr 
    50                  55                  60                  


Leu Leu Gln Tyr Ser Trp Met Ser Leu Met Ala Phe Ala Leu Gly Trp 
65                  70                  75                  80  


Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala Pro Asp 
                85                  90                  95      


Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr Asp Gln 
            100                 105                 110         


Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu Gln Val 
        115                 120                 125             


Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu Ser Ser 
    130                 135                 140                 


Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu Ile Arg 
145                 150                 155                 160 


Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg Glu Gly 
                165                 170                 175     


Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys Leu Leu 
            180                 185                 190         


Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys Phe Gln 
        195                 200                 205             


Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met Leu Ala 
    210                 215                 220                 


Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn Ile Lys 
225                 230                 235                 240 


Lys Leu Leu Phe His Gln Lys 
                245         


<210>  167
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Glu Ala Met Ala Ala Ser Thr Ser Leu Pro Asp Pro Gly Asp Phe 
1               5                   10                  15      


Asp Arg Asn Val Pro Arg Ile Cys Gly Val Cys Gly Asp Arg Ala Thr 
            20                  25                  30          


Gly Phe His Phe Asn Ala Met Thr Cys Glu Gly Cys Lys Gly Phe Phe 
        35                  40                  45              


Arg Arg Ser Met Lys Arg Lys Ala Leu Phe Thr Cys Pro Phe Asn Gly 
    50                  55                  60                  


Asp Cys Arg Ile Thr Lys Asp Asn Arg Arg His Cys Gln Ala Cys Arg 
65                  70                  75                  80  


Leu Lys Arg Cys Val Asp Ile Gly Met Met Lys Glu Phe Ile Leu Thr 
                85                  90                  95      


Asp Glu Glu Val Gln Arg Lys Arg Glu Met Ile Leu Lys Arg Lys Glu 
            100                 105                 110         


Glu Glu Ala Leu Lys Asp Ser Leu Arg Pro Lys Leu Ser Glu Glu Gln 
        115                 120                 125             


Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His His Lys Thr Tyr Asp 
    130                 135                 140                 


Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro Pro Val Arg Val Asn 
145                 150                 155                 160 


Asp Gly Gly Gly Ser His Pro Ser Arg Pro Asn Ser Arg His Thr Pro 
                165                 170                 175     


Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys Ser Asp His Cys Ile Thr 
            180                 185                 190         


Ser Ser Asp Met Met Asp Ser Ser Ser Phe Ser Asn Leu Asp Leu Ser 
        195                 200                 205             


Glu Glu Asp Ser Asp Asp Pro Ser Val Thr Leu Glu Leu Ser Gln Leu 
    210                 215                 220                 


Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys 
225                 230                 235                 240 


Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr Ser 
                245                 250                 255     


Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val Ile Met 
            260                 265                 270         


Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp Thr Cys 
        275                 280                 285             


Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys Ala Gly 
    290                 295                 300                 


His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val Gly Leu 
305                 310                 315                 320 


Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile 
                325                 330                 335     


Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala Leu Ile 
            340                 345                 350         


Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr Ile Arg 
        355                 360                 365             


Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys Met Ile 
    370                 375                 380                 


Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln 
385                 390                 395                 400 


Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu Thr Pro 
                405                 410                 415     


Leu Val Leu Glu Val Phe Gly Asn Glu Ile Ser 
            420                 425         


<210>  168
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  168

Glu Leu Ser Glu Glu Gln Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala 
1               5                   10                  15      


His His Lys Thr Tyr Asp Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg 
            20                  25                  30          


Pro Pro Val Arg Val Asn Asp Gly Gly Gly Ser His Pro Ser Arg Pro 
        35                  40                  45              


Asn Ser Arg His Thr Pro Ser Phe Ser Gly Asp Ser Ser Ser Ser Cys 
    50                  55                  60                  


Ser Asp His Cys Ile Thr Ser Ser Asp Met Met Asp Ser Ser Ser Phe 
65                  70                  75                  80  


Ser Asn Leu Asp Leu Ser Glu Glu Asp Ser Asp Asp Pro Ser Val Thr 
                85                  90                  95      


Leu Glu Leu Ser Gln Leu Ser Met Leu Pro His Leu Ala Asp Leu Val 
            100                 105                 110         


Ser Tyr Ser Ile Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly 
        115                 120                 125             


Phe Arg Asp Leu Thr Ser Glu Asp Gln Ile Val Leu Leu Lys Ser Ser 
    130                 135                 140                 


Ala Ile Glu Val Ile Met Leu Arg Ser Asn Glu Ser Phe Thr Met Asp 
145                 150                 155                 160 


Asp Met Ser Trp Thr Cys Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser 
                165                 170                 175     


Asp Val Thr Lys Ala Gly His Ser Leu Glu Leu Ile Glu Pro Leu Ile 
            180                 185                 190         


Lys Phe Gln Val Gly Leu Lys Lys Leu Asn Leu His Glu Glu Glu His 
        195                 200                 205             


Val Leu Leu Met Ala Ile Cys Ile Val Ser Pro Asp Arg Pro Gly Val 
    210                 215                 220                 


Gln Asp Ala Ala Leu Ile Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr 
225                 230                 235                 240 


Leu Gln Thr Tyr Ile Arg Cys Arg His Pro Pro Pro Gly Ser His Leu 
                245                 250                 255     


Leu Tyr Ala Lys Met Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn 
            260                 265                 270         


Glu Glu His Ser Lys Gln Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys 
        275                 280                 285             


Ser Met Lys Leu Thr Pro Leu Val Leu Glu Val Phe Gly Asn Glu Ile 
    290                 295                 300                 


Ser 
305 


<210>  169
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  169

Leu Ser Asp Glu Gln Met Gln Ile Ile Asn Ser Leu Val Glu Ala His 
1               5                   10                  15      


His Lys Thr Tyr Asp Asp Ser Tyr Ser Asp Phe Val Arg Phe Arg Pro 
            20                  25                  30          


Pro Val Arg Glu Gly Pro Val Thr Arg Ser Ala Ser Arg Ala Ala Ser 
        35                  40                  45              


Leu His Ser Leu Ser Asp Ala Ser Ser Asp Ser Phe Asn His Ser Pro 
    50                  55                  60                  


Glu Ser Val Asp Thr Lys Leu Asn Phe Ser Asn Leu Leu Met Met Tyr 
65                  70                  75                  80  


Gln Asp Ser Gly Ser Pro Asp Ser Ser Glu Glu Asp Gln Gln Ser Arg 
                85                  90                  95      


Leu Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile Gln 
            100                 105                 110         


Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Thr 
        115                 120                 125             


Ala Glu Asp Gln Ile Ala Leu Leu Lys Ser Ser Ala Ile Glu Ile Ile 
    130                 135                 140                 


Met Leu Arg Ser Asn Gln Ser Phe Ser Leu Glu Asp Met Ser Trp Ser 
145                 150                 155                 160 


Cys Gly Gly Pro Asp Phe Lys Tyr Cys Ile Asn Asp Val Thr Lys Ala 
                165                 170                 175     


Gly His Thr Leu Glu Leu Leu Glu Pro Leu Val Lys Phe Gln Val Gly 
            180                 185                 190         


Leu Lys Lys Leu Lys Leu His Glu Glu Glu His Val Leu Leu Met Ala 
        195                 200                 205             


Ile Cys Leu Leu Ser Pro Asp Arg Pro Gly Val Gln Asp His Val Arg 
    210                 215                 220                 


Ile Glu Ala Leu Gln Asp Arg Leu Cys Asp Val Leu Gln Ala Tyr Ile 
225                 230                 235                 240 


Arg Ile Gln His Pro Gly Gly Arg Leu Leu Tyr Ala Lys Met Ile Gln 
                245                 250                 255     


Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln Tyr 
            260                 265                 270         


Arg Ser Leu Ser Phe Gln Pro Glu His Ser Met Gln Leu Thr Pro Leu 
        275                 280                 285             


Val Leu Glu Val Phe Gly Ser Glu Val 
    290                 295         


<210>  170
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  170

Leu Ser Glu Glu Gln Gln Arg Ile Ile Ala Ile Leu Leu Asp Ala His 
1               5                   10                  15      


His Lys Thr Tyr Asp Pro Thr Tyr Ser Asp Phe Cys Gln Phe Arg Pro 
            20                  25                  30          


Pro Val Arg Val Asn Asp Gly Gly Gly Ser Val Thr Leu Glu Leu Ser 
        35                  40                  45              


Gln Leu Ser Met Leu Pro His Leu Ala Asp Leu Val Ser Tyr Ser Ile 
    50                  55                  60                  


Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu 
65                  70                  75                  80  


Thr Ser Glu Asp Gln Ile Val Leu Leu Lys Ser Ser Ala Ile Glu Val 
                85                  90                  95      


Ile Met Leu Arg Ser Asn Glu Ser Phe Thr Met Asp Asp Met Ser Trp 
            100                 105                 110         


Thr Cys Gly Asn Gln Asp Tyr Lys Tyr Arg Val Ser Asp Val Thr Lys 
        115                 120                 125             


Ala Gly His Ser Leu Glu Leu Ile Glu Pro Leu Ile Lys Phe Gln Val 
    130                 135                 140                 


Gly Leu Lys Lys Leu Asn Leu His Glu Glu Glu His Val Leu Leu Met 
145                 150                 155                 160 


Ala Ile Cys Ile Val Ser Pro Asp Arg Pro Gly Val Gln Asp Ala Ala 
                165                 170                 175     


Leu Ile Glu Ala Ile Gln Asp Arg Leu Ser Asn Thr Leu Gln Thr Tyr 
            180                 185                 190         


Ile Arg Cys Arg His Pro Pro Pro Gly Ser His Leu Leu Tyr Ala Lys 
        195                 200                 205             


Met Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser 
    210                 215                 220                 


Lys Gln Tyr Arg Cys Leu Ser Phe Gln Pro Glu Cys Ser Met Lys Leu 
225                 230                 235                 240 


Thr Pro Leu Val Leu Glu Val Phe Gly Asn Glu Ile 
                245                 250         


<210>  171
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  171

Ile Ser Asp Glu Gln Gln Lys Met Ile Asp Ile Leu Leu Glu Ala His 
1               5                   10                  15      


Arg Lys Thr Phe Asp Thr Thr Tyr Ser Asp Phe Asn Lys Phe Arg Pro 
            20                  25                  30          


Pro Val Arg Glu Asn Val Asp Pro Phe Arg Arg Ile Thr Arg Ser Ser 
        35                  40                  45              


Ser Val His Thr Gln Gly Ser Pro Ser Glu Asp Ser Asp Val Phe Thr 
    50                  55                  60                  


Ser Ser Pro Asp Ser Ser Glu His Gly Phe Phe Ser Ala Ser Leu Phe 
65                  70                  75                  80  


Gly Gln Phe Glu Tyr Ser Ser Met Gly Gly Lys Ser Gly Glu Leu Ser 
                85                  90                  95      


Met Leu Pro His Ile Ala Asp Leu Val Ser Tyr Ser Ile Gln Lys Ile 
            100                 105                 110         


Ile Gly Phe Ala Lys Met Ile Pro Gly Phe Arg Asp Leu Ile Ala Glu 
        115                 120                 125             


Asp Gln Ile Ala Leu Leu Lys Ser Ser Val Ile Glu Val Ile Met Leu 
    130                 135                 140                 


Arg Ser Asn Gln Ser Phe Ser Leu Asp Asp Met Ser Trp Thr Cys Gly 
145                 150                 155                 160 


Ser Glu Asp Phe Lys Tyr Lys Val Asp Asp Val Thr Gln Ala Gly His 
                165                 170                 175     


Asn Met Glu Leu Leu Glu Pro Leu Val Lys Phe Gln Val Gly Leu Lys 
            180                 185                 190         


Lys Leu Asp Leu His Glu Glu Glu His Val Leu Leu Met Ala Ile Cys 
        195                 200                 205             


Ile Leu Ser Pro Asp Arg Pro Gly Leu Gln Asp Lys Ala Leu Val Glu 
    210                 215                 220                 


Ser Ile Gln Asp Arg Leu Ser Ser Thr Leu Gln Thr Tyr Ile Leu Cys 
225                 230                 235                 240 


Lys His Pro Pro Pro Gly Ser Arg Leu Leu Tyr Ala Lys Met Ile Gln 
                245                 250                 255     


Lys Leu Ala Asp Leu Arg Ser Leu Asn Glu Glu His Ser Lys Gln Tyr 
            260                 265                 270         


Arg Ser Ile Ser Phe Leu Pro Glu His Ser Met Lys Leu Thr Pro Leu 
        275                 280                 285             


Met Leu Glu Val Phe Ser Asp Glu Ile 
    290                 295         


<210>  172
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  172

Leu Ser Glu Glu Gln Gln Lys Val Ile Asp Thr Leu Leu Glu Ala His 
1               5                   10                  15      


His Lys Thr Phe Asp Thr Thr Tyr Ser Asp Phe Asn Lys Phe Arg Pro 
            20                  25                  30          


Pro Val Arg Ser Lys Phe Ser Ser Arg Met Ala Thr His Ser Ser Ser 
        35                  40                  45              


Val Val Ser Gln Asp Phe Ser Ser Glu Asp Ser Asn Asp Val Phe Gly 
    50                  55                  60                  


Ser Asp Ala Phe Ala Ala Phe Pro Glu Pro Met Glu Pro Gln Met Phe 
65                  70                  75                  80  


Ser Asn Leu Asp Leu Ser Glu Glu Ser Asp Glu Ser Pro Ser Met Asn 
                85                  90                  95      


Ile Glu Leu Pro His Leu Pro Met Leu Pro His Leu Ala Asp Leu Val 
            100                 105                 110         


Ser Tyr Ser Ile Gln Lys Val Ile Gly Phe Ala Lys Met Ile Pro Gly 
        115                 120                 125             


Phe Arg Asp Leu Thr Ala Glu Asp Gln Ile Ala Leu Leu Lys Ser Ser 
    130                 135                 140                 


Ala Ile Glu Val Ile Met Leu Arg Ser Asn Gln Ser Phe Thr Met Glu 
145                 150                 155                 160 


Asp Met Ser Trp Thr Cys Gly Ser Asn Asp Phe Lys Tyr Lys Val Ser 
                165                 170                 175     


Asp Val Thr Gln Ala Gly His Ser Met Asp Leu Leu Glu Pro Leu Val 
            180                 185                 190         


Lys Phe Gln Val Gly Leu Lys Lys Leu Asn Leu His Glu Glu Glu His 
        195                 200                 205             


Val Leu Leu Met Ala Ile Cys Ile Leu Ser Pro Asp Arg Pro Gly Val 
    210                 215                 220                 


Gln Asp Thr Ser Leu Val Glu Ser Ile Gln Asp Arg Leu Ser Asp Ile 
225                 230                 235                 240 


Leu Gln Thr Tyr Ile Arg Cys Arg His Pro Pro Pro Gly Ser Arg Leu 
                245                 250                 255     


Leu Tyr Ala Lys Met Ile Gln Lys Leu Ala Asp Leu Arg Ser Leu Asn 
            260                 265                 270         


Glu Glu His Ser Lys Gln Tyr Arg Cys Leu Ser Phe Gln Pro Glu His 
        275                 280                 285             


Ser Met Gln Leu Thr Pro Leu Val Leu Glu Val Phe Gly Asn Glu Ile 
    290                 295                 300                 


<210>  173
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Glu Gln Lys Pro Ser Lys Val Glu Cys Gly Ser Asp Pro Glu Glu 
1               5                   10                  15      


Asn Ser Ala Arg Ser Pro Asp Gly Lys Arg Lys Arg Lys Asn Gly Gln 
            20                  25                  30          


Cys Ser Leu Lys Thr Ser Met Ser Gly Tyr Ile Pro Ser Tyr Leu Asp 
        35                  40                  45              


Lys Asp Glu Gln Cys Val Val Cys Gly Asp Lys Ala Thr Gly Tyr His 
    50                  55                  60                  


Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr 
65                  70                  75                  80  


Ile Gln Lys Asn Leu His Pro Thr Tyr Ser Cys Lys Tyr Asp Ser Cys 
                85                  90                  95      


Cys Val Ile Asp Lys Ile Thr Arg Asn Gln Cys Gln Leu Cys Arg Phe 
            100                 105                 110         


Lys Lys Cys Ile Ala Val Gly Met Ala Met Asp Leu Val Leu Asp Asp 
        115                 120                 125             


Ser Lys Arg Val Ala Lys Arg Lys Leu Ile Glu Gln Asn Arg Glu Arg 
    130                 135                 140                 


Arg Arg Lys Glu Glu Met Ile Arg Ser Leu Gln Gln Arg Pro Glu Pro 
145                 150                 155                 160 


Thr Pro Glu Glu Trp Asp Leu Ile His Ile Ala Thr Glu Ala His Arg 
                165                 170                 175     


Ser Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu 
            180                 185                 190         


Pro Asp Asp Ile Gly Gln Ser Pro Ile Val Ser Met Pro Asp Gly Asp 
        195                 200                 205             


Lys Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro 
    210                 215                 220                 


Ala Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Thr Phe Ser 
225                 230                 235                 240 


Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met 
                245                 250                 255     


Glu Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Asp 
            260                 265                 270         


Thr Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys 
        275                 280                 285             


Asn Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Glu Leu Gly Lys 
    290                 295                 300                 


Ser Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln 
305                 310                 315                 320 


Ala Val Leu Leu Met Ser Thr Asp Arg Ser Gly Leu Leu Cys Val Asp 
                325                 330                 335     


Lys Ile Glu Lys Ser Gln Glu Ala Tyr Leu Leu Ala Phe Glu His Tyr 
            340                 345                 350         


Val Asn His Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Gln Leu 
        355                 360                 365             


Met Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg 
    370                 375                 380                 


Phe Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu 
385                 390                 395                 400 


Phe Leu Glu Val Phe Glu Asp Gln Glu Val 
                405                 410 


<210>  174
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  174

Pro Glu Glu Trp Asp Leu Ile His Ile Ala Thr Glu Ala His Arg Ser 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu Pro 
            20                  25                  30          


Asp Asp Ile Gly Gln Ser Pro Ile Val Ser Met Pro Asp Gly Asp Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Thr Phe Ser Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Asp Thr 
            100                 105                 110         


Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Glu Leu Gly Lys Ser 
    130                 135                 140                 


Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Thr Asp Arg Ser Gly Leu Leu Cys Val Asp Lys 
                165                 170                 175     


Ile Glu Lys Ser Gln Glu Ala Tyr Leu Leu Ala Phe Glu His Tyr Val 
            180                 185                 190         


Asn His Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Gln Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  175
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  175

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  176
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  176

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  177
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  177

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Arg Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  178
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  178

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Arg Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  179
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  179

Thr Cys Pro Lys Lys Val Asn Arg Tyr Tyr Leu Asn Gly Ser Pro Lys 
1               5                   10                  15      


Pro Gly Met Pro Val Pro Glu Ala Pro Arg Pro Pro Val Val Gln Asn 
            20                  25                  30          


Gly Val Val Arg Glu Ala Asp Ser Ser Gly Ala Met Asp Asp Asp Met 
        35                  40                  45              


Val Asp Gln Asp Ile Phe Ser His Leu Ala Glu Val Ile Thr Pro Ala 
    50                  55                  60                  


Ile Ile Lys Val Val Glu Phe Ala Lys Gln Ile Pro Gly Phe Thr Lys 
65                  70                  75                  80  


Leu Val Pro Asp Asp Gln Val Ala Leu Leu Lys Asn Cys Cys Phe Glu 
                85                  90                  95      


Val Met Cys Leu Arg Ala Ala Ser Arg Phe Asp Lys Gln Arg Arg Thr 
            100                 105                 110         


Ile Thr Met Phe Gly Gly Leu Thr Val Thr Lys Glu Gln Val Ser Gln 
        115                 120                 125             


Gly Gly Leu Gly Arg Leu Ala Glu Pro Leu Phe Glu Phe Ala Glu Gly 
    130                 135                 140                 


Leu Ser Gln Leu His Leu Asp Asp Thr Glu Val Ala Leu Leu Ala Ala 
145                 150                 155                 160 


Leu Leu Val Val Ala Asp Arg Pro Gly Val Gln Asp Gln Glu Ser Ile 
                165                 170                 175     


Asp Arg Leu Gln Asp Ile Ile Leu Thr Ala Tyr Lys Asn Tyr Ile Thr 
            180                 185                 190         


Arg Gln Arg Pro His Gln Pro Val Leu Trp Gly Lys Ile Leu Met Lys 
        195                 200                 205             


Val Thr Asp Leu Arg Ala Leu Ser Val Ala His Ala Glu Gln Val Lys 
    210                 215                 220                 


Leu Val Lys Met Glu Cys Thr Asn Asp Ile Pro Pro Leu Phe Leu Glu 
225                 230                 235                 240 


Met 
    


<210>  180
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  180

Ala Glu Glu Trp Glu Leu Ile His Val Val Thr Glu Ala His Arg Ser 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ser Pro Met Ala Ser Met Pro Asp Gly Asp Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Ser Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Lys Ser 
    130                 135                 140                 


Leu Ser Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Thr Gly Leu Ile Cys Val Asp Lys 
                165                 170                 175     


Ile Glu Lys Cys Gln Glu Thr Tyr Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  181
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  181

Ser Glu Glu Trp Glu Leu Ile Arg Ile Val Thr Glu Ala His Arg Ser 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Arg Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ser Pro Met Ala Ser Met Pro Asp Gly Asp Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Ser Glu 
65                  70                  75                  80  


Leu Thr Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Asp Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Ser Gly Glu Met Ala Val Lys Arg Glu Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Arg Ser 
    130                 135                 140                 


Leu Ala Ala Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Thr Gly Leu Ile Cys Thr Asp Lys 
                165                 170                 175     


Ile Glu Lys Cys Gln Glu Thr Tyr Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn His Arg Lys His Asn Ile Pro His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  182
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  182

Ser Asp Pro Ser Gly Leu Ile Pro Asp Pro Leu Leu Asp Ser Arg Ala 
1               5                   10                  15      


Thr Ser Ser Thr Phe Pro Gln Leu Leu Thr Cys Pro Ile Leu Arg Pro 
            20                  25                  30          


Gly Phe Ser Arg Pro Ala Asp Ala Pro Pro Asp Lys Ile Gly Gln Ser 
        35                  40                  45              


Pro Val Ala Pro Thr Ser Asp Gly Asp Lys Val Asp Leu Glu Ala Phe 
    50                  55                  60                  


Ser Glu Phe Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp 
65                  70                  75                  80  


Phe Ala Lys Lys Leu Pro Met Phe Ser Glu Leu Pro Cys Glu Asp Gln 
                85                  90                  95      


Ile Ile Leu Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala 
            100                 105                 110         


Ala Met Arg Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Ser Gly Glu 
        115                 120                 125             


Met Ala Val Lys Arg Glu Gln Leu Lys Asn Gly Gly Leu Gly Val Val 
    130                 135                 140                 


Ser Asp Ala Ile Phe Asp Leu Gly Lys Ser Leu Ala Gln Phe Asn Leu 
145                 150                 155                 160 


Asp Asp Thr Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser 
                165                 170                 175     


Gly Asn Arg Arg Arg Gly Arg Pro Arg Pro Ser Pro Ala Pro Gly Ser 
            180                 185                 190         


Thr Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Arg Ser Gly Leu 
        195                 200                 205             


Thr Cys Thr Asp Lys Ile Glu Lys Cys Gln Glu Thr Tyr Leu Leu Ala 
    210                 215                 220                 


Phe Glu His Tyr Ile Asn Tyr Arg Lys His Asn Ile Pro His Phe Trp 
225                 230                 235                 240 


Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys 
                245                 250                 255     


His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Asn Glu Leu 
            260                 265                 270         


Phe Pro Pro Leu Phe Leu Glu Val 
        275                 280 


<210>  183
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  183

Asp His Glu Glu Ala Leu Ile Arg Ala Ile Leu Val Ala His Lys Gln 
1               5                   10                  15      


Thr Ser His Met Tyr Arg Arg Glu Ser Ser Ser Gly Glu Glu Ser Glu 
            20                  25                  30          


Pro Asp Ser Lys Lys Gln Lys Leu Glu Asp Glu Lys Pro Leu Ser Glu 
        35                  40                  45              


Ile Met Thr Pro Ser Ile Val Lys Val Val Glu Phe Ala Lys Arg Ile 
    50                  55                  60                  


Pro Gly Phe Thr Gly Leu His His Asp Asp Gln Ile Leu Leu Leu Lys 
65                  70                  75                  80  


Thr Cys Cys Met Glu Ile Met Cys Leu Arg Val Ala Gln Lys Phe Asp 
                85                  90                  95      


Pro Asp Ser Gln Lys Leu Ile Leu Ser Asn Gly Leu Arg Val Gly Lys 
            100                 105                 110         


Ser Asp Met Asp His Gly Val Leu Ser Glu Leu Ile Glu Pro Ile Phe 
        115                 120                 125             


Asp Phe Ala Val Ser Met Ser Arg Leu Gln Leu Thr Glu Thr Glu Met 
    130                 135                 140                 


Ala Leu Leu Ala Ala Val Leu Leu Ile Ala Gly Asp Arg Pro Gly Leu 
145                 150                 155                 160 


Lys Glu Ala Lys Leu Val Glu Thr Leu Gln Asp Ser Leu Leu Thr Ala 
                165                 170                 175     


Phe Gln His Phe Ile Asn Glu Ser Arg Pro Lys Thr Pro Val His Trp 
            180                 185                 190         


Ala Lys Ile Leu Met Lys Ile Thr Asp Leu Arg Thr Ile Ser Ala Arg 
        195                 200                 205             


His Ala Glu Arg Ile Met Cys Ile Lys Leu Asp Arg Pro Asn Glu Ile 
    210                 215                 220                 


Pro Gln Ile Phe Leu Glu Met 
225                 230     


<210>  184
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  184

Asp Glu Glu Trp Glu Leu Ile Lys Thr Val Thr Glu Ala His Val Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Ser His Trp Lys Gln Lys Arg Lys Phe Leu Pro 
            20                  25                  30          


Glu Asp Ile Gly Gln Ala Pro Ile Val Asn Ala Pro Glu Gly Gly Lys 
        35                  40                  45              


Val Asp Leu Glu Ala Phe Ser His Phe Thr Lys Ile Ile Thr Pro Ala 
    50                  55                  60                  


Ile Thr Arg Val Val Asp Phe Ala Lys Lys Leu Pro Met Phe Cys Glu 
65                  70                  75                  80  


Leu Pro Cys Glu Asp Gln Ile Ile Leu Leu Lys Gly Cys Cys Met Glu 
                85                  90                  95      


Ile Met Ser Leu Arg Ala Ala Val Arg Tyr Asp Pro Glu Ser Glu Thr 
            100                 105                 110         


Leu Thr Leu Asn Gly Glu Met Ala Val Thr Arg Gly Gln Leu Lys Asn 
        115                 120                 125             


Gly Gly Leu Gly Val Val Ser Asp Ala Ile Phe Asp Leu Gly Met Ser 
    130                 135                 140                 


Leu Ser Ser Phe Asn Leu Asp Asp Thr Glu Val Ala Leu Leu Gln Ala 
145                 150                 155                 160 


Val Leu Leu Met Ser Ser Asp Arg Pro Gly Leu Ala Cys Val Glu Arg 
                165                 170                 175     


Ile Glu Lys Tyr Gln Asp Ser Phe Leu Leu Ala Phe Glu His Tyr Ile 
            180                 185                 190         


Asn Tyr Arg Lys His His Val Thr His Phe Trp Pro Lys Leu Leu Met 
        195                 200                 205             


Lys Val Thr Asp Leu Arg Met Ile Gly Ala Cys His Ala Ser Arg Phe 
    210                 215                 220                 


Leu His Met Lys Val Glu Cys Pro Thr Glu Leu Phe Pro Pro Leu Phe 
225                 230                 235                 240 


Leu Glu Val 
            


<210>  185
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  185

Gln Glu Glu Trp Glu Met Ile Arg Val Val Thr Glu Ala His Met Ala 
1               5                   10                  15      


Thr Asn Ala Gln Gly Asn His Trp Lys Gln Lys Arg Lys Phe Leu Ser 
            20                  25                  30          


Ala Val Gly Val Lys Glu Ala Lys Pro Glu Asp Ile Gly Ser Ala Pro 
        35                  40                  45              


Ile Val Asn Ala Pro Glu Gly Asn Lys Val Asp Ile Glu Ala Phe Ser 
    50                  55                  60                  


Gln Phe Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe 
65                  70                  75                  80  


Ala Lys Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile 
                85                  90                  95      


Ile Leu Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala 
            100                 105                 110         


Val Arg Tyr Asp Pro Glu Ser Asp Thr Leu Thr Leu Asn Gly Glu Met 
        115                 120                 125             


Ala Val Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser 
    130                 135                 140                 


Asp Ala Ile Phe Asp Leu Gly Val Ser Leu Ser Ser Phe Asn Leu Asp 
145                 150                 155                 160 


Asp Ser Glu Val Ala Leu Leu Gln Ala Val Ile Leu Leu Ser Ser Asp 
                165                 170                 175     


Arg Pro Gly Leu Thr Ser Val Glu Arg Ile Glu Arg Cys Gln Glu Glu 
            180                 185                 190         


Phe Leu Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His Lys Val 
        195                 200                 205             


Ala His Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met 
    210                 215                 220                 


Ile Gly Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys 
225                 230                 235                 240 


Pro Thr Glu Leu Phe Pro Pro Leu Phe Leu Glu Val 
                245                 250         


<210>  186
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Phe Asp Cys Met Asp Val Leu Ser Val Ser Pro Gly Gln Ile Leu 
1               5                   10                  15      


Asp Phe Tyr Thr Ala Ser Pro Ser Ser Cys Met Leu Gln Glu Lys Ala 
            20                  25                  30          


Leu Lys Ala Cys Phe Ser Gly Leu Thr Gln Thr Glu Trp Gln His Arg 
        35                  40                  45              


His Thr Ala Gln Ser Ile Glu Thr Gln Ser Thr Ser Ser Glu Glu Leu 
    50                  55                  60                  


Val Pro Ser Pro Pro Ser Pro Leu Pro Pro Pro Arg Val Tyr Lys Pro 
65                  70                  75                  80  


Cys Phe Val Cys Gln Asp Lys Ser Ser Gly Tyr His Tyr Gly Val Ser 
                85                  90                  95      


Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Gln Lys Asn 
            100                 105                 110         


Met Ile Tyr Thr Cys His Arg Asp Lys Asn Cys Val Ile Asn Lys Val 
        115                 120                 125             


Thr Arg Asn Arg Cys Gln Tyr Cys Arg Leu Gln Lys Cys Phe Glu Val 
    130                 135                 140                 


Gly Met Ser Lys Glu Ser Val Arg Asn Asp Arg Asn Lys Lys Lys Lys 
145                 150                 155                 160 


Glu Thr Ser Lys Gln Glu Cys Thr Glu Ser Tyr Glu Met Thr Ala Glu 
                165                 170                 175     


Leu Asp Asp Leu Thr Glu Lys Ile Arg Lys Ala His Gln Glu Thr Phe 
            180                 185                 190         


Pro Ser Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ala Asp 
        195                 200                 205             


His Arg Val Arg Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu 
    210                 215                 220                 


Ala Thr Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro 
225                 230                 235                 240 


Gly Phe Thr Gly Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala 
                245                 250                 255     


Ala Cys Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro 
            260                 265                 270         


Glu Gln Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr 
        275                 280                 285             


Gln Met His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Thr 
    290                 295                 300                 


Phe Ala Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly 
305                 310                 315                 320 


Leu Leu Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu 
                325                 330                 335     


Glu Pro Thr Lys Val Asp Lys Leu Gln Glu Pro Leu Leu Glu Ala Leu 
            340                 345                 350         


Lys Ile Tyr Ile Arg Lys Arg Arg Pro Ser Lys Pro His Met Phe Pro 
        355                 360                 365             


Lys Ile Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly 
    370                 375                 380                 


Ala Glu Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro 
385                 390                 395                 400 


Pro Leu Ile Gln Glu Met Leu Glu Asn Ser Glu Gly His Glu Pro Leu 
                405                 410                 415     


Thr Pro Ser Ser Ser Gly Asn Thr Ala Glu His Ser Pro Ser Ile Ser 
            420                 425                 430         


Pro Ser Ser Val Glu Asn Ser Gly Val Ser Gln Ser Pro Leu Val Gln 
        435                 440                 445             


<210>  187
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  187

Asp Leu Thr Glu Lys Ile Arg Lys Ala His Gln Glu Thr Phe Pro Ser 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ala Asp His Arg 
            20                  25                  30          


Val Arg Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu Ala Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro Gly Phe 
    50                  55                  60                  


Thr Gly Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Thr Phe Ala 
        115                 120                 125             


Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu Glu Pro 
145                 150                 155                 160 


Thr Lys Val Asp Lys Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Ile 
                165                 170                 175     


Tyr Ile Arg Lys Arg Arg Pro Ser Lys Pro His Met Phe Pro Lys Ile 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly Ala Glu 
        195                 200                 205             


Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro Pro Leu 
    210                 215                 220                 


Ile Gln Glu Met Leu Glu Asn 
225                 230     


<210>  188
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  188

Asp Leu Thr Glu Lys Ile Arg Lys Ala His Gln Glu Thr Phe Pro Ser 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ala Asp His Arg 
            20                  25                  30          


Val Arg Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu Ala Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro Gly Phe 
    50                  55                  60                  


Thr Gly Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Thr Phe Ala 
        115                 120                 125             


Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu Glu Pro 
145                 150                 155                 160 


Thr Lys Val Asp Lys Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Ile 
                165                 170                 175     


Tyr Ile Arg Lys Arg Arg Pro Ser Lys Pro His Met Phe Pro Lys Ile 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly Ala Glu 
        195                 200                 205             


Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro Pro Leu 
    210                 215                 220                 


Ile Gln Glu Met Leu Glu Asn 
225                 230     


<210>  189
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  189

Ala Leu Val Thr Ser Val His Lys Phe His Val Glu Thr Phe Pro Leu 
1               5                   10                  15      


Ser Ser Glu Leu Lys Lys Tyr Gln Ile Pro Ser Pro Pro Ile Val Lys 
            20                  25                  30          


Asp Thr Ser Ala Lys Thr Asp Ser Asn Leu Trp Glu Lys Phe Ala Glu 
        35                  40                  45              


Leu Ser Thr Lys Cys Ile Val Lys Ile Val Glu Phe Ala Lys Gly Ile 
    50                  55                  60                  


Pro Gly Phe Gln Asp Phe Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys 
65                  70                  75                  80  


Cys Ala Cys Leu Glu Val Leu Phe Leu Arg Ile Cys Ser Arg Phe Ser 
                85                  90                  95      


Pro Glu His Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Thr Arg 
            100                 105                 110         


Lys Gln Met Arg Val Cys Gly Phe Gly Pro Ile Thr Glu Gln Val Phe 
        115                 120                 125             


Ser Phe Ala Gln Ser Leu His Pro Leu Asn Ala Asp Ala Thr Glu Ile 
    130                 135                 140                 


Gly Leu Leu Ser Ala Ile Cys Leu Val Ser Ala Asp Arg Val Asp Leu 
145                 150                 155                 160 


Glu Glu Pro Asp Lys Val Glu Leu Leu Gln Glu Ser Leu Val Glu Gly 
                165                 170                 175     


Leu Lys Tyr Tyr Ala Arg Lys Arg Arg Pro His Thr Pro Gln Val Phe 
            180                 185                 190         


Pro Lys Leu Ile Ile Lys Ile Ser Asp Leu Arg Ser Ile Ser Leu Lys 
        195                 200                 205             


Gly Ala Asp Arg Val Val Thr Val Lys Thr Glu Ile Pro Cys Gly Ala 
    210                 215                 220                 


Met Pro Pro Leu Met Ser Glu Met Leu Glu Asn 
225                 230                 235 


<210>  190
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  190

Asp Leu Thr Glu Lys Ile Arg Lys Ala His Gln Glu Thr Phe Pro Ser 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ala Asp His Arg 
            20                  25                  30          


Val Arg Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu Ala Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro Gly Phe 
    50                  55                  60                  


Thr Ser Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Thr Phe Ala 
        115                 120                 125             


Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu Glu Pro 
145                 150                 155                 160 


Met Lys Val Asp Lys Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Ile 
                165                 170                 175     


Tyr Ile Arg Lys Arg Arg Pro Asn Lys Pro His Met Phe Pro Lys Ile 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly Ala Glu 
        195                 200                 205             


Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro Pro Leu 
    210                 215                 220                 


Ile Gln Glu Met Leu Glu Asn 
225                 230     


<210>  191
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  191

Glu Leu Ile Gln Lys Val Ser Lys Ala His Gln Glu Thr Phe Pro Ser 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ala Asp Gln Arg 
            20                  25                  30          


Val Gln Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu Ser Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro Gly Phe 
    50                  55                  60                  


Thr Thr Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ser Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Met Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Ser Phe Ala 
        115                 120                 125             


Asp Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Met Asp Leu Glu Glu Pro 
145                 150                 155                 160 


Glu Lys Val Glu Lys Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Phe 
                165                 170                 175     


Tyr Ala Arg Arg Arg Arg Pro Asp Lys Pro Tyr Met Phe Pro Arg Met 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Gly Ile Ser Thr Lys Gly Ala Glu 
        195                 200                 205             


Arg Ala Ile Thr Leu Lys Leu Glu Ile Pro Gly Pro Met Pro Pro Leu 
    210                 215                 220                 


Ile Arg Glu Met Leu Glu Asn 
225                 230     


<210>  192
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  192

Glu Leu Val Asn Lys Val Ser Lys Ala His Gln Glu Thr Phe Pro Ser 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ser Asp His Arg 
            20                  25                  30          


Ile Gln Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu Ser Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro Gly Phe 
    50                  55                  60                  


Thr Thr Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ser Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Met Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Ala Phe Ala 
        115                 120                 125             


Gly Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Met Asp Leu Glu Glu Pro 
145                 150                 155                 160 


Glu Arg Val Asp Arg Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Ile 
                165                 170                 175     


Tyr Ala Arg Arg Arg Arg Pro Asn Lys Pro His Met Phe Pro Arg Met 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Gly Ile Ser Thr Lys Gly Ala Glu 
        195                 200                 205             


Arg Ala Ile Thr Leu Lys Met Glu Ile Pro Gly Pro Met Pro Pro Leu 
    210                 215                 220                 


Ile Arg Glu Met Leu Glu Asn 
225                 230     


<210>  193
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  193

Asp Ile Leu Gln Glu Val Leu Arg Ala His Arg Asp Thr Phe Pro Gln 
1               5                   10                  15      


Arg Pro Leu His Pro Ile His Asn Ala Val Ser Ala Gly Asn Ile Asp 
            20                  25                  30          


Ile Asp Met Val Met Phe Asp Tyr Val Thr Asp Met Ser Ser Arg Ala 
        35                  40                  45              


Ile Val Met Val Val Asp Phe Ala Lys Lys Leu Pro Gly Phe Leu Ser 
    50                  55                  60                  


Leu Ser Thr Gln Asp Gln Ile Thr Leu Leu Lys Ala Ser Cys Leu Asp 
65                  70                  75                  80  


Ile Met Ile Leu Arg Ile Cys Ser Arg Phe Asn Pro Gln Asp Ala Ser 
                85                  90                  95      


Val Thr Phe Thr Thr Gly Leu Thr Leu Thr Gln Gly Gln Leu Lys Ala 
            100                 105                 110         


Gly Gly Phe Gly Ser Leu Leu Asp Val Ile Phe Thr Phe Ala Ser Ser 
        115                 120                 125             


Leu Ser Arg Met His Ile Asp Glu Thr Glu Ile Ala Leu Leu Ser Ala 
    130                 135                 140                 


Ile Cys Leu Ile Ser Glu Asp Arg Thr Gly Leu Glu Asp Ala Pro Arg 
145                 150                 155                 160 


Ile Glu Lys Met Gln Glu Pro Leu Leu Glu Gly Leu Arg Leu Tyr Val 
                165                 170                 175     


Arg Lys Arg Arg Pro Lys Glu Ser His Phe Phe Ala Lys Leu Leu Met 
            180                 185                 190         


Lys Ile Thr Asp Leu Arg Cys Ile Ser Val Lys Ser Ala Glu Lys Val 
        195                 200                 205             


Phe Asp Met Lys Val Glu Phe Val Lys Glu Met Pro Ala Leu Ile Ser 
    210                 215                 220                 


Glu Met Ile Asp Lys 
225                 


<210>  194
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  194

Thr Ile Ile Thr Thr Val Arg Glu Ala His Met Ala Thr Leu Pro Asp 
1               5                   10                  15      


Met Gly Lys Leu Pro Lys Tyr Lys Val Lys Asn Ala Ala Glu Gln Arg 
            20                  25                  30          


Gly Pro Thr Asp Ile Glu Leu Trp Gln His Phe Ser Asp Leu Cys Thr 
        35                  40                  45              


Glu Thr Ile Ile Lys Ile Val Gln Phe Ala Lys Lys Val Pro Gly Phe 
    50                  55                  60                  


Thr Thr Phe Gly Thr Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Ile Leu Arg Leu Ala Thr Arg Leu Asp Lys Glu Ser 
                85                  90                  95      


Asp Thr Val Thr Phe Ile Asn Gly Met Met Leu Ser Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Gly Val Phe Thr Phe Ala 
        115                 120                 125             


Glu Gly Met Gln Lys Leu Leu Phe Asp Glu Thr Glu Ile Gly Leu Met 
    130                 135                 140                 


Cys Ser Ile Cys Leu Val Cys Gly Asp Arg Gln Gly Leu Glu Asp Ile 
145                 150                 155                 160 


Gln Arg Ala Glu Asn Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Ala 
                165                 170                 175     


Tyr Ser Arg Arg Arg Ile Pro Asp Asp Pro Gln Arg Phe Pro Lys Met 
            180                 185                 190         


Ile Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ser Lys Gly Ala Glu 
        195                 200                 205             


Arg Val Ile Thr Leu Lys Met Glu Leu Ser Ser Pro Met Pro Pro Leu 
    210                 215                 220                 


Ile Ala Glu Ile Trp Glu Lys 
225                 230     


<210>  195
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  195

Asp Leu Thr Glu Lys Ile Arg Lys Ala His Gln Glu Thr Phe Pro Ser 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Ser Ser Ala Asp His Arg 
            20                  25                  30          


Val Arg Leu Asp Leu Gly Leu Trp Asp Lys Phe Ser Glu Leu Ala Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Ile Val Glu Phe Ala Lys Arg Leu Pro Gly Phe 
    50                  55                  60                  


Thr Gly Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Thr Phe Ala 
        115                 120                 125             


Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Thr Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu Glu Pro 
145                 150                 155                 160 


Thr Lys Val Asp Lys Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Ile 
                165                 170                 175     


Tyr Ile Arg Lys Arg Arg Pro Ser Lys Pro His Met Phe Pro Lys Ile 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly Ala Glu 
        195                 200                 205             


Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro Pro Leu 
    210                 215                 220                 


Ile Gln Glu Met Leu Glu Asn 
225                 230     


<210>  196
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  196

Glu Leu Ile Glu Lys Val Arg Lys Ala His Gln Glu Thr Phe Pro Ala 
1               5                   10                  15      


Leu Cys Gln Leu Gly Lys Tyr Thr Thr Asn Asn Ser Ser Glu Gln Arg 
            20                  25                  30          


Val Ser Leu Asp Ile Asp Leu Trp Asp Lys Phe Ser Glu Leu Ser Thr 
        35                  40                  45              


Lys Cys Ile Ile Lys Thr Val Glu Phe Ala Lys Gln Leu Pro Gly Phe 
    50                  55                  60                  


Thr Thr Leu Thr Ile Ala Asp Gln Ile Thr Leu Leu Lys Ala Ala Cys 
65                  70                  75                  80  


Leu Asp Ile Leu Ile Leu Arg Ile Cys Thr Arg Tyr Thr Pro Glu Gln 
                85                  90                  95      


Asp Thr Met Thr Phe Ser Asp Gly Leu Thr Leu Asn Arg Thr Gln Met 
            100                 105                 110         


His Asn Ala Gly Phe Gly Pro Leu Thr Asp Leu Val Phe Ala Phe Ala 
        115                 120                 125             


Asn Gln Leu Leu Pro Leu Glu Met Asp Asp Ala Glu Thr Gly Leu Leu 
    130                 135                 140                 


Ser Ala Ile Cys Leu Ile Cys Gly Asp Arg Gln Asp Leu Glu Gln Pro 
145                 150                 155                 160 


Asp Arg Val Asp Met Leu Gln Glu Pro Leu Leu Glu Ala Leu Lys Val 
                165                 170                 175     


Tyr Val Arg Lys Arg Arg Pro Ser Arg Pro His Met Phe Pro Lys Met 
            180                 185                 190         


Leu Met Lys Ile Thr Asp Leu Arg Ser Ile Ser Ala Lys Gly Ala Glu 
        195                 200                 205             


Arg Val Ile Thr Leu Lys Met Glu Ile Pro Gly Ser Met Pro Pro Leu 
    210                 215                 220                 


Ile Gln Glu Met Leu Glu Asn 
225                 230     


<210>  197
<211>  512
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Leu Ser Asp Asp Gly 
1               5                   10                  15      


Val Asp Leu Lys Thr Gln Pro Val Arg Asn Thr Glu Arg Thr Ile Tyr 
            20                  25                  30          


Val Arg Asp Pro Thr Ser Asn Lys Gln Gln Arg Pro Val Pro Glu Ser 
        35                  40                  45              


Gln Leu Leu Pro Gly Gln Arg Phe Gln Thr Lys Asp Pro Glu Glu Gln 
    50                  55                  60                  


Gly Asp Ile Val Val Ala Leu Tyr Pro Tyr Asp Gly Ile His Pro Asp 
65                  70                  75                  80  


Asp Leu Ser Phe Lys Lys Gly Glu Lys Met Lys Val Leu Glu Glu His 
                85                  90                  95      


Gly Glu Trp Trp Lys Ala Lys Ser Leu Leu Thr Lys Lys Glu Gly Phe 
            100                 105                 110         


Ile Pro Ser Asn Tyr Val Ala Lys Leu Asn Thr Leu Glu Thr Glu Glu 
        115                 120                 125             


Trp Phe Phe Lys Asp Ile Thr Arg Lys Asp Ala Glu Arg Gln Leu Leu 
    130                 135                 140                 


Ala Pro Gly Asn Ser Ala Gly Ala Phe Leu Ile Arg Glu Ser Glu Thr 
145                 150                 155                 160 


Leu Lys Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Pro Val His 
                165                 170                 175     


Gly Asp Val Ile Lys His Tyr Lys Ile Arg Ser Leu Asp Asn Gly Gly 
            180                 185                 190         


Tyr Tyr Ile Ser Pro Arg Ile Thr Phe Pro Cys Ile Ser Asp Met Ile 
        195                 200                 205             


Lys His Tyr Gln Lys Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys 
    210                 215                 220                 


Ala Cys Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp 
225                 230                 235                 240 


Glu Ile Pro Arg Glu Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly 
                245                 250                 255     


Gln Phe Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val 
            260                 265                 270         


Ala Val Lys Thr Leu Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu 
        275                 280                 285             


Glu Glu Ala Asn Leu Met Lys Thr Leu Gln His Asp Lys Leu Val Arg 
    290                 295                 300                 


Leu Tyr Ala Val Val Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu 
305                 310                 315                 320 


Tyr Met Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly 
                325                 330                 335     


Gly Lys Val Leu Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala 
            340                 345                 350         


Glu Gly Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu 
        355                 360                 365             


Arg Ala Ala Asn Val Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala 
    370                 375                 380                 


Asp Phe Gly Leu Ala Arg Val Ile Glu Asp Asn Glu Tyr Thr Ala Arg 
385                 390                 395                 400 


Glu Gly Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn 
                405                 410                 415     


Phe Gly Cys Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu 
            420                 425                 430         


Leu Tyr Glu Ile Val Thr Tyr Gly Lys Ile Pro Tyr Pro Gly Arg Thr 
        435                 440                 445             


Asn Ala Asp Val Met Thr Ala Leu Ser Gln Gly Tyr Arg Met Pro Arg 
    450                 455                 460                 


Val Glu Asn Cys Pro Asp Glu Leu Tyr Asp Ile Met Lys Met Cys Trp 
465                 470                 475                 480 


Lys Glu Lys Ala Glu Glu Arg Pro Thr Phe Asp Tyr Leu Gln Ser Val 
                485                 490                 495     


Leu Asp Asp Phe Tyr Thr Ala Thr Glu Gly Gln Tyr Gln Gln Gln Pro 
            500                 505                 510         


<210>  198
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  198

Tyr Gln Lys Gln Ala Asp Gly Leu Cys Arg Arg Leu Glu Lys Ala Cys 
1               5                   10                  15      


Ile Ser Pro Lys Pro Gln Lys Pro Trp Asp Lys Asp Ala Trp Glu Ile 
            20                  25                  30          


Pro Arg Glu Ser Ile Lys Leu Val Lys Arg Leu Gly Ala Gly Gln Phe 
        35                  40                  45              


Gly Glu Val Trp Met Gly Tyr Tyr Asn Asn Ser Thr Lys Val Ala Val 
    50                  55                  60                  


Lys Thr Leu Lys Pro Gly Thr Met Ser Val Gln Ala Phe Leu Glu Glu 
65                  70                  75                  80  


Ala Asn Leu Met Lys Thr Leu Gln His Asp Lys Leu Val Arg Leu Tyr 
                85                  90                  95      


Ala Val Val Thr Arg Glu Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met 
            100                 105                 110         


Ala Lys Gly Ser Leu Leu Asp Phe Leu Lys Ser Asp Glu Gly Gly Lys 
        115                 120                 125             


Val Leu Leu Pro Lys Leu Ile Asp Phe Ser Ala Gln Ile Ala Glu Gly 
    130                 135                 140                 


Met Ala Tyr Ile Glu Arg Lys Asn Tyr Ile His Arg Asp Leu Arg Ala 
145                 150                 155                 160 


Ala Asn Val Leu Val Ser Glu Ser Leu Met Cys Lys Ile Ala Asp Phe 
                165                 170                 175     


Gly Leu Ala Arg Val Ile Glu 
            180             


<210>  199
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  199

Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala Lys Phe Pro Ile Lys Trp 
1               5                   10                  15      


Thr Ala Pro Glu Ala Ile Asn Phe Gly Cys Phe Thr Ile Lys Ser Asp 
            20                  25                  30          


Val Trp Ser Phe Gly Ile Leu Leu Tyr Glu Ile Val Thr Tyr Gly Lys 
        35                  40                  45              


Ile Pro Tyr Pro Gly Arg Thr Asn Ala Asp Val Met Thr Ala Leu Ser 
    50                  55                  60                  


Gln Gly Tyr Arg Met Pro Arg Val Glu Asn Cys Pro Asp Glu Leu Tyr 
65                  70                  75                  80  


Asp Ile Met Lys Met Cys Trp Lys Glu Lys Ala Glu Glu Arg Pro Thr 
                85                  90                  95      


Phe Asp Tyr Leu Gln Ser Val Leu Asp Asp Phe Tyr Thr Ala Thr Glu 
            100                 105                 110         


Gly Gln Tyr Gln Gln Gln Pro 
        115                 


<210>  200
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ala Ala Ala Tyr Leu Asp Pro Asn Leu Asn His Thr Pro Ser Ser 
1               5                   10                  15      


Ser Thr Lys Thr His Leu Gly Thr Gly Thr Glu Arg Ser Pro Gly Ala 
            20                  25                  30          


Met Glu Arg Val Leu Lys Val Phe His Tyr Phe Glu Ser Ser Asn Glu 
        35                  40                  45              


Pro Thr Thr Trp Ala Ser Ile Ile Arg His Gly Asp Ala Thr Asp Val 
    50                  55                  60                  


Arg Gly Ile Ile Gln Lys Ile Val Asp Ser His Lys Val Lys His Val 
65                  70                  75                  80  


Ala Cys Tyr Gly Phe Arg Leu Ser His Leu Arg Ser Glu Glu Val His 
                85                  90                  95      


Trp Leu His Val Asp Met Gly Val Ser Ser Val Arg Glu Lys Tyr Glu 
            100                 105                 110         


Leu Ala His Pro Pro Glu Glu Trp Lys Tyr Glu Leu Arg Ile Arg Tyr 
        115                 120                 125             


Leu Pro Lys Gly Phe Leu Asn Gln Phe Thr Glu Asp Lys Pro Thr Leu 
    130                 135                 140                 


Asn Phe Phe Tyr Gln Gln Val Lys Ser Asp Tyr Met Leu Glu Ile Ala 
145                 150                 155                 160 


Asp Gln Val Asp Gln Asp Ile Ala Leu Lys Leu Gly Cys Leu Glu Ile 
                165                 170                 175     


Arg Arg Ser Tyr Trp Glu Met Arg Gly Asn Ala Leu Glu Lys Lys Ser 
            180                 185                 190         


Asn Tyr Glu Val Leu Glu Lys Asp Val Gly Leu Lys Arg Phe Phe Pro 
        195                 200                 205             


Lys Ser Leu Leu Asp Ser Val Lys Ala Lys Thr Leu Arg Lys Leu Ile 
    210                 215                 220                 


Gln Gln Thr Phe Arg Gln Phe Ala Asn Leu Asn Arg Glu Glu Ser Ile 
225                 230                 235                 240 


Leu Lys Phe Phe Glu Ile Leu Ser Pro Val Tyr Arg Phe Asp Lys Glu 
                245                 250                 255     


Cys Phe Lys Cys Ala Leu Gly Ser Ser Trp Ile Ile Ser Val Glu Leu 
            260                 265                 270         


Ala Ile Gly Pro Glu Glu Gly Ile Ser Tyr Leu Thr Asp Lys Gly Cys 
        275                 280                 285             


Asn Pro Thr His Leu Ala Asp Phe Asn Gln Val Gln Thr Ile Gln Tyr 
    290                 295                 300                 


Ser Asn Ser Glu Asp Lys Asp Arg Lys Gly Met Leu Gln Leu Lys Ile 
305                 310                 315                 320 


Ala Gly Ala Pro Glu Pro Leu Thr Val Thr Ala Pro Ser Leu Thr Ile 
                325                 330                 335     


Ala Glu Asn Met Ala Asp Leu Ile Asp Gly Tyr Cys Arg Leu Val Asn 
            340                 345                 350         


Gly Ala Thr Gln Ser Phe Ile Ile Arg Pro Gln Lys Glu Gly Glu Arg 
        355                 360                 365             


Ala Leu Pro Ser Ile Pro Lys Leu Ala Asn Asn Glu Lys Gln Gly Met 
    370                 375                 380                 


Arg Thr His Ala Val Ser Val Ser Glu Thr Asp Asp Tyr Ala Glu Ile 
385                 390                 395                 400 


Ile Asp Glu Glu Asp Thr Tyr Thr Met Pro Ser Thr Arg Asp Tyr Glu 
                405                 410                 415     


Ile Gln Arg Glu Arg Ile Glu Leu Gly Arg Cys Ile Gly Glu Gly Gln 
            420                 425                 430         


Phe Gly Asp Val His Gln Gly Val Tyr Leu Ser Pro Glu Asn Pro Ala 
        435                 440                 445             


Leu Ala Val Ala Ile Lys Thr Cys Lys Asn Cys Thr Ser Asp Ser Val 
    450                 455                 460                 


Arg Glu Lys Phe Leu Gln Glu Ala Leu Thr Met Arg Gln Phe Asp His 
465                 470                 475                 480 


Pro His Ile Val Lys Leu Ile Gly Val Ile Thr Glu Asn Pro Val Trp 
                485                 490                 495     


Ile Ile Met Glu Leu Cys Thr Leu Gly Glu Leu Arg Ser Phe Leu Gln 
            500                 505                 510         


Val Arg Lys Tyr Ser Leu Asp Leu Ala Ser Leu Ile Leu Tyr Ala Tyr 
        515                 520                 525             


Gln Leu Ser Thr Ala Leu Ala Tyr Leu Glu Ser Lys Arg Phe Val His 
    530                 535                 540                 


Arg Asp Ile Ala Ala Arg Asn Val Leu Val Ser Ser Asn Asp Cys Val 
545                 550                 555                 560 


Lys Leu Gly Asp Phe Gly Leu Ser Arg Tyr Met Glu Asp Ser Thr Tyr 
                565                 570                 575     


Tyr Lys Ala Ser Lys Gly Lys Leu Pro Ile Lys Trp Met Ala Pro Glu 
            580                 585                 590         


Ser Ile Asn Phe Arg Arg Phe Thr Ser Ala Ser Asp Val Trp Met Phe 
        595                 600                 605             


Gly Val Cys Met Trp Glu Ile Leu Met His Gly Val Lys Pro Phe Gln 
    610                 615                 620                 


Gly Val Lys Asn Asn Asp Val Ile Gly Arg Ile Glu Asn Gly Glu Arg 
625                 630                 635                 640 


Leu Pro Met Pro Pro Asn Cys Pro Pro Thr Leu Tyr Ser Leu Met Thr 
                645                 650                 655     


Lys Cys Trp Ala Tyr Asp Pro Ser Arg Arg Pro Arg Phe Thr Glu Leu 
            660                 665                 670         


Lys Ala Gln Leu Ser Thr Ile Leu Glu Glu Glu Lys Val Gln Gln Glu 
        675                 680                 685             


Glu Arg Met Arg Met Glu Ser Arg Arg Gln Ala Thr Val Ser Trp Asp 
    690                 695                 700                 


Ser Gly Gly Ser Asp Glu Ala Pro Pro Lys Pro Ser Arg Pro Gly Tyr 
705                 710                 715                 720 


Pro Ser Pro Arg Ser Ser Glu Gly Phe Tyr Pro Ser Pro Gln His Met 
                725                 730                 735     


Val Gln Thr Asn His Tyr Gln Ile Ser Gly Tyr Pro Gly Ser His Gly 
            740                 745                 750         


Ile Pro Ala Met Ala Gly Ser Ile Tyr Pro Gly Gln Ala Ser Leu Leu 
        755                 760                 765             


Asp Gln Thr Glu Leu Trp Asn His Arg Pro Gln Glu Met Ser Met Trp 
    770                 775                 780                 


Gln Pro Ser Val Glu Asp Ser Ala Ala Leu Asp Leu Arg Gly Met Gly 
785                 790                 795                 800 


Gln Val Leu Pro Pro His Leu Met Glu Glu Arg Leu Ile Arg Gln Gln 
                805                 810                 815     


Gln Glu Met Glu Glu Asp Gln Arg Trp Leu Glu Lys Glu Glu Arg Phe 
            820                 825                 830         


Leu Lys Pro Asp Val Arg Leu Ser Arg Gly Ser Ile Asp Arg Glu Asp 
        835                 840                 845             


Gly Ser Phe Gln Gly Pro Thr Gly Asn Gln His Ile Tyr Gln Pro Val 
    850                 855                 860                 


Gly Lys Pro Asp Pro Ala Ala Pro Pro Lys Lys Pro Pro Arg Pro Gly 
865                 870                 875                 880 


Ala Pro Gly His Leu Ser Asn Leu Ser Ser Ile Ser Ser Pro Ala Glu 
                885                 890                 895     


Ser Tyr Asn Glu Gly Val Lys Pro Trp Arg Leu Gln Pro Gln Glu Ile 
            900                 905                 910         


Ser Pro Pro Pro Thr Ala Asn Leu Asp Arg Ser Asn Asp Lys Val Tyr 
        915                 920                 925             


Glu Asn Val Thr Gly Leu Val Lys Ala Val Ile Glu Met Ser Ser Lys 
    930                 935                 940                 


Ile Gln Pro Ala Pro Pro Glu Glu Tyr Val Pro Met Val Lys Glu Val 
945                 950                 955                 960 


Gly Leu Ala Leu Arg Thr Leu Leu Ala Thr Val Asp Glu Thr Ile Pro 
                965                 970                 975     


Ile Leu Pro Ala Ser Thr His Arg Glu Ile Glu Met Ala Gln Lys Leu 
            980                 985                 990         


Leu Asn Ser Asp Leu Gly Glu Leu  Ile Ser Lys Met Lys  Leu Ala Gln 
        995                 1000                 1005             


Gln Tyr  Val Met Thr Ser Leu  Gln Gln Glu Tyr Lys  Lys Gln Met 
    1010                 1015                 1020             


Leu Thr  Ala Ala His Ala Leu  Ala Val Asp Ala Lys  Asn Leu Leu 
    1025                 1030                 1035             


Asp Val  Ile Asp Gln Ala Arg  Leu Lys Met Leu Gly  Gln Thr Arg 
    1040                 1045                 1050             


Pro His  
    1055 


<210>  201
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Gly Ser Lys Met Asn Leu Ile Glu His Ser His Leu Pro Thr Thr 
1               5                   10                  15      


Asp Glu Phe Ser Phe Ser Glu Asn Leu Phe Gly Val Leu Thr Glu Gln 
            20                  25                  30          


Val Ala Gly Pro Leu Gly Gln Asn Leu Glu Val Glu Pro Tyr Ser Gln 
        35                  40                  45              


Tyr Ser Asn Val Gln Phe Pro Gln Val Gln Pro Gln Ile Ser Ser Ser 
    50                  55                  60                  


Ser Tyr Tyr Ser Asn Leu Gly Phe Tyr Pro Gln Gln Pro Glu Glu Trp 
65                  70                  75                  80  


Tyr Ser Pro Gly Ile Tyr Glu Leu Arg Arg Met Pro Ala Glu Thr Leu 
                85                  90                  95      


Tyr Gln Gly Glu Thr Glu Val Ala Glu Met Pro Val Thr Lys Lys Pro 
            100                 105                 110         


Arg Met Gly Ala Ser Ala Gly Arg Ile Lys Gly Asp Glu Leu Cys Val 
        115                 120                 125             


Val Cys Gly Asp Arg Ala Ser Gly Tyr His Tyr Asn Ala Leu Thr Cys 
    130                 135                 140                 


Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Ile Thr Lys Asn Ala Val 
145                 150                 155                 160 


Tyr Lys Cys Lys Asn Gly Gly Asn Cys Val Met Asp Met Tyr Met Arg 
                165                 170                 175     


Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Lys Glu Met Gly Met 
            180                 185                 190         


Leu Ala Glu Cys Leu Leu Thr Glu Ile Gln Cys Lys Ser Lys Arg Leu 
        195                 200                 205             


Arg Lys Asn Val Lys Gln His Ala Asp Gln Thr Val Asn Glu Asp Ser 
    210                 215                 220                 


Glu Gly Arg Asp Leu Arg Gln Val Thr Ser Thr Thr Lys Ser Cys Arg 
225                 230                 235                 240 


Glu Lys Thr Glu Leu Thr Pro Asp Gln Gln Thr Leu Leu His Phe Ile 
                245                 250                 255     


Met Asp Ser Tyr Asn Lys Gln Arg Met Pro Gln Glu Ile Thr Asn Lys 
            260                 265                 270         


Ile Leu Lys Glu Glu Phe Ser Ala Glu Glu Asn Phe Leu Ile Leu Thr 
        275                 280                 285             


Glu Met Ala Thr Asn His Val Gln Val Leu Val Glu Phe Thr Lys Lys 
    290                 295                 300                 


Leu Pro Gly Phe Gln Thr Leu Asp His Glu Asp Gln Ile Ala Leu Leu 
305                 310                 315                 320 


Lys Gly Ser Ala Val Glu Ala Met Phe Leu Arg Ser Ala Glu Ile Phe 
                325                 330                 335     


Asn Lys Lys Leu Pro Ser Gly His Ser Asp Leu Leu Glu Glu Arg Ile 
            340                 345                 350         


Arg Asn Ser Gly Ile Ser Asp Glu Tyr Ile Thr Pro Met Phe Ser Phe 
        355                 360                 365             


Tyr Lys Ser Ile Gly Glu Leu Lys Met Thr Gln Glu Glu Tyr Ala Leu 
    370                 375                 380                 


Leu Thr Ala Ile Val Ile Leu Ser Pro Asp Arg Gln Tyr Ile Lys Asp 
385                 390                 395                 400 


Arg Glu Ala Val Glu Lys Leu Gln Glu Pro Leu Leu Asp Val Leu Gln 
                405                 410                 415     


Lys Leu Cys Lys Ile His Gln Pro Glu Asn Pro Gln His Phe Ala Cys 
            420                 425                 430         


Leu Leu Gly Arg Leu Thr Glu Leu Arg Thr Phe Asn His His His Ala 
        435                 440                 445             


Glu Met Leu Met Ser Trp Arg Val Asn Asp His Lys Phe Thr Pro Leu 
    450                 455                 460                 


Leu Cys Glu Ile Trp Asp Val Gln 
465                 470         


<210>  202
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  202

Lys Ser Cys Arg Glu Lys Thr Glu Leu Thr Pro Asp Gln Gln Thr Leu 
1               5                   10                  15      


Leu His Phe Ile Met Asp Ser Tyr Asn Lys Gln Arg Met Pro Gln Glu 
            20                  25                  30          


Ile Thr Asn Lys Ile Leu Lys Glu Glu Phe Ser Ala Glu Glu Asn Phe 
        35                  40                  45              


Leu Ile Leu Thr Glu Met Ala Thr Asn His Val Gln Val Leu Val Glu 
    50                  55                  60                  


Phe Thr Lys Lys Leu Pro Gly Phe Gln Thr Leu Asp His Glu Asp Gln 
65                  70                  75                  80  


Ile Ala Leu Leu Lys Gly Ser Ala Val Glu Ala Met Phe Leu Arg Ser 
                85                  90                  95      


Ala Glu Ile Phe Asn Lys Lys Leu Pro Ser Gly His Ser Asp Leu Leu 
            100                 105                 110         


Glu Glu Arg Ile Arg Asn Ser Gly Ile Ser Asp Glu Tyr Ile Thr Pro 
        115                 120                 125             


Met Phe Ser Phe Tyr Lys Ser Ile Gly Glu Leu Lys Met Thr Gln Glu 
    130                 135                 140                 


Glu Tyr Ala Leu Leu Thr Ala Ile Val Ile Leu Ser Pro Asp Arg Gln 
145                 150                 155                 160 


Tyr Ile Lys Asp Arg Glu Ala Val Glu Lys Leu Gln Glu Pro Leu Leu 
                165                 170                 175     


Asp Val Leu Gln Lys Leu Cys Lys Ile His Gln Pro Glu Asn Pro Gln 
            180                 185                 190         


His Phe Ala Cys Leu Leu Gly Arg Leu Thr Glu Leu Arg Thr Phe Asn 
        195                 200                 205             


His His His Ala Glu Met Leu Met Ser Trp Arg Val Asn Asp His Lys 
    210                 215                 220                 


Phe Thr Pro Leu Leu Cys Glu Ile Trp Asp Val Gln 
225                 230                 235     


<210>  203
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Ser Leu Trp Leu Gly Ala Pro Val Pro Asp Ile Pro Pro Asp Ser 
1               5                   10                  15      


Ala Val Glu Leu Trp Lys Pro Gly Ala Gln Asp Ala Ser Ser Gln Ala 
            20                  25                  30          


Gln Gly Gly Ser Ser Cys Ile Leu Arg Glu Glu Ala Arg Met Pro His 
        35                  40                  45              


Ser Ala Gly Gly Thr Ala Gly Val Gly Leu Glu Ala Ala Glu Pro Thr 
    50                  55                  60                  


Ala Leu Leu Thr Arg Ala Glu Pro Pro Ser Glu Pro Thr Glu Ile Arg 
65                  70                  75                  80  


Pro Gln Lys Arg Lys Lys Gly Pro Ala Pro Lys Met Leu Gly Asn Glu 
                85                  90                  95      


Leu Cys Ser Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Asn Val 
            100                 105                 110         


Leu Ser Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Ser Val Ile Lys 
        115                 120                 125             


Gly Ala His Tyr Ile Cys His Ser Gly Gly His Cys Pro Met Asp Thr 
    130                 135                 140                 


Tyr Met Arg Arg Lys Cys Gln Glu Cys Arg Leu Arg Lys Cys Arg Gln 
145                 150                 155                 160 


Ala Gly Met Arg Glu Glu Cys Val Leu Ser Glu Glu Gln Ile Arg Leu 
                165                 170                 175     


Lys Lys Leu Lys Arg Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu 
            180                 185                 190         


Pro Pro Arg Ala Ser Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro 
        195                 200                 205             


Glu Gln Leu Gly Met Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys 
    210                 215                 220                 


Asn Arg Arg Ser Phe Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Met 
225                 230                 235                 240 


Ala Pro Asp Pro His Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His 
                245                 250                 255     


Phe Thr Glu Leu Ala Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala 
            260                 265                 270         


Lys Gln Leu Pro Gly Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala 
        275                 280                 285             


Leu Leu Lys Thr Ser Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg 
    290                 295                 300                 


Arg Tyr Asn Pro Gly Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser 
305                 310                 315                 320 


Tyr Asn Arg Glu Asp Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile 
                325                 330                 335     


Asn Pro Ile Phe Glu Phe Ser Arg Ala Met Asn Glu Leu Gln Leu Asn 
            340                 345                 350         


Asp Ala Glu Phe Ala Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp 
        355                 360                 365             


Arg Pro Asn Val Gln Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr 
    370                 375                 380                 


Tyr Val Glu Ala Leu His Ala Tyr Val Ser Ile His His Pro His Asp 
385                 390                 395                 400 


Arg Leu Met Phe Pro Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr 
                405                 410                 415     


Leu Ser Ser Val His Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp 
            420                 425                 430         


Lys Lys Leu Pro Pro Leu Leu Ser Glu Ile Trp Asp Val His Glu 
        435                 440                 445         


<210>  204
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  204

Gln Glu Glu Glu Gln Ala His Ala Thr Ser Leu Pro Pro Arg Ala Ser 
1               5                   10                  15      


Ser Pro Pro Gln Ile Leu Pro Gln Leu Ser Pro Glu Gln Leu Gly Met 
            20                  25                  30          


Ile Glu Lys Leu Val Ala Ala Gln Gln Gln Cys Asn Arg Arg Ser Phe 
        35                  40                  45              


Ser Asp Arg Leu Arg Val Thr Pro Trp Pro Met Ala Pro Asp Pro His 
    50                  55                  60                  


Ser Arg Glu Ala Arg Gln Gln Arg Phe Ala His Phe Thr Glu Leu Ala 
65                  70                  75                  80  


Ile Val Ser Val Gln Glu Ile Val Asp Phe Ala Lys Gln Leu Pro Gly 
                85                  90                  95      


Phe Leu Gln Leu Ser Arg Glu Asp Gln Ile Ala Leu Leu Lys Thr Ser 
            100                 105                 110         


Ala Ile Glu Val Met Leu Leu Glu Thr Ser Arg Arg Tyr Asn Pro Gly 
        115                 120                 125             


Ser Glu Ser Ile Thr Phe Leu Lys Asp Phe Ser Tyr Asn Arg Glu Asp 
    130                 135                 140                 


Phe Ala Lys Ala Gly Leu Gln Val Glu Phe Ile Asn Pro Ile Phe Glu 
145                 150                 155                 160 


Phe Ser Arg Ala Met Asn Glu Leu Gln Leu Asn Asp Ala Glu Phe Ala 
                165                 170                 175     


Leu Leu Ile Ala Ile Ser Ile Phe Ser Ala Asp Arg Pro Asn Val Gln 
            180                 185                 190         


Asp Gln Leu Gln Val Glu Arg Leu Gln His Thr Tyr Val Glu Ala Leu 
        195                 200                 205             


His Ala Tyr Val Ser Ile His His Pro His Asp Arg Leu Met Phe Pro 
    210                 215                 220                 


Arg Met Leu Met Lys Leu Val Ser Leu Arg Thr Leu Ser Ser Val His 
225                 230                 235                 240 


Ser Glu Gln Val Phe Ala Leu Arg Leu Gln Asp Lys Lys Leu Pro Pro 
                245                 250                 255     


Leu Leu Ser Glu Ile Trp Asp Val His Glu 
            260                 265     


<210>  205
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Arg Thr Gln Ile Glu Val Ile Pro Cys Lys Ile Cys Gly Asp Lys 
1               5                   10                  15      


Ser Ser Gly Ile His Tyr Gly Val Ile Thr Cys Glu Gly Cys Lys Gly 
            20                  25                  30          


Phe Phe Arg Arg Ser Gln Arg Cys Asn Ala Ala Tyr Ser Cys Thr Arg 
        35                  40                  45              


Gln Gln Asn Cys Pro Ile Asp Arg Thr Ser Arg Asn Arg Cys Gln His 
    50                  55                  60                  


Cys Arg Leu Gln Lys Cys Leu Ala Leu Gly Met Ser Arg Asp Ala Val 
65                  70                  75                  80  


Lys Phe Gly Arg Met Ser Lys Lys Gln Arg Asp Ser Leu His Ala Glu 
                85                  90                  95      


Val Gln Lys Gln Leu Gln Gln Arg Gln Gln Gln Gln Gln Glu Pro Val 
            100                 105                 110         


Val Lys Thr Pro Pro Ala Gly Ala Gln Gly Ala Asp Thr Leu Thr Tyr 
        115                 120                 125             


Thr Leu Gly Leu Pro Asp Gly Gln Leu Pro Leu Gly Ser Ser Pro Asp 
    130                 135                 140                 


Leu Pro Glu Ala Ser Ala Cys Pro Pro Gly Leu Leu Lys Ala Ser Gly 
145                 150                 155                 160 


Ser Gly Pro Ser Tyr Ser Asn Asn Leu Ala Lys Ala Gly Leu Asn Gly 
                165                 170                 175     


Ala Ser Cys His Leu Glu Tyr Ser Pro Glu Arg Gly Lys Ala Glu Gly 
            180                 185                 190         


Arg Glu Ser Phe Tyr Ser Thr Gly Ser Gln Leu Thr Pro Asp Arg Cys 
        195                 200                 205             


Gly Leu Arg Phe Glu Glu His Arg His Pro Gly Leu Gly Glu Leu Gly 
    210                 215                 220                 


Gln Gly Pro Asp Ser Tyr Gly Ser Pro Ser Phe Arg Ser Thr Pro Glu 
225                 230                 235                 240 


Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His Leu Val Gln Ser Val 
                245                 250                 255     


Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg Leu Glu Asp Leu Leu 
            260                 265                 270         


Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu Val Thr Gly Tyr Gln 
        275                 280                 285             


Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala His His Leu Thr 
    290                 295                 300                 


Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg Leu Ser Gly Phe 
305                 310                 315                 320 


Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu Lys Ala Gly Ala 
                325                 330                 335     


Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr Asn Ala Asp Asn 
            340                 345                 350         


Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Met Glu Leu Phe Arg 
        355                 360                 365             


Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe Asp Phe Ser His 
    370                 375                 380                 


Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu Ile Ala Leu Tyr Thr 
385                 390                 395                 400 


Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly Leu Gln Glu Lys Arg 
                405                 410                 415     


Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu Ala Phe His His His 
            420                 425                 430         


Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala Lys Leu Pro Pro Lys 
        435                 440                 445             


Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu Arg Leu Gln Ile 
    450                 455                 460                 


Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala Phe Pro Pro Leu 
465                 470                 475                 480 


Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser Pro Val Gly Leu Ser 
                485                 490                 495     


Lys 
    


<210>  206
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  206

Ser Thr Pro Glu Ala Pro Tyr Ala Ser Leu Thr Glu Ile Glu His Leu 
1               5                   10                  15      


Val Gln Ser Val Cys Lys Ser Tyr Arg Glu Thr Cys Gln Leu Arg Leu 
            20                  25                  30          


Glu Asp Leu Leu Arg Gln Arg Ser Asn Ile Phe Ser Arg Glu Glu Val 
        35                  40                  45              


Thr Gly Tyr Gln Arg Lys Ser Met Trp Glu Met Trp Glu Arg Cys Ala 
    50                  55                  60                  


His His Leu Thr Glu Ala Ile Gln Tyr Val Val Glu Phe Ala Lys Arg 
65                  70                  75                  80  


Leu Ser Gly Phe Met Glu Leu Cys Gln Asn Asp Gln Ile Val Leu Leu 
                85                  90                  95      


Lys Ala Gly Ala Met Glu Val Val Leu Val Arg Met Cys Arg Ala Tyr 
            100                 105                 110         


Asn Ala Asp Asn Arg Thr Val Phe Phe Glu Gly Lys Tyr Gly Gly Met 
        115                 120                 125             


Glu Leu Phe Arg Ala Leu Gly Cys Ser Glu Leu Ile Ser Ser Ile Phe 
    130                 135                 140                 


Asp Phe Ser His Ser Leu Ser Ala Leu His Phe Ser Glu Asp Glu Ile 
145                 150                 155                 160 


Ala Leu Tyr Thr Ala Leu Val Leu Ile Asn Ala His Arg Pro Gly Leu 
                165                 170                 175     


Gln Glu Lys Arg Lys Val Glu Gln Leu Gln Tyr Asn Leu Glu Leu Ala 
            180                 185                 190         


Phe His His His Leu Cys Lys Thr His Arg Gln Ser Ile Leu Ala Lys 
        195                 200                 205             


Leu Pro Pro Lys Gly Lys Leu Arg Ser Leu Cys Ser Gln His Val Glu 
    210                 215                 220                 


Arg Leu Gln Ile Phe Gln His Leu His Pro Ile Val Val Gln Ala Ala 
225                 230                 235                 240 


Phe Pro Pro Leu Tyr Lys Glu Leu Phe Ser Thr Glu Thr Glu Ser Pro 
                245                 250                 255     


Val Gly Leu Ser Lys 
            260     


<210>  207
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Asp Thr Lys His Phe Leu Pro Leu Asp Phe Ser Thr Gln Val Asn 
1               5                   10                  15      


Ser Ser Leu Thr Ser Pro Thr Gly Arg Gly Ser Met Ala Ala Pro Ser 
            20                  25                  30          


Leu His Pro Ser Leu Gly Pro Gly Ile Gly Ser Pro Gly Gln Leu His 
        35                  40                  45              


Ser Pro Ile Ser Thr Leu Ser Ser Pro Ile Asn Gly Met Gly Pro Pro 
    50                  55                  60                  


Phe Ser Val Ile Ser Ser Pro Met Gly Pro His Ser Met Ser Val Pro 
65                  70                  75                  80  


Thr Thr Pro Thr Leu Gly Phe Ser Thr Gly Ser Pro Gln Leu Ser Ser 
                85                  90                  95      


Pro Met Asn Pro Val Ser Ser Ser Glu Asp Ile Lys Pro Pro Leu Gly 
            100                 105                 110         


Leu Asn Gly Val Leu Lys Val Pro Ala His Pro Ser Gly Asn Met Ala 
        115                 120                 125             


Ser Phe Thr Lys His Ile Cys Ala Ile Cys Gly Asp Arg Ser Ser Gly 
    130                 135                 140                 


Lys His Tyr Gly Val Tyr Ser Cys Glu Gly Cys Lys Gly Phe Phe Lys 
145                 150                 155                 160 


Arg Thr Val Arg Lys Asp Leu Thr Tyr Thr Cys Arg Asp Asn Lys Asp 
                165                 170                 175     


Cys Leu Ile Asp Lys Arg Gln Arg Asn Arg Cys Gln Tyr Cys Arg Tyr 
            180                 185                 190         


Gln Lys Cys Leu Ala Met Gly Met Lys Arg Glu Ala Val Gln Glu Glu 
        195                 200                 205             


Arg Gln Arg Gly Lys Asp Arg Asn Glu Asn Glu Val Glu Ser Thr Ser 
    210                 215                 220                 


Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
225                 230                 235                 240 


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
                245                 250                 255     


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
            260                 265                 270         


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
        275                 280                 285             


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
    290                 295                 300                 


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
305                 310                 315                 320 


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
                325                 330                 335     


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
            340                 345                 350         


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
        355                 360                 365             


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
    370                 375                 380                 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
385                 390                 395                 400 


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
                405                 410                 415     


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
            420                 425                 430         


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
        435                 440                 445             


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
    450                 455                 460         


<210>  208
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  208

Ser Ala Asn Glu Asp Met Pro Val Glu Arg Ile Leu Glu Ala Glu Leu 
1               5                   10                  15      


Ala Val Glu Pro Lys Thr Glu Thr Tyr Val Glu Ala Asn Met Gly Leu 
            20                  25                  30          


Asn Pro Ser Ser Pro Asn Asp Pro Val Thr Asn Ile Cys Gln Ala Ala 
        35                  40                  45              


Asp Lys Gln Leu Phe Thr Leu Val Glu Trp Ala Lys Arg Ile Pro His 
    50                  55                  60                  


Phe Ser Glu Leu Pro Leu Asp Asp Gln Val Ile Leu Leu Arg Ala Gly 
65                  70                  75                  80  


Trp Asn Glu Leu Leu Ile Ala Ser Phe Ser His Arg Ser Ile Ala Val 
                85                  90                  95      


Lys Asp Gly Ile Leu Leu Ala Thr Gly Leu His Val His Arg Asn Ser 
            100                 105                 110         


Ala His Ser Ala Gly Val Gly Ala Ile Phe Asp Arg Val Leu Thr Glu 
        115                 120                 125             


Leu Val Ser Lys Met Arg Asp Met Gln Met Asp Lys Thr Glu Leu Gly 
    130                 135                 140                 


Cys Leu Arg Ala Ile Val Leu Phe Asn Pro Asp Ser Lys Gly Leu Ser 
145                 150                 155                 160 


Asn Pro Ala Glu Val Glu Ala Leu Arg Glu Lys Val Tyr Ala Ser Leu 
                165                 170                 175     


Glu Ala Tyr Cys Lys His Lys Tyr Pro Glu Gln Pro Gly Arg Phe Ala 
            180                 185                 190         


Lys Leu Leu Leu Arg Leu Pro Ala Leu Arg Ser Ile Gly Leu Lys Cys 
        195                 200                 205             


Leu Glu His Leu Phe Phe Phe Lys Leu Ile Gly Asp Thr Pro Ile Asp 
    210                 215                 220                 


Thr Phe Leu Met Glu Met Leu Glu Ala Pro His Gln Met Thr 
225                 230                 235             


<210>  209
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Glu Val Arg Pro Lys Glu Ser Trp Asn His Ala Asp Phe Val His 
1               5                   10                  15      


Cys Glu Asp Thr Glu Ser Val Pro Gly Lys Pro Ser Val Asn Ala Asp 
            20                  25                  30          


Glu Glu Val Gly Gly Pro Gln Ile Cys Arg Val Cys Gly Asp Lys Ala 
        35                  40                  45              


Thr Gly Tyr His Phe Asn Val Met Thr Cys Glu Gly Cys Lys Gly Phe 
    50                  55                  60                  


Phe Arg Arg Ala Met Lys Arg Asn Ala Arg Leu Arg Cys Pro Phe Arg 
65                  70                  75                  80  


Lys Gly Ala Cys Glu Ile Thr Arg Lys Thr Arg Arg Gln Cys Gln Ala 
                85                  90                  95      


Cys Arg Leu Arg Lys Cys Leu Glu Ser Gly Met Lys Lys Glu Met Ile 
            100                 105                 110         


Met Ser Asp Glu Ala Val Glu Glu Arg Arg Ala Leu Ile Lys Arg Lys 
        115                 120                 125             


Lys Ser Glu Arg Thr Gly Thr Gln Pro Leu Gly Val Gln Gly Leu Thr 
    130                 135                 140                 


Glu Glu Gln Arg Met Met Ile Arg Glu Leu Met Asp Ala Gln Met Lys 
145                 150                 155                 160 


Thr Phe Asp Thr Thr Phe Ser His Phe Lys Asn Phe Arg Leu Pro Gly 
                165                 170                 175     


Val Leu Ser Ser Gly Cys Glu Leu Pro Glu Ser Leu Gln Ala Pro Ser 
            180                 185                 190         


Arg Glu Glu Ala Ala Lys Trp Ser Gln Val Arg Lys Asp Leu Cys Ser 
        195                 200                 205             


Leu Lys Val Ser Leu Gln Leu Arg Gly Glu Asp Gly Ser Val Trp Asn 
    210                 215                 220                 


Tyr Lys Pro Pro Ala Asp Ser Gly Gly Lys Glu Ile Phe Ser Leu Leu 
225                 230                 235                 240 


Pro His Met Ala Asp Met Ser Thr Tyr Met Phe Lys Gly Ile Ile Ser 
                245                 250                 255     


Phe Ala Lys Val Ile Ser Tyr Phe Arg Asp Leu Pro Ile Glu Asp Gln 
            260                 265                 270         


Ile Ser Leu Leu Lys Gly Ala Ala Phe Glu Leu Cys Gln Leu Arg Phe 
        275                 280                 285             


Asn Thr Val Phe Asn Ala Glu Thr Gly Thr Trp Glu Cys Gly Arg Leu 
    290                 295                 300                 


Ser Tyr Cys Leu Glu Asp Thr Ala Gly Gly Phe Gln Gln Leu Leu Leu 
305                 310                 315                 320 


Glu Pro Met Leu Lys Phe His Tyr Met Leu Lys Lys Leu Gln Leu His 
                325                 330                 335     


Glu Glu Glu Tyr Val Leu Met Gln Ala Ile Ser Leu Phe Ser Pro Asp 
            340                 345                 350         


Arg Pro Gly Val Leu Gln His Arg Val Val Asp Gln Leu Gln Glu Gln 
        355                 360                 365             


Phe Ala Ile Thr Leu Lys Ser Tyr Ile Glu Cys Asn Arg Pro Gln Pro 
    370                 375                 380                 


Ala His Arg Phe Leu Phe Leu Lys Ile Met Ala Met Leu Thr Glu Leu 
385                 390                 395                 400 


Arg Ser Ile Asn Ala Gln His Thr Gln Arg Leu Leu Arg Ile Gln Asp 
                405                 410                 415     


Ile His Pro Phe Ala Thr Pro Leu Met Gln Glu Leu Phe Gly Ile Thr 
            420                 425                 430         


Gly Ser 
        


<210>  210
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  210

Ser Glu Arg Thr Gly Thr Gln Pro Leu Gly Val Gln Gly Leu Thr Glu 
1               5                   10                  15      


Glu Gln Arg Met Met Ile Arg Glu Leu Met Asp Ala Gln Met Lys Thr 
            20                  25                  30          


Phe Asp Thr Thr Phe Ser His Phe Lys Asn Phe Arg Leu Pro Gly Val 
        35                  40                  45              


Leu Ser Ser Gly Cys Glu Leu Pro Glu Ser Leu Gln Ala Pro Ser Arg 
    50                  55                  60                  


Glu Glu Ala Ala Lys Trp Ser Gln Val Arg Lys Asp Leu Cys Ser Leu 
65                  70                  75                  80  


Lys Val Ser Leu Gln Leu Arg Gly Glu Asp Gly Ser Val Trp Asn Tyr 
                85                  90                  95      


Lys Pro Pro Ala Asp Ser Gly Gly Lys Glu Ile Phe Ser Leu Leu Pro 
            100                 105                 110         


His Met Ala Asp Met Ser Thr Tyr Met Phe Lys Gly Ile Ile Ser Phe 
        115                 120                 125             


Ala Lys Val Ile Ser Tyr Phe Arg Asp Leu Pro Ile Glu Asp Gln Ile 
    130                 135                 140                 


Ser Leu Leu Lys Gly Ala Ala Phe Glu Leu Cys Gln Leu Arg Phe Asn 
145                 150                 155                 160 


Thr Val Phe Asn Ala Glu Thr Gly Thr Trp Glu Cys Gly Arg Leu Ser 
                165                 170                 175     


Tyr Cys Leu Glu Asp Thr Ala Gly Gly Phe Gln Gln Leu Leu Leu Glu 
            180                 185                 190         


Pro Met Leu Lys Phe His Tyr Met Leu Lys Lys Leu Gln Leu His Glu 
        195                 200                 205             


Glu Glu Tyr Val Leu Met Gln Ala Ile Ser Leu Phe Ser Pro Asp Arg 
    210                 215                 220                 


Pro Gly Val Leu Gln His Arg Val Val Asp Gln Leu Gln Glu Gln Phe 
225                 230                 235                 240 


Ala Ile Thr Leu Lys Ser Tyr Ile Glu Cys Asn Arg Pro Gln Pro Ala 
                245                 250                 255     


His Arg Phe Leu Phe Leu Lys Ile Met Ala Met Leu Thr Glu Leu Arg 
            260                 265                 270         


Ser Ile Asn Ala Gln His Thr Gln Arg Leu Leu Arg Ile Gln Asp Ile 
        275                 280                 285             


His Pro Phe Ala Thr Pro Leu Met Gln Glu Leu Phe Gly Ile Thr Gly 
    290                 295                 300                 


Ser 
305 


<210>  211
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  211

Arg Cys Arg Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val 
1               5                   10                  15      


Arg Pro Val 
            


<210>  212
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  212

Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly Ile Gln Asp Thr 
1               5                   10                  15      


Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu Thr 
            20                  25                  


<210>  213
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  213

Lys Lys Arg His Met Ala Ser Tyr Ser Met Cys Ser Asp Pro Ser Thr 
1               5                   10                  15      


Arg Asp Pro Pro Gly Arg Pro Glu Pro Tyr Val Glu Val Tyr Leu Ile 
            20                  25                  30          


<210>  214
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  214

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  215
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  215

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val 
        35  


<210>  216
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  216

Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr Gly Val 
1               5                   10                  15      


Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu Lys Gln Phe Gln 
            20                  25                  30          


Pro Tyr Phe Ile Pro Ile Asn 
        35                  


<210>  217
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  217

Ala Arg Thr Gln Ile Lys Lys Leu Cys Ser Trp Arg Asp Lys Asn Ser 
1               5                   10                  15      


Ala Ala Cys Val Val Tyr Glu Asp Met Ser His Ser Arg Cys Asn Thr 
            20                  25                  30          


Leu Ser Ser Pro Asn Gln Tyr Gln 
        35                  40  


<210>  218
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  218

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  219
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  219

Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
1               5                   10                  15      


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
            20                  25                  30          


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40              


<210>  220
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  220

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  221
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  221

Arg Arg Gln Trp Arg Pro Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile 
1               5                   10                  15      


His Pro Pro Gln Ala Gln Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro 
            20                  25                  30          


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
        35                  40                  45              


Glu Gln Leu 
    50      


<210>  222
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  222

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  223
<211>  61
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  223

Asn Arg Arg Arg Arg Arg Glu Arg Arg Asp Leu Phe Thr Glu Ser Trp 
1               5                   10                  15      


Asp Thr Gln Lys Ala Pro Asn Asn Tyr Arg Ser Pro Ile Ser Thr Ser 
            20                  25                  30          


Gln Pro Thr Asn Gln Ser Met Asp Asp Thr Arg Glu Asp Ile Tyr Val 
        35                  40                  45              


Asn Tyr Pro Thr Phe Ser Arg Arg Pro Lys Thr Arg Val 
    50                  55                  60      


<210>  224
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  224

Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln 
1               5                   10                  15      


Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr 
            20                  25                  30          


Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln 
        35                  40                  45              


Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
    50                  55                  60          


<210>  225
<211>  77
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  225

Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
1               5                   10                  15      


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
            20                  25                  30          


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
        35                  40                  45              


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
    50                  55                  60                  


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
65                  70                  75          


<210>  226
<211>  80
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  226

Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu Gly Asp Leu Arg 
1               5                   10                  15      


Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser Ala Pro Ser Pro 
            20                  25                  30          


Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala Gly Leu Cys Gly 
        35                  40                  45              


Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp Tyr Phe Asn Val 
    50                  55                  60                  


Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe Thr Glu Thr Gly 
65                  70                  75                  80  


<210>  227
<211>  83
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  227

Lys Leu Arg Lys Ala His Val Ile Trp Lys Lys Glu Asn Glu Val Ser 
1               5                   10                  15      


Glu His Thr Leu Glu Ser Tyr Arg Ser Arg Ser Asn Asn Glu Glu Thr 
            20                  25                  30          


Ser Ser Glu Glu Lys Asn Gly Gln Ser Ser His Pro Met Arg Cys Met 
        35                  40                  45              


Asn Tyr Ile Thr Lys Leu Tyr Ser Glu Ala Lys Thr Lys Arg Lys Glu 
    50                  55                  60                  


Asn Val Gln His Ser Lys Leu Glu Glu Lys His Ile Gln Val Pro Glu 
65                  70                  75                  80  


Ser Ile Val 
            


<210>  228
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  228

Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly 
1               5                   10                  15      


Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp 
            20                  25                  30          


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
        35                  40                  45              


Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
    50                  55                  60                  


Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly 
65                  70                  75                  80  


Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp 
                85                  90                  95      


Pro Leu 
        


<210>  229
<211>  101
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  229

His Arg Gln Asn Gln Ile Lys Gln Gly Pro Pro Arg Ser Lys Asp Glu 
1               5                   10                  15      


Glu Gln Lys Pro Gln Gln Arg Pro Asp Leu Ala Val Asp Val Leu Glu 
            20                  25                  30          


Arg Thr Ala Asp Lys Ala Thr Val Asn Gly Leu Pro Glu Lys Asp Arg 
        35                  40                  45              


Glu Thr Asp Thr Ser Ala Leu Ala Ala Gly Ser Ser Gln Glu Val Thr 
    50                  55                  60                  


Tyr Ala Gln Leu Asp His Trp Ala Leu Thr Gln Arg Thr Ala Arg Ala 
65                  70                  75                  80  


Val Ser Pro Gln Ser Thr Lys Pro Met Ala Glu Ser Ile Thr Tyr Ala 
                85                  90                  95      


Ala Val Ala Arg His 
            100     


<210>  230
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  230

Cys Cys Arg Lys Lys Arg Arg Glu Glu Lys Tyr Glu Lys Glu Val His 
1               5                   10                  15      


His Asp Ile Arg Glu Asp Val Pro Pro Pro Lys Ser Arg Thr Ser Thr 
            20                  25                  30          


Ala Arg Ser Tyr Ile Gly Ser Asn His Ser Ser Leu Gly Ser Met Ser 
        35                  40                  45              


Pro Ser Asn Met Glu Gly Tyr Ser Lys Thr Gln Tyr Asn Gln Val Pro 
    50                  55                  60                  


Ser Glu Asp Phe Glu Arg Thr Pro Gln Ser Pro Thr Leu Pro Pro Ala 
65                  70                  75                  80  


Lys Val Ala Ala Pro Asn Leu Ser Arg Met Gly Ala Ile Pro Val Met 
                85                  90                  95      


Ile Pro Ala Gln Ser Lys Asp Gly Ser Ile Val 
            100                 105         


<210>  231
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  231

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  232
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  232

Thr Lys Arg Lys Lys Gln Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu 
1               5                   10                  15      


Thr Arg Ala His Arg Val Ala Thr Glu Glu Arg Gly Arg Lys Pro His 
            20                  25                  30          


Gln Ile Pro Ala Ser Thr Pro Gln Asn Pro Ala Thr Ser Gln His Pro 
        35                  40                  45              


Pro Pro Pro Pro Gly His Arg Ser Gln Ala Pro Ser His Arg Pro Pro 
    50                  55                  60                  


Pro Pro Gly His Arg Val Gln His Gln Pro Gln Lys Arg Pro Pro Ala 
65                  70                  75                  80  


Pro Ser Gly Thr Gln Val His Gln Gln Lys Gly Pro Pro Leu Pro Arg 
                85                  90                  95      


Pro Arg Val Gln Pro Lys Pro Pro His Gly Ala Ala Glu Asn Ser Leu 
            100                 105                 110         


Ser Pro Ser Ser Asn 
        115         


<210>  233
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  233

Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu 
1               5                   10                  15      


Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn 
            20                  25                  30          


His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser 
        35                  40                  45              


Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr 
    50                  55                  60                  


Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys 
65                  70                  75                  80  


Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly 
                85                  90                  95      


Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu 
            100                 105                 110         


Leu Glu Asn Phe Asp Val Tyr Ser 
        115                 120 


<210>  234
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  234

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  235
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  235

Thr Tyr Arg His Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu 
1               5                   10                  15      


Ala Gly Met Glu Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro 
            20                  25                  30          


Leu Asp Ser Ala His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys 
        35                  40                  45              


Ile Cys Thr Val Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro 
    50                  55                  60                  


Glu Thr Gln Glu Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln 
65                  70                  75                  80  


Leu Pro Ser Arg Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro 
                85                  90                  95      


Glu Ser Pro Ala Gly Ser Pro Ala Met Met Leu Gln 
            100                 105             


<210>  236
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  236

Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His 
1               5                   10                  15      


Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln 
            20                  25                  30          


Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
        35                  40          


<210>  237
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  237

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser 
    50      


<210>  238
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  238

Lys Lys Tyr Phe Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe 
1               5                   10                  15      


Ser Ser Leu Gln Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val 
            20                  25                  30          


Gln Ala Glu Asp Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        35                  40                  45              


<210>  239
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  239

Ser Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu 
1               5                   10                  15      


Val Ala Leu Gln Ala Leu 
            20          


<210>  240
<211>  85
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  240

Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser Ser Ala Glu 
1               5                   10                  15      


Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp Lys Val Ile 
            20                  25                  30          


Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala Trp Pro Pro 
        35                  40                  45              


Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser Val Pro Val 
    50                  55                  60                  


Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala 
65                  70                  75                  80  


Gly Pro Glu Gln Gln 
                85  


<210>  241
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  241

Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro Cys Ser Cys Gln Pro Arg 
1               5                   10                  15      


Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser Ser Gln Asp His Ala Met 
            20                  25                  30          


Glu Ala Gly Ser Pro Val Ser Thr Ser Pro Glu Pro Val Glu Thr Cys 
        35                  40                  45              


Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro Thr Gln Glu Ser Ala Val 
    50                  55                  60                  


Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala Gly Arg Trp Gly Cys His 
65                  70                  75                  80  


Thr Arg Thr Thr Val Leu Gln Pro Cys Pro His Ile Pro Asp Ser Gly 
                85                  90                  95      


Leu Gly Ile Val Cys Val Pro Ala Gln Glu Gly Gly Pro Gly Ala 
            100                 105                 110     


<210>  242
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  242

Met Ala Glu Ala Ile Thr Tyr Ala Asp Leu Arg Phe Val Lys Ala Pro 
1               5                   10                  15      


Leu Lys Lys Ser Ile Ser Ser Arg Leu Gly Gln Asp Pro Gly Ala Asp 
            20                  25                  30          


Asp Asp Gly Glu Ile Thr Tyr Glu Asn Val Gln Val Pro Ala Val Leu 
        35                  40                  45              


Gly Val Pro Ser Ser Leu Ala Ser Ser Val Leu Gly Asp Lys Ala Ala 
    50                  55                  60                  


Val Lys Ser Glu Gln Pro Thr Ala Ser Trp Arg Ala Val Thr Ser Pro 
65                  70                  75                  80  


Ala Val Gly Arg Ile Leu Pro Cys Arg Thr Thr Cys Leu Arg Tyr 
                85                  90                  95  


<210>  243
<211>  141
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  243

Lys Leu Gln Arg Arg Trp Lys Arg Thr Gln Ser Gln Gln Gly Leu Gln 
1               5                   10                  15      


Glu Asn Ser Ser Gly Gln Ser Phe Phe Val Arg Asn Lys Lys Val Arg 
            20                  25                  30          


Arg Ala Pro Leu Ser Glu Gly Pro His Ser Leu Gly Cys Tyr Asn Pro 
        35                  40                  45              


Met Met Glu Asp Gly Ile Ser Tyr Thr Thr Leu Arg Phe Pro Glu Met 
    50                  55                  60                  


Asn Ile Pro Arg Thr Gly Asp Ala Glu Ser Ser Glu Met Gln Arg Pro 
65                  70                  75                  80  


Pro Pro Asp Cys Asp Asp Thr Val Thr Tyr Ser Ala Leu His Lys Arg 
                85                  90                  95      


Gln Val Gly Asp Tyr Glu Asn Val Ile Pro Asp Phe Pro Glu Asp Glu 
            100                 105                 110         


Gly Ile His Tyr Ser Glu Leu Ile Gln Phe Gly Val Gly Glu Arg Pro 
        115                 120                 125             


Gln Ala Gln Glu Asn Val Asp Tyr Val Ile Leu Lys His 
    130                 135                 140     


<210>  244
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  244

Arg Lys Trp Cys Gln Tyr Gln Lys Glu Ile Met Glu Arg Pro Pro Pro 
1               5                   10                  15      


Phe Lys Pro Pro Pro Pro Pro Ile Lys Tyr Thr Cys Ile Gln Glu Pro 
            20                  25                  30          


Asn Glu Ser Asp Leu Pro Tyr His Glu Met Glu Thr Leu 
        35                  40                  45  


<210>  245
<211>  84
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  245

Leu Arg Lys Arg Arg Asp Ser Leu Ser Leu Ser Thr Gln Arg Thr Gln 
1               5                   10                  15      


Gly Pro Ala Glu Ser Ala Arg Asn Leu Glu Tyr Val Ser Val Ser Pro 
            20                  25                  30          


Thr Asn Asn Thr Val Tyr Ala Ser Val Thr His Ser Asn Arg Glu Thr 
        35                  40                  45              


Glu Ile Trp Thr Pro Arg Glu Asn Asp Thr Ile Thr Ile Tyr Ser Thr 
    50                  55                  60                  


Ile Asn His Ser Lys Glu Ser Lys Pro Thr Phe Ser Arg Ala Thr Ala 
65                  70                  75                  80  


Leu Asp Asn Val 
                


<210>  246
<211>  88
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  246

Trp Phe Leu Lys Arg Glu Arg Gln Glu Glu Tyr Ile Glu Glu Lys Lys 
1               5                   10                  15      


Arg Val Asp Ile Cys Arg Glu Thr Pro Asn Ile Cys Pro His Ser Gly 
            20                  25                  30          


Glu Asn Thr Glu Tyr Asp Thr Ile Pro His Thr Asn Arg Thr Ile Leu 
        35                  40                  45              


Lys Glu Asp Pro Ala Asn Thr Val Tyr Ser Thr Val Glu Ile Pro Lys 
    50                  55                  60                  


Lys Met Glu Asn Pro His Ser Leu Leu Thr Met Pro Asp Thr Pro Arg 
65                  70                  75                  80  


Leu Phe Ala Tyr Glu Asn Val Ile 
                85              


<210>  247
<211>  82
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  247

Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala Val Gly Arg Asn Asp 
1               5                   10                  15      


Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys His Gln Lys Lys Ser 
            20                  25                  30          


Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro 
        35                  40                  45              


Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala Ser Leu Asn Phe His 
    50                  55                  60                  


Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg 
65                  70                  75                  80  


Thr Gln 
        


<210>  248
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  248

Met Thr Asp Ser Val Ile Tyr Ser Met Leu Glu Leu Pro Thr Ala Thr 
1               5                   10                  15      


Gln Ala Gln Asn Asp Tyr Gly Pro Gln Gln Lys Ser Ser Ser Ser Arg 
            20                  25                  30          


Pro Ser Cys Ser Cys Leu 
        35              


<210>  249
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  249

Met Asp Gln Gln Ala Ile Tyr Ala Glu Leu Asn Leu Pro Thr Asp Ser 
1               5                   10                  15      


Gly Pro Glu Ser Ser Ser Pro Ser Ser Leu Pro Arg Asp Val Cys Gln 
            20                  25                  30          


Gly Ser Pro Trp His Gln Phe Ala Leu Lys Leu Ser Cys 
        35                  40                  45  


<210>  250
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  250

Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
145                 150                 155                 160 


Ile Tyr Ala Thr Leu Ala Ile His 
                165             


<210>  251
<211>  83
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  251

Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Ser 
1               5                   10                  15      


Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp Glu Gln Asp Pro 
            20                  25                  30          


Gln Glu Val Thr Tyr Thr Gln Leu Asn His Cys Val Phe Thr Gln Arg 
        35                  40                  45              


Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp Ile 
    50                  55                  60                  


Ile Val Tyr Thr Glu Leu Pro Asn Ala Glu Ser Arg Ser Lys Val Val 
65                  70                  75                  80  


Ser Cys Pro 
            


<210>  252
<211>  84
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  252

His Leu Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu 
1               5                   10                  15      


Pro Ala Gly Asn Arg Thr Ala Asn Ser Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


Pro Glu Glu Val Thr Tyr Ala Gln Leu Asp His Cys Val Phe Thr Gln 
        35                  40                  45              


Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr Pro Pro Thr Asp 
    50                  55                  60                  


Thr Ile Leu Tyr Thr Glu Leu Pro Asn Ala Lys Pro Arg Ser Lys Val 
65                  70                  75                  80  


Val Ser Cys Pro 
                


<210>  253
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  253

Met Ala Val Phe Lys Thr Thr Leu Trp Arg 
1               5                   10  


<210>  254
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  254

Lys Gly Ser Gln Arg Val Pro Glu Glu Pro Gly Glu Gln Pro Ile Tyr 
1               5                   10                  15      


Met Asn Phe Ser Glu Pro Leu Thr Lys Asp Met Ala Thr 
            20                  25                  


<210>  255
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  255

Val Asn Arg Pro Gln Trp Ala Pro Pro Gly Arg 
1               5                   10      


<210>  256
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  256

Val Thr Leu Arg Ser Phe Val Pro 
1               5               


<210>  257
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  257

Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro Ser Glu Leu 
1               5                   10                  15      


Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu Pro Gly Leu 
            20                  25                  30          


Arg Asp Thr 
        35  


<210>  258
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  258

Gln His Ser Gln Arg Ser Pro Pro Arg Cys Ser Gln Glu Ala Asn Ser 
1               5                   10                  15      


Arg Lys Asp Asn Ala Pro Phe Arg Val Val Glu Pro Trp Glu Gln Ile 
            20                  25                  30          


<210>  259
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  259

Gln His Trp Arg Gln Gly Lys His Arg Thr Leu Ala Gln Arg Gln Ala 
1               5                   10                  15      


Asp Phe Gln Arg Pro Pro Gly Ala Ala Glu Pro Glu Pro Lys Asp Gly 
            20                  25                  30          


Gly Leu Gln Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Gly Glu Asn 
        35                  40                  45              


Phe Cys Ala Ala Val Lys Asn Thr Gln Pro Glu Asp Gly Val Glu Met 
    50                  55                  60                  


Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Lys Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Phe Thr Leu Arg Gln Lys Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Ala Ser Pro Ala Glu Pro Ser 
145                 150                 155                 160 


Val Tyr Ala Thr Leu Ala Ile His 
                165             


<210>  260
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  260

Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
65                  70                  75                  80  


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro 
                85                  90                  95      


Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Thr 
            100                 105                 110         


Leu Ala Ile His 
        115     


<210>  261
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  261

Met Ala Lys Arg Lys Gln Gly Asn Arg Leu Gly Val Cys Gly Arg Phe 
1               5                   10                  15      


Leu Ser Ser Arg Val Ser Gly Met Asn Pro Ser Ser Val Val His His 
            20                  25                  30          


Val Ser Asp Ser Gly Pro Ala Ala Glu Leu Pro Leu Asp Val Pro His 
        35                  40                  45              


Ile Arg Leu Asp Ser Pro Pro Ser Phe Asp Asn Thr Thr Tyr Thr Ser 
    50                  55                  60                  


Leu Pro Leu Asp Ser Pro Ser Gly Lys Pro Ser Leu Pro Ala Pro Ser 
65                  70                  75                  80  


Ser Leu Pro Pro Leu Pro Pro Lys Val Leu Val Cys Ser Lys Pro Val 
                85                  90                  95      


Thr Tyr Ala Thr Val Ile Phe Pro Gly Gly Asn Lys Gly Gly Gly Thr 
            100                 105                 110         


Ser Cys Gly Pro Ala Gln Asn Pro Pro Asn Asn Gln Thr Pro Ser Ser 
        115                 120                 125             


<210>  262
<211>  61
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  262

Lys Val Asn Gly Cys Arg Lys Tyr Lys Leu Asn Lys Thr Glu Ser Thr 
1               5                   10                  15      


Pro Val Val Glu Glu Asp Glu Met Gln Pro Tyr Ala Ser Tyr Thr Glu 
            20                  25                  30          


Lys Asn Asn Pro Leu Tyr Asp Thr Thr Asn Lys Val Lys Ala Ser Glu 
        35                  40                  45              


Ala Leu Gln Ser Glu Val Asp Thr Asp Leu His Thr Leu 
    50                  55                  60      


<210>  263
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  263

Arg Met Phe Gln Lys Trp Ile Lys Ala Gly Asp His Ser Glu Leu Ser 
1               5                   10                  15      


Gln Asn Pro Lys Gln Ala Ala Thr Gln Ser Glu Leu His Tyr Ala Asn 
            20                  25                  30          


Leu Glu Leu Leu Met Trp Pro Leu Gln Glu Lys Pro Ala Pro Pro Arg 
        35                  40                  45              


Glu Val Glu Val Glu Tyr Ser Thr Val Ala Ser Pro Arg Glu Glu Leu 
    50                  55                  60                  


His Tyr Ala Ser Val Val Phe Asp Ser Asn Thr Asn Arg Ile Ala Ala 
65                  70                  75                  80  


Gln Arg Pro Arg Glu Glu Glu Pro Asp Ser Asp Tyr Ser Val Ile Arg 
                85                  90                  95      


Lys Thr 
        


<210>  264
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  264

Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro Glu 
1               5                   10                  15      


Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu Thr 
            20                  25                  30          


Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu Ser 
        35                  40                  45              


Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala Ser 
    50                  55                  60                  


Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala Glu 
65                  70                  75                  80  


Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His Leu 
                85                  90                  95      


Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser Arg 
            100                 105                 110         


Pro 
    


<210>  265
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  265

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys 
        35          


<210>  266
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  266

Arg Lys Ser Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys 
1               5                   10                  15      


Ser Asp Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
            20                  25                  


<210>  267
<211>  95
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  267

Leu Pro Lys Tyr Lys Thr Arg Lys Ala Met Arg Asn Asn Val Pro Arg 
1               5                   10                  15      


Asp Arg Gly Asp Thr Ala Met Glu Val Gly Ile Tyr Ala Asn Ile Leu 
            20                  25                  30          


Glu Lys Gln Ala Lys Glu Glu Ser Val Pro Glu Val Gly Ser Arg Pro 
        35                  40                  45              


Cys Val Ser Thr Ala Gln Asp Glu Ala Lys His Ser Gln Glu Leu Gln 
    50                  55                  60                  


Tyr Ala Thr Pro Val Phe Gln Glu Val Ala Pro Arg Glu Gln Glu Ala 
65                  70                  75                  80  


Cys Asp Ser Tyr Lys Ser Gly Tyr Val Tyr Ser Glu Leu Asn Phe 
                85                  90                  95  


<210>  268
<211>  178
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  268

Arg Arg Arg His Arg Gly Lys Phe Arg Lys Asp Val Gln Lys Glu Lys 
1               5                   10                  15      


Asp Leu Gln Leu Ser Ser Gly Ala Glu Glu Pro Ile Thr Arg Lys Gly 
            20                  25                  30          


Glu Leu Gln Lys Arg Pro Asn Pro Ala Ala Ala Thr Gln Glu Glu Ser 
        35                  40                  45              


Leu Tyr Ala Ser Val Glu Asp Met Gln Thr Glu Asp Gly Val Glu Leu 
    50                  55                  60                  


Asn Ser Trp Thr Pro Pro Glu Glu Asp Pro Gln Gly Glu Thr Tyr Ala 
65                  70                  75                  80  


Gln Val Lys Pro Ser Arg Leu Arg Lys Ala Gly His Val Ser Pro Ser 
                85                  90                  95      


Val Met Ser Arg Glu Gln Leu Asn Thr Glu Tyr Glu Gln Ala Glu Glu 
            100                 105                 110         


Gly Gln Gly Ala Asn Asn Gln Ala Ala Glu Ser Gly Glu Ser Gln Asp 
        115                 120                 125             


Val Thr Tyr Ala Gln Leu Cys Ser Arg Thr Leu Arg Gln Gly Ala Ala 
    130                 135                 140                 


Ala Ser Pro Leu Ser Gln Ala Gly Glu Ala Pro Glu Glu Pro Ser Val 
145                 150                 155                 160 


Tyr Ala Thr Leu Ala Ala Ala Arg Pro Glu Ala Val Pro Lys Asp Met 
                165                 170                 175     


Glu Gln 
        


<210>  269
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  269

Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser 
1               5                   10                  15      


Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly Ser Ala 
            20                  25                  30          


Gly Ser Ala Gly Ser Ala Gly Ser Ala Gly 
        35                  40          


<210>  270
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  270

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  271
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  271

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  272
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  272

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  273
<211>  93
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  273

Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln Trp Ile 
1               5                   10                  15      


Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn His Thr 
            20                  25                  30          


Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His Val Asp 
        35                  40                  45              


Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala Tyr Pro 
    50                  55                  60                  


Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp Asn Ser 
65                  70                  75                  80  


Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                85                  90              


<210>  274
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  274

Lys Cys Tyr Phe Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu 
1               5                   10                  15      


Met Ser Arg Pro Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met 
            20                  25                  30          


Ser Asp Pro Asn Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp 
        35                  40                  45              


Val Arg Asn His Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu 
    50                  55                  60                  


Asn Ser Asp Val Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser 
65                  70                  75                  80  


His Lys Asp Leu Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val 
                85                  90                  95      


Arg Lys Ala Val Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu 
            100                 105                 110         


Gly Ser Leu Asp Gly Thr 
        115             


<210>  275
<211>  74
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  275

His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg Asp Leu Thr Glu 
1               5                   10                  15      


His Lys Pro Ser Val Ser Asn His Thr Gln Asp His Ser Asn Asp Pro 
            20                  25                  30          


Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu Asn Phe Glu Ala 
        35                  40                  45              


Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser Leu Thr Ala Thr 
    50                  55                  60                  


Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
65                  70                  


<210>  276
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  276

Asp Val Val Cys Thr Gly Trp Leu Arg Lys Ser Pro Pro Glu Lys Lys 
1               5                   10                  15      


Leu Arg Arg Tyr Ala Trp Lys Lys Arg Trp Phe Ile Leu Arg Ser Gly 
            20                  25                  30          


Arg Met Ser Gly Asp Pro Asp Val Leu Glu Tyr Tyr Lys Asn Asp His 
        35                  40                  45              


Ser Lys Lys Pro Leu Arg Ile Ile Asn Leu Asn Phe Cys Glu Gln Val 
    50                  55                  60                  


Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Leu Gln Asp Ser Phe Val 
65                  70                  75                  80  


Phe Asp Ile Lys Thr Ser Glu Arg Thr Phe Tyr Leu Val Ala Glu Thr 
                85                  90                  95      


Glu Glu Asp Met Asn Lys Trp Val Gln Ser Ile Cys Gln Ile Cys Gly 
            100                 105                 110         


<210>  277
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  277

Ala Val Met Glu Gly Pro Leu Phe Leu Gln Ser Gln Arg Phe Gly Thr 
1               5                   10                  15      


Lys Arg Trp Arg Lys Thr Trp Ala Val Leu Tyr Pro Ala Ser Pro His 
            20                  25                  30          


Gly Val Ala Arg Leu Glu Phe Phe Asp His Lys Gly Ser Ser Ser Gly 
        35                  40                  45              


Gly Gly Arg Gly Ser Ser Arg Arg Leu Asp Cys Lys Val Ile Arg Leu 
    50                  55                  60                  


Ala Glu Cys Val Ser Val Ala Pro Val Thr Val Glu Thr Pro Pro Glu 
65                  70                  75                  80  


Pro Gly Ala Thr Ala Phe Arg Leu Asp Thr Ala Gln Arg Ser His Leu 
                85                  90                  95      


Leu Ala Ala Asp Ala Pro Ser Ser Ala Ala Trp Val Gln Thr Leu Cys 
            100                 105                 110         


Arg Asn Ala Phe 
        115     


<210>  278
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  278

Gly Ala Val Lys Gln Gly Phe Leu Tyr Leu Gln Gln Gln Gln Thr Phe 
1               5                   10                  15      


Gly Lys Lys Trp Arg Arg Phe Gly Ala Ser Leu Tyr Gly Gly Ser Asp 
            20                  25                  30          


Cys Ala Leu Ala Arg Leu Glu Leu Gln Glu Gly Pro Glu Lys Pro Arg 
        35                  40                  45              


Arg Cys Glu Ala Ala Arg Lys Val Ile Arg Leu Ser Asp Cys Leu Arg 
    50                  55                  60                  


Val Ala Glu Ala Gly Gly Glu Ala Ser Ser Pro Arg Asp Thr Ser Ala 
65                  70                  75                  80  


Phe Phe Leu Glu Thr Lys Glu Arg Leu Tyr Leu Leu Ala Ala Pro Ala 
                85                  90                  95      


Ala Glu Arg Gly Asp Trp Val Gln Ala Ile Cys Leu Leu Ala Phe 
            100                 105                 110     


<210>  279
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  279

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Ser Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  280
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  280

Met Ser Gly Leu Gly Asp Ser Ser Ser Asp Pro Ala Asn Pro Asp Ser 
1               5                   10                  15      


His Lys Arg Lys Gly Ser Pro Cys Asp Thr Leu Ala Ser Ser Thr Glu 
            20                  25                  30          


Lys Arg Arg Arg Glu Gln Glu Asn Lys Tyr Leu Glu Glu Leu Ala Glu 
        35                  40                  45              


Leu Leu Ser Ala Asn Ile Ser Asp Ile Asp Ser Leu Ser Val Lys Pro 
    50                  55                  60                  


Asp Lys Cys Lys Ile Leu Lys Lys Thr Val Asp Gln Ile Gln Leu Met 
65                  70                  75                  80  


Lys Arg Met Glu Gln Glu Lys Ser Thr Thr Asp Asp Asp Val Gln Lys 
                85                  90                  95      


Ser Asp Ile Ser Ser Ser Ser Gln Gly Val Ile Glu Lys Glu Ser Leu 
            100                 105                 110         


Gly Pro Leu Leu Leu Glu Ala Leu Asp Gly Phe Phe Phe Val Val Asn 
        115                 120                 125             


Cys Glu Gly Arg Ile Val Phe Val Ser Glu Asn Val Thr Ser Tyr Leu 
    130                 135                 140                 


Gly Tyr Asn Gln Glu Glu Leu Met Asn Thr Ser Val Tyr Ser Ile Leu 
145                 150                 155                 160 


His Val Gly Asp His Ala Glu Phe Val Lys Asn Leu Leu Pro Lys Ser 
                165                 170                 175     


Leu Val Asn Gly Val Pro Trp Pro Gln Glu Ala Thr Arg Arg Asn Ser 
            180                 185                 190         


His Thr Phe Asn Cys Arg Met Leu Ile His Pro Pro Asp Glu Pro Gly 
        195                 200                 205             


Thr Glu Asn Gln Glu Ala Cys Gln Arg Tyr Glu Val Met Gln Cys Phe 
    210                 215                 220                 


Thr Val Ser Gln Pro Lys Ser Ile Gln Glu Asp Gly Glu Asp Phe Gln 
225                 230                 235                 240 


Ser Cys Leu Ile Cys Ile Ala Arg Arg Leu Pro Arg Pro Pro Ala Ile 
                245                 250                 255     


Thr Gly Val Glu Ser Phe Met Thr Lys Gln Asp Thr Thr Gly Lys Ile 
            260                 265                 270         


Ile Ser Ile Asp Thr Ser Ser Leu Arg Ala Ala Gly Arg Thr Gly Trp 
        275                 280                 285             


Glu Asp Leu Val Arg Lys Cys Ile Tyr Ala Phe Phe Gln Pro Gln Gly 
    290                 295                 300                 


Arg Glu Pro Ser Tyr Ala Arg Gln Leu Phe Gln Glu Val Met Thr Arg 
305                 310                 315                 320 


Gly Thr Ala Ser Ser Pro Ser Tyr Arg Phe Ile Leu Asn Asp Gly Thr 
                325                 330                 335     


Met Leu Ser Ala His Thr Lys Cys Lys Leu Cys Tyr Pro Gln Ser Pro 
            340                 345                 350         


Asp Met Gln Pro Phe Ile Met Gly Ile His Ile Ile Asp Arg Glu His 
        355                 360                 365             


Ser Gly Leu Ser Pro Gln Asp Asp Thr Asn Ser Gly Met Ser Ile Pro 
    370                 375                 380                 


Arg Val Asn Pro Ser Val Asn Pro Ser Ile Ser Pro Ala His Gly Val 
385                 390                 395                 400 


Ala Arg Ser Ser Thr Leu Pro Pro Ser Asn Ser Asn Met Val Ser Thr 
                405                 410                 415     


Arg Ile Asn Arg Gln Gln Ser Ser Asp Leu His Ser Ser Ser His Ser 
            420                 425                 430         


Asn Ser Ser Asn Ser Gln Gly Ser Phe Gly Cys Ser Pro Gly Ser Gln 
        435                 440                 445             


Ile Val Ala Asn Val Ala Leu Asn Gln Gly Gln Ala Ser Ser Gln Ser 
    450                 455                 460                 


Ser Asn Pro Ser Leu Asn Leu Asn Asn Ser Pro Met Glu Gly Thr Gly 
465                 470                 475                 480 


Ile Ser Leu Ala Gln Phe Met Ser Pro Arg Arg Gln Val Thr Ser Gly 
                485                 490                 495     


Leu Ala Thr Arg Pro Arg Met Pro Asn Asn Ser Phe Pro Pro Asn Ile 
            500                 505                 510         


Ser Thr Leu Ser Ser Pro Val Gly Met Thr Ser Ser Ala Cys Asn Asn 
        515                 520                 525             


Asn Asn Arg Ser Tyr Ser Asn Ile Pro Val Thr Ser Leu Gln Gly Met 
    530                 535                 540                 


Asn Glu Gly Pro Asn Asn Ser Val Gly Phe Ser Ala Ser Ser Pro Val 
545                 550                 555                 560 


Leu Arg Gln Met Ser Ser Gln Asn Ser Pro Ser Arg Leu Asn Ile Gln 
                565                 570                 575     


Pro Ala Lys Ala Glu Ser Lys Asp Asn Lys Glu Ile Ala Ser Ile Leu 
            580                 585                 590         


Asn Glu Met Ile Gln Ser Asp Asn Ser Ser Ser Asp Gly Lys Pro Leu 
        595                 600                 605             


Asp Ser Gly Leu Leu His Asn Asn Asp Arg Leu Ser Asp Gly Asp Ser 
    610                 615                 620                 


Lys Tyr Ser Gln Thr Ser His Lys Leu Val Gln Leu Leu Thr Thr Thr 
625                 630                 635                 640 


Ala Glu Gln Gln Leu Arg His Ala Asp Ile Asp Thr Ser Cys Lys Asp 
                645                 650                 655     


Val Leu Ser Cys Thr Gly Thr Ser Asn Ser Ala Ser Ala Asn Ser Ser 
            660                 665                 670         


Gly Gly Ser Cys Pro Ser Ser His Ser Ser Leu Thr Glu Arg His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Ile Thr Thr 
    690                 695                 700                 


Leu Ser Val Glu Pro Asp Lys Lys Asp Ser Ala Ser Thr Ser Val Ser 
705                 710                 715                 720 


Val Thr Gly Gln Val Gln Gly Asn Ser Ser Ile Lys Leu Glu Leu Asp 
                725                 730                 735     


Ala Ser Lys Lys Lys Glu Ser Lys Asp His Gln Leu Leu Arg Tyr Leu 
            740                 745                 750         


Leu Asp Lys Asp Glu Lys Asp Leu Arg Ser Thr Pro Asn Leu Ser Leu 
        755                 760                 765             


Asp Asp Val Lys Val Lys Val Glu Lys Lys Glu Gln Met Asp Pro Cys 
    770                 775                 780                 


Asn Thr Asn Pro Thr Pro Met Thr Lys Pro Thr Pro Glu Glu Ile Lys 
785                 790                 795                 800 


Leu Glu Ala Gln Ser Gln Phe Thr Ala Asp Leu Asp Gln Phe Asp Gln 
                805                 810                 815     


Leu Leu Pro Thr Leu Glu Lys Ala Ala Gln Leu Pro Gly Leu Cys Glu 
            820                 825                 830         


Thr Asp Arg Met Asp Gly Ala Val Thr Ser Val Thr Ile Lys Ser Glu 
        835                 840                 845             


Ile Leu Pro Ala Ser Leu Gln Ser Ala Thr Ala Arg Pro Thr Ser Arg 
    850                 855                 860                 


Leu Asn Arg Leu Pro Glu Leu Glu Leu Glu Ala Ile Asp Asn Gln Phe 
865                 870                 875                 880 


Gly Gln Pro Gly Thr Gly Asp Gln Ile Pro Trp Thr Asn Asn Thr Val 
                885                 890                 895     


Thr Ala Ile Asn Gln Ser Lys Ser Glu Asp Gln Cys Ile Ser Ser Gln 
            900                 905                 910         


Leu Asp Glu Leu Leu Cys Pro Pro Thr Thr Val Glu Gly Arg Asn Asp 
        915                 920                 925             


Glu Lys Ala Leu Leu Glu Gln Leu Val Ser Phe Leu Ser Gly Lys Asp 
    930                 935                 940                 


Glu Thr Glu Leu Ala Glu Leu Asp Arg Ala Leu Gly Ile Asp Lys Leu 
945                 950                 955                 960 


Val Gln Gly Gly Gly Leu Asp Val Leu Ser Glu Arg Phe Pro Pro Gln 
                965                 970                 975     


Gln Ala Thr Pro Pro Leu Ile Met Glu Glu Arg Pro Asn Leu Tyr Ser 
            980                 985                 990         


Gln Pro Tyr Ser Ser Pro Ser Pro  Thr Ala Asn Leu Pro  Ser Pro Phe 
        995                 1000                 1005             


Gln Gly  Met Val Arg Gln Lys  Pro Ser Leu Gly Thr  Met Pro Val 
    1010                 1015                 1020             


Gln Val  Thr Pro Pro Arg Gly  Ala Phe Ser Pro Gly  Met Gly Met 
    1025                 1030                 1035             


Gln Pro  Arg Gln Thr Leu Asn  Arg Pro Pro Ala Ala  Pro Asn Gln 
    1040                 1045                 1050             


Leu Arg  Leu Gln Leu Gln Gln  Arg Leu Gln Gly Gln  Gln Gln Leu 
    1055                 1060                 1065             


Ile His  Gln Asn Arg Gln Ala  Ile Leu Asn Gln Phe  Ala Ala Thr 
    1070                 1075                 1080             


Ala Pro  Val Gly Ile Asn Met  Arg Ser Gly Met Gln  Gln Gln Ile 
    1085                 1090                 1095             


Thr Pro  Gln Pro Pro Leu Asn  Ala Gln Met Leu Ala  Gln Arg Gln 
    1100                 1105                 1110             


Arg Glu  Leu Tyr Ser Gln Gln  His Arg Gln Arg Gln  Leu Ile Gln 
    1115                 1120                 1125             


Gln Gln  Arg Ala Met Leu Met  Arg Gln Gln Ser Phe  Gly Asn Asn 
    1130                 1135                 1140             


Leu Pro  Pro Ser Ser Gly Leu  Pro Val Gln Met Gly  Asn Pro Arg 
    1145                 1150                 1155             


Leu Pro  Gln Gly Ala Pro Gln  Gln Phe Pro Tyr Pro  Pro Asn Tyr 
    1160                 1165                 1170             


Gly Thr  Asn Pro Gly Thr Pro  Pro Ala Ser Thr Ser  Pro Phe Ser 
    1175                 1180                 1185             


Gln Leu  Ala Ala Asn Pro Glu  Ala Ser Leu Ala Asn  Arg Asn Ser 
    1190                 1195                 1200             


Met Val  Ser Arg Gly Met Thr  Gly Asn Ile Gly Gly  Gln Phe Gly 
    1205                 1210                 1215             


Thr Gly  Ile Asn Pro Gln Met  Gln Gln Asn Val Phe  Gln Tyr Pro 
    1220                 1225                 1230             


Gly Ala  Gly Met Val Pro Gln  Gly Glu Ala Asn Phe  Ala Pro Ser 
    1235                 1240                 1245             


Leu Ser  Pro Gly Ser Ser Met  Val Pro Met Pro Ile  Pro Pro Pro 
    1250                 1255                 1260             


Gln Ser  Ser Leu Leu Gln Gln  Thr Pro Pro Ala Ser  Gly Tyr Gln 
    1265                 1270                 1275             


Ser Pro  Asp Met Lys Ala Trp  Gln Gln Gly Ala Ile  Gly Asn Asn 
    1280                 1285                 1290             


Asn Val  Phe Ser Gln Ala Val  Gln Asn Gln Pro Thr  Pro Ala Gln 
    1295                 1300                 1305             


Pro Gly  Val Tyr Asn Asn Met  Ser Ile Thr Val Ser  Met Ala Gly 
    1310                 1315                 1320             


Gly Asn  Thr Asn Val Gln Asn  Met Asn Pro Met Met  Ala Gln Met 
    1325                 1330                 1335             


Gln Met  Ser Ser Leu Gln Met  Pro Gly Met Asn Thr  Val Cys Pro 
    1340                 1345                 1350             


Glu Gln  Ile Asn Asp Pro Ala  Leu Arg His Thr Gly  Leu Tyr Cys 
    1355                 1360                 1365             


Asn Gln  Leu Ser Ser Thr Asp  Leu Leu Lys Thr Glu  Ala Asp Gly 
    1370                 1375                 1380             


Thr Gln  Gln Val Gln Gln Val  Gln Val Phe Ala Asp  Val Gln Cys 
    1385                 1390                 1395             


Thr Val  Asn Leu Val Gly Gly  Asp Pro Tyr Leu Asn  Gln Pro Gly 
    1400                 1405                 1410             


Pro Leu  Gly Thr Gln Lys Pro  Thr Ser Gly Pro Gln  Thr Pro Gln 
    1415                 1420                 1425             


Ala Gln  Gln Lys Ser Leu Leu  Gln Gln Leu Leu Thr  Glu 
    1430                 1435                 1440     


<210>  281
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Ser Gly Met Gly Glu Asn Thr Ser Asp Pro Ser Arg Ala Glu Thr 
1               5                   10                  15      


Arg Lys Arg Lys Glu Cys Pro Asp Gln Leu Gly Pro Ser Pro Lys Arg 
            20                  25                  30          


Asn Thr Glu Lys Arg Asn Arg Glu Gln Glu Asn Lys Tyr Ile Glu Glu 
        35                  40                  45              


Leu Ala Glu Leu Ile Phe Ala Asn Phe Asn Asp Ile Asp Asn Phe Asn 
    50                  55                  60                  


Phe Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Lys Gln Ile 
65                  70                  75                  80  


Arg Gln Ile Lys Glu Gln Glu Lys Ala Ala Ala Ala Asn Ile Asp Glu 
                85                  90                  95      


Val Gln Lys Ser Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys 
            100                 105                 110         


Asp Ala Leu Gly Pro Met Met Leu Glu Ala Leu Asp Gly Phe Phe Phe 
        115                 120                 125             


Val Val Asn Leu Glu Gly Asn Val Val Phe Val Ser Glu Asn Val Thr 
    130                 135                 140                 


Gln Tyr Leu Arg Tyr Asn Gln Glu Glu Leu Met Asn Lys Ser Val Tyr 
145                 150                 155                 160 


Ser Ile Leu His Val Gly Asp His Thr Glu Phe Val Lys Asn Leu Leu 
                165                 170                 175     


Pro Lys Ser Ile Val Asn Gly Gly Ser Trp Ser Gly Glu Pro Pro Arg 
            180                 185                 190         


Arg Asn Ser His Thr Phe Asn Cys Arg Met Leu Val Lys Pro Leu Pro 
        195                 200                 205             


Asp Ser Glu Glu Glu Gly His Asp Asn Gln Glu Ala His Gln Lys Tyr 
    210                 215                 220                 


Glu Thr Met Gln Cys Phe Ala Val Ser Gln Pro Lys Ser Ile Lys Glu 
225                 230                 235                 240 


Glu Gly Glu Asp Leu Gln Ser Cys Leu Ile Cys Val Ala Arg Arg Val 
                245                 250                 255     


Pro Met Lys Glu Arg Pro Val Leu Pro Ser Ser Glu Ser Phe Thr Thr 
            260                 265                 270         


Arg Gln Asp Leu Gln Gly Lys Ile Thr Ser Leu Asp Thr Ser Thr Met 
        275                 280                 285             


Arg Ala Ala Met Lys Pro Gly Trp Glu Asp Leu Val Arg Arg Cys Ile 
    290                 295                 300                 


Gln Lys Phe His Ala Gln His Glu Gly Glu Ser Val Ser Tyr Ala Lys 
305                 310                 315                 320 


Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln Ile 
                325                 330                 335     


Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr Lys 
            340                 345                 350         


Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val Ile 
        355                 360                 365             


Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn Pro 
    370                 375                 380                 


Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser Ser 
385                 390                 395                 400 


Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln Asp 
                405                 410                 415     


Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys Glu 
            420                 425                 430         


Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met Asn 
        435                 440                 445             


His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr Ala 
    450                 455                 460                 


Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro Gly 
465                 470                 475                 480 


Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly Val 
                485                 490                 495     


Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly Ser 
            500                 505                 510         


Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His Ser 
        515                 520                 525             


Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly His 
    530                 535                 540                 


Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met Gly 
545                 550                 555                 560 


Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser Lys 
                565                 570                 575     


Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu Pro 
            580                 585                 590         


Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly Glu 
        595                 600                 605             


Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser Glu 
    610                 615                 620                 


Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr Lys 
625                 630                 635                 640 


Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser Pro 
                645                 650                 655     


Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser Leu 
            660                 665                 670         


Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His Lys 
        675                 680                 685             


Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu Ala 
    690                 695                 700                 


Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser Ser 
705                 710                 715                 720 


Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val Ser 
                725                 730                 735     


Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
            740                 745                 750         


Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu Arg 
        755                 760                 765             


Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala Met 
    770                 775                 780                 


Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro Gly 
785                 790                 795                 800 


Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn Ser 
                805                 810                 815     


Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala Gly 
            820                 825                 830         


Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr Ala 
        835                 840                 845             


Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu Arg 
    850                 855                 860                 


Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly Arg 
865                 870                 875                 880 


Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser Pro 
                885                 890                 895     


Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr Ser 
            900                 905                 910         


Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly Asn 
        915                 920                 925             


Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser Ala 
    930                 935                 940                 


Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser Ala 
945                 950                 955                 960 


Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro Val 
                965                 970                 975     


Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg Pro 
            980                 985                 990         


Ser Ser Gln Pro Gly Gln Arg Gln  Thr Leu Gln Ser Gln  Val Met Asn 
        995                 1000                 1005             


Ile Gly  Pro Ser Glu Leu Glu  Met Asn Met Gly Gly  Pro Gln Tyr 
    1010                 1015                 1020             


Ser Gln  Gln Gln Ala Pro Pro  Asn Gln Thr Ala Pro  Trp Pro Glu 
    1025                 1030                 1035             


Ser Ile  Leu Pro Ile Asp Gln  Ala Ser Phe Ala Ser  Gln Asn Arg 
    1040                 1045                 1050             


Gln Pro  Phe Gly Ser Ser Pro  Asp Asp Leu Leu Cys  Pro His Pro 
    1055                 1060                 1065             


Ala Ala  Glu Ser Pro Ser Asp  Glu Gly Ala Leu Leu  Asp Gln Leu 
    1070                 1075                 1080             


Tyr Leu  Ala Leu Arg Asn Phe  Asp Gly Leu Glu Glu  Ile Asp Arg 
    1085                 1090                 1095             


Ala Leu  Gly Ile Pro Glu Leu  Val Ser Gln Ser Gln  Ala Val Asp 
    1100                 1105                 1110             


Pro Glu  Gln Phe Ser Ser Gln  Asp Ser Asn Ile Met  Leu Glu Gln 
    1115                 1120                 1125             


Lys Ala  Pro Val Phe Pro Gln  Gln Tyr Ala Ser Gln  Ala Gln Met 
    1130                 1135                 1140             


Ala Gln  Gly Ser Tyr Ser Pro  Met Gln Asp Pro Asn  Phe His Thr 
    1145                 1150                 1155             


Met Gly  Gln Arg Pro Ser Tyr  Ala Thr Leu Arg Met  Gln Pro Arg 
    1160                 1165                 1170             


Pro Gly  Leu Arg Pro Thr Gly  Leu Val Gln Asn Gln  Pro Asn Gln 
    1175                 1180                 1185             


Leu Arg  Leu Gln Leu Gln His  Arg Leu Gln Ala Gln  Gln Asn Arg 
    1190                 1195                 1200             


Gln Pro  Leu Met Asn Gln Ile  Ser Asn Val Ser Asn  Val Asn Leu 
    1205                 1210                 1215             


Thr Leu  Arg Pro Gly Val Pro  Thr Gln Ala Pro Ile  Asn Ala Gln 
    1220                 1225                 1230             


Met Leu  Ala Gln Arg Gln Arg  Glu Ile Leu Asn Gln  His Leu Arg 
    1235                 1240                 1245             


Gln Arg  Gln Met His Gln Gln  Gln Gln Val Gln Gln  Arg Thr Leu 
    1250                 1255                 1260             


Met Met  Arg Gly Gln Gly Leu  Asn Met Thr Pro Ser  Met Val Ala 
    1265                 1270                 1275             


Pro Ser  Gly Met Pro Ala Thr  Met Ser Asn Pro Arg  Ile Pro Gln 
    1280                 1285                 1290             


Ala Asn  Ala Gln Gln Phe Pro  Phe Pro Pro Asn Tyr  Gly Ile Ser 
    1295                 1300                 1305             


Gln Gln  Pro Asp Pro Gly Phe  Thr Gly Ala Thr Thr  Pro Gln Ser 
    1310                 1315                 1320             


Pro Leu  Met Ser Pro Arg Met  Ala His Thr Gln Ser  Pro Met Met 
    1325                 1330                 1335             


Gln Gln  Ser Gln Ala Asn Pro  Ala Tyr Gln Ala Pro  Ser Asp Ile 
    1340                 1345                 1350             


Asn Gly  Trp Ala Gln Gly Asn  Met Gly Gly Asn Ser  Met Phe Ser 
    1355                 1360                 1365             


Gln Gln  Ser Pro Pro His Phe  Gly Gln Gln Ala Asn  Thr Ser Met 
    1370                 1375                 1380             


Tyr Ser  Asn Asn Met Asn Ile  Asn Val Ser Met Ala  Thr Asn Thr 
    1385                 1390                 1395             


Gly Gly  Met Ser Ser Met Asn  Gln Met Thr Gly Gln  Ile Ser Met 
    1400                 1405                 1410             


Thr Ser  Val Thr Ser Val Pro  Thr Ser Gly Leu Ser  Ser Met Gly 
    1415                 1420                 1425             


Pro Glu  Gln Val Asn Asp Pro  Ala Leu Arg Gly Gly  Asn Leu Phe 
    1430                 1435                 1440             


Pro Asn  Gln Leu Pro Gly Met  Asp Met Ile Lys Gln  Glu Gly Asp 
    1445                 1450                 1455             


Thr Thr  Arg Lys Tyr Cys 
    1460                 


<210>  282
<211>  1420
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Ser Gly Leu Gly Glu Asn Leu Asp Pro Leu Ala Ser Asp Ser Arg 
1               5                   10                  15      


Lys Arg Lys Leu Pro Cys Asp Thr Pro Gly Gln Gly Leu Thr Cys Ser 
            20                  25                  30          


Gly Glu Lys Arg Arg Arg Glu Gln Glu Ser Lys Tyr Ile Glu Glu Leu 
        35                  40                  45              


Ala Glu Leu Ile Ser Ala Asn Leu Ser Asp Ile Asp Asn Phe Asn Val 
    50                  55                  60                  


Lys Pro Asp Lys Cys Ala Ile Leu Lys Glu Thr Val Arg Gln Ile Arg 
65                  70                  75                  80  


Gln Ile Lys Glu Gln Gly Lys Thr Ile Ser Asn Asp Asp Asp Val Gln 
                85                  90                  95      


Lys Ala Asp Val Ser Ser Thr Gly Gln Gly Val Ile Asp Lys Asp Ser 
            100                 105                 110         


Leu Gly Pro Leu Leu Leu Gln Ala Leu Asp Gly Phe Leu Phe Val Val 
        115                 120                 125             


Asn Arg Asp Gly Asn Ile Val Phe Val Ser Glu Asn Val Thr Gln Tyr 
    130                 135                 140                 


Leu Gln Tyr Lys Gln Glu Asp Leu Val Asn Thr Ser Val Tyr Asn Ile 
145                 150                 155                 160 


Leu His Glu Glu Asp Arg Lys Asp Phe Leu Lys Asn Leu Pro Lys Ser 
                165                 170                 175     


Thr Val Asn Gly Val Ser Trp Thr Asn Glu Thr Gln Arg Gln Lys Ser 
            180                 185                 190         


His Thr Phe Asn Cys Arg Met Leu Met Lys Thr Pro His Asp Ile Leu 
        195                 200                 205             


Glu Asp Ile Asn Ala Ser Pro Glu Met Arg Gln Arg Tyr Glu Thr Met 
    210                 215                 220                 


Gln Cys Phe Ala Leu Ser Gln Pro Arg Ala Met Met Glu Glu Gly Glu 
225                 230                 235                 240 


Asp Leu Gln Ser Cys Met Ile Cys Val Ala Arg Arg Ile Thr Thr Gly 
                245                 250                 255     


Glu Arg Thr Phe Pro Ser Asn Pro Glu Ser Phe Ile Thr Arg His Asp 
            260                 265                 270         


Leu Ser Gly Lys Val Val Asn Ile Asp Thr Asn Ser Leu Arg Ser Ser 
        275                 280                 285             


Met Arg Pro Gly Phe Glu Asp Ile Ile Arg Arg Cys Ile Gln Arg Phe 
    290                 295                 300                 


Phe Ser Leu Asn Asp Gly Gln Ser Trp Ser Gln Lys Arg His Tyr Gln 
305                 310                 315                 320 


Glu Ala Tyr Leu Asn Gly His Ala Glu Thr Pro Val Tyr Arg Phe Ser 
                325                 330                 335     


Leu Ala Asp Gly Thr Ile Val Thr Ala Gln Thr Lys Ser Lys Leu Phe 
            340                 345                 350         


Arg Asn Pro Val Thr Asn Asp Arg His Gly Phe Val Ser Thr His Phe 
        355                 360                 365             


Leu Gln Arg Glu Gln Asn Gly Tyr Arg Pro Asn Pro Asn Pro Val Gly 
    370                 375                 380                 


Gln Gly Ile Arg Pro Pro Met Ala Gly Cys Asn Ser Ser Val Gly Gly 
385                 390                 395                 400 


Met Ser Met Ser Pro Asn Gln Gly Leu Gln Met Pro Ser Ser Arg Ala 
                405                 410                 415     


Tyr Gly Leu Ala Asp Pro Ser Thr Thr Gly Gln Met Ser Gly Ala Arg 
            420                 425                 430         


Tyr Gly Gly Ser Ser Asn Ile Ala Ser Leu Thr Pro Gly Pro Gly Met 
        435                 440                 445             


Gln Ser Pro Ser Ser Tyr Gln Asn Asn Asn Tyr Gly Leu Asn Met Ser 
    450                 455                 460                 


Ser Pro Pro His Gly Ser Pro Gly Leu Ala Pro Asn Gln Gln Asn Ile 
465                 470                 475                 480 


Met Ile Ser Pro Arg Asn Arg Gly Ser Pro Lys Ile Ala Ser His Gln 
                485                 490                 495     


Phe Ser Pro Val Ala Gly Val His Ser Pro Met Ala Ser Ser Gly Asn 
            500                 505                 510         


Thr Gly Asn His Ser Phe Ser Ser Ser Ser Leu Ser Ala Leu Gln Ala 
        515                 520                 525             


Ile Ser Glu Gly Val Gly Thr Ser Leu Leu Ser Thr Leu Ser Ser Pro 
    530                 535                 540                 


Gly Pro Lys Leu Asp Asn Ser Pro Asn Met Asn Ile Thr Gln Pro Ser 
545                 550                 555                 560 


Lys Val Ser Asn Gln Asp Ser Lys Ser Pro Leu Gly Phe Tyr Cys Asp 
                565                 570                 575     


Gln Asn Pro Val Glu Ser Ser Met Cys Gln Ser Asn Ser Arg Asp His 
            580                 585                 590         


Leu Ser Asp Lys Glu Ser Lys Glu Ser Ser Val Glu Gly Ala Glu Asn 
        595                 600                 605             


Gln Arg Gly Pro Leu Glu Ser Lys Gly His Lys Lys Leu Leu Gln Leu 
    610                 615                 620                 


Leu Thr Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser 
625                 630                 635                 640 


Pro Leu Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro 
                645                 650                 655     


Ser Gly Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn 
            660                 665                 670         


Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu 
        675                 680                 685             


Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu 
    690                 695                 700                 


Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn 
705                 710                 715                 720 


Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala 
                725                 730                 735     


Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser 
            740                 745                 750         


Lys Glu Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln 
        755                 760                 765             


Cys Thr Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys 
    770                 775                 780                 


Ile Lys Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu 
785                 790                 795                 800 


Asp Ala Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser 
                805                 810                 815     


Ile Ser Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln Val Phe Gln 
            820                 825                 830         


Gly Thr Asn Ser Leu Gly Leu Lys Ser Ser Gln Ser Val Gln Ser Ile 
        835                 840                 845             


Arg Pro Pro Tyr Asn Arg Ala Val Ser Leu Asp Ser Pro Val Ser Val 
    850                 855                 860                 


Gly Ser Ser Pro Pro Val Lys Asn Ile Ser Ala Phe Pro Met Leu Pro 
865                 870                 875                 880 


Lys Gln Pro Met Leu Gly Gly Asn Pro Arg Met Met Asp Ser Gln Glu 
                885                 890                 895     


Asn Tyr Gly Ser Ser Met Gly Gly Pro Asn Arg Asn Val Thr Val Thr 
            900                 905                 910         


Gln Thr Pro Ser Ser Gly Asp Trp Gly Leu Pro Asn Ser Lys Ala Gly 
        915                 920                 925             


Arg Met Glu Pro Met Asn Ser Asn Ser Met Gly Arg Pro Gly Gly Asp 
    930                 935                 940                 


Tyr Asn Thr Ser Leu Pro Arg Pro Ala Leu Gly Gly Ser Ile Pro Thr 
945                 950                 955                 960 


Leu Pro Leu Arg Ser Asn Ser Ile Pro Gly Ala Arg Pro Val Leu Gln 
                965                 970                 975     


Gln Gln Gln Gln Met Leu Gln Met Arg Pro Gly Glu Ile Pro Met Gly 
            980                 985                 990         


Met Gly Ala Asn Pro Tyr Gly Gln  Ala Ala Ala Ser Asn  Gln Leu Gly 
        995                 1000                 1005             


Ser Trp  Pro Asp Gly Met Leu  Ser Met Glu Gln Val  Ser His Gly 
    1010                 1015                 1020             


Thr Gln  Asn Arg Pro Leu Leu  Arg Asn Ser Leu Asp  Asp Leu Val 
    1025                 1030                 1035             


Gly Pro  Pro Ser Asn Leu Glu  Gly Gln Ser Asp Glu  Arg Ala Leu 
    1040                 1045                 1050             


Leu Asp  Gln Leu His Thr Leu  Leu Ser Asn Thr Asp  Ala Thr Gly 
    1055                 1060                 1065             


Leu Glu  Glu Ile Asp Arg Ala  Leu Gly Ile Pro Glu  Leu Val Asn 
    1070                 1075                 1080             


Gln Gly  Gln Ala Leu Glu Pro  Lys Gln Asp Ala Phe  Gln Gly Gln 
    1085                 1090                 1095             


Glu Ala  Ala Val Met Met Asp  Gln Lys Ala Gly Leu  Tyr Gly Gln 
    1100                 1105                 1110             


Thr Tyr  Pro Ala Gln Gly Pro  Pro Met Gln Gly Gly  Phe His Leu 
    1115                 1120                 1125             


Gln Gly  Gln Ser Pro Ser Phe  Asn Ser Met Met Asn  Gln Met Asn 
    1130                 1135                 1140             


Gln Gln  Gly Asn Phe Pro Leu  Gln Gly Met His Pro  Arg Ala Asn 
    1145                 1150                 1155             


Ile Met  Arg Pro Arg Thr Asn  Thr Pro Lys Gln Leu  Arg Met Gln 
    1160                 1165                 1170             


Leu Gln  Gln Arg Leu Gln Gly  Gln Gln Phe Leu Asn  Gln Ser Arg 
    1175                 1180                 1185             


Gln Ala  Leu Glu Leu Lys Met  Glu Asn Pro Thr Ala  Gly Gly Ala 
    1190                 1195                 1200             


Ala Val  Met Arg Pro Met Met  Gln Pro Gln Gln Gly  Phe Leu Asn 
    1205                 1210                 1215             


Ala Gln  Met Val Ala Gln Arg  Ser Arg Glu Leu Leu  Ser His His 
    1220                 1225                 1230             


Phe Arg  Gln Gln Arg Val Ala  Met Met Met Gln Gln  Gln Gln Gln 
    1235                 1240                 1245             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    1250                 1255                 1260             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Thr Gln Ala  Phe Ser Pro 
    1265                 1270                 1275             


Pro Pro  Asn Val Thr Ala Ser  Pro Ser Met Asp Gly  Leu Leu Ala 
    1280                 1285                 1290             


Gly Pro  Thr Met Pro Gln Ala  Pro Pro Gln Gln Phe  Pro Tyr Gln 
    1295                 1300                 1305             


Pro Asn  Tyr Gly Met Gly Gln  Gln Pro Asp Pro Ala  Phe Gly Arg 
    1310                 1315                 1320             


Val Ser  Ser Pro Pro Asn Ala  Met Met Ser Ser Arg  Met Gly Pro 
    1325                 1330                 1335             


Ser Gln  Asn Pro Met Met Gln  His Pro Gln Ala Ala  Ser Ile Tyr 
    1340                 1345                 1350             


Gln Ser  Ser Glu Met Lys Gly  Trp Pro Ser Gly Asn  Leu Ala Arg 
    1355                 1360                 1365             


Asn Ser  Ser Phe Ser Gln Gln  Gln Phe Ala His Gln  Gly Asn Pro 
    1370                 1375                 1380             


Ala Val  Tyr Ser Met Val His  Met Asn Gly Ser Ser  Gly His Met 
    1385                 1390                 1395             


Gly Gln  Met Asn Met Asn Pro  Met Pro Met Ser Gly  Met Pro Met 
    1400                 1405                 1410             


Gly Pro  Asp Gln Lys Tyr Cys  
    1415                 1420 


<210>  283
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  284
<211>  1023
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Ala Gly Asn Asp Cys Gly Ala Leu Leu Asp Glu Glu Leu Ser Ser 
1               5                   10                  15      


Phe Phe Leu Asn Tyr Leu Ala Asp Thr Gln Gly Gly Gly Ser Gly Glu 
            20                  25                  30          


Glu Gln Leu Tyr Ala Asp Phe Pro Glu Leu Asp Leu Ser Gln Leu Asp 
        35                  40                  45              


Ala Ser Asp Phe Asp Ser Ala Thr Cys Phe Gly Glu Leu Gln Trp Cys 
    50                  55                  60                  


Pro Glu Asn Ser Glu Thr Glu Pro Asn Gln Tyr Ser Pro Asp Asp Ser 
65                  70                  75                  80  


Glu Leu Phe Gln Ile Asp Ser Glu Asn Glu Ala Leu Leu Ala Glu Leu 
                85                  90                  95      


Thr Lys Thr Leu Asp Asp Ile Pro Glu Asp Asp Val Gly Leu Ala Ala 
            100                 105                 110         


Phe Pro Ala Leu Asp Gly Gly Asp Ala Leu Ser Cys Thr Ser Ala Ser 
        115                 120                 125             


Pro Ala Pro Ser Ser Ala Pro Pro Ser Pro Ala Pro Glu Lys Pro Ser 
    130                 135                 140                 


Ala Pro Ala Pro Glu Val Asp Glu Leu Ser Leu Leu Gln Lys Leu Leu 
145                 150                 155                 160 


Leu Ala Thr Ser Tyr Pro Thr Ser Ser Ser Asp Thr Gln Lys Glu Gly 
                165                 170                 175     


Thr Ala Trp Arg Gln Ala Gly Leu Arg Ser Lys Ser Gln Arg Pro Cys 
            180                 185                 190         


Val Lys Ala Asp Ser Thr Gln Asp Lys Lys Ala Pro Met Met Gln Ser 
        195                 200                 205             


Gln Ser Arg Ser Cys Thr Glu Leu His Lys His Leu Thr Ser Ala Gln 
    210                 215                 220                 


Cys Cys Leu Gln Asp Arg Gly Leu Gln Pro Pro Cys Leu Gln Ser Pro 
225                 230                 235                 240 


Arg Leu Pro Ala Lys Glu Asp Lys Glu Pro Gly Glu Asp Cys Pro Ser 
                245                 250                 255     


Pro Gln Pro Ala Pro Ala Ser Pro Arg Asp Ser Leu Ala Leu Gly Arg 
            260                 265                 270         


Ala Asp Pro Gly Ala Pro Val Ser Gln Glu Asp Met Gln Ala Met Val 
        275                 280                 285             


Gln Leu Ile Arg Tyr Met His Thr Tyr Cys Leu Pro Gln Arg Lys Leu 
    290                 295                 300                 


Pro Pro Gln Thr Pro Glu Pro Leu Pro Lys Ala Cys Ser Asn Pro Ser 
305                 310                 315                 320 


Gln Gln Val Arg Ser Arg Pro Trp Ser Arg His His Ser Lys Ala Ser 
                325                 330                 335     


Trp Ala Glu Phe Ser Ile Leu Arg Glu Leu Leu Ala Gln Asp Val Leu 
            340                 345                 350         


Cys Asp Val Ser Lys Pro Tyr Arg Leu Ala Thr Pro Val Tyr Ala Ser 
        355                 360                 365             


Leu Thr Pro Arg Ser Arg Pro Arg Pro Pro Lys Asp Ser Gln Ala Ser 
    370                 375                 380                 


Pro Gly Arg Pro Ser Ser Val Glu Glu Val Arg Ile Ala Ala Ser Pro 
385                 390                 395                 400 


Lys Ser Thr Gly Pro Arg Pro Ser Leu Arg Pro Leu Arg Leu Glu Val 
                405                 410                 415     


Lys Arg Glu Val Arg Arg Pro Ala Arg Leu Gln Gln Gln Glu Glu Glu 
            420                 425                 430         


Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu 
        435                 440                 445             


Glu Glu Trp Gly Arg Lys Arg Pro Gly Arg Gly Leu Pro Trp Thr Lys 
    450                 455                 460                 


Leu Gly Arg Lys Leu Glu Ser Ser Val Cys Pro Val Arg Arg Ser Arg 
465                 470                 475                 480 


Arg Leu Asn Pro Glu Leu Gly Pro Trp Leu Thr Phe Ala Asp Glu Pro 
                485                 490                 495     


Leu Val Pro Ser Glu Pro Gln Gly Ala Leu Pro Ser Leu Cys Leu Ala 
            500                 505                 510         


Pro Lys Ala Tyr Asp Val Glu Arg Glu Leu Gly Ser Pro Thr Asp Glu 
        515                 520                 525             


Asp Ser Gly Gln Asp Gln Gln Leu Leu Arg Gly Pro Gln Ile Pro Ala 
    530                 535                 540                 


Leu Glu Ser Pro Cys Glu Ser Gly Cys Gly Asp Met Asp Glu Asp Pro 
545                 550                 555                 560 


Ser Cys Pro Gln Leu Pro Pro Arg Asp Ser Pro Arg Cys Leu Met Leu 
                565                 570                 575     


Ala Leu Ser Gln Ser Asp Pro Thr Phe Gly Lys Lys Ser Phe Glu Gln 
            580                 585                 590         


Thr Leu Thr Val Glu Leu Cys Gly Thr Ala Gly Leu Thr Pro Pro Thr 
        595                 600                 605             


Thr Pro Pro Tyr Lys Pro Thr Glu Glu Asp Pro Phe Lys Pro Asp Ile 
    610                 615                 620                 


Lys His Ser Leu Gly Lys Glu Ile Ala Leu Ser Leu Pro Ser Pro Glu 
625                 630                 635                 640 


Gly Leu Ser Leu Lys Ala Thr Pro Gly Ala Ala His Lys Leu Pro Lys 
                645                 650                 655     


Lys His Pro Glu Arg Ser Glu Leu Leu Ser His Leu Arg His Ala Thr 
            660                 665                 670         


Ala Gln Pro Ala Ser Gln Ala Gly Gln Lys Arg Pro Phe Ser Cys Ser 
        675                 680                 685             


Phe Gly Asp His Asp Tyr Cys Gln Val Leu Arg Pro Glu Gly Val Leu 
    690                 695                 700                 


Gln Arg Lys Val Leu Arg Ser Trp Glu Pro Ser Gly Val His Leu Glu 
705                 710                 715                 720 


Asp Trp Pro Gln Gln Gly Ala Pro Trp Ala Glu Ala Gln Ala Pro Gly 
                725                 730                 735     


Arg Glu Glu Asp Arg Ser Cys Asp Ala Gly Ala Pro Pro Lys Asp Ser 
            740                 745                 750         


Thr Leu Leu Arg Asp His Glu Ile Arg Ala Ser Leu Thr Lys His Phe 
        755                 760                 765             


Gly Leu Leu Glu Thr Ala Leu Glu Glu Glu Asp Leu Ala Ser Cys Lys 
    770                 775                 780                 


Ser Pro Glu Tyr Asp Thr Val Phe Glu Asp Ser Ser Ser Ser Ser Gly 
785                 790                 795                 800 


Glu Ser Ser Phe Leu Pro Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
                805                 810                 815     


Glu Glu Asp Asp Glu Glu Glu Asp Ser Gly Val Ser Pro Thr Cys Ser 
            820                 825                 830         


Asp His Cys Pro Tyr Gln Ser Pro Pro Ser Lys Ala Asn Arg Gln Leu 
        835                 840                 845             


Cys Ser Arg Ser Arg Ser Ser Ser Gly Ser Ser Pro Cys His Ser Trp 
    850                 855                 860                 


Ser Pro Ala Thr Arg Arg Asn Phe Arg Cys Glu Ser Arg Gly Pro Cys 
865                 870                 875                 880 


Ser Asp Arg Thr Pro Ser Ile Arg His Ala Arg Lys Arg Arg Glu Lys 
                885                 890                 895     


Ala Ile Gly Glu Gly Arg Val Val Tyr Ile Gln Asn Leu Ser Ser Asp 
            900                 905                 910         


Met Ser Ser Arg Glu Leu Lys Arg Arg Phe Glu Val Phe Gly Glu Ile 
        915                 920                 925             


Glu Glu Cys Glu Val Leu Thr Arg Asn Arg Arg Gly Glu Lys Tyr Gly 
    930                 935                 940                 


Phe Ile Thr Tyr Arg Cys Ser Glu His Ala Ala Leu Ser Leu Thr Lys 
945                 950                 955                 960 


Gly Ala Ala Leu Arg Lys Arg Asn Glu Pro Ser Phe Gln Leu Ser Tyr 
                965                 970                 975     


Gly Gly Leu Arg His Phe Cys Trp Pro Arg Tyr Thr Asp Tyr Asp Ser 
            980                 985                 990         


Asn Ser Glu Glu Ala Leu Pro Ala  Ser Gly Lys Ser Lys  Tyr Glu Ala 
        995                 1000                 1005             


Met Asp  Phe Asp Ser Leu Leu  Lys Glu Ala Gln Gln  Ser Leu His 
    1010                 1015                 1020             


<210>  285
<211>  1664
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Ala Ala Arg Arg Gly Arg Arg Asp Gly Val Ala Pro Pro Pro Ser 
1               5                   10                  15      


Gly Gly Pro Gly Pro Asp Pro Gly Gly Gly Ala Arg Gly Ser Gly Trp 
            20                  25                  30          


Gly Ser Arg Ser Gln Ala Pro Tyr Gly Thr Leu Gly Ala Val Ser Gly 
        35                  40                  45              


Gly Glu Gln Val Leu Leu His Glu Glu Ala Gly Asp Ser Gly Phe Val 
    50                  55                  60                  


Ser Leu Ser Arg Leu Gly Pro Ser Leu Arg Asp Lys Asp Leu Glu Met 
65                  70                  75                  80  


Glu Glu Leu Met Leu Gln Asp Glu Thr Leu Leu Gly Thr Met Gln Ser 
                85                  90                  95      


Tyr Met Asp Ala Ser Leu Ile Ser Leu Ile Glu Asp Phe Gly Ser Leu 
            100                 105                 110         


Gly Glu Ser Arg Leu Ser Leu Glu Asp Gln Asn Glu Val Ser Leu Leu 
        115                 120                 125             


Thr Ala Leu Thr Glu Ile Leu Asp Asn Ala Asp Ser Glu Asn Leu Ser 
    130                 135                 140                 


Pro Phe Asp Ser Ile Pro Asp Ser Glu Leu Leu Val Ser Pro Arg Glu 
145                 150                 155                 160 


Gly Ser Ser Leu His Lys Leu Leu Thr Leu Ser Arg Thr Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Ile Thr Pro Val Asp Pro Leu Gly Pro Ser Thr Gly Ser 
            180                 185                 190         


Ser Arg Gly Ser Gly Val Glu Met Ser Leu Pro Asp Pro Ser Trp Asp 
        195                 200                 205             


Phe Ser Pro Pro Ser Phe Leu Glu Thr Ser Ser Pro Lys Leu Pro Ser 
    210                 215                 220                 


Trp Arg Pro Pro Arg Ser Arg Pro Arg Trp Gly Gln Ser Pro Pro Pro 
225                 230                 235                 240 


Gln Gln Arg Ser Asp Gly Glu Glu Glu Glu Glu Val Ala Ser Phe Ser 
                245                 250                 255     


Gly Gln Ile Leu Ala Gly Glu Leu Asp Asn Cys Val Ser Ser Ile Pro 
            260                 265                 270         


Asp Phe Pro Met His Leu Ala Cys Pro Glu Glu Glu Asp Lys Ala Thr 
        275                 280                 285             


Ala Ala Glu Met Ala Val Pro Ala Ala Gly Asp Glu Ser Ile Ser Ser 
    290                 295                 300                 


Leu Ser Glu Leu Val Arg Ala Met His Pro Tyr Cys Leu Pro Asn Leu 
305                 310                 315                 320 


Thr His Leu Ala Ser Leu Glu Asp Glu Leu Gln Glu Gln Pro Asp Asp 
                325                 330                 335     


Leu Thr Leu Pro Glu Gly Cys Val Val Leu Glu Ile Val Gly Gln Ala 
            340                 345                 350         


Ala Thr Ala Gly Asp Asp Leu Glu Ile Pro Val Val Val Arg Gln Val 
        355                 360                 365             


Ser Pro Gly Pro Arg Pro Val Leu Leu Asp Asp Ser Leu Glu Thr Ser 
    370                 375                 380                 


Ser Ala Leu Gln Leu Leu Met Pro Thr Leu Glu Ser Glu Thr Glu Ala 
385                 390                 395                 400 


Ala Val Pro Lys Val Thr Leu Cys Ser Glu Lys Glu Gly Leu Ser Leu 
                405                 410                 415     


Asn Ser Glu Glu Lys Leu Asp Ser Ala Cys Leu Leu Lys Pro Arg Glu 
            420                 425                 430         


Val Val Glu Pro Val Val Pro Lys Glu Pro Gln Asn Pro Pro Ala Asn 
        435                 440                 445             


Ala Ala Pro Gly Ser Gln Arg Ala Arg Lys Gly Arg Lys Lys Lys Ser 
    450                 455                 460                 


Lys Glu Gln Pro Ala Ala Cys Val Glu Gly Tyr Ala Arg Arg Leu Arg 
465                 470                 475                 480 


Ser Ser Ser Arg Gly Gln Ser Thr Val Gly Thr Glu Val Thr Ser Gln 
                485                 490                 495     


Val Asp Asn Leu Gln Lys Gln Pro Gln Glu Glu Leu Gln Lys Glu Ser 
            500                 505                 510         


Gly Pro Leu Gln Gly Lys Gly Lys Pro Arg Ala Trp Ala Arg Ala Trp 
        515                 520                 525             


Ala Ala Ala Leu Glu Asn Ser Ser Pro Lys Asn Leu Glu Arg Ser Ala 
    530                 535                 540                 


Gly Gln Ser Ser Pro Ala Lys Glu Gly Pro Leu Asp Leu Tyr Pro Lys 
545                 550                 555                 560 


Leu Ala Asp Thr Ile Gln Thr Asn Pro Ile Pro Thr His Leu Ser Leu 
                565                 570                 575     


Val Asp Ser Ala Gln Ala Ser Pro Met Pro Val Asp Ser Val Glu Ala 
            580                 585                 590         


Asp Pro Thr Ala Val Gly Pro Val Leu Ala Gly Pro Val Pro Val Asp 
        595                 600                 605             


Pro Gly Leu Val Asp Leu Ala Ser Thr Ser Ser Glu Leu Val Glu Pro 
    610                 615                 620                 


Leu Pro Ala Glu Pro Val Leu Ile Asn Pro Val Leu Ala Asp Ser Ala 
625                 630                 635                 640 


Ala Val Asp Pro Ala Val Val Pro Ile Ser Asp Asn Leu Pro Pro Val 
                645                 650                 655     


Asp Ala Val Pro Ser Gly Pro Ala Pro Val Asp Leu Ala Leu Val Asp 
            660                 665                 670         


Pro Val Pro Asn Asp Leu Thr Pro Val Asp Pro Val Leu Val Lys Ser 
        675                 680                 685             


Arg Pro Thr Asp Pro Arg Arg Gly Ala Val Ser Ser Ala Leu Gly Gly 
    690                 695                 700                 


Ser Ala Pro Gln Leu Leu Val Glu Ser Glu Ser Leu Asp Pro Pro Lys 
705                 710                 715                 720 


Thr Ile Ile Pro Glu Val Lys Glu Val Val Asp Ser Leu Lys Ile Glu 
                725                 730                 735     


Ser Gly Thr Ser Ala Thr Thr His Glu Ala Arg Pro Arg Pro Leu Ser 
            740                 745                 750         


Leu Ser Glu Tyr Arg Arg Arg Arg Gln Gln Arg Gln Ala Glu Thr Glu 
        755                 760                 765             


Glu Arg Ser Pro Gln Pro Pro Thr Gly Lys Trp Pro Ser Leu Pro Glu 
    770                 775                 780                 


Thr Pro Thr Gly Leu Ala Asp Ile Pro Cys Leu Val Ile Pro Pro Ala 
785                 790                 795                 800 


Pro Ala Lys Lys Thr Ala Leu Gln Arg Ser Pro Glu Thr Pro Leu Glu 
                805                 810                 815     


Ile Cys Leu Val Pro Val Gly Pro Ser Pro Ala Ser Pro Ser Pro Glu 
            820                 825                 830         


Pro Pro Val Ser Lys Pro Val Ala Ser Ser Pro Thr Glu Gln Val Pro 
        835                 840                 845             


Ser Gln Glu Met Pro Leu Leu Ala Arg Pro Ser Pro Pro Val Gln Ser 
    850                 855                 860                 


Val Ser Pro Ala Val Pro Thr Pro Pro Ser Met Ser Ala Ala Leu Pro 
865                 870                 875                 880 


Phe Pro Ala Gly Gly Leu Gly Met Pro Pro Ser Leu Pro Pro Pro Pro 
                885                 890                 895     


Leu Gln Pro Pro Ser Leu Pro Leu Ser Met Gly Pro Val Leu Pro Asp 
            900                 905                 910         


Pro Phe Thr His Tyr Ala Pro Leu Pro Ser Trp Pro Cys Tyr Pro His 
        915                 920                 925             


Val Ser Pro Ser Gly Tyr Pro Cys Leu Pro Pro Pro Pro Thr Val Pro 
    930                 935                 940                 


Leu Val Ser Gly Thr Pro Gly Ala Tyr Ala Val Pro Pro Thr Cys Ser 
945                 950                 955                 960 


Val Pro Trp Ala Pro Pro Pro Ala Pro Val Ser Pro Tyr Ser Ser Thr 
                965                 970                 975     


Cys Thr Tyr Gly Pro Leu Gly Trp Gly Pro Gly Pro Gln His Ala Pro 
            980                 985                 990         


Phe Trp Ser Thr Val Pro Pro Pro  Pro Leu Pro Pro Ala  Ser Ile Gly 
        995                 1000                 1005             


Arg Ala  Val Pro Gln Pro Lys  Met Glu Ser Arg Gly  Thr Pro Ala 
    1010                 1015                 1020             


Gly Pro  Pro Glu Asn Val Leu  Pro Leu Ser Met Ala  Pro Pro Leu 
    1025                 1030                 1035             


Ser Leu  Gly Leu Pro Gly His  Gly Ala Pro Gln Thr  Glu Pro Thr 
    1040                 1045                 1050             


Lys Val  Glu Val Lys Pro Val  Pro Ala Ser Pro His  Pro Lys His 
    1055                 1060                 1065             


Lys Val  Ser Ala Leu Val Gln  Ser Pro Gln Met Lys  Ala Leu Ala 
    1070                 1075                 1080             


Cys Val  Ser Ala Glu Gly Val  Thr Val Glu Glu Pro  Ala Ser Glu 
    1085                 1090                 1095             


Arg Leu  Lys Pro Glu Thr Gln  Glu Thr Arg Pro Arg  Glu Lys Pro 
    1100                 1105                 1110             


Pro Leu  Pro Ala Thr Lys Ala  Val Pro Thr Pro Arg  Gln Ser Thr 
    1115                 1120                 1125             


Val Pro  Lys Leu Pro Ala Val  His Pro Ala Arg Leu  Arg Lys Leu 
    1130                 1135                 1140             


Ser Phe  Leu Pro Thr Pro Arg  Thr Gln Gly Ser Glu  Asp Val Val 
    1145                 1150                 1155             


Gln Ala  Phe Ile Ser Glu Ile  Gly Ile Glu Ala Ser  Asp Leu Ser 
    1160                 1165                 1170             


Ser Leu  Leu Glu Gln Phe Glu  Lys Ser Glu Ala Lys  Lys Glu Cys 
    1175                 1180                 1185             


Pro Pro  Pro Ala Pro Ala Asp  Ser Leu Ala Val Gly  Asn Ser Gly 
    1190                 1195                 1200             


Gly Val  Asp Ile Pro Gln Glu  Lys Arg Pro Leu Asp  Arg Leu Gln 
    1205                 1210                 1215             


Ala Pro  Glu Leu Ala Asn Val  Ala Gly Leu Thr Pro  Pro Ala Thr 
    1220                 1225                 1230             


Pro Pro  His Gln Leu Trp Lys  Pro Leu Ala Ala Val  Ser Leu Leu 
    1235                 1240                 1245             


Ala Lys  Ala Lys Ser Pro Lys  Ser Thr Ala Gln Glu  Gly Thr Leu 
    1250                 1255                 1260             


Lys Pro  Glu Gly Val Thr Glu  Ala Lys His Pro Ala  Ala Val Arg 
    1265                 1270                 1275             


Leu Gln  Glu Gly Val His Gly  Pro Ser Arg Val His  Val Gly Ser 
    1280                 1285                 1290             


Gly Asp  His Asp Tyr Cys Val  Arg Ser Arg Thr Pro  Pro Lys Lys 
    1295                 1300                 1305             


Met Pro  Ala Leu Val Ile Pro  Glu Val Gly Ser Arg  Trp Asn Val 
    1310                 1315                 1320             


Lys Arg  His Gln Asp Ile Thr  Ile Lys Pro Val Leu  Ser Leu Gly 
    1325                 1330                 1335             


Pro Ala  Ala Pro Pro Pro Pro  Cys Ile Ala Ala Ser  Arg Glu Pro 
    1340                 1345                 1350             


Leu Asp  His Arg Thr Ser Ser  Glu Gln Ala Asp Pro  Ser Ala Pro 
    1355                 1360                 1365             


Cys Leu  Ala Pro Ser Ser Leu  Leu Ser Pro Glu Ala  Ser Pro Cys 
    1370                 1375                 1380             


Arg Asn  Asp Met Asn Thr Arg  Thr Pro Pro Glu Pro  Ser Ala Lys 
    1385                 1390                 1395             


Gln Arg  Ser Met Arg Cys Tyr  Arg Lys Ala Cys Arg  Ser Ala Ser 
    1400                 1405                 1410             


Pro Ser  Ser Gln Gly Trp Gln  Gly Arg Arg Gly Arg  Asn Ser Arg 
    1415                 1420                 1425             


Ser Val  Ser Ser Gly Ser Asn  Arg Thr Ser Glu Ala  Ser Ser Ser 
    1430                 1435                 1440             


Ser Ser  Ser Ser Ser Ser Ser  Ser Arg Ser Arg Ser  Arg Ser Leu 
    1445                 1450                 1455             


Ser Pro  Pro His Lys Arg Trp  Arg Arg Ser Ser Cys  Ser Ser Ser 
    1460                 1465                 1470             


Gly Arg  Ser Arg Arg Cys Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    1475                 1480                 1485             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Arg  Ser Arg Ser 
    1490                 1495                 1500             


Arg Ser  Pro Ser Pro Arg Arg  Arg Ser Asp Arg Arg  Arg Arg Tyr 
    1505                 1510                 1515             


Ser Ser  Tyr Arg Ser His Asp  His Tyr Gln Arg Gln  Arg Val Leu 
    1520                 1525                 1530             


Gln Lys  Glu Arg Ala Ile Glu  Glu Arg Arg Val Val  Phe Ile Gly 
    1535                 1540                 1545             


Lys Ile  Pro Gly Arg Met Thr  Arg Ser Glu Leu Lys  Gln Arg Phe 
    1550                 1555                 1560             


Ser Val  Phe Gly Glu Ile Glu  Glu Cys Thr Ile His  Phe Arg Val 
    1565                 1570                 1575             


Gln Gly  Asp Asn Tyr Gly Phe  Val Thr Tyr Arg Tyr  Ala Glu Glu 
    1580                 1585                 1590             


Ala Phe  Ala Ala Ile Glu Ser  Gly His Lys Leu Arg  Gln Ala Asp 
    1595                 1600                 1605             


Glu Gln  Pro Phe Asp Leu Cys  Phe Gly Gly Arg Arg  Gln Phe Cys 
    1610                 1615                 1620             


Lys Arg  Ser Tyr Ser Asp Leu  Asp Ser Asn Arg Glu  Asp Phe Asp 
    1625                 1630                 1635             


Pro Ala  Pro Val Lys Ser Lys  Phe Asp Ser Leu Asp  Phe Asp Thr 
    1640                 1645                 1650             


Leu Leu  Lys Gln Ala Gln Lys  Asn Leu Arg Arg 
    1655                 1660                 


<210>  286
<211>  1581
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Lys Ala Gln Gly Glu Thr Glu Glu Ser Glu Lys Leu Ser Lys Met 
1               5                   10                  15      


Ser Ser Leu Leu Glu Arg Leu His Ala Lys Phe Asn Gln Asn Arg Pro 
            20                  25                  30          


Trp Ser Glu Thr Ile Lys Leu Val Arg Gln Val Met Glu Lys Arg Val 
        35                  40                  45              


Val Met Ser Ser Gly Gly His Gln His Leu Val Ser Cys Leu Glu Thr 
    50                  55                  60                  


Leu Gln Lys Ala Leu Lys Val Thr Ser Leu Pro Ala Met Thr Asp Arg 
65                  70                  75                  80  


Leu Glu Ser Ile Ala Arg Gln Asn Gly Leu Gly Ser His Leu Ser Ala 
                85                  90                  95      


Ser Gly Thr Glu Cys Tyr Ile Thr Ser Asp Met Phe Tyr Val Glu Val 
            100                 105                 110         


Gln Leu Asp Pro Ala Gly Gln Leu Cys Asp Val Lys Val Ala His His 
        115                 120                 125             


Gly Glu Asn Pro Val Ser Cys Pro Glu Leu Val Gln Gln Leu Arg Glu 
    130                 135                 140                 


Lys Asn Phe Asp Glu Phe Ser Lys His Leu Lys Gly Leu Val Asn Leu 
145                 150                 155                 160 


Tyr Asn Leu Pro Gly Asp Asn Lys Leu Lys Thr Lys Met Tyr Leu Ala 
                165                 170                 175     


Leu Gln Ser Leu Glu Gln Asp Leu Ser Lys Met Ala Ile Met Tyr Trp 
            180                 185                 190         


Lys Ala Thr Asn Ala Gly Pro Leu Asp Lys Ile Leu His Gly Ser Val 
        195                 200                 205             


Gly Tyr Leu Thr Pro Arg Ser Gly Gly His Leu Met Asn Leu Lys Tyr 
    210                 215                 220                 


Tyr Val Ser Pro Ser Asp Leu Leu Asp Asp Lys Thr Ala Ser Pro Ile 
225                 230                 235                 240 


Ile Leu His Glu Asn Asn Val Ser Arg Ser Leu Gly Met Asn Ala Ser 
                245                 250                 255     


Val Thr Ile Glu Gly Thr Ser Ala Val Tyr Lys Leu Pro Ile Ala Pro 
            260                 265                 270         


Leu Ile Met Gly Ser His Pro Val Asp Asn Lys Trp Thr Pro Ser Phe 
        275                 280                 285             


Ser Ser Ile Thr Ser Ala Asn Ser Val Asp Leu Pro Ala Cys Phe Phe 
    290                 295                 300                 


Leu Lys Phe Pro Gln Pro Ile Pro Val Ser Arg Ala Phe Val Gln Lys 
305                 310                 315                 320 


Leu Gln Asn Cys Thr Gly Ile Pro Leu Phe Glu Thr Gln Pro Thr Tyr 
                325                 330                 335     


Ala Pro Leu Tyr Glu Leu Ile Thr Gln Phe Glu Leu Ser Lys Asp Pro 
            340                 345                 350         


Asp Pro Ile Pro Leu Asn His Asn Met Arg Phe Tyr Ala Ala Leu Pro 
        355                 360                 365             


Gly Gln Gln His Cys Tyr Phe Leu Asn Lys Asp Ala Pro Leu Pro Asp 
    370                 375                 380                 


Gly Arg Ser Leu Gln Gly Thr Leu Val Ser Lys Ile Thr Phe Gln His 
385                 390                 395                 400 


Pro Gly Arg Val Pro Leu Ile Leu Asn Leu Ile Arg His Gln Val Ala 
                405                 410                 415     


Tyr Asn Thr Leu Ile Gly Ser Cys Val Lys Arg Thr Ile Leu Lys Glu 
            420                 425                 430         


Asp Ser Pro Gly Leu Leu Gln Phe Glu Val Cys Pro Leu Ser Glu Ser 
        435                 440                 445             


Arg Phe Ser Val Ser Phe Gln His Pro Val Asn Asp Ser Leu Val Cys 
    450                 455                 460                 


Val Val Met Asp Val Gln Asp Ser Thr His Val Ser Cys Lys Leu Tyr 
465                 470                 475                 480 


Lys Gly Leu Ser Asp Ala Leu Ile Cys Thr Asp Asp Phe Ile Ala Lys 
                485                 490                 495     


Val Val Gln Arg Cys Met Ser Ile Pro Val Thr Met Arg Ala Ile Arg 
            500                 505                 510         


Arg Lys Ala Glu Thr Ile Gln Ala Asp Thr Pro Ala Leu Ser Leu Ile 
        515                 520                 525             


Ala Glu Thr Val Glu Asp Met Val Lys Lys Asn Leu Pro Pro Ala Ser 
    530                 535                 540                 


Ser Pro Gly Tyr Gly Met Thr Thr Gly Asn Asn Pro Met Ser Gly Thr 
545                 550                 555                 560 


Thr Thr Pro Thr Asn Thr Phe Pro Gly Gly Pro Ile Thr Thr Leu Phe 
                565                 570                 575     


Asn Met Ser Met Ser Ile Lys Asp Arg His Glu Ser Val Gly His Gly 
            580                 585                 590         


Glu Asp Phe Ser Lys Val Ser Gln Asn Pro Ile Leu Thr Ser Leu Leu 
        595                 600                 605             


Gln Ile Thr Gly Asn Gly Gly Ser Thr Ile Gly Ser Ser Pro Thr Pro 
    610                 615                 620                 


Pro His His Thr Pro Pro Pro Val Ser Ser Met Ala Gly Asn Thr Lys 
625                 630                 635                 640 


Asn His Pro Met Leu Met Asn Leu Leu Lys Asp Asn Pro Ala Gln Asp 
                645                 650                 655     


Phe Ser Thr Leu Tyr Gly Ser Ser Pro Leu Glu Arg Gln Asn Ser Ser 
            660                 665                 670         


Ser Gly Ser Pro Arg Met Glu Ile Cys Ser Gly Ser Asn Lys Thr Lys 
        675                 680                 685             


Lys Lys Lys Ser Ser Arg Leu Pro Pro Glu Lys Pro Lys His Gln Thr 
    690                 695                 700                 


Glu Asp Asp Phe Gln Arg Glu Leu Phe Ser Met Asp Val Asp Ser Gln 
705                 710                 715                 720 


Asn Pro Ile Phe Asp Val Asn Met Thr Ala Asp Thr Leu Asp Thr Pro 
                725                 730                 735     


His Ile Thr Pro Ala Pro Ser Gln Cys Ser Thr Pro Pro Thr Thr Tyr 
            740                 745                 750         


Pro Gln Pro Val Pro His Pro Gln Pro Ser Ile Gln Arg Met Val Arg 
        755                 760                 765             


Leu Ser Ser Ser Asp Ser Ile Gly Pro Asp Val Thr Asp Ile Leu Ser 
    770                 775                 780                 


Asp Ile Ala Glu Glu Ala Ser Lys Leu Pro Ser Thr Ser Asp Asp Cys 
785                 790                 795                 800 


Pro Ala Ile Gly Thr Pro Leu Arg Asp Ser Ser Ser Ser Gly His Ser 
                805                 810                 815     


Gln Ser Thr Leu Phe Asp Ser Asp Val Phe Gln Thr Asn Asn Asn Glu 
            820                 825                 830         


Asn Pro Tyr Thr Asp Pro Ala Asp Leu Ile Ala Asp Ala Ala Gly Ser 
        835                 840                 845             


Pro Ser Ser Asp Ser Pro Thr Asn His Phe Phe His Asp Gly Val Asp 
    850                 855                 860                 


Phe Asn Pro Asp Leu Leu Asn Ser Gln Ser Gln Ser Gly Phe Gly Glu 
865                 870                 875                 880 


Glu Tyr Phe Asp Glu Ser Ser Gln Ser Gly Asp Asn Asp Asp Phe Lys 
                885                 890                 895     


Gly Phe Ala Ser Gln Ala Leu Asn Thr Leu Gly Val Pro Met Leu Gly 
            900                 905                 910         


Gly Asp Asn Gly Glu Thr Lys Phe Lys Gly Asn Asn Gln Ala Asp Thr 
        915                 920                 925             


Val Asp Phe Ser Ile Ile Ser Val Ala Gly Lys Ala Leu Ala Pro Ala 
    930                 935                 940                 


Asp Leu Met Glu His His Ser Gly Ser Gln Gly Pro Leu Leu Thr Thr 
945                 950                 955                 960 


Gly Asp Leu Gly Lys Glu Lys Thr Gln Lys Arg Val Lys Glu Gly Asn 
                965                 970                 975     


Gly Thr Ser Asn Ser Thr Leu Ser Gly Pro Gly Leu Asp Ser Lys Pro 
            980                 985                 990         


Gly Lys Arg Ser Arg Thr Pro Ser  Asn Asp Gly Lys Ser  Lys Asp Lys 
        995                 1000                 1005             


Pro Pro  Lys Arg Lys Lys Ala  Asp Thr Glu Gly Lys  Ser Pro Ser 
    1010                 1015                 1020             


His Ser  Ser Ser Asn Arg Pro  Phe Thr Pro Pro Thr  Ser Thr Gly 
    1025                 1030                 1035             


Gly Ser  Lys Ser Pro Gly Ser  Ala Gly Arg Ser Gln  Thr Pro Pro 
    1040                 1045                 1050             


Gly Val  Ala Thr Pro Pro Ile  Pro Lys Ile Thr Ile  Gln Ile Pro 
    1055                 1060                 1065             


Lys Gly  Thr Val Met Val Gly  Lys Pro Ser Ser His  Ser Gln Tyr 
    1070                 1075                 1080             


Thr Ser  Ser Gly Ser Val Ser  Ser Ser Gly Ser Lys  Ser His His 
    1085                 1090                 1095             


Ser His  Ser Ser Ser Ser Ser  Ser Ser Ala Ser Thr  Ser Gly Lys 
    1100                 1105                 1110             


Met Lys  Ser Ser Lys Ser Glu  Gly Ser Ser Ser Ser  Lys Leu Ser 
    1115                 1120                 1125             


Ser Ser  Met Tyr Ser Ser Gln  Gly Ser Ser Gly Ser  Ser Gln Ser 
    1130                 1135                 1140             


Lys Asn  Ser Ser Gln Ser Gly  Gly Lys Pro Gly Ser  Ser Pro Ile 
    1145                 1150                 1155             


Thr Lys  His Gly Leu Ser Ser  Gly Ser Ser Ser Thr  Lys Met Lys 
    1160                 1165                 1170             


Pro Gln  Gly Lys Pro Ser Ser  Leu Met Asn Pro Ser  Leu Ser Lys 
    1175                 1180                 1185             


Pro Asn  Ile Ser Pro Ser His  Ser Arg Pro Pro Gly  Gly Ser Asp 
    1190                 1195                 1200             


Lys Leu  Ala Ser Pro Met Lys  Pro Val Pro Gly Thr  Pro Pro Ser 
    1205                 1210                 1215             


Ser Lys  Ala Lys Ser Pro Ile  Ser Ser Gly Ser Gly  Gly Ser His 
    1220                 1225                 1230             


Met Ser  Gly Thr Ser Ser Ser  Ser Gly Met Lys Ser  Ser Ser Gly 
    1235                 1240                 1245             


Leu Gly  Ser Ser Gly Ser Leu  Ser Gln Lys Thr Pro  Pro Ser Ser 
    1250                 1255                 1260             


Asn Ser  Cys Thr Ala Ser Ser  Ser Ser Phe Ser Ser  Ser Gly Ser 
    1265                 1270                 1275             


Ser Met  Ser Ser Ser Gln Asn  Gln His Gly Ser Ser  Lys Gly Lys 
    1280                 1285                 1290             


Ser Pro  Ser Arg Asn Lys Lys  Pro Ser Leu Thr Ala  Val Ile Asp 
    1295                 1300                 1305             


Lys Leu  Lys His Gly Val Val  Thr Ser Gly Pro Gly  Gly Glu Asp 
    1310                 1315                 1320             


Pro Leu  Asp Gly Gln Met Gly  Val Ser Thr Asn Ser  Ser Ser His 
    1325                 1330                 1335             


Pro Met  Ser Ser Lys His Asn  Met Ser Gly Gly Glu  Phe Gln Gly 
    1340                 1345                 1350             


Lys Arg  Glu Lys Ser Asp Lys  Asp Lys Ser Lys Val  Ser Thr Ser 
    1355                 1360                 1365             


Gly Ser  Ser Val Asp Ser Ser  Lys Lys Thr Ser Glu  Ser Lys Asn 
    1370                 1375                 1380             


Val Gly  Ser Thr Gly Val Ala  Lys Ile Ile Ile Ser  Lys His Asp 
    1385                 1390                 1395             


Gly Gly  Ser Pro Ser Ile Lys  Ala Lys Val Thr Leu  Gln Lys Pro 
    1400                 1405                 1410             


Gly Glu  Ser Ser Gly Glu Gly  Leu Arg Pro Gln Met  Ala Ser Ser 
    1415                 1420                 1425             


Lys Asn  Tyr Gly Ser Pro Leu  Ile Ser Gly Ser Thr  Pro Lys His 
    1430                 1435                 1440             


Glu Arg  Gly Ser Pro Ser His  Ser Lys Ser Pro Ala  Tyr Thr Pro 
    1445                 1450                 1455             


Gln Asn  Leu Asp Ser Glu Ser  Glu Ser Gly Ser Ser  Ile Ala Glu 
    1460                 1465                 1470             


Lys Ser  Tyr Gln Asn Ser Pro  Ser Ser Asp Asp Gly  Ile Arg Pro 
    1475                 1480                 1485             


Leu Pro  Glu Tyr Ser Thr Glu  Lys His Lys Lys His  Lys Lys Glu 
    1490                 1495                 1500             


Lys Lys  Lys Val Lys Asp Lys  Asp Arg Asp Arg Asp  Arg Asp Lys 
    1505                 1510                 1515             


Asp Arg  Asp Lys Lys Lys Ser  His Ser Ile Lys Pro  Glu Ser Trp 
    1520                 1525                 1530             


Ser Lys  Ser Pro Ile Ser Ser  Asp Gln Ser Leu Ser  Met Thr Ser 
    1535                 1540                 1545             


Asn Thr  Ile Leu Ser Ala Asp  Arg Pro Ser Arg Leu  Ser Pro Asp 
    1550                 1555                 1560             


Phe Met  Ile Gly Glu Glu Asp  Asp Asp Leu Met Asp  Val Ala Leu 
    1565                 1570                 1575             


Ile Gly  Asn 
    1580     


<210>  287
<211>  2063
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Val Leu Asp Asp Leu Pro Asn Leu Glu Asp Ile Tyr Thr Ser Leu 
1               5                   10                  15      


Cys Ser Ser Thr Met Glu Asp Ser Glu Met Asp Phe Asp Ser Gly Leu 
            20                  25                  30          


Glu Asp Asp Asp Thr Lys Ser Asp Ser Ile Leu Glu Asp Ser Thr Ile 
        35                  40                  45              


Phe Val Ala Phe Lys Gly Asn Ile Asp Asp Lys Asp Phe Lys Trp Lys 
    50                  55                  60                  


Leu Asp Ala Ile Leu Lys Asn Val Pro Asn Leu Leu His Met Glu Ser 
65                  70                  75                  80  


Ser Lys Leu Lys Val Gln Lys Val Glu Pro Trp Asn Ser Val Arg Val 
                85                  90                  95      


Thr Phe Asn Ile Pro Arg Glu Ala Ala Glu Arg Leu Arg Ile Leu Ala 
            100                 105                 110         


Gln Ser Asn Asn Gln Gln Leu Arg Asp Leu Gly Ile Leu Ser Val Gln 
        115                 120                 125             


Ile Glu Gly Glu Gly Ala Ile Asn Leu Ala Leu Ala Gln Asn Arg Ser 
    130                 135                 140                 


Gln Asp Val Arg Met Asn Gly Pro Met Gly Ala Gly Asn Ser Val Arg 
145                 150                 155                 160 


Met Glu Ala Gly Phe Pro Met Ala Ser Gly Pro Gly Ile Ile Arg Met 
                165                 170                 175     


Asn Asn Pro Ala Thr Val Met Ile Pro Pro Gly Gly Asn Val Ser Ser 
            180                 185                 190         


Ser Met Met Ala Pro Gly Pro Asn Pro Glu Leu Gln Pro Arg Thr Pro 
        195                 200                 205             


Arg Pro Ala Ser Gln Ser Asp Ala Met Asp Pro Leu Leu Ser Gly Leu 
    210                 215                 220                 


His Ile Gln Gln Gln Ser His Pro Ser Gly Ser Leu Ala Pro Pro His 
225                 230                 235                 240 


His Pro Met Gln Pro Val Ser Val Asn Arg Gln Met Asn Pro Ala Asn 
                245                 250                 255     


Phe Pro Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            260                 265                 270         


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln Ala 
        275                 280                 285             


Arg Pro Pro Gln Gln His Gln Gln Gln Gln Pro Gln Gly Ile Arg Pro 
    290                 295                 300                 


Gln Phe Thr Ala Pro Thr Gln Val Pro Val Pro Pro Gly Trp Asn Gln 
305                 310                 315                 320 


Leu Pro Ser Gly Ala Leu Gln Pro Pro Pro Ala Gln Gly Ser Leu Gly 
                325                 330                 335     


Thr Met Thr Ala Asn Gln Gly Trp Lys Lys Ala Pro Leu Pro Gly Pro 
            340                 345                 350         


Met Gln Gln Gln Leu Gln Ala Arg Pro Ser Leu Ala Thr Val Gln Thr 
        355                 360                 365             


Pro Ser His Pro Pro Pro Pro Tyr Pro Phe Gly Ser Gln Gln Ala Ser 
    370                 375                 380                 


Gln Ala His Thr Asn Phe Pro Gln Met Ser Asn Pro Gly Gln Phe Thr 
385                 390                 395                 400 


Ala Pro Gln Met Lys Ser Leu Gln Gly Gly Pro Ser Arg Val Pro Thr 
                405                 410                 415     


Pro Leu Gln Gln Pro His Leu Thr Asn Lys Ser Pro Ala Ser Ser Pro 
            420                 425                 430         


Ser Ser Phe Gln Gln Gly Ser Pro Ala Ser Ser Pro Thr Val Asn Gln 
        435                 440                 445             


Thr Gln Gln Gln Met Gly Pro Arg Pro Pro Gln Asn Asn Pro Leu Pro 
    450                 455                 460                 


Gln Gly Phe Gln Gln Pro Val Ser Ser Pro Gly Arg Asn Pro Met Val 
465                 470                 475                 480 


Gln Gln Gly Asn Val Pro Pro Asn Phe Met Val Met Gln Gln Gln Pro 
                485                 490                 495     


Pro Asn Gln Gly Pro Gln Ser Leu His Pro Gly Leu Gly Gly Met Pro 
            500                 505                 510         


Lys Arg Leu Pro Pro Gly Phe Ser Ala Gly Gln Ala Asn Pro Asn Phe 
        515                 520                 525             


Met Gln Gly Gln Val Pro Ser Thr Thr Ala Thr Thr Pro Gly Asn Ser 
    530                 535                 540                 


Gly Ala Pro Gln Leu Gln Ala Asn Gln Asn Val Gln His Ala Gly Gly 
545                 550                 555                 560 


Gln Gly Ala Gly Pro Pro Gln Asn Gln Met Gln Val Ser His Gly Pro 
                565                 570                 575     


Pro Asn Met Met Gln Pro Ser Leu Met Gly Ile His Gly Asn Met Asn 
            580                 585                 590         


Asn Gln Gln Ala Gly Thr Ser Gly Val Pro Gln Val Asn Leu Ser Asn 
        595                 600                 605             


Met Gln Gly Gln Pro Gln Gln Gly Pro Pro Ser Gln Leu Met Gly Met 
    610                 615                 620                 


His Gln Gln Ile Val Pro Ser Gln Gly Gln Met Val Gln Gln Gln Gly 
625                 630                 635                 640 


Thr Leu Asn Pro Gln Asn Pro Met Ile Leu Ser Arg Ala Gln Leu Met 
                645                 650                 655     


Pro Gln Gly Gln Met Met Val Asn Pro Pro Ser Gln Asn Leu Gly Pro 
            660                 665                 670         


Ser Pro Gln Arg Met Thr Pro Pro Lys Gln Met Leu Ser Gln Gln Gly 
        675                 680                 685             


Pro Gln Met Met Ala Pro His Asn Gln Met Met Gly Pro Gln Gly Gln 
    690                 695                 700                 


Val Leu Leu Gln Gln Asn Pro Met Ile Glu Gln Ile Met Thr Asn Gln 
705                 710                 715                 720 


Met Gln Gly Asn Lys Gln Gln Phe Asn Thr Gln Asn Gln Ser Asn Val 
                725                 730                 735     


Met Pro Gly Pro Ala Gln Ile Met Arg Gly Pro Thr Pro Asn Met Gln 
            740                 745                 750         


Gly Asn Met Val Gln Phe Thr Gly Gln Met Ser Gly Gln Met Leu Pro 
        755                 760                 765             


Gln Gln Gly Pro Val Asn Asn Ser Pro Ser Gln Val Met Gly Ile Gln 
    770                 775                 780                 


Gly Gln Val Leu Arg Pro Pro Gly Pro Ser Pro His Met Ala Gln Gln 
785                 790                 795                 800 


His Gly Asp Pro Ala Thr Thr Ala Asn Asn Asp Val Ser Leu Ser Gln 
                805                 810                 815     


Met Met Pro Asp Val Ser Ile Gln Gln Thr Asn Met Val Pro Pro His 
            820                 825                 830         


Val Gln Ala Met Gln Gly Asn Ser Ala Ser Gly Asn His Phe Ser Gly 
        835                 840                 845             


His Gly Met Ser Phe Asn Ala Pro Phe Ser Gly Ala Pro Asn Gly Asn 
    850                 855                 860                 


Gln Met Ser Cys Gly Gln Asn Pro Gly Phe Pro Val Asn Lys Asp Val 
865                 870                 875                 880 


Thr Leu Thr Ser Pro Leu Leu Val Asn Leu Leu Gln Ser Asp Ile Ser 
                885                 890                 895     


Ala Gly His Phe Gly Val Asn Asn Lys Gln Asn Asn Thr Asn Ala Asn 
            900                 905                 910         


Lys Pro Lys Lys Lys Lys Pro Pro Arg Lys Lys Lys Asn Ser Gln Gln 
        915                 920                 925             


Asp Leu Asn Thr Pro Asp Thr Arg Pro Ala Gly Leu Glu Glu Ala Asp 
    930                 935                 940                 


Gln Pro Pro Leu Pro Gly Glu Gln Gly Ile Asn Leu Asp Asn Ser Gly 
945                 950                 955                 960 


Pro Lys Leu Pro Glu Phe Ser Asn Arg Pro Pro Gly Tyr Pro Ser Gln 
                965                 970                 975     


Pro Val Glu Gln Arg Pro Leu Gln Gln Met Pro Pro Gln Leu Met Gln 
            980                 985                 990         


His Val Ala Pro Pro Pro Gln Pro  Pro Gln Gln Gln Pro  Gln Pro Gln 
        995                 1000                 1005             


Leu Pro  Gln Gln Gln Gln Pro  Pro Pro Pro Ser Gln  Pro Gln Ser 
    1010                 1015                 1020             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Met Met Met  Met Leu Met 
    1025                 1030                 1035             


Met Gln  Gln Asp Pro Lys Ser  Val Arg Leu Pro Val  Ser Gln Asn 
    1040                 1045                 1050             


Val His  Pro Pro Arg Gly Pro  Leu Asn Pro Asp Ser  Gln Arg Met 
    1055                 1060                 1065             


Pro Met  Gln Gln Ser Gly Ser  Val Pro Val Met Val  Ser Leu Gln 
    1070                 1075                 1080             


Gly Pro  Ala Ser Val Pro Pro  Ser Pro Asp Lys Gln  Arg Met Pro 
    1085                 1090                 1095             


Met Pro  Val Asn Thr Pro Leu  Gly Ser Asn Ser Arg  Lys Met Val 
    1100                 1105                 1110             


Tyr Gln  Glu Ser Pro Gln Asn  Pro Ser Ser Ser Pro  Leu Ala Glu 
    1115                 1120                 1125             


Met Ala  Ser Leu Pro Glu Ala  Ser Gly Ser Glu Ala  Pro Ser Val 
    1130                 1135                 1140             


Pro Gly  Gly Pro Asn Asn Met  Pro Ser His Val Val  Leu Pro Gln 
    1145                 1150                 1155             


Asn Gln  Leu Met Met Thr Gly  Pro Lys Pro Gly Pro  Ser Pro Leu 
    1160                 1165                 1170             


Ser Ala  Thr Gln Gly Ala Thr  Pro Gln Gln Pro Pro  Val Asn Ser 
    1175                 1180                 1185             


Leu Pro  Ser Ser His Gly His  His Phe Pro Asn Val  Ala Ala Pro 
    1190                 1195                 1200             


Thr Gln  Thr Ser Arg Pro Lys  Thr Pro Asn Arg Ala  Ser Pro Arg 
    1205                 1210                 1215             


Pro Tyr  Tyr Pro Gln Thr Pro  Asn Asn Arg Pro Pro  Ser Thr Glu 
    1220                 1225                 1230             


Pro Ser  Glu Ile Ser Leu Ser  Pro Glu Arg Leu Asn  Ala Ser Ile 
    1235                 1240                 1245             


Ala Gly  Leu Phe Pro Pro Gln  Ile Asn Ile Pro Leu  Pro Pro Arg 
    1250                 1255                 1260             


Pro Asn  Leu Asn Arg Gly Phe  Asp Gln Gln Gly Leu  Asn Pro Thr 
    1265                 1270                 1275             


Thr Leu  Lys Ala Ile Gly Gln  Ala Pro Ser Asn Leu  Thr Met Asn 
    1280                 1285                 1290             


Pro Ser  Asn Phe Ala Thr Pro  Gln Thr His Lys Leu  Asp Ser Val 
    1295                 1300                 1305             


Val Val  Asn Ser Gly Lys Gln  Ser Asn Ser Gly Ala  Thr Lys Arg 
    1310                 1315                 1320             


Ala Ser  Pro Ser Asn Ser Arg  Arg Ser Ser Pro Gly  Ser Ser Arg 
    1325                 1330                 1335             


Lys Thr  Thr Pro Ser Pro Gly  Arg Gln Asn Ser Lys  Ala Pro Lys 
    1340                 1345                 1350             


Leu Thr  Leu Ala Ser Gln Thr  Asn Ala Ala Leu Leu  Gln Asn Val 
    1355                 1360                 1365             


Glu Leu  Pro Arg Asn Val Leu  Val Ser Pro Thr Pro  Leu Ala Asn 
    1370                 1375                 1380             


Pro Pro  Val Pro Gly Ser Phe  Pro Asn Asn Ser Gly  Leu Asn Pro 
    1385                 1390                 1395             


Gln Asn  Ser Thr Val Ser Val  Ala Ala Val Gly Gly  Val Val Glu 
    1400                 1405                 1410             


Asp Asn  Lys Glu Ser Leu Asn  Val Pro Gln Asp Ser  Asp Cys Gln 
    1415                 1420                 1425             


Asn Ser  Gln Ser Arg Lys Glu  Gln Val Asn Ile Glu  Leu Lys Ala 
    1430                 1435                 1440             


Val Pro  Ala Gln Glu Val Lys  Met Val Val Pro Glu  Asp Gln Ser 
    1445                 1450                 1455             


Lys Lys  Asp Gly Gln Pro Ser  Asp Pro Asn Lys Leu  Pro Ser Val 
    1460                 1465                 1470             


Glu Glu  Asn Lys Asn Leu Val  Ser Pro Ala Met Arg  Glu Ala Pro 
    1475                 1480                 1485             


Thr Ser  Leu Ser Gln Leu Leu  Asp Asn Ser Gly Ala  Pro Asn Val 
    1490                 1495                 1500             


Thr Ile  Lys Pro Pro Gly Leu  Thr Asp Leu Glu Val  Thr Pro Pro 
    1505                 1510                 1515             


Val Val  Ser Gly Glu Asp Leu  Lys Lys Ala Ser Val  Ile Pro Thr 
    1520                 1525                 1530             


Leu Gln  Asp Leu Ser Ser Ser  Lys Glu Pro Ser Asn  Ser Leu Asn 
    1535                 1540                 1545             


Leu Pro  His Ser Asn Glu Leu  Cys Ser Ser Leu Val  His Pro Glu 
    1550                 1555                 1560             


Leu Ser  Glu Val Ser Ser Asn  Val Ala Pro Ser Ile  Pro Pro Val 
    1565                 1570                 1575             


Met Ser  Arg Pro Val Ser Ser  Ser Ser Ile Ser Thr  Pro Leu Pro 
    1580                 1585                 1590             


Pro Asn  Gln Ile Thr Val Phe  Val Thr Ser Asn Pro  Ile Thr Thr 
    1595                 1600                 1605             


Ser Ala  Asn Thr Ser Ala Ala  Leu Pro Thr His Leu  Gln Ser Ala 
    1610                 1615                 1620             


Leu Met  Ser Thr Val Val Thr  Met Pro Asn Ala Gly  Ser Lys Val 
    1625                 1630                 1635             


Met Val  Ser Glu Gly Gln Ser  Ala Ala Gln Ser Asn  Ala Arg Pro 
    1640                 1645                 1650             


Gln Phe  Ile Thr Pro Val Phe  Ile Asn Ser Ser Ser  Ile Ile Gln 
    1655                 1660                 1665             


Val Met  Lys Gly Ser Gln Pro  Ser Thr Ile Pro Ala  Ala Pro Leu 
    1670                 1675                 1680             


Thr Thr  Asn Ser Gly Leu Met  Pro Pro Ser Val Ala  Val Val Gly 
    1685                 1690                 1695             


Pro Leu  His Ile Pro Gln Asn  Ile Lys Phe Ser Ser  Ala Pro Val 
    1700                 1705                 1710             


Pro Pro  Asn Ala Leu Ser Ser  Ser Pro Ala Pro Asn  Ile Gln Thr 
    1715                 1720                 1725             


Gly Arg  Pro Leu Val Leu Ser  Ser Arg Ala Thr Pro  Val Gln Leu 
    1730                 1735                 1740             


Pro Ser  Pro Pro Cys Thr Ser  Ser Pro Val Val Pro  Ser His Pro 
    1745                 1750                 1755             


Pro Val  Gln Gln Val Lys Glu  Leu Asn Pro Asp Glu  Ala Ser Pro 
    1760                 1765                 1770             


Gln Val  Asn Thr Ser Ala Asp  Gln Asn Thr Leu Pro  Ser Ser Gln 
    1775                 1780                 1785             


Ser Thr  Thr Met Val Ser Pro  Leu Leu Thr Asn Ser  Pro Gly Ser 
    1790                 1795                 1800             


Ser Gly  Asn Arg Arg Ser Pro  Val Ser Ser Ser Lys  Gly Lys Gly 
    1805                 1810                 1815             


Lys Val  Asp Lys Ile Gly Gln  Ile Leu Leu Thr Lys  Ala Cys Lys 
    1820                 1825                 1830             


Lys Val  Thr Gly Ser Leu Glu  Lys Gly Glu Glu Gln  Tyr Gly Ala 
    1835                 1840                 1845             


Asp Gly  Glu Thr Glu Gly Gln  Gly Leu Asp Thr Thr  Ala Pro Gly 
    1850                 1855                 1860             


Leu Met  Gly Thr Glu Gln Leu  Ser Thr Glu Leu Asp  Ser Lys Thr 
    1865                 1870                 1875             


Pro Thr  Pro Pro Ala Pro Thr  Leu Leu Lys Met Thr  Ser Ser Pro 
    1880                 1885                 1890             


Val Gly  Pro Gly Thr Ala Ser  Ala Gly Pro Ser Leu  Pro Gly Gly 
    1895                 1900                 1905             


Ala Leu  Pro Thr Ser Val Arg  Ser Ile Val Thr Thr  Leu Val Pro 
    1910                 1915                 1920             


Ser Glu  Leu Ile Ser Ala Val  Pro Thr Thr Lys Ser  Asn His Gly 
    1925                 1930                 1935             


Gly Ile  Ala Ser Glu Ser Leu  Ala Gly Gly Leu Val  Glu Glu Lys 
    1940                 1945                 1950             


Val Gly  Ser His Pro Glu Leu  Leu Pro Ser Ile Ala  Pro Ser Gln 
    1955                 1960                 1965             


Asn Leu  Val Ser Lys Glu Thr  Ser Thr Thr Ala Leu  Gln Ala Ser 
    1970                 1975                 1980             


Val Ala  Arg Pro Glu Leu Glu  Val Asn Ala Ala Ile  Val Ser Gly 
    1985                 1990                 1995             


Gln Ser  Ser Glu Pro Lys Glu  Ile Val Glu Lys Ser  Lys Ile Pro 
    2000                 2005                 2010             


Gly Arg  Arg Asn Ser Arg Thr  Glu Glu Pro Thr Val  Ala Ser Glu 
    2015                 2020                 2025             


Ser Val  Glu Asn Gly His Arg  Lys Arg Ser Ser Arg  Pro Ala Ser 
    2030                 2035                 2040             


Ala Ser  Ser Ser Thr Lys Asp  Ile Thr Ser Ala Val  Gln Ser Lys 
    2045                 2050                 2055             


Arg Arg  Lys Ser Lys 
    2060             


<210>  288
<211>  2442
<212>  PRT
<213>  Homo sapiens

<400>  288

Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210>  289
<211>  2414
<212>  PRT
<213>  Homo sapiens

<400>  289

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210>  290
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  290

Met Asn Thr Ala Pro Ser Arg Pro Ser Pro Thr Arg Arg Asp Pro Tyr 
1               5                   10                  15      


Gly Phe Gly Asp Ser Arg Asp Ser Arg Arg Asp Arg Ser Pro Ile Arg 
            20                  25                  30          


Gly Ser Pro Arg Arg Glu Pro Arg Asp Gly Arg Asn Gly Arg Asp Ala 
        35                  40                  45              


Arg Asp Ser Arg Asp Ile Arg Asp Pro Arg Asp Leu Arg Asp His Arg 
    50                  55                  60                  


His Ser Arg Asp Leu Arg Asp His Arg Asp Ser Arg Ser Val Arg Asp 
65                  70                  75                  80  


Val Arg Asp Val Arg Asp Leu Arg Asp Phe Arg Asp Leu Arg Asp Ser 
                85                  90                  95      


Arg Asp Phe Arg Asp Gln Arg Asp Pro Met Tyr Asp Arg Tyr Arg Asp 
            100                 105                 110         


Met Arg Asp Ser Arg Asp Pro Met Tyr Arg Arg Glu Gly Ser Tyr Asp 
        115                 120                 125             


Arg Tyr Leu Arg Met Asp Asp Tyr Cys Arg Arg Lys Asp Asp Ser Tyr 
    130                 135                 140                 


Phe Asp Arg Tyr Arg Asp Ser Phe Asp Gly Arg Gly Pro Pro Gly Pro 
145                 150                 155                 160 


Glu Ser Gln Ser Arg Ala Lys Glu Arg Leu Lys Arg Glu Glu Arg Arg 
                165                 170                 175     


Arg Glu Glu Leu Tyr Arg Gln Tyr Phe Glu Glu Ile Gln Arg Arg Phe 
            180                 185                 190         


Asp Ala Glu Arg Pro Val Asp Cys Ser Val Ile Val Val Asn Lys Gln 
        195                 200                 205             


Thr Lys Asp Tyr Ala Glu Ser Val Gly Arg Lys Val Arg Asp Leu Gly 
    210                 215                 220                 


Met Val Val Asp Leu Ile Phe Leu Asn Thr Glu Val Ser Leu Ser Gln 
225                 230                 235                 240 


Ala Leu Glu Asp Val Ser Arg Gly Gly Ser Pro Phe Ala Ile Val Ile 
                245                 250                 255     


Thr Gln Gln His Gln Ile His Arg Ser Cys Thr Val Asn Ile Met Phe 
            260                 265                 270         


Gly Thr Pro Gln Glu His Arg Asn Met Pro Gln Ala Asp Ala Met Val 
        275                 280                 285             


Leu Val Ala Arg Asn Tyr Glu Arg Tyr Lys Asn Glu Cys Arg Glu Lys 
    290                 295                 300                 


Glu Arg Glu Glu Ile Ala Arg Gln Ala Ala Lys Met Ala Asp Glu Ala 
305                 310                 315                 320 


Ile Leu Gln Glu Arg Glu Arg Gly Gly Pro Glu Glu Gly Val Arg Gly 
                325                 330                 335     


Gly His Pro Pro Ala Ile Gln Ser Leu Ile Asn Leu Leu Ala Asp Asn 
            340                 345                 350         


Arg Tyr Leu Thr Ala Glu Glu Thr Asp Lys Ile Ile Asn Tyr Leu Arg 
        355                 360                 365             


Glu Arg Lys Glu Arg Leu Met Arg Ser Ser Thr Asp Ser Leu Pro Gly 
    370                 375                 380                 


Pro Ile Ser Arg Gln Pro Leu Gly Ala Thr Ser Gly Ala Ser Leu Lys 
385                 390                 395                 400 


Thr Gln Pro Ser Ser Gln Pro Leu Gln Ser Gly Gln Val Leu Pro Ser 
                405                 410                 415     


Ala Thr Pro Thr Pro Ser Ala Pro Pro Thr Ser Gln Gln Glu Leu Gln 
            420                 425                 430         


Ala Lys Ile Leu Ser Leu Phe Asn Ser Gly Thr Val Thr Ala Asn Ser 
        435                 440                 445             


Ser Ser Ala Ser Pro Ser Val Ala Ala Gly Asn Thr Pro Asn Gln Asn 
    450                 455                 460                 


Phe Ser Thr Ala Ala Asn Ser Gln Pro Gln Gln Arg Ser Gln Ala Ser 
465                 470                 475                 480 


Gly Asn Gln Pro Pro Ser Ile Leu Gly Gln Gly Gly Ser Ala Gln Asn 
                485                 490                 495     


Met Gly Pro Arg Pro Gly Ala Pro Ser Gln Gly Leu Phe Gly Gln Pro 
            500                 505                 510         


Ser Ser Arg Leu Ala Pro Ala Ser Asn Met Thr Ser Gln Arg Pro Val 
        515                 520                 525             


Ser Ser Thr Gly Ile Asn Phe Asp Asn Pro Ser Val Gln Lys Ala Leu 
    530                 535                 540                 


Asp Thr Leu Ile Gln Ser Gly Pro Ala Leu Ser His Leu Val Ser Gln 
545                 550                 555                 560 


Thr Thr Ala Gln Met Gly Gln Pro Gln Ala Pro Met Gly Ser Tyr Gln 
                565                 570                 575     


Arg His Tyr 
            


<210>  291
<211>  614
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Asn Thr Phe Gln Asp Gln Ser Gly Ser Ser Ser Asn Arg Glu Pro 
1               5                   10                  15      


Leu Leu Arg Cys Ser Asp Ala Arg Arg Asp Leu Glu Leu Ala Ile Gly 
            20                  25                  30          


Gly Val Leu Arg Ala Glu Gln Gln Ile Lys Asp Asn Leu Arg Glu Val 
        35                  40                  45              


Lys Ala Gln Ile His Ser Cys Ile Ser Arg His Leu Glu Cys Leu Arg 
    50                  55                  60                  


Ser Arg Glu Val Trp Leu Tyr Glu Gln Val Asp Leu Ile Tyr Gln Leu 
65                  70                  75                  80  


Lys Glu Glu Thr Leu Gln Gln Gln Ala Gln Gln Leu Tyr Ser Leu Leu 
                85                  90                  95      


Gly Gln Phe Asn Cys Leu Thr His Gln Leu Glu Cys Thr Gln Asn Lys 
            100                 105                 110         


Asp Leu Ala Asn Gln Val Ser Val Cys Leu Glu Arg Leu Gly Ser Leu 
        115                 120                 125             


Thr Leu Lys Pro Glu Asp Ser Thr Val Leu Leu Phe Glu Ala Asp Thr 
    130                 135                 140                 


Ile Thr Leu Arg Gln Thr Ile Thr Thr Phe Gly Ser Leu Lys Thr Ile 
145                 150                 155                 160 


Gln Ile Pro Glu His Leu Met Ala His Ala Ser Ser Ala Asn Ile Gly 
                165                 170                 175     


Pro Phe Leu Glu Lys Arg Gly Cys Ile Ser Met Pro Glu Gln Lys Ser 
            180                 185                 190         


Ala Ser Gly Ile Val Ala Val Pro Phe Ser Glu Trp Leu Leu Gly Ser 
        195                 200                 205             


Lys Pro Ala Ser Gly Tyr Gln Ala Pro Tyr Ile Pro Ser Thr Asp Pro 
    210                 215                 220                 


Gln Asp Trp Leu Thr Gln Lys Gln Thr Leu Glu Asn Ser Gln Thr Ser 
225                 230                 235                 240 


Ser Arg Ala Cys Asn Phe Phe Asn Asn Val Gly Gly Asn Leu Lys Gly 
                245                 250                 255     


Leu Glu Asn Trp Leu Leu Lys Ser Glu Lys Ser Ser Tyr Gln Lys Cys 
            260                 265                 270         


Asn Ser His Ser Thr Thr Ser Ser Phe Ser Ile Glu Met Glu Lys Val 
        275                 280                 285             


Gly Asp Gln Glu Leu Pro Asp Gln Asp Glu Met Asp Leu Ser Asp Trp 
    290                 295                 300                 


Leu Val Thr Pro Gln Glu Ser His Lys Leu Arg Lys Pro Glu Asn Gly 
305                 310                 315                 320 


Ser Arg Glu Thr Ser Glu Lys Phe Lys Leu Leu Phe Gln Ser Tyr Asn 
                325                 330                 335     


Val Asn Asp Trp Leu Val Lys Thr Asp Ser Cys Thr Asn Cys Gln Gly 
            340                 345                 350         


Asn Gln Pro Lys Gly Val Glu Ile Glu Asn Leu Gly Asn Leu Lys Cys 
        355                 360                 365             


Leu Asn Asp His Leu Glu Ala Lys Lys Pro Leu Ser Thr Pro Ser Met 
    370                 375                 380                 


Val Thr Glu Asp Trp Leu Val Gln Asn His Gln Asp Pro Cys Lys Val 
385                 390                 395                 400 


Glu Glu Val Cys Arg Ala Asn Glu Pro Cys Thr Ser Phe Ala Glu Cys 
                405                 410                 415     


Val Cys Asp Glu Asn Cys Glu Lys Glu Ala Leu Tyr Lys Trp Leu Leu 
            420                 425                 430         


Lys Lys Glu Gly Lys Asp Lys Asn Gly Met Pro Val Glu Pro Lys Pro 
        435                 440                 445             


Glu Pro Glu Lys His Lys Asp Ser Leu Asn Met Trp Leu Cys Pro Arg 
    450                 455                 460                 


Lys Glu Val Ile Glu Gln Thr Lys Ala Pro Lys Ala Met Thr Pro Ser 
465                 470                 475                 480 


Arg Ile Ala Asp Ser Phe Gln Val Ile Lys Asn Ser Pro Leu Ser Glu 
                485                 490                 495     


Trp Leu Ile Arg Pro Pro Tyr Lys Glu Gly Ser Pro Lys Glu Val Pro 
            500                 505                 510         


Gly Thr Glu Asp Arg Ala Gly Lys Gln Lys Phe Lys Ser Pro Met Asn 
        515                 520                 525             


Thr Ser Trp Cys Ser Phe Asn Thr Ala Asp Trp Val Leu Pro Gly Lys 
    530                 535                 540                 


Lys Met Gly Asn Leu Ser Gln Leu Ser Ser Gly Glu Asp Lys Trp Leu 
545                 550                 555                 560 


Leu Arg Lys Lys Ala Gln Glu Val Leu Leu Asn Ser Pro Leu Gln Glu 
                565                 570                 575     


Glu His Asn Phe Pro Pro Asp His Tyr Gly Leu Pro Ala Val Cys Asp 
            580                 585                 590         


Leu Phe Ala Cys Met Gln Leu Lys Val Asp Lys Glu Lys Trp Leu Tyr 
        595                 600                 605             


Arg Thr Pro Leu Gln Met 
    610                 


<210>  292
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val 
                485                 490                 495     


Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile 
            500                 505                 510         


Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala 
        515                 520                 525             


Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro 
    530                 535                 540                 


Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr Ile Thr 
545                 550                 555                 560 


Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met Ile Asp 
                565                 570                 575     


Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu Pro Asp 
            580                 585                 590         


Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg Lys Asp 
        595                 600                 605             


Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg Thr Val 
    610                 615                 620                 


Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly Pro Val 
625                 630                 635                 640 


Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala Ser Ser 
                645                 650                 655     


Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala Gly Ala 
            660                 665                 670         


Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile Arg Ile 
        675                 680                 685             


Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro Val Val 
    690                 695                 700                 


Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn Ala Asn 
705                 710                 715                 720 


Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser Gln Ser 
                725                 730                 735     


Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp Ser Thr 
            740                 745                 750         


Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly Lys Ser 
        755                 760                 765             


Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly Glu Thr 
    770                 775                 780                 


Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn 
785                 790                 795                 800 


Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu 
                805                 810                 815     


Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu Trp Ile 
            820                 825                 830         


Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr Asp Cys 
        835                 840                 845             


Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly Leu Val 
    850                 855                 860                 


Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe 
865                 870                 875                 880 


Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu 
                885                 890                 895     


Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser 
            900                 905                 910         


Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro 
        915                 920                 925             


Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu 
    930                 935                 940                 


Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu 
945                 950                 955                 960 


Asn Tyr Phe Glu Glu Leu Leu Lys Asn Leu Tyr Pro Glu Lys Arg Phe 
                965                 970                 975     


Pro Lys Pro Glu Phe Arg Asn Glu Ser Glu Asp Asn Lys Phe Ser Asp 
            980                 985                 990         


Asp Ser Asp Asp Asp Phe Val Gln  Pro Arg Lys Lys Arg  Leu Lys Ser 
        995                 1000                 1005             


Ile Glu  Glu Arg Gln Leu Leu  Lys 
    1010                 1015     


<210>  293
<211>  2696
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Asp Gln Thr Cys Glu Leu Pro Arg Arg Asn Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Asn Pro Val Asn Leu Asp Ala Pro Glu Asp Lys Asp Ser Pro Phe 
            20                  25                  30          


Gly Asn Gly Gln Ser Asn Phe Ser Glu Pro Leu Asn Gly Cys Thr Met 
        35                  40                  45              


Gln Leu Ser Thr Val Ser Gly Thr Ser Gln Asn Ala Tyr Gly Gln Asp 
    50                  55                  60                  


Ser Pro Ser Cys Tyr Ile Pro Leu Arg Arg Leu Gln Asp Leu Ala Ser 
65                  70                  75                  80  


Met Ile Asn Val Glu Tyr Leu Asn Gly Ser Ala Asp Gly Ser Glu Ser 
                85                  90                  95      


Phe Gln Asp Pro Glu Lys Ser Asp Ser Arg Ala Gln Thr Pro Ile Val 
            100                 105                 110         


Cys Thr Ser Leu Ser Pro Gly Gly Pro Thr Ala Leu Ala Met Lys Gln 
        115                 120                 125             


Glu Pro Ser Cys Asn Asn Ser Pro Glu Leu Gln Val Lys Val Thr Lys 
    130                 135                 140                 


Thr Ile Lys Asn Gly Phe Leu His Phe Glu Asn Phe Thr Cys Val Asp 
145                 150                 155                 160 


Asp Ala Asp Val Asp Ser Glu Met Asp Pro Glu Gln Pro Val Thr Glu 
                165                 170                 175     


Asp Glu Ser Ile Glu Glu Ile Phe Glu Glu Thr Gln Thr Asn Ala Thr 
            180                 185                 190         


Cys Asn Tyr Glu Thr Lys Ser Glu Asn Gly Val Lys Val Ala Met Gly 
        195                 200                 205             


Ser Glu Gln Asp Ser Thr Pro Glu Ser Arg His Gly Ala Val Lys Ser 
    210                 215                 220                 


Pro Phe Leu Pro Leu Ala Pro Gln Thr Glu Thr Gln Lys Asn Lys Gln 
225                 230                 235                 240 


Arg Asn Glu Val Asp Gly Ser Asn Glu Lys Ala Ala Leu Leu Pro Ala 
                245                 250                 255     


Pro Phe Ser Leu Gly Asp Thr Asn Ile Thr Ile Glu Glu Gln Leu Asn 
            260                 265                 270         


Ser Ile Asn Leu Ser Phe Gln Asp Asp Pro Asp Ser Ser Thr Ser Thr 
        275                 280                 285             


Leu Gly Asn Met Leu Glu Leu Pro Gly Thr Ser Ser Ser Ser Thr Ser 
    290                 295                 300                 


Gln Glu Leu Pro Phe Cys Gln Pro Lys Lys Lys Ser Thr Pro Leu Lys 
305                 310                 315                 320 


Tyr Glu Val Gly Asp Leu Ile Trp Ala Lys Phe Lys Arg Arg Pro Trp 
                325                 330                 335     


Trp Pro Cys Arg Ile Cys Ser Asp Pro Leu Ile Asn Thr His Ser Lys 
            340                 345                 350         


Met Lys Val Ser Asn Arg Arg Pro Tyr Arg Gln Tyr Tyr Val Glu Ala 
        355                 360                 365             


Phe Gly Asp Pro Ser Glu Arg Ala Trp Val Ala Gly Lys Ala Ile Val 
    370                 375                 380                 


Met Phe Glu Gly Arg His Gln Phe Glu Glu Leu Pro Val Leu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gln Lys Glu Lys Gly Tyr Arg His Lys Val Pro Gln Lys 
                405                 410                 415     


Ile Leu Ser Lys Trp Glu Ala Ser Val Gly Leu Ala Glu Gln Tyr Asp 
            420                 425                 430         


Val Pro Lys Gly Ser Lys Asn Arg Lys Cys Ile Pro Gly Ser Ile Lys 
        435                 440                 445             


Leu Asp Ser Glu Glu Asp Met Pro Phe Glu Asp Cys Thr Asn Asp Pro 
    450                 455                 460                 


Glu Ser Glu His Asp Leu Leu Leu Asn Gly Cys Leu Lys Ser Leu Ala 
465                 470                 475                 480 


Phe Asp Ser Glu His Ser Ala Asp Glu Lys Glu Lys Pro Cys Ala Lys 
                485                 490                 495     


Ser Arg Ala Arg Lys Ser Ser Asp Asn Pro Lys Arg Thr Ser Val Lys 
            500                 505                 510         


Lys Gly His Ile Gln Phe Glu Ala His Lys Asp Glu Arg Arg Gly Lys 
        515                 520                 525             


Ile Pro Glu Asn Leu Gly Leu Asn Phe Ile Ser Gly Asp Ile Ser Asp 
    530                 535                 540                 


Thr Gln Ala Ser Asn Glu Leu Ser Arg Ile Ala Asn Ser Leu Thr Gly 
545                 550                 555                 560 


Ser Asn Thr Ala Pro Gly Ser Phe Leu Phe Ser Ser Cys Gly Lys Asn 
                565                 570                 575     


Thr Ala Lys Lys Glu Phe Glu Thr Ser Asn Gly Asp Ser Leu Leu Gly 
            580                 585                 590         


Leu Pro Glu Gly Ala Leu Ile Ser Lys Cys Ser Arg Glu Lys Asn Lys 
        595                 600                 605             


Pro Gln Arg Ser Leu Val Cys Gly Ser Lys Val Lys Leu Cys Tyr Ile 
    610                 615                 620                 


Gly Ala Gly Asp Glu Glu Lys Arg Ser Asp Ser Ile Ser Ile Cys Thr 
625                 630                 635                 640 


Thr Ser Asp Asp Gly Ser Ser Asp Leu Asp Pro Ile Glu His Ser Ser 
                645                 650                 655     


Glu Ser Asp Asn Ser Val Leu Glu Ile Pro Asp Ala Phe Asp Arg Thr 
            660                 665                 670         


Glu Asn Met Leu Ser Met Gln Lys Asn Glu Lys Ile Lys Tyr Ser Arg 
        675                 680                 685             


Phe Ala Ala Thr Asn Thr Arg Val Lys Ala Lys Gln Lys Pro Leu Ile 
    690                 695                 700                 


Ser Asn Ser His Thr Asp His Leu Met Gly Cys Thr Lys Ser Ala Glu 
705                 710                 715                 720 


Pro Gly Thr Glu Thr Ser Gln Val Asn Leu Ser Asp Leu Lys Ala Ser 
                725                 730                 735     


Thr Leu Val His Lys Pro Gln Ser Asp Phe Thr Asn Asp Ala Leu Ser 
            740                 745                 750         


Pro Lys Phe Asn Leu Ser Ser Ser Ile Ser Ser Glu Asn Ser Leu Ile 
        755                 760                 765             


Lys Gly Gly Ala Ala Asn Gln Ala Leu Leu His Ser Lys Ser Lys Gln 
    770                 775                 780                 


Pro Lys Phe Arg Ser Ile Lys Cys Lys His Lys Glu Asn Pro Val Met 
785                 790                 795                 800 


Ala Glu Pro Pro Val Ile Asn Glu Glu Cys Ser Leu Lys Cys Cys Ser 
                805                 810                 815     


Ser Asp Thr Lys Gly Ser Pro Leu Ala Ser Ile Ser Lys Ser Gly Lys 
            820                 825                 830         


Val Asp Gly Leu Lys Leu Leu Asn Asn Met His Glu Lys Thr Arg Asp 
        835                 840                 845             


Ser Ser Asp Ile Glu Thr Ala Val Val Lys His Val Leu Ser Glu Leu 
    850                 855                 860                 


Lys Glu Leu Ser Tyr Arg Ser Leu Gly Glu Asp Val Ser Asp Ser Gly 
865                 870                 875                 880 


Thr Ser Lys Pro Ser Lys Pro Leu Leu Phe Ser Ser Ala Ser Ser Gln 
                885                 890                 895     


Asn His Ile Pro Ile Glu Pro Asp Tyr Lys Phe Ser Thr Leu Leu Met 
            900                 905                 910         


Met Leu Lys Asp Met His Asp Ser Lys Thr Lys Glu Gln Arg Leu Met 
        915                 920                 925             


Thr Ala Gln Asn Leu Val Ser Tyr Arg Ser Pro Gly Arg Gly Asp Cys 
    930                 935                 940                 


Ser Thr Asn Ser Pro Val Gly Val Ser Lys Val Leu Val Ser Gly Gly 
945                 950                 955                 960 


Ser Thr His Asn Ser Glu Lys Lys Gly Asp Gly Thr Gln Asn Ser Ala 
                965                 970                 975     


Asn Pro Ser Pro Ser Gly Gly Asp Ser Ala Leu Ser Gly Glu Leu Ser 
            980                 985                 990         


Ala Ser Leu Pro Gly Leu Leu Ser  Asp Lys Arg Asp Leu  Pro Ala Ser 
        995                 1000                 1005             


Gly Lys  Ser Arg Ser Asp Cys  Val Thr Arg Arg Asn  Cys Gly Arg 
    1010                 1015                 1020             


Ser Lys  Pro Ser Ser Lys Leu  Arg Asp Ala Phe Ser  Ala Gln Met 
    1025                 1030                 1035             


Val Lys  Asn Thr Val Asn Arg  Lys Ala Leu Lys Thr  Glu Arg Lys 
    1040                 1045                 1050             


Arg Lys  Leu Asn Gln Leu Pro  Ser Val Thr Leu Asp  Ala Val Leu 
    1055                 1060                 1065             


Gln Gly  Asp Arg Glu Arg Gly  Gly Ser Leu Arg Gly  Gly Ala Glu 
    1070                 1075                 1080             


Asp Pro  Ser Lys Glu Asp Pro  Leu Gln Ile Met Gly  His Leu Thr 
    1085                 1090                 1095             


Ser Glu  Asp Gly Asp His Phe  Ser Asp Val His Phe  Asp Ser Lys 
    1100                 1105                 1110             


Val Lys  Gln Ser Asp Pro Gly  Lys Ile Ser Glu Lys  Gly Leu Ser 
    1115                 1120                 1125             


Phe Glu  Asn Gly Lys Gly Pro  Glu Leu Asp Ser Val  Met Asn Ser 
    1130                 1135                 1140             


Glu Asn  Asp Glu Leu Asn Gly  Val Asn Gln Val Val  Pro Lys Lys 
    1145                 1150                 1155             


Arg Trp  Gln Arg Leu Asn Gln  Arg Arg Thr Lys Pro  Arg Lys Arg 
    1160                 1165                 1170             


Met Asn  Arg Phe Lys Glu Lys  Glu Asn Ser Glu Cys  Ala Phe Arg 
    1175                 1180                 1185             


Val Leu  Leu Pro Ser Asp Pro  Val Gln Glu Gly Arg  Asp Glu Phe 
    1190                 1195                 1200             


Pro Glu  His Arg Thr Pro Ser  Ala Ser Ile Leu Glu  Glu Pro Leu 
    1205                 1210                 1215             


Thr Glu  Gln Asn His Ala Asp  Cys Leu Asp Ser Ala  Gly Pro Arg 
    1220                 1225                 1230             


Leu Asn  Val Cys Asp Lys Ser  Ser Ala Ser Ile Gly  Asp Met Glu 
    1235                 1240                 1245             


Lys Glu  Pro Gly Ile Pro Ser  Leu Thr Pro Gln Ala  Glu Leu Pro 
    1250                 1255                 1260             


Glu Pro  Ala Val Arg Ser Glu  Lys Lys Arg Leu Arg  Lys Pro Ser 
    1265                 1270                 1275             


Lys Trp  Leu Leu Glu Tyr Thr  Glu Glu Tyr Asp Gln  Ile Phe Ala 
    1280                 1285                 1290             


Pro Lys  Lys Lys Gln Lys Lys  Val Gln Glu Gln Val  His Lys Val 
    1295                 1300                 1305             


Ser Ser  Arg Cys Glu Glu Glu  Ser Leu Leu Ala Arg  Gly Arg Ser 
    1310                 1315                 1320             


Ser Ala  Gln Asn Lys Gln Val  Asp Glu Asn Ser Leu  Ile Ser Thr 
    1325                 1330                 1335             


Lys Glu  Glu Pro Pro Val Leu  Glu Arg Glu Ala Pro  Phe Leu Glu 
    1340                 1345                 1350             


Gly Pro  Leu Ala Gln Ser Glu  Leu Gly Gly Gly His  Ala Glu Leu 
    1355                 1360                 1365             


Pro Gln  Leu Thr Leu Ser Val  Pro Val Ala Pro Glu  Val Ser Pro 
    1370                 1375                 1380             


Arg Pro  Ala Leu Glu Ser Glu  Glu Leu Leu Val Lys  Thr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Glu Ser Lys Arg Gln  Arg Lys Pro Thr Lys  Lys Leu Leu 
    1400                 1405                 1410             


Glu Ser  Asn Asp Leu Asp Pro  Gly Phe Met Pro Lys  Lys Gly Asp 
    1415                 1420                 1425             


Leu Gly  Leu Ser Lys Lys Cys  Tyr Glu Ala Gly His  Leu Glu Asn 
    1430                 1435                 1440             


Gly Ile  Thr Glu Ser Cys Ala  Thr Ser Tyr Ser Lys  Asp Phe Gly 
    1445                 1450                 1455             


Gly Gly  Thr Thr Lys Ile Phe  Asp Lys Pro Arg Lys  Arg Lys Arg 
    1460                 1465                 1470             


Gln Arg  His Ala Ala Ala Lys  Met Gln Cys Lys Lys  Val Lys Asn 
    1475                 1480                 1485             


Asp Asp  Ser Ser Lys Glu Ile  Pro Gly Ser Glu Gly  Glu Leu Met 
    1490                 1495                 1500             


Pro His  Arg Thr Ala Thr Ser  Pro Lys Glu Thr Val  Glu Glu Gly 
    1505                 1510                 1515             


Val Glu  His Asp Pro Gly Met  Pro Ala Ser Lys Lys  Met Gln Gly 
    1520                 1525                 1530             


Glu Arg  Gly Gly Gly Ala Ala  Leu Lys Glu Asn Val  Cys Gln Asn 
    1535                 1540                 1545             


Cys Glu  Lys Leu Gly Glu Leu  Leu Leu Cys Glu Ala  Gln Cys Cys 
    1550                 1555                 1560             


Gly Ala  Phe His Leu Glu Cys  Leu Gly Leu Thr Glu  Met Pro Arg 
    1565                 1570                 1575             


Gly Lys  Phe Ile Cys Asn Glu  Cys Arg Thr Gly Ile  His Thr Cys 
    1580                 1585                 1590             


Phe Val  Cys Lys Gln Ser Gly  Glu Asp Val Lys Arg  Cys Leu Leu 
    1595                 1600                 1605             


Pro Leu  Cys Gly Lys Phe Tyr  His Glu Glu Cys Val  Gln Lys Tyr 
    1610                 1615                 1620             


Pro Pro  Thr Val Met Gln Asn  Lys Gly Phe Arg Cys  Ser Leu His 
    1625                 1630                 1635             


Ile Cys  Ile Thr Cys His Ala  Ala Asn Pro Ala Asn  Val Ser Ala 
    1640                 1645                 1650             


Ser Lys  Gly Arg Leu Met Arg  Cys Val Arg Cys Pro  Val Ala Tyr 
    1655                 1660                 1665             


His Ala  Asn Asp Phe Cys Leu  Ala Ala Gly Ser Lys  Ile Leu Ala 
    1670                 1675                 1680             


Ser Asn  Ser Ile Ile Cys Pro  Asn His Phe Thr Pro  Arg Arg Gly 
    1685                 1690                 1695             


Cys Arg  Asn His Glu His Val  Asn Val Ser Trp Cys  Phe Val Cys 
    1700                 1705                 1710             


Ser Glu  Gly Gly Ser Leu Leu  Cys Cys Asp Ser Cys  Pro Ala Ala 
    1715                 1720                 1725             


Phe His  Arg Glu Cys Leu Asn  Ile Asp Ile Pro Glu  Gly Asn Trp 
    1730                 1735                 1740             


Tyr Cys  Asn Asp Cys Lys Ala  Gly Lys Lys Pro His  Tyr Arg Glu 
    1745                 1750                 1755             


Ile Val  Trp Val Lys Val Gly  Arg Tyr Arg Trp Trp  Pro Ala Glu 
    1760                 1765                 1770             


Ile Cys  His Pro Arg Ala Val  Pro Ser Asn Ile Asp  Lys Met Arg 
    1775                 1780                 1785             


His Asp  Val Gly Glu Phe Pro  Val Leu Phe Phe Gly  Ser Asn Asp 
    1790                 1795                 1800             


Tyr Leu  Trp Thr His Gln Ala  Arg Val Phe Pro Tyr  Met Glu Gly 
    1805                 1810                 1815             


Asp Val  Ser Ser Lys Asp Lys  Met Gly Lys Gly Val  Asp Gly Thr 
    1820                 1825                 1830             


Tyr Lys  Lys Ala Leu Gln Glu  Ala Ala Ala Arg Phe  Glu Glu Leu 
    1835                 1840                 1845             


Lys Ala  Gln Lys Glu Leu Arg  Gln Leu Gln Glu Asp  Arg Lys Asn 
    1850                 1855                 1860             


Asp Lys  Lys Pro Pro Pro Tyr  Lys His Ile Lys Val  Asn Arg Pro 
    1865                 1870                 1875             


Ile Gly  Arg Val Gln Ile Phe  Thr Ala Asp Leu Ser  Glu Ile Pro 
    1880                 1885                 1890             


Arg Cys  Asn Cys Lys Ala Thr  Asp Glu Asn Pro Cys  Gly Ile Asp 
    1895                 1900                 1905             


Ser Glu  Cys Ile Asn Arg Met  Leu Leu Tyr Glu Cys  His Pro Thr 
    1910                 1915                 1920             


Val Cys  Pro Ala Gly Gly Arg  Cys Gln Asn Gln Cys  Phe Ser Lys 
    1925                 1930                 1935             


Arg Gln  Tyr Pro Glu Val Glu  Ile Phe Arg Thr Leu  Gln Arg Gly 
    1940                 1945                 1950             


Trp Gly  Leu Arg Thr Lys Thr  Asp Ile Lys Lys Gly  Glu Phe Val 
    1955                 1960                 1965             


Asn Glu  Tyr Val Gly Glu Leu  Ile Asp Glu Glu Glu  Cys Arg Ala 
    1970                 1975                 1980             


Arg Ile  Arg Tyr Ala Gln Glu  His Asp Ile Thr Asn  Phe Tyr Met 
    1985                 1990                 1995             


Leu Thr  Leu Asp Lys Asp Arg  Ile Ile Asp Ala Gly  Pro Lys Gly 
    2000                 2005                 2010             


Asn Tyr  Ala Arg Phe Met Asn  His Cys Cys Gln Pro  Asn Cys Glu 
    2015                 2020                 2025             


Thr Gln  Lys Trp Ser Val Asn  Gly Asp Thr Arg Val  Gly Leu Phe 
    2030                 2035                 2040             


Ala Leu  Ser Asp Ile Lys Ala  Gly Thr Glu Leu Thr  Phe Asn Tyr 
    2045                 2050                 2055             


Asn Leu  Glu Cys Leu Gly Asn  Gly Lys Thr Val Cys  Lys Cys Gly 
    2060                 2065                 2070             


Ala Pro  Asn Cys Ser Gly Phe  Leu Gly Val Arg Pro  Lys Asn Gln 
    2075                 2080                 2085             


Pro Ile  Ala Thr Glu Glu Lys  Ser Lys Lys Phe Lys  Lys Lys Gln 
    2090                 2095                 2100             


Gln Gly  Lys Arg Arg Thr Gln  Gly Glu Ile Thr Lys  Glu Arg Glu 
    2105                 2110                 2115             


Asp Glu  Cys Phe Ser Cys Gly  Asp Ala Gly Gln Leu  Val Ser Cys 
    2120                 2125                 2130             


Lys Lys  Pro Gly Cys Pro Lys  Val Tyr His Ala Asp  Cys Leu Asn 
    2135                 2140                 2145             


Leu Thr  Lys Arg Pro Ala Gly  Lys Trp Glu Cys Pro  Trp His Gln 
    2150                 2155                 2160             


Cys Asp  Ile Cys Gly Lys Glu  Ala Ala Ser Phe Cys  Glu Met Cys 
    2165                 2170                 2175             


Pro Ser  Ser Phe Cys Lys Gln  His Arg Glu Gly Met  Leu Phe Ile 
    2180                 2185                 2190             


Ser Lys  Leu Asp Gly Arg Leu  Ser Cys Thr Glu His  Asp Pro Cys 
    2195                 2200                 2205             


Gly Pro  Asn Pro Leu Glu Pro  Gly Glu Ile Arg Glu  Tyr Val Pro 
    2210                 2215                 2220             


Pro Pro  Val Pro Leu Pro Pro  Gly Pro Ser Thr His  Leu Ala Glu 
    2225                 2230                 2235             


Gln Ser  Thr Gly Met Ala Ala  Gln Ala Pro Lys Met  Ser Asp Lys 
    2240                 2245                 2250             


Pro Pro  Ala Asp Thr Asn Gln  Met Leu Ser Leu Ser  Lys Lys Ala 
    2255                 2260                 2265             


Leu Ala  Gly Thr Cys Gln Arg  Pro Leu Leu Pro Glu  Arg Pro Leu 
    2270                 2275                 2280             


Glu Arg  Thr Asp Ser Arg Pro  Gln Pro Leu Asp Lys  Val Arg Asp 
    2285                 2290                 2295             


Leu Ala  Gly Ser Gly Thr Lys  Ser Gln Ser Leu Val  Ser Ser Gln 
    2300                 2305                 2310             


Arg Pro  Leu Asp Arg Pro Pro  Ala Val Ala Gly Pro  Arg Pro Gln 
    2315                 2320                 2325             


Leu Ser  Asp Lys Pro Ser Pro  Val Thr Ser Pro Ser  Ser Ser Pro 
    2330                 2335                 2340             


Ser Val  Arg Ser Gln Pro Leu  Glu Arg Pro Leu Gly  Thr Ala Asp 
    2345                 2350                 2355             


Pro Arg  Leu Asp Lys Ser Ile  Gly Ala Ala Ser Pro  Arg Pro Gln 
    2360                 2365                 2370             


Ser Leu  Glu Lys Thr Ser Val  Pro Thr Gly Leu Arg  Leu Pro Pro 
    2375                 2380                 2385             


Pro Asp  Arg Leu Leu Ile Thr  Ser Ser Pro Lys Pro  Gln Thr Ser 
    2390                 2395                 2400             


Asp Arg  Pro Thr Asp Lys Pro  His Ala Ser Leu Ser  Gln Arg Leu 
    2405                 2410                 2415             


Pro Pro  Pro Glu Lys Val Leu  Ser Ala Val Val Gln  Thr Leu Val 
    2420                 2425                 2430             


Ala Lys  Glu Lys Ala Leu Arg  Pro Val Asp Gln Asn  Thr Gln Ser 
    2435                 2440                 2445             


Lys Asn  Arg Ala Ala Leu Val  Met Asp Leu Ile Asp  Leu Thr Pro 
    2450                 2455                 2460             


Arg Gln  Lys Glu Arg Ala Ala  Ser Pro His Gln Val  Thr Pro Gln 
    2465                 2470                 2475             


Ala Asp  Glu Lys Met Pro Val  Leu Glu Ser Ser Ser  Trp Pro Ala 
    2480                 2485                 2490             


Ser Lys  Gly Leu Gly His Met  Pro Arg Ala Val Glu  Lys Gly Cys 
    2495                 2500                 2505             


Val Ser  Asp Pro Leu Gln Thr  Ser Gly Lys Ala Ala  Ala Pro Ser 
    2510                 2515                 2520             


Glu Asp  Pro Trp Gln Ala Val  Lys Ser Leu Thr Gln  Ala Arg Leu 
    2525                 2530                 2535             


Leu Ser  Gln Pro Pro Ala Lys  Ala Phe Leu Tyr Glu  Pro Thr Thr 
    2540                 2545                 2550             


Gln Ala  Ser Gly Arg Ala Ser  Ala Gly Ala Glu Gln  Thr Pro Gly 
    2555                 2560                 2565             


Pro Leu  Ser Gln Ser Pro Gly  Leu Val Lys Gln Ala  Lys Gln Met 
    2570                 2575                 2580             


Val Gly  Gly Gln Gln Leu Pro  Ala Leu Ala Ala Lys  Ser Gly Gln 
    2585                 2590                 2595             


Ser Phe  Arg Ser Leu Gly Lys  Ala Pro Ala Ser Leu  Pro Thr Glu 
    2600                 2605                 2610             


Glu Lys  Lys Leu Val Thr Thr  Glu Gln Ser Pro Trp  Ala Leu Gly 
    2615                 2620                 2625             


Lys Ala  Ser Ser Arg Ala Gly  Leu Trp Pro Ile Val  Ala Gly Gln 
    2630                 2635                 2640             


Thr Leu  Ala Gln Ser Cys Trp  Ser Ala Gly Ser Thr  Gln Thr Leu 
    2645                 2650                 2655             


Ala Gln  Thr Cys Trp Ser Leu  Gly Arg Gly Gln Asp  Pro Lys Pro 
    2660                 2665                 2670             


Glu Gln  Asn Thr Leu Pro Ala  Leu Asn Gln Ala Pro  Ser Ser His 
    2675                 2680                 2685             


Lys Cys  Ala Glu Ser Glu Gln  Lys 
    2690                 2695     


<210>  294
<211>  951
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Ala Thr Gly Thr Gly Lys His Lys Leu Leu Ser Thr Gly Pro Thr 
1               5                   10                  15      


Glu Pro Trp Ser Ile Arg Glu Lys Leu Cys Leu Ala Ser Ser Val Met 
            20                  25                  30          


Arg Ser Gly Asp Gln Asn Trp Val Ser Val Ser Arg Ala Ile Lys Pro 
        35                  40                  45              


Phe Ala Glu Pro Gly Arg Pro Pro Asp Trp Phe Ser Gln Lys His Cys 
    50                  55                  60                  


Ala Ser Gln Tyr Ser Glu Leu Leu Glu Thr Thr Glu Thr Pro Lys Arg 
65                  70                  75                  80  


Lys Arg Gly Glu Lys Gly Glu Val Val Glu Thr Val Glu Asp Val Ile 
                85                  90                  95      


Val Arg Lys Leu Thr Ala Glu Arg Val Glu Glu Leu Lys Lys Val Ile 
            100                 105                 110         


Lys Glu Thr Gln Glu Arg Tyr Arg Arg Leu Lys Arg Asp Ala Glu Leu 
        115                 120                 125             


Ile Gln Ala Gly His Met Asp Ser Arg Leu Asp Glu Leu Cys Asn Asp 
    130                 135                 140                 


Ile Ala Thr Lys Lys Lys Leu Glu Glu Glu Glu Ala Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ala Thr Asp Ala Ala Tyr Gln Ala Arg Gln Ala Val Lys Thr Pro 
                165                 170                 175     


Pro Arg Arg Leu Pro Thr Val Met Val Arg Ser Pro Ile Asp Ser Ala 
            180                 185                 190         


Ser Pro Gly Gly Asp Tyr Pro Leu Gly Asp Leu Thr Pro Thr Thr Met 
        195                 200                 205             


Glu Glu Ala Thr Ser Gly Val Thr Pro Gly Thr Leu Pro Ser Thr Pro 
    210                 215                 220                 


Val Thr Ser Phe Pro Gly Ile Pro Asp Thr Leu Pro Pro Gly Ser Ala 
225                 230                 235                 240 


Pro Leu Glu Ala Pro Met Thr Pro Val Thr Asp Asp Ser Pro Gln Lys 
                245                 250                 255     


Lys Met Leu Gly Gln Lys Ala Thr Pro Pro Pro Ser Pro Leu Leu Ser 
            260                 265                 270         


Glu Leu Leu Lys Lys Gly Ser Leu Leu Pro Thr Ser Pro Arg Leu Val 
        275                 280                 285             


Asn Glu Ser Glu Met Ala Val Ala Ser Gly His Leu Asn Ser Thr Gly 
    290                 295                 300                 


Val Leu Leu Glu Val Gly Gly Val Leu Pro Met Ile His Gly Gly Glu 
305                 310                 315                 320 


Ile Gln Gln Thr Pro Asn Thr Val Ala Ala Ser Pro Ala Ala Ser Gly 
                325                 330                 335     


Ala Pro Thr Leu Ser Arg Leu Leu Glu Ala Gly Pro Thr Gln Phe Thr 
            340                 345                 350         


Thr Pro Leu Ala Ser Phe Thr Thr Val Ala Ser Glu Pro Pro Val Lys 
        355                 360                 365             


Leu Val Pro Pro Pro Val Glu Ser Val Ser Gln Ala Thr Ile Val Met 
    370                 375                 380                 


Met Pro Ala Leu Pro Ala Pro Ser Ser Ala Pro Ala Val Ser Thr Thr 
385                 390                 395                 400 


Glu Ser Val Ala Pro Val Ser Gln Pro Asp Asn Cys Val Pro Met Glu 
                405                 410                 415     


Ala Val Gly Asp Pro His Thr Val Thr Val Ser Met Asp Ser Ser Glu 
            420                 425                 430         


Ile Ser Met Ile Ile Asn Ser Ile Lys Glu Glu Cys Phe Arg Ser Gly 
        435                 440                 445             


Val Ala Glu Ala Pro Val Gly Ser Lys Ala Pro Ser Ile Asp Gly Lys 
    450                 455                 460                 


Glu Glu Leu Asp Leu Ala Glu Lys Met Asp Ile Ala Val Ser Tyr Thr 
465                 470                 475                 480 


Gly Glu Glu Leu Asp Phe Glu Thr Val Gly Asp Ile Ile Ala Ile Ile 
                485                 490                 495     


Glu Asp Lys Val Asp Asp His Pro Glu Val Leu Asp Val Ala Ala Val 
            500                 505                 510         


Glu Ala Ala Leu Ser Phe Cys Glu Glu Asn Asp Asp Pro Gln Ser Leu 
        515                 520                 525             


Pro Gly Pro Trp Glu His Pro Ile Gln Gln Glu Arg Asp Lys Pro Val 
    530                 535                 540                 


Pro Leu Pro Ala Pro Glu Met Thr Val Lys Gln Glu Arg Leu Asp Phe 
545                 550                 555                 560 


Glu Glu Thr Glu Asn Lys Gly Ile His Glu Leu Val Asp Ile Arg Glu 
                565                 570                 575     


Pro Ser Ala Glu Ile Lys Val Glu Pro Ala Glu Pro Glu Pro Val Ile 
            580                 585                 590         


Ser Gly Ala Glu Ile Val Ala Gly Val Val Pro Ala Thr Ser Met Glu 
        595                 600                 605             


Pro Pro Glu Leu Arg Ser Gln Asp Leu Asp Glu Glu Leu Gly Ser Thr 
    610                 615                 620                 


Ala Ala Gly Glu Ile Val Glu Ala Asp Val Ala Ile Gly Lys Gly Asp 
625                 630                 635                 640 


Glu Thr Pro Leu Thr Asn Val Lys Thr Glu Ala Ser Pro Glu Ser Met 
                645                 650                 655     


Leu Ser Pro Ser His Gly Ser Asn Pro Ile Glu Asp Pro Leu Glu Ala 
            660                 665                 670         


Glu Thr Gln His Lys Phe Glu Met Ser Asp Ser Leu Lys Glu Glu Ser 
        675                 680                 685             


Gly Thr Ile Phe Gly Ser Gln Ile Lys Asp Ala Pro Gly Glu Asp Glu 
    690                 695                 700                 


Glu Glu Asp Gly Val Ser Glu Ala Ala Ser Leu Glu Glu Pro Lys Glu 
705                 710                 715                 720 


Glu Asp Gln Gly Glu Gly Tyr Leu Ser Glu Met Asp Asn Glu Pro Pro 
                725                 730                 735     


Val Ser Glu Ser Asp Asp Gly Phe Ser Ile His Asn Ala Thr Leu Gln 
            740                 745                 750         


Ser His Thr Leu Ala Asp Ser Ile Pro Ser Ser Pro Ala Ser Ser Gln 
        755                 760                 765             


Phe Ser Val Cys Ser Glu Asp Gln Glu Ala Ile Gln Ala Gln Lys Ile 
    770                 775                 780                 


Trp Lys Lys Ala Ile Met Leu Val Trp Arg Ala Ala Ala Asn His Arg 
785                 790                 795                 800 


Tyr Ala Asn Val Phe Leu Gln Pro Val Thr Asp Asp Ile Ala Pro Gly 
                805                 810                 815     


Tyr His Ser Ile Val Gln Arg Pro Met Asp Leu Ser Thr Ile Lys Lys 
            820                 825                 830         


Asn Ile Glu Asn Gly Leu Ile Arg Ser Thr Ala Glu Phe Gln Arg Asp 
        835                 840                 845             


Ile Met Leu Met Phe Gln Asn Ala Val Met Tyr Asn Ser Ser Asp His 
    850                 855                 860                 


Asp Val Tyr His Met Ala Val Glu Met Gln Arg Asp Val Leu Glu Gln 
865                 870                 875                 880 


Ile Gln Gln Phe Leu Ala Thr Gln Leu Ile Met Gln Thr Ser Glu Ser 
                885                 890                 895     


Gly Ile Ser Ala Lys Ser Leu Arg Gly Arg Asp Ser Thr Arg Lys Gln 
            900                 905                 910         


Asp Ala Ser Glu Lys Asp Ser Val Pro Met Gly Ser Pro Ala Phe Leu 
        915                 920                 925             


Leu Ser Leu Phe Asp Gly Gly Thr Arg Gly Arg Arg Cys Ala Ile Glu 
    930                 935                 940                 


Ala Asp Met Lys Met Lys Lys 
945                 950     


<210>  295
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Ala Glu Val Gly Glu Ile Ile Glu Gly Cys Arg Leu Pro Val Leu 
1               5                   10                  15      


Arg Arg Asn Gln Asp Asn Glu Asp Glu Trp Pro Leu Ala Glu Ile Leu 
            20                  25                  30          


Ser Val Lys Asp Ile Ser Gly Arg Lys Leu Phe Tyr Val His Tyr Ile 
        35                  40                  45              


Asp Phe Asn Lys Arg Leu Asp Glu Trp Val Thr His Glu Arg Leu Asp 
    50                  55                  60                  


Leu Lys Lys Ile Gln Phe Pro Lys Lys Glu Ala Lys Thr Pro Thr Lys 
65                  70                  75                  80  


Asn Gly Leu Pro Gly Ser Arg Pro Gly Ser Pro Glu Arg Glu Val Pro 
                85                  90                  95      


Ala Ser Ala Gln Ala Ser Gly Lys Thr Leu Pro Ile Pro Val Gln Ile 
            100                 105                 110         


Thr Leu Arg Phe Asn Leu Pro Lys Glu Arg Glu Ala Ile Pro Gly Gly 
        115                 120                 125             


Glu Pro Asp Gln Pro Leu Ser Ser Ser Ser Cys Leu Gln Pro Asn His 
    130                 135                 140                 


Arg Ser Thr Lys Arg Lys Val Glu Val Val Ser Pro Ala Thr Pro Val 
145                 150                 155                 160 


Pro Ser Glu Thr Ala Pro Ala Ser Val Phe Pro Gln Asn Gly Ala Ala 
                165                 170                 175     


Arg Arg Ala Val Ala Ala Gln Pro Gly Arg Lys Arg Lys Ser Asn Cys 
            180                 185                 190         


Leu Gly Thr Asp Glu Asp Ser Gln Asp Ser Ser Asp Gly Ile Pro Ser 
        195                 200                 205             


Ala Pro Arg Met Thr Gly Ser Leu Val Ser Asp Arg Ser His Asp Asp 
    210                 215                 220                 


Ile Val Thr Arg Met Lys Asn Ile Glu Cys Ile Glu Leu Gly Arg His 
225                 230                 235                 240 


Arg Leu Lys Pro Trp Tyr Phe Ser Pro Tyr Pro Gln Glu Leu Thr Thr 
                245                 250                 255     


Leu Pro Val Leu Tyr Leu Cys Glu Phe Cys Leu Lys Tyr Gly Arg Ser 
            260                 265                 270         


Leu Lys Cys Leu Gln Arg His Leu Thr Lys Cys Asp Leu Arg His Pro 
        275                 280                 285             


Pro Gly Asn Glu Ile Tyr Arg Lys Gly Thr Ile Ser Phe Phe Glu Ile 
    290                 295                 300                 


Asp Gly Arg Lys Asn Lys Ser Tyr Ser Gln Asn Leu Cys Leu Leu Ala 
305                 310                 315                 320 


Lys Cys Phe Leu Asp His Lys Thr Leu Tyr Tyr Asp Thr Asp Pro Phe 
                325                 330                 335     


Leu Phe Tyr Val Met Thr Glu Tyr Asp Cys Lys Gly Phe His Ile Val 
            340                 345                 350         


Gly Tyr Phe Ser Lys Glu Lys Glu Ser Thr Glu Asp Tyr Asn Val Ala 
        355                 360                 365             


Cys Ile Leu Thr Leu Pro Pro Tyr Gln Arg Arg Gly Tyr Gly Lys Leu 
    370                 375                 380                 


Leu Ile Glu Phe Ser Tyr Glu Leu Ser Lys Val Glu Gly Lys Thr Gly 
385                 390                 395                 400 


Thr Pro Glu Lys Pro Leu Ser Asp Leu Gly Leu Leu Ser Tyr Arg Ser 
                405                 410                 415     


Tyr Trp Ser Gln Thr Ile Leu Glu Ile Leu Met Gly Leu Lys Ser Glu 
            420                 425                 430         


Ser Gly Glu Arg Pro Gln Ile Thr Ile Asn Glu Ile Ser Glu Ile Thr 
        435                 440                 445             


Ser Ile Lys Lys Glu Asp Val Ile Ser Thr Leu Gln Tyr Leu Asn Leu 
    450                 455                 460                 


Ile Asn Tyr Tyr Lys Gly Gln Tyr Ile Leu Thr Leu Ser Glu Asp Ile 
465                 470                 475                 480 


Val Asp Gly His Glu Arg Ala Met Leu Lys Arg Leu Leu Arg Ile Asp 
                485                 490                 495     


Ser Lys Cys Leu His Phe Thr Pro Lys Asp Trp Ser Lys Arg Gly Lys 
            500                 505                 510         


Trp 
    


<210>  296
<211>  942
<212>  PRT
<213>  Homo sapiens

<400>  296

Met Asp Thr Lys Glu Glu Lys Lys Glu Arg Lys Gln Ser Tyr Phe Ala 
1               5                   10                  15      


Arg Leu Lys Lys Lys Lys Gln Ala Lys Gln Asn Ala Glu Thr Ala Ser 
            20                  25                  30          


Ala Val Ala Thr Arg Thr His Thr Gly Lys Glu Asp Asn Asn Thr Val 
        35                  40                  45              


Val Leu Glu Pro Asp Lys Cys Asn Ile Ala Val Glu Glu Glu Tyr Met 
    50                  55                  60                  


Thr Asp Glu Lys Lys Lys Arg Lys Ser Asn Gln Leu Lys Glu Ile Arg 
65                  70                  75                  80  


Arg Thr Glu Leu Lys Arg Tyr Tyr Ser Ile Asp Asp Asn Gln Asn Lys 
                85                  90                  95      


Thr His Asp Lys Lys Glu Lys Lys Met Val Val Gln Lys Pro His Gly 
            100                 105                 110         


Thr Met Glu Tyr Thr Ala Gly Asn Gln Asp Thr Leu Asn Ser Ile Ala 
        115                 120                 125             


Leu Lys Phe Asn Ile Thr Pro Asn Lys Leu Val Glu Leu Asn Lys Leu 
    130                 135                 140                 


Phe Thr His Thr Ile Val Pro Gly Gln Val Leu Phe Val Pro Asp Ala 
145                 150                 155                 160 


Asn Ser Pro Ser Ser Thr Leu Arg Leu Ser Ser Ser Ser Pro Gly Ala 
                165                 170                 175     


Thr Val Ser Pro Ser Ser Ser Asp Ala Glu Tyr Asp Lys Leu Pro Asp 
            180                 185                 190         


Ala Asp Leu Ala Arg Lys Ala Leu Lys Pro Ile Glu Arg Val Leu Ser 
        195                 200                 205             


Ser Thr Ser Glu Glu Asp Glu Pro Gly Val Val Lys Phe Leu Lys Met 
    210                 215                 220                 


Asn Cys Arg Tyr Phe Thr Asp Gly Lys Gly Val Val Gly Gly Val Met 
225                 230                 235                 240 


Ile Val Thr Pro Asn Asn Ile Met Phe Asp Pro His Lys Ser Asp Pro 
                245                 250                 255     


Leu Val Ile Glu Asn Gly Cys Glu Glu Tyr Gly Leu Ile Cys Pro Met 
            260                 265                 270         


Glu Glu Val Val Ser Ile Ala Leu Tyr Asn Asp Ile Ser His Met Lys 
        275                 280                 285             


Ile Lys Asp Ala Leu Pro Ser Asp Leu Pro Gln Asp Leu Cys Pro Leu 
    290                 295                 300                 


Tyr Arg Pro Gly Glu Trp Glu Asp Leu Ala Ser Glu Lys Asp Ile Asn 
305                 310                 315                 320 


Pro Phe Ser Lys Phe Lys Ser Ile Asn Lys Glu Lys Arg Gln Gln Asn 
                325                 330                 335     


Gly Glu Lys Ile Met Thr Ser Asp Ser Arg Pro Ile Val Pro Leu Glu 
            340                 345                 350         


Lys Ser Thr Gly His Thr Pro Thr Lys Pro Ser Gly Ser Ser Val Ser 
        355                 360                 365             


Glu Lys Leu Lys Lys Leu Asp Ser Ser Arg Glu Thr Ser His Gly Ser 
    370                 375                 380                 


Pro Thr Val Thr Lys Leu Ser Lys Glu Pro Ser Asp Thr Ser Ser Ala 
385                 390                 395                 400 


Phe Glu Ser Thr Ala Lys Glu Asn Phe Leu Gly Glu Asp Asp Asp Phe 
                405                 410                 415     


Val Asp Leu Glu Glu Leu Ser Ser Gln Thr Gly Gly Gly Met His Lys 
            420                 425                 430         


Lys Asp Thr Leu Lys Glu Cys Leu Ser Leu Asp Pro Glu Glu Arg Lys 
        435                 440                 445             


Lys Ala Glu Ser Gln Ile Asn Asn Ser Ala Val Glu Met Gln Val Gln 
    450                 455                 460                 


Ser Ala Leu Ala Phe Leu Gly Thr Glu Asn Asp Val Glu Leu Lys Gly 
465                 470                 475                 480 


Ala Leu Asp Leu Glu Thr Cys Glu Lys Gln Asp Ile Met Pro Glu Val 
                485                 490                 495     


Asp Lys Gln Ser Gly Ser Pro Glu Ser Arg Val Glu Asn Thr Leu Asn 
            500                 505                 510         


Ile His Glu Asp Leu Asp Lys Val Lys Leu Ile Glu Tyr Tyr Leu Thr 
        515                 520                 525             


Lys Asn Lys Glu Gly Pro Gln Val Ser Glu Asn Leu Gln Lys Thr Glu 
    530                 535                 540                 


Leu Ser Asp Gly Lys Ser Ile Glu Pro Gly Gly Ile Asp Ile Thr Leu 
545                 550                 555                 560 


Ser Ser Ser Leu Ser Gln Ala Gly Asp Pro Ile Thr Glu Gly Asn Lys 
                565                 570                 575     


Glu Pro Asp Lys Thr Trp Val Lys Lys Gly Glu Pro Leu Pro Val Lys 
            580                 585                 590         


Leu Asn Ser Ser Thr Glu Ala Asn Val Ile Lys Glu Ala Leu Asp Ser 
        595                 600                 605             


Ser Leu Glu Ser Thr Leu Asp Asn Ser Cys Gln Gly Ala Gln Met Asp 
    610                 615                 620                 


Asn Lys Ser Glu Val Gln Leu Trp Leu Leu Lys Arg Ile Gln Val Pro 
625                 630                 635                 640 


Ile Glu Asp Ile Leu Pro Ser Lys Glu Glu Lys Ser Lys Thr Pro Pro 
                645                 650                 655     


Met Phe Leu Cys Ile Lys Val Gly Lys Pro Met Arg Lys Ser Phe Ala 
            660                 665                 670         


Thr His Thr Ala Ala Met Val Gln Gln Tyr Gly Lys Arg Arg Lys Gln 
        675                 680                 685             


Pro Glu Tyr Trp Phe Ala Val Pro Arg Glu Arg Val Asp His Leu Tyr 
    690                 695                 700                 


Thr Phe Phe Val Gln Trp Ser Pro Asp Val Tyr Gly Lys Asp Ala Lys 
705                 710                 715                 720 


Glu Gln Gly Phe Val Val Val Glu Lys Glu Glu Leu Asn Met Ile Asp 
                725                 730                 735     


Asn Phe Phe Ser Glu Pro Thr Thr Lys Ser Trp Glu Ile Ile Thr Val 
            740                 745                 750         


Glu Glu Ala Lys Arg Arg Lys Ser Thr Cys Ser Tyr Tyr Glu Asp Glu 
        755                 760                 765             


Asp Glu Glu Val Leu Pro Val Leu Arg Pro His Ser Ala Leu Leu Glu 
    770                 775                 780                 


Asn Met His Ile Glu Gln Leu Ala Arg Arg Leu Pro Ala Arg Val Gln 
785                 790                 795                 800 


Gly Tyr Pro Trp Arg Leu Ala Tyr Ser Thr Leu Glu His Gly Thr Ser 
                805                 810                 815     


Leu Lys Thr Leu Tyr Arg Lys Ser Ala Ser Leu Asp Ser Pro Val Leu 
            820                 825                 830         


Leu Val Ile Lys Asp Met Asp Asn Gln Ile Phe Gly Ala Tyr Ala Thr 
        835                 840                 845             


His Pro Phe Lys Phe Ser Asp His Tyr Tyr Gly Thr Gly Glu Thr Phe 
    850                 855                 860                 


Leu Tyr Thr Phe Ser Pro His Phe Lys Val Phe Lys Trp Ser Gly Glu 
865                 870                 875                 880 


Asn Ser Tyr Phe Ile Asn Gly Asp Ile Ser Ser Leu Glu Leu Gly Gly 
                885                 890                 895     


Gly Gly Gly Arg Phe Gly Leu Trp Leu Asp Ala Asp Leu Tyr His Gly 
            900                 905                 910         


Arg Ser Asn Ser Cys Ser Thr Phe Asn Asn Asp Ile Leu Ser Lys Lys 
        915                 920                 925             


Glu Asp Phe Ile Val Gln Asp Leu Glu Val Trp Ala Phe Asp 
    930                 935                 940         


<210>  297
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Leu Phe Ile Phe Pro Leu Ser Leu Pro Trp Arg Pro Ser Cys Trp 
1               5                   10                  15      


Lys Glu Ser Cys Ser Thr Gly Gln Arg Gln Ala Gly Arg Ser Arg Glu 
            20                  25                  30          


Asp Ser Val Thr Pro Pro Pro Ser Ser Pro Trp Pro Thr Pro Pro Ala 
        35                  40                  45              


Gly Ala Met Ser Thr Lys Gln Glu Ala Arg Arg Asp Glu Gly Glu Ala 
    50                  55                  60                  


Arg Thr Arg Gly Gln Glu Ala Gln Leu Arg Asp Arg Ala His Leu Ser 
65                  70                  75                  80  


Gln Gln Arg Arg Leu Lys Gln Ala Thr Gln Phe Leu His Lys Asp Ser 
                85                  90                  95      


Ala Asp Leu Leu Pro Leu Asp Ser Leu Lys Arg Leu Gly Thr Ser Lys 
            100                 105                 110         


Asp Leu Gln Pro Arg Ser Val Ile Gln Arg Arg Leu Val Glu Gly Asn 
        115                 120                 125             


Pro Asn Trp Leu Gln Gly Glu Pro Pro Arg Met Gln Asp Leu Ile His 
    130                 135                 140                 


Gly Gln Glu Ser Arg Arg Lys Thr Ser Arg Thr Glu Ile Pro Ala Leu 
145                 150                 155                 160 


Leu Val Asn Cys Lys Cys Gln Asp Gln Leu Leu Arg Val Ala Val Asp 
                165                 170                 175     


Thr Gly Thr Gln Tyr Asn Arg Ile Ser Ala Gly Cys Leu Ser Arg Leu 
            180                 185                 190         


Gly Leu Glu Lys Arg Val Leu Lys Ala Ser Ala Gly Asp Leu Ala Pro 
        195                 200                 205             


Gly Pro Pro Thr Gln Val Glu Gln Leu Glu Leu Gln Leu Gly Gln Glu 
    210                 215                 220                 


Thr Val Val Cys Ser Ala Gln Val Val Asp Ala Glu Ser Pro Glu Phe 
225                 230                 235                 240 


Cys Leu Gly Leu Gln Thr Leu Leu Ser Leu Lys Cys Cys Ile Asp Leu 
                245                 250                 255     


Glu His Gly Val Leu Arg Leu Lys Ala Pro Phe Ser Glu Leu Pro Phe 
            260                 265                 270         


Leu Pro Leu Tyr Gln Glu Pro Gly Gln 
        275                 280     


<210>  298
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  298

Met Gln Arg Met Ile Gln Gln Phe Ala Ala Glu Tyr Thr Ser Lys Asn 
1               5                   10                  15      


Ser Ser Thr Gln Asp Pro Ser Gln Pro Asn Ser Thr Lys Asn Gln Ser 
            20                  25                  30          


Leu Pro Lys Ala Ser Pro Val Thr Thr Ser Pro Thr Ala Ala Thr Thr 
        35                  40                  45              


Gln Asn Pro Val Leu Ser Lys Leu Leu Met Ala Asp Gln Asp Ser Pro 
    50                  55                  60                  


Leu Asp Leu Thr Val Arg Lys Ser Gln Ser Glu Pro Ser Glu Gln Asp 
65                  70                  75                  80  


Gly Val Leu Asp Leu Ser Thr Lys Lys Ser Pro Cys Ala Gly Ser Thr 
                85                  90                  95      


Ser Leu Ser His Ser Pro Gly Cys Ser Ser Thr Gln Gly Asn Gly Arg 
            100                 105                 110         


Pro Gly Arg Pro Ser Gln Tyr Arg Pro Asp Gly Leu Arg Ser Gly Asp 
        115                 120                 125             


Gly Val Pro Pro Arg Ser Leu Gln Asp Gly Thr Arg Glu Gly Phe Gly 
    130                 135                 140                 


His Ser Thr Ser Leu Lys Val Pro Leu Ala Arg Ser Leu Gln Ile Ser 
145                 150                 155                 160 


Glu Glu Leu Leu Ser Arg Asn Gln Leu Ser Thr Ala Ala Ser Leu Gly 
                165                 170                 175     


Pro Ser Gly Leu Gln Asn His Gly Gln His Leu Ile Leu Ser Arg Glu 
            180                 185                 190         


Ala Ser Trp Ala Lys Pro His Tyr Glu Phe Asn Leu Ser Arg Met Lys 
        195                 200                 205             


Phe Arg Gly Asn Gly Ala Leu Ser Asn Ile Ser Asp Leu Pro Phe Leu 
    210                 215                 220                 


Ala Glu Asn Ser Ala Phe Pro Lys Met Ala Leu Gln Ala Lys Gln Asp 
225                 230                 235                 240 


Gly Lys Lys Asp Val Ser His Ser Ser Pro Val Asp Leu Lys Ile Pro 
                245                 250                 255     


Gln Val Arg Gly Met Asp Leu Ser Trp Glu Ser Arg Thr Gly Asp Gln 
            260                 265                 270         


Tyr Ser Tyr Ser Ser Leu Val Met Gly Ser Gln Thr Glu Ser Ala Leu 
        275                 280                 285             


Ser Lys Lys Leu Arg Ala Ile Leu Pro Lys Gln Ser Arg Lys Ser Met 
    290                 295                 300                 


Leu Asp Ala Gly Pro Asp Ser Trp Gly Ser Asp Ala Glu Gln Ser Thr 
305                 310                 315                 320 


Ser Gly Gln Pro Tyr Pro Thr Ser Asp Gln Glu Gly Asp Pro Gly Ser 
                325                 330                 335     


Lys Gln Pro Arg Lys Lys Arg Gly Arg Tyr Arg Gln Tyr Asn Ser Glu 
            340                 345                 350         


Ile Leu Glu Glu Ala Ile Ser Val Val Met Ser Gly Lys Met Ser Val 
        355                 360                 365             


Ser Lys Ala Gln Ser Ile Tyr Gly Ile Pro His Ser Thr Leu Glu Tyr 
    370                 375                 380                 


Lys Val Lys Glu Arg Leu Gly Thr Leu Lys Asn Pro Pro Lys Lys Lys 
385                 390                 395                 400 


Met Lys Leu Met Arg Ser Glu Gly Pro Asp Val Ser Val Lys Ile Glu 
                405                 410                 415     


Leu Asp Pro Gln Gly Glu Ala Ala Gln Ser Ala Asn Glu Ser Lys Asn 
            420                 425                 430         


Glu 
    


<210>  299
<211>  2440
<212>  PRT
<213>  Homo sapiens

<400>  299

Met Ser Ser Ser Gly Tyr Pro Pro Asn Gln Gly Ala Phe Ser Thr Glu 
1               5                   10                  15      


Gln Ser Arg Tyr Pro Pro His Ser Val Gln Tyr Thr Phe Pro Asn Thr 
            20                  25                  30          


Arg His Gln Gln Glu Phe Ala Val Pro Asp Tyr Arg Ser Ser His Leu 
        35                  40                  45              


Glu Val Ser Gln Ala Ser Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Leu Arg Arg Arg Pro Ser Leu Leu Ser Glu Phe His Pro Gly Ser Asp 
65                  70                  75                  80  


Arg Pro Gln Glu Arg Arg Thr Ser Tyr Glu Pro Phe His Pro Gly Pro 
                85                  90                  95      


Ser Pro Val Asp His Asp Ser Leu Glu Ser Lys Arg Pro Arg Leu Glu 
            100                 105                 110         


Gln Val Ser Asp Ser His Phe Gln Arg Val Ser Ala Ala Val Leu Pro 
        115                 120                 125             


Leu Val His Pro Leu Pro Glu Gly Leu Arg Ala Ser Ala Asp Ala Lys 
    130                 135                 140                 


Lys Asp Pro Ala Phe Gly Gly Lys His Glu Ala Pro Ser Ser Pro Ile 
145                 150                 155                 160 


Ser Gly Gln Pro Cys Gly Asp Asp Gln Asn Ala Ser Pro Ser Lys Leu 
                165                 170                 175     


Ser Lys Glu Glu Leu Ile Gln Ser Met Asp Arg Val Asp Arg Glu Ile 
            180                 185                 190         


Ala Lys Val Glu Gln Gln Ile Leu Lys Leu Lys Lys Lys Gln Gln Gln 
        195                 200                 205             


Leu Glu Glu Glu Ala Ala Lys Pro Pro Glu Pro Glu Lys Pro Val Ser 
    210                 215                 220                 


Pro Pro Pro Val Glu Gln Lys His Arg Ser Ile Val Gln Ile Ile Tyr 
225                 230                 235                 240 


Asp Glu Asn Arg Lys Lys Ala Glu Glu Ala His Lys Ile Phe Glu Gly 
                245                 250                 255     


Leu Gly Pro Lys Val Glu Leu Pro Leu Tyr Asn Gln Pro Ser Asp Thr 
            260                 265                 270         


Lys Val Tyr His Glu Asn Ile Lys Thr Asn Gln Val Met Arg Lys Lys 
        275                 280                 285             


Leu Ile Leu Phe Phe Lys Arg Arg Asn His Ala Arg Lys Gln Arg Glu 
    290                 295                 300                 


Gln Lys Ile Cys Gln Arg Tyr Asp Gln Leu Met Glu Ala Trp Glu Lys 
305                 310                 315                 320 


Lys Val Asp Arg Ile Glu Asn Asn Pro Arg Arg Lys Ala Lys Glu Ser 
                325                 330                 335     


Lys Thr Arg Glu Tyr Tyr Glu Lys Gln Phe Pro Glu Ile Arg Lys Gln 
            340                 345                 350         


Arg Glu Gln Gln Glu Arg Phe Gln Arg Val Gly Gln Arg Gly Ala Gly 
        355                 360                 365             


Leu Ser Ala Thr Ile Ala Arg Ser Glu His Glu Ile Ser Glu Ile Ile 
    370                 375                 380                 


Asp Gly Leu Ser Glu Gln Glu Asn Asn Glu Lys Gln Met Arg Gln Leu 
385                 390                 395                 400 


Ser Val Ile Pro Pro Met Met Phe Asp Ala Glu Gln Arg Arg Val Lys 
                405                 410                 415     


Phe Ile Asn Met Asn Gly Leu Met Glu Asp Pro Met Lys Val Tyr Lys 
            420                 425                 430         


Asp Arg Gln Phe Met Asn Val Trp Thr Asp His Glu Lys Glu Ile Phe 
        435                 440                 445             


Lys Asp Lys Phe Ile Gln His Pro Lys Asn Phe Gly Leu Ile Ala Ser 
    450                 455                 460                 


Tyr Leu Glu Arg Lys Ser Val Pro Asp Cys Val Leu Tyr Tyr Tyr Leu 
465                 470                 475                 480 


Thr Lys Lys Asn Glu Asn Tyr Lys Ala Leu Val Arg Arg Asn Tyr Gly 
                485                 490                 495     


Lys Arg Arg Gly Arg Asn Gln Gln Ile Ala Arg Pro Ser Gln Glu Glu 
            500                 505                 510         


Lys Val Glu Glu Lys Glu Glu Asp Lys Ala Glu Lys Thr Glu Lys Lys 
        515                 520                 525             


Glu Glu Glu Lys Lys Asp Glu Glu Glu Lys Asp Glu Lys Glu Asp Ser 
    530                 535                 540                 


Lys Glu Asn Thr Lys Glu Lys Asp Lys Ile Asp Gly Thr Ala Glu Glu 
545                 550                 555                 560 


Thr Glu Glu Arg Glu Gln Ala Thr Pro Arg Gly Arg Lys Thr Ala Asn 
                565                 570                 575     


Ser Gln Gly Arg Arg Lys Gly Arg Ile Thr Arg Ser Met Thr Asn Glu 
            580                 585                 590         


Ala Ala Ala Ala Ser Ala Ala Ala Ala Ala Ala Thr Glu Glu Pro Pro 
        595                 600                 605             


Pro Pro Leu Pro Pro Pro Pro Glu Pro Ile Ser Thr Glu Pro Val Glu 
    610                 615                 620                 


Thr Ser Arg Trp Thr Glu Glu Glu Met Glu Val Ala Lys Lys Gly Leu 
625                 630                 635                 640 


Val Glu His Gly Arg Asn Trp Ala Ala Ile Ala Lys Met Val Gly Thr 
                645                 650                 655     


Lys Ser Glu Ala Gln Cys Lys Asn Phe Tyr Phe Asn Tyr Lys Arg Arg 
            660                 665                 670         


His Asn Leu Asp Asn Leu Leu Gln Gln His Lys Gln Lys Thr Ser Arg 
        675                 680                 685             


Lys Pro Arg Glu Glu Arg Asp Val Ser Gln Cys Glu Ser Val Ala Ser 
    690                 695                 700                 


Thr Val Ser Ala Gln Glu Asp Glu Asp Ile Glu Ala Ser Asn Glu Glu 
705                 710                 715                 720 


Glu Asn Pro Glu Asp Ser Glu Val Glu Ala Val Lys Pro Ser Glu Asp 
                725                 730                 735     


Ser Pro Glu Asn Ala Thr Ser Arg Gly Asn Thr Glu Pro Ala Val Glu 
            740                 745                 750         


Leu Glu Pro Thr Thr Glu Thr Ala Pro Ser Thr Ser Pro Ser Leu Ala 
        755                 760                 765             


Val Pro Ser Thr Lys Pro Ala Glu Asp Glu Ser Val Glu Thr Gln Val 
    770                 775                 780                 


Asn Asp Ser Ile Ser Ala Glu Thr Ala Glu Gln Met Asp Val Asp Gln 
785                 790                 795                 800 


Gln Glu His Ser Ala Glu Glu Gly Ser Val Cys Asp Pro Pro Pro Ala 
                805                 810                 815     


Thr Lys Ala Asp Ser Val Asp Val Glu Val Arg Val Pro Glu Asn His 
            820                 825                 830         


Ala Ser Lys Val Glu Gly Asp Asn Thr Lys Glu Arg Asp Leu Asp Arg 
        835                 840                 845             


Ala Ser Glu Lys Val Glu Pro Arg Asp Glu Asp Leu Val Val Ala Gln 
    850                 855                 860                 


Gln Ile Asn Ala Gln Arg Pro Glu Pro Gln Ser Asp Asn Asp Ser Ser 
865                 870                 875                 880 


Ala Thr Cys Ser Ala Asp Glu Asp Val Asp Gly Glu Pro Glu Arg Gln 
                885                 890                 895     


Arg Met Phe Pro Met Asp Ser Lys Pro Ser Leu Leu Asn Pro Thr Gly 
            900                 905                 910         


Ser Ile Leu Val Ser Ser Pro Leu Lys Pro Asn Pro Leu Asp Leu Pro 
        915                 920                 925             


Gln Leu Gln His Arg Ala Ala Val Ile Pro Pro Met Val Ser Cys Thr 
    930                 935                 940                 


Pro Cys Asn Ile Pro Ile Gly Thr Pro Val Ser Gly Tyr Ala Leu Tyr 
945                 950                 955                 960 


Gln Arg His Ile Lys Ala Met His Glu Ser Ala Leu Leu Glu Glu Gln 
                965                 970                 975     


Arg Gln Arg Gln Glu Gln Ile Asp Leu Glu Cys Arg Ser Ser Thr Ser 
            980                 985                 990         


Pro Cys Gly Thr Ser Lys Ser Pro  Asn Arg Glu Trp Glu  Val Leu Gln 
        995                 1000                 1005             


Pro Ala  Pro His Gln Val Ile  Thr Asn Leu Pro Glu  Gly Val Arg 
    1010                 1015                 1020             


Leu Pro  Thr Thr Arg Pro Thr  Arg Pro Pro Pro Pro  Leu Ile Pro 
    1025                 1030                 1035             


Ser Ser  Lys Thr Thr Val Ala  Ser Glu Lys Pro Ser  Phe Ile Met 
    1040                 1045                 1050             


Gly Gly  Ser Ile Ser Gln Gly  Thr Pro Gly Thr Tyr  Leu Thr Ser 
    1055                 1060                 1065             


His Asn  Gln Ala Ser Tyr Thr  Gln Glu Thr Pro Lys  Pro Ser Val 
    1070                 1075                 1080             


Gly Ser  Ile Ser Leu Gly Leu  Pro Arg Gln Gln Glu  Ser Ala Lys 
    1085                 1090                 1095             


Ser Ala  Thr Leu Pro Tyr Ile  Lys Gln Glu Glu Phe  Ser Pro Arg 
    1100                 1105                 1110             


Ser Gln  Asn Ser Gln Pro Glu  Gly Leu Leu Val Arg  Ala Gln His 
    1115                 1120                 1125             


Glu Gly  Val Val Arg Gly Thr  Ala Gly Ala Ile Gln  Glu Gly Ser 
    1130                 1135                 1140             


Ile Thr  Arg Gly Thr Pro Thr  Ser Lys Ile Ser Val  Glu Ser Ile 
    1145                 1150                 1155             


Pro Ser  Leu Arg Gly Ser Ile  Thr Gln Gly Thr Pro  Ala Leu Pro 
    1160                 1165                 1170             


Gln Thr  Gly Ile Pro Thr Glu  Ala Leu Val Lys Gly  Ser Ile Ser 
    1175                 1180                 1185             


Arg Met  Pro Ile Glu Asp Ser  Ser Pro Glu Lys Gly  Arg Glu Glu 
    1190                 1195                 1200             


Ala Ala  Ser Lys Gly His Val  Ile Tyr Glu Gly Lys  Ser Gly His 
    1205                 1210                 1215             


Ile Leu  Ser Tyr Asp Asn Ile  Lys Asn Ala Arg Glu  Gly Thr Arg 
    1220                 1225                 1230             


Ser Pro  Arg Thr Ala His Glu  Ile Ser Leu Lys Arg  Ser Tyr Glu 
    1235                 1240                 1245             


Ser Val  Glu Gly Asn Ile Lys  Gln Gly Met Ser Met  Arg Glu Ser 
    1250                 1255                 1260             


Pro Val  Ser Ala Pro Leu Glu  Gly Leu Ile Cys Arg  Ala Leu Pro 
    1265                 1270                 1275             


Arg Gly  Ser Pro His Ser Asp  Leu Lys Glu Arg Thr  Val Leu Ser 
    1280                 1285                 1290             


Gly Ser  Ile Met Gln Gly Thr  Pro Arg Ala Thr Thr  Glu Ser Phe 
    1295                 1300                 1305             


Glu Asp  Gly Leu Lys Tyr Pro  Lys Gln Ile Lys Arg  Glu Ser Pro 
    1310                 1315                 1320             


Pro Ile  Arg Ala Phe Glu Gly  Ala Ile Thr Lys Gly  Lys Pro Tyr 
    1325                 1330                 1335             


Asp Gly  Ile Thr Thr Ile Lys  Glu Met Gly Arg Ser  Ile His Glu 
    1340                 1345                 1350             


Ile Pro  Arg Gln Asp Ile Leu  Thr Gln Glu Ser Arg  Lys Thr Pro 
    1355                 1360                 1365             


Glu Val  Val Gln Ser Thr Arg  Pro Ile Ile Glu Gly  Ser Ile Ser 
    1370                 1375                 1380             


Gln Gly  Thr Pro Ile Lys Phe  Asp Asn Asn Ser Gly  Gln Ser Ala 
    1385                 1390                 1395             


Ile Lys  His Asn Val Lys Ser  Leu Ile Thr Gly Pro  Ser Lys Leu 
    1400                 1405                 1410             


Ser Arg  Gly Met Pro Pro Leu  Glu Ile Val Pro Glu  Asn Ile Lys 
    1415                 1420                 1425             


Val Val  Glu Arg Gly Lys Tyr  Glu Asp Val Lys Ala  Gly Glu Thr 
    1430                 1435                 1440             


Val Arg  Ser Arg His Thr Ser  Val Val Ser Ser Gly  Pro Ser Val 
    1445                 1450                 1455             


Leu Arg  Ser Thr Leu His Glu  Ala Pro Lys Ala Gln  Leu Ser Pro 
    1460                 1465                 1470             


Gly Ile  Tyr Asp Asp Thr Ser  Ala Arg Arg Thr Pro  Val Ser Tyr 
    1475                 1480                 1485             


Gln Asn  Thr Met Ser Arg Gly  Ser Pro Met Met Asn  Arg Thr Ser 
    1490                 1495                 1500             


Asp Val  Thr Ile Ser Ser Asn  Lys Ser Thr Asn His  Glu Arg Lys 
    1505                 1510                 1515             


Ser Thr  Leu Thr Pro Thr Gln  Arg Glu Ser Ile Pro  Ala Lys Ser 
    1520                 1525                 1530             


Pro Val  Pro Gly Val Asp Pro  Val Val Ser His Ser  Pro Phe Asp 
    1535                 1540                 1545             


Pro His  His Arg Gly Ser Thr  Ala Gly Glu Val Tyr  Arg Ser His 
    1550                 1555                 1560             


Leu Pro  Thr His Leu Asp Pro  Ala Met Pro Phe His  Arg Ala Leu 
    1565                 1570                 1575             


Asp Pro  Ala Ala Ala Ala Tyr  Leu Phe Gln Arg Gln  Leu Ser Pro 
    1580                 1585                 1590             


Thr Pro  Gly Tyr Pro Ser Gln  Tyr Gln Leu Tyr Ala  Met Glu Asn 
    1595                 1600                 1605             


Thr Arg  Gln Thr Ile Leu Asn  Asp Tyr Ile Thr Ser  Gln Gln Met 
    1610                 1615                 1620             


Gln Val  Asn Leu Arg Pro Asp  Val Ala Arg Gly Leu  Ser Pro Arg 
    1625                 1630                 1635             


Glu Gln  Pro Leu Gly Leu Pro  Tyr Pro Ala Thr Arg  Gly Ile Ile 
    1640                 1645                 1650             


Asp Leu  Thr Asn Met Pro Pro  Thr Ile Leu Val Pro  His Pro Gly 
    1655                 1660                 1665             


Gly Thr  Ser Thr Pro Pro Met  Asp Arg Ile Thr Tyr  Ile Pro Gly 
    1670                 1675                 1680             


Thr Gln  Ile Thr Phe Pro Pro  Arg Pro Tyr Asn Ser  Ala Ser Met 
    1685                 1690                 1695             


Ser Pro  Gly His Pro Thr His  Leu Ala Ala Ala Ala  Ser Ala Glu 
    1700                 1705                 1710             


Arg Glu  Arg Glu Arg Glu Arg  Glu Lys Glu Arg Glu  Arg Glu Arg 
    1715                 1720                 1725             


Ile Ala  Ala Ala Ser Ser Asp  Leu Tyr Leu Arg Pro  Gly Ser Glu 
    1730                 1735                 1740             


Gln Pro  Gly Arg Pro Gly Ser  His Gly Tyr Val Arg  Ser Pro Ser 
    1745                 1750                 1755             


Pro Ser  Val Arg Thr Gln Glu  Thr Met Leu Gln Gln  Arg Pro Ser 
    1760                 1765                 1770             


Val Phe  Gln Gly Thr Asn Gly  Thr Ser Val Ile Thr  Pro Leu Asp 
    1775                 1780                 1785             


Pro Thr  Ala Gln Leu Arg Ile  Met Pro Leu Pro Ala  Gly Gly Pro 
    1790                 1795                 1800             


Ser Ile  Ser Gln Gly Leu Pro  Ala Ser Arg Tyr Asn  Thr Ala Ala 
    1805                 1810                 1815             


Asp Ala  Leu Ala Ala Leu Val  Asp Ala Ala Ala Ser  Ala Pro Gln 
    1820                 1825                 1830             


Met Asp  Val Ser Lys Thr Lys  Glu Ser Lys His Glu  Ala Ala Arg 
    1835                 1840                 1845             


Leu Glu  Glu Asn Leu Arg Ser  Arg Ser Ala Ala Val  Ser Glu Gln 
    1850                 1855                 1860             


Gln Gln  Leu Glu Gln Lys Thr  Leu Glu Val Glu Lys  Arg Ser Val 
    1865                 1870                 1875             


Gln Cys  Leu Tyr Thr Ser Ser  Ala Phe Pro Ser Gly  Lys Pro Gln 
    1880                 1885                 1890             


Pro His  Ser Ser Val Val Tyr  Ser Glu Ala Gly Lys  Asp Lys Gly 
    1895                 1900                 1905             


Pro Pro  Pro Lys Ser Arg Tyr  Glu Glu Glu Leu Arg  Thr Arg Gly 
    1910                 1915                 1920             


Lys Thr  Thr Ile Thr Ala Ala  Asn Phe Ile Asp Val  Ile Ile Thr 
    1925                 1930                 1935             


Arg Gln  Ile Ala Ser Asp Lys  Asp Ala Arg Glu Arg  Gly Ser Gln 
    1940                 1945                 1950             


Ser Ser  Asp Ser Ser Ser Ser  Leu Ser Ser His Arg  Tyr Glu Thr 
    1955                 1960                 1965             


Pro Ser  Asp Ala Ile Glu Val  Ile Ser Pro Ala Ser  Ser Pro Ala 
    1970                 1975                 1980             


Pro Pro  Gln Glu Lys Leu Gln  Thr Tyr Gln Pro Glu  Val Val Lys 
    1985                 1990                 1995             


Ala Asn  Gln Ala Glu Asn Asp  Pro Thr Arg Gln Tyr  Glu Gly Pro 
    2000                 2005                 2010             


Leu His  His Tyr Arg Pro Gln  Gln Glu Ser Pro Ser  Pro Gln Gln 
    2015                 2020                 2025             


Gln Leu  Pro Pro Ser Ser Gln  Ala Glu Gly Met Gly  Gln Val Pro 
    2030                 2035                 2040             


Arg Thr  His Arg Leu Ile Thr  Leu Ala Asp His Ile  Cys Gln Ile 
    2045                 2050                 2055             


Ile Thr  Gln Asp Phe Ala Arg  Asn Gln Val Ser Ser  Gln Thr Pro 
    2060                 2065                 2070             


Gln Gln  Pro Pro Thr Ser Thr  Phe Gln Asn Ser Pro  Ser Ala Leu 
    2075                 2080                 2085             


Val Ser  Thr Pro Val Arg Thr  Lys Thr Ser Asn Arg  Tyr Ser Pro 
    2090                 2095                 2100             


Glu Ser  Gln Ala Gln Ser Val  His His Gln Arg Pro  Gly Ser Arg 
    2105                 2110                 2115             


Val Ser  Pro Glu Asn Leu Val  Asp Lys Ser Arg Gly  Ser Arg Pro 
    2120                 2125                 2130             


Gly Lys  Ser Pro Glu Arg Ser  His Val Ser Ser Glu  Pro Tyr Glu 
    2135                 2140                 2145             


Pro Ile  Ser Pro Pro Gln Val  Pro Val Val His Glu  Lys Gln Asp 
    2150                 2155                 2160             


Ser Leu  Leu Leu Leu Ser Gln  Arg Gly Ala Glu Pro  Ala Glu Gln 
    2165                 2170                 2175             


Arg Asn  Asp Ala Arg Ser Pro  Gly Ser Ile Ser Tyr  Leu Pro Ser 
    2180                 2185                 2190             


Phe Phe  Thr Lys Leu Glu Asn  Thr Ser Pro Met Val  Lys Ser Lys 
    2195                 2200                 2205             


Lys Gln  Glu Ile Phe Arg Lys  Leu Asn Ser Ser Gly  Gly Gly Asp 
    2210                 2215                 2220             


Ser Asp  Met Ala Ala Ala Gln  Pro Gly Thr Glu Ile  Phe Asn Leu 
    2225                 2230                 2235             


Pro Ala  Val Thr Thr Ser Gly  Ser Val Ser Ser Arg  Gly His Ser 
    2240                 2245                 2250             


Phe Ala  Asp Pro Ala Ser Asn  Leu Gly Leu Glu Asp  Ile Ile Arg 
    2255                 2260                 2265             


Lys Ala  Leu Met Gly Ser Phe  Asp Asp Lys Val Glu  Asp His Gly 
    2270                 2275                 2280             


Val Val  Met Ser Gln Pro Met  Gly Val Val Pro Gly  Thr Ala Asn 
    2285                 2290                 2295             


Thr Ser  Val Val Thr Ser Gly  Glu Thr Arg Arg Glu  Glu Gly Asp 
    2300                 2305                 2310             


Pro Ser  Pro His Ser Gly Gly  Val Cys Lys Pro Lys  Leu Ile Ser 
    2315                 2320                 2325             


Lys Ser  Asn Ser Arg Lys Ser  Lys Ser Pro Ile Pro  Gly Gln Gly 
    2330                 2335                 2340             


Tyr Leu  Gly Thr Glu Arg Pro  Ser Ser Val Ser Ser  Val His Ser 
    2345                 2350                 2355             


Glu Gly  Asp Tyr His Arg Gln  Thr Pro Gly Trp Ala  Trp Glu Asp 
    2360                 2365                 2370             


Arg Pro  Ser Ser Thr Gly Ser  Thr Gln Phe Pro Tyr  Asn Pro Leu 
    2375                 2380                 2385             


Thr Met  Arg Met Leu Ser Ser  Thr Pro Pro Thr Pro  Ile Ala Cys 
    2390                 2395                 2400             


Ala Pro  Ser Ala Val Asn Gln  Ala Ala Pro His Gln  Gln Asn Arg 
    2405                 2410                 2415             


Ile Trp  Glu Arg Glu Pro Ala  Pro Leu Leu Ser Ala  Gln Tyr Glu 
    2420                 2425                 2430             


Thr Leu  Ser Asp Ser Asp Asp  
    2435                 2440 


<210>  300
<211>  2514
<212>  PRT
<213>  Homo sapiens

<400>  300

Met Ser Gly Ser Thr Gln Pro Val Ala Gln Thr Trp Arg Ala Thr Glu 
1               5                   10                  15      


Pro Arg Tyr Pro Pro His Ser Leu Ser Tyr Pro Val Gln Ile Ala Arg 
            20                  25                  30          


Thr His Thr Asp Val Gly Leu Leu Glu Tyr Gln His His Ser Arg Asp 
        35                  40                  45              


Tyr Ala Ser His Leu Ser Pro Gly Ser Ile Ile Gln Pro Gln Arg Arg 
    50                  55                  60                  


Arg Pro Ser Leu Leu Ser Glu Phe Gln Pro Gly Asn Glu Arg Ser Gln 
65                  70                  75                  80  


Glu Leu His Leu Arg Pro Glu Ser His Ser Tyr Leu Pro Glu Leu Gly 
                85                  90                  95      


Lys Ser Glu Met Glu Phe Ile Glu Ser Lys Arg Pro Arg Leu Glu Leu 
            100                 105                 110         


Leu Pro Asp Pro Leu Leu Arg Pro Ser Pro Leu Leu Ala Thr Gly Gln 
        115                 120                 125             


Pro Ala Gly Ser Glu Asp Leu Thr Lys Asp Arg Ser Leu Thr Gly Lys 
    130                 135                 140                 


Leu Glu Pro Val Ser Pro Pro Ser Pro Pro His Thr Asp Pro Glu Leu 
145                 150                 155                 160 


Glu Leu Val Pro Pro Arg Leu Ser Lys Glu Glu Leu Ile Gln Asn Met 
                165                 170                 175     


Asp Arg Val Asp Arg Glu Ile Thr Met Val Glu Gln Gln Ile Ser Lys 
            180                 185                 190         


Leu Lys Lys Lys Gln Gln Gln Leu Glu Glu Glu Ala Ala Lys Pro Pro 
        195                 200                 205             


Glu Pro Glu Lys Pro Val Ser Pro Pro Pro Ile Glu Ser Lys His Arg 
    210                 215                 220                 


Ser Leu Val Gln Ile Ile Tyr Asp Glu Asn Arg Lys Lys Ala Glu Ala 
225                 230                 235                 240 


Ala His Arg Ile Leu Glu Gly Leu Gly Pro Gln Val Glu Leu Pro Leu 
                245                 250                 255     


Tyr Asn Gln Pro Ser Asp Thr Arg Gln Tyr His Glu Asn Ile Lys Ile 
            260                 265                 270         


Asn Gln Ala Met Arg Lys Lys Leu Ile Leu Tyr Phe Lys Arg Arg Asn 
        275                 280                 285             


His Ala Arg Lys Gln Trp Glu Gln Lys Phe Cys Gln Arg Tyr Asp Gln 
    290                 295                 300                 


Leu Met Glu Ala Trp Glu Lys Lys Val Glu Arg Ile Glu Asn Asn Pro 
305                 310                 315                 320 


Arg Arg Arg Ala Lys Glu Ser Lys Val Arg Glu Tyr Tyr Glu Lys Gln 
                325                 330                 335     


Phe Pro Glu Ile Arg Lys Gln Arg Glu Leu Gln Glu Arg Met Gln Ser 
            340                 345                 350         


Arg Val Gly Gln Arg Gly Ser Gly Leu Ser Met Ser Ala Ala Arg Ser 
        355                 360                 365             


Glu His Glu Val Ser Glu Ile Ile Asp Gly Leu Ser Glu Gln Glu Asn 
    370                 375                 380                 


Leu Glu Lys Gln Met Arg Gln Leu Ala Val Ile Pro Pro Met Leu Tyr 
385                 390                 395                 400 


Asp Ala Asp Gln Gln Arg Ile Lys Phe Ile Asn Met Asn Gly Leu Met 
                405                 410                 415     


Ala Asp Pro Met Lys Val Tyr Lys Asp Arg Gln Val Met Asn Met Trp 
            420                 425                 430         


Ser Glu Gln Glu Lys Glu Thr Phe Arg Glu Lys Phe Met Gln His Pro 
        435                 440                 445             


Lys Asn Phe Gly Leu Ile Ala Ser Phe Leu Glu Arg Lys Thr Val Ala 
    450                 455                 460                 


Glu Cys Val Leu Tyr Tyr Tyr Leu Thr Lys Lys Asn Glu Asn Tyr Lys 
465                 470                 475                 480 


Ser Leu Val Arg Arg Ser Tyr Arg Arg Arg Gly Lys Ser Gln Gln Gln 
                485                 490                 495     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Met 
            500                 505                 510         


Pro Arg Ser Ser Gln Glu Glu Lys Asp Glu Lys Glu Lys Glu Lys Glu 
        515                 520                 525             


Ala Glu Lys Glu Glu Glu Lys Pro Glu Val Glu Asn Asp Lys Glu Asp 
    530                 535                 540                 


Leu Leu Lys Glu Lys Thr Asp Asp Thr Ser Gly Glu Asp Asn Asp Glu 
545                 550                 555                 560 


Lys Glu Ala Val Ala Ser Lys Gly Arg Lys Thr Ala Asn Ser Gln Gly 
                565                 570                 575     


Arg Arg Lys Gly Arg Ile Thr Arg Ser Met Ala Asn Glu Ala Asn Ser 
            580                 585                 590         


Glu Glu Ala Ile Thr Pro Gln Gln Ser Ala Glu Leu Ala Ser Met Glu 
        595                 600                 605             


Leu Asn Glu Ser Ser Arg Trp Thr Glu Glu Glu Met Glu Thr Ala Lys 
    610                 615                 620                 


Lys Gly Leu Leu Glu His Gly Arg Asn Trp Ser Ala Ile Ala Arg Met 
625                 630                 635                 640 


Val Gly Ser Lys Thr Val Ser Gln Cys Lys Asn Phe Tyr Phe Asn Tyr 
                645                 650                 655     


Lys Lys Arg Gln Asn Leu Asp Glu Ile Leu Gln Gln His Lys Leu Lys 
            660                 665                 670         


Met Glu Lys Glu Arg Asn Ala Arg Arg Lys Lys Lys Lys Ala Pro Ala 
        675                 680                 685             


Ala Ala Ser Glu Glu Ala Ala Phe Pro Pro Val Val Glu Asp Glu Glu 
    690                 695                 700                 


Met Glu Ala Ser Gly Val Ser Gly Asn Glu Glu Glu Met Val Glu Glu 
705                 710                 715                 720 


Ala Glu Ala Leu His Ala Ser Gly Asn Glu Val Pro Arg Gly Glu Cys 
                725                 730                 735     


Ser Gly Pro Ala Thr Val Asn Asn Ser Ser Asp Thr Glu Ser Ile Pro 
            740                 745                 750         


Ser Pro His Thr Glu Ala Ala Lys Asp Thr Gly Gln Asn Gly Pro Lys 
        755                 760                 765             


Pro Pro Ala Thr Leu Gly Ala Asp Gly Pro Pro Pro Gly Pro Pro Thr 
    770                 775                 780                 


Pro Pro Pro Glu Asp Ile Pro Ala Pro Thr Glu Pro Thr Pro Ala Ser 
785                 790                 795                 800 


Glu Ala Thr Gly Ala Pro Thr Pro Pro Pro Ala Pro Pro Ser Pro Ser 
                805                 810                 815     


Ala Pro Pro Pro Val Val Pro Lys Glu Glu Lys Glu Glu Glu Thr Ala 
            820                 825                 830         


Ala Ala Pro Pro Val Glu Glu Gly Glu Glu Gln Lys Pro Pro Ala Ala 
        835                 840                 845             


Glu Glu Leu Ala Val Asp Thr Gly Lys Ala Glu Glu Pro Val Lys Ser 
    850                 855                 860                 


Glu Cys Thr Glu Glu Ala Glu Glu Gly Pro Ala Lys Gly Lys Asp Ala 
865                 870                 875                 880 


Glu Ala Ala Glu Ala Thr Ala Glu Gly Ala Leu Lys Ala Glu Lys Lys 
                885                 890                 895     


Glu Gly Gly Ser Gly Arg Ala Thr Thr Ala Lys Ser Ser Gly Ala Pro 
            900                 905                 910         


Gln Asp Ser Asp Ser Ser Ala Thr Cys Ser Ala Asp Glu Val Asp Glu 
        915                 920                 925             


Ala Glu Gly Gly Asp Lys Asn Arg Leu Leu Ser Pro Arg Pro Ser Leu 
    930                 935                 940                 


Leu Thr Pro Thr Gly Asp Pro Arg Ala Asn Ala Ser Pro Gln Lys Pro 
945                 950                 955                 960 


Leu Asp Leu Lys Gln Leu Lys Gln Arg Ala Ala Ala Ile Pro Pro Ile 
                965                 970                 975     


Gln Val Thr Lys Val His Glu Pro Pro Arg Glu Asp Ala Ala Pro Thr 
            980                 985                 990         


Lys Pro Ala Pro Pro Ala Pro Pro  Pro Pro Gln Asn Leu  Gln Pro Glu 
        995                 1000                 1005             


Ser Asp  Ala Pro Gln Gln Pro  Gly Ser Ser Pro Arg  Gly Lys Ser 
    1010                 1015                 1020             


Arg Ser  Pro Ala Pro Pro Ala  Asp Lys Glu Ala Phe  Ala Ala Glu 
    1025                 1030                 1035             


Ala Gln  Lys Leu Pro Gly Asp  Pro Pro Cys Trp Thr  Ser Gly Leu 
    1040                 1045                 1050             


Pro Phe  Pro Val Pro Pro Arg  Glu Val Ile Lys Ala  Ser Pro His 
    1055                 1060                 1065             


Ala Pro  Asp Pro Ser Ala Phe  Ser Tyr Ala Pro Pro  Gly His Pro 
    1070                 1075                 1080             


Leu Pro  Leu Gly Leu His Asp  Thr Ala Arg Pro Val  Leu Pro Arg 
    1085                 1090                 1095             


Pro Pro  Thr Ile Ser Asn Pro  Pro Pro Leu Ile Ser  Ser Ala Lys 
    1100                 1105                 1110             


His Pro  Ser Val Leu Glu Arg  Gln Ile Gly Ala Ile  Ser Gln Gly 
    1115                 1120                 1125             


Met Ser  Val Gln Leu His Val  Pro Tyr Ser Glu His  Ala Lys Ala 
    1130                 1135                 1140             


Pro Val  Gly Pro Val Thr Met  Gly Leu Pro Leu Pro  Met Asp Pro 
    1145                 1150                 1155             


Lys Lys  Leu Ala Pro Phe Ser  Gly Val Lys Gln Glu  Gln Leu Ser 
    1160                 1165                 1170             


Pro Arg  Gly Gln Ala Gly Pro  Pro Glu Ser Leu Gly  Val Pro Thr 
    1175                 1180                 1185             


Ala Gln  Glu Ala Ser Val Leu  Arg Gly Thr Ala Leu  Gly Ser Val 
    1190                 1195                 1200             


Pro Gly  Gly Ser Ile Thr Lys  Gly Ile Pro Ser Thr  Arg Val Pro 
    1205                 1210                 1215             


Ser Asp  Ser Ala Ile Thr Tyr  Arg Gly Ser Ile Thr  His Gly Thr 
    1220                 1225                 1230             


Pro Ala  Asp Val Leu Tyr Lys  Gly Thr Ile Thr Arg  Ile Ile Gly 
    1235                 1240                 1245             


Glu Asp  Ser Pro Ser Arg Leu  Asp Arg Gly Arg Glu  Asp Ser Leu 
    1250                 1255                 1260             


Pro Lys  Gly His Val Ile Tyr  Glu Gly Lys Lys Gly  His Val Leu 
    1265                 1270                 1275             


Ser Tyr  Glu Gly Gly Met Ser  Val Thr Gln Cys Ser  Lys Glu Asp 
    1280                 1285                 1290             


Gly Arg  Ser Ser Ser Gly Pro  Pro His Glu Thr Ala  Ala Pro Lys 
    1295                 1300                 1305             


Arg Thr  Tyr Asp Met Met Glu  Gly Arg Val Gly Arg  Ala Ile Ser 
    1310                 1315                 1320             


Ser Ala  Ser Ile Glu Gly Leu  Met Gly Arg Ala Ile  Pro Pro Glu 
    1325                 1330                 1335             


Arg His  Ser Pro His His Leu  Lys Glu Gln His His  Ile Arg Gly 
    1340                 1345                 1350             


Ser Ile  Thr Gln Gly Ile Pro  Arg Ser Tyr Val Glu  Ala Gln Glu 
    1355                 1360                 1365             


Asp Tyr  Leu Arg Arg Glu Ala  Lys Leu Leu Lys Arg  Glu Gly Thr 
    1370                 1375                 1380             


Pro Pro  Pro Pro Pro Pro Ser  Arg Asp Leu Thr Glu  Ala Tyr Lys 
    1385                 1390                 1395             


Thr Gln  Ala Leu Gly Pro Leu  Lys Leu Lys Pro Ala  His Glu Gly 
    1400                 1405                 1410             


Leu Val  Ala Thr Val Lys Glu  Ala Gly Arg Ser Ile  His Glu Ile 
    1415                 1420                 1425             


Pro Arg  Glu Glu Leu Arg His  Thr Pro Glu Leu Pro  Leu Ala Pro 
    1430                 1435                 1440             


Arg Pro  Leu Lys Glu Gly Ser  Ile Thr Gln Gly Thr  Pro Leu Lys 
    1445                 1450                 1455             


Tyr Asp  Thr Gly Ala Ser Thr  Thr Gly Ser Lys Lys  His Asp Val 
    1460                 1465                 1470             


Arg Ser  Leu Ile Gly Ser Pro  Gly Arg Thr Phe Pro  Pro Val His 
    1475                 1480                 1485             


Pro Leu  Asp Val Met Ala Asp  Ala Arg Ala Leu Glu  Arg Ala Cys 
    1490                 1495                 1500             


Tyr Glu  Glu Ser Leu Lys Ser  Arg Pro Gly Thr Ala  Ser Ser Ser 
    1505                 1510                 1515             


Gly Gly  Ser Ile Ala Arg Gly  Ala Pro Val Ile Val  Pro Glu Leu 
    1520                 1525                 1530             


Gly Lys  Pro Arg Gln Ser Pro  Leu Thr Tyr Glu Asp  His Gly Ala 
    1535                 1540                 1545             


Pro Phe  Ala Gly His Leu Pro  Arg Gly Ser Pro Val  Thr Thr Arg 
    1550                 1555                 1560             


Glu Pro  Thr Pro Arg Leu Gln  Glu Gly Ser Leu Ser  Ser Ser Lys 
    1565                 1570                 1575             


Ala Ser  Gln Asp Arg Lys Leu  Thr Ser Thr Pro Arg  Glu Ile Ala 
    1580                 1585                 1590             


Lys Ser  Pro His Ser Thr Val  Pro Glu His His Pro  His Pro Ile 
    1595                 1600                 1605             


Ser Pro  Tyr Glu His Leu Leu  Arg Gly Val Ser Gly  Val Asp Leu 
    1610                 1615                 1620             


Tyr Arg  Ser His Ile Pro Leu  Ala Phe Asp Pro Thr  Ser Ile Pro 
    1625                 1630                 1635             


Arg Gly  Ile Pro Leu Asp Ala  Ala Ala Ala Tyr Tyr  Leu Pro Arg 
    1640                 1645                 1650             


His Leu  Ala Pro Asn Pro Thr  Tyr Pro His Leu Tyr  Pro Pro Tyr 
    1655                 1660                 1665             


Leu Ile  Arg Gly Tyr Pro Asp  Thr Ala Ala Leu Glu  Asn Arg Gln 
    1670                 1675                 1680             


Thr Ile  Ile Asn Asp Tyr Ile  Thr Ser Gln Gln Met  His His Asn 
    1685                 1690                 1695             


Ala Ala  Thr Ala Met Ala Gln  Arg Ala Asp Met Leu  Arg Gly Leu 
    1700                 1705                 1710             


Ser Pro  Arg Glu Ser Ser Leu  Ala Leu Asn Tyr Ala  Ala Gly Pro 
    1715                 1720                 1725             


Arg Gly  Ile Ile Asp Leu Ser  Gln Val Pro His Leu  Pro Val Leu 
    1730                 1735                 1740             


Val Pro  Pro Thr Pro Gly Thr  Pro Ala Thr Ala Met  Asp Arg Leu 
    1745                 1750                 1755             


Ala Tyr  Leu Pro Thr Ala Pro  Gln Pro Phe Ser Ser  Arg His Ser 
    1760                 1765                 1770             


Ser Ser  Pro Leu Ser Pro Gly  Gly Pro Thr His Leu  Thr Lys Pro 
    1775                 1780                 1785             


Thr Thr  Thr Ser Ser Ser Glu  Arg Glu Arg Asp Arg  Asp Arg Glu 
    1790                 1795                 1800             


Arg Asp  Arg Asp Arg Glu Arg  Glu Lys Ser Ile Leu  Thr Ser Thr 
    1805                 1810                 1815             


Thr Thr  Val Glu His Ala Pro  Ile Trp Arg Pro Gly  Thr Glu Gln 
    1820                 1825                 1830             


Ser Ser  Gly Ser Ser Gly Gly  Gly Gly Gly Ser Ser  Ser Arg Pro 
    1835                 1840                 1845             


Ala Ser  His Ser His Ala His  Gln His Ser Pro Ile  Ser Pro Arg 
    1850                 1855                 1860             


Thr Gln  Asp Ala Leu Gln Gln  Arg Pro Ser Val Leu  His Asn Thr 
    1865                 1870                 1875             


Gly Met  Lys Gly Ile Ile Thr  Ala Val Glu Pro Ser  Thr Pro Thr 
    1880                 1885                 1890             


Val Leu  Arg Ser Thr Ser Thr  Ser Ser Pro Val Arg  Pro Ala Ala 
    1895                 1900                 1905             


Thr Phe  Pro Pro Ala Thr His  Cys Pro Leu Gly Gly  Thr Leu Asp 
    1910                 1915                 1920             


Gly Val  Tyr Pro Thr Leu Met  Glu Pro Val Leu Leu  Pro Lys Glu 
    1925                 1930                 1935             


Ala Pro  Arg Val Ala Arg Pro  Glu Arg Pro Arg Ala  Asp Thr Gly 
    1940                 1945                 1950             


His Ala  Phe Leu Ala Lys Pro  Pro Ala Arg Ser Gly  Leu Glu Pro 
    1955                 1960                 1965             


Ala Ser  Ser Pro Ser Lys Gly  Ser Glu Pro Arg Pro  Leu Val Pro 
    1970                 1975                 1980             


Pro Val  Ser Gly His Ala Thr  Ile Ala Arg Thr Pro  Ala Lys Asn 
    1985                 1990                 1995             


Leu Ala  Pro His His Ala Ser  Pro Asp Pro Pro Ala  Pro Pro Ala 
    2000                 2005                 2010             


Ser Ala  Ser Asp Pro His Arg  Glu Lys Thr Gln Ser  Lys Pro Phe 
    2015                 2020                 2025             


Ser Ile  Gln Glu Leu Glu Leu  Arg Ser Leu Gly Tyr  His Gly Ser 
    2030                 2035                 2040             


Ser Tyr  Ser Pro Glu Gly Val  Glu Pro Val Ser Pro  Val Ser Ser 
    2045                 2050                 2055             


Pro Ser  Leu Thr His Asp Lys  Gly Leu Pro Lys His  Leu Glu Glu 
    2060                 2065                 2070             


Leu Asp  Lys Ser His Leu Glu  Gly Glu Leu Arg Pro  Lys Gln Pro 
    2075                 2080                 2085             


Gly Pro  Val Lys Leu Gly Gly  Glu Ala Ala His Leu  Pro His Leu 
    2090                 2095                 2100             


Arg Pro  Leu Pro Glu Ser Gln  Pro Ser Ser Ser Pro  Leu Leu Gln 
    2105                 2110                 2115             


Thr Ala  Pro Gly Val Lys Gly  His Gln Arg Val Val  Thr Leu Ala 
    2120                 2125                 2130             


Gln His  Ile Ser Glu Val Ile  Thr Gln Asp Tyr Thr  Arg His His 
    2135                 2140                 2145             


Pro Gln  Gln Leu Ser Ala Pro  Leu Pro Ala Pro Leu  Tyr Ser Phe 
    2150                 2155                 2160             


Pro Gly  Ala Ser Cys Pro Val  Leu Asp Leu Arg Arg  Pro Pro Ser 
    2165                 2170                 2175             


Asp Leu  Tyr Leu Pro Pro Pro  Asp His Gly Ala Pro  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  His Ser Glu Gly Gly  Lys Arg Ser Pro Glu  Pro Asn Lys 
    2195                 2200                 2205             


Thr Ser  Val Leu Gly Gly Gly  Glu Asp Gly Ile Glu  Pro Val Ser 
    2210                 2215                 2220             


Pro Pro  Glu Gly Met Thr Glu  Pro Gly His Ser Arg  Ser Ala Val 
    2225                 2230                 2235             


Tyr Pro  Leu Leu Tyr Arg Asp  Gly Glu Gln Thr Glu  Pro Ser Arg 
    2240                 2245                 2250             


Met Gly  Ser Lys Ser Pro Gly  Asn Thr Ser Gln Pro  Pro Ala Phe 
    2255                 2260                 2265             


Phe Ser  Lys Leu Thr Glu Ser  Asn Ser Ala Met Val  Lys Ser Lys 
    2270                 2275                 2280             


Lys Gln  Glu Ile Asn Lys Lys  Leu Asn Thr His Asn  Arg Asn Glu 
    2285                 2290                 2295             


Pro Glu  Tyr Asn Ile Ser Gln  Pro Gly Thr Glu Ile  Phe Asn Met 
    2300                 2305                 2310             


Pro Ala  Ile Thr Gly Thr Gly  Leu Met Thr Tyr Arg  Ser Gln Ala 
    2315                 2320                 2325             


Val Gln  Glu His Ala Ser Thr  Asn Met Gly Leu Glu  Ala Ile Ile 
    2330                 2335                 2340             


Arg Lys  Ala Leu Met Gly Lys  Tyr Asp Gln Trp Glu  Glu Ser Pro 
    2345                 2350                 2355             


Pro Leu  Ser Ala Asn Ala Phe  Asn Pro Leu Asn Ala  Ser Ala Ser 
    2360                 2365                 2370             


Leu Pro  Ala Ala Met Pro Ile  Thr Ala Ala Asp Gly  Arg Ser Asp 
    2375                 2380                 2385             


His Thr  Leu Thr Ser Pro Gly  Gly Gly Gly Lys Ala  Lys Val Ser 
    2390                 2395                 2400             


Gly Arg  Pro Ser Ser Arg Lys  Ala Lys Ser Pro Ala  Pro Gly Leu 
    2405                 2410                 2415             


Ala Ser  Gly Asp Arg Pro Pro  Ser Val Ser Ser Val  His Ser Glu 
    2420                 2425                 2430             


Gly Asp  Cys Asn Arg Arg Thr  Pro Leu Thr Asn Arg  Val Trp Glu 
    2435                 2440                 2445             


Asp Arg  Pro Ser Ser Ala Gly  Ser Thr Pro Phe Pro  Tyr Asn Pro 
    2450                 2455                 2460             


Leu Ile  Met Arg Leu Gln Ala  Gly Val Met Ala Ser  Pro Pro Pro 
    2465                 2470                 2475             


Pro Gly  Leu Pro Ala Gly Ser  Gly Pro Leu Ala Gly  Pro His His 
    2480                 2485                 2490             


Ala Trp  Asp Glu Glu Pro Lys  Pro Leu Leu Cys Ser  Gln Tyr Glu 
    2495                 2500                 2505             


Thr Leu  Ser Asp Ser Glu 
    2510                 


<210>  301
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  301

Met Thr His Gly Glu Glu Leu Gly Ser Asp Val His Gln Asp Ser Ile 
1               5                   10                  15      


Val Leu Thr Tyr Leu Glu Gly Leu Leu Met His Gln Ala Ala Gly Gly 
            20                  25                  30          


Ser Gly Thr Ala Val Asp Lys Lys Ser Ala Gly His Asn Glu Glu Asp 
        35                  40                  45              


Gln Asn Phe Asn Ile Ser Gly Ser Ala Phe Pro Thr Cys Gln Ser Asn 
    50                  55                  60                  


Gly Pro Val Leu Asn Thr His Thr Tyr Gln Gly Ser Gly Met Leu His 
65                  70                  75                  80  


Leu Lys Lys Ala Arg Leu Leu Gln Ser Ser Glu Asp Trp Asn Ala Ala 
                85                  90                  95      


Lys Arg Lys Arg Leu Ser Asp Ser Ile Met Asn Leu Asn Val Lys Lys 
            100                 105                 110         


Glu Ala Leu Leu Ala Gly Met Val Asp Ser Val Pro Lys Gly Lys Gln 
        115                 120                 125             


Asp Ser Thr Leu Leu Ala Ser Leu Leu Gln Ser Phe Ser Ser Arg Leu 
    130                 135                 140                 


Gln Thr Val Ala Leu Ser Gln Gln Ile Arg Gln Ser Leu Lys Glu Gln 
145                 150                 155                 160 


Gly Tyr Ala Leu Ser His Asp Ser Leu Lys Val Glu Lys Asp Leu Arg 
                165                 170                 175     


Cys Tyr Gly Val Ala Ser Ser His Leu Lys Thr Leu Leu Lys Lys Ser 
            180                 185                 190         


Lys Val Lys Asp Gln Lys Pro Asp Thr Asn Leu Pro Asp Val Thr Lys 
        195                 200                 205             


Asn Leu Ile Arg Asp Arg Phe Ala Glu Ser Pro His His Val Gly Gln 
    210                 215                 220                 


Ser Gly Thr Lys Val Met Ser Glu Pro Leu Ser Cys Ala Ala Arg Leu 
225                 230                 235                 240 


Gln Ala Val Ala Ser Met Val Glu Lys Arg Ala Ser Pro Ala Thr Ser 
                245                 250                 255     


Pro Lys Pro Ser Val Ala Cys Ser Gln Leu Ala Leu Leu Leu Ser Ser 
            260                 265                 270         


Glu Ala His Leu Gln Gln Tyr Ser Arg Glu His Ala Leu Lys Thr Gln 
        275                 280                 285             


Asn Ala Asn Gln Ala Ala Ser Glu Arg Leu Ala Ala Met Ala Arg Leu 
    290                 295                 300                 


Gln Glu Asn Gly Gln Lys Asp Val Gly Ser Tyr Gln Leu Pro Lys Gly 
305                 310                 315                 320 


Met Ser Ser His Leu Asn Gly Gln Ala Arg Thr Ser Ser Ser Lys Leu 
                325                 330                 335     


Met Ala Ser Lys Ser Ser Ala Thr Val Phe Gln Asn Pro Met Gly Ile 
            340                 345                 350         


Ile Pro Ser Ser Pro Lys Asn Ala Gly Tyr Lys Asn Ser Leu Glu Arg 
        355                 360                 365             


Asn Asn Ile Lys Gln Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
    370                 375                 380                 


Lys Ser Gln Thr Ile Pro Lys Pro Met Asn Gly His Ser His Ser Glu 
385                 390                 395                 400 


Arg Gly Ser Ile Phe Glu Glu Ser Ser Thr Pro Thr Thr Ile Asp Glu 
                405                 410                 415     


Tyr Ser Asp Asn Asn Pro Ser Phe Thr Asp Asp Ser Ser Gly Asp Glu 
            420                 425                 430         


Ser Ser Tyr Ser Asn Cys Val Pro Ile Asp Leu Ser Cys Lys His Arg 
        435                 440                 445             


Thr Glu Lys Ser Glu Ser Asp Gln Pro Val Ser Leu Asp Asn Phe Thr 
    450                 455                 460                 


Gln Ser Leu Leu Asn Thr Trp Asp Pro Lys Val Pro Asp Val Asp Ile 
465                 470                 475                 480 


Lys Glu Asp Gln Asp Thr Ser Lys Asn Ser Lys Leu Asn Ser His Gln 
                485                 490                 495     


Lys Val Thr Leu Leu Gln Leu Leu Leu Gly His Lys Asn Glu Glu Asn 
            500                 505                 510         


Val Glu Lys Asn Thr Ser Pro Gln Gly Val His Asn Asp Val Ser Lys 
        515                 520                 525             


Phe Asn Thr Gln Asn Tyr Ala Arg Thr Ser Val Ile Glu Ser Pro Ser 
    530                 535                 540                 


Thr Asn Arg Thr Thr Pro Val Ser Thr Pro Pro Leu Leu Thr Ser Ser 
545                 550                 555                 560 


Lys Ala Gly Ser Pro Ile Asn Leu Ser Gln His Ser Leu Val Ile Lys 
                565                 570                 575     


Trp Asn Ser Pro Pro Tyr Val Cys Ser Thr Gln Ser Glu Lys Leu Thr 
            580                 585                 590         


Asn Thr Ala Ser Asn His Ser Met Asp Leu Thr Lys Ser Lys Asp Pro 
        595                 600                 605             


Pro Gly Glu Lys Pro Ala Gln Asn Glu Gly Ala Gln Asn Ser Ala Thr 
    610                 615                 620                 


Phe Ser Ala Ser Lys Leu Leu Gln Asn Leu Ala Gln Cys Gly Met Gln 
625                 630                 635                 640 


Ser Ser Met Ser Val Glu Glu Gln Arg Pro Ser Lys Gln Leu Leu Thr 
                645                 650                 655     


Gly Asn Thr Asp Lys Pro Ile Gly Met Ile Asp Arg Leu Asn Ser Pro 
            660                 665                 670         


Leu Leu Ser Asn Lys Thr Asn Ala Val Glu Glu Asn Lys Ala Phe Ser 
        675                 680                 685             


Ser Gln Pro Thr Gly Pro Glu Pro Gly Leu Ser Gly Ser Glu Ile Glu 
    690                 695                 700                 


Asn Leu Leu Glu Arg Arg Thr Val Leu Gln Leu Leu Leu Gly Asn Pro 
705                 710                 715                 720 


Asn Lys Gly Lys Ser Glu Lys Lys Glu Lys Thr Pro Leu Arg Asp Glu 
                725                 730                 735     


Ser Thr Gln Glu His Ser Glu Arg Ala Leu Ser Glu Gln Ile Leu Met 
            740                 745                 750         


Val Lys Ile Lys Ser Glu Pro Cys Asp Asp Leu Gln Ile Pro Asn Thr 
        755                 760                 765             


Asn Val His Leu Ser His Asp Ala Lys Ser Ala Pro Phe Leu Gly Met 
    770                 775                 780                 


Ala Pro Ala Val Gln Arg Ser Ala Pro Ala Leu Pro Val Ser Glu Asp 
785                 790                 795                 800 


Phe Lys Ser Glu Pro Val Ser Pro Gln Asp Phe Ser Phe Ser Lys Asn 
                805                 810                 815     


Gly Leu Leu Ser Arg Leu Leu Arg Gln Asn Gln Asp Ser Tyr Leu Ala 
            820                 825                 830         


Asp Asp Ser Asp Arg Ser His Arg Asn Asn Glu Met Ala Leu Leu Glu 
        835                 840                 845             


Ser Lys Asn Leu Cys Met Val Pro Lys Lys Arg Lys Leu Tyr Thr Glu 
    850                 855                 860                 


Pro Leu Glu Asn Pro Phe Lys Lys Met Lys Asn Asn Ile Val Asp Ala 
865                 870                 875                 880 


Ala Asn Asn His Ser Ala Pro Glu Val Leu Tyr Gly Ser Leu Leu Asn 
                885                 890                 895     


Gln Glu Glu Leu Lys Phe Ser Arg Asn Asp Leu Glu Phe Lys Tyr Pro 
            900                 905                 910         


Ala Gly His Gly Ser Ala Ser Glu Ser Glu His Arg Ser Trp Ala Arg 
        915                 920                 925             


Glu Ser Lys Ser Phe Asn Val Leu Lys Gln Leu Leu Leu Ser Glu Asn 
    930                 935                 940                 


Cys Val Arg Asp Leu Ser Pro His Arg Ser Asn Ser Val Ala Asp Ser 
945                 950                 955                 960 


Lys Lys Lys Gly His Lys Asn Asn Val Thr Asn Ser Lys Pro Glu Phe 
                965                 970                 975     


Ser Ile Ser Ser Leu Asn Gly Leu Met Tyr Ser Ser Thr Gln Pro Ser 
            980                 985                 990         


Ser Cys Met Asp Asn Arg Thr Phe  Ser Tyr Pro Gly Val  Val Lys Thr 
        995                 1000                 1005             


Pro Val  Ser Pro Thr Phe Pro  Glu His Leu Gly Cys  Ala Gly Ser 
    1010                 1015                 1020             


Arg Pro  Glu Ser Gly Leu Leu  Asn Gly Cys Ser Met  Pro Ser Glu 
    1025                 1030                 1035             


Lys Gly  Pro Ile Lys Trp Val  Ile Thr Asp Ala Glu  Lys Asn Glu 
    1040                 1045                 1050             


Tyr Glu  Lys Asp Ser Pro Arg  Leu Thr Lys Thr Asn  Pro Ile Leu 
    1055                 1060                 1065             


Tyr Tyr  Met Leu Gln Lys Gly  Gly Asn Ser Val Thr  Ser Arg Glu 
    1070                 1075                 1080             


Thr Gln  Asp Lys Asp Ile Trp  Arg Glu Ala Ser Ser  Ala Glu Ser 
    1085                 1090                 1095             


Val Ser  Gln Val Thr Ala Lys  Glu Glu Leu Leu Pro  Thr Ala Glu 
    1100                 1105                 1110             


Thr Lys  Ala Ser Phe Phe Asn  Leu Arg Ser Pro Tyr  Asn Ser His 
    1115                 1120                 1125             


Met Gly  Asn Asn Ala Ser Arg  Pro His Ser Ala Asn  Gly Glu Val 
    1130                 1135                 1140             


Tyr Gly  Leu Leu Gly Ser Val  Leu Thr Ile Lys Lys  Glu Ser Glu 
    1145                 1150                 1155             


<210>  302
<211>  2080
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Ser Ser Ser Pro Ser Arg Ser Ala Ala Asp Ile Tyr Ile Arg Glu 
1               5                   10                  15      


Tyr Phe His Ser His Val Ser Gly Gly His Pro Glu Ala Thr Pro Leu 
            20                  25                  30          


Arg Val Met Tyr Thr Asp Arg Pro Leu Ser Gln Thr Asp Pro Val Thr 
        35                  40                  45              


Leu Gln Tyr Cys Cys Leu Thr Asp Asp Arg Gln Ala Phe Arg Pro Pro 
    50                  55                  60                  


Thr Arg Ala Glu Leu Ala Arg His Arg Val Val Val Thr Thr Thr Ser 
65                  70                  75                  80  


Gln Ala Arg Glu Leu Arg Val Pro Val Gly Phe Phe Ser His Ile Leu 
                85                  90                  95      


Ile Asp Glu Ala Ala Gln Met Leu Glu Cys Glu Ala Leu Thr Pro Leu 
            100                 105                 110         


Ala Tyr Ala Ser His Gly Thr Arg Leu Val Leu Ala Gly Asp His Met 
        115                 120                 125             


Gln Val Thr Pro Arg Leu Phe Ser Val Ala Arg Ala Arg Ala Ala Glu 
    130                 135                 140                 


His Thr Leu Leu His Arg Leu Phe Leu Cys Tyr Gln Gln Glu Thr His 
145                 150                 155                 160 


Glu Val Ala Arg Gln Ser Arg Leu Val Phe His Glu Asn Tyr Arg Cys 
                165                 170                 175     


Thr Asp Ala Ile Val Ser Phe Ile Ser Arg His Phe Tyr Val Ala Lys 
            180                 185                 190         


Gly Asn Pro Ile His Ala Arg Gly Lys Val Pro Pro His Pro Arg His 
        195                 200                 205             


Tyr Pro Leu Met Phe Cys His Val Ala Gly Ser Pro Asp Arg Asp Met 
    210                 215                 220                 


Ser Met Ala Ser Trp Leu Asn Leu Ala Glu Ile Ala Gln Val Val Glu 
225                 230                 235                 240 


Lys Val Gln Glu Ala Tyr Asn Thr Trp Pro Ser Cys Trp Gly Gly Arg 
                245                 250                 255     


Glu Gln Arg Cys Ile Cys Val Val Ser His Gly Ala Gln Val Ser Ala 
            260                 265                 270         


Leu Arg Gln Glu Leu Arg Arg Arg Asp Leu Gly Gln Val Ser Val Gly 
        275                 280                 285             


Ser Phe Glu Ile Leu Pro Gly Arg Gln Phe Arg Val Val Val Leu Ser 
    290                 295                 300                 


Thr Val His Thr Cys Gln Ser Leu Leu Ser Pro Gly Ala Leu Ala Pro 
305                 310                 315                 320 


Glu Phe Phe Thr Asp Ala Arg Val Leu Asn Thr Val Leu Thr Arg Ala 
                325                 330                 335     


Gln Ser Gln Leu Val Val Val Gly Asp Ala Val Ala Leu Cys Ser Phe 
            340                 345                 350         


Gly Ala Cys Gly Lys Leu Trp Glu Ser Phe Ile Arg Glu Cys Val Glu 
        355                 360                 365             


Arg His Ser Val Cys Pro Glu Gly Leu Ser Met Glu Gln Val Glu Gln 
    370                 375                 380                 


Gly Val Ala Gln Arg Arg Arg Trp Pro Pro Arg Gly Thr Gln Ala Gly 
385                 390                 395                 400 


Ala Ala Gly Asn Trp Glu Ala Ala Pro Glu Pro Val Gly Asp Leu Ala 
                405                 410                 415     


Glu Glu Gln Ala Ala Val Val Thr Ala Met Val Lys Ala Glu Pro Gly 
            420                 425                 430         


Asp Glu Ala Leu Ser Pro Ala Ser Arg Asp Ile Thr Ala Thr Thr Ala 
        435                 440                 445             


Gln Thr Glu Ala Ala Ala Ala Pro Ala Gly Asp Ala Val Lys Glu Asp 
    450                 455                 460                 


Val Val Pro Gly Ala Cys Ala Ala Gly Ala Ala Ala Ala Ala Gly Val 
465                 470                 475                 480 


Glu Ser Thr Glu Ala Glu Asp Ala Glu Ala Asp Phe Trp Pro Trp Asp 
                485                 490                 495     


Gly Glu Leu Asn Ala Asp Asp Ala Ile Leu Arg Glu Leu Leu Asp Glu 
            500                 505                 510         


Ser Gln Lys Val Met Val Thr Val Gly Glu Asp Gly Leu Leu Asp Thr 
        515                 520                 525             


Val Ala Arg Pro Glu Ser Leu Gln Gln Ala Arg Leu Tyr Glu Asn Leu 
    530                 535                 540                 


Pro Pro Ala Ala Leu Arg Lys Leu Leu His Ala Glu Pro Glu Arg Tyr 
545                 550                 555                 560 


Arg His Cys Ser Phe Val Pro Glu Thr Phe Glu Arg Ala Ser Ala Ile 
                565                 570                 575     


Pro Leu Asp Asp Ala Ser Ser Gly Pro Ile Gln Val Arg Gly Arg Leu 
            580                 585                 590         


Asp Cys Gly Met Ala Phe Ala Gly Asp Glu Val Leu Val Gln Leu Leu 
        595                 600                 605             


Ser Gly Asp Lys Ala Pro Glu Gly Arg Leu Arg Gly Arg Val Leu Gly 
    610                 615                 620                 


Val Leu Lys Arg Lys Arg His Glu Leu Ala Phe Val Cys Arg Met Asp 
625                 630                 635                 640 


Thr Trp Asp Pro Arg Ile Met Val Pro Ile Asn Gly Ser Val Thr Lys 
                645                 650                 655     


Ile Phe Val Ala Glu Leu Lys Asp Pro Ser Gln Val Pro Ile Tyr Ser 
            660                 665                 670         


Leu Arg Lys Gly Arg Leu Gln Arg Val Gly Leu Glu Arg Leu Thr Ala 
        675                 680                 685             


Glu Ala Arg His Ser Arg Leu Phe Trp Val Gln Ile Val Leu Trp Arg 
    690                 695                 700                 


Gln Gly Phe Tyr Tyr Pro Leu Gly Ile Val Arg Glu Val Leu Pro Glu 
705                 710                 715                 720 


Ala Ser Thr Trp Glu Gln Gly Leu Arg Ile Leu Gly Leu Glu Tyr Ser 
                725                 730                 735     


Leu Arg Val Pro Pro Ser Asp Gln Ala Thr Ile Thr Lys Val Leu Gln 
            740                 745                 750         


Lys Tyr His Thr Glu Leu Gly Arg Val Ala Gly Arg Arg Glu Asp Cys 
        755                 760                 765             


Arg Ala Phe Leu Thr Phe Thr Val Asp Pro Gln Gly Ala Cys Asn Leu 
    770                 775                 780                 


Asp Asp Ala Leu Ser Val Arg Asp Leu Gly Pro Arg Cys Glu Val Ala 
785                 790                 795                 800 


Val His Ile Thr Asp Val Ala Ser Phe Val Pro Arg Asp Gly Val Leu 
                805                 810                 815     


Asp Val Glu Ala Arg Arg Gln Gly Ala Ala Phe Tyr Ala Pro Gly Arg 
            820                 825                 830         


Glu Pro Val Pro Met Leu Pro Ala Ser Leu Cys Gln Asp Val Leu Ser 
        835                 840                 845             


Leu Leu Pro Gly Arg Asp Arg Leu Ala Ile Ser Leu Phe Leu Thr Met 
    850                 855                 860                 


Glu Lys Ala Ser Gly Gln Leu Lys Ser Leu Arg Phe Ala Pro Ser Val 
865                 870                 875                 880 


Val Gln Ser Asp Arg Gln Leu Ser Tyr Glu Glu Ala Glu Glu Val Ile 
                885                 890                 895     


Arg Gln His Pro Gly Ala Gly Arg Glu Leu Pro Ala Arg Leu Asp Ser 
            900                 905                 910         


Val Asp Ala Cys Val Val Ala Ala Cys Tyr Phe Ser Arg Leu Leu Arg 
        915                 920                 925             


Arg His Arg Leu Arg Ser Asp Cys Phe Tyr Glu Gln Pro Asp Glu Asp 
    930                 935                 940                 


Gly Thr Leu Gly Phe Arg Ala Ala His Ile Met Val Lys Glu Tyr Met 
945                 950                 955                 960 


Ile Gln Phe Asn Arg Leu Val Ala Glu Phe Leu Val Gly Ser Glu Cys 
                965                 970                 975     


Thr Arg Thr Val Thr Pro Leu Arg Trp Gln Pro Ala Pro Arg Ser Gln 
            980                 985                 990         


Gln Leu Lys Ala Leu Cys Glu Lys  His Gly Asp Arg Val  Pro Leu Ser 
        995                 1000                 1005             


Leu His  Leu Gly His His Leu  His Gly Gly Gly Gly  Ser Pro Pro 
    1010                 1015                 1020             


Asp Thr  Arg Leu His Leu Leu  Ala Ser Leu Trp Lys  Gln Val Gln 
    1025                 1030                 1035             


Phe Ala  Ala Arg Thr Gln Asp  Tyr Glu Gln Met Val  Asp Leu Val 
    1040                 1045                 1050             


Thr Thr  Asp Asp Met His Pro  Phe Leu Ala Pro Ala  Gly Arg Asp 
    1055                 1060                 1065             


Leu Arg  Lys Ala Leu Glu Arg  Ser Ala Phe Gly Arg  Cys Ala Arg 
    1070                 1075                 1080             


Gly His  Gln Gln Gln Gly Gly  His Tyr Ser Leu Gln  Val Asp Trp 
    1085                 1090                 1095             


Tyr Thr  Trp Ala Thr Ser Pro  Ile Arg Arg Tyr Leu  Asp Val Val 
    1100                 1105                 1110             


Leu Gln  Arg Gln Ile Leu Leu  Ala Leu Gly His Gly  Gly Ser Ala 
    1115                 1120                 1125             


Tyr Ser  Ala Arg Asp Ile Asp  Gly Leu Cys Gln Ala  Phe Ser Leu 
    1130                 1135                 1140             


Gln His  Ala Leu Ala Gln Ser  Tyr Gln Arg Arg Ala  Arg Ser Leu 
    1145                 1150                 1155             


His Leu  Ala Val Gln Leu Lys  Ala Gln Pro Leu Asp  Lys Leu Gly 
    1160                 1165                 1170             


Phe Val  Val Asp Val Glu Ala  Gly Ser Arg Cys Phe  Arg Leu Leu 
    1175                 1180                 1185             


Phe Pro  Ser Asn Arg Glu Thr  Leu Pro Asp Pro Cys  Pro Val Pro 
    1190                 1195                 1200             


Tyr Gly  Ser Leu Gln Leu Ala  Glu His Pro His Ala  Leu Ala Gly 
    1205                 1210                 1215             


Arg Pro  Gly Leu Arg Leu Leu  Trp Arg Arg Arg Val  Tyr Ser Ala 
    1220                 1225                 1230             


Gln Gly  Ser Ser Pro Pro Leu  Pro Leu Pro Gly Thr  Val Pro Asp 
    1235                 1240                 1245             


Pro His  Thr Leu Ala Val Glu  Thr Ala Leu Trp Lys  Gln Leu Leu 
    1250                 1255                 1260             


Glu Leu  Val Glu Leu Gln Arg  Trp Pro Glu Ala Ala  Ala Leu Ile 
    1265                 1270                 1275             


Gln Glu  Lys Gly Glu Ala Ser  Gln Arg Arg Glu Leu  Val Gln Val 
    1280                 1285                 1290             


Gln Arg  Ser His Cys Gly His  Phe Leu Glu Val Ala  Arg Glu Leu 
    1295                 1300                 1305             


Gly Ser  Gly Asp Thr Leu Gln  Val Gln Leu Gly Thr  Ser Leu Gln 
    1310                 1315                 1320             


His Gly  Phe Leu Val Pro Ser  Pro Gln Leu Trp Thr  Val Ala Pro 
    1325                 1330                 1335             


Gly Phe  Ser Leu Cys Leu Glu  His Val Glu Arg Pro  Gly Asp Cys 
    1340                 1345                 1350             


Phe Ser  Gly Arg Val Tyr Arg  Ala Pro Arg Asp Arg  Tyr Arg Asp 
    1355                 1360                 1365             


Val Asp  Glu Tyr Ala Cys Val  Trp Glu Pro Phe Cys  Ala Leu Glu 
    1370                 1375                 1380             


Ser Ala  Thr Gly Ala Val Ala  Glu Asn Asp Ser Val  Thr Leu Gln 
    1385                 1390                 1395             


His Leu  Ser Val Ser Trp Glu  Ala Ser Arg Thr Pro  Gln Gly Gln 
    1400                 1405                 1410             


Leu Gln  Gly Ala Phe Arg Leu  Glu Ala Ala Phe Leu  Glu Glu Asn 
    1415                 1420                 1425             


Cys Ala  Asp Ile Asn Phe Ser  Cys Cys Tyr Leu Cys  Ile Arg Leu 
    1430                 1435                 1440             


Glu Gly  Leu Pro Ala Pro Thr  Ala Ser Pro Arg Pro  Gly Pro Ser 
    1445                 1450                 1455             


Ser Leu  Gly Pro Gly Leu Asn  Val Asp Pro Gly Thr  Tyr Thr Trp 
    1460                 1465                 1470             


Val Ala  His Gly Gln Thr Gln  Asp Trp Asp Gln Glu  Arg Arg Ala 
    1475                 1480                 1485             


Asp Arg  Gln Glu Ala Pro Arg  Arg Val His Leu Phe  Val His His 
    1490                 1495                 1500             


Met Gly  Met Glu Lys Val Pro  Glu Glu Val Leu Arg  Pro Gly Thr 
    1505                 1510                 1515             


Leu Phe  Thr Val Glu Leu Leu  Pro Lys Gln Leu Pro  Asp Leu Arg 
    1520                 1525                 1530             


Lys Glu  Glu Ala Val Arg Gly  Leu Glu Glu Ala Ser  Pro Leu Val 
    1535                 1540                 1545             


Thr Ser  Ile Ala Leu Gly Arg  Pro Val Pro Gln Pro  Leu Cys Arg 
    1550                 1555                 1560             


Val Ile  Pro Ser Arg Phe Leu  Glu Arg Gln Thr Tyr  Asn Ile Pro 
    1565                 1570                 1575             


Gly Gly  Arg His Lys Leu Asn  Pro Ser Gln Asn Val  Ala Val Arg 
    1580                 1585                 1590             


Glu Ala  Leu Glu Lys Pro Phe  Thr Val Ile Gln Gly  Pro Pro Gly 
    1595                 1600                 1605             


Thr Gly  Lys Thr Ile Val Gly  Leu His Ile Val Phe  Trp Phe His 
    1610                 1615                 1620             


Lys Ser  Asn Gln Glu Gln Val  Gln Pro Gly Gly Pro  Pro Arg Gly 
    1625                 1630                 1635             


Glu Lys  Arg Leu Gly Gly Pro  Cys Ile Leu Tyr Cys  Gly Pro Ser 
    1640                 1645                 1650             


Asn Lys  Ser Val Asp Val Leu  Ala Gly Leu Leu Leu  Arg Arg Met 
    1655                 1660                 1665             


Glu Leu  Lys Pro Leu Arg Val  Tyr Ser Glu Gln Ala  Glu Ala Ser 
    1670                 1675                 1680             


Glu Phe  Pro Val Pro Arg Val  Gly Ser Arg Lys Leu  Leu Arg Lys 
    1685                 1690                 1695             


Ser Pro  Arg Glu Gly Arg Pro  Asn Gln Ser Leu Arg  Ser Ile Thr 
    1700                 1705                 1710             


Leu His  His Arg Ile Arg Gln  Ala Pro Asn Pro Tyr  Ser Ser Glu 
    1715                 1720                 1725             


Ile Lys  Ala Phe Asp Thr Arg  Leu Gln Arg Gly Glu  Leu Phe Ser 
    1730                 1735                 1740             


Arg Glu  Asp Leu Val Trp Tyr  Lys Lys Val Leu Trp  Glu Ala Arg 
    1745                 1750                 1755             


Lys Phe  Glu Leu Asp Arg His  Glu Val Ile Leu Cys  Thr Cys Ser 
    1760                 1765                 1770             


Cys Ala  Ala Ser Ala Ser Leu  Lys Ile Leu Asp Val  Arg Gln Ile 
    1775                 1780                 1785             


Leu Val  Asp Glu Ala Gly Met  Ala Thr Glu Pro Glu  Thr Leu Ile 
    1790                 1795                 1800             


Pro Leu  Val Gln Phe Pro Gln  Ala Glu Lys Val Val  Leu Leu Gly 
    1805                 1810                 1815             


Asp His  Lys Gln Leu Arg Pro  Val Val Lys Asn Glu  Arg Leu Gln 
    1820                 1825                 1830             


Asn Leu  Gly Leu Asp Arg Ser  Leu Phe Glu Arg Tyr  His Glu Asp 
    1835                 1840                 1845             


Ala His  Met Leu Asp Thr Gln  Tyr Arg Met His Glu  Gly Ile Cys 
    1850                 1855                 1860             


Ala Phe  Pro Ser Val Ala Phe  Tyr Lys Ser Lys Leu  Lys Thr Trp 
    1865                 1870                 1875             


Gln Gly  Leu Arg Arg Pro Pro  Ser Val Leu Gly His  Ala Gly Lys 
    1880                 1885                 1890             


Glu Ser  Cys Pro Val Ile Phe  Gly His Val Gln Gly  His Glu Arg 
    1895                 1900                 1905             


Ser Leu  Leu Val Ser Thr Asp  Glu Gly Asn Glu Asn  Ser Lys Ala 
    1910                 1915                 1920             


Asn Leu  Glu Glu Val Ala Glu  Val Val Arg Ile Thr  Lys Gln Leu 
    1925                 1930                 1935             


Thr Leu  Gly Arg Thr Val Glu  Pro Gln Asp Ile Ala  Val Leu Thr 
    1940                 1945                 1950             


Pro Tyr  Asn Ala Gln Ala Ser  Glu Ile Ser Lys Ala  Leu Arg Arg 
    1955                 1960                 1965             


Glu Gly  Ile Ala Gly Val Ala  Val Ser Ser Ile Thr  Lys Ser Gln 
    1970                 1975                 1980             


Gly Ser  Glu Trp Arg Tyr Val  Leu Val Ser Thr Val  Arg Thr Cys 
    1985                 1990                 1995             


Ala Lys  Ser Asp Leu Asp Gln  Arg Pro Thr Lys Ser  Trp Leu Lys 
    2000                 2005                 2010             


Lys Phe  Leu Gly Phe Val Val  Asp Pro Asn Gln Val  Asn Val Ala 
    2015                 2020                 2025             


Val Thr  Arg Ala Gln Glu Gly  Leu Cys Leu Ile Gly  Asp His Leu 
    2030                 2035                 2040             


Leu Leu  Arg Cys Cys Pro Leu  Trp Arg Ser Leu Leu  Asp Phe Cys 
    2045                 2050                 2055             


Glu Ala  Gln Gln Thr Leu Val  Pro Ala Gly Gln Val  Arg Val Cys 
    2060                 2065                 2070             


Arg Arg  Pro Thr Met Pro Ser  
    2075                 2080 


<210>  303
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  304
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  304

Met Asp Ser Tyr Leu Leu Met Trp Gly Leu Leu Thr Phe Ile Met Val 
1               5                   10                  15      


Pro Gly Cys Gln Ala Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro 
            20                  25                  30          


His Ala Thr Phe Lys Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn 
        35                  40                  45              


Cys Glu Cys Lys Arg Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr 
    50                  55                  60                  


Met Leu Cys Thr Gly Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys 
65                  70                  75                  80  


Gln Cys Thr Ser Ser Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro 
                85                  90                  95      


Gln Pro Glu Glu Gln Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro 
            100                 105                 110         


Met Gln Pro Val Asp Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro 
        115                 120                 125             


Pro Pro Trp Glu Asn Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val 
    130                 135                 140                 


Gly Gln Met Val Tyr Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His 
145                 150                 155                 160 


Arg Gly Pro Ala Glu Ser Val Cys Lys Met Thr His Gly Lys Thr Arg 
                165                 170                 175     


Trp Thr Gln Pro Gln Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln 
            180                 185                 190         


Phe Pro Gly Glu Glu Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu 
        195                 200                 205             


Ser Glu Thr Ser Cys Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr 
    210                 215                 220                 


Glu Met Ala Ala Thr Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln 
225                 230                 235                 240 


Val Ala Val Ala Gly Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu 
                245                 250                 255     


Ser Gly Leu Thr Trp Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
            260                 265                 270         


<210>  305
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Ala Ala Pro Ala Leu Ser Trp Arg Leu Pro Leu Leu Ile Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ala Thr Ser Trp Ala Ser Ala Ala Val Asn Gly Thr Ser 
            20                  25                  30          


Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn Ile Ser Cys Val Trp 
        35                  40                  45              


Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys Gln Val His Ala Trp 
    50                  55                  60                  


Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu Leu Leu Pro Val Ser 
65                  70                  75                  80  


Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly Ala Pro Asp Ser Gln 
                85                  90                  95      


Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg Val Leu Cys Arg Glu 
            100                 105                 110         


Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp Phe Lys Pro Phe Glu 
        115                 120                 125             


Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln Val Val His Val Glu 
    130                 135                 140                 


Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser Gln Ala Ser His Tyr 
145                 150                 155                 160 


Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr Leu Ser Pro Gly His 
                165                 170                 175     


Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys Gln Lys Gln Glu Trp 
            180                 185                 190         


Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln Tyr Glu Phe Gln Val 
        195                 200                 205             


Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr Trp Ser Pro Trp Ser 
    210                 215                 220                 


Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala Leu Gly Lys Asp Thr 
225                 230                 235                 240 


Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
                245                 250                 255     


Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys Arg Asn Thr Gly Pro 
            260                 265                 270         


Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro Asp Pro Ser Lys Phe 
        275                 280                 285             


Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp Val Gln Lys Trp Leu 
    290                 295                 300                 


Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro Gly Gly Leu Ala Pro 
305                 310                 315                 320 


Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp Lys Val Thr Gln Leu 
                325                 330                 335     


Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala Ser Leu Ser Ser Asn 
            340                 345                 350         


His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe His 
        355                 360                 365             


Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr Tyr 
    370                 375                 380                 


Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala Pro 
385                 390                 395                 400 


Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp Asp 
                405                 410                 415     


Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser Pro 
            420                 425                 430         


Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser 
        435                 440                 445             


Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro 
    450                 455                 460                 


Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro 
465                 470                 475                 480 


Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala 
                485                 490                 495     


Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro 
            500                 505                 510         


Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg 
        515                 520                 525             


Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly 
    530                 535                 540                 


Gln Asp Pro Thr His Leu Val 
545                 550     


<210>  306
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  306

Met Leu Lys Pro Ser Leu Pro Phe Thr Ser Leu Leu Phe Leu Gln Leu 
1               5                   10                  15      


Pro Leu Leu Gly Val Gly Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly 
            20                  25                  30          


Asn Glu Asp Thr Thr Ala Asp Phe Phe Leu Thr Thr Met Pro Thr Asp 
        35                  40                  45              


Ser Leu Ser Val Ser Thr Leu Pro Leu Pro Glu Val Gln Cys Phe Val 
    50                  55                  60                  


Phe Asn Val Glu Tyr Met Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro 
65                  70                  75                  80  


Gln Pro Thr Asn Leu Thr Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn 
                85                  90                  95      


Asp Lys Val Gln Lys Cys Ser His Tyr Leu Phe Ser Glu Glu Ile Thr 
            100                 105                 110         


Ser Gly Cys Gln Leu Gln Lys Lys Glu Ile His Leu Tyr Gln Thr Phe 
        115                 120                 125             


Val Val Gln Leu Gln Asp Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln 
    130                 135                 140                 


Met Leu Lys Leu Gln Asn Leu Val Ile Pro Trp Ala Pro Glu Asn Leu 
145                 150                 155                 160 


Thr Leu His Lys Leu Ser Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn 
                165                 170                 175     


Arg Phe Leu Asn His Cys Leu Glu His Leu Val Gln Tyr Arg Thr Asp 
            180                 185                 190         


Trp Asp His Ser Trp Thr Glu Gln Ser Val Asp Tyr Arg His Lys Phe 
        195                 200                 205             


Ser Leu Pro Ser Val Asp Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg 
    210                 215                 220                 


Ser Arg Phe Asn Pro Leu Cys Gly Ser Ala Gln His Trp Ser Glu Trp 
225                 230                 235                 240 


Ser His Pro Ile His Trp Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe 
                245                 250                 255     


Leu Phe Ala Leu Glu Ala Val Val Ile Ser Val Gly Ser Met Gly Leu 
            260                 265                 270         


Ile Ile Ser Leu Leu Cys Val Tyr Phe Trp Leu Glu Arg Thr Met Pro 
        275                 280                 285             


Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu Val Thr Glu Tyr His 
    290                 295                 300                 


Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys Gly Leu Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu Val Ser Glu Ile Pro 
                325                 330                 335     


Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn 
            340                 345                 350         


Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu 
        355                 360                 365             


Thr 
    


<210>  307
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  308
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Thr Ile Leu Gly Thr Thr Phe Gly Met Val Phe Ser Leu Leu Gln 
1               5                   10                  15      


Val Val Ser Gly Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
            20                  25                  30          


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
        35                  40                  45              


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
    50                  55                  60                  


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
65                  70                  75                  80  


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
                85                  90                  95      


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
            100                 105                 110         


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
        115                 120                 125             


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
    130                 135                 140                 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
145                 150                 155                 160 


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
                165                 170                 175     


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
            180                 185                 190         


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
        195                 200                 205             


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
    210                 215                 220                 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
225                 230                 235                 240 


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
                245                 250                 255     


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
            260                 265                 270         


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
        275                 280                 285             


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
    290                 295                 300                 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
305                 310                 315                 320 


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
                325                 330                 335     


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
            340                 345                 350         


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
        355                 360                 365             


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
    370                 375                 380                 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
385                 390                 395                 400 


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
                405                 410                 415     


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
            420                 425                 430         


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
        435                 440                 445             


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
    450                 455                 


<210>  309
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Gly Leu Gly Arg Cys Ile Trp Glu Gly Trp Thr Leu Glu Ser Glu 
1               5                   10                  15      


Ala Leu Arg Arg Asp Met Gly Thr Trp Leu Leu Ala Cys Ile Cys Ile 
            20                  25                  30          


Cys Thr Cys Val Cys Leu Gly Val Ser Val Thr Gly Glu Gly Gln Gly 
        35                  40                  45              


Pro Arg Ser Arg Thr Phe Thr Cys Leu Thr Asn Asn Ile Leu Arg Ile 
    50                  55                  60                  


Asp Cys His Trp Ser Ala Pro Glu Leu Gly Gln Gly Ser Ser Pro Trp 
65                  70                  75                  80  


Leu Leu Phe Thr Ser Asn Gln Ala Pro Gly Gly Thr His Lys Cys Ile 
                85                  90                  95      


Leu Arg Gly Ser Glu Cys Thr Val Val Leu Pro Pro Glu Ala Val Leu 
            100                 105                 110         


Val Pro Ser Asp Asn Phe Thr Ile Thr Phe His His Cys Met Ser Gly 
        115                 120                 125             


Arg Glu Gln Val Ser Leu Val Asp Pro Glu Tyr Leu Pro Arg Arg His 
    130                 135                 140                 


Val Lys Leu Asp Pro Pro Ser Asp Leu Gln Ser Asn Ile Ser Ser Gly 
145                 150                 155                 160 


His Cys Ile Leu Thr Trp Ser Ile Ser Pro Ala Leu Glu Pro Met Thr 
                165                 170                 175     


Thr Leu Leu Ser Tyr Glu Leu Ala Phe Lys Lys Gln Glu Glu Ala Trp 
            180                 185                 190         


Glu Gln Ala Gln His Arg Asp His Ile Val Gly Val Thr Trp Leu Ile 
        195                 200                 205             


Leu Glu Ala Phe Glu Leu Asp Pro Gly Phe Ile His Glu Ala Arg Leu 
    210                 215                 220                 


Arg Val Gln Met Ala Thr Leu Glu Asp Asp Val Val Glu Glu Glu Arg 
225                 230                 235                 240 


Tyr Thr Gly Gln Trp Ser Glu Trp Ser Gln Pro Val Cys Phe Gln Ala 
                245                 250                 255     


Pro Gln Arg Gln Gly Pro Leu Ile Pro Pro Trp Gly Trp Pro Gly Asn 
            260                 265                 270         


Thr Leu Val Ala Val Ser Ile Phe Leu Leu Leu Thr Gly Pro Thr Tyr 
        275                 280                 285             


Leu Leu Phe Lys Leu Ser Pro Arg Val Lys Arg Ile Phe Tyr Gln Asn 
    290                 295                 300                 


Val Pro Ser Pro Ala Met Phe Phe Gln Pro Leu Tyr Ser Val His Asn 
305                 310                 315                 320 


Gly Asn Phe Gln Thr Trp Met Gly Ala His Gly Ala Gly Val Leu Leu 
                325                 330                 335     


Ser Gln Asp Cys Ala Gly Thr Pro Gln Gly Ala Leu Glu Pro Cys Val 
            340                 345                 350         


Gln Glu Ala Thr Ala Leu Leu Thr Cys Gly Pro Ala Arg Pro Trp Lys 
        355                 360                 365             


Ser Val Ala Leu Glu Glu Glu Gln Glu Gly Pro Gly Thr Arg Leu Pro 
    370                 375                 380                 


Gly Asn Leu Ser Ser Glu Asp Val Leu Pro Ala Gly Cys Thr Glu Trp 
385                 390                 395                 400 


Arg Val Gln Thr Leu Ala Tyr Leu Pro Gln Glu Asp Trp Ala Pro Thr 
                405                 410                 415     


Ser Leu Thr Arg Pro Ala Pro Pro Asp Ser Glu Gly Ser Arg Ser Ser 
            420                 425                 430         


Ser Ser Ser Ser Ser Ser Asn Asn Asn Asn Tyr Cys Ala Leu Gly Cys 
        435                 440                 445             


Tyr Gly Gly Trp His Leu Ser Ala Leu Pro Gly Asn Thr Gln Ser Ser 
    450                 455                 460                 


Gly Pro Ile Pro Ala Leu Ala Cys Gly Leu Ser Cys Asp His Gln Gly 
465                 470                 475                 480 


Leu Glu Thr Gln Gln Gly Val Ala Trp Val Leu Ala Gly His Cys Gln 
                485                 490                 495     


Arg Pro Gly Leu His Glu Asp Leu Gln Gly Met Leu Leu Pro Ser Val 
            500                 505                 510         


Leu Ser Lys Ala Arg Ser Trp Thr Phe 
        515                 520     


<210>  310
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Glu Trp Pro Ala Arg Leu Cys Gly Leu Trp Ala Leu Leu Leu Cys 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Gly Gly Gly Ala Ala Pro Thr Glu Thr Gln 
            20                  25                  30          


Pro Pro Val Thr Asn Leu Ser Val Ser Val Glu Asn Leu Cys Thr Val 
        35                  40                  45              


Ile Trp Thr Trp Asn Pro Pro Glu Gly Ala Ser Ser Asn Cys Ser Leu 
    50                  55                  60                  


Trp Tyr Phe Ser His Phe Gly Asp Lys Gln Asp Lys Lys Ile Ala Pro 
65                  70                  75                  80  


Glu Thr Arg Arg Ser Ile Glu Val Pro Leu Asn Glu Arg Ile Cys Leu 
                85                  90                  95      


Gln Val Gly Ser Gln Cys Ser Thr Asn Glu Ser Glu Lys Pro Ser Ile 
            100                 105                 110         


Leu Val Glu Lys Cys Ile Ser Pro Pro Glu Gly Asp Pro Glu Ser Ala 
        115                 120                 125             


Val Thr Glu Leu Gln Cys Ile Trp His Asn Leu Ser Tyr Met Lys Cys 
    130                 135                 140                 


Ser Trp Leu Pro Gly Arg Asn Thr Ser Pro Asp Thr Asn Tyr Thr Leu 
145                 150                 155                 160 


Tyr Tyr Trp His Arg Ser Leu Glu Lys Ile His Gln Cys Glu Asn Ile 
                165                 170                 175     


Phe Arg Glu Gly Gln Tyr Phe Gly Cys Ser Phe Asp Leu Thr Lys Val 
            180                 185                 190         


Lys Asp Ser Ser Phe Glu Gln His Ser Val Gln Ile Met Val Lys Asp 
        195                 200                 205             


Asn Ala Gly Lys Ile Lys Pro Ser Phe Asn Ile Val Pro Leu Thr Ser 
    210                 215                 220                 


Arg Val Lys Pro Asp Pro Pro His Ile Lys Asn Leu Ser Phe His Asn 
225                 230                 235                 240 


Asp Asp Leu Tyr Val Gln Trp Glu Asn Pro Gln Asn Phe Ile Ser Arg 
                245                 250                 255     


Cys Leu Phe Tyr Glu Val Glu Val Asn Asn Ser Gln Thr Glu Thr His 
            260                 265                 270         


Asn Val Phe Tyr Val Gln Glu Ala Lys Cys Glu Asn Pro Glu Phe Glu 
        275                 280                 285             


Arg Asn Val Glu Asn Thr Ser Cys Phe Met Val Pro Gly Val Leu Pro 
    290                 295                 300                 


Asp Thr Leu Asn Thr Val Arg Ile Arg Val Lys Thr Asn Lys Leu Cys 
305                 310                 315                 320 


Tyr Glu Asp Asp Lys Leu Trp Ser Asn Trp Ser Gln Glu Met Ser Ile 
                325                 330                 335     


Gly Lys Lys Arg Asn Ser Thr Leu Tyr Ile Thr Met Leu Leu Ile Val 
            340                 345                 350         


Pro Val Ile Val Ala Gly Ala Ile Ile Val Leu Leu Leu Tyr Leu Lys 
        355                 360                 365             


Arg Leu Lys Ile Ile Ile Phe Pro Pro Ile Pro Asp Pro Gly Lys Ile 
    370                 375                 380                 


Phe Lys Glu Met Phe Gly Asp Gln Asn Asp Asp Thr Leu His Trp Lys 
385                 390                 395                 400 


Lys Tyr Asp Ile Tyr Glu Lys Gln Thr Lys Glu Glu Thr Asp Ser Val 
                405                 410                 415     


Val Leu Ile Glu Asn Leu Lys Lys Ala Ser Gln 
            420                 425         


<210>  311
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Ser Val Glu His Ala Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr 
1               5                   10                  15      


Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly 
            20                  25                  30          


Thr Ser Ser Leu Thr Glu Cys Val Leu Asn Lys Ala Thr Asn Val Ala 
        35                  40                  45              


His Trp Thr Thr Pro Ser Leu Lys Cys Ile Arg Asp Pro Ala Leu Val 
    50                  55                  60                  


His Gln Arg Pro Ala Pro Pro Ser Thr Val Thr Thr Ala Gly Val Thr 
65                  70                  75                  80  


Pro Gln Pro Glu Ser Leu Ser Pro Ser Gly Lys Glu Pro Ala Ala Ser 
                85                  90                  95      


Ser Pro Ser Ser Asn Asn Thr Ala Ala Thr Thr Ala Ala Ile Val Pro 
            100                 105                 110         


Gly Ser Gln Leu Met Pro Ser Lys Ser Pro Ser Thr Gly Thr Thr Glu 
        115                 120                 125             


Ile Ser Ser His Glu Ser Ser His Gly Thr Pro Ser Gln Thr Thr Ala 
    130                 135                 140                 


Lys Asn Trp Glu Leu Thr Ala Ser Ala Ser His Gln Pro Pro Gly Val 
145                 150                 155                 160 


Tyr Pro Gln Gly His Ser Asp Thr Thr Val Ala Ile Ser Thr Ser Thr 
                165                 170                 175     


Val Leu Leu Cys Gly Leu Ser Ala Val Ser Leu Leu Ala Cys Tyr Leu 
            180                 185                 190         


Lys Ser Arg Gln Thr Pro Pro Leu Ala Ser Val Glu Met Glu Ala Met 
        195                 200                 205             


Glu Ala Leu Pro Val Thr Trp Gly Thr Ser Ser Arg Asp Glu Asp Leu 
    210                 215                 220                 


Glu Asn Cys Ser His His Leu 
225                 230     


<210>  312
<211>  538
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Pro Arg Gly Trp Ala Ala Pro Leu Leu Leu Leu Leu Leu Gln Gly 
1               5                   10                  15      


Gly Trp Gly Cys Pro Asp Leu Val Cys Tyr Thr Asp Tyr Leu Gln Thr 
            20                  25                  30          


Val Ile Cys Ile Leu Glu Met Trp Asn Leu His Pro Ser Thr Leu Thr 
        35                  40                  45              


Leu Thr Trp Gln Asp Gln Tyr Glu Glu Leu Lys Asp Glu Ala Thr Ser 
    50                  55                  60                  


Cys Ser Leu His Arg Ser Ala His Asn Ala Thr His Ala Thr Tyr Thr 
65                  70                  75                  80  


Cys His Met Asp Val Phe His Phe Met Ala Asp Asp Ile Phe Ser Val 
                85                  90                  95      


Asn Ile Thr Asp Gln Ser Gly Asn Tyr Ser Gln Glu Cys Gly Ser Phe 
            100                 105                 110         


Leu Leu Ala Glu Ser Ile Lys Pro Ala Pro Pro Phe Asn Val Thr Val 
        115                 120                 125             


Thr Phe Ser Gly Gln Tyr Asn Ile Ser Trp Arg Ser Asp Tyr Glu Asp 
    130                 135                 140                 


Pro Ala Phe Tyr Met Leu Lys Gly Lys Leu Gln Tyr Glu Leu Gln Tyr 
145                 150                 155                 160 


Arg Asn Arg Gly Asp Pro Trp Ala Val Ser Pro Arg Arg Lys Leu Ile 
                165                 170                 175     


Ser Val Asp Ser Arg Ser Val Ser Leu Leu Pro Leu Glu Phe Arg Lys 
            180                 185                 190         


Asp Ser Ser Tyr Glu Leu Gln Val Arg Ala Gly Pro Met Pro Gly Ser 
        195                 200                 205             


Ser Tyr Gln Gly Thr Trp Ser Glu Trp Ser Asp Pro Val Ile Phe Gln 
    210                 215                 220                 


Thr Gln Ser Glu Glu Leu Lys Glu Gly Trp Asn Pro His Leu Leu Leu 
225                 230                 235                 240 


Leu Leu Leu Leu Val Ile Val Phe Ile Pro Ala Phe Trp Ser Leu Lys 
                245                 250                 255     


Thr His Pro Leu Trp Arg Leu Trp Lys Lys Ile Trp Ala Val Pro Ser 
            260                 265                 270         


Pro Glu Arg Phe Phe Met Pro Leu Tyr Lys Gly Cys Ser Gly Asp Phe 
        275                 280                 285             


Lys Lys Trp Val Gly Ala Pro Phe Thr Gly Ser Ser Leu Glu Leu Gly 
    290                 295                 300                 


Pro Trp Ser Pro Glu Val Pro Ser Thr Leu Glu Val Tyr Ser Cys His 
305                 310                 315                 320 


Pro Pro Arg Ser Pro Ala Lys Arg Leu Gln Leu Thr Glu Leu Gln Glu 
                325                 330                 335     


Pro Ala Glu Leu Val Glu Ser Asp Gly Val Pro Lys Pro Ser Phe Trp 
            340                 345                 350         


Pro Thr Ala Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp 
        355                 360                 365             


Arg Pro Tyr Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala 
    370                 375                 380                 


Glu Gly Pro Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro 
385                 390                 395                 400 


Ala Leu Asp Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp 
                405                 410                 415     


Pro Leu Leu Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser 
            420                 425                 430         


Ala Gly Ser Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg 
        435                 440                 445             


Leu Lys Pro Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro 
    450                 455                 460                 


Trp Gly Gly Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser 
465                 470                 475                 480 


Pro Leu Ala Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly 
                485                 490                 495     


Ser Asp Cys Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp 
            500                 505                 510         


Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro 
        515                 520                 525             


Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
    530                 535             


<210>  313
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Val Tyr Tyr Leu Lys Pro Ser Ser Pro Lys His Val Arg Phe Ser 
1               5                   10                  15      


Trp His Gln Asp Ala Val Thr Val Thr Cys Ser Asp Leu Ser Tyr Gly 
            20                  25                  30          


Asp Leu Leu Tyr Glu Val Gln Tyr Arg Ser Pro Phe Asp Thr Glu Trp 
        35                  40                  45              


Gln Ser Lys Gln Glu Asn Thr Cys Asn Val Thr Ile Glu Gly Leu Asp 
    50                  55                  60                  


Ala Glu Lys Cys Tyr Ser Phe Trp Val Arg Val Lys Ala Met Glu Asp 
65                  70                  75                  80  


Val Tyr Gly Pro Asp Thr Tyr Pro Ser Asp Trp Ser Glu Val Thr Cys 
                85                  90                  95      


Trp Gln Arg Gly Glu Ile Arg Asp Ala Cys Ala Glu Thr Pro Thr Pro 
            100                 105                 110         


Pro Lys Pro Lys Leu Ser Lys Phe Ile Leu Ile Ser Ser Leu Ala Ile 
        115                 120                 125             


Leu Leu Met Val Ser Leu Leu Leu Leu Ser Leu Trp Lys Leu Trp Arg 
    130                 135                 140                 


Val Lys Lys Phe Leu Ile Pro Ser Val Pro Asp Pro Lys Ser Ile Phe 
145                 150                 155                 160 


Pro Gly Leu Phe Glu Ile His Gln Gly Asn Phe Gln Glu Trp Ile Thr 
                165                 170                 175     


Asp Thr Gln Asn Val Ala His Leu His Lys Met Ala Gly Ala Glu Gln 
            180                 185                 190         


Glu Ser Gly Pro Glu Glu Pro Leu Val Val Gln Leu Ala Lys Thr Glu 
        195                 200                 205             


Ala Glu Ser Pro Arg Met Leu Asp Pro Gln Thr Glu Glu Lys Glu Ala 
    210                 215                 220                 


Ser Gly Gly Ser Leu Gln Leu Pro His Gln Pro Leu Gln Gly Gly Asp 
225                 230                 235                 240 


Val Val Thr Ile Gly Gly Phe Thr Phe Val Met Asn Asp Arg Ser Tyr 
                245                 250                 255     


Val Ala Leu 
            


<210>  314
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  314

Met Val Leu Leu Trp Leu Thr Leu Leu Leu Ile Ala Leu Pro Cys Leu 
1               5                   10                  15      


Leu Gln Thr Lys Glu Gly Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            20                  25                  30          


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        35                  40                  45              


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    50                  55                  60                  


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
65                  70                  75                  80  


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                85                  90                  95      


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            100                 105                 110         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        115                 120                 125             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    130                 135                 140                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
145                 150                 155                 160 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                165                 170                 175     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            180                 185                 190         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        195                 200                 205             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    210                 215                 220                 


Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu 
225                 230                 235                 240 


Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu 
                245                 250                 255     


Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln 
            260                 265                 270         


Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu 
        275                 280                 285             


Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    290                 295                 300 


<210>  315
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Ile Ile Val Ala His Val Leu Leu Ile Leu Leu Gly Ala Thr Glu 
1               5                   10                  15      


Ile Leu Gln Ala Asp Leu Leu Pro Asp Glu Lys Ile Ser Leu Leu Pro 
            20                  25                  30          


Pro Val Asn Phe Thr Ile Lys Val Thr Gly Leu Ala Gln Val Leu Leu 
        35                  40                  45              


Gln Trp Lys Pro Asn Pro Asp Gln Glu Gln Arg Asn Val Asn Leu Glu 
    50                  55                  60                  


Tyr Gln Val Lys Ile Asn Ala Pro Lys Glu Asp Asp Tyr Glu Thr Arg 
65                  70                  75                  80  


Ile Thr Glu Ser Lys Cys Val Thr Ile Leu His Lys Gly Phe Ser Ala 
                85                  90                  95      


Ser Val Arg Thr Ile Leu Gln Asn Asp His Ser Leu Leu Ala Ser Ser 
            100                 105                 110         


Trp Ala Ser Ala Glu Leu His Ala Pro Pro Gly Ser Pro Gly Thr Ser 
        115                 120                 125             


Ile Val Asn Leu Thr Cys Thr Thr Asn Thr Thr Glu Asp Asn Tyr Ser 
    130                 135                 140                 


Arg Leu Arg Ser Tyr Gln Val Ser Leu His Cys Thr Trp Leu Val Gly 
145                 150                 155                 160 


Thr Asp Ala Pro Glu Asp Thr Gln Tyr Phe Leu Tyr Tyr Arg Tyr Gly 
                165                 170                 175     


Ser Trp Thr Glu Glu Cys Gln Glu Tyr Ser Lys Asp Thr Leu Gly Arg 
            180                 185                 190         


Asn Ile Ala Cys Trp Phe Pro Arg Thr Phe Ile Leu Ser Lys Gly Arg 
        195                 200                 205             


Asp Trp Leu Ala Val Leu Val Asn Gly Ser Ser Lys His Ser Ala Ile 
    210                 215                 220                 


Arg Pro Phe Asp Gln Leu Phe Ala Leu His Ala Ile Asp Gln Ile Asn 
225                 230                 235                 240 


Pro Pro Leu Asn Val Thr Ala Glu Ile Glu Gly Thr Arg Leu Ser Ile 
                245                 250                 255     


Gln Trp Glu Lys Pro Val Ser Ala Phe Pro Ile His Cys Phe Asp Tyr 
            260                 265                 270         


Glu Val Lys Ile His Asn Thr Arg Asn Gly Tyr Leu Gln Ile Glu Lys 
        275                 280                 285             


Leu Met Thr Asn Ala Phe Ile Ser Ile Ile Asp Asp Leu Ser Lys Tyr 
    290                 295                 300                 


Asp Val Gln Val Arg Ala Ala Val Ser Ser Met Cys Arg Glu Ala Gly 
305                 310                 315                 320 


Leu Trp Ser Glu Trp Ser Gln Pro Ile Tyr Val Gly Asn Asp Glu His 
                325                 330                 335     


Lys Pro Leu Arg Glu Trp Phe Val Ile Val Ile Met Ala Thr Ile Cys 
            340                 345                 350         


Phe Ile Leu Leu Ile Leu Ser Leu Ile Cys Lys Ile Cys His Leu Trp 
        355                 360                 365             


Ile Lys Leu Phe Pro Pro Ile Pro Ala Pro Lys Ser Asn Ile Lys Asp 
    370                 375                 380                 


Leu Phe Val Thr Thr Asn Tyr Glu Lys Ala Gly Ser Ser Glu Thr Glu 
385                 390                 395                 400 


Ile Glu Val Ile Cys Tyr Ile Glu Lys Pro Gly Val Glu Thr Leu Glu 
                405                 410                 415     


Asp Ser Val Phe 
            420 


<210>  316
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  316

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Lys Ser Asp Leu Arg Thr Val Ala Pro 
            20                  25                  30          


Ala Ser Ser Leu Asn Val Arg Phe Asp Ser Arg Thr Met Asn Leu Ser 
        35                  40                  45              


Trp Asp Cys Gln Glu Asn Thr Thr Phe Ser Lys Cys Phe Leu Thr Asp 
    50                  55                  60                  


Lys Lys Asn Arg Val Val Glu Pro Arg Leu Ser Asn Asn Glu Cys Ser 
65                  70                  75                  80  


Cys Thr Phe Arg Glu Ile Cys Leu His Glu Gly Val Thr Phe Glu Val 
                85                  90                  95      


His Val Asn Thr Ser Gln Arg Gly Phe Gln Gln Lys Leu Leu Tyr Pro 
            100                 105                 110         


Asn Ser Gly Arg Glu Gly Thr Ala Ala Gln Asn Phe Ser Cys Phe Ile 
        115                 120                 125             


Tyr Asn Ala Asp Leu Met Asn Cys Thr Trp Ala Arg Gly Pro Thr Ala 
    130                 135                 140                 


Pro Arg Asp Val Gln Tyr Phe Leu Tyr Ile Arg Asn Ser Lys Arg Arg 
145                 150                 155                 160 


Arg Glu Ile Arg Cys Pro Tyr Tyr Ile Gln Asp Ser Gly Thr His Val 
                165                 170                 175     


Gly Cys His Leu Asp Asn Leu Ser Gly Leu Thr Ser Arg Asn Tyr Phe 
            180                 185                 190         


Leu Val Asn Gly Thr Ser Arg Glu Ile Gly Ile Gln Phe Phe Asp Ser 
        195                 200                 205             


Leu Leu Asp Thr Lys Lys Ile Glu Arg Phe Asn Pro Pro Ser Asn Val 
    210                 215                 220                 


Thr Val Arg Cys Asn Thr Thr His Cys Leu Val Arg Trp Lys Gln Pro 
225                 230                 235                 240 


Arg Thr Tyr Gln Lys Leu Ser Tyr Leu Asp Phe Gln Tyr Gln Leu Asp 
                245                 250                 255     


Val His Arg Lys Asn Thr Gln Pro Gly Thr Glu Asn Leu Leu Ile Asn 
            260                 265                 270         


Val Ser Gly Asp Leu Glu Asn Arg Tyr Asn Phe Pro Ser Ser Glu Pro 
        275                 280                 285             


Arg Ala Lys His Ser Val Lys Ile Arg Ala Ala Asp Val Arg Ile Leu 
    290                 295                 300                 


Asn Trp Ser Ser Trp Ser Glu Ala Ile Glu Phe Gly Ser Asp Asp Gly 
305                 310                 315                 320 


Asn Leu Gly Ser Val Tyr Ile Tyr Val Leu Leu Ile Val Gly Thr Leu 
                325                 330                 335     


Val Cys Gly Ile Val Leu Gly Phe Leu Phe Lys Arg Phe Leu Arg Ile 
            340                 345                 350         


Gln Arg Leu Phe Pro Pro Val Pro Gln Ile Lys Asp Lys Leu Asn Asp 
        355                 360                 365             


Asn His Glu Val Glu Asp Glu Ile Ile Trp Glu Glu Phe Thr Pro Glu 
    370                 375                 380                 


Glu Gly Lys Gly Tyr Arg Glu Glu Val Leu Thr Val Lys Glu Ile Thr 
385                 390                 395                 400 


<210>  317
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Val Leu Ala Gln Gly Leu Leu Ser Met Ala Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Glu Arg Ser Leu Ala Gly Ala Glu Glu Thr Ile Pro Leu Gln Thr 
            20                  25                  30          


Leu Arg Cys Tyr Asn Asp Tyr Thr Ser His Ile Thr Cys Arg Trp Ala 
        35                  40                  45              


Asp Thr Gln Asp Ala Gln Arg Leu Val Asn Val Thr Leu Ile Arg Arg 
    50                  55                  60                  


Val Asn Glu Asp Leu Leu Glu Pro Val Ser Cys Asp Leu Ser Asp Asp 
65                  70                  75                  80  


Met Pro Trp Ser Ala Cys Pro His Pro Arg Cys Val Pro Arg Arg Cys 
                85                  90                  95      


Val Ile Pro Cys Gln Ser Phe Val Val Thr Asp Val Asp Tyr Phe Ser 
            100                 105                 110         


Phe Gln Pro Asp Arg Pro Leu Gly Thr Arg Leu Thr Val Thr Leu Thr 
        115                 120                 125             


Gln His Val Gln Pro Pro Glu Pro Arg Asp Leu Gln Ile Ser Thr Asp 
    130                 135                 140                 


Gln Asp His Phe Leu Leu Thr Trp Ser Val Ala Leu Gly Ser Pro Gln 
145                 150                 155                 160 


Ser His Trp Leu Ser Pro Gly Asp Leu Glu Phe Glu Val Val Tyr Lys 
                165                 170                 175     


Arg Leu Gln Asp Ser Trp Glu Asp Ala Ala Ile Leu Leu Ser Asn Thr 
            180                 185                 190         


Ser Gln Ala Thr Leu Gly Pro Glu His Leu Met Pro Ser Ser Thr Tyr 
        195                 200                 205             


Val Ala Arg Val Arg Thr Arg Leu Ala Pro Gly Ser Arg Leu Ser Gly 
    210                 215                 220                 


Arg Pro Ser Lys Trp Ser Pro Glu Val Cys Trp Asp Ser Gln Pro Gly 
225                 230                 235                 240 


Asp Glu Ala Gln Pro Gln Asn Leu Glu Cys Phe Phe Asp Gly Ala Ala 
                245                 250                 255     


Val Leu Ser Cys Ser Trp Glu Val Arg Lys Glu Val Ala Ser Ser Val 
            260                 265                 270         


Ser Phe Gly Leu Phe Tyr Lys Pro Ser Pro Asp Ala Gly Glu Glu Glu 
        275                 280                 285             


Cys Ser Pro Val Leu Arg Glu Gly Leu Gly Ser Leu His Thr Arg His 
    290                 295                 300                 


His Cys Gln Ile Pro Val Pro Asp Pro Ala Thr His Gly Gln Tyr Ile 
305                 310                 315                 320 


Val Ser Val Gln Pro Arg Arg Ala Glu Lys His Ile Lys Ser Ser Val 
                325                 330                 335     


Asn Ile Gln Met Ala Pro Pro Ser Leu Asn Val Thr Lys Asp Gly Asp 
            340                 345                 350         


Ser Tyr Ser Leu Arg Trp Glu Thr Met Lys Met Arg Tyr Glu His Ile 
        355                 360                 365             


Asp His Thr Phe Glu Ile Gln Tyr Arg Lys Asp Thr Ala Thr Trp Lys 
    370                 375                 380                 


Asp Ser Lys Thr Glu Thr Leu Gln Asn Ala His Ser Met Ala Leu Pro 
385                 390                 395                 400 


Ala Leu Glu Pro Ser Thr Arg Tyr Trp Ala Arg Val Arg Val Arg Thr 
                405                 410                 415     


Ser Arg Thr Gly Tyr Asn Gly Ile Trp Ser Glu Trp Ser Glu Ala Arg 
            420                 425                 430         


Ser Trp Asp Thr Glu Ser Val Leu Pro Met Trp Val Leu Ala Leu Ile 
        435                 440                 445             


Val Ile Phe Leu Thr Ile Ala Val Leu Leu Ala Leu Arg Phe Cys Gly 
    450                 455                 460                 


Ile Tyr Gly Tyr Arg Leu Arg Arg Lys Trp Glu Glu Lys Ile Pro Asn 
465                 470                 475                 480 


Pro Ser Lys Ser His Leu Phe Gln Asn Gly Ser Ala Glu Leu Trp Pro 
                485                 490                 495     


Pro Gly Ser Met Ser Ala Phe Thr Ser Gly Ser Pro Pro His Gln Gly 
            500                 505                 510         


Pro Trp Gly Ser Arg Phe Pro Glu Leu Glu Gly Val Phe Pro Val Gly 
        515                 520                 525             


Phe Gly Asp Ser Glu Val Ser Pro Leu Thr Ile Glu Asp Pro Lys His 
    530                 535                 540                 


Val Cys Asp Pro Pro Ser Gly Pro Asp Thr Thr Pro Ala Ala Ser Asp 
545                 550                 555                 560 


Leu Pro Thr Glu Gln Pro Pro Ser Pro Gln Pro Gly Pro Pro Ala Ala 
                565                 570                 575     


Ser His Thr Pro Glu Lys Gln Ala Ser Ser Phe Asp Phe Asn Gly Pro 
            580                 585                 590         


Tyr Leu Gly Pro Pro His Ser Arg Ser Leu Pro Asp Ile Leu Gly Gln 
        595                 600                 605             


Pro Glu Pro Pro Gln Glu Gly Gly Ser Gln Lys Ser Pro Pro Pro Gly 
    610                 615                 620                 


Ser Leu Glu Tyr Leu Cys Leu Pro Ala Gly Gly Gln Val Gln Leu Val 
625                 630                 635                 640 


Pro Leu Ala Gln Ala Met Gly Pro Gly Gln Ala Val Glu Val Glu Arg 
                645                 650                 655     


Arg Pro Ser Gln Gly Ala Ala Gly Ser Pro Ser Leu Glu Ser Gly Gly 
            660                 665                 670         


Gly Pro Ala Pro Pro Ala Leu Gly Pro Arg Val Gly Gly Gln Asp Gln 
        675                 680                 685             


Lys Asp Ser Pro Val Ala Ile Pro Met Ser Ser Gly Asp Thr Glu Asp 
    690                 695                 700                 


Pro Gly Val Ala Ser Gly Tyr Val Ser Ser Ala Asp Leu Val Phe Thr 
705                 710                 715                 720 


Pro Asn Ser Gly Ala Ser Ser Val Ser Leu Val Pro Ser Leu Gly Leu 
                725                 730                 735     


Pro Ser Asp Gln Thr Pro Ser Leu Cys Pro Gly Leu Ala Ser Gly Pro 
            740                 745                 750         


Pro Gly Ala Pro Gly Pro Val Lys Ser Gly Phe Glu Gly Tyr Val Glu 
        755                 760                 765             


Leu Pro Pro Ile Glu Gly Arg Ser Pro Arg Ser Pro Arg Asn Asn Pro 
    770                 775                 780                 


Val Pro Pro Glu Ala Lys Ser Pro Val Leu Asn Pro Gly Glu Arg Pro 
785                 790                 795                 800 


Ala Asp Val Ser Pro Thr Ser Pro Gln Pro Glu Gly Leu Leu Val Leu 
                805                 810                 815     


Gln Gln Val Gly Asp Tyr Cys Phe Leu Pro Gly Leu Gly Pro Gly Pro 
            820                 825                 830         


Leu Ser Leu Arg Ser Lys Pro Ser Ser Pro Gly Pro Gly Pro Glu Ile 
        835                 840                 845             


Lys Asn Leu Asp Gln Ala Phe Gln Val Lys Lys Pro Pro Gly Gln Ala 
    850                 855                 860                 


Val Pro Gln Val Pro Val Ile Gln Leu Phe Lys Ala Leu Lys Gln Gln 
865                 870                 875                 880 


Asp Tyr Leu Ser Leu Pro Pro Trp Glu Val Asn Lys Pro Gly Glu Val 
                885                 890                 895     


Cys 
    


<210>  318
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  318

Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                  15      


Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                  25                  30          


Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                  40                  45              


Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                  55                  60                  


Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                  70                  75                  80  


Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                  90                  95      


Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                 105                 110         


Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                 120                 125             


Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                 135                 140                 


Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                 150                 155                 160 


Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                 170                 175     


Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                 185                 190         


Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                 200                 205             


Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                 215                 220                 


Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                 230                 235                 240 


Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                 250                 255     


Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                 265                 270         


Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                 280                 285             


Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                 295                 300                 


Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                 310                 315                 320 


Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                 330                 335     


Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                 345                 350         


Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                 360                 365             


Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                 375                 380                 


Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                 390                 395                 400 


Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                 410                 415     


Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                 425                 430         


Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                 440                 445             


Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                 455                 460                 


Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                 470                 475                 480 


Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                 490                 495     


Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                 505                 510         


Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                 520                 525             


Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                 535                 540                 


Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                 550                 555                 560 


Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                 570                 575     


Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                 585                 590         


Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                 600                 605             


Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                 615                 620                 


Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                 630                 635                 640 


Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                 650                 655     


Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                 665                 670         


Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                 680                 685             


Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                 695                 700                 


Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                 710                 715                 720 


Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                 730                 735     


Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                 745                 750         


Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                 760                 765             


Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                 775                 780                 


Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                 790                 795                 800 


Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                 810                 815     


Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                 825                 830         


Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                 840                 845             


Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                 855                 860                 


Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                 870                 875                 880 


Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Arg Thr Asp Ile Leu 
                885                 890                 895     


<210>  319
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  319

Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             


<210>  320
<211>  857
<212>  PRT
<213>  Homo sapiens

<400>  320

Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Gly Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Leu Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu 
            420                 425                 430         


Ile Thr Val Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser 
        435                 440                 445             


Ile Lys Ala Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val 
    450                 455                 460                 


Arg Thr Lys Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln 
465                 470                 475                 480 


Leu Pro Val Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe 
                485                 490                 495     


Tyr Arg Thr Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser 
            500                 505                 510         


His Thr Glu Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met 
        515                 520                 525             


Val Arg Met Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu 
    530                 535                 540                 


Phe Thr Phe Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile 
545                 550                 555                 560 


Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val 
                565                 570                 575     


Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro 
            580                 585                 590         


Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His 
        595                 600                 605             


Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp 
    610                 615                 620                 


Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys 
625                 630                 635                 640 


Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu 
                645                 650                 655     


Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys 
            660                 665                 670         


Met Ser Ser Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser 
        675                 680                 685             


Ser Gln Asn Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser 
    690                 695                 700                 


Gly Tyr Arg His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu 
705                 710                 715                 720 


Ser Thr Gln Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln 
                725                 730                 735     


Leu Val Asp His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln 
            740                 745                 750         


Tyr Phe Lys Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser 
        755                 760                 765             


His Phe Glu Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe 
    770                 775                 780                 


Val Arg Leu Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly 
785                 790                 795                 800 


Ser Gly Gln Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe 
                805                 810                 815     


Gly Pro Gly Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met 
            820                 825                 830         


Glu Ala Ala Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr 
        835                 840                 845             


Val Arg Gln Gly Gly Tyr Met Pro Gln 
    850                 855         


<210>  321
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  321

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  322
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Arg Gly Gly Arg Gly Ala Pro Phe Trp Leu Trp Pro Leu Pro Lys 
1               5                   10                  15      


Leu Ala Leu Leu Pro Leu Leu Trp Val Leu Phe Gln Arg Thr Arg Pro 
            20                  25                  30          


Gln Gly Ser Ala Gly Pro Leu Gln Cys Tyr Gly Val Gly Pro Leu Gly 
        35                  40                  45              


Asp Leu Asn Cys Ser Trp Glu Pro Leu Gly Asp Leu Gly Ala Pro Ser 
    50                  55                  60                  


Glu Leu His Leu Gln Ser Gln Lys Tyr Arg Ser Asn Lys Thr Gln Thr 
65                  70                  75                  80  


Val Ala Val Ala Ala Gly Arg Ser Trp Val Ala Ile Pro Arg Glu Gln 
                85                  90                  95      


Leu Thr Met Ser Asp Lys Leu Leu Val Trp Gly Thr Lys Ala Gly Gln 
            100                 105                 110         


Pro Leu Trp Pro Pro Val Phe Val Asn Leu Glu Thr Gln Met Lys Pro 
        115                 120                 125             


Asn Ala Pro Arg Leu Gly Pro Asp Val Asp Phe Ser Glu Asp Asp Pro 
    130                 135                 140                 


Leu Glu Ala Thr Val His Trp Ala Pro Pro Thr Trp Pro Ser His Lys 
145                 150                 155                 160 


Val Leu Ile Cys Gln Phe His Tyr Arg Arg Cys Gln Glu Ala Ala Trp 
                165                 170                 175     


Thr Leu Leu Glu Pro Glu Leu Lys Thr Ile Pro Leu Thr Pro Val Glu 
            180                 185                 190         


Ile Gln Asp Leu Glu Leu Ala Thr Gly Tyr Lys Val Tyr Gly Arg Cys 
        195                 200                 205             


Arg Met Glu Lys Glu Glu Asp Leu Trp Gly Glu Trp Ser Pro Ile Leu 
    210                 215                 220                 


Ser Phe Gln Thr Pro Pro Ser Ala Pro Lys Asp Val Trp Val Ser Gly 
225                 230                 235                 240 


Asn Leu Cys Gly Thr Pro Gly Gly Glu Glu Pro Leu Leu Leu Trp Lys 
                245                 250                 255     


Ala Pro Gly Pro Cys Val Gln Val Ser Tyr Lys Val Trp Phe Trp Val 
            260                 265                 270         


Gly Gly Arg Glu Leu Ser Pro Glu Gly Ile Thr Cys Cys Cys Ser Leu 
        275                 280                 285             


Ile Pro Ser Gly Ala Glu Trp Ala Arg Val Ser Ala Val Asn Ala Thr 
    290                 295                 300                 


Ser Trp Glu Pro Leu Thr Asn Leu Ser Leu Val Cys Leu Asp Ser Ala 
305                 310                 315                 320 


Ser Ala Pro Arg Ser Val Ala Val Ser Ser Ile Ala Gly Ser Thr Glu 
                325                 330                 335     


Leu Leu Val Thr Trp Gln Pro Gly Pro Gly Glu Pro Leu Glu His Val 
            340                 345                 350         


Val Asp Trp Ala Arg Asp Gly Asp Pro Leu Glu Lys Leu Asn Trp Val 
        355                 360                 365             


Arg Leu Pro Pro Gly Asn Leu Ser Ala Leu Leu Pro Gly Asn Phe Thr 
    370                 375                 380                 


Val Gly Val Pro Tyr Arg Ile Thr Val Thr Ala Val Ser Ala Ser Gly 
385                 390                 395                 400 


Leu Ala Ser Ala Ser Ser Val Trp Gly Phe Arg Glu Glu Leu Ala Pro 
                405                 410                 415     


Leu Val Gly Pro Thr Leu Trp Arg Leu Gln Asp Ala Pro Pro Gly Thr 
            420                 425                 430         


Pro Ala Ile Ala Trp Gly Glu Val Pro Arg His Gln Leu Arg Gly His 
        435                 440                 445             


Leu Thr His Tyr Thr Leu Cys Ala Gln Ser Gly Thr Ser Pro Ser Val 
    450                 455                 460                 


Cys Met Asn Val Ser Gly Asn Thr Gln Ser Val Thr Leu Pro Asp Leu 
465                 470                 475                 480 


Pro Trp Gly Pro Cys Glu Leu Trp Val Thr Ala Ser Thr Ile Ala Gly 
                485                 490                 495     


Gln Gly Pro Pro Gly Pro Ile Leu Arg Leu His Leu Pro Asp Asn Thr 
            500                 505                 510         


Leu Arg Trp Lys Val Leu Pro Gly Ile Leu Phe Leu Trp Gly Leu Phe 
        515                 520                 525             


Leu Leu Gly Cys Gly Leu Ser Leu Ala Thr Ser Gly Arg Cys Tyr His 
    530                 535                 540                 


Leu Arg His Lys Val Leu Pro Arg Trp Val Trp Glu Lys Val Pro Asp 
545                 550                 555                 560 


Pro Ala Asn Ser Ser Ser Gly Gln Pro His Met Glu Gln Val Pro Glu 
                565                 570                 575     


Ala Gln Pro Leu Gly Asp Leu Pro Ile Leu Glu Val Glu Glu Met Glu 
            580                 585                 590         


Pro Pro Pro Val Met Glu Ser Ser Gln Pro Ala Gln Ala Thr Ala Pro 
        595                 600                 605             


Leu Asp Ser Gly Tyr Glu Lys His Phe Leu Pro Thr Pro Glu Glu Leu 
    610                 615                 620                 


Gly Leu Leu Gly Pro Pro Arg Pro Gln Val Leu Ala 
625                 630                 635     


<210>  323
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Lys Leu Ser Pro Gln Pro Ser Cys Val Asn Leu Gly Met Met Trp 
1               5                   10                  15      


Thr Trp Ala Leu Trp Met Leu Pro Ser Leu Cys Lys Phe Ser Leu Ala 
            20                  25                  30          


Ala Leu Pro Ala Lys Pro Glu Asn Ile Ser Cys Val Tyr Tyr Tyr Arg 
        35                  40                  45              


Lys Asn Leu Thr Cys Thr Trp Ser Pro Gly Lys Glu Thr Ser Tyr Thr 
    50                  55                  60                  


Gln Tyr Thr Val Lys Arg Thr Tyr Ala Phe Gly Glu Lys His Asp Asn 
65                  70                  75                  80  


Cys Thr Thr Asn Ser Ser Thr Ser Glu Asn Arg Ala Ser Cys Ser Phe 
                85                  90                  95      


Phe Leu Pro Arg Ile Thr Ile Pro Asp Asn Tyr Thr Ile Glu Val Glu 
            100                 105                 110         


Ala Glu Asn Gly Asp Gly Val Ile Lys Ser His Met Thr Tyr Trp Arg 
        115                 120                 125             


Leu Glu Asn Ile Ala Lys Thr Glu Pro Pro Lys Ile Phe Arg Val Lys 
    130                 135                 140                 


Pro Val Leu Gly Ile Lys Arg Met Ile Gln Ile Glu Trp Ile Lys Pro 
145                 150                 155                 160 


Glu Leu Ala Pro Val Ser Ser Asp Leu Lys Tyr Thr Leu Arg Phe Arg 
                165                 170                 175     


Thr Val Asn Ser Thr Ser Trp Met Glu Val Asn Phe Ala Lys Asn Arg 
            180                 185                 190         


Lys Asp Lys Asn Gln Thr Tyr Asn Leu Thr Gly Leu Gln Pro Phe Thr 
        195                 200                 205             


Glu Tyr Val Ile Ala Leu Arg Cys Ala Val Lys Glu Ser Lys Phe Trp 
    210                 215                 220                 


Ser Asp Trp Ser Gln Glu Lys Met Gly Met Thr Glu Glu Glu Ala Pro 
225                 230                 235                 240 


Cys Gly Leu Glu Leu Trp Arg Val Leu Lys Pro Ala Glu Ala Asp Gly 
                245                 250                 255     


Arg Arg Pro Val Arg Leu Leu Trp Lys Lys Ala Arg Gly Ala Pro Val 
            260                 265                 270         


Leu Glu Lys Thr Leu Gly Tyr Asn Ile Trp Tyr Tyr Pro Glu Ser Asn 
        275                 280                 285             


Thr Asn Leu Thr Glu Thr Met Asn Thr Thr Asn Gln Gln Leu Glu Leu 
    290                 295                 300                 


His Leu Gly Gly Glu Ser Phe Trp Val Ser Met Ile Ser Tyr Asn Ser 
305                 310                 315                 320 


Leu Gly Lys Ser Pro Val Ala Thr Leu Arg Ile Pro Ala Ile Gln Glu 
                325                 330                 335     


Lys Ser Phe Gln Cys Ile Glu Val Met Gln Ala Cys Val Ala Glu Asp 
            340                 345                 350         


Gln Leu Val Val Lys Trp Gln Ser Ser Ala Leu Asp Val Asn Thr Trp 
        355                 360                 365             


Met Ile Glu Trp Phe Pro Asp Val Asp Ser Glu Pro Thr Thr Leu Ser 
    370                 375                 380                 


Trp Glu Ser Val Ser Gln Ala Thr Asn Trp Thr Ile Gln Gln Asp Lys 
385                 390                 395                 400 


Leu Lys Pro Phe Trp Cys Tyr Asn Ile Ser Val Tyr Pro Met Leu His 
                405                 410                 415     


Asp Lys Val Gly Glu Pro Tyr Ser Ile Gln Ala Tyr Ala Lys Glu Gly 
            420                 425                 430         


Val Pro Ser Glu Gly Pro Glu Thr Lys Val Glu Asn Ile Gly Val Lys 
        435                 440                 445             


Thr Val Thr Ile Thr Trp Lys Glu Ile Pro Lys Ser Glu Arg Lys Gly 
    450                 455                 460                 


Ile Ile Cys Asn Tyr Thr Ile Phe Tyr Gln Ala Glu Gly Gly Lys Gly 
465                 470                 475                 480 


Phe Ser Lys Thr Val Asn Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser 
                485                 490                 495     


Leu Lys Arg Lys Thr Ser Tyr Ile Val Gln Val Met Ala Ser Thr Ser 
            500                 505                 510         


Ala Gly Gly Thr Asn Gly Thr Ser Ile Asn Phe Lys Thr Leu Ser Phe 
        515                 520                 525             


Ser Val Phe Glu Ile Ile Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu 
    530                 535                 540                 


Leu Ile Leu Ile Ile Leu Thr Val Ala Tyr Gly Leu Lys Lys Pro Asn 
545                 550                 555                 560 


Lys Leu Thr His Leu Cys Trp Pro Thr Val Pro Asn Pro Ala Glu Ser 
                565                 570                 575     


Ser Ile Ala Thr Trp His Gly Asp Asp Phe Lys Asp Lys Leu Asn Leu 
            580                 585                 590         


Lys Glu Ser Asp Asp Ser Val Asn Thr Glu Asp Arg Ile Leu Lys Pro 
        595                 600                 605             


Cys Ser Thr Pro Ser Asp Lys Leu Val Ile Asp Lys Leu Val Val Asn 
    610                 615                 620                 


Phe Gly Asn Val Leu Gln Glu Ile Phe Thr Asp Glu Ala Arg Thr Gly 
625                 630                 635                 640 


Gln Glu Asn Asn Leu Gly Gly Glu Lys Asn Gly Tyr Val Thr Cys Pro 
                645                 650                 655     


Phe Arg Pro Asp Cys Pro Leu Gly Lys Ser Phe Glu Glu Leu Pro Val 
            660                 665                 670         


Ser Pro Glu Ile Pro Pro Arg Lys Ser Gln Tyr Leu Arg Ser Arg Met 
        675                 680                 685             


Pro Glu Gly Thr Arg Pro Glu Ala Lys Glu Gln Leu Leu Phe Ser Gly 
    690                 695                 700                 


Gln Ser Leu Val Pro Asp His Leu Cys Glu Glu Gly Ala Pro Asn Pro 
705                 710                 715                 720 


Tyr Leu Lys Asn Ser Val Thr Ala Arg Glu Phe Leu Val Ser Glu Lys 
                725                 730                 735     


Leu Pro Glu His Thr Lys Gly Glu Val 
            740                 745 


<210>  324
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  324

Met Ala Ala Pro Val Pro Trp Ala Cys Cys Ala Val Leu Ala Ala Ala 
1               5                   10                  15      


Ala Ala Val Val Tyr Ala Gln Arg His Ser Pro Gln Glu Ala Pro His 
            20                  25                  30          


Val Gln Tyr Glu Arg Leu Gly Ser Asp Val Thr Leu Pro Cys Gly Thr 
        35                  40                  45              


Ala Asn Trp Asp Ala Ala Val Thr Trp Arg Val Asn Gly Thr Asp Leu 
    50                  55                  60                  


Ala Pro Asp Leu Leu Asn Gly Ser Gln Leu Val Leu His Gly Leu Glu 
65                  70                  75                  80  


Leu Gly His Ser Gly Leu Tyr Ala Cys Phe His Arg Asp Ser Trp His 
                85                  90                  95      


Leu Arg His Gln Val Leu Leu His Val Gly Leu Pro Pro Arg Glu Pro 
            100                 105                 110         


Val Leu Ser Cys Arg Ser Asn Thr Tyr Pro Lys Gly Phe Tyr Cys Ser 
        115                 120                 125             


Trp His Leu Pro Thr Pro Thr Tyr Ile Pro Asn Thr Phe Asn Val Thr 
    130                 135                 140                 


Val Leu His Gly Ser Lys Ile Met Val Cys Glu Lys Asp Pro Ala Leu 
145                 150                 155                 160 


Lys Asn Arg Cys His Ile Arg Tyr Met His Leu Phe Ser Thr Ile Lys 
                165                 170                 175     


Tyr Lys Val Ser Ile Ser Val Ser Asn Ala Leu Gly His Asn Ala Thr 
            180                 185                 190         


Ala Ile Thr Phe Asp Glu Phe Thr Ile Val Lys Pro Asp Pro Pro Glu 
        195                 200                 205             


Asn Val Val Ala Arg Pro Val Pro Ser Asn Pro Arg Arg Leu Glu Val 
    210                 215                 220                 


Thr Trp Gln Thr Pro Ser Thr Trp Pro Asp Pro Glu Ser Phe Pro Leu 
225                 230                 235                 240 


Lys Phe Phe Leu Arg Tyr Arg Pro Leu Ile Leu Asp Gln Trp Gln His 
                245                 250                 255     


Val Glu Leu Ser Asp Gly Thr Ala His Thr Ile Thr Asp Ala Tyr Ala 
            260                 265                 270         


Gly Lys Glu Tyr Ile Ile Gln Val Ala Ala Lys Asp Asn Glu Ile Gly 
        275                 280                 285             


Thr Trp Ser Asp Trp Ser Val Ala Ala His Ala Thr Pro Trp Thr Glu 
    290                 295                 300                 


Glu Pro Arg His Leu Thr Thr Glu Ala Gln Ala Ala Glu Thr Thr Thr 
305                 310                 315                 320 


Ser Thr Thr Ser Ser Leu Ala Pro Pro Pro Thr Thr Lys Ile Cys Asp 
                325                 330                 335     


Pro Gly Glu Leu Gly Ser Gly Gly Gly Pro Ser Ala Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ile Thr Leu Ala Leu Ala Ala Ala Ala Ala Thr Ala Ser 
        355                 360                 365             


Ser Leu Leu Ile 
    370         


<210>  325
<211>  1097
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Met Asp Ile Tyr Val Cys Leu Lys Arg Pro Ser Trp Met Val Asp 
1               5                   10                  15      


Asn Lys Arg Met Arg Thr Ala Ser Asn Phe Gln Trp Leu Leu Ser Thr 
            20                  25                  30          


Phe Ile Leu Leu Tyr Leu Met Asn Gln Val Asn Ser Gln Lys Lys Gly 
        35                  40                  45              


Ala Pro His Asp Leu Lys Cys Val Thr Asn Asn Leu Gln Val Trp Asn 
    50                  55                  60                  


Cys Ser Trp Lys Ala Pro Ser Gly Thr Gly Arg Gly Thr Asp Tyr Glu 
65                  70                  75                  80  


Val Cys Ile Glu Asn Arg Ser Arg Ser Cys Tyr Gln Leu Glu Lys Thr 
                85                  90                  95      


Ser Ile Lys Ile Pro Ala Leu Ser His Gly Asp Tyr Glu Ile Thr Ile 
            100                 105                 110         


Asn Ser Leu His Asp Phe Gly Ser Ser Thr Ser Lys Phe Thr Leu Asn 
        115                 120                 125             


Glu Gln Asn Val Ser Leu Ile Pro Asp Thr Pro Glu Ile Leu Asn Leu 
    130                 135                 140                 


Ser Ala Asp Phe Ser Thr Ser Thr Leu Tyr Leu Lys Trp Asn Asp Arg 
145                 150                 155                 160 


Gly Ser Val Phe Pro His Arg Ser Asn Val Ile Trp Glu Ile Lys Val 
                165                 170                 175     


Leu Arg Lys Glu Ser Met Glu Leu Val Lys Leu Val Thr His Asn Thr 
            180                 185                 190         


Thr Leu Asn Gly Lys Asp Thr Leu His His Trp Ser Trp Ala Ser Asp 
        195                 200                 205             


Met Pro Leu Glu Cys Ala Ile His Phe Val Glu Ile Arg Cys Tyr Ile 
    210                 215                 220                 


Asp Asn Leu His Phe Ser Gly Leu Glu Glu Trp Ser Asp Trp Ser Pro 
225                 230                 235                 240 


Val Lys Asn Ile Ser Trp Ile Pro Asp Ser Gln Thr Lys Val Phe Pro 
                245                 250                 255     


Gln Asp Lys Val Ile Leu Val Gly Ser Asp Ile Thr Phe Cys Cys Val 
            260                 265                 270         


Ser Gln Glu Lys Val Leu Ser Ala Leu Ile Gly His Thr Asn Cys Pro 
        275                 280                 285             


Leu Ile His Leu Asp Gly Glu Asn Val Ala Ile Lys Ile Arg Asn Ile 
    290                 295                 300                 


Ser Val Ser Ala Ser Ser Gly Thr Asn Val Val Phe Thr Thr Glu Asp 
305                 310                 315                 320 


Asn Ile Phe Gly Thr Val Ile Phe Ala Gly Tyr Pro Pro Asp Thr Pro 
                325                 330                 335     


Gln Gln Leu Asn Cys Glu Thr His Asp Leu Lys Glu Ile Ile Cys Ser 
            340                 345                 350         


Trp Asn Pro Gly Arg Val Thr Ala Leu Val Gly Pro Arg Ala Thr Ser 
        355                 360                 365             


Tyr Thr Leu Val Glu Ser Phe Ser Gly Lys Tyr Val Arg Leu Lys Arg 
    370                 375                 380                 


Ala Glu Ala Pro Thr Asn Glu Ser Tyr Gln Leu Leu Phe Gln Met Leu 
385                 390                 395                 400 


Pro Asn Gln Glu Ile Tyr Asn Phe Thr Leu Asn Ala His Asn Pro Leu 
                405                 410                 415     


Gly Arg Ser Gln Ser Thr Ile Leu Val Asn Ile Thr Glu Lys Val Tyr 
            420                 425                 430         


Pro His Thr Pro Thr Ser Phe Lys Val Lys Asp Ile Asn Ser Thr Ala 
        435                 440                 445             


Val Lys Leu Ser Trp His Leu Pro Gly Asn Phe Ala Lys Ile Asn Phe 
    450                 455                 460                 


Leu Cys Glu Ile Glu Ile Lys Lys Ser Asn Ser Val Gln Glu Gln Arg 
465                 470                 475                 480 


Asn Val Thr Ile Lys Gly Val Glu Asn Ser Ser Tyr Leu Val Ala Leu 
                485                 490                 495     


Asp Lys Leu Asn Pro Tyr Thr Leu Tyr Thr Phe Arg Ile Arg Cys Ser 
            500                 505                 510         


Thr Glu Thr Phe Trp Lys Trp Ser Lys Trp Ser Asn Lys Lys Gln His 
        515                 520                 525             


Leu Thr Thr Glu Ala Ser Pro Ser Lys Gly Pro Asp Thr Trp Arg Glu 
    530                 535                 540                 


Trp Ser Ser Asp Gly Lys Asn Leu Ile Ile Tyr Trp Lys Pro Leu Pro 
545                 550                 555                 560 


Ile Asn Glu Ala Asn Gly Lys Ile Leu Ser Tyr Asn Val Ser Cys Ser 
                565                 570                 575     


Ser Asp Glu Glu Thr Gln Ser Leu Ser Glu Ile Pro Asp Pro Gln His 
            580                 585                 590         


Lys Ala Glu Ile Arg Leu Asp Lys Asn Asp Tyr Ile Ile Ser Val Val 
        595                 600                 605             


Ala Lys Asn Ser Val Gly Ser Ser Pro Pro Ser Lys Ile Ala Ser Met 
    610                 615                 620                 


Glu Ile Pro Asn Asp Asp Leu Lys Ile Glu Gln Val Val Gly Met Gly 
625                 630                 635                 640 


Lys Gly Ile Leu Leu Thr Trp His Tyr Asp Pro Asn Met Thr Cys Asp 
                645                 650                 655     


Tyr Val Ile Lys Trp Cys Asn Ser Ser Arg Ser Glu Pro Cys Leu Met 
            660                 665                 670         


Asp Trp Arg Lys Val Pro Ser Asn Ser Thr Glu Thr Val Ile Glu Ser 
        675                 680                 685             


Asp Glu Phe Arg Pro Gly Ile Arg Tyr Asn Phe Phe Leu Tyr Gly Cys 
    690                 695                 700                 


Arg Asn Gln Gly Tyr Gln Leu Leu Arg Ser Met Ile Gly Tyr Ile Glu 
705                 710                 715                 720 


Glu Leu Ala Pro Ile Val Ala Pro Asn Phe Thr Val Glu Asp Thr Ser 
                725                 730                 735     


Ala Asp Ser Ile Leu Val Lys Trp Glu Asp Ile Pro Val Glu Glu Leu 
            740                 745                 750         


Arg Gly Phe Leu Arg Gly Tyr Leu Phe Tyr Phe Gly Lys Gly Glu Arg 
        755                 760                 765             


Asp Thr Ser Lys Met Arg Val Leu Glu Ser Gly Arg Ser Asp Ile Lys 
    770                 775                 780                 


Val Lys Asn Ile Thr Asp Ile Ser Gln Lys Thr Leu Arg Ile Ala Asp 
785                 790                 795                 800 


Leu Gln Gly Lys Thr Ser Tyr His Leu Val Leu Arg Ala Tyr Thr Asp 
                805                 810                 815     


Gly Gly Val Gly Pro Glu Lys Ser Met Tyr Val Val Thr Lys Glu Asn 
            820                 825                 830         


Ser Val Gly Leu Ile Ile Ala Ile Leu Ile Pro Val Ala Val Ala Val 
        835                 840                 845             


Ile Val Gly Val Val Thr Ser Ile Leu Cys Tyr Arg Lys Arg Glu Trp 
    850                 855                 860                 


Ile Lys Glu Thr Phe Tyr Pro Asp Ile Pro Asn Pro Glu Asn Cys Lys 
865                 870                 875                 880 


Ala Leu Gln Phe Gln Lys Ser Val Cys Glu Gly Ser Ser Ala Leu Lys 
                885                 890                 895     


Thr Leu Glu Met Asn Pro Cys Thr Pro Asn Asn Val Glu Val Leu Glu 
            900                 905                 910         


Thr Arg Ser Ala Phe Pro Lys Ile Glu Asp Thr Glu Ile Ile Ser Pro 
        915                 920                 925             


Val Ala Glu Arg Pro Glu Asp Arg Ser Asp Ala Glu Pro Glu Asn His 
    930                 935                 940                 


Val Val Val Ser Tyr Cys Pro Pro Ile Ile Glu Glu Glu Ile Pro Asn 
945                 950                 955                 960 


Pro Ala Ala Asp Glu Ala Gly Gly Thr Ala Gln Val Ile Tyr Ile Asp 
                965                 970                 975     


Val Gln Ser Met Tyr Gln Pro Gln Ala Lys Pro Glu Glu Glu Gln Glu 
            980                 985                 990         


Asn Asp Pro Val Gly Gly Ala Gly  Tyr Lys Pro Gln Met  His Leu Pro 
        995                 1000                 1005             


Ile Asn  Ser Thr Val Glu Asp  Ile Ala Ala Glu Glu  Asp Leu Asp 
    1010                 1015                 1020             


Lys Thr  Ala Gly Tyr Arg Pro  Gln Ala Asn Val Asn  Thr Trp Asn 
    1025                 1030                 1035             


Leu Val  Ser Pro Asp Ser Pro  Arg Ser Ile Asp Ser  Asn Ser Glu 
    1040                 1045                 1050             


Ile Val  Ser Phe Gly Ser Pro  Cys Ser Ile Asn Ser  Arg Gln Phe 
    1055                 1060                 1065             


Leu Ile  Pro Pro Lys Asp Glu  Asp Ser Pro Lys Ser  Asn Gly Gly 
    1070                 1075                 1080             


Gly Trp  Ser Phe Thr Asn Phe  Phe Gln Asn Lys Pro  Asn Asp 
    1085                 1090                 1095         


<210>  326
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  326

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Gly Glu Thr Arg Val Val 
                325                 330                 335     


Thr Ala His Arg Gly His 
            340         


<210>  327
<211>  660
<212>  PRT
<213>  Homo sapiens

<400>  327

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Asp Arg 
            660 


<210>  328
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  328

Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Arg Arg His Ser Cys Pro Trp 
                645                 650                 655     


Thr Gly Ser 
            


<210>  329
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  329

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  330
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Asp His Leu Gly Ala Ser Leu Trp Pro Gln Val Gly Ser Leu Cys 
1               5                   10                  15      


Leu Leu Leu Ala Gly Ala Ala Trp Ala Pro Pro Pro Asn Leu Pro Asp 
            20                  25                  30          


Pro Lys Phe Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu 
        35                  40                  45              


Glu Leu Leu Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp 
    50                  55                  60                  


Glu Glu Ala Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser 
65                  70                  75                  80  


Tyr Gln Leu Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala 
                85                  90                  95      


Pro Thr Ala Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala 
            100                 105                 110         


Asp Thr Ser Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser 
        115                 120                 125             


Gly Ala Pro Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu 
    130                 135                 140                 


Leu Asp Ala Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly 
145                 150                 155                 160 


His Val Val Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser 
                165                 170                 175     


His Ile Arg Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser 
            180                 185                 190         


Val Gln Arg Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser 
        195                 200                 205             


Asn Leu Arg Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met 
    210                 215                 220                 


Ala Glu Pro Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val 
225                 230                 235                 240 


Ser Leu Leu Thr Pro Ser Asp Leu Asp Pro Leu Ile Leu Thr Leu Ser 
                245                 250                 255     


Leu Ile Leu Val Val Ile Leu Val Leu Leu Thr Val Leu Ala Leu Leu 
            260                 265                 270         


Ser His Arg Arg Ala Leu Lys Gln Lys Ile Trp Pro Gly Ile Pro Ser 
        275                 280                 285             


Pro Glu Ser Glu Phe Glu Gly Leu Phe Thr Thr His Lys Gly Asn Phe 
    290                 295                 300                 


Gln Leu Trp Leu Tyr Gln Asn Asp Gly Cys Leu Trp Trp Ser Pro Cys 
305                 310                 315                 320 


Thr Pro Phe Thr Glu Asp Pro Pro Ala Ser Leu Glu Val Leu Ser Glu 
                325                 330                 335     


Arg Cys Trp Gly Thr Met Gln Ala Val Glu Pro Gly Thr Asp Asp Glu 
            340                 345                 350         


Gly Pro Leu Leu Glu Pro Val Gly Ser Glu His Ala Gln Asp Thr Tyr 
        355                 360                 365             


Leu Val Leu Asp Lys Trp Leu Leu Pro Arg Asn Pro Pro Ser Glu Asp 
    370                 375                 380                 


Leu Pro Gly Pro Gly Gly Ser Val Asp Ile Val Ala Met Asp Glu Gly 
385                 390                 395                 400 


Ser Glu Ala Ser Ser Cys Ser Ser Ala Leu Ala Ser Lys Pro Ser Pro 
                405                 410                 415     


Glu Gly Ala Ser Ala Ala Ser Phe Glu Tyr Thr Ile Leu Asp Pro Ser 
            420                 425                 430         


Ser Gln Leu Leu Arg Pro Trp Thr Leu Cys Pro Glu Leu Pro Pro Thr 
        435                 440                 445             


Pro Pro His Leu Lys Tyr Leu Tyr Leu Val Val Ser Asp Ser Gly Ile 
    450                 455                 460                 


Ser Thr Asp Tyr Ser Ser Gly Asp Ser Gln Gly Ala Gln Gly Gly Leu 
465                 470                 475                 480 


Ser Asp Gly Pro Tyr Ser Asn Pro Tyr Glu Asn Ser Leu Ile Pro Ala 
                485                 490                 495     


Ala Glu Pro Leu Pro Pro Ser Tyr Val Ala Cys Ser 
            500                 505             


<210>  331
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr 
625                 630                 635                 640 


Cys Leu Cys Gly Thr Ala Trp Leu Cys Cys Ser Pro Asn Arg Lys Asn 
                645                 650                 655     


Pro Leu Trp Pro Ser Val Pro Asp Pro Ala His Ser Ser Leu Gly Ser 
            660                 665                 670         


Trp Val Pro Thr Ile Met Glu Glu Asp Ala Phe Gln Leu Pro Gly Leu 
        675                 680                 685             


Gly Thr Pro Pro Ile Thr Lys Leu Thr Val Leu Glu Glu Asp Glu Lys 
    690                 695                 700                 


Lys Pro Val Pro Trp Glu Ser His Asn Ser Ser Glu Thr Cys Gly Leu 
705                 710                 715                 720 


Pro Thr Leu Val Gln Thr Tyr Val Leu Gln Gly Asp Pro Arg Ala Val 
                725                 730                 735     


Ser Thr Gln Pro Gln Ser Gln Ser Gly Thr Ser Asp Gln Val Leu Tyr 
            740                 745                 750         


Gly Gln Leu Leu Gly Ser Pro Thr Ser Pro Gly Pro Gly His Tyr Leu 
        755                 760                 765             


Arg Cys Asp Ser Thr Gln Pro Leu Leu Ala Gly Leu Thr Pro Ser Pro 
    770                 775                 780                 


Lys Ser Tyr Glu Asn Leu Trp Phe Gln Ala Ser Pro Leu Gly Thr Leu 
785                 790                 795                 800 


Val Thr Pro Ala Pro Ser Gln Glu Asp Asp Cys Val Phe Gly Pro Leu 
                805                 810                 815     


Leu Asn Phe Pro Leu Leu Gln Gly Ile Arg Val His Gly Met Glu Ala 
            820                 825                 830         


Leu Gly Ser Phe 
        835     


<210>  332
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  333
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Lys Glu Asn Val Ala Ser Ala Thr Val Phe Thr Leu Leu Leu Phe 
1               5                   10                  15      


Leu Asn Thr Cys Leu Leu Asn Gly Gln Leu Pro Pro Gly Lys Pro Glu 
            20                  25                  30          


Ile Phe Lys Cys Arg Ser Pro Asn Lys Glu Thr Phe Thr Cys Trp Trp 
        35                  40                  45              


Arg Pro Gly Thr Asp Gly Gly Leu Pro Thr Asn Tyr Ser Leu Thr Tyr 
    50                  55                  60                  


His Arg Glu Gly Glu Thr Leu Met His Glu Cys Pro Asp Tyr Ile Thr 
65                  70                  75                  80  


Gly Gly Pro Asn Ser Cys His Phe Gly Lys Gln Tyr Thr Ser Met Trp 
                85                  90                  95      


Arg Thr Tyr Ile Met Met Val Asn Ala Thr Asn Gln Met Gly Ser Ser 
            100                 105                 110         


Phe Ser Asp Glu Leu Tyr Val Asp Val Thr Tyr Ile Val Gln Pro Asp 
        115                 120                 125             


Pro Pro Leu Glu Leu Ala Val Glu Val Lys Gln Pro Glu Asp Arg Lys 
    130                 135                 140                 


Pro Tyr Leu Trp Ile Lys Trp Ser Pro Pro Thr Leu Ile Asp Leu Lys 
145                 150                 155                 160 


Thr Gly Trp Phe Thr Leu Leu Tyr Glu Ile Arg Leu Lys Pro Glu Lys 
                165                 170                 175     


Ala Ala Glu Trp Glu Ile His Phe Ala Gly Gln Gln Thr Glu Phe Lys 
            180                 185                 190         


Ile Leu Ser Leu His Pro Gly Gln Lys Tyr Leu Val Gln Val Arg Cys 
        195                 200                 205             


Lys Pro Asp His Gly Tyr Trp Ser Ala Trp Ser Pro Ala Thr Phe Ile 
    210                 215                 220                 


Gln Ile Pro Ser Asp Phe Thr Met Asn Asp Thr Thr Val Trp Ile Ser 
225                 230                 235                 240 


Val Ala Val Leu Ser Ala Val Ile Cys Leu Ile Ile Val Trp Ala Val 
                245                 250                 255     


Ala Leu Lys Gly Tyr Ser Met Val Thr Cys Ile Phe Pro Pro Val Pro 
            260                 265                 270         


Gly Pro Lys Ile Lys Gly Phe Asp Ala His Leu Leu Glu Lys Gly Lys 
        275                 280                 285             


Ser Glu Glu Leu Leu Ser Ala Leu Gly Cys Gln Asp Phe Pro Pro Thr 
    290                 295                 300                 


Ser Asp Tyr Glu Asp Leu Leu Val Glu Tyr Leu Glu Val Asp Asp Ser 
305                 310                 315                 320 


Glu Asp Gln His Leu Met Ser Val His Ser Lys Glu His Pro Ser Gln 
                325                 330                 335     


Gly Met Lys Pro Thr Tyr Leu Asp Pro Asp Thr Asp Ser Gly Arg Gly 
            340                 345                 350         


Ser Cys Asp Ser Pro Ser Leu Leu Ser Glu Lys Cys Glu Glu Pro Gln 
        355                 360                 365             


Ala Asn Pro Ser Thr Phe Tyr Asp Pro Glu Val Ile Glu Lys Pro Glu 
    370                 375                 380                 


Asn Pro Glu Thr Thr His Thr Trp Asp Pro Gln Cys Ile Ser Met Glu 
385                 390                 395                 400 


Gly Lys Ile Pro Tyr Phe His Ala Gly Gly Ser Lys Cys Ser Thr Trp 
                405                 410                 415     


Pro Leu Pro Gln Pro Ser Gln His Asn Pro Arg Ser Ser Tyr His Asn 
            420                 425                 430         


Ile Thr Asp Val Cys Glu Leu Ala Val Gly Pro Ala Gly Ala Pro Ala 
        435                 440                 445             


Thr Leu Leu Asn Glu Ala Gly Lys Asp Ala Leu Lys Ser Ser Gln Thr 
    450                 455                 460                 


Ile Lys Ser Arg Glu Glu Gly Lys Ala Thr Gln Gln Arg Glu Val Glu 
465                 470                 475                 480 


Ser Phe His Ser Glu Thr Asp Gln Asp Thr Pro Trp Leu Leu Pro Gln 
                485                 490                 495     


Glu Lys Thr Pro Phe Gly Ser Ala Lys Pro Leu Asp Tyr Val Glu Ile 
            500                 505                 510         


His Lys Val Asn Lys Asp Gly Ala Leu Ser Leu Leu Pro Lys Gln Arg 
        515                 520                 525             


Glu Asn Ser Gly Lys Pro Lys Lys Pro Gly Thr Pro Glu Asn Asn Lys 
    530                 535                 540                 


Glu Tyr Ala Lys Val Ser Gly Val Met Asp Asn Asn Ile Leu Val Leu 
545                 550                 555                 560 


Val Pro Asp Pro His Ala Lys Asn Val Ala Cys Phe Glu Glu Ser Ala 
                565                 570                 575     


Lys Glu Ala Pro Pro Ser Leu Glu Gln Asn Gln Ala Glu Lys Ala Leu 
            580                 585                 590         


Ala Asn Phe Thr Ala Thr Ser Ser Lys Cys Arg Leu Gln Leu Gly Gly 
        595                 600                 605             


Leu Asp Tyr Leu Asp Pro Ala Cys Phe Thr His Ser Phe His 
    610                 615                 620         


<210>  334
<211>  635
<212>  PRT
<213>  Homo sapiens

<400>  334

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala 
1               5                   10                  15      


Pro Gln Asn Leu Ala Gln Val Ser Ser Gln Asp Val Ser Leu Leu Ala 
            20                  25                  30          


Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu 
        35                  40                  45              


Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gln 
    50                  55                  60                  


Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser 
65                  70                  75                  80  


Ser Gln Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gln Phe Pro 
                85                  90                  95      


Asp Gln Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys 
            100                 105                 110         


Asn Val Phe Leu Asn Gln Thr Arg Thr Gln Arg Val Leu Phe Val Asp 
        115                 120                 125             


Ser Val Gly Leu Pro Ala Pro Pro Ser Ile Ile Lys Ala Met Gly Gly 
    130                 135                 140                 


Ser Gln Pro Gly Glu Leu Gln Ile Ser Trp Glu Glu Pro Ala Pro Glu 
145                 150                 155                 160 


Ile Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro 
                165                 170                 175     


Lys Asn Ser Thr Gly Pro Thr Val Ile Gln Leu Ile Ala Thr Glu Thr 
            180                 185                 190         


Cys Cys Pro Ala Leu Gln Arg Pro His Ser Ala Ser Ala Leu Asp Gln 
        195                 200                 205             


Ser Pro Cys Ala Gln Pro Thr Met Pro Trp Gln Asp Gly Pro Lys Gln 
    210                 215                 220                 


Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser 
225                 230                 235                 240 


Cys Leu Ile Ser Gly Leu Gln Pro Gly Asn Ser Tyr Trp Leu Gln Leu 
                245                 250                 255     


Arg Ser Glu Pro Asp Gly Ile Ser Leu Gly Gly Ser Trp Gly Ser Trp 
            260                 265                 270         


Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly 
        275                 280                 285             


Leu Gln Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gln Trp Gln 
    290                 295                 300                 


Gln Gln Asp His Ala Ser Ser Gln Gly Phe Phe Tyr His Ser Arg Ala 
305                 310                 315                 320 


Arg Cys Cys Pro Arg Asp Arg Tyr Pro Ile Trp Glu Asn Cys Glu Glu 
                325                 330                 335     


Glu Glu Lys Thr Asn Pro Gly Leu Gln Thr Pro Gln Phe Ser Arg Cys 
            340                 345                 350         


His Phe Lys Ser Arg Asn Asp Ser Ile Ile His Ile Leu Val Glu Val 
        355                 360                 365             


Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp 
    370                 375                 380                 


Ile His Gln Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu 
385                 390                 395                 400 


Ile Ser Ser Gly His Leu Glu Leu Glu Trp Gln His Pro Ser Ser Trp 
                405                 410                 415     


Ala Ala Gln Glu Thr Cys Tyr Gln Leu Arg Tyr Thr Gly Glu Gly His 
            420                 425                 430         


Gln Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr 
        435                 440                 445             


Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gln Leu Arg Ala Arg 
    450                 455                 460                 


Leu Asn Gly Pro Thr Tyr Gln Gly Pro Trp Ser Ser Trp Ser Asp Pro 
465                 470                 475                 480 


Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp Ile Ser Leu Val Thr 
                485                 490                 495     


Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu 
            500                 505                 510         


Leu Arg Trp Gln Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu 
        515                 520                 525             


Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gln Tyr Leu Arg 
    530                 535                 540                 


Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys 
545                 550                 555                 560 


Glu Glu Val Glu Pro Ser Leu Leu Glu Ile Leu Pro Lys Ser Ser Glu 
                565                 570                 575     


Arg Thr Pro Leu Pro Leu Cys Ser Ser Gln Ala Gln Met Asp Tyr Arg 
            580                 585                 590         


Arg Leu Gln Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro 
        595                 600                 605             


Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His Ile Ala Asn His 
    610                 615                 620                 


Ser Tyr Leu Pro Leu Ser Tyr Trp Gln Gln Pro 
625                 630                 635 


<210>  335
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Met Val Val Leu Leu Gly Ala Thr Thr Leu Val Leu Val Ala Val 
1               5                   10                  15      


Ala Pro Trp Val Leu Ser Ala Ala Ala Gly Gly Lys Asn Leu Lys Ser 
            20                  25                  30          


Pro Gln Lys Val Glu Val Asp Ile Ile Asp Asp Asn Phe Ile Leu Arg 
        35                  40                  45              


Trp Asn Arg Ser Asp Glu Ser Val Gly Asn Val Thr Phe Ser Phe Asp 
    50                  55                  60                  


Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile Lys Leu Ser Gly Cys Gln 
65                  70                  75                  80  


Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser Ser Leu Lys Leu Asn Val 
                85                  90                  95      


Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala Glu Lys Glu Asn Thr Ser 
            100                 105                 110         


Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro Phe Arg Lys Ala Gln Ile 
        115                 120                 125             


Gly Pro Pro Glu Val His Leu Glu Ala Glu Asp Lys Ala Ile Val Ile 
    130                 135                 140                 


His Ile Ser Pro Gly Thr Lys Asp Ser Val Met Trp Ala Leu Asp Gly 
145                 150                 155                 160 


Leu Ser Phe Thr Tyr Ser Leu Val Ile Trp Lys Asn Ser Ser Gly Val 
                165                 170                 175     


Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg His Lys Ile Tyr Lys Leu 
            180                 185                 190         


Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val Lys Ala Ala Leu Leu Thr 
        195                 200                 205             


Ser Trp Lys Ile Gly Val Tyr Ser Pro Val His Cys Ile Lys Thr Thr 
    210                 215                 220                 


Val Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
225                 230                 235                 240 


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
                245                 250                 255     


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
            260                 265                 270         


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
        275                 280                 285             


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
    290                 295                 300                 


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
305                 310                 315                 320 


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
                325                 330                 335     


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
            340                 345                 350         


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
        355                 360                 365             


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
    370                 375                 380                 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
385                 390                 395                 400 


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
                405                 410                 415     


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
            420                 425                 430         


Asn Thr Ser Lys Ile Trp Leu Ile Val Gly Ile Cys Ile Ala Leu Phe 
        435                 440                 445             


Ala Leu Pro Phe Val Ile Tyr Ala Ala Lys Val Phe Leu Arg Cys Ile 
    450                 455                 460                 


Asn Tyr Val Phe Phe Pro Ser Leu Lys Pro Ser Ser Ser Ile Asp Glu 
465                 470                 475                 480 


Tyr Phe Ser Glu Gln Pro Leu Lys Asn Leu Leu Leu Ser Thr Ser Glu 
                485                 490                 495     


Glu Gln Ile Glu Lys Cys Phe Ile Ile Glu Asn Ile Ser Thr Ile Ala 
            500                 505                 510         


Thr Val Glu Glu Thr Asn Gln Thr Asp Glu Asp His Lys Lys Tyr Ser 
        515                 520                 525             


Ser Gln Thr Ser Gln Asp Ser Gly Asn Tyr Ser Asn Glu Asp Glu Ser 
    530                 535                 540                 


Glu Ser Lys Thr Ser Glu Glu Leu Gln Gln Asp Phe Val 
545                 550                 555         


<210>  336
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Leu Leu Ser Gln Asn Ala Phe Ile Phe Arg Ser Leu Asn Leu Val 
1               5                   10                  15      


Leu Met Val Tyr Ile Ser Leu Val Phe Gly Ile Ser Tyr Asp Ser Pro 
            20                  25                  30          


Asp Tyr Thr Asp Glu Ser Cys Thr Phe Lys Ile Ser Leu Arg Asn Phe 
        35                  40                  45              


Arg Ser Ile Leu Ser Trp Glu Leu Lys Asn His Ser Ile Val Pro Thr 
    50                  55                  60                  


His Tyr Thr Leu Leu Tyr Thr Ile Met Ser Lys Pro Glu Asp Leu Lys 
65                  70                  75                  80  


Val Val Lys Asn Cys Ala Asn Thr Thr Arg Ser Phe Cys Asp Leu Thr 
                85                  90                  95      


Asp Glu Trp Arg Ser Thr His Glu Ala Tyr Val Thr Val Leu Glu Gly 
            100                 105                 110         


Phe Ser Gly Asn Thr Thr Leu Phe Ser Cys Ser His Asn Phe Trp Leu 
        115                 120                 125             


Ala Ile Asp Met Ser Phe Glu Pro Pro Glu Phe Glu Ile Val Gly Phe 
    130                 135                 140                 


Thr Asn His Ile Asn Val Met Val Lys Phe Pro Ser Ile Val Glu Glu 
145                 150                 155                 160 


Glu Leu Gln Phe Asp Leu Ser Leu Val Ile Glu Glu Gln Ser Glu Gly 
                165                 170                 175     


Ile Val Lys Lys His Lys Pro Glu Ile Lys Gly Asn Met Ser Gly Asn 
            180                 185                 190         


Phe Thr Tyr Ile Ile Asp Lys Leu Ile Pro Asn Thr Asn Tyr Cys Val 
        195                 200                 205             


Ser Val Tyr Leu Glu His Ser Asp Glu Gln Ala Val Ile Lys Ser Pro 
    210                 215                 220                 


Leu Lys Cys Thr Leu Leu Pro Pro Gly Gln Glu Ser Glu Ser Ala Glu 
225                 230                 235                 240 


Ser Ala Lys Ile Gly Gly Ile Ile Thr Val Phe Leu Ile Ala Leu Val 
                245                 250                 255     


Leu Thr Ser Thr Ile Val Thr Leu Lys Trp Ile Gly Tyr Ile Cys Leu 
            260                 265                 270         


Arg Asn Ser Leu Pro Lys Val Leu Arg Gln Gly Leu Ala Lys Gly Trp 
        275                 280                 285             


Asn Ala Val Ala Ile His Arg Cys Ser His Asn Ala Leu Gln Ser Glu 
    290                 295                 300                 


Thr Pro Glu Leu Lys Gln Ser Ser Cys Leu Ser Phe Pro Ser Ser Trp 
305                 310                 315                 320 


Asp Tyr Lys Arg Ala Ser Leu Cys Pro Ser Asp 
                325                 330     


<210>  337
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  337

Met Ala Leu Leu Phe Leu Leu Pro Leu Val Met Gln Gly Val Ser Arg 
1               5                   10                  15      


Ala Glu Met Gly Thr Ala Asp Leu Gly Pro Ser Ser Val Pro Thr Pro 
            20                  25                  30          


Thr Asn Val Thr Ile Glu Ser Tyr Asn Met Asn Pro Ile Val Tyr Trp 
        35                  40                  45              


Glu Tyr Gln Ile Met Pro Gln Val Pro Val Phe Thr Val Glu Val Lys 
    50                  55                  60                  


Asn Tyr Gly Val Lys Asn Ser Glu Trp Ile Asp Ala Cys Ile Asn Ile 
65                  70                  75                  80  


Ser His His Tyr Cys Asn Ile Ser Asp His Val Gly Asp Pro Ser Asn 
                85                  90                  95      


Ser Leu Trp Val Arg Val Lys Ala Arg Val Gly Gln Lys Glu Ser Ala 
            100                 105                 110         


Tyr Ala Lys Ser Glu Glu Phe Ala Val Cys Arg Asp Gly Lys Ile Gly 
        115                 120                 125             


Pro Pro Lys Leu Asp Ile Arg Lys Glu Glu Lys Gln Ile Met Ile Asp 
    130                 135                 140                 


Ile Phe His Pro Ser Val Phe Val Asn Gly Asp Glu Gln Glu Val Asp 
145                 150                 155                 160 


Tyr Asp Pro Glu Thr Thr Cys Tyr Ile Arg Val Tyr Asn Val Tyr Val 
                165                 170                 175     


Arg Met Asn Gly Ser Glu Ile Gln Tyr Lys Ile Leu Thr Gln Lys Glu 
            180                 185                 190         


Asp Asp Cys Asp Glu Ile Gln Cys Gln Leu Ala Ile Pro Val Ser Ser 
        195                 200                 205             


Leu Asn Ser Gln Tyr Cys Val Ser Ala Glu Gly Val Leu His Val Trp 
    210                 215                 220                 


Gly Val Thr Thr Glu Lys Ser Lys Glu Val Cys Ile Thr Ile Phe Asn 
225                 230                 235                 240 


Ser Ser Ile Lys Gly Ser Leu Trp Ile Pro Val Val Ala Ala Leu Leu 
                245                 250                 255     


Leu Phe Leu Val Leu Ser Leu Val Phe Ile Cys Phe Tyr Ile Lys Lys 
            260                 265                 270         


Ile Asn Pro Leu Lys Glu Lys Ser Ile Ile Leu Pro Lys Ser Leu Ile 
        275                 280                 285             


Ser Val Val Arg Ser Ala Thr Leu Glu Thr Lys Pro Glu Ser Lys Tyr 
    290                 295                 300                 


Val Ser Leu Ile Thr Ser Tyr Gln Pro Phe Ser Leu Glu Lys Glu Val 
305                 310                 315                 320 


Val Cys Glu Glu Pro Leu Ser Pro Ala Thr Val Pro Gly Met His Thr 
                325                 330                 335     


Glu Asp Asn Pro Gly Lys Val Glu His Thr Glu Glu Leu Ser Ser Ile 
            340                 345                 350         


Thr Glu Val Val Thr Thr Glu Glu Asn Ile Pro Asp Val Val Pro Gly 
        355                 360                 365             


Ser His Leu Thr Pro Ile Glu Arg Glu Ser Ser Ser Pro Leu Ser Ser 
    370                 375                 380                 


Asn Gln Ser Glu Pro Gly Ser Ile Ala Leu Asn Ser Tyr His Ser Arg 
385                 390                 395                 400 


Asn Cys Ser Glu Ser Asp His Ser Arg Asn Gly Phe Asp Thr Asp Ser 
                405                 410                 415     


Ser Cys Leu Glu Ser His Ser Ser Leu Ser Asp Ser Glu Phe Pro Pro 
            420                 425                 430         


Asn Asn Lys Gly Glu Ile Lys Thr Glu Gly Gln Glu Leu Ile Thr Val 
        435                 440                 445             


Ile Lys Ala Pro Thr Ser Phe Gly Tyr Asp Lys Pro His Val Leu Val 
    450                 455                 460                 


Asp Leu Leu Val Asp Asp Ser Gly Lys Glu Ser Leu Ile Gly Tyr Arg 
465                 470                 475                 480 


Pro Thr Glu Asp Ser Lys Glu Phe Ser 
                485                 


<210>  338
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  338

Met Arg Pro Thr Leu Leu Trp Ser Leu Leu Leu Leu Leu Gly Val Phe 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Pro Pro Asp Pro Leu Ser Gln Leu Pro Ala 
            20                  25                  30          


Pro Gln His Pro Lys Ile Arg Leu Tyr Asn Ala Glu Gln Val Leu Ser 
        35                  40                  45              


Trp Glu Pro Val Ala Leu Ser Asn Ser Thr Arg Pro Val Val Tyr Gln 
    50                  55                  60                  


Val Gln Phe Lys Tyr Thr Asp Ser Lys Trp Phe Thr Ala Asp Ile Met 
65                  70                  75                  80  


Ser Ile Gly Val Asn Cys Thr Gln Ile Thr Ala Thr Glu Cys Asp Phe 
                85                  90                  95      


Thr Ala Ala Ser Pro Ser Ala Gly Phe Pro Met Asp Phe Asn Val Thr 
            100                 105                 110         


Leu Arg Leu Arg Ala Glu Leu Gly Ala Leu His Ser Ala Trp Val Thr 
        115                 120                 125             


Met Pro Trp Phe Gln His Tyr Arg Asn Val Thr Val Gly Pro Pro Glu 
    130                 135                 140                 


Asn Ile Glu Val Thr Pro Gly Glu Gly Ser Leu Ile Ile Arg Phe Ser 
145                 150                 155                 160 


Ser Pro Phe Asp Ile Ala Asp Thr Ser Thr Ala Phe Phe Cys Tyr Tyr 
                165                 170                 175     


Val His Tyr Trp Glu Lys Gly Gly Ile Gln Gln Val Lys Gly Pro Phe 
            180                 185                 190         


Arg Ser Asn Ser Ile Ser Leu Asp Asn Leu Lys Pro Ser Arg Val Tyr 
        195                 200                 205             


Cys Leu Gln Val Gln Ala Gln Leu Leu Trp Asn Lys Ser Asn Ile Phe 
    210                 215                 220                 


Arg Val Gly His Leu Ser Asn Ile Ser Cys Tyr Glu Thr Met Ala Asp 
225                 230                 235                 240 


Ala Ser Thr Glu Leu Gln Gln Val Ile Leu Ile Ser Val Gly Thr Phe 
                245                 250                 255     


Ser Leu Leu Ser Val Leu Ala Gly Ala Cys Phe Phe Leu Val Leu Lys 
            260                 265                 270         


Tyr Arg Gly Leu Ile Lys Tyr Trp Phe His Thr Pro Pro Ser Ile Pro 
        275                 280                 285             


Leu Gln Ile Glu Glu Tyr Leu Lys Asp Pro Thr Gln Pro Ile Leu Glu 
    290                 295                 300                 


Ala Leu Asp Lys Asp Ser Ser Pro Lys Asp Asp Val Trp Asp Ser Val 
305                 310                 315                 320 


Ser Ile Ile Ser Phe Pro Glu Lys Glu Gln Glu Asp Val Leu Gln Thr 
                325                 330                 335     


Leu 
    


<210>  339
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  339

Met Met Pro Lys His Cys Phe Leu Gly Phe Leu Ile Ser Phe Phe Leu 
1               5                   10                  15      


Thr Gly Val Ala Gly Thr Gln Ser Thr His Glu Ser Leu Lys Pro Gln 
            20                  25                  30          


Arg Val Gln Phe Gln Ser Arg Asn Phe His Asn Ile Leu Gln Trp Gln 
        35                  40                  45              


Pro Gly Arg Ala Leu Thr Gly Asn Ser Ser Val Tyr Phe Val Gln Tyr 
    50                  55                  60                  


Lys Ile Met Phe Ser Cys Ser Met Lys Ser Ser His Gln Lys Pro Ser 
65                  70                  75                  80  


Gly Cys Trp Gln His Ile Ser Cys Asn Phe Pro Gly Cys Arg Thr Leu 
                85                  90                  95      


Ala Lys Tyr Gly Gln Arg Gln Trp Lys Asn Lys Glu Asp Cys Trp Gly 
            100                 105                 110         


Thr Gln Glu Leu Ser Cys Asp Leu Thr Ser Glu Thr Ser Asp Ile Gln 
        115                 120                 125             


Glu Pro Tyr Tyr Gly Arg Val Arg Ala Ala Ser Ala Gly Ser Tyr Ser 
    130                 135                 140                 


Glu Trp Ser Met Thr Pro Arg Phe Thr Pro Trp Trp Glu Thr Lys Ile 
145                 150                 155                 160 


Asp Pro Pro Val Met Asn Ile Thr Gln Val Asn Gly Ser Leu Leu Val 
                165                 170                 175     


Ile Leu His Ala Pro Asn Leu Pro Tyr Arg Tyr Gln Lys Glu Lys Asn 
            180                 185                 190         


Val Ser Ile Glu Asp Tyr Tyr Glu Leu Leu Tyr Arg Val Phe Ile Ile 
        195                 200                 205             


Asn Asn Ser Leu Glu Lys Glu Gln Lys Val Tyr Glu Gly Ala His Arg 
    210                 215                 220                 


Ala Val Glu Ile Glu Ala Leu Thr Pro His Ser Ser Tyr Cys Val Val 
225                 230                 235                 240 


Ala Glu Ile Tyr Gln Pro Met Leu Asp Arg Arg Ser Gln Arg Ser Glu 
                245                 250                 255     


Glu Arg Cys Val Glu Ile Pro 
            260             


<210>  340
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210>  341
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  341

Met Ala Trp Ser Leu Gly Ser Trp Leu Gly Gly Cys Leu Leu Val Ser 
1               5                   10                  15      


Ala Leu Gly Met Val Pro Pro Pro Glu Asn Val Arg Met Asn Ser Val 
            20                  25                  30          


Asn Phe Lys Asn Ile Leu Gln Trp Glu Ser Pro Ala Phe Ala Lys Gly 
        35                  40                  45              


Asn Leu Thr Phe Thr Ala Gln Tyr Leu Ser Tyr Arg Ile Phe Gln Asp 
    50                  55                  60                  


Lys Cys Met Asn Thr Thr Leu Thr Glu Cys Asp Phe Ser Ser Leu Ser 
65                  70                  75                  80  


Lys Tyr Gly Asp His Thr Leu Arg Val Arg Ala Glu Phe Ala Asp Glu 
                85                  90                  95      


His Ser Asp Trp Val Asn Ile Thr Phe Cys Pro Val Asp Asp Thr Ile 
            100                 105                 110         


Ile Gly Pro Pro Gly Met Gln Val Glu Val Leu Ala Asp Ser Leu His 
        115                 120                 125             


Met Arg Phe Leu Ala Pro Lys Ile Glu Asn Glu Tyr Glu Thr Trp Thr 
    130                 135                 140                 


Met Lys Asn Val Tyr Asn Ser Trp Thr Tyr Asn Val Gln Tyr Trp Lys 
145                 150                 155                 160 


Asn Gly Thr Asp Glu Lys Phe Gln Ile Thr Pro Gln Tyr Asp Phe Glu 
                165                 170                 175     


Val Leu Arg Asn Leu Glu Pro Trp Thr Thr Tyr Cys Val Gln Val Arg 
            180                 185                 190         


Gly Phe Leu Pro Asp Arg Asn Lys Ala Gly Glu Trp Ser Glu Pro Val 
        195                 200                 205             


Cys Glu Gln Thr Thr His Asp Glu Thr Val Pro Ser Trp Met Val Ala 
    210                 215                 220                 


Val Ile Leu Met Ala Ser Val Phe Met Val Cys Leu Ala Leu Leu Gly 
225                 230                 235                 240 


Cys Phe Ala Leu Leu Trp Cys Val Tyr Lys Lys Thr Lys Tyr Ala Phe 
                245                 250                 255     


Ser Pro Arg Asn Ser Leu Pro Gln His Leu Lys Glu Phe Leu Gly His 
            260                 265                 270         


Pro His His Asn Thr Leu Leu Phe Phe Ser Phe Pro Leu Ser Asp Glu 
        275                 280                 285             


Asn Asp Val Phe Asp Lys Leu Ser Val Ile Ala Glu Asp Ser Glu Ser 
    290                 295                 300                 


Gly Lys Gln Asn Pro Gly Asp Ser Cys Ser Leu Gly Thr Pro Pro Gly 
305                 310                 315                 320 


Gln Gly Pro Gln Ser 
                325 


<210>  342
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  342

Met Lys Asn Val Leu Gln Trp Thr Pro Pro Glu Gly Leu Gln Gly Val 
1               5                   10                  15      


Lys Val Thr Tyr Thr Val Gln Tyr Phe Ile Tyr Gly Gln Lys Lys Trp 
            20                  25                  30          


Leu Asn Lys Ser Glu Cys Arg Asn Ile Asn Arg Thr Tyr Cys Asp Leu 
        35                  40                  45              


Ser Ala Glu Thr Ser Asp Tyr Glu His Gln Tyr Tyr Ala Lys Val Lys 
    50                  55                  60                  


Ala Ile Trp Gly Thr Lys Cys Ser Lys Trp Ala Glu Ser Gly Arg Phe 
65                  70                  75                  80  


Tyr Pro Phe Leu Glu Thr Gln Ile Gly Pro Pro Glu Val Ala Leu Thr 
                85                  90                  95      


Thr Asp Glu Lys Ser Ile Ser Val Val Leu Thr Ala Pro Glu Lys Trp 
            100                 105                 110         


Lys Arg Asn Pro Glu Asp Leu Pro Val Ser Met Gln Gln Ile Tyr Ser 
        115                 120                 125             


Asn Leu Lys Tyr Asn Val Ser Val Leu Asn Thr Lys Ser Asn Arg Thr 
    130                 135                 140                 


Trp Ser Gln Cys Val Thr Asn His Thr Leu Val Leu Thr Trp Leu Glu 
145                 150                 155                 160 


Pro Asn Thr Leu Tyr Cys Val His Val Glu Ser Phe Val Pro Gly Pro 
                165                 170                 175     


Pro Arg Arg Ala Gln Pro Ser Glu Lys Gln Cys Ala Arg Thr Leu Lys 
            180                 185                 190         


Asp Gln Ser Ser Glu Phe Lys Ala Lys Ile Ile Phe Trp Tyr Val Leu 
        195                 200                 205             


Pro Ile Ser Ile Thr Val Phe Leu Phe Ser Val Met Gly Tyr Ser Ile 
    210                 215                 220                 


Tyr Arg Tyr Ile His Val Gly Lys Glu Lys His Pro Ala Asn Leu Ile 
225                 230                 235                 240 


Leu Ile Tyr Gly Asn Glu Phe Asp Lys Arg Phe Phe Val Pro Ala Glu 
                245                 250                 255     


Lys Ile Val Ile Asn Phe Ile Thr Leu Asn Ile Ser Asp Asp Ser Lys 
            260                 265                 270         


Ile Ser His Gln Asp Met Ser Leu Leu Gly Lys Ser Ser Asp Val Ser 
        275                 280                 285             


Ser Leu Asn Asp Pro Gln Pro Ser Gly Asn Leu Arg Pro Pro Gln Glu 
    290                 295                 300                 


Glu Glu Glu Val Lys His Leu Gly Tyr Ala Ser His Leu Met Glu Ile 
305                 310                 315                 320 


Phe Cys Asp Ser Glu Glu Asn Thr Glu Gly Thr Ser Leu Thr Gln Gln 
                325                 330                 335     


Glu Ser Leu Ser Arg Thr Ile Pro Pro Asp Lys Thr Val Ile Glu Tyr 
            340                 345                 350         


Glu Tyr Asp Val Arg Thr Thr Asp Ile Cys Ala Gly Pro Glu Glu Gln 
        355                 360                 365             


Glu Leu Ser Leu Gln Glu Glu Val Ser Thr Gln Gly Thr Leu Leu Glu 
    370                 375                 380                 


Ser Gln Ala Ala Leu Ala Val Leu Gly Pro Gln Thr Leu Gln Tyr Ser 
385                 390                 395                 400 


Tyr Thr Pro Gln Leu Gln Asp Leu Asp Pro Leu Ala Gln Glu His Thr 
                405                 410                 415     


Asp Ser Glu Glu Gly Pro Glu Glu Glu Pro Ser Thr Thr Leu Val Asp 
            420                 425                 430         


Trp Asp Pro Gln Thr Gly Arg Leu Cys Ile Pro Ser Leu Ser Ser Phe 
        435                 440                 445             


Asp Gln Asp Ser Glu Gly Cys Glu Pro Ser Glu Gly Asp Gly Leu Gly 
    450                 455                 460                 


Glu Glu Gly Leu Leu Ser Arg Leu Tyr Glu Glu Pro Ala Pro Asp Arg 
465                 470                 475                 480 


Pro Pro Gly Glu Asn Glu Thr Tyr Leu Met Gln Phe Met Glu Glu Trp 
                485                 490                 495     


Gly Leu Tyr Val Gln Met Glu Asn 
            500                 


<210>  343
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Gln Thr Phe Thr Met Val Leu Glu Glu Ile Trp Thr Ser Leu Phe 
1               5                   10                  15      


Met Trp Phe Phe Tyr Ala Leu Ile Pro Cys Leu Leu Thr Asp Glu Val 
            20                  25                  30          


Ala Ile Leu Pro Ala Pro Gln Asn Leu Ser Val Leu Ser Thr Asn Met 
        35                  40                  45              


Lys His Leu Leu Met Trp Ser Pro Val Ile Ala Pro Gly Glu Thr Val 
    50                  55                  60                  


Tyr Tyr Ser Val Glu Tyr Gln Gly Glu Tyr Glu Ser Leu Tyr Thr Ser 
65                  70                  75                  80  


His Ile Trp Ile Pro Ser Ser Trp Cys Ser Leu Thr Glu Gly Pro Glu 
                85                  90                  95      


Cys Asp Val Thr Asp Asp Ile Thr Ala Thr Val Pro Tyr Asn Leu Arg 
            100                 105                 110         


Val Arg Ala Thr Leu Gly Ser Gln Thr Ser Ala Trp Ser Ile Leu Lys 
        115                 120                 125             


His Pro Phe Asn Arg Asn Ser Thr Ile Leu Thr Arg Pro Gly Met Glu 
    130                 135                 140                 


Ile Thr Lys Asp Gly Phe His Leu Val Ile Glu Leu Glu Asp Leu Gly 
145                 150                 155                 160 


Pro Gln Phe Glu Phe Leu Val Ala Tyr Trp Arg Arg Glu Pro Gly Ala 
                165                 170                 175     


Glu Glu His Val Lys Met Val Arg Ser Gly Gly Ile Pro Val His Leu 
            180                 185                 190         


Glu Thr Met Glu Pro Gly Ala Ala Tyr Cys Val Lys Ala Gln Thr Phe 
        195                 200                 205             


Val Lys Ala Ile Gly Arg Tyr Ser Ala Phe Ser Gln Thr Glu Cys Val 
    210                 215                 220                 


Glu Val Gln Gly Glu Ala Ile Pro Leu Val Leu Ala Leu Phe Ala Phe 
225                 230                 235                 240 


Val Gly Phe Met Leu Ile Leu Val Val Val Pro Leu Phe Val Trp Lys 
                245                 250                 255     


Met Gly Arg Leu Leu Gln Tyr Ser Cys Cys Pro Val Val Val Leu Pro 
            260                 265                 270         


Asp Thr Leu Lys Ile Thr Asn Ser Pro Gln Lys Leu Ile Ser Cys Arg 
        275                 280                 285             


Arg Glu Glu Val Asp Ala Cys Ala Thr Ala Val Met Ser Pro Glu Glu 
    290                 295                 300                 


Leu Leu Arg Ala Trp Ile Ser 
305                 310     


<210>  344
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  344

Met Arg Thr Leu Leu Thr Ile Leu Thr Val Gly Ser Leu Ala Ala His 
1               5                   10                  15      


Ala Pro Glu Asp Pro Ser Asp Leu Leu Gln His Val Lys Phe Gln Ser 
            20                  25                  30          


Ser Asn Phe Glu Asn Ile Leu Thr Trp Asp Ser Gly Pro Glu Gly Thr 
        35                  40                  45              


Pro Asp Thr Val Tyr Ser Ile Glu Tyr Lys Thr Tyr Gly Glu Arg Asp 
    50                  55                  60                  


Trp Val Ala Lys Lys Gly Cys Gln Arg Ile Thr Arg Lys Ser Cys Asn 
65                  70                  75                  80  


Leu Thr Val Glu Thr Gly Asn Leu Thr Glu Leu Tyr Tyr Ala Arg Val 
                85                  90                  95      


Thr Ala Val Ser Ala Gly Gly Arg Ser Ala Thr Lys Met Thr Asp Arg 
            100                 105                 110         


Phe Ser Ser Leu Gln His Thr Thr Leu Lys Pro Pro Asp Val Thr Cys 
        115                 120                 125             


Ile Ser Lys Val Arg Ser Ile Gln Met Ile Val His Pro Thr Pro Thr 
    130                 135                 140                 


Pro Ile Arg Ala Gly Asp Gly His Arg Leu Thr Leu Glu Asp Ile Phe 
145                 150                 155                 160 


His Asp Leu Phe Tyr His Leu Glu Leu Gln Val Asn Arg Thr Tyr Gln 
                165                 170                 175     


Met His Leu Gly Gly Lys Gln Arg Glu Tyr Glu Phe Phe Gly Leu Thr 
            180                 185                 190         


Pro Asp Thr Glu Phe Leu Gly Thr Ile Met Ile Cys Val Pro Thr Trp 
        195                 200                 205             


Ala Lys Glu Ser Ala Pro Tyr Met Cys Arg Val Lys Thr Leu Pro Asp 
    210                 215                 220                 


Arg Thr Trp Thr Tyr Ser Phe Ser Gly Ala Phe Leu Phe Ser Met Gly 
225                 230                 235                 240 


Phe Leu Val Ala Val Leu Cys Tyr Leu Ser Tyr Arg Tyr Val Thr Lys 
                245                 250                 255     


Pro Pro Ala Pro Pro Asn Ser Leu Asn Val Gln Arg Val Leu Thr Phe 
            260                 265                 270         


Gln Pro Leu Arg Phe Ile Gln Glu His Val Leu Ile Pro Val Phe Asp 
        275                 280                 285             


Leu Ser Gly Pro Ser Ser Leu Ala Gln Pro Val Gln Tyr Ser Gln Ile 
    290                 295                 300                 


Arg Val Ser Gly Pro Arg Glu Pro Ala Gly Ala Pro Gln Arg His Ser 
305                 310                 315                 320 


Leu Ser Glu Ile Thr Tyr Leu Gly Gln Pro Asp Ile Ser Ile Leu Gln 
                325                 330                 335     


Pro Ser Asn Val Pro Pro Pro Gln Ile Leu Ser Pro Leu Ser Tyr Ala 
            340                 345                 350         


Pro Asn Ala Ala Pro Glu Val Gly Pro Pro Ser Tyr Ala Pro Gln Val 
        355                 360                 365             


Thr Pro Glu Ala Gln Phe Pro Phe Tyr Ala Pro Gln Ala Ile Ser Lys 
    370                 375                 380                 


Val Gln Pro Ser Ser Tyr Ala Pro Gln Ala Thr Pro Asp Ser Trp Pro 
385                 390                 395                 400 


Pro Ser Tyr Gly Val Cys Met Glu Gly Ser Gly Lys Asp Ser Pro Thr 
                405                 410                 415     


Gly Thr Leu Ser Ser Pro Lys His Leu Arg Pro Lys Gly Gln Leu Gln 
            420                 425                 430         


Lys Glu Pro Pro Ala Gly Ser Cys Met Leu Gly Gly Leu Ser Leu Gln 
        435                 440                 445             


Glu Val Thr Ser Leu Ala Met Glu Glu Ser Gln Glu Ala Lys Ser Leu 
    450                 455                 460                 


His Gln Pro Leu Gly Ile Cys Thr Asp Arg Thr Ser Asp Pro Asn Val 
465                 470                 475                 480 


Leu His Ser Gly Glu Glu Gly Thr Pro Gln Tyr Leu Lys Gly Gln Leu 
                485                 490                 495     


Pro Leu Leu Ser Ser Val Gln Ile Glu Gly His Pro Met Ser Leu Pro 
            500                 505                 510         


Leu Gln Pro Pro Ser Arg Pro Cys Ser Pro Ser Asp Gln Gly Pro Ser 
        515                 520                 525             


Pro Trp Gly Leu Leu Glu Ser Leu Val Cys Pro Lys Asp Glu Ala Lys 
    530                 535                 540                 


Ser Pro Ala Pro Glu Thr Ser Asp Leu Glu Gln Pro Thr Glu Leu Asp 
545                 550                 555                 560 


Ser Leu Phe Arg Gly Leu Ala Leu Thr Val Gln Trp Glu Ser 
                565                 570                 


<210>  345
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Ala Gly Pro Glu Arg Trp Gly Pro Leu Leu Leu Cys Leu Leu Gln 
1               5                   10                  15      


Ala Ala Pro Gly Arg Pro Arg Leu Ala Pro Pro Gln Asn Val Thr Leu 
            20                  25                  30          


Leu Ser Gln Asn Phe Ser Val Tyr Leu Thr Trp Leu Pro Gly Leu Gly 
        35                  40                  45              


Asn Pro Gln Asp Val Thr Tyr Phe Val Ala Tyr Gln Ser Ser Pro Thr 
    50                  55                  60                  


Arg Arg Arg Trp Arg Glu Val Glu Glu Cys Ala Gly Thr Lys Glu Leu 
65                  70                  75                  80  


Leu Cys Ser Met Met Cys Leu Lys Lys Gln Asp Leu Tyr Asn Lys Phe 
                85                  90                  95      


Lys Gly Arg Val Arg Thr Val Ser Pro Ser Ser Lys Ser Pro Trp Val 
            100                 105                 110         


Glu Ser Glu Tyr Leu Asp Tyr Leu Phe Glu Val Glu Pro Ala Pro Pro 
        115                 120                 125             


Val Leu Val Leu Thr Gln Thr Glu Glu Ile Leu Ser Ala Asn Ala Thr 
    130                 135                 140                 


Tyr Gln Leu Pro Pro Cys Met Pro Pro Leu Asp Leu Lys Tyr Glu Val 
145                 150                 155                 160 


Ala Phe Trp Lys Glu Gly Ala Gly Asn Lys Thr Leu Phe Pro Val Thr 
                165                 170                 175     


Pro His Gly Gln Pro Val Gln Ile Thr Leu Gln Pro Ala Ala Ser Glu 
            180                 185                 190         


His His Cys Leu Ser Ala Arg Thr Ile Tyr Thr Phe Ser Val Pro Lys 
        195                 200                 205             


Tyr Ser Lys Phe Ser Lys Pro Thr Cys Phe Leu Leu Glu Val Pro Glu 
    210                 215                 220                 


Ala Asn Trp Ala Phe Leu Val Leu Pro Ser Leu Leu Ile Leu Leu Leu 
225                 230                 235                 240 


Val Ile Ala Ala Gly Gly Val Ile Trp Lys Thr Leu Met Gly Asn Pro 
                245                 250                 255     


Trp Phe Gln Arg Ala Lys Met Pro Arg Ala Leu Asp Phe Ser Gly His 
            260                 265                 270         


Thr His Pro Val Ala Thr Phe Gln Pro Ser Arg Pro Glu Ser Val Asn 
        275                 280                 285             


Asp Leu Phe Leu Cys Pro Gln Lys Glu Leu Thr Arg Gly Val Arg Pro 
    290                 295                 300                 


Thr Pro Arg Val Arg Ala Pro Ala Thr Gln Gln Thr Arg Trp Lys Lys 
305                 310                 315                 320 


Asp Leu Ala Glu Asp Glu Glu Glu Glu Asp Glu Glu Asp Thr Glu Asp 
                325                 330                 335     


Gly Val Ser Phe Gln Pro Tyr Ile Glu Pro Pro Ser Phe Leu Gly Gln 
            340                 345                 350         


Glu His Gln Ala Pro Gly His Ser Glu Ala Gly Gly Val Asp Ser Gly 
        355                 360                 365             


Arg Pro Arg Ala Pro Leu Val Pro Ser Glu Gly Ser Ser Ala Trp Asp 
    370                 375                 380                 


Ser Ser Asp Arg Ser Trp Ala Ser Thr Val Asp Ser Ser Trp Asp Arg 
385                 390                 395                 400 


Ala Gly Ser Ser Gly Tyr Leu Ala Glu Lys Gly Pro Gly Gln Gly Pro 
                405                 410                 415     


Gly Gly Asp Gly His Gln Glu Ser Leu Pro Pro Pro Glu Phe Ser Lys 
            420                 425                 430         


Asp Ser Gly Phe Leu Glu Glu Leu Pro Glu Asp Asn Leu Ser Ser Trp 
        435                 440                 445             


Ala Thr Trp Gly Thr Leu Pro Pro Glu Pro Asn Leu Val Pro Gly Gly 
    450                 455                 460                 


Pro Pro Val Ser Leu Gln Thr Leu Thr Phe Cys Trp Glu Ser Ser Pro 
465                 470                 475                 480 


Glu Glu Glu Glu Glu Ala Arg Glu Ser Glu Ile Glu Asp Ser Asp Ala 
                485                 490                 495     


Gly Ser Trp Gly Ala Glu Ser Thr Gln Arg Thr Glu Asp Arg Gly Arg 
            500                 505                 510         


Thr Leu Gly His Tyr Met Ala Arg 
        515                 520 


<210>  346
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  346

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Gly Pro Gly Ser Glu Lys 
305                 310                 315                 320 


Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala Asp Leu 
                325                 330                 335     


Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr Ser Ala 
            340                 345                 350         


Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln Phe Leu 
        355                 360                 365             


Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu Glu Gln 
    370                 375                 380                 


Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln Lys Gln 
385                 390                 395                 400 


Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser Arg Gly 
                405                 410                 415     


Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro Val Arg 
            420                 425                 430         


Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr Ala Ala 
        435                 440                 445             


Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe Gly Thr 
    450                 455                 460                 


Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp Val Pro 
465                 470                 475                 480 


Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg Phe Glu 
                485                 490                 495     


Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro Gly Arg 
            500                 505                 510         


Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg Ser Pro 
        515                 520                 525             


Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp Trp Gln 
    530                 535                 540                 


Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser Ala Asp 
545                 550                 555                 560 


Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu Pro Leu 
                565                 570                 575     


Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val Arg Glu 
            580                 585                 590         


Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly Glu Glu 
        595                 600                 605             


Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro Arg Gly 
    610                 615                 620                 


Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala Glu Glu 
625                 630                 635                 640 


Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp Gly Ala 
                645                 650                 655     


Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro Leu Leu 
            660                 665                 670         


Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro Val Asp 
        675                 680                 685             


Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser Pro Asp 
    690                 695                 700                 


Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met Leu Ser 
705                 710                 715                 720 


Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys Ser Arg 
                725                 730                 735     


Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu Glu Gln 
            740                 745                 750         


Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser Ser Pro 
        755                 760                 765             


Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu Glu Glu 
    770                 775                 780                 


Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp Leu Glu 
785                 790                 795                 800 


Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu Gln Lys 
                805                 810                 815     


Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro Ser Ala 
            820                 825                 830         


<210>  347
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  347

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  348
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Asp Cys Arg Gly Leu Glu Val Trp Asn Ser Ile Pro Ser Cys Trp Ala 
        195                 200                 205             


Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu Val 
    210                 215                 220                 


Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp Asn 
225                 230                 235                 240 


Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr Gly 
                245                 250                 255     


Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu Cys 
            260                 265                 270         


Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile Cys 
        275                 280                 285             


Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala Ala 
    290                 295                 300                 


Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro Cys 
305                 310                 315                 320 


Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly Asp 
                325                 330                 335     


Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr Val 
            340                 345                 350         


Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu Cys 
        355                 360                 365             


Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu Trp 
    370                 375                 380                 


Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu Thr 
385                 390                 395                 400 


Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser Gly 
                405                 410                 415     


Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu Gly 
            420                 425                 430         


Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu Trp 
        435                 440                 445             


Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr Ile 
    450                 455                 460                 


His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala Ala 
465                 470                 475                 480 


Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Ala Ala 
                485                 490                 495     


Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly 
            500                 505                 510         


Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro 
        515                 520                 525             


Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln 
    530                 535                 540                 


Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu 
545                 550                 555                 560 


Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys 
                565                 570                 575     


Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro 
            580                 585                 590         


His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu 
        595                 600                 605             


Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu 
    610                 615                 620                 


Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe 
625                 630                 635                 640 


Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro 
                645                 650                 655     


Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser 
            660                 665                 670         


Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr 
        675                 680                 685             


Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly 
    690                 695                 700                 


Asp Gly Thr 
705         


<210>  349
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  349

Met Glu Ser Gln Pro Phe Leu Asn Met Lys Phe Glu Thr Asp Tyr Phe 
1               5                   10                  15      


Val Lys Val Val Pro Phe Pro Ser Ile Lys Asn Glu Ser Asn Tyr His 
            20                  25                  30          


Pro Phe Phe Phe Arg Thr Arg Ala Cys Asp Leu Leu Leu Gln Pro Asp 
        35                  40                  45              


Asn Leu Ala Cys Lys Pro Phe Trp Lys Pro Arg Asn Leu Asn Ile Ser 
    50                  55                  60                  


Gln His Gly Ser Asp Met Gln Val Ser Phe Asp His Ala Pro His Asn 
65                  70                  75                  80  


Phe Gly Phe Arg Phe Phe Tyr Leu His Tyr Lys Leu Lys His Glu Gly 
                85                  90                  95      


Pro Phe Lys Arg Lys Thr Cys Lys Gln Glu Gln Thr Thr Glu Thr Thr 
            100                 105                 110         


Ser Cys Leu Leu Gln Asn Val Ser Pro Gly Asp Tyr Ile Ile Glu Leu 
        115                 120                 125             


Val Asp Asp Thr Asn Thr Thr Arg Lys Val Met His Tyr Ala Leu Lys 
    130                 135                 140                 


Pro Val His Ser Pro Trp Ala Gly Pro Ile Arg Ala Val Ala Ile Thr 
145                 150                 155                 160 


Val Pro Leu Val Val Ile Ser Ala Phe Ala Thr Leu Phe Thr Val Met 
                165                 170                 175     


Cys Arg Lys Lys Gln Gln Glu Asn Ile Tyr Ser His Leu Asp Glu Glu 
            180                 185                 190         


Ser Ser Glu Ser Ser Thr Tyr Thr Ala Ala Leu Pro Arg Glu Arg Leu 
        195                 200                 205             


Arg Pro Arg Pro Lys Val Phe Leu Cys Tyr Ser Ser Lys Asp Gly Gln 
    210                 215                 220                 


Asn His Met Asn Val Val Gln Cys Phe Ala Tyr Phe Leu Gln Asp Phe 
225                 230                 235                 240 


Cys Gly Cys Glu Val Ala Leu Asp Leu Trp Glu Asp Phe Ser Leu Cys 
                245                 250                 255     


Arg Glu Gly Gln Arg Glu Trp Val Ile Gln Lys Ile His Glu Ser Gln 
            260                 265                 270         


Phe Ile Ile Val Val Cys Ser Lys Gly Met Lys Tyr Phe Val Asp Lys 
        275                 280                 285             


Lys Asn Tyr Lys His Lys Gly Gly Gly Arg Gly Ser Gly Lys Gly Glu 
    290                 295                 300                 


Leu Phe Leu Val Ala Val Ser Ala Ile Ala Glu Lys Leu Arg Gln Ala 
305                 310                 315                 320 


Lys Gln Ser Ser Ser Ala Ala Leu Ser Lys Phe Ile Ala Val Tyr Phe 
                325                 330                 335     


Asp Tyr Ser Cys Glu Gly Asp Val Pro Gly Ile Leu Asp Leu Ser Thr 
            340                 345                 350         


Lys Tyr Arg Leu Met Asp Asn Leu Pro Gln Leu Cys Ser His Leu His 
        355                 360                 365             


Ser Arg Asp His Gly Leu Gln Glu Pro Gly Gln His Thr Arg Gln Gly 
    370                 375                 380                 


Ser Arg Arg Asn Tyr Phe Arg Ser Lys Ser Gly Arg Ser Leu Tyr Val 
385                 390                 395                 400 


Ala Ile Cys Asn Met His Gln Phe Ile Asp Glu Glu Pro Asp Trp Phe 
                405                 410                 415     


Glu Lys Gln Phe Val Pro Phe His Pro Pro Pro Leu Arg Tyr Arg Glu 
            420                 425                 430         


Pro Val Leu Glu Lys Phe Asp Ser Gly Leu Val Leu Asn Asp Val Met 
        435                 440                 445             


Cys Lys Pro Gly Pro Glu Ser Asp Phe Cys Leu Lys Val Glu Ala Ala 
    450                 455                 460                 


Val Leu Gly Ala Thr Gly Pro Ala Asp Ser Gln His Glu Ser Gln His 
465                 470                 475                 480 


Gly Gly Leu Asp Gln Asp Gly Glu Ala Arg Pro Ala Leu Asp Gly Ser 
                485                 490                 495     


Ala Ala Leu Gln Pro Leu Leu His Thr Val Lys Ala Gly Ser Pro Ser 
            500                 505                 510         


Asp Met Pro Arg Asp Ser Gly Ile Tyr Asp Ser Ser Val Pro Ser Ser 
        515                 520                 525             


Glu Leu Ser Leu Pro Leu Met Glu Gly Leu Ser Thr Asp Gln Thr Glu 
    530                 535                 540                 


Thr Ser Ser Leu Thr Glu Ser Val Ser Ser Ser Ser Gly Leu Gly Glu 
545                 550                 555                 560 


Glu Glu Pro Pro Ala Leu Pro Ser Lys Leu Leu Ser Ser Gly Ser Cys 
                565                 570                 575     


Lys Ala Asp Leu Gly Cys Arg Ser Tyr Thr Asp Glu Leu His Ala Val 
            580                 585                 590         


Ala Pro Leu 
        595 


<210>  350
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  350

Met Gly Ser Ser Arg Leu Ala Ala Leu Leu Leu Pro Leu Leu Leu Ile 
1               5                   10                  15      


Val Ile Asp Leu Ser Asp Ser Ala Gly Ile Gly Phe Arg His Leu Pro 
            20                  25                  30          


His Trp Asn Thr Arg Cys Pro Leu Ala Ser His Thr Asp Asp Ser Phe 
        35                  40                  45              


Thr Gly Ser Ser Ala Tyr Ile Pro Cys Arg Thr Trp Trp Ala Leu Phe 
    50                  55                  60                  


Ser Thr Lys Pro Trp Cys Val Arg Val Trp His Cys Ser Arg Cys Leu 
65                  70                  75                  80  


Cys Gln His Leu Leu Ser Gly Gly Ser Gly Leu Gln Arg Gly Leu Phe 
                85                  90                  95      


His Leu Leu Val Gln Lys Ser Lys Lys Ser Ser Thr Phe Lys Phe Tyr 
            100                 105                 110         


Arg Arg His Lys Met Pro Ala Pro Ala Gln Arg Lys Leu Leu Pro Arg 
        115                 120                 125             


Arg His Leu Ser Glu Lys Ser His His Ile Ser Ile Pro Ser Pro Asp 
    130                 135                 140                 


Ile Ser His Lys Gly Leu Arg Ser Lys Arg Thr Gln Pro Ser Asp Pro 
145                 150                 155                 160 


Glu Thr Trp Glu Ser Leu Pro Arg Leu Asp Ser Gln Arg His Gly Gly 
                165                 170                 175     


Pro Glu Phe Ser Phe Asp Leu Leu Pro Glu Ala Arg Ala Ile Arg Val 
            180                 185                 190         


Thr Ile Ser Ser Gly Pro Glu Val Ser Val Arg Leu Cys His Gln Trp 
        195                 200                 205             


Ala Leu Glu Cys Glu Glu Leu Ser Ser Pro Tyr Asp Val Gln Lys Ile 
    210                 215                 220                 


Val Ser Gly Gly His Thr Val Glu Leu Pro Tyr Glu Phe Leu Leu Pro 
225                 230                 235                 240 


Cys Leu Cys Ile Glu Ala Ser Tyr Leu Gln Glu Asp Thr Val Arg Arg 
                245                 250                 255     


Lys Lys Cys Pro Phe Gln Ser Trp Pro Glu Ala Tyr Gly Ser Asp Phe 
            260                 265                 270         


Trp Lys Ser Val His Phe Thr Asp Tyr Ser Gln His Thr Gln Met Val 
        275                 280                 285             


Met Ala Leu Thr Leu Arg Cys Pro Leu Lys Leu Glu Ala Ala Leu Cys 
    290                 295                 300                 


Gln Arg His Asp Trp His Thr Leu Cys Lys Asp Leu Pro Asn Ala Thr 
305                 310                 315                 320 


Ala Arg Glu Ser Asp Gly Trp Tyr Val Leu Glu Lys Val Asp Leu His 
                325                 330                 335     


Pro Gln Leu Cys Phe Lys Phe Ser Phe Gly Asn Ser Ser His Val Glu 
            340                 345                 350         


Cys Pro His Gln Thr Gly Ser Leu Thr Ser Trp Asn Val Ser Met Asp 
        355                 360                 365             


Thr Gln Ala Gln Gln Leu Ile Leu His Phe Ser Ser Arg Met His Ala 
    370                 375                 380                 


Thr Phe Ser Ala Ala Trp Ser Leu Pro Gly Leu Gly Gln Asp Thr Leu 
385                 390                 395                 400 


Val Pro Pro Val Tyr Thr Val Ser Gln Ala Arg Gly Ser Ser Pro Val 
                405                 410                 415     


Ser Leu Asp Leu Ile Ile Pro Phe Leu Arg Pro Gly Cys Cys Val Leu 
            420                 425                 430         


Leu His Ala Ser Leu Ser Ser Pro Gly Gly Glu Asp Ala Trp Leu Ile 
        435                 440                 445             


Gly Val Gly Gly Ser Val Pro Ser Gly Val Ala Val Arg Cys Pro Val 
    450                 455                 460                 


Cys Leu Glu Ala Pro Leu Val Ser Gly Cys Leu Leu Gln Thr Pro Gly 
465                 470                 475                 480 


Ala Leu Asp Pro Gly Thr Ala Gly Pro Pro His Pro Thr Gly Cys Cys 
                485                 490                 495     


Ser Gly Pro His Leu Pro Ala Pro Thr Val Arg Pro Gly Pro Ser Ala 
            500                 505                 510         


Ala Ser Ala Pro Pro Ala Arg Gly Gly Leu Gly Gly Ala Ala Ala Pro 
        515                 520                 525             


Gly Gly Ser Ala Gly 
    530             


<210>  351
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  351

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Lys Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Gly Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  352
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  352

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln 
    290                 295     


<210>  353
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser Lys Ile Tyr Cys 
1               5                   10                  15      


Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu Glu Trp Phe Lys 
            20                  25                  30          


Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala His Lys Ser Phe 
        35                  40                  45              


Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly Asp Tyr Thr Cys 
    50                  55                  60                  


Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser Val Thr Ala Thr 
65                  70                  75                  80  


Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser Leu Phe Pro Val 
                85                  90                  95      


Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val Glu Ile Gly Lys 
            100                 105                 110         


Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys Gly Thr Gln Phe 
        115                 120                 125             


Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys Ile Thr Asp Phe 
    130                 135                 140                 


Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn Gln Ser Phe Ser 
145                 150                 155                 160 


Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile Ala Asp Val Lys 
                165                 170                 175     


Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala Leu Asn Leu His 
            180                 185                 190         


Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys Asn Pro Ser Lys 
        195                 200                 205             


Glu Cys Phe 
    210     


<210>  354
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  354

Met Trp Ser Leu Leu Leu Cys Gly Leu Ser Ile Ala Leu Pro Leu Ser 
1               5                   10                  15      


Val Thr Ala Asp Gly Cys Lys Asp Ile Phe Met Lys Asn Glu Ile Leu 
            20                  25                  30          


Ser Ala Ser Gln Pro Phe Ala Phe Asn Cys Thr Phe Pro Pro Ile Thr 
        35                  40                  45              


Ser Gly Glu Val Ser Val Thr Trp Tyr Lys Asn Ser Ser Lys Ile Pro 
    50                  55                  60                  


Val Ser Lys Ile Ile Gln Ser Arg Ile His Gln Asp Glu Thr Trp Ile 
65                  70                  75                  80  


Leu Phe Leu Pro Met Glu Trp Gly Asp Ser Gly Val Tyr Gln Cys Val 
                85                  90                  95      


Ile Lys Gly Arg Asp Ser Cys His Arg Ile His Val Asn Leu Thr Val 
            100                 105                 110         


Phe Glu Lys His Trp Cys Asp Thr Ser Ile Gly Gly Leu Pro Asn Leu 
        115                 120                 125             


Ser Asp Glu Tyr Lys Gln Ile Leu His Leu Gly Lys Asp Asp Ser Leu 
    130                 135                 140                 


Thr Cys His Leu His Phe Pro Lys Ser Cys Val Leu Gly Pro Ile Lys 
145                 150                 155                 160 


Trp Tyr Lys Asp Cys Asn Glu Ile Lys Gly Glu Arg Phe Thr Val Leu 
                165                 170                 175     


Glu Thr Arg Leu Leu Val Ser Asn Val Ser Ala Glu Asp Arg Gly Asn 
            180                 185                 190         


Tyr Ala Cys Gln Ala Ile Leu Thr His Ser Gly Lys Gln Tyr Glu Val 
        195                 200                 205             


Leu Asn Gly Ile Thr Val Ser Ile Thr Glu Arg Ala Gly Tyr Gly Gly 
    210                 215                 220                 


Ser Val Pro Lys Ile Ile Tyr Pro Lys Asn His Ser Ile Glu Val Gln 
225                 230                 235                 240 


Leu Gly Thr Thr Leu Ile Val Asp Cys Asn Val Thr Asp Thr Lys Asp 
                245                 250                 255     


Asn Thr Asn Leu Arg Cys Trp Arg Val Asn Asn Thr Leu Val Asp Asp 
            260                 265                 270         


Tyr Tyr Asp Glu Ser Lys Arg Ile Arg Glu Gly Val Glu Thr His Val 
        275                 280                 285             


Ser Phe Arg Glu His Asn Leu Tyr Thr Val Asn Ile Thr Phe Leu Glu 
    290                 295                 300                 


Val Lys Met Glu Asp Tyr Gly Leu Pro Phe Met Cys His Ala Gly Val 
305                 310                 315                 320 


Ser Thr Ala Tyr Ile Ile Leu Gln Leu Pro Ala Pro Asp Phe Arg Ala 
                325                 330                 335     


Tyr Leu Ile Gly Gly Leu Ile Ala Leu Val Ala Val Ala Val Ser Val 
            340                 345                 350         


Val Tyr Ile Tyr Asn Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Ser Ala Phe His Ser Thr Glu Thr Ile Val Asp Gly Lys Leu Tyr Asp 
    370                 375                 380                 


Ala Tyr Val Leu Tyr Pro Lys Pro His Lys Glu Ser Gln Arg His Ala 
385                 390                 395                 400 


Val Asp Ala Leu Val Leu Asn Ile Leu Pro Glu Val Leu Glu Arg Gln 
                405                 410                 415     


Cys Gly Tyr Lys Leu Phe Ile Phe Gly Arg Asp Glu Phe Pro Gly Gln 
            420                 425                 430         


Ala Val Ala Asn Val Ile Asp Glu Asn Val Lys Leu Cys Arg Arg Leu 
        435                 440                 445             


Ile Val Ile Val Val Pro Glu Ser Leu Gly Phe Gly Leu Leu Lys Asn 
    450                 455                 460                 


Leu Ser Glu Glu Gln Ile Ala Val Tyr Ser Ala Leu Ile Gln Asp Gly 
465                 470                 475                 480 


Met Lys Val Ile Leu Ile Glu Leu Glu Lys Ile Glu Asp Tyr Thr Val 
                485                 490                 495     


Met Pro Glu Ser Ile Gln Tyr Ile Lys Gln Lys His Gly Ala Ile Arg 
            500                 505                 510         


Trp His Gly Asp Phe Thr Glu Gln Ser Gln Cys Met Lys Thr Lys Phe 
        515                 520                 525             


Trp Lys Thr Val Arg Tyr His Met Pro Pro Arg Arg Cys Arg Pro Phe 
    530                 535                 540                 


Pro Pro Val Gln Leu Leu Gln His Thr Pro Cys Tyr Arg Thr Ala Gly 
545                 550                 555                 560 


Pro Glu Leu Gly Ser Arg Arg Lys Lys Cys Thr Leu Thr Thr Gly 
                565                 570                 575 


<210>  355
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Asn Cys Lys Lys Leu Leu Leu Glu Asn Asn Lys Asn Pro Thr Ile 
1               5                   10                  15      


Lys Lys Asn Ala Glu Phe Glu Asp Gln Gly Tyr Tyr Ser Cys Val His 
            20                  25                  30          


Phe Leu His His Asn Gly Lys Leu Phe Asn Ile Thr Lys Thr Phe Asn 
        35                  40                  45              


Ile Thr Ile Val Glu Asp Arg Ser Asn Ile Val Pro Val Leu Leu Gly 
    50                  55                  60                  


Pro Lys Leu Asn His Val Ala Val Glu Leu Gly Lys Asn Val Arg Leu 
65                  70                  75                  80  


Asn Cys Ser Ala Leu Leu Asn Glu Glu Asp Val Ile Tyr Trp Met Phe 
                85                  90                  95      


Gly Glu Glu Asn Gly Ser Asp Pro Asn Ile His Glu Glu Lys Glu Met 
            100                 105                 110         


Arg Ile Met Thr Pro Glu Gly Lys Trp His Ala Ser Lys Val Leu Arg 
        115                 120                 125             


Ile Glu Asn Ile Gly Glu Ser Asn Leu Asn Val Leu Tyr Asn Cys Thr 
    130                 135                 140                 


Val Ala Ser Thr Gly Gly Thr Asp Thr Lys Ser Phe Ile Leu Val Arg 
145                 150                 155                 160 


Lys Asp Met Ala Asp Ile Pro Gly His Val Phe Thr Arg Gly Met Ile 
                165                 170                 175     


Ile Ala Val Leu Ile Leu Val Ala Val Val Cys Leu Val Thr Val Cys 
            180                 185                 190         


Val Ile Tyr Arg Val Asp Leu Val Leu Phe Tyr Arg His Leu Thr Arg 
        195                 200                 205             


Arg Asp Glu Thr Leu Thr Asp Gly Lys Thr Tyr Asp Ala Phe Val Ser 
    210                 215                 220                 


Tyr Leu Lys Glu Cys Arg Pro Glu Asn Gly Glu Glu His Thr Phe Ala 
225                 230                 235                 240 


Val Glu Ile Leu Pro Arg Val Leu Glu Lys His Phe Gly Tyr Lys Leu 
                245                 250                 255     


Cys Ile Phe Glu Arg Asp Val Val Pro Gly Gly Ala Val Val Asp Glu 
            260                 265                 270         


Ile His Ser Leu Ile Glu Lys Ser Arg Arg Leu Ile Ile Val Leu Ser 
        275                 280                 285             


Lys Ser Tyr Met Ser Asn Glu Val Arg Tyr Glu Leu Glu Ser Gly Leu 
    290                 295                 300                 


His Glu Ala Leu Val Glu Arg Lys Ile Lys Ile Ile Leu Ile Glu Phe 
305                 310                 315                 320 


Thr Pro Val Thr Asp Phe Thr Phe Leu Pro Gln Ser Leu Lys Leu Leu 
                325                 330                 335     


Lys Ser His Arg Val Leu Lys Trp Lys Ala Asp Lys Ser Leu Ser Tyr 
            340                 345                 350         


Asn Ser Arg Phe Trp Lys Asn Leu Leu Tyr Leu Met Pro Ala Lys Thr 
        355                 360                 365             


Val Lys Pro Gly Arg Asp Glu Pro Glu Val Leu Pro Val Leu Ser Glu 
    370                 375                 380                 


Ser 
385 


<210>  356
<211>  570
<212>  PRT
<213>  Homo sapiens

<400>  356

Met Thr Leu Leu Trp Cys Val Val Ser Leu Tyr Phe Tyr Gly Ile Leu 
1               5                   10                  15      


Gln Ser Asp Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          


Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              


Leu Phe Glu His Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala 
    50                  55                  60                  


Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  


Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      


Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             


Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu 
    130                 135                 140                 


Pro Val His Lys Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys 
145                 150                 155                 160 


Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr 
                165                 170                 175     


Trp Tyr Met Gly Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro 
            180                 185                 190         


Glu Gly Met Asn Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly 
        195                 200                 205             


Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His 
    210                 215                 220                 


Leu Thr Arg Thr Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala 
225                 230                 235                 240 


Val Pro Pro Val Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys 
                245                 250                 255     


Glu Pro Gly Glu Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe 
            260                 265                 270         


Leu Met Asp Ser Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             


Pro Asp Asp Ile Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His 
    290                 295                 300                 


Ser Arg Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 


Val Thr Ser Glu Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser 
                325                 330                 335     


Ala Lys Gly Glu Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro 
            340                 345                 350         


Ala Pro Arg Tyr Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val 
        355                 360                 365             


Leu Leu Val Val Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu 
    370                 375                 380                 


Met Val Leu Phe Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu 
385                 390                 395                 400 


Asp Gly Lys Glu Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu 
                405                 410                 415     


Glu Glu Glu Phe Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu 
            420                 425                 430         


Phe Gly Tyr Lys Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly 
        435                 440                 445             


Ile Val Thr Asp Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu 
    450                 455                 460                 


Leu Val Val Leu Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu 
465                 470                 475                 480 


Leu Glu Leu Lys Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile 
                485                 490                 495     


Asn Val Ile Leu Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys 
            500                 505                 510         


Glu Leu Lys Arg Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly 
        515                 520                 525             


Glu Lys Ser Lys Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val 
    530                 535                 540                 


Ala Met Pro Val Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln 
545                 550                 555                 560 


Gly Leu Ser Tyr Ser Ser Leu Lys Asn Val 
                565                 570 


<210>  357
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  357

Met Leu Cys Leu Gly Trp Ile Phe Leu Trp Leu Val Ala Gly Glu Arg 
1               5                   10                  15      


Ile Lys Gly Phe Asn Ile Ser Gly Cys Ser Thr Lys Lys Leu Leu Trp 
            20                  25                  30          


Thr Tyr Ser Thr Arg Ser Glu Glu Glu Phe Val Leu Phe Cys Asp Leu 
        35                  40                  45              


Pro Glu Pro Gln Lys Ser His Phe Cys His Arg Asn Arg Leu Ser Pro 
    50                  55                  60                  


Lys Gln Val Pro Glu His Leu Pro Phe Met Gly Ser Asn Asp Leu Ser 
65                  70                  75                  80  


Asp Val Gln Trp Tyr Gln Gln Pro Ser Asn Gly Asp Pro Leu Glu Asp 
                85                  90                  95      


Ile Arg Lys Ser Tyr Pro His Ile Ile Gln Asp Lys Cys Thr Leu His 
            100                 105                 110         


Phe Leu Thr Pro Gly Val Asn Asn Ser Gly Ser Tyr Ile Cys Arg Pro 
        115                 120                 125             


Lys Met Ile Lys Ser Pro Tyr Asp Val Ala Cys Cys Val Lys Met Ile 
    130                 135                 140                 


Leu Glu Val Lys Pro Gln Thr Asn Ala Ser Cys Glu Tyr Ser Ala Ser 
145                 150                 155                 160 


His Lys Gln Asp Leu Leu Leu Gly Ser Thr Gly Ser Ile Ser Cys Pro 
                165                 170                 175     


Ser Leu Ser Cys Gln Ser Asp Ala Gln Ser Pro Ala Val Thr Trp Tyr 
            180                 185                 190         


Lys Asn Gly Lys Leu Leu Ser Val Glu Arg Ser Asn Arg Ile Val Val 
        195                 200                 205             


Asp Glu Val Tyr Asp Tyr His Gln Gly Thr Tyr Val Cys Asp Tyr Thr 
    210                 215                 220                 


Gln Ser Asp Thr Val Ser Ser Trp Thr Val Arg Ala Val Val Gln Val 
225                 230                 235                 240 


Arg Thr Ile Val Gly Asp Thr Lys Leu Lys Pro Asp Ile Leu Asp Pro 
                245                 250                 255     


Val Glu Asp Thr Leu Glu Val Glu Leu Gly Lys Pro Leu Thr Ile Ser 
            260                 265                 270         


Cys Lys Ala Arg Phe Gly Phe Glu Arg Val Phe Asn Pro Val Ile Lys 
        275                 280                 285             


Trp Tyr Ile Lys Asp Ser Asp Leu Glu Trp Glu Val Ser Val Pro Glu 
    290                 295                 300                 


Ala Lys Ser Ile Lys Ser Thr Leu Lys Asp Glu Ile Ile Glu Arg Asn 
305                 310                 315                 320 


Ile Ile Leu Glu Lys Val Thr Gln Arg Asp Leu Arg Arg Lys Phe Val 
                325                 330                 335     


Cys Phe Val Gln Asn Ser Ile Gly Asn Thr Thr Gln Ser Val Gln Leu 
            340                 345                 350         


Lys Glu Lys Arg Gly Val Val Leu Leu Tyr Ile Leu Leu Gly Thr Ile 
        355                 360                 365             


Gly Thr Leu Val Ala Val Leu Ala Ala Ser Ala Leu Leu Tyr Arg His 
    370                 375                 380                 


Trp Ile Glu Ile Val Leu Leu Tyr Arg Thr Tyr Gln Ser Lys Asp Gln 
385                 390                 395                 400 


Thr Leu Gly Asp Lys Lys Asp Phe Asp Ala Phe Val Ser Tyr Ala Lys 
                405                 410                 415     


Trp Ser Ser Phe Pro Ser Glu Ala Thr Ser Ser Leu Ser Glu Glu His 
            420                 425                 430         


Leu Ala Leu Ser Leu Phe Pro Asp Val Leu Glu Asn Lys Tyr Gly Tyr 
        435                 440                 445             


Ser Leu Cys Leu Leu Glu Arg Asp Val Ala Pro Gly Gly Val Tyr Ala 
    450                 455                 460                 


Glu Asp Ile Val Ser Ile Ile Lys Arg Ser Arg Arg Gly Ile Phe Ile 
465                 470                 475                 480 


Leu Ser Pro Asn Tyr Val Asn Gly Pro Ser Ile Phe Glu Leu Gln Ala 
                485                 490                 495     


Ala Val Asn Leu Ala Leu Asp Asp Gln Thr Leu Lys Leu Ile Leu Ile 
            500                 505                 510         


Lys Phe Cys Tyr Phe Gln Glu Pro Glu Ser Leu Pro His Leu Val Lys 
        515                 520                 525             


Lys Ala Leu Arg Val Leu Pro Thr Val Thr Trp Arg Gly Leu Lys Ser 
    530                 535                 540                 


Val Pro Pro Asn Ser Arg Phe Trp Ala Lys Met Arg Tyr His Met Pro 
545                 550                 555                 560 


Val Lys Asn Ser Gln Gly Phe Thr Trp Asn Gln Leu Arg Ile Thr Ser 
                565                 570                 575     


Arg Ile Phe Gln Trp Lys Gly Leu Ser Arg Thr Glu Thr Thr Gly Arg 
            580                 585                 590         


Ser Ser Gln Pro Lys Glu Trp 
        595                 


<210>  358
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  359
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  359

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  360
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  360

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  361
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  361

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  362
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  362

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  363
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  364
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  364

Met Glu Ala Thr Gly Ile Ser Leu Ala Ser Gln Leu Lys Val Pro Pro 
1               5                   10                  15      


Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys Glu Tyr Tyr 
            20                  25                  30          


Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro Gly Thr Tyr 
        35                  40                  45              


Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys Ala Thr Cys 
    50                  55                  60                  


Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr Ile Cys Gln 
65                  70                  75                  80  


Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu Ile Ala Pro 
                85                  90                  95      


Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro Gly Met Phe 
            100                 105                 110         


Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu Leu Ser Asp 
        115                 120                 125             


Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val Gly Lys Gly 
    130                 135                 140                 


Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln Asn Thr Ser 
145                 150                 155                 160 


Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu Asn Gln Gly 
                165                 170                 175     


Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr Thr Cys Lys 
            180                 185                 190         


Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr Met Leu Met 
        195                 200                 205             


Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val 
    210                 215                 220                 


Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly 
225                 230                 235                 240 


Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala 
                245                 250                 255     


Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val 
            260                 265                 270         


Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly 
        275                 280                 285             


Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser 
    290                 295                 300                 


Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser 
305                 310                 315                 320 


Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met 
                325                 330                 335     


Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly 
            340                 345                 350         


Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro 
        355                 360                 365             


Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His 
    370                 375                 380                 


Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly 
385                 390                 395                 400 


Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp 
                405                 410                 415     


<210>  365
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  366
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  366

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  367
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  367

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Lys Glu Val Gln Lys Thr Cys Arg Lys His Arg Lys Glu Asn Gln Gly 
        195                 200                 205             


Ser His Glu Ser Pro Thr Leu Asn Pro Glu Thr Val Ala Ile Asn Leu 
    210                 215                 220                 


Ser Asp Val Asp Leu Ser Lys Tyr Ile Thr Thr Ile Ala Gly Val Met 
225                 230                 235                 240 


Thr Leu Ser Gln Val Lys Gly Phe Val Arg Lys Asn Gly Val Asn Glu 
                245                 250                 255     


Ala Lys Ile Asp Glu Ile Lys Asn Asp Asn Val Gln Asp Thr Ala Glu 
            260                 265                 270         


Gln Lys Val Gln Leu Leu Arg Asn Trp His Gln Leu His Gly Lys Lys 
        275                 280                 285             


Glu Ala Tyr Asp Thr Leu Ile Lys Asp Leu Lys Lys Ala Asn Leu Cys 
    290                 295                 300                 


Thr Leu Ala Glu Lys Ile Gln Thr Ile Ile Leu Lys Asp Ile Thr Ser 
305                 310                 315                 320 


Asp Ser Glu Asn Ser Asn Phe Arg Asn Glu Ile Gln Ser Leu Val 
                325                 330                 335 


<210>  368
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  368

Met Arg Ala Leu Glu Gly Pro Gly Leu Ser Leu Leu Cys Leu Val Leu 
1               5                   10                  15      


Ala Leu Pro Ala Leu Leu Pro Val Pro Ala Val Arg Gly Val Ala Glu 
            20                  25                  30          


Thr Pro Thr Tyr Pro Trp Arg Asp Ala Glu Thr Gly Glu Arg Leu Val 
        35                  40                  45              


Cys Ala Gln Cys Pro Pro Gly Thr Phe Val Gln Arg Pro Cys Arg Arg 
    50                  55                  60                  


Asp Ser Pro Thr Thr Cys Gly Pro Cys Pro Pro Arg His Tyr Thr Gln 
65                  70                  75                  80  


Phe Trp Asn Tyr Leu Glu Arg Cys Arg Tyr Cys Asn Val Leu Cys Gly 
                85                  90                  95      


Glu Arg Glu Glu Glu Ala Arg Ala Cys His Ala Thr His Asn Arg Ala 
            100                 105                 110         


Cys Arg Cys Arg Thr Gly Phe Phe Ala His Ala Gly Phe Cys Leu Glu 
        115                 120                 125             


His Ala Ser Cys Pro Pro Gly Ala Gly Val Ile Ala Pro Gly Thr Pro 
    130                 135                 140                 


Ser Gln Asn Thr Gln Cys Gln Pro Cys Pro Pro Gly Thr Phe Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Ser Ser Glu Gln Cys Gln Pro His Arg Asn Cys Thr Ala 
                165                 170                 175     


Leu Gly Leu Ala Leu Asn Val Pro Gly Ser Ser Ser His Asp Thr Leu 
            180                 185                 190         


Cys Thr Ser Cys Thr Gly Phe Pro Leu Ser Thr Arg Val Pro Gly Ala 
        195                 200                 205             


Glu Glu Cys Glu Arg Ala Val Ile Asp Phe Val Ala Phe Gln Asp Ile 
    210                 215                 220                 


Ser Ile Lys Arg Leu Gln Arg Leu Leu Gln Ala Leu Glu Ala Pro Glu 
225                 230                 235                 240 


Gly Trp Gly Pro Thr Pro Arg Ala Gly Arg Ala Ala Leu Gln Leu Lys 
                245                 250                 255     


Leu Arg Arg Arg Leu Thr Glu Leu Leu Gly Ala Gln Asp Gly Ala Leu 
            260                 265                 270         


Leu Val Arg Leu Leu Gln Ala Leu Arg Val Ala Arg Met Pro Gly Leu 
        275                 280                 285             


Glu Arg Ser Val Arg Glu Arg Phe Leu Pro Val His 
    290                 295                 300 


<210>  369
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  369

Met Ala Arg Pro His Pro Trp Trp Leu Cys Val Leu Gly Thr Leu Val 
1               5                   10                  15      


Gly Leu Ser Ala Thr Pro Ala Pro Lys Ser Cys Pro Glu Arg His Tyr 
            20                  25                  30          


Trp Ala Gln Gly Lys Leu Cys Cys Gln Met Cys Glu Pro Gly Thr Phe 
        35                  40                  45              


Leu Val Lys Asp Cys Asp Gln His Arg Lys Ala Ala Gln Cys Asp Pro 
    50                  55                  60                  


Cys Ile Pro Gly Val Ser Phe Ser Pro Asp His His Thr Arg Pro His 
65                  70                  75                  80  


Cys Glu Ser Cys Arg His Cys Asn Ser Gly Leu Leu Val Arg Asn Cys 
                85                  90                  95      


Thr Ile Thr Ala Asn Ala Glu Cys Ala Cys Arg Asn Gly Trp Gln Cys 
            100                 105                 110         


Arg Asp Lys Glu Cys Thr Glu Cys Asp Pro Leu Pro Asn Pro Ser Leu 
        115                 120                 125             


Thr Ala Arg Ser Ser Gln Ala Leu Ser Pro His Pro Gln Pro Thr His 
    130                 135                 140                 


Leu Pro Tyr Val Ser Glu Met Leu Glu Ala Arg Thr Ala Gly His Met 
145                 150                 155                 160 


Gln Thr Leu Ala Asp Phe Arg Gln Leu Pro Ala Arg Thr Leu Ser Thr 
                165                 170                 175     


His Trp Pro Pro Gln Arg Ser Leu Cys Ser Ser Asp Phe Ile Arg Ile 
            180                 185                 190         


Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala 
        195                 200                 205             


Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser 
    210                 215                 220                 


Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu 
225                 230                 235                 240 


Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro 
                245                 250                 255     


Ala Cys Ser Pro 
            260 


<210>  370
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  370

Met Arg Val Leu Leu Ala Ala Leu Gly Leu Leu Phe Leu Gly Ala Leu 
1               5                   10                  15      


Arg Ala Phe Pro Gln Asp Arg Pro Phe Glu Asp Thr Cys His Gly Asn 
            20                  25                  30          


Pro Ser His Tyr Tyr Asp Lys Ala Val Arg Arg Cys Cys Tyr Arg Cys 
        35                  40                  45              


Pro Met Gly Leu Phe Pro Thr Gln Gln Cys Pro Gln Arg Pro Thr Asp 
    50                  55                  60                  


Cys Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Asp Arg 
65                  70                  75                  80  


Cys Thr Ala Cys Val Thr Cys Ser Arg Asp Asp Leu Val Glu Lys Thr 
                85                  90                  95      


Pro Cys Ala Trp Asn Ser Ser Arg Val Cys Glu Cys Arg Pro Gly Met 
            100                 105                 110         


Phe Cys Ser Thr Ser Ala Val Asn Ser Cys Ala Arg Cys Phe Phe His 
        115                 120                 125             


Ser Val Cys Pro Ala Gly Met Ile Val Lys Phe Pro Gly Thr Ala Gln 
    130                 135                 140                 


Lys Asn Thr Val Cys Glu Pro Ala Ser Pro Gly Val Ser Pro Ala Cys 
145                 150                 155                 160 


Ala Ser Pro Glu Asn Cys Lys Glu Pro Ser Ser Gly Thr Ile Pro Gln 
                165                 170                 175     


Ala Lys Pro Thr Pro Val Ser Pro Ala Thr Ser Ser Ala Ser Thr Met 
            180                 185                 190         


Pro Val Arg Gly Gly Thr Arg Leu Ala Gln Glu Ala Ala Ser Lys Leu 
        195                 200                 205             


Thr Arg Ala Pro Asp Ser Pro Ser Ser Val Gly Arg Pro Ser Ser Asp 
    210                 215                 220                 


Pro Gly Leu Ser Pro Thr Gln Pro Cys Pro Glu Gly Ser Gly Asp Cys 
225                 230                 235                 240 


Arg Lys Gln Cys Glu Pro Asp Tyr Tyr Leu Asp Glu Ala Gly Arg Cys 
                245                 250                 255     


Thr Ala Cys Val Ser Cys Ser Arg Asp Asp Leu Val Glu Lys Thr Pro 
            260                 265                 270         


Cys Ala Trp Asn Ser Ser Arg Thr Cys Glu Cys Arg Pro Gly Met Ile 
        275                 280                 285             


Cys Ala Thr Ser Ala Thr Asn Ser Cys Ala Arg Cys Val Pro Tyr Pro 
    290                 295                 300                 


Ile Cys Ala Ala Glu Thr Val Thr Lys Pro Gln Asp Met Ala Glu Lys 
305                 310                 315                 320 


Asp Thr Thr Phe Glu Ala Pro Pro Leu Gly Thr Gln Pro Asp Cys Asn 
                325                 330                 335     


Pro Thr Pro Glu Asn Gly Glu Ala Pro Ala Ser Thr Ser Pro Thr Gln 
            340                 345                 350         


Ser Leu Leu Val Asp Ser Gln Ala Ser Lys Thr Leu Pro Ile Pro Thr 
        355                 360                 365             


Ser Ala Pro Val Ala Leu Ser Ser Thr Gly Lys Pro Val Leu Asp Ala 
    370                 375                 380                 


Gly Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
385                 390                 395                 400 


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
                405                 410                 415     


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
            420                 425                 430         


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
        435                 440                 445             


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
    450                 455                 460                 


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
465                 470                 475                 480 


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
                485                 490                 495     


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
            500                 505                 510         


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
        515                 520                 525             


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
    530                 535                 540                 


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
545                 550                 555                 560 


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
                565                 570                 575     


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
            580                 585                 590         


Ser Gly Lys 
        595 


<210>  371
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  371

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  372
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  372

Met Ala Pro Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val 
1               5                   10                  15      


Thr Pro Asn Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala 
            20                  25                  30          


Thr Pro Ser Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg 
        35                  40                  45              


Gly Gly Gly Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro 
    50                  55                  60                  


Ser Ala Arg Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg 
65                  70                  75                  80  


Glu Ala Ser Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val 
                85                  90                  95      


Val Gly Val Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys 
            100                 105                 110         


Leu His Asp Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu 
        115                 120                 125             


Gly Glu Leu Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala 
    130                 135                 140                 


Cys Asn Arg Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn 
145                 150                 155                 160 


Leu Phe Ala Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu 
                165                 170                 175     


Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro 
            180                 185                 190         


Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser 
        195                 200                 205             


Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp 
    210                 215                 220                 


Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile 
225                 230                 235                 240 


Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala 
                245                 250                 255     


Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro 
            260                 265                 270         


Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp 
    290                 295                 300                 


Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro 
305                 310                 315                 320 


Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys 
                325                 330                 335     


Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu 
            340                 345                 350         


Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe 
        355                 360                 365             


Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met 
    370                 375                 380                 


Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly 
385                 390                 395                 400 


Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val 
                405                 410                 415     


Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu 
            420                 425                 430         


Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu 
        435                 440                 445             


Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala 
    450                 455                 460                 


Val Ser Leu Glu 
465             


<210>  373
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  374
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  374

Met Ala Arg Ile Pro Lys Thr Leu Lys Phe Val Val Val Ile Val Ala 
1               5                   10                  15      


Val Leu Leu Pro Val Leu Ala Tyr Ser Ala Thr Thr Ala Arg Gln Glu 
            20                  25                  30          


Glu Val Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg His Ser Phe 
        35                  40                  45              


Lys Gly Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu His Thr Gly 
    50                  55                  60                  


Ala Cys Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Asn Ala Ser Asn 
65                  70                  75                  80  


Asn Glu Pro Ser Cys Phe Pro Cys Thr Val Cys Lys Ser Asp Gln Lys 
                85                  90                  95      


His Lys Ser Ser Cys Thr Met Thr Arg Asp Thr Val Cys Gln Cys Lys 
            100                 105                 110         


Glu Gly Thr Phe Arg Asn Glu Asn Ser Pro Glu Met Cys Arg Lys Cys 
        115                 120                 125             


Ser Arg Cys Pro Ser Gly Glu Val Gln Val Ser Asn Cys Thr Ser Trp 
    130                 135                 140                 


Asp Asp Ile Gln Cys Val Glu Glu Phe Gly Ala Asn Ala Thr Val Glu 
145                 150                 155                 160 


Thr Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala 
                165                 170                 175     


Pro Ala Ala Glu Glu Thr Met Asn Thr Ser Pro Gly Thr Pro Ala Pro 
            180                 185                 190         


Ala Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala 
        195                 200                 205             


Ala Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Pro Ala Ala 
    210                 215                 220                 


Glu Glu Thr Met Thr Thr Ser Pro Gly Thr Pro Ala Ser Ser His Tyr 
225                 230                 235                 240 


Leu Ser Cys Thr Ile Val Gly Ile Ile Val Leu Ile Val Leu Leu Ile 
                245                 250                 255     


Val Phe Val 
            


<210>  375
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Gly Leu Trp Gly Gln Ser Val Pro Thr Ala Ser Ser Ala Arg Ala 
1               5                   10                  15      


Gly Arg Tyr Pro Gly Ala Arg Thr Ala Ser Gly Thr Arg Pro Trp Leu 
            20                  25                  30          


Leu Asp Pro Lys Ile Leu Lys Phe Val Val Phe Ile Val Ala Val Leu 
        35                  40                  45              


Leu Pro Val Arg Val Asp Ser Ala Thr Ile Pro Arg Gln Asp Glu Val 
    50                  55                  60                  


Pro Gln Gln Thr Val Ala Pro Gln Gln Gln Arg Arg Ser Leu Lys Glu 
65                  70                  75                  80  


Glu Glu Cys Pro Ala Gly Ser His Arg Ser Glu Tyr Thr Gly Ala Cys 
                85                  90                  95      


Asn Pro Cys Thr Glu Gly Val Asp Tyr Thr Ile Ala Ser Asn Asn Leu 
            100                 105                 110         


Pro Ser Cys Leu Leu Cys Thr Val Cys Lys Ser Gly Gln Thr Asn Lys 
        115                 120                 125             


Ser Ser Cys Thr Thr Thr Arg Asp Thr Val Cys Gln Cys Glu Lys Gly 
    130                 135                 140                 


Ser Phe Gln Asp Lys Asn Ser Pro Glu Met Cys Arg Thr Cys Arg Thr 
145                 150                 155                 160 


Gly Cys Pro Arg Gly Met Val Lys Val Ser Asn Cys Thr Pro Arg Ser 
                165                 170                 175     


Asp Ile Lys Cys Lys Asn Glu Ser Ala Ala Ser Ser Thr Gly Lys Thr 
            180                 185                 190         


Pro Ala Ala Glu Glu Thr Val Thr Thr Ile Leu Gly Met Leu Ala Ser 
        195                 200                 205             


Pro Tyr His Tyr Leu Ile Ile Ile Val Val Leu Val Ile Ile Leu Ala 
    210                 215                 220                 


Val Val Val Val Gly Phe Ser Cys Arg Lys Lys Phe Ile Ser Tyr Leu 
225                 230                 235                 240 


Lys Gly Ile Cys Ser Gly Gly Gly Gly Gly Pro Glu Arg Val His Arg 
                245                 250                 255     


Val Leu Phe Arg Arg Arg Ser Cys Pro Ser Arg Val Pro Gly Ala Glu 
            260                 265                 270         


Asp Asn Ala Arg Asn Glu Thr Leu Ser Asn Arg Tyr Leu Gln Pro Thr 
        275                 280                 285             


Gln Val Ser Glu Gln Glu Ile Gln Gly Gln Glu Leu Ala Glu Leu Thr 
    290                 295                 300                 


Gly Val Thr Val Glu Leu Pro Glu Glu Pro Gln Arg Leu Leu Glu Gln 
305                 310                 315                 320 


Ala Glu Ala Glu Gly Cys Gln Arg Arg Arg Leu Leu Val Pro Val Asn 
                325                 330                 335     


Asp Ala Asp Ser Ala Asp Ile Ser Thr Leu Leu Asp Ala Ser Ala Thr 
            340                 345                 350         


Leu Glu Glu Gly His Ala Lys Glu Thr Ile Gln Asp Gln Leu Val Gly 
        355                 360                 365             


Ser Glu Lys Leu Phe Tyr Glu Glu Asp Glu Ala Gly Ser Ala Thr Ser 
    370                 375                 380                 


Cys Leu 
385     


<210>  376
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  376

Met Ala Pro Arg Ala Arg Arg Arg Arg Pro Leu Phe Ala Leu Leu Leu 
1               5                   10                  15      


Leu Cys Ala Leu Leu Ala Arg Leu Gln Val Ala Leu Gln Ile Ala Pro 
            20                  25                  30          


Pro Cys Thr Ser Glu Lys His Tyr Glu His Leu Gly Arg Cys Cys Asn 
        35                  40                  45              


Lys Cys Glu Pro Gly Lys Tyr Met Ser Ser Lys Cys Thr Thr Thr Ser 
    50                  55                  60                  


Asp Ser Val Cys Leu Pro Cys Gly Pro Asp Glu Tyr Leu Asp Ser Trp 
65                  70                  75                  80  


Asn Glu Glu Asp Lys Cys Leu Leu His Lys Val Cys Asp Thr Gly Lys 
                85                  90                  95      


Ala Leu Val Ala Val Val Ala Gly Asn Ser Thr Thr Pro Arg Arg Cys 
            100                 105                 110         


Ala Cys Thr Ala Gly Tyr His Trp Ser Gln Asp Cys Glu Cys Cys Arg 
        115                 120                 125             


Arg Asn Thr Glu Cys Ala Pro Gly Leu Gly Ala Gln His Pro Leu Gln 
    130                 135                 140                 


Leu Asn Lys Asp Thr Val Cys Lys Pro Cys Leu Ala Gly Tyr Phe Ser 
145                 150                 155                 160 


Asp Ala Phe Ser Ser Thr Asp Lys Cys Arg Pro Trp Thr Asn Cys Thr 
                165                 170                 175     


Phe Leu Gly Lys Arg Val Glu His His Gly Thr Glu Lys Ser Asp Ala 
            180                 185                 190         


Val Cys Ser Ser Ser Leu Pro Ala Arg Lys Pro Pro Asn Glu Pro His 
        195                 200                 205             


Val Tyr Leu Pro Gly Leu Ile Ile Leu Leu Leu Phe Ala Ser Val Ala 
    210                 215                 220                 


Leu Val Ala Ala Ile Ile Phe Gly Val Cys Tyr Arg Lys Lys Gly Lys 
225                 230                 235                 240 


Ala Leu Thr Ala Asn Leu Trp His Trp Ile Asn Glu Ala Cys Gly Arg 
                245                 250                 255     


Leu Ser Gly Asp Lys Glu Met 
            260             


<210>  377
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  377

Met Asn Asn Leu Leu Cys Cys Ala Leu Val Phe Leu Asp Ile Ser Ile 
1               5                   10                  15      


Lys Trp Thr Thr Gln Glu Thr Phe Pro Pro Lys Tyr Leu His Tyr Asp 
            20                  25                  30          


Glu Glu Thr Ser His Gln Leu Leu Cys Asp Lys Cys Pro Pro Gly Thr 
        35                  40                  45              


Tyr Leu Lys Gln His Cys Thr Ala Lys Trp Lys Thr Val Cys Ala Pro 
    50                  55                  60                  


Cys Pro Asp His Tyr Tyr Thr Asp Ser Trp His Thr Ser Asp Glu Cys 
65                  70                  75                  80  


Leu Tyr Cys Ser Pro Val Cys Lys Glu Leu Gln Tyr Val Lys Gln Glu 
                85                  90                  95      


Cys Asn Arg Thr His Asn Arg Val Cys Glu Cys Lys Glu Gly Arg Tyr 
            100                 105                 110         


Leu Glu Ile Glu Phe Cys Leu Lys His Arg Ser Cys Pro Pro Gly Phe 
        115                 120                 125             


Gly Val Val Gln Ala Gly Thr Pro Glu Arg Asn Thr Val Cys Lys Arg 
    130                 135                 140                 


Cys Pro Asp Gly Phe Phe Ser Asn Glu Thr Ser Ser Lys Ala Pro Cys 
145                 150                 155                 160 


Arg Lys His Thr Asn Cys Ser Val Phe Gly Leu Leu Leu Thr Gln Lys 
                165                 170                 175     


Gly Asn Ala Thr His Asp Asn Ile Cys Ser Gly Asn Ser Glu Ser Thr 
            180                 185                 190         


Gln Lys Cys Gly Ile Asp Val Thr Leu Cys Glu Glu Ala Phe Phe Arg 
        195                 200                 205             


Phe Ala Val Pro Thr Lys Phe Thr Pro Asn Trp Leu Ser Val Leu Val 
    210                 215                 220                 


Asp Asn Leu Pro Gly Thr Lys Val Asn Ala Glu Ser Val Glu Arg Ile 
225                 230                 235                 240 


Lys Arg Gln His Ser Ser Gln Glu Gln Thr Phe Gln Leu Leu Lys Leu 
                245                 250                 255     


Trp Lys His Gln Asn Lys Asp Gln Asp Ile Val Lys Lys Ile Ile Gln 
            260                 265                 270         


Asp Ile Asp Leu Cys Glu Asn Ser Val Gln Arg His Ile Gly His Ala 
        275                 280                 285             


Asn Leu Thr Phe Glu Gln Leu Arg Ser Leu Met Glu Ser Leu Pro Gly 
    290                 295                 300                 


Lys Lys Val Gly Ala Glu Asp Ile Glu Lys Thr Ile Lys Ala Cys Lys 
305                 310                 315                 320 


Pro Ser Asp Gln Ile Leu Lys Leu Leu Ser Leu Trp Arg Ile Lys Asn 
                325                 330                 335     


Gly Asp Gln Asp Thr Leu Lys Gly Leu Met His Ala Leu Lys His Ser 
            340                 345                 350         


Lys Thr Tyr His Phe Pro Lys Thr Val Thr Gln Ser Leu Lys Lys Thr 
        355                 360                 365             


Ile Arg Phe Leu His Ser Phe Thr Met Tyr Lys Leu Tyr Gln Lys Leu 
    370                 375                 380                 


Phe Leu Glu Met Ile Gly Asn Gln Val Gln Ser Val Lys Ile Ser Cys 
385                 390                 395                 400 


Leu 
    


<210>  378
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  378

Met Glu Gln Arg Pro Arg Gly Cys Ala Ala Val Ala Ala Ala Leu Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Ala Arg Ala Gln Gly Gly Thr Arg Ser Pro Arg 
            20                  25                  30          


Cys Asp Cys Ala Gly Asp Phe His Lys Lys Ile Gly Leu Phe Cys Cys 
        35                  40                  45              


Arg Gly Cys Pro Ala Gly His Tyr Leu Lys Ala Pro Cys Thr Glu Pro 
    50                  55                  60                  


Cys Gly Asn Ser Thr Cys Leu Val Cys Pro Gln Asp Thr Phe Leu Ala 
65                  70                  75                  80  


Trp Glu Asn His His Asn Ser Glu Cys Ala Arg Cys Gln Ala Cys Asp 
                85                  90                  95      


Glu Gln Ala Ser Gln Val Ala Leu Glu Asn Cys Ser Ala Val Ala Asp 
            100                 105                 110         


Thr Arg Cys Gly Cys Lys Pro Gly Trp Phe Val Glu Cys Gln Val Ser 
        115                 120                 125             


Gln Cys Val Ser Ser Ser Pro Phe Tyr Cys Gln Pro Cys Leu Asp Cys 
    130                 135                 140                 


Gly Ala Leu His Arg His Thr Arg Leu Leu Cys Ser Arg Arg Asp Thr 
145                 150                 155                 160 


Asp Cys Gly Thr Cys Leu Pro Gly Phe Tyr Glu His Gly Asp Gly Cys 
                165                 170                 175     


Val Ser Cys Pro Thr 
            180     


<210>  379
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  379

Met Ala Arg Gly Ser Leu Arg Arg Leu Leu Arg Leu Leu Val Leu Gly 
1               5                   10                  15      


Leu Trp Leu Ala Leu Leu Arg Ser Val Ala Gly Glu Gln Ala Pro Gly 
            20                  25                  30          


Thr Ala Pro Cys Ser Arg Gly Ser Ser Trp Ser Ala Asp Leu Asp Lys 
        35                  40                  45              


Cys Met Asp Cys Ala Ser Cys Arg Ala Arg Pro His Ser Asp Phe Cys 
    50                  55                  60                  


Leu Gly Cys Ala Ala Ala Pro Pro Ala Pro Phe Arg Leu Leu Trp Pro 
65                  70                  75                  80  


Ile Leu Gly Gly Ala Leu Ser Leu Thr Phe Val Leu Gly Leu Leu Ser 
                85                  90                  95      


Gly Phe Leu Val Trp Arg Arg Cys Arg Arg Arg Glu Lys Phe Thr Thr 
            100                 105                 110         


Pro Ile Glu Glu Thr Gly Gly Glu Gly Cys Pro Ala Val Ala Leu Ile 
        115                 120                 125             


Gln 
    


<210>  380
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  380

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  381
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  381

Met Arg Arg Gly Pro Arg Ser Leu Arg Gly Arg Asp Ala Pro Ala Pro 
1               5                   10                  15      


Thr Pro Cys Val Pro Ala Glu Cys Phe Asp Leu Leu Val Arg His Cys 
            20                  25                  30          


Val Ala Cys Gly Leu Leu Arg Thr Pro Arg Pro Lys Pro Ala Gly Ala 
        35                  40                  45              


Ser Ser Pro Ala Pro Arg Thr Ala Leu Gln Pro Gln Glu Ser Val Gly 
    50                  55                  60                  


Ala Gly Ala Gly Glu Ala Ala Leu Pro Leu Pro Gly Leu Leu Phe Gly 
65                  70                  75                  80  


Ala Pro Ala Leu Leu Gly Leu Ala Leu Val Leu Ala Leu Val Leu Val 
                85                  90                  95      


Gly Leu Val Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser 
            100                 105                 110         


Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp 
        115                 120                 125             


Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala 
    130                 135                 140                 


Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser 
145                 150                 155                 160 


Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr 
                165                 170                 175     


Lys Thr Ala Gly Pro Glu Gln Gln 
            180                 


<210>  382
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  382

Met Glu Pro Pro Gly Asp Trp Gly Pro Pro Pro Trp Arg Ser Thr Pro 
1               5                   10                  15      


Lys Thr Asp Val Leu Arg Leu Val Leu Tyr Leu Thr Phe Leu Gly Ala 
            20                  25                  30          


Pro Cys Tyr Ala Pro Ala Leu Pro Ser Cys Lys Glu Asp Glu Tyr Pro 
        35                  40                  45              


Val Gly Ser Glu Cys Cys Pro Lys Cys Ser Pro Gly Tyr Arg Val Lys 
    50                  55                  60                  


Glu Ala Cys Gly Glu Leu Thr Gly Thr Val Cys Glu Pro Cys Pro Pro 
65                  70                  75                  80  


Gly Thr Tyr Ile Ala His Leu Asn Gly Leu Ser Lys Cys Leu Gln Cys 
                85                  90                  95      


Gln Met Cys Asp Pro Ala Met Gly Leu Arg Ala Ser Arg Asn Cys Ser 
            100                 105                 110         


Arg Thr Glu Asn Ala Val Cys Gly Cys Ser Pro Gly His Phe Cys Ile 
        115                 120                 125             


Val Gln Asp Gly Asp His Cys Ala Ala Cys Arg Ala Tyr Ala Thr Ser 
    130                 135                 140                 


Ser Pro Gly Gln Arg Val Gln Lys Gly Gly Thr Glu Ser Gln Asp Thr 
145                 150                 155                 160 


Leu Cys Gln Asn Cys Pro Pro Gly Thr Phe Ser Pro Asn Gly Thr Leu 
                165                 170                 175     


Glu Glu Cys Gln His Gln Thr Lys Cys Ser Trp Leu Val Thr Lys Ala 
            180                 185                 190         


Gly Ala Gly Thr Ser Ser Ser His Trp Val Trp Trp Phe Leu Ser Gly 
        195                 200                 205             


Ser Leu Val Ile Val Ile Val Cys Ser Thr Val Gly Leu Ile Ile Cys 
    210                 215                 220                 


Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val Ser 
225                 230                 235                 240 


Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile Glu 
                245                 250                 255     


Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu Thr 
            260                 265                 270         


Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
        275                 280             


<210>  383
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
        275                 280                 285             


Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
    290                 295                 300                 


Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 
305                 310                 315                 320 


Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 
                325                 330                 335     


Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 
            340                 345                 350         


Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 
        355                 360                 365             


Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 
    370                 375                 380                 


Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 
385                 390                 395                 400 


Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 
                405                 410                 415     


Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
            420                 425         


<210>  384
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  384

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  385
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  386
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  386

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Glu 
                405                 410                 415     


Ala 
    


<210>  387
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  387

Met Lys Pro Ser Leu Leu Cys Arg Pro Leu Ser Cys Phe Leu Met Leu 
1               5                   10                  15      


Leu Pro Trp Pro Leu Ala Thr Leu Thr Ser Thr Thr Leu Trp Gln Cys 
            20                  25                  30          


Pro Pro Gly Glu Glu Pro Asp Leu Asp Pro Gly Gln Gly Thr Leu Cys 
        35                  40                  45              


Arg Pro Cys Pro Pro Gly Thr Phe Ser Ala Ala Trp Gly Ser Ser Pro 
    50                  55                  60                  


Cys Gln Pro His Ala Arg Cys Ser Leu Trp Arg Arg Leu Glu Ala Gln 
65                  70                  75                  80  


Val Gly Met Ala Thr Arg Asp Thr Leu Cys Gly Asp Cys Trp Pro Gly 
                85                  90                  95      


Trp Phe Gly Pro Trp Gly Val Pro Arg Val Pro Cys Gln Pro Cys Ser 
            100                 105                 110         


Trp Ala Pro Leu Gly Thr His Gly Cys Asp Glu Trp Gly Arg Arg Ala 
        115                 120                 125             


Arg Arg Gly Val Glu Val Ala Ala Gly Ala Ser Ser Gly Gly Glu Thr 
    130                 135                 140                 


Arg Gln Pro Gly Asn Gly Thr Arg Ala Gly Gly Pro Glu Glu Thr Ala 
145                 150                 155                 160 


Ala Gln Tyr Ala Val Ile Ala Ile Val Pro Val Phe Cys Leu Met Gly 
                165                 170                 175     


Leu Leu Gly Ile Leu Val Cys Asn Leu Leu Lys Arg Lys Gly Tyr His 
            180                 185                 190         


Cys Thr Ala His Lys Glu Val Gly Pro Gly Pro Gly Gly Gly Gly Ser 
        195                 200                 205             


Gly Ile Asn Pro Ala Tyr Arg Thr Glu Asp Ala Asn Glu Asp Thr Ile 
    210                 215                 220                 


Gly Val Leu Val Arg Leu Ile Thr Glu Lys Lys Glu Asn Ala Ala Ala 
225                 230                 235                 240 


Leu Glu Glu Leu Leu Lys Glu Tyr His Ser Lys Gln Leu Val Gln Thr 
                245                 250                 255     


Ser His Arg Pro Val Ser Lys Leu Pro Pro Ala Pro Pro Asn Val Pro 
            260                 265                 270         


His Ile Cys Pro His Arg His His Leu His Thr Val Gln Gly Leu Ala 
        275                 280                 285             


Ser Leu Ser Gly Pro Cys Cys Ser Arg Cys Ser Gln Lys Lys Trp Pro 
    290                 295                 300                 


Glu Val Leu Leu Ser Pro Glu Ala Val Ala Ala Thr Thr Pro Val Pro 
305                 310                 315                 320 


Ser Leu Leu Pro Asn Pro Thr Arg Val Pro Lys Ala Gly Ala Lys Ala 
                325                 330                 335     


Gly Arg Gln Gly Glu Ile Thr Ile Leu Ser Val Gly Arg Phe Arg Val 
            340                 345                 350         


Ala Arg Ile Pro Glu Gln Arg Thr Ser Ser Met Val Ser Glu Val Lys 
        355                 360                 365             


Thr Ile Thr Glu Ala Gly Pro Ser Trp Gly Asp Leu Pro Asp Ser Pro 
    370                 375                 380                 


Gln Pro Gly Leu Pro Pro Glu Gln Gln Ala Leu Leu Gly Ser Gly Gly 
385                 390                 395                 400 


Ser Arg Thr Lys Trp Leu Lys Pro Pro Ala Glu Asn Lys Ala Glu Glu 
                405                 410                 415     


Asn Arg Tyr Val Val Arg Leu Ser Glu Ser Asn Leu Val Ile 
            420                 425                 430 


<210>  388
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  388

Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Thr Thr Ala Gln Pro Glu Gln Lys Ala Ser 
        35                  40                  45              


Asn Leu Ile Gly Thr Tyr Arg His Val Asp Arg Ala Thr Gly Gln Val 
    50                  55                  60                  


Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys 
65                  70                  75                  80  


Thr Asn Thr Ser Leu Arg Val Cys Ser Ser Cys Pro Val Gly Thr Phe 
                85                  90                  95      


Thr Arg His Glu Asn Gly Ile Glu Lys Cys His Asp Cys Ser Gln Pro 
            100                 105                 110         


Cys Pro Trp Pro Met Ile Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp 
        115                 120                 125             


Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys 
    130                 135                 140                 


Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly 
145                 150                 155                 160 


Thr Glu Thr Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe 
                165                 170                 175     


Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala Tyr Thr Asp Cys 
            180                 185                 190         


Leu Ser Gln Asn Leu Val Val Ile Lys Pro Gly Thr Lys Glu Thr Asp 
        195                 200                 205             


Asn Val Cys Gly Thr Leu Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser 
    210                 215                 220                 


Pro Gly Thr Ala Ile Phe Pro Arg Pro Glu His Met Glu Thr His Glu 
225                 230                 235                 240 


Val Pro Ser Ser Thr Tyr Val Pro Lys Gly Met Asn Ser Thr Glu Ser 
                245                 250                 255     


Asn Ser Ser Ala Ser Val Arg Pro Lys Val Leu Ser Ser Ile Gln Glu 
            260                 265                 270         


Gly Thr Val Pro Asp Asn Thr Ser Ser Ala Arg Gly Lys Glu Asp Val 
        275                 280                 285             


Asn Lys Thr Leu Pro Asn Leu Gln Val Val Asn His Gln Gln Gly Pro 
    290                 295                 300                 


His His Arg His Ile Leu Lys Leu Leu Pro Ser Met Glu Ala Thr Gly 
305                 310                 315                 320 


Gly Glu Lys Ser Ser Thr Pro Ile Lys Gly Pro Lys Arg Gly His Pro 
                325                 330                 335     


Arg Gln Asn Leu His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp 
            340                 345                 350         


Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Val Ile Val Val Cys 
        355                 360                 365             


Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp 
    370                 375                 380                 


Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Met Thr Pro 
385                 390                 395                 400 


Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Cys Asn Gly His Gly Ile 
                405                 410                 415     


Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp 
            420                 425                 430         


Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe 
        435                 440                 445             


Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln 
    450                 455                 460                 


His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser 
465                 470                 475                 480 


Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly 
                485                 490                 495     


Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro 
            500                 505                 510         


Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Ile Pro Ser Pro Asn Ala 
        515                 520                 525             


Lys Leu Glu Asn Ser Ala Leu Leu Thr Val Glu Pro Ser Pro Gln Asp 
    530                 535                 540                 


Lys Asn Lys Gly Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys 
545                 550                 555                 560 


Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe 
                565                 570                 575     


Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp 
            580                 585                 590         


Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Phe Leu Asn 
        595                 600                 605             


Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys 
    610                 615                 620                 


Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser 
625                 630                 635                 640 


Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu 
                645                 650                 655 


<210>  389
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  389

Met Phe Gly Phe Phe Cys Ser Leu Val Ser Ser Leu Ser Arg Trp Phe 
1               5                   10                  15      


Leu Trp Arg Arg Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Asn Leu 
            20                  25                  30          


Pro Leu Gln Val Lys Phe Ala Met Leu Glu Leu His Ser Phe Lys Cys 
        35                  40                  45              


Pro Ala Gly Glu Tyr Trp Ser Lys Asp Val Cys Cys Lys Asn Cys Ser 
    50                  55                  60                  


Ala Gly Thr Phe Val Lys Ala Pro Cys Glu Ile Pro His Thr Gln Gly 
65                  70                  75                  80  


Gln Cys Glu Lys Cys His Pro Gly Thr Phe Thr Glu Lys Asp Asn Tyr 
                85                  90                  95      


Leu Asp Ala Cys Ile Leu Cys Ser Thr Cys Asp Lys Asp Gln Glu Met 
            100                 105                 110         


Val Ala Asp Cys Ser Ala Thr Ser Asp Arg Lys Cys Gln Cys Arg Thr 
        115                 120                 125             


Gly Leu Tyr Tyr Tyr Asp Pro Lys Phe Pro Glu Ser Cys Arg Pro Cys 
    130                 135                 140                 


Thr Lys Cys Pro Gln Gly Ile Pro Val Leu Gln Glu Cys Asn Ser Thr 
145                 150                 155                 160 


Ala Asn Thr Val Cys Ser Ser Ser Val Ser Asn Pro Arg Asn Arg Leu 
                165                 170                 175     


Phe Leu Leu Leu Ser Pro Leu Ser Val Leu Ile Val Ser Val Val Val 
            180                 185                 190         


Phe Arg Ile Ile Arg Arg 
        195             


<210>  390
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  390

Met Val Thr Phe Ser His Val Ser Ser Leu Ser His Trp Phe Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Asn Leu Phe Leu Pro Val Ile Phe Ala Met Pro Glu 
            20                  25                  30          


Ser Tyr Ser Phe Asn Cys Pro Asp Gly Glu Tyr Gln Ser Asn Asp Val 
        35                  40                  45              


Cys Cys Lys Thr Cys Pro Ser Gly Thr Phe Val Lys Ala Pro Cys Lys 
    50                  55                  60                  


Ile Pro His Thr Gln Gly Gln Cys Glu Lys Cys His Pro Gly Thr Phe 
65                  70                  75                  80  


Thr Gly Lys Asp Asn Gly Leu His Asp Cys Glu Leu Cys Ser Thr Cys 
                85                  90                  95      


Asp Lys Asp Gln Asn Met Val Ala Asp Cys Ser Ala Thr Ser Asp Arg 
            100                 105                 110         


Lys Cys Glu Cys Gln Ile Gly Leu Tyr Tyr Tyr Asp Pro Lys Phe Pro 
        115                 120                 125             


Glu Ser Cys Arg Pro Cys Thr Lys Cys Pro Gln Gly Ile Pro Val Leu 
    130                 135                 140                 


Gln Glu Cys Asn Ser Thr Ala Asn Thr Val Cys Ser Ser Ser Val Ser 
145                 150                 155                 160 


Asn Pro Arg Asn Trp Leu Phe Leu Leu Met Leu Ile Val Phe Cys Ile 
                165                 170                 175     


<210>  391
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  391

Met Asp Cys Gln Glu Asn Glu Tyr Trp Asp Gln Trp Gly Arg Cys Val 
1               5                   10                  15      


Thr Cys Gln Arg Cys Gly Pro Gly Gln Glu Leu Ser Lys Asp Cys Gly 
            20                  25                  30          


Tyr Gly Glu Gly Gly Asp Ala Tyr Cys Thr Ala Cys Pro Pro Arg Arg 
        35                  40                  45              


Tyr Lys Ser Ser Trp Gly His His Arg Cys Gln Ser Cys Ile Thr Cys 
    50                  55                  60                  


Ala Val Ile Asn Arg Val Gln Lys Val Asn Cys Thr Ala Thr Ser Asn 
65                  70                  75                  80  


Ala Val Cys Gly Asp Cys Leu Pro Arg Phe Tyr Arg Lys Thr Arg Ile 
                85                  90                  95      


Gly Gly Leu Gln Asp Gln Glu Cys Ile Pro Cys Thr Lys Gln Thr Pro 
            100                 105                 110         


Thr Ser Glu Val Gln Cys Ala Phe Gln Leu Ser Leu Val Glu Ala Asp 
        115                 120                 125             


Ala Pro Thr Val Pro Pro Gln Glu Ala Thr Leu Val Ala Leu Val Ser 
    130                 135                 140                 


Ser Leu Leu Val Val Phe Thr Leu Ala Phe Leu Gly Leu Phe Phe Leu 
145                 150                 155                 160 


Tyr Cys Lys Gln Phe Phe Asn Arg His Cys Gln Arg Gly Gly Leu Leu 
                165                 170                 175     


Gln Phe Glu Ala Asp Lys Thr Ala Lys Glu Glu Ser Leu Phe Pro Val 
            180                 185                 190         


Pro Pro Ser Lys Glu Thr Ser Ala Glu Ser Gln Val Ser Glu Asn Ile 
        195                 200                 205             


Phe Gln Thr Gln Pro Leu Asn Pro Ile Leu Glu Asp Asp Cys Ser Ser 
    210                 215                 220                 


Thr Ser Gly Phe Pro Thr Gln Glu Ser Phe Thr Met Ala Ser Cys Thr 
225                 230                 235                 240 


Ser Glu Ser His Ser His Trp Val His Ser Pro Ile Glu Cys Thr Glu 
                245                 250                 255     


Leu Asp Leu Gln Lys Phe Ser Ser Ser Ala Ser Tyr Thr Gly Ala Glu 
            260                 265                 270         


Thr Leu Gly Gly Asn Thr Val Glu Ser Thr Gly Asp Arg Leu Glu Leu 
        275                 280                 285             


Asn Val Pro Phe Glu Val Pro Ser Pro 
    290                 295         


<210>  392
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  392

Met Ala His Val Gly Asp Cys Thr Gln Thr Pro Trp Leu Pro Val Leu 
1               5                   10                  15      


Val Val Ser Leu Met Cys Ser Ala Arg Ala Glu Tyr Ser Asn Cys Gly 
            20                  25                  30          


Glu Asn Glu Tyr Tyr Asn Gln Thr Thr Gly Leu Cys Gln Glu Cys Pro 
        35                  40                  45              


Pro Cys Gly Pro Gly Glu Glu Pro Tyr Leu Ser Cys Gly Tyr Gly Thr 
    50                  55                  60                  


Lys Asp Glu Asp Tyr Gly Cys Val Pro Cys Pro Ala Glu Lys Phe Ser 
65                  70                  75                  80  


Lys Gly Gly Tyr Gln Ile Cys Arg Arg His Lys Asp Cys Glu Gly Phe 
                85                  90                  95      


Phe Arg Ala Thr Val Leu Thr Pro Gly Asp Met Glu Asn Asp Ala Glu 
            100                 105                 110         


Cys Gly Pro Cys Leu Pro Gly Tyr Tyr Met Leu Glu Asn Arg Pro Arg 
        115                 120                 125             


Asn Ile Tyr Gly Met Val Cys Tyr Ser Cys Leu Leu Ala Pro Pro Asn 
    130                 135                 140                 


Thr Lys Glu Cys Val Gly Ala Thr Ser Gly Ala Ser Ala Asn Phe Pro 
145                 150                 155                 160 


Gly Thr Ser Gly Ser Ser Thr Leu Ser Pro Phe Gln His Ala His Lys 
                165                 170                 175     


Glu Leu Ser Gly Gln Gly His Leu Ala Thr Ala Leu Ile Ile Ala Met 
            180                 185                 190         


Ser Thr Ile Phe Ile Met Ala Ile Ala Ile Val Leu Ile Ile Met Phe 
        195                 200                 205             


Tyr Ile Leu Lys Thr Lys Pro Ser Ala Pro Ala Cys Cys Thr Ser His 
    210                 215                 220                 


Pro Gly Lys Ser Val Glu Ala Gln Val Ser Lys Asp Glu Glu Lys Lys 
225                 230                 235                 240 


Glu Ala Pro Asp Asn Val Val Met Phe Ser Glu Lys Asp Glu Phe Glu 
                245                 250                 255     


Lys Leu Thr Ala Thr Pro Ala Lys Pro Thr Lys Ser Glu Asn Asp Ala 
            260                 265                 270         


Ser Ser Glu Asn Glu Gln Leu Leu Ser Arg Ser Val Asp Ser Asp Glu 
        275                 280                 285             


Glu Pro Ala Pro Asp Lys Gln Gly Ser Pro Glu Leu Cys Leu Leu Ser 
    290                 295                 300                 


Leu Val His Leu Ala Arg Glu Lys Ser Ala Thr Ser Asn Lys Ser Ala 
305                 310                 315                 320 


Gly Ile Gln Ser Arg Arg Lys Lys Ile Leu Asp Val Tyr Ala Asn Val 
                325                 330                 335     


Cys Gly Val Val Glu Gly Leu Ser Pro Thr Glu Leu Pro Phe Asp Cys 
            340                 345                 350         


Leu Glu Lys Thr Ser Arg Met Leu Ser Ser Thr Tyr Asn Ser Glu Lys 
        355                 360                 365             


Ala Val Val Lys Thr Trp Arg His Leu Ala Glu Ser Phe Gly Leu Lys 
    370                 375                 380                 


Arg Asp Glu Ile Gly Gly Met Thr Asp Gly Met Gln Leu Phe Asp Arg 
385                 390                 395                 400 


Ile Ser Thr Ala Gly Tyr Ser Ile Pro Glu Leu Leu Thr Lys Leu Val 
                405                 410                 415     


Gln Ile Glu Arg Leu Asp Ala Val Glu Ser Leu Cys Ala Asp Ile Leu 
            420                 425                 430         


Glu Trp Ala Gly Val Val Pro Pro Ala Ser Gln Pro His Ala Ala Ser 
        435                 440                 445             


<210>  393
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  394
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  394

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  395
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  396
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  396

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  397
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  397

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  398
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  398

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  399
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  399

Met Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val 
1               5                   10                  15      


Val Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr 
            20                  25                  30          


Tyr Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu 
        35                  40                  45              


Pro Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His 
    50                  55                  60                  


Phe Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly 
65                  70                  75                  80  


Met Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val 
                85                  90                  95      


Gln Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser 
            100                 105                 110         


Lys Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile 
        115                 120                 125             


Pro Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala 
    130                 135                 140                 


Met Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile 
145                 150                 155                 160 


Gln Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met 
                165                 170                 175     


Ser Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn 
            180                 185                 190         


Phe Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val 
        195                 200                 205             


Phe Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr 
    210                 215                 220                 


Val Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln 
225                 230                 235                 240 


Leu Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys 
                245                 250                 255     


Cys Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn 
            260                 265                 270         


Asp Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln 
        275                 280                 285             


Leu Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser 
    290                 295                 300                 


Val Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
305                 310                 315 


<210>  400
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  400

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  401
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  401

Met Ala Asp Asp Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr 
1               5                   10                  15      


Val Asn Phe Asn Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg 
            20                  25                  30          


Gln Phe Ala Ser His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile 
        35                  40                  45              


Val Gly Ala Leu Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys 
    50                  55                  60                  


Thr Arg Val Lys Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile 
65                  70                  75                  80  


Ala Asp Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala 
                85                  90                  95      


Ala Asp Gln Trp Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser 
            100                 105                 110         


Met Tyr Lys Met Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile 
        115                 120                 125             


Ser Val Asp Arg Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr 
    130                 135                 140                 


Trp Arg Glu Lys Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile 
145                 150                 155                 160 


Trp Val Leu Ala Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln 
                165                 170                 175     


Ile Lys Glu Glu Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser 
            180                 185                 190         


Asp Glu Ser Thr Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile 
        195                 200                 205             


Leu Gly Phe Phe Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile 
    210                 215                 220                 


Ile Ile His Thr Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala 
225                 230                 235                 240 


Leu Lys Val Thr Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe 
                245                 250                 255     


Pro Tyr Asn Cys Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met 
            260                 265                 270         


Phe Ile Ser Asn Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln 
        275                 280                 285             


Val Thr Gln Thr Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu 
    290                 295                 300                 


Tyr Val Phe Val Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu 
305                 310                 315                 320 


Lys Asn Leu Gly Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg 
                325                 330                 335     


Arg Glu Gly Ser Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser 
            340                 345                 350         


Gly Ala Leu Ser Leu 
        355         


<210>  402
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  402

Met Gly Thr Glu Ala Thr Glu Gln Val Ser Trp Gly His Tyr Ser Gly 
1               5                   10                  15      


Asp Glu Glu Asp Ala Tyr Ser Ala Glu Pro Leu Pro Glu Leu Cys Tyr 
            20                  25                  30          


Lys Ala Asp Val Gln Ala Phe Ser Arg Ala Phe Gln Pro Ser Val Ser 
        35                  40                  45              


Leu Thr Val Ala Ala Leu Gly Leu Ala Gly Asn Gly Leu Val Leu Ala 
    50                  55                  60                  


Thr His Leu Ala Ala Arg Arg Ala Ala Arg Ser Pro Thr Ser Ala His 
65                  70                  75                  80  


Leu Leu Gln Leu Ala Leu Ala Asp Leu Leu Leu Ala Leu Thr Leu Pro 
                85                  90                  95      


Phe Ala Ala Ala Gly Ala Leu Gln Gly Trp Ser Leu Gly Ser Ala Thr 
            100                 105                 110         


Cys Arg Thr Ile Ser Gly Leu Tyr Ser Ala Ser Phe His Ala Gly Phe 
        115                 120                 125             


Leu Phe Leu Ala Cys Ile Ser Ala Asp Arg Tyr Val Ala Ile Ala Arg 
    130                 135                 140                 


Ala Leu Pro Ala Gly Pro Arg Pro Ser Thr Pro Gly Arg Ala His Leu 
145                 150                 155                 160 


Val Ser Val Ile Val Trp Leu Leu Ser Leu Leu Leu Ala Leu Pro Ala 
                165                 170                 175     


Leu Leu Phe Ser Gln Asp Gly Gln Arg Glu Gly Gln Arg Arg Cys Arg 
            180                 185                 190         


Leu Ile Phe Pro Glu Gly Leu Thr Gln Thr Val Lys Gly Ala Ser Ala 
        195                 200                 205             


Val Ala Gln Val Ala Leu Gly Phe Ala Leu Pro Leu Gly Val Met Val 
    210                 215                 220                 


Ala Cys Tyr Ala Leu Leu Gly Arg Thr Leu Leu Ala Ala Arg Gly Pro 
225                 230                 235                 240 


Glu Arg Arg Arg Ala Leu Arg Val Val Val Ala Leu Val Ala Ala Phe 
                245                 250                 255     


Val Val Leu Gln Leu Pro Tyr Ser Leu Ala Leu Leu Leu Asp Thr Ala 
            260                 265                 270         


Asp Leu Leu Ala Ala Arg Glu Arg Ser Cys Pro Ala Ser Lys Arg Lys 
        275                 280                 285             


Asp Val Ala Leu Leu Val Thr Ser Gly Leu Ala Leu Ala Arg Cys Gly 
    290                 295                 300                 


Leu Asn Pro Val Leu Tyr Ala Phe Leu Gly Leu Arg Phe Arg Gln Asp 
305                 310                 315                 320 


Leu Arg Arg Leu Leu Arg Gly Gly Ser Cys Pro Ser Gly Pro Gln Pro 
                325                 330                 335     


Arg Arg Gly Cys Pro Arg Arg Pro Arg Leu Ser Ser Cys Ser Ala Pro 
            340                 345                 350         


Thr Glu Thr His Ser Leu Ser Trp Asp Asn 
        355                 360         


<210>  403
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Ser Asn Ile Thr Asp Pro Gln Met Trp Asp Phe Asp Asp Leu Asn 
1               5                   10                  15      


Phe Thr Gly Met Pro Pro Ala Asp Glu Asp Tyr Ser Pro Cys Met Leu 
            20                  25                  30          


Glu Thr Glu Thr Leu Asn Lys Tyr Val Val Ile Ile Ala Tyr Ala Leu 
        35                  40                  45              


Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met Leu Val Ile 
    50                  55                  60                  


Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro Ile Trp Ala 
                85                  90                  95      


Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu Cys Lys Val 
            100                 105                 110         


Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His Ala Thr Arg 
    130                 135                 140                 


Thr Leu Thr Gln Lys Arg His Leu Val Lys Phe Val Cys Leu Gly Cys 
145                 150                 155                 160 


Trp Gly Leu Ser Met Asn Leu Ser Leu Pro Phe Phe Leu Phe Arg Gln 
                165                 170                 175     


Ala Tyr His Pro Asn Asn Ser Ser Pro Val Cys Tyr Glu Val Leu Gly 
            180                 185                 190         


Asn Asp Thr Ala Lys Trp Arg Met Val Leu Arg Ile Leu Pro His Thr 
        195                 200                 205             


Phe Gly Phe Ile Val Pro Leu Phe Val Met Leu Phe Cys Tyr Gly Phe 
    210                 215                 220                 


Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys His Arg Ala 
225                 230                 235                 240 


Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu Cys Trp Leu 
                245                 250                 255     


Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg Thr Gln Val 
            260                 265                 270         


Ile Gln Glu Ser Cys Glu Arg Arg Asn Asn Ile Gly Arg Ala Leu Asp 
        275                 280                 285             


Ala Thr Glu Ile Leu Gly Phe Leu His Ser Cys Leu Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Ile Gly Gln Asn Phe Arg His Gly Phe Leu Lys Ile Leu 
305                 310                 315                 320 


Ala Met His Gly Leu Val Ser Lys Glu Phe Leu Ala Arg His Arg Val 
                325                 330                 335     


Thr Ser Tyr Thr Ser Ser Ser Val Asn Val Ser Ser Asn Leu 
            340                 345                 350 


<210>  404
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  404

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  405
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Glu Leu Arg Lys Tyr Gly Pro Gly Arg Leu Ala Gly Thr Val Ile 
1               5                   10                  15      


Gly Gly Ala Ala Gln Ser Lys Ser Gln Thr Lys Ser Asp Ser Ile Thr 
            20                  25                  30          


Lys Glu Phe Leu Pro Gly Leu Tyr Thr Ala Pro Ser Ser Pro Phe Pro 
        35                  40                  45              


Pro Ser Gln Val Ser Asp His Gln Val Leu Asn Asp Ala Glu Val Ala 
    50                  55                  60                  


Ala Leu Leu Glu Asn Phe Ser Ser Ser Tyr Asp Tyr Gly Glu Asn Glu 
65                  70                  75                  80  


Ser Asp Ser Cys Cys Thr Ser Pro Pro Cys Pro Gln Asp Phe Ser Leu 
                85                  90                  95      


Asn Phe Asp Arg Ala Phe Leu Pro Ala Leu Tyr Ser Leu Leu Phe Leu 
            100                 105                 110         


Leu Gly Leu Leu Gly Asn Gly Ala Val Ala Ala Val Leu Leu Ser Arg 
        115                 120                 125             


Arg Thr Ala Leu Ser Ser Thr Asp Thr Phe Leu Leu His Leu Ala Val 
    130                 135                 140                 


Ala Asp Thr Leu Leu Val Leu Thr Leu Pro Leu Trp Ala Val Asp Ala 
145                 150                 155                 160 


Ala Val Gln Trp Val Phe Gly Ser Gly Leu Cys Lys Val Ala Gly Ala 
                165                 170                 175     


Leu Phe Asn Ile Asn Phe Tyr Ala Gly Ala Leu Leu Leu Ala Cys Ile 
            180                 185                 190         


Ser Phe Asp Arg Tyr Leu Asn Ile Val His Ala Thr Gln Leu Tyr Arg 
        195                 200                 205             


Arg Gly Pro Pro Ala Arg Val Thr Leu Thr Cys Leu Ala Val Trp Gly 
    210                 215                 220                 


Leu Cys Leu Leu Phe Ala Leu Pro Asp Phe Ile Phe Leu Ser Ala His 
225                 230                 235                 240 


His Asp Glu Arg Leu Asn Ala Thr His Cys Gln Tyr Asn Phe Pro Gln 
                245                 250                 255     


Val Gly Arg Thr Ala Leu Arg Val Leu Gln Leu Val Ala Gly Phe Leu 
            260                 265                 270         


Leu Pro Leu Leu Val Met Ala Tyr Cys Tyr Ala His Ile Leu Ala Val 
        275                 280                 285             


Leu Leu Val Ser Arg Gly Gln Arg Arg Leu Arg Ala Met Arg Leu Val 
    290                 295                 300                 


Val Val Val Val Val Ala Phe Ala Leu Cys Trp Thr Pro Tyr His Leu 
305                 310                 315                 320 


Val Val Leu Val Asp Ile Leu Met Asp Leu Gly Ala Leu Ala Arg Asn 
                325                 330                 335     


Cys Gly Arg Glu Ser Arg Val Asp Val Ala Lys Ser Val Thr Ser Gly 
            340                 345                 350         


Leu Gly Tyr Met His Cys Cys Leu Asn Pro Leu Leu Tyr Ala Phe Val 
        355                 360                 365             


Gly Val Lys Phe Arg Glu Arg Met Trp Met Leu Leu Leu Arg Leu Gly 
    370                 375                 380                 


Cys Pro Asn Gln Arg Gly Leu Gln Arg Gln Pro Ser Ser Ser Arg Arg 
385                 390                 395                 400 


Asp Ser Ser Trp Ser Glu Thr Ser Glu Ala Ser Tyr Ser Gly Leu 
                405                 410                 415 


<210>  406
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  406

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  407
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  407

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  408
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  408

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  409
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  409

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  410
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  410

Met Glu Ala Ala Val Ala Ala Pro Arg Pro Arg Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Leu Leu Pro Gly Ala Thr 
            20                  25                  30          


Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
        35                  40                  45              


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
    50                  55                  60                  


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
65                  70                  75                  80  


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
                85                  90                  95      


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro 
            100                 105                 110         


Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu Leu Ala Ala 
        115                 120                 125             


Val Ile Ala Gly Pro Val Cys Phe Val Cys Ile Ser Leu Met Leu Met 
    130                 135                 140                 


Val Tyr Ile Cys His Asn Arg Thr Val Ile His His Arg Val Pro Asn 
145                 150                 155                 160 


Glu Glu Asp Pro Ser Leu Asp Arg Pro Phe Ile Ser Glu Gly Thr Thr 
                165                 170                 175     


Leu Lys Asp Leu Ile Tyr Asp Met Thr Thr Ser Gly Ser Gly Ser Gly 
            180                 185                 190         


Leu Pro Leu Leu Val Gln Arg Thr Ile Ala Arg Thr Ile Val Leu Gln 
        195                 200                 205             


Glu Ser Ile Gly Lys Gly Arg Phe Gly Glu Val Trp Arg Gly Lys Trp 
    210                 215                 220                 


Arg Gly Glu Glu Val Ala Val Lys Ile Phe Ser Ser Arg Glu Glu Arg 
225                 230                 235                 240 


Ser Trp Phe Arg Glu Ala Glu Ile Tyr Gln Thr Val Met Leu Arg His 
                245                 250                 255     


Glu Asn Ile Leu Gly Phe Ile Ala Ala Asp Asn Lys Asp Asn Gly Thr 
            260                 265                 270         


Trp Thr Gln Leu Trp Leu Val Ser Asp Tyr His Glu His Gly Ser Leu 
        275                 280                 285             


Phe Asp Tyr Leu Asn Arg Tyr Thr Val Thr Val Glu Gly Met Ile Lys 
    290                 295                 300                 


Leu Ala Leu Ser Thr Ala Ser Gly Leu Ala His Leu His Met Glu Ile 
305                 310                 315                 320 


Val Gly Thr Gln Gly Lys Pro Ala Ile Ala His Arg Asp Leu Lys Ser 
                325                 330                 335     


Lys Asn Ile Leu Val Lys Lys Asn Gly Thr Cys Cys Ile Ala Asp Leu 
            340                 345                 350         


Gly Leu Ala Val Arg His Asp Ser Ala Thr Asp Thr Ile Asp Ile Ala 
        355                 360                 365             


Pro Asn His Arg Val Gly Thr Lys Arg Tyr Met Ala Pro Glu Val Leu 
    370                 375                 380                 


Asp Asp Ser Ile Asn Met Lys His Phe Glu Ser Phe Lys Arg Ala Asp 
385                 390                 395                 400 


Ile Tyr Ala Met Gly Leu Val Phe Trp Glu Ile Ala Arg Arg Cys Ser 
                405                 410                 415     


Ile Gly Gly Ile His Glu Asp Tyr Gln Leu Pro Tyr Tyr Asp Leu Val 
            420                 425                 430         


Pro Ser Asp Pro Ser Val Glu Glu Met Arg Lys Val Val Cys Glu Gln 
        435                 440                 445             


Lys Leu Arg Pro Asn Ile Pro Asn Arg Trp Gln Ser Cys Glu Ala Leu 
    450                 455                 460                 


Arg Val Met Ala Lys Ile Met Arg Glu Cys Trp Tyr Ala Asn Gly Ala 
465                 470                 475                 480 


Ala Arg Leu Thr Ala Leu Arg Ile Lys Lys Thr Leu Ser Gln Leu Ser 
                485                 490                 495     


Gln Gln Glu Gly Ile Lys Met 
            500             


<210>  411
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  411

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn 
            180                 185                 190         


Arg Gln Gln Lys Leu Ser Ser Thr Trp Glu Thr Gly Lys Thr Arg Lys 
        195                 200                 205             


Leu Met Glu Phe Ser Glu His Cys Ala Ile Ile Leu Glu Asp Asp Arg 
    210                 215                 220                 


Ser Asp Ile Ser Ser Thr Cys Ala Asn Asn Ile Asn His Asn Thr Glu 
225                 230                 235                 240 


Leu Leu Pro Ile Glu Leu Asp Thr Leu Val Gly Lys Gly Arg Phe Ala 
                245                 250                 255     


Glu Val Tyr Lys Ala Lys Leu Lys Gln Asn Thr Ser Glu Gln Phe Glu 
            260                 265                 270         


Thr Val Ala Val Lys Ile Phe Pro Tyr Glu Glu Tyr Ala Ser Trp Lys 
        275                 280                 285             


Thr Glu Lys Asp Ile Phe Ser Asp Ile Asn Leu Lys His Glu Asn Ile 
    290                 295                 300                 


Leu Gln Phe Leu Thr Ala Glu Glu Arg Lys Thr Glu Leu Gly Lys Gln 
305                 310                 315                 320 


Tyr Trp Leu Ile Thr Ala Phe His Ala Lys Gly Asn Leu Gln Glu Tyr 
                325                 330                 335     


Leu Thr Arg His Val Ile Ser Trp Glu Asp Leu Arg Lys Leu Gly Ser 
            340                 345                 350         


Ser Leu Ala Arg Gly Ile Ala His Leu His Ser Asp His Thr Pro Cys 
        355                 360                 365             


Gly Arg Pro Lys Met Pro Ile Val His Arg Asp Leu Lys Ser Ser Asn 
    370                 375                 380                 


Ile Leu Val Lys Asn Asp Leu Thr Cys Cys Leu Cys Asp Phe Gly Leu 
385                 390                 395                 400 


Ser Leu Arg Leu Asp Pro Thr Leu Ser Val Asp Asp Leu Ala Asn Ser 
                405                 410                 415     


Gly Gln Val Gly Thr Ala Arg Tyr Met Ala Pro Glu Val Leu Glu Ser 
            420                 425                 430         


Arg Met Asn Leu Glu Asn Val Glu Ser Phe Lys Gln Thr Asp Val Tyr 
        435                 440                 445             


Ser Met Ala Leu Val Leu Trp Glu Met Thr Ser Arg Cys Asn Ala Val 
    450                 455                 460                 


Gly Glu Val Lys Asp Tyr Glu Pro Pro Phe Gly Ser Lys Val Arg Glu 
465                 470                 475                 480 


His Pro Cys Val Glu Ser Met Lys Asp Asn Val Leu Arg Asp Arg Gly 
                485                 490                 495     


Arg Pro Glu Ile Pro Ser Phe Trp Leu Asn His Gln Gly Ile Gln Met 
            500                 505                 510         


Val Cys Glu Thr Leu Thr Glu Cys Trp Asp His Asp Pro Glu Ala Arg 
        515                 520                 525             


Leu Thr Ala Gln Cys Val Ala Glu Arg Phe Ser Glu Leu Glu His Leu 
    530                 535                 540                 


Asp Arg Leu Ser Gly Arg Ser Cys Ser Glu Glu Lys Ile Pro Glu Asp 
545                 550                 555                 560 


Gly Ser Leu Asn Thr Thr Lys 
                565         


<210>  412
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  412

Met Thr Ser His Tyr Val Ile Ala Ile Phe Ala Leu Met Ser Ser Cys 
1               5                   10                  15      


Leu Ala Thr Ala Gly Pro Glu Pro Gly Ala Leu Cys Glu Leu Ser Pro 
            20                  25                  30          


Val Ser Ala Ser His Pro Val Gln Ala Leu Met Glu Ser Phe Thr Val 
        35                  40                  45              


Leu Ser Gly Cys Ala Ser Arg Gly Thr Thr Gly Leu Pro Gln Glu Val 
    50                  55                  60                  


His Val Leu Asn Leu Arg Thr Ala Gly Gln Gly Pro Gly Gln Leu Gln 
65                  70                  75                  80  


Arg Glu Val Thr Leu His Leu Asn Pro Ile Ser Ser Val His Ile His 
                85                  90                  95      


His Lys Ser Val Val Phe Leu Leu Asn Ser Pro His Pro Leu Val Trp 
            100                 105                 110         


His Leu Lys Thr Glu Arg Leu Ala Thr Gly Val Ser Arg Leu Phe Leu 
        115                 120                 125             


Val Ser Glu Gly Ser Val Val Gln Phe Ser Ser Ala Asn Phe Ser Leu 
    130                 135                 140                 


Thr Ala Glu Thr Glu Glu Arg Asn Phe Pro His Gly Asn Glu His Leu 
145                 150                 155                 160 


Leu Asn Trp Ala Arg Lys Glu Tyr Gly Ala Val Thr Ser Phe Thr Glu 
                165                 170                 175     


Leu Lys Ile Ala Arg Asn Ile Tyr Ile Lys Val Gly Glu Asp Gln Val 
            180                 185                 190         


Phe Pro Pro Lys Cys Asn Ile Gly Lys Asn Phe Leu Ser Leu Asn Tyr 
        195                 200                 205             


Leu Ala Glu Tyr Leu Gln Pro Lys Ala Ala Glu Gly Cys Val Met Ser 
    210                 215                 220                 


Ser Gln Pro Gln Asn Glu Glu Val His Ile Ile Glu Leu Ile Thr Pro 
225                 230                 235                 240 


Asn Ser Asn Pro Tyr Ser Ala Phe Gln Val Asp Ile Thr Ile Asp Ile 
                245                 250                 255     


Arg Pro Ser Gln Glu Asp Leu Glu Val Val Lys Asn Leu Ile Leu Ile 
            260                 265                 270         


Leu Lys Cys Lys Lys Ser Val Asn Trp Val Ile Lys Ser Phe Asp Val 
        275                 280                 285             


Lys Gly Ser Leu Lys Ile Ile Ala Pro Asn Ser Ile Gly Phe Gly Lys 
    290                 295                 300                 


Glu Ser Glu Arg Ser Met Thr Met Thr Lys Ser Ile Arg Asp Asp Ile 
305                 310                 315                 320 


Pro Ser Thr Gln Gly Asn Leu Val Lys Trp Ala Leu Asp Asn Gly Tyr 
                325                 330                 335     


Ser Pro Ile Thr Ser Tyr Thr Met Ala Pro Val Ala Asn Arg Phe His 
            340                 345                 350         


Leu Arg Leu Glu Asn Asn Ala Glu Glu Met Gly Asp Glu Glu Val His 
        355                 360                 365             


Thr Ile Pro Pro Glu Leu Arg Ile Leu Leu Asp Pro Gly Ala Leu Pro 
    370                 375                 380                 


Ala Leu Gln Asn Pro Pro Ile Arg Gly Gly Glu Gly Gln Asn Gly Gly 
385                 390                 395                 400 


Leu Pro Phe Pro Phe Pro Asp Ile Ser Arg Arg Val Trp Asn Glu Glu 
                405                 410                 415     


Gly Glu Asp Gly Leu Pro Arg Pro Lys Asp Pro Val Ile Pro Ser Ile 
            420                 425                 430         


Gln Leu Phe Pro Gly Leu Arg Glu Pro Glu Glu Val Gln Gly Ser Val 
        435                 440                 445             


Asp Ile Ala Leu Ser Val Lys Cys Asp Asn Glu Lys Met Ile Val Ala 
    450                 455                 460                 


Val Glu Lys Asp Ser Phe Gln Ala Ser Gly Tyr Ser Gly Met Asp Val 
465                 470                 475                 480 


Thr Leu Leu Asp Pro Thr Cys Lys Ala Lys Met Asn Gly Thr His Phe 
                485                 490                 495     


Val Leu Glu Ser Pro Leu Asn Gly Cys Gly Thr Arg Pro Arg Trp Ser 
            500                 505                 510         


Ala Leu Asp Gly Val Val Tyr Tyr Asn Ser Ile Val Ile Gln Val Pro 
        515                 520                 525             


Ala Leu Gly Asp Ser Ser Gly Trp Pro Asp Gly Tyr Glu Asp Leu Glu 
    530                 535                 540                 


Ser Gly Asp Asn Gly Phe Pro Gly Asp Met Asp Glu Gly Asp Ala Ser 
545                 550                 555                 560 


Leu Phe Thr Arg Pro Glu Ile Val Val Phe Asn Cys Ser Leu Gln Gln 
                565                 570                 575     


Val Arg Asn Pro Ser Ser Phe Gln Glu Gln Pro His Gly Asn Ile Thr 
            580                 585                 590         


Phe Asn Met Glu Leu Tyr Asn Thr Asp Leu Phe Leu Val Pro Ser Gln 
        595                 600                 605             


Gly Val Phe Ser Val Pro Glu Asn Gly His Val Tyr Val Glu Val Ser 
    610                 615                 620                 


Val Thr Lys Ala Glu Gln Glu Leu Gly Phe Ala Ile Gln Thr Cys Phe 
625                 630                 635                 640 


Ile Ser Pro Tyr Ser Asn Pro Asp Arg Met Ser His Tyr Thr Ile Ile 
                645                 650                 655     


Glu Asn Ile Cys Pro Lys Asp Glu Ser Val Lys Phe Tyr Ser Pro Lys 
            660                 665                 670         


Arg Val His Phe Pro Ile Pro Gln Ala Asp Met Asp Lys Lys Arg Phe 
        675                 680                 685             


Ser Phe Val Phe Lys Pro Val Phe Asn Thr Ser Leu Leu Phe Leu Gln 
    690                 695                 700                 


Cys Glu Leu Thr Leu Cys Thr Lys Met Glu Lys His Pro Gln Lys Leu 
705                 710                 715                 720 


Pro Lys Cys Val Pro Pro Asp Glu Ala Cys Thr Ser Leu Asp Ala Ser 
                725                 730                 735     


Ile Ile Trp Ala Met Met Gln Asn Lys Lys Thr Phe Thr Lys Pro Leu 
            740                 745                 750         


Ala Val Ile His His Glu Ala Glu Ser Lys Glu Lys Gly Pro Ser Met 
        755                 760                 765             


Lys Glu Pro Asn Pro Ile Ser Pro Pro Ile Phe His Gly Leu Asp Thr 
    770                 775                 780                 


Leu Thr Val Met Gly Ile Ala Phe Ala Ala Phe Val Ile Gly Ala Leu 
785                 790                 795                 800 


Leu Thr Gly Ala Leu Trp Tyr Ile Tyr Ser His Thr Gly Glu Thr Ala 
                805                 810                 815     


Gly Arg Gln Gln Val Pro Thr Ser Pro Pro Ala Ser Glu Asn Ser Ser 
            820                 825                 830         


Ala Ala His Ser Ile Gly Ser Thr Gln Ser Thr Pro Cys Ser Ser Ser 
        835                 840                 845             


Ser Thr Ala 
    850     


<210>  413
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Gly Pro Ala Pro Leu Pro Leu Leu Leu Gly Leu Phe Leu Pro Ala 
1               5                   10                  15      


Leu Trp Arg Arg Ala Ile Thr Glu Ala Arg Glu Glu Ala Lys Pro Tyr 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Phe Pro Gly Ser Leu Gln Thr Asp His Thr 
        35                  40                  45              


Pro Leu Leu Ser Leu Pro His Ala Ser Gly Tyr Gln Pro Ala Leu Met 
    50                  55                  60                  


Phe Ser Pro Thr Gln Pro Gly Arg Pro His Thr Gly Asn Val Ala Ile 
65                  70                  75                  80  


Pro Gln Val Thr Ser Val Glu Ser Lys Pro Leu Pro Pro Leu Ala Phe 
                85                  90                  95      


Lys His Thr Val Gly His Ile Ile Leu Ser Glu His Lys Gly Val Lys 
            100                 105                 110         


Phe Asn Cys Ser Ile Ser Val Pro Asn Ile Tyr Gln Asp Thr Thr Ile 
        115                 120                 125             


Ser Trp Trp Lys Asp Gly Lys Glu Leu Leu Gly Ala His His Ala Ile 
    130                 135                 140                 


Thr Gln Phe Tyr Pro Asp Asp Glu Val Thr Ala Ile Ile Ala Ser Phe 
145                 150                 155                 160 


Ser Ile Thr Ser Val Gln Arg Ser Asp Asn Gly Ser Tyr Ile Cys Lys 
                165                 170                 175     


Met Lys Ile Asn Asn Glu Glu Ile Val Ser Asp Pro Ile Tyr Ile Glu 
            180                 185                 190         


Val Gln Gly Leu Pro His Phe Thr Lys Gln Pro Glu Ser Met Asn Val 
        195                 200                 205             


Thr Arg Asn Thr Ala Phe Asn Leu Thr Cys Gln Ala Val Gly Pro Pro 
    210                 215                 220                 


Glu Pro Val Asn Ile Phe Trp Val Gln Asn Ser Ser Arg Val Asn Glu 
225                 230                 235                 240 


Gln Pro Glu Lys Ser Pro Ser Val Leu Thr Val Pro Gly Leu Thr Glu 
                245                 250                 255     


Met Ala Val Phe Ser Cys Glu Ala His Asn Asp Lys Gly Leu Thr Val 
            260                 265                 270         


Ser Lys Gly Val Gln Ile Asn Ile Lys Ala Ile Pro Ser Pro Pro Thr 
        275                 280                 285             


Glu Val Ser Ile Arg Asn Ser Thr Ala His Ser Ile Leu Ile Ser Trp 
    290                 295                 300                 


Val Pro Gly Phe Asp Gly Tyr Ser Pro Phe Arg Asn Cys Ser Ile Gln 
305                 310                 315                 320 


Val Lys Glu Ala Asp Pro Leu Ser Asn Gly Ser Val Met Ile Phe Asn 
                325                 330                 335     


Thr Ser Ala Leu Pro His Leu Tyr Gln Ile Lys Gln Leu Gln Ala Leu 
            340                 345                 350         


Ala Asn Tyr Ser Ile Gly Val Ser Cys Met Asn Glu Ile Gly Trp Ser 
        355                 360                 365             


Ala Val Ser Pro Trp Ile Leu Ala Ser Thr Thr Glu Gly Ala Pro Ser 
    370                 375                 380                 


Val Ala Pro Leu Asn Val Thr Val Phe Leu Asn Glu Ser Ser Asp Asn 
385                 390                 395                 400 


Val Asp Ile Arg Trp Met Lys Pro Pro Thr Lys Gln Gln Asp Gly Glu 
                405                 410                 415     


Leu Val Gly Tyr Arg Ile Ser His Val Trp Gln Ser Ala Gly Ile Ser 
            420                 425                 430         


Lys Glu Leu Leu Glu Glu Val Gly Gln Asn Gly Ser Arg Ala Arg Ile 
        435                 440                 445             


Ser Val Gln Val His Asn Ala Thr Cys Thr Val Arg Ile Ala Ala Val 
    450                 455                 460                 


Thr Arg Gly Gly Val Gly Pro Phe Ser Asp Pro Val Lys Ile Phe Ile 
465                 470                 475                 480 


Pro Ala His Gly Trp Val Asp Tyr Ala Pro Ser Ser Thr Pro Ala Pro 
                485                 490                 495     


Gly Asn Ala Asp Pro Val Leu Ile Ile Phe Gly Cys Phe Cys Gly Phe 
            500                 505                 510         


Ile Leu Ile Gly Leu Ile Leu Tyr Ile Ser Leu Ala Ile Arg Lys Arg 
        515                 520                 525             


Val Gln Glu Thr Lys Phe Gly Asn Ala Phe Thr Glu Glu Asp Ser Glu 
    530                 535                 540                 


Leu Val Val Asn Tyr Ile Ala Lys Lys Ser Phe Cys Arg Arg Ala Ile 
545                 550                 555                 560 


Glu Leu Thr Leu His Ser Leu Gly Val Ser Glu Glu Leu Gln Asn Lys 
                565                 570                 575     


Leu Glu Asp Val Val Ile Asp Arg Asn Leu Leu Ile Leu Gly Lys Ile 
            580                 585                 590         


Leu Gly Glu Gly Glu Phe Gly Ser Val Met Glu Gly Asn Leu Lys Gln 
        595                 600                 605             


Glu Asp Gly Thr Ser Leu Lys Val Ala Val Lys Thr Met Lys Leu Asp 
    610                 615                 620                 


Asn Ser Ser Gln Arg Glu Ile Glu Glu Phe Leu Ser Glu Ala Ala Cys 
625                 630                 635                 640 


Met Lys Asp Phe Ser His Pro Asn Val Ile Arg Leu Leu Gly Val Cys 
                645                 650                 655     


Ile Glu Met Ser Ser Gln Gly Ile Pro Lys Pro Met Val Ile Leu Pro 
            660                 665                 670         


Phe Met Lys Tyr Gly Asp Leu His Thr Tyr Leu Leu Tyr Ser Arg Leu 
        675                 680                 685             


Glu Thr Gly Pro Lys His Ile Pro Leu Gln Thr Leu Leu Lys Phe Met 
    690                 695                 700                 


Val Asp Ile Ala Leu Gly Met Glu Tyr Leu Ser Asn Arg Asn Phe Leu 
705                 710                 715                 720 


His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Arg Asp Asp Met Thr 
                725                 730                 735     


Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Ser Gly Asp 
            740                 745                 750         


Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala 
        755                 760                 765             


Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp 
    770                 775                 780                 


Ala Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg Gly Met Thr Pro 
785                 790                 795                 800 


Tyr Pro Gly Val Gln Asn His Glu Met Tyr Asp Tyr Leu Leu His Gly 
                805                 810                 815     


His Arg Leu Lys Gln Pro Glu Asp Cys Leu Asp Glu Leu Tyr Glu Ile 
            820                 825                 830         


Met Tyr Ser Cys Trp Arg Thr Asp Pro Leu Asp Arg Pro Thr Phe Ser 
        835                 840                 845             


Val Leu Arg Leu Gln Leu Glu Lys Leu Leu Glu Ser Leu Pro Asp Val 
    850                 855                 860                 


Arg Asn Gln Ala Asp Val Ile Tyr Val Asn Thr Gln Leu Leu Glu Ser 
865                 870                 875                 880 


Ser Glu Gly Leu Ala Gln Gly Ser Thr Leu Ala Pro Leu Asp Leu Asn 
                885                 890                 895     


Ile Asp Pro Asp Ser Ile Ile Ala Ser Cys Thr Pro Arg Ala Ala Ile 
            900                 905                 910         


Ser Val Val Thr Ala Glu Val His Asp Ser Lys Pro His Glu Gly Arg 
        915                 920                 925             


Tyr Ile Leu Asn Gly Gly Ser Glu Glu Trp Glu Asp Leu Thr Ser Ala 
    930                 935                 940                 


Pro Ser Ala Ala Val Thr Ala Glu Lys Asn Ser Val Leu Pro Gly Glu 
945                 950                 955                 960 


Arg Leu Val Arg Asn Gly Val Ser Trp Ser His Ser Ser Met Leu Pro 
                965                 970                 975     


Leu Gly Ser Ser Leu Pro Asp Glu Leu Leu Phe Ala Asp Asp Ser Ser 
            980                 985                 990         


Glu Gly Ser Glu Val Leu Met 
        995                 


<210>  414
<211>  1489
<212>  PRT
<213>  Homo sapiens

<400>  414

Met Arg Gln Val Leu Trp Leu Cys Asn Val Cys Val Thr Ala Arg Glu 
1               5                   10                  15      


Thr Arg His His Leu His Leu Pro Ala Ile Leu Asp Lys Met Pro Ala 
            20                  25                  30          


Pro Gly Ala Leu Ile Leu Leu Ala Ala Val Ser Ala Ser Gly Cys Leu 
        35                  40                  45              


Ala Ser Pro Ala His Pro Asp Gly Phe Ala Leu Gly Arg Ala Pro Leu 
    50                  55                  60                  


Ala Pro Pro Tyr Ala Val Val Leu Ile Ser Cys Ser Gly Leu Leu Ala 
65                  70                  75                  80  


Phe Ile Phe Leu Leu Leu Thr Cys Leu Cys Cys Lys Arg Gly Asp Val 
                85                  90                  95      


Gly Phe Lys Glu Phe Glu Asn Pro Glu Gly Glu Asp Cys Ser Gly Glu 
            100                 105                 110         


Tyr Thr Pro Pro Ala Glu Glu Thr Ser Ser Ser Gln Ser Leu Pro Asp 
        115                 120                 125             


Val Tyr Ile Leu Pro Leu Ala Glu Val Ser Leu Pro Met Pro Ala Pro 
    130                 135                 140                 


Gln Pro Ser His Ser Asp Met Thr Thr Pro Leu Gly Leu Ser Arg Gln 
145                 150                 155                 160 


His Leu Ser Tyr Leu Gln Glu Ile Gly Ser Gly Trp Phe Gly Lys Val 
                165                 170                 175     


Ile Leu Gly Glu Ile Phe Ser Asp Tyr Thr Pro Ala Gln Val Val Val 
            180                 185                 190         


Lys Glu Leu Arg Ala Ser Ala Gly Pro Leu Glu Gln Arg Lys Phe Ile 
        195                 200                 205             


Ser Glu Ala Gln Pro Tyr Arg Ser Leu Gln His Pro Asn Val Leu Gln 
    210                 215                 220                 


Cys Leu Gly Leu Cys Val Glu Thr Leu Pro Phe Leu Leu Ile Met Glu 
225                 230                 235                 240 


Phe Cys Gln Leu Gly Asp Leu Lys Arg Tyr Leu Arg Ala Gln Arg Pro 
                245                 250                 255     


Pro Glu Gly Leu Ser Pro Glu Leu Pro Pro Arg Asp Leu Arg Thr Leu 
            260                 265                 270         


Gln Arg Met Gly Leu Glu Ile Ala Arg Gly Leu Ala His Leu His Ser 
        275                 280                 285             


His Asn Tyr Val His Ser Asp Leu Ala Leu Arg Asn Cys Leu Leu Thr 
    290                 295                 300                 


Ser Asp Leu Thr Val Arg Ile Gly Asp Tyr Gly Leu Ala His Ser Asn 
305                 310                 315                 320 


Tyr Lys Glu Asp Tyr Tyr Leu Thr Pro Glu Arg Leu Trp Ile Pro Leu 
                325                 330                 335     


Arg Trp Ala Ala Pro Glu Leu Leu Gly Glu Leu His Gly Thr Phe Met 
            340                 345                 350         


Val Val Asp Gln Ser Arg Glu Ser Asn Ile Trp Ser Leu Gly Val Thr 
        355                 360                 365             


Leu Trp Glu Leu Phe Glu Phe Gly Ala Gln Pro Tyr Arg His Leu Ser 
    370                 375                 380                 


Asp Glu Glu Val Leu Ala Phe Val Val Arg Gln Gln His Val Lys Leu 
385                 390                 395                 400 


Ala Arg Pro Arg Leu Lys Leu Pro Tyr Ala Asp Tyr Trp Tyr Asp Ile 
                405                 410                 415     


Leu Gln Ser Cys Trp Arg Pro Pro Ala Gln Arg Pro Ser Ala Ser Asp 
            420                 425                 430         


Leu Gln Leu Gln Leu Thr Tyr Leu Leu Ser Glu Arg Pro Pro Arg Pro 
        435                 440                 445             


Pro Pro Pro Pro Pro Pro Pro Arg Asp Gly Pro Phe Pro Trp Pro Trp 
    450                 455                 460                 


Pro Pro Ala His Ser Ala Pro Arg Pro Gly Thr Leu Ser Ser Pro Phe 
465                 470                 475                 480 


Pro Leu Leu Asp Gly Phe Pro Gly Ala Asp Pro Asp Asp Val Leu Thr 
                485                 490                 495     


Val Thr Glu Ser Ser Arg Gly Leu Asn Leu Glu Cys Leu Trp Glu Lys 
            500                 505                 510         


Ala Arg Arg Gly Ala Gly Arg Gly Gly Gly Ala Pro Ala Trp Gln Pro 
        515                 520                 525             


Ala Ser Ala Pro Pro Ala Pro His Ala Asn Pro Ser Asn Pro Phe Tyr 
    530                 535                 540                 


Glu Ala Leu Ser Thr Pro Ser Val Leu Pro Val Ile Ser Ala Arg Ser 
545                 550                 555                 560 


Pro Ser Val Ser Ser Glu Tyr Tyr Ile Arg Leu Glu Glu His Gly Ser 
                565                 570                 575     


Pro Pro Glu Pro Leu Phe Pro Asn Asp Trp Asp Pro Leu Asp Pro Gly 
            580                 585                 590         


Val Pro Ala Pro Gln Ala Pro Gln Ala Pro Ser Glu Val Pro Gln Leu 
        595                 600                 605             


Val Ser Glu Thr Trp Ala Ser Pro Leu Phe Pro Ala Pro Arg Pro Phe 
    610                 615                 620                 


Pro Ala Gln Ser Ser Ala Ser Gly Ser Phe Leu Leu Ser Gly Trp Asp 
625                 630                 635                 640 


Pro Glu Gly Arg Gly Ala Gly Glu Thr Leu Ala Gly Asp Pro Ala Glu 
                645                 650                 655     


Val Leu Gly Glu Arg Gly Thr Ala Pro Trp Val Glu Glu Glu Glu Glu 
            660                 665                 670         


Glu Glu Glu Gly Ser Ser Pro Gly Glu Asp Ser Ser Ser Leu Gly Gly 
        675                 680                 685             


Gly Pro Ser Arg Arg Gly Pro Leu Pro Cys Pro Leu Cys Ser Arg Glu 
    690                 695                 700                 


Gly Ala Cys Ser Cys Leu Pro Leu Glu Arg Gly Asp Ala Val Ala Gly 
705                 710                 715                 720 


Trp Gly Gly His Pro Ala Leu Gly Cys Pro His Pro Pro Glu Asp Asp 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Arg Gly Ser Leu Ala Asp Leu Pro Met Ala 
            740                 745                 750         


Pro Pro Ala Ser Ala Pro Pro Glu Phe Leu Asp Pro Leu Met Gly Ala 
        755                 760                 765             


Ala Ala Pro Gln Tyr Pro Gly Arg Gly Pro Pro Pro Ala Pro Pro Pro 
    770                 775                 780                 


Pro Pro Pro Pro Pro Arg Ala Pro Ala Asp Pro Ala Ala Ser Pro Asp 
785                 790                 795                 800 


Pro Pro Ser Ala Val Ala Ser Pro Gly Ser Gly Leu Ser Ser Pro Gly 
                805                 810                 815     


Pro Lys Pro Gly Asp Ser Gly Tyr Glu Thr Glu Thr Pro Phe Ser Pro 
            820                 825                 830         


Glu Gly Ala Phe Pro Gly Gly Gly Ala Ala Glu Glu Glu Gly Val Pro 
        835                 840                 845             


Arg Pro Arg Ala Pro Pro Glu Pro Pro Asp Pro Gly Ala Pro Arg Pro 
    850                 855                 860                 


Pro Pro Asp Pro Gly Pro Leu Pro Leu Pro Gly Pro Arg Glu Lys Pro 
865                 870                 875                 880 


Thr Phe Val Val Gln Val Ser Thr Glu Gln Leu Leu Met Ser Leu Arg 
                885                 890                 895     


Glu Asp Val Thr Arg Asn Leu Leu Gly Glu Lys Gly Ala Thr Ala Arg 
            900                 905                 910         


Glu Thr Gly Pro Arg Lys Ala Gly Arg Gly Pro Gly Asn Arg Glu Lys 
        915                 920                 925             


Val Pro Gly Leu Asn Arg Asp Pro Thr Val Leu Gly Asn Gly Lys Gln 
    930                 935                 940                 


Ala Pro Ser Leu Ser Leu Pro Val Asn Gly Val Thr Val Leu Glu Asn 
945                 950                 955                 960 


Gly Asp Gln Arg Ala Pro Gly Ile Glu Glu Lys Ala Ala Glu Asn Gly 
                965                 970                 975     


Ala Leu Gly Ser Pro Glu Arg Glu Glu Lys Val Leu Glu Asn Gly Glu 
            980                 985                 990         


Leu Thr Pro Pro Arg Arg Glu Glu  Lys Ala Leu Glu Asn  Gly Glu Leu 
        995                 1000                 1005             


Arg Ser  Pro Glu Ala Gly Glu  Lys Val Leu Val Asn  Gly Gly Leu 
    1010                 1015                 1020             


Thr Pro  Pro Lys Ser Glu Asp  Lys Val Ser Glu Asn  Gly Gly Leu 
    1025                 1030                 1035             


Arg Phe  Pro Arg Asn Thr Glu  Arg Pro Pro Glu Thr  Gly Pro Trp 
    1040                 1045                 1050             


Arg Ala  Pro Gly Pro Trp Glu  Lys Thr Pro Glu Ser  Trp Gly Pro 
    1055                 1060                 1065             


Ala Pro  Thr Ile Gly Glu Pro  Ala Pro Glu Thr Ser  Leu Glu Arg 
    1070                 1075                 1080             


Ala Pro  Ala Pro Ser Ala Val  Val Ser Ser Arg Asn  Gly Gly Glu 
    1085                 1090                 1095             


Thr Ala  Pro Gly Pro Leu Gly  Pro Ala Pro Lys Asn  Gly Thr Leu 
    1100                 1105                 1110             


Glu Pro  Gly Thr Glu Arg Arg  Ala Pro Glu Thr Gly  Gly Ala Pro 
    1115                 1120                 1125             


Arg Ala  Pro Gly Ala Gly Arg  Leu Asp Leu Gly Ser  Gly Gly Arg 
    1130                 1135                 1140             


Ala Pro  Val Gly Thr Gly Thr  Ala Pro Gly Gly Gly  Pro Gly Ser 
    1145                 1150                 1155             


Gly Val  Asp Ala Lys Ala Gly  Trp Val Asp Asn Thr  Arg Pro Gln 
    1160                 1165                 1170             


Pro Pro  Pro Pro Pro Leu Pro  Pro Pro Pro Glu Ala  Gln Pro Arg 
    1175                 1180                 1185             


Arg Leu  Glu Pro Ala Pro Pro  Arg Ala Arg Pro Glu  Val Ala Pro 
    1190                 1195                 1200             


Glu Gly  Glu Pro Gly Ala Pro  Asp Ser Arg Ala Gly  Gly Asp Thr 
    1205                 1210                 1215             


Ala Leu  Ser Gly Asp Gly Asp  Pro Pro Lys Pro Glu  Arg Lys Gly 
    1220                 1225                 1230             


Pro Glu  Met Pro Arg Leu Phe  Leu Asp Leu Gly Pro  Pro Gln Gly 
    1235                 1240                 1245             


Asn Ser  Glu Gln Ile Lys Ala  Arg Leu Ser Arg Leu  Ser Leu Ala 
    1250                 1255                 1260             


Leu Pro  Pro Leu Thr Leu Thr  Pro Phe Pro Gly Pro  Gly Pro Arg 
    1265                 1270                 1275             


Arg Pro  Pro Trp Glu Gly Ala  Asp Ala Gly Ala Ala  Gly Gly Glu 
    1280                 1285                 1290             


Ala Gly  Gly Ala Gly Ala Pro  Gly Pro Ala Glu Glu  Asp Gly Glu 
    1295                 1300                 1305             


Asp Glu  Asp Glu Asp Glu Glu  Glu Asp Glu Glu Ala  Ala Ala Pro 
    1310                 1315                 1320             


Gly Ala  Ala Ala Gly Pro Arg  Gly Pro Gly Arg Ala  Arg Ala Ala 
    1325                 1330                 1335             


Pro Val  Pro Val Val Val Ser  Ser Ala Asp Ala Asp  Ala Ala Arg 
    1340                 1345                 1350             


Pro Leu  Arg Gly Leu Leu Lys  Ser Pro Arg Gly Ala  Asp Glu Pro 
    1355                 1360                 1365             


Glu Asp  Ser Glu Leu Glu Arg  Lys Arg Lys Met Val  Ser Phe His 
    1370                 1375                 1380             


Gly Asp  Val Thr Val Tyr Leu  Phe Asp Gln Glu Thr  Pro Thr Asn 
    1385                 1390                 1395             


Glu Leu  Ser Val Gln Ala Pro  Pro Glu Gly Asp Thr  Asp Pro Ser 
    1400                 1405                 1410             


Thr Pro  Pro Ala Pro Pro Thr  Pro Pro His Pro Ala  Thr Pro Gly 
    1415                 1420                 1425             


Asp Gly  Phe Pro Ser Asn Asp  Ser Gly Phe Gly Gly  Ser Phe Glu 
    1430                 1435                 1440             


Trp Ala  Glu Asp Phe Pro Leu  Leu Pro Pro Pro Gly  Pro Pro Leu 
    1445                 1450                 1455             


Cys Phe  Ser Arg Phe Ser Val  Ser Pro Ala Leu Glu  Thr Pro Gly 
    1460                 1465                 1470             


Pro Pro  Ala Arg Ala Pro Asp  Ala Arg Pro Ala Gly  Pro Val Glu 
    1475                 1480                 1485             


Asn 
    


<210>  415
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Gly Pro Gly Val Leu Leu Leu Leu Leu Val Ala Thr Ala Trp His 
1               5                   10                  15      


Gly Gln Gly Ile Pro Val Ile Glu Pro Ser Val Pro Glu Leu Val Val 
            20                  25                  30          


Lys Pro Gly Ala Thr Val Thr Leu Arg Cys Val Gly Asn Gly Ser Val 
        35                  40                  45              


Glu Trp Asp Gly Pro Pro Ser Pro His Trp Thr Leu Tyr Ser Asp Gly 
    50                  55                  60                  


Ser Ser Ser Ile Leu Ser Thr Asn Asn Ala Thr Phe Gln Asn Thr Gly 
65                  70                  75                  80  


Thr Tyr Arg Cys Thr Glu Pro Gly Asp Pro Leu Gly Gly Ser Ala Ala 
                85                  90                  95      


Ile His Leu Tyr Val Lys Asp Pro Ala Arg Pro Trp Asn Val Leu Ala 
            100                 105                 110         


Gln Glu Val Val Val Phe Glu Asp Gln Asp Ala Leu Leu Pro Cys Leu 
        115                 120                 125             


Leu Thr Asp Pro Val Leu Glu Ala Gly Val Ser Leu Val Arg Val Arg 
    130                 135                 140                 


Gly Arg Pro Leu Met Arg His Thr Asn Tyr Ser Phe Ser Pro Trp His 
145                 150                 155                 160 


Gly Phe Thr Ile His Arg Ala Lys Phe Ile Gln Ser Gln Asp Tyr Gln 
                165                 170                 175     


Cys Ser Ala Leu Met Gly Gly Arg Lys Val Met Ser Ile Ser Ile Arg 
            180                 185                 190         


Leu Lys Val Gln Lys Val Ile Pro Gly Pro Pro Ala Leu Thr Leu Val 
        195                 200                 205             


Pro Ala Glu Leu Val Arg Ile Arg Gly Glu Ala Ala Gln Ile Val Cys 
    210                 215                 220                 


Ser Ala Ser Ser Val Asp Val Asn Phe Asp Val Phe Leu Gln His Asn 
225                 230                 235                 240 


Asn Thr Lys Leu Ala Ile Pro Gln Gln Ser Asp Phe His Asn Asn Arg 
                245                 250                 255     


Tyr Gln Lys Val Leu Thr Leu Asn Leu Asp Gln Val Asp Phe Gln His 
            260                 265                 270         


Ala Gly Asn Tyr Ser Cys Val Ala Ser Asn Val Gln Gly Lys His Ser 
        275                 280                 285             


Thr Ser Met Phe Phe Arg Val Val Glu Ser Ala Tyr Leu Asn Leu Ser 
    290                 295                 300                 


Ser Glu Gln Asn Leu Ile Gln Glu Val Thr Val Gly Glu Gly Leu Asn 
305                 310                 315                 320 


Leu Lys Val Met Val Glu Ala Tyr Pro Gly Leu Gln Gly Phe Asn Trp 
                325                 330                 335     


Thr Tyr Leu Gly Pro Phe Ser Asp His Gln Pro Glu Pro Lys Leu Ala 
            340                 345                 350         


Asn Ala Thr Thr Lys Asp Thr Tyr Arg His Thr Phe Thr Leu Ser Leu 
        355                 360                 365             


Pro Arg Leu Lys Pro Ser Glu Ala Gly Arg Tyr Ser Phe Leu Ala Arg 
    370                 375                 380                 


Asn Pro Gly Gly Trp Arg Ala Leu Thr Phe Glu Leu Thr Leu Arg Tyr 
385                 390                 395                 400 


Pro Pro Glu Val Ser Val Ile Trp Thr Phe Ile Asn Gly Ser Gly Thr 
                405                 410                 415     


Leu Leu Cys Ala Ala Ser Gly Tyr Pro Gln Pro Asn Val Thr Trp Leu 
            420                 425                 430         


Gln Cys Ser Gly His Thr Asp Arg Cys Asp Glu Ala Gln Val Leu Gln 
        435                 440                 445             


Val Trp Asp Asp Pro Tyr Pro Glu Val Leu Ser Gln Glu Pro Phe His 
    450                 455                 460                 


Lys Val Thr Val Gln Ser Leu Leu Thr Val Glu Thr Leu Glu His Asn 
465                 470                 475                 480 


Gln Thr Tyr Glu Cys Arg Ala His Asn Ser Val Gly Ser Gly Ser Trp 
                485                 490                 495     


Ala Phe Ile Pro Ile Ser Ala Gly Ala His Thr His Pro Pro Asp Glu 
            500                 505                 510         


Phe Leu Phe Thr Pro Val Val Val Ala Cys Met Ser Ile Met Ala Leu 
        515                 520                 525             


Leu Leu Leu Leu Leu Leu Leu Leu Leu Tyr Lys Tyr Lys Gln Lys Pro 
    530                 535                 540                 


Lys Tyr Gln Val Arg Trp Lys Ile Ile Glu Ser Tyr Glu Gly Asn Ser 
545                 550                 555                 560 


Tyr Thr Phe Ile Asp Pro Thr Gln Leu Pro Tyr Asn Glu Lys Trp Glu 
                565                 570                 575     


Phe Pro Arg Asn Asn Leu Gln Phe Gly Lys Thr Leu Gly Ala Gly Ala 
            580                 585                 590         


Phe Gly Lys Val Val Glu Ala Thr Ala Phe Gly Leu Gly Lys Glu Asp 
        595                 600                 605             


Ala Val Leu Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala His Ala 
    610                 615                 620                 


Asp Glu Lys Glu Ala Leu Met Ser Glu Leu Lys Ile Met Ser His Leu 
625                 630                 635                 640 


Gly Gln His Glu Asn Ile Val Asn Leu Leu Gly Ala Cys Thr His Gly 
                645                 650                 655     


Gly Pro Val Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly Asp Leu Leu 
            660                 665                 670         


Asn Phe Leu Arg Arg Lys Ala Glu Ala Met Leu Gly Pro Ser Leu Ser 
        675                 680                 685             


Pro Gly Gln Asp Pro Glu Gly Gly Val Asp Tyr Lys Asn Ile His Leu 
    690                 695                 700                 


Glu Lys Lys Tyr Val Arg Arg Asp Ser Gly Phe Ser Ser Gln Gly Val 
705                 710                 715                 720 


Asp Thr Tyr Val Glu Met Arg Pro Val Ser Thr Ser Ser Asn Asp Ser 
                725                 730                 735     


Phe Ser Glu Gln Asp Leu Asp Lys Glu Asp Gly Arg Pro Leu Glu Leu 
            740                 745                 750         


Arg Asp Leu Leu His Phe Ser Ser Gln Val Ala Gln Gly Met Ala Phe 
        755                 760                 765             


Leu Ala Ser Lys Asn Cys Ile His Arg Asp Val Ala Ala Arg Asn Val 
    770                 775                 780                 


Leu Leu Thr Asn Gly His Val Ala Lys Ile Gly Asp Phe Gly Leu Ala 
785                 790                 795                 800 


Arg Asp Ile Met Asn Asp Ser Asn Tyr Ile Val Lys Gly Asn Ala Arg 
                805                 810                 815     


Leu Pro Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asp Cys Val Tyr 
            820                 825                 830         


Thr Val Gln Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu Ile 
        835                 840                 845             


Phe Ser Leu Gly Leu Asn Pro Tyr Pro Gly Ile Leu Val Asn Ser Lys 
    850                 855                 860                 


Phe Tyr Lys Leu Val Lys Asp Gly Tyr Gln Met Ala Gln Pro Ala Phe 
865                 870                 875                 880 


Ala Pro Lys Asn Ile Tyr Ser Ile Met Gln Ala Cys Trp Ala Leu Glu 
                885                 890                 895     


Pro Thr His Arg Pro Thr Phe Gln Gln Ile Cys Ser Phe Leu Gln Glu 
            900                 905                 910         


Gln Ala Gln Glu Asp Arg Arg Glu Arg Asp Tyr Thr Asn Leu Pro Ser 
        915                 920                 925             


Ser Ser Arg Ser Gly Gly Ser Gly Ser Ser Ser Ser Glu Leu Glu Glu 
    930                 935                 940                 


Glu Ser Ser Ser Glu His Leu Thr Cys Cys Glu Gln Gly Asp Ile Ala 
945                 950                 955                 960 


Gln Pro Leu Leu Gln Pro Asn Asn Tyr Gln Phe Cys 
                965                 970         


<210>  416
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  416

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  417
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  417

Met Glu Leu Gln Ala Ala Arg Ala Cys Phe Ala Leu Leu Trp Gly Cys 
1               5                   10                  15      


Ala Leu Ala Ala Ala Ala Ala Ala Gln Gly Lys Glu Val Val Leu Leu 
            20                  25                  30          


Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly Trp Leu Thr His Pro Tyr 
        35                  40                  45              


Gly Lys Gly Trp Asp Leu Met Gln Asn Ile Met Asn Asp Met Pro Ile 
    50                  55                  60                  


Tyr Met Tyr Ser Val Cys Asn Val Met Ser Gly Asp Gln Asp Asn Trp 
65                  70                  75                  80  


Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu Ala Glu Arg Ile Phe Ile 
                85                  90                  95      


Glu Leu Lys Phe Thr Val Arg Asp Cys Asn Ser Phe Pro Gly Gly Ala 
            100                 105                 110         


Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Ala Glu Ser Asp Leu 
        115                 120                 125             


Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu Phe Thr Lys Ile Asp Thr 
    130                 135                 140                 


Ile Ala Pro Asp Glu Ile Thr Val Ser Ser Asp Phe Glu Ala Arg His 
145                 150                 155                 160 


Val Lys Leu Asn Val Glu Glu Arg Ser Val Gly Pro Leu Thr Arg Lys 
                165                 170                 175     


Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Val Ala Leu Leu 
            180                 185                 190         


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Glu Leu Leu Gln Gly Leu 
        195                 200                 205             


Ala His Phe Pro Glu Thr Ile Ala Gly Ser Asp Ala Pro Ser Leu Ala 
    210                 215                 220                 


Thr Val Ala Gly Thr Cys Val Asp His Ala Val Val Pro Pro Gly Gly 
225                 230                 235                 240 


Glu Glu Pro Arg Met His Cys Ala Val Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr Glu Lys Val Glu Asp Ala 
            260                 265                 270         


Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys Phe Glu Ala Ser Glu Ser 
        275                 280                 285             


Pro Cys Leu Glu Cys Pro Glu His Thr Leu Pro Ser Pro Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe Arg Ala Pro Gln Asp Pro 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro His Tyr Leu Thr 
                325                 330                 335     


Ala Val Gly Met Gly Ala Lys Val Glu Leu Arg Trp Thr Pro Pro Gln 
            340                 345                 350         


Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr Ser Val Thr Cys Glu Gln 
        355                 360                 365             


Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro Cys Glu Ala Ser Val Arg 
    370                 375                 380                 


Tyr Ser Glu Pro Pro His Gly Leu Thr Arg Thr Ser Val Thr Val Ser 
385                 390                 395                 400 


Asp Leu Glu Pro His Met Asn Tyr Thr Phe Thr Val Glu Ala Arg Asn 
                405                 410                 415     


Gly Val Ser Gly Leu Val Thr Ser Arg Ser Phe Arg Thr Ala Ser Val 
            420                 425                 430         


Ser Ile Asn Gln Thr Glu Pro Pro Lys Val Arg Leu Glu Gly Arg Ser 
        435                 440                 445             


Thr Thr Ser Leu Ser Val Ser Trp Ser Ile Pro Pro Pro Gln Gln Ser 
    450                 455                 460                 


Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg Lys Lys Gly Asp Ser Asn 
465                 470                 475                 480 


Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe Ser Val Thr Leu Asp Asp 
                485                 490                 495     


Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln Val Gln Ala Leu Thr Gln 
            500                 505                 510         


Glu Gly Gln Gly Ala Gly Ser Lys Val His Glu Phe Gln Thr Leu Ser 
        515                 520                 525             


Pro Glu Gly Ser Gly Asn Leu Ala Val Ile Gly Gly Val Ala Val Gly 
    530                 535                 540                 


Val Val Leu Leu Leu Val Leu Ala Gly Val Gly Phe Phe Ile His Arg 
545                 550                 555                 560 


Arg Arg Lys Asn Gln Arg Ala Arg Gln Ser Pro Glu Asp Val Tyr Phe 
                565                 570                 575     


Ser Lys Ser Glu Gln Leu Lys Pro Leu Lys Thr Tyr Val Asp Pro His 
            580                 585                 590         


Thr Tyr Glu Asp Pro Asn Gln Ala Val Leu Lys Phe Thr Thr Glu Ile 
        595                 600                 605             


His Pro Ser Cys Val Thr Arg Gln Lys Val Ile Gly Ala Gly Glu Phe 
    610                 615                 620                 


Gly Glu Val Tyr Lys Gly Met Leu Lys Thr Ser Ser Gly Lys Lys Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile Lys Thr Leu Lys Ala Gly Tyr Thr Glu Lys Gln 
                645                 650                 655     


Arg Val Asp Phe Leu Gly Glu Ala Gly Ile Met Gly Gln Phe Ser His 
            660                 665                 670         


His Asn Ile Ile Arg Leu Glu Gly Val Ile Ser Lys Tyr Lys Pro Met 
        675                 680                 685             


Met Ile Ile Thr Glu Tyr Met Glu Asn Gly Ala Leu Asp Lys Phe Leu 
    690                 695                 700                 


Arg Glu Lys Asp Gly Glu Phe Ser Val Leu Gln Leu Val Gly Met Leu 
705                 710                 715                 720 


Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala Asn Met Asn Tyr Val 
                725                 730                 735     


His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu Val 
            740                 745                 750         


Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro 
        755                 760                 765             


Glu Ala Thr Tyr Thr Thr Ser Gly Gly Lys Ile Pro Ile Arg Trp Thr 
    770                 775                 780                 


Ala Pro Glu Ala Ile Ser Tyr Arg Lys Phe Thr Ser Ala Ser Asp Val 
785                 790                 795                 800 


Trp Ser Phe Gly Ile Val Met Trp Glu Val Met Thr Tyr Gly Glu Arg 
                805                 810                 815     


Pro Tyr Trp Glu Leu Ser Asn His Glu Val Met Lys Ala Ile Asn Asp 
            820                 825                 830         


Gly Phe Arg Leu Pro Thr Pro Met Asp Cys Pro Ser Ala Ile Tyr Gln 
        835                 840                 845             


Leu Met Met Gln Cys Trp Gln Gln Glu Arg Ala Arg Arg Pro Lys Phe 
    850                 855                 860                 


Ala Asp Ile Val Ser Ile Leu Asp Lys Leu Ile Arg Ala Pro Asp Ser 
865                 870                 875                 880 


Leu Lys Thr Leu Ala Asp Phe Asp Pro Arg Val Ser Ile Arg Leu Pro 
                885                 890                 895     


Ser Thr Ser Gly Ser Glu Gly Val Pro Phe Arg Thr Val Ser Glu Trp 
            900                 905                 910         


Leu Glu Ser Ile Lys Met Gln Gln Tyr Thr Glu His Phe Met Ala Ala 
        915                 920                 925             


Gly Tyr Thr Ala Ile Glu Lys Val Val Gln Met Thr Asn Asp Asp Ile 
    930                 935                 940                 


Lys Arg Ile Gly Val Arg Leu Pro Gly His Gln Lys Arg Ile Ala Tyr 
945                 950                 955                 960 


Ser Leu Leu Gly Leu Lys Asp Gln Val Asn Thr Val Gly Ile Pro Ile 
                965                 970                 975     


<210>  418
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  418

Met Glu Arg Arg Trp Pro Leu Gly Leu Gly Leu Val Leu Leu Leu Cys 
1               5                   10                  15      


Ala Pro Leu Pro Pro Gly Ala Arg Ala Lys Glu Val Thr Leu Met Asp 
            20                  25                  30          


Thr Ser Lys Ala Gln Gly Glu Leu Gly Trp Leu Leu Asp Pro Pro Lys 
        35                  40                  45              


Asp Gly Trp Ser Glu Gln Gln Gln Ile Leu Asn Gly Thr Pro Leu Tyr 
    50                  55                  60                  


Met Tyr Gln Asp Cys Pro Met Gln Gly Arg Arg Asp Thr Asp His Trp 
65                  70                  75                  80  


Leu Arg Ser Asn Trp Ile Tyr Arg Gly Glu Glu Ala Ser Arg Val His 
                85                  90                  95      


Val Glu Leu Gln Phe Thr Val Arg Asp Cys Lys Ser Phe Pro Gly Gly 
            100                 105                 110         


Ala Gly Pro Leu Gly Cys Lys Glu Thr Phe Asn Leu Leu Tyr Met Glu 
        115                 120                 125             


Ser Asp Gln Asp Val Gly Ile Gln Leu Arg Arg Pro Leu Phe Gln Lys 
    130                 135                 140                 


Val Thr Thr Val Ala Ala Asp Gln Ser Phe Thr Ile Arg Asp Leu Val 
145                 150                 155                 160 


Ser Gly Ser Val Lys Leu Asn Val Glu Arg Cys Ser Leu Gly Arg Leu 
                165                 170                 175     


Thr Arg Arg Gly Leu Tyr Leu Ala Phe His Asn Pro Gly Ala Cys Val 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Gln Arg Cys Pro Glu Thr Leu 
        195                 200                 205             


Asn Gly Leu Ala Gln Phe Pro Asp Thr Leu Pro Gly Pro Ala Gly Leu 
    210                 215                 220                 


Val Glu Val Ala Gly Thr Cys Leu Pro His Ala Arg Ala Ser Pro Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Pro Arg Met His Cys Ser Pro Asp Gly Glu Trp Leu 
                245                 250                 255     


Val Pro Val Gly Arg Cys His Cys Glu Pro Gly Tyr Glu Glu Gly Gly 
            260                 265                 270         


Ser Gly Glu Ala Cys Val Ala Cys Pro Ser Gly Ser Tyr Arg Met Asp 
        275                 280                 285             


Met Asp Thr Pro His Cys Leu Thr Cys Pro Gln Gln Ser Thr Ala Glu 
    290                 295                 300                 


Ser Glu Gly Ala Thr Ile Cys Thr Cys Glu Ser Gly His Tyr Arg Ala 
305                 310                 315                 320 


Pro Gly Glu Gly Pro Gln Val Ala Cys Thr Gly Pro Pro Ser Ala Pro 
                325                 330                 335     


Arg Asn Leu Ser Phe Ser Ala Ser Gly Thr Gln Leu Ser Leu Arg Trp 
            340                 345                 350         


Glu Pro Pro Ala Asp Thr Gly Gly Arg Gln Asp Val Arg Tyr Ser Val 
        355                 360                 365             


Arg Cys Ser Gln Cys Gln Gly Thr Ala Gln Asp Gly Gly Pro Cys Gln 
    370                 375                 380                 


Pro Cys Gly Val Gly Val His Phe Ser Pro Gly Ala Arg Gly Leu Thr 
385                 390                 395                 400 


Thr Pro Ala Val His Val Asn Gly Leu Glu Pro Tyr Ala Asn Tyr Thr 
                405                 410                 415     


Phe Asn Val Glu Ala Gln Asn Gly Val Ser Gly Leu Gly Ser Ser Gly 
            420                 425                 430         


His Ala Ser Thr Ser Val Ser Ile Ser Met Gly His Ala Glu Ser Leu 
        435                 440                 445             


Ser Gly Leu Ser Leu Arg Leu Val Lys Lys Glu Pro Arg Gln Leu Glu 
    450                 455                 460                 


Leu Thr Trp Ala Gly Ser Arg Pro Arg Ser Pro Gly Ala Asn Leu Thr 
465                 470                 475                 480 


Tyr Glu Leu His Val Leu Asn Gln Asp Glu Glu Arg Tyr Gln Met Val 
                485                 490                 495     


Leu Glu Pro Arg Val Leu Leu Thr Glu Leu Gln Pro Asp Thr Thr Tyr 
            500                 505                 510         


Ile Val Arg Val Arg Met Leu Thr Pro Leu Gly Pro Gly Pro Phe Ser 
        515                 520                 525             


Pro Asp His Glu Phe Arg Thr Ser Pro Pro Val Ser Arg Gly Leu Thr 
    530                 535                 540                 


Gly Gly Glu Ile Val Ala Val Ile Phe Gly Leu Leu Leu Gly Ala Ala 
545                 550                 555                 560 


Leu Leu Leu Gly Ile Leu Val Phe Arg Ser Arg Arg Ala Gln Arg Gln 
                565                 570                 575     


Arg Gln Gln Arg Gln Arg Asp Arg Ala Thr Asp Val Asp Arg Glu Asp 
            580                 585                 590         


Lys Leu Trp Leu Lys Pro Tyr Val Asp Leu Gln Ala Tyr Glu Asp Pro 
        595                 600                 605             


Ala Gln Gly Ala Leu Asp Phe Thr Arg Glu Leu Asp Pro Ala Trp Leu 
    610                 615                 620                 


Met Val Asp Thr Val Ile Gly Glu Gly Glu Phe Gly Glu Val Tyr Arg 
625                 630                 635                 640 


Gly Thr Leu Arg Leu Pro Ser Gln Asp Cys Lys Thr Val Ala Ile Lys 
                645                 650                 655     


Thr Leu Lys Asp Thr Ser Pro Gly Gly Gln Trp Trp Asn Phe Leu Arg 
            660                 665                 670         


Glu Ala Thr Ile Met Gly Gln Phe Ser His Pro His Ile Leu His Leu 
        675                 680                 685             


Glu Gly Val Val Thr Lys Arg Lys Pro Ile Met Ile Ile Thr Glu Phe 
    690                 695                 700                 


Met Glu Asn Gly Ala Leu Asp Ala Phe Leu Arg Glu Arg Glu Asp Gln 
705                 710                 715                 720 


Leu Val Pro Gly Gln Leu Val Ala Met Leu Gln Gly Ile Ala Ser Gly 
                725                 730                 735     


Met Asn Tyr Leu Ser Asn His Asn Tyr Val His Arg Asp Leu Ala Ala 
            740                 745                 750         


Arg Asn Ile Leu Val Asn Gln Asn Leu Cys Cys Lys Val Ser Asp Phe 
        755                 760                 765             


Gly Leu Thr Arg Leu Leu Asp Asp Phe Asp Gly Thr Tyr Glu Thr Gln 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala His 
785                 790                 795                 800 


Arg Ile Phe Thr Thr Ala Ser Asp Val Trp Ser Phe Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Leu Ser Phe Gly Asp Lys Pro Tyr Gly Glu Met Ser Asn 
            820                 825                 830         


Gln Glu Val Met Lys Ser Ile Glu Asp Gly Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Val Asp Cys Pro Ala Pro Leu Tyr Glu Leu Met Lys Asn Cys Trp Ala 
    850                 855                 860                 


Tyr Asp Arg Ala Arg Arg Pro His Phe Gln Lys Leu Gln Ala His Leu 
865                 870                 875                 880 


Glu Gln Leu Leu Ala Asn Pro His Ser Leu Arg Thr Ile Ala Asn Phe 
                885                 890                 895     


Asp Pro Arg Met Thr Leu Arg Leu Pro Ser Leu Ser Gly Ser Asp Gly 
            900                 905                 910         


Ile Pro Tyr Arg Thr Val Ser Glu Trp Leu Glu Ser Ile Arg Met Lys 
        915                 920                 925             


Arg Tyr Ile Leu His Phe His Ser Ala Gly Leu Asp Thr Met Glu Cys 
    930                 935                 940                 


Val Leu Glu Leu Thr Ala Glu Asp Leu Thr Gln Met Gly Ile Thr Leu 
945                 950                 955                 960 


Pro Gly His Gln Lys Arg Ile Leu Cys Ser Ile Gln Gly Phe Lys Asp 
                965                 970                 975     


<210>  419
<211>  983
<212>  PRT
<213>  Homo sapiens

<400>  419

Met Asp Cys Gln Leu Ser Ile Leu Leu Leu Leu Ser Cys Ser Val Leu 
1               5                   10                  15      


Asp Ser Phe Gly Glu Leu Ile Pro Gln Pro Ser Asn Glu Val Asn Leu 
            20                  25                  30          


Leu Asp Ser Lys Thr Ile Gln Gly Glu Leu Gly Trp Ile Ser Tyr Pro 
        35                  40                  45              


Ser His Gly Trp Glu Glu Ile Ser Gly Val Asp Glu His Tyr Thr Pro 
    50                  55                  60                  


Ile Arg Thr Tyr Gln Val Cys Asn Val Met Asp His Ser Gln Asn Asn 
65                  70                  75                  80  


Trp Leu Arg Thr Asn Trp Val Pro Arg Asn Ser Ala Gln Lys Ile Tyr 
                85                  90                  95      


Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Ile Pro Leu Val 
            100                 105                 110         


Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Met Glu Ser Asp 
        115                 120                 125             


Asp Asp His Gly Val Lys Phe Arg Glu His Gln Phe Thr Lys Ile Asp 
    130                 135                 140                 


Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Met Asp Leu Gly Asp Arg 
145                 150                 155                 160 


Ile Leu Lys Leu Asn Thr Glu Ile Arg Glu Val Gly Pro Val Asn Lys 
                165                 170                 175     


Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Val Ala Leu 
            180                 185                 190         


Val Ser Val Arg Val Tyr Phe Lys Lys Cys Pro Phe Thr Val Lys Asn 
        195                 200                 205             


Leu Ala Met Phe Pro Asp Thr Val Pro Met Asp Ser Gln Ser Leu Val 
    210                 215                 220                 


Glu Val Arg Gly Ser Cys Val Asn Asn Ser Lys Glu Glu Asp Pro Pro 
225                 230                 235                 240 


Arg Met Tyr Cys Ser Thr Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
                245                 250                 255     


Cys Ser Cys Asn Ala Gly Tyr Glu Glu Arg Gly Phe Met Cys Gln Ala 
            260                 265                 270         


Cys Arg Pro Gly Phe Tyr Lys Ala Leu Asp Gly Asn Met Lys Cys Ala 
        275                 280                 285             


Lys Cys Pro Pro His Ser Ser Thr Gln Glu Asp Gly Ser Met Asn Cys 
    290                 295                 300                 


Arg Cys Glu Asn Asn Tyr Phe Arg Ala Asp Lys Asp Pro Pro Ser Met 
305                 310                 315                 320 


Ala Cys Thr Arg Pro Pro Ser Ser Pro Arg Asn Val Ile Ser Asn Ile 
                325                 330                 335     


Asn Glu Thr Ser Val Ile Leu Asp Trp Ser Trp Pro Leu Asp Thr Gly 
            340                 345                 350         


Gly Arg Lys Asp Val Thr Phe Asn Ile Ile Cys Lys Lys Cys Gly Trp 
        355                 360                 365             


Asn Ile Lys Gln Cys Glu Pro Cys Ser Pro Asn Val Arg Phe Leu Pro 
    370                 375                 380                 


Arg Gln Phe Gly Leu Thr Asn Thr Thr Val Thr Val Thr Asp Leu Leu 
385                 390                 395                 400 


Ala His Thr Asn Tyr Thr Phe Glu Ile Asp Ala Val Asn Gly Val Ser 
                405                 410                 415     


Glu Leu Ser Ser Pro Pro Arg Gln Phe Ala Ala Val Ser Ile Thr Thr 
            420                 425                 430         


Asn Gln Ala Ala Pro Ser Pro Val Leu Thr Ile Lys Lys Asp Arg Thr 
        435                 440                 445             


Ser Arg Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Glu His Pro Asn 
    450                 455                 460                 


Gly Ile Ile Leu Asp Tyr Glu Val Lys Tyr Tyr Glu Lys Gln Glu Gln 
465                 470                 475                 480 


Glu Thr Ser Tyr Thr Ile Leu Arg Ala Arg Gly Thr Asn Val Thr Ile 
                485                 490                 495     


Ser Ser Leu Lys Pro Asp Thr Ile Tyr Val Phe Gln Ile Arg Ala Arg 
            500                 505                 510         


Thr Ala Ala Gly Tyr Gly Thr Asn Ser Arg Lys Phe Glu Phe Glu Thr 
        515                 520                 525             


Ser Pro Asp Ser Phe Ser Ile Ser Gly Glu Ser Ser Gln Val Val Met 
    530                 535                 540                 


Ile Ala Ile Ser Ala Ala Val Ala Ile Ile Leu Leu Thr Val Val Ile 
545                 550                 555                 560 


Tyr Val Leu Ile Gly Arg Phe Cys Gly Tyr Lys Ser Lys His Gly Ala 
                565                 570                 575     


Asp Glu Lys Arg Leu His Phe Gly Asn Gly His Leu Lys Leu Pro Gly 
            580                 585                 590         


Leu Arg Thr Tyr Val Asp Pro His Thr Tyr Glu Asp Pro Thr Gln Ala 
        595                 600                 605             


Val His Glu Phe Ala Lys Glu Leu Asp Ala Thr Asn Ile Ser Ile Asp 
    610                 615                 620                 


Lys Val Val Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Leu Pro Ser Lys Lys Glu Ile Ser Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Gly Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Lys Pro Val Met Ile Val Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Ala Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Ile Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ser Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Leu Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Glu Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Val Asp Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Asn Arg Pro Lys Phe Glu Gln Ile Val Ser Ile Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Gly Ser Leu Lys Ile Ile Thr Ser Ala Ala Ala 
                885                 890                 895     


Arg Pro Ser Asn Leu Leu Leu Asp Gln Ser Asn Val Asp Ile Thr Thr 
            900                 905                 910         


Phe Arg Thr Thr Gly Asp Trp Leu Asn Gly Val Trp Thr Ala His Cys 
        915                 920                 925             


Lys Glu Ile Phe Thr Gly Val Glu Tyr Ser Ser Cys Asp Thr Ile Ala 
    930                 935                 940                 


Lys Ile Ser Thr Asp Asp Met Lys Lys Val Gly Val Thr Val Val Gly 
945                 950                 955                 960 


Pro Gln Lys Lys Ile Ile Ser Ser Ile Lys Ala Leu Glu Thr Gln Ser 
                965                 970                 975     


Lys Asn Gly Pro Val Pro Val 
            980             


<210>  420
<211>  986
<212>  PRT
<213>  Homo sapiens

<400>  420

Met Ala Gly Ile Phe Tyr Phe Ala Leu Phe Ser Cys Leu Phe Gly Ile 
1               5                   10                  15      


Cys Asp Ala Val Thr Gly Ser Arg Val Tyr Pro Ala Asn Glu Val Thr 
            20                  25                  30          


Leu Leu Asp Ser Arg Ser Val Gln Gly Glu Leu Gly Trp Ile Ala Ser 
        35                  40                  45              


Pro Leu Glu Gly Gly Trp Glu Glu Val Ser Ile Met Asp Glu Lys Asn 
    50                  55                  60                  


Thr Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Met Glu Pro Ser Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Asp Trp Ile Thr Arg Glu Gly Ala Gln Arg 
                85                  90                  95      


Val Tyr Ile Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro 
            100                 105                 110         


Gly Val Met Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr Glu 
        115                 120                 125             


Ser Asp Asn Asp Lys Glu Arg Phe Ile Arg Glu Asn Gln Phe Val Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Val Asp Ile Gly 
145                 150                 155                 160 


Asp Arg Ile Met Lys Leu Asn Thr Glu Ile Arg Asp Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile 
            180                 185                 190         


Ala Leu Val Ser Val Arg Val Phe Tyr Lys Lys Cys Pro Leu Thr Val 
        195                 200                 205             


Arg Asn Leu Ala Gln Phe Pro Asp Thr Ile Thr Gly Ala Asp Thr Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Ser Cys Val Asn Asn Ser Glu Glu Lys 
225                 230                 235                 240 


Asp Val Pro Lys Met Tyr Cys Gly Ala Asp Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Asn Cys Leu Cys Asn Ala Gly His Glu Glu Arg Ser Gly Glu 
            260                 265                 270         


Cys Gln Ala Cys Lys Ile Gly Tyr Tyr Lys Ala Leu Ser Thr Asp Ala 
        275                 280                 285             


Thr Cys Ala Lys Cys Pro Pro His Ser Tyr Ser Val Trp Glu Gly Ala 
    290                 295                 300                 


Thr Ser Cys Thr Cys Asp Arg Gly Phe Phe Arg Ala Asp Asn Asp Ala 
305                 310                 315                 320 


Ala Ser Met Pro Cys Thr Arg Pro Pro Ser Ala Pro Leu Asn Leu Ile 
                325                 330                 335     


Ser Asn Val Asn Glu Thr Ser Val Asn Leu Glu Trp Ser Ser Pro Gln 
            340                 345                 350         


Asn Thr Gly Gly Arg Gln Asp Ile Ser Tyr Asn Val Val Cys Lys Lys 
        355                 360                 365             


Cys Gly Ala Gly Asp Pro Ser Lys Cys Arg Pro Cys Gly Ser Gly Val 
    370                 375                 380                 


His Tyr Thr Pro Gln Gln Asn Gly Leu Lys Thr Thr Lys Val Ser Ile 
385                 390                 395                 400 


Thr Asp Leu Leu Ala His Thr Asn Tyr Thr Phe Glu Ile Trp Ala Val 
                405                 410                 415     


Asn Gly Val Ser Lys Tyr Asn Pro Asn Pro Asp Gln Ser Val Ser Val 
            420                 425                 430         


Thr Val Thr Thr Asn Gln Ala Ala Pro Ser Ser Ile Ala Leu Val Gln 
        435                 440                 445             


Ala Lys Glu Val Thr Arg Tyr Ser Val Ala Leu Ala Trp Leu Glu Pro 
    450                 455                 460                 


Asp Arg Pro Asn Gly Val Ile Leu Glu Tyr Glu Val Lys Tyr Tyr Glu 
465                 470                 475                 480 


Lys Asp Gln Asn Glu Arg Ser Tyr Arg Ile Val Arg Thr Ala Ala Arg 
                485                 490                 495     


Asn Thr Asp Ile Lys Gly Leu Asn Pro Leu Thr Ser Tyr Val Phe His 
            500                 505                 510         


Val Arg Ala Arg Thr Ala Ala Gly Tyr Gly Asp Phe Ser Glu Pro Leu 
        515                 520                 525             


Glu Val Thr Thr Asn Thr Val Pro Ser Arg Ile Ile Gly Asp Gly Ala 
    530                 535                 540                 


Asn Ser Thr Val Leu Leu Val Ser Val Ser Gly Ser Val Val Leu Val 
545                 550                 555                 560 


Val Ile Leu Ile Ala Ala Phe Val Ile Ser Arg Arg Arg Ser Lys Tyr 
                565                 570                 575     


Ser Lys Ala Lys Gln Glu Ala Asp Glu Glu Lys His Leu Asn Gln Gly 
            580                 585                 590         


Val Arg Thr Tyr Val Asp Pro Phe Thr Tyr Glu Asp Pro Asn Gln Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ala Ser Cys Ile Lys Ile Glu 
    610                 615                 620                 


Lys Val Ile Gly Val Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu 
625                 630                 635                 640 


Lys Val Pro Gly Lys Arg Glu Ile Cys Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ala Gly Tyr Thr Asp Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Ile Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Cys Lys Pro Val Met Ile Ile Thr Glu Tyr Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ala Phe Leu Arg Lys Asn Asp Gly Arg Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Gly Ser Gly Met Lys Tyr 
                725                 730                 735     


Leu Ser Asp Met Ser Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Met Ser 
        755                 760                 765             


Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Arg Gly Gly 
    770                 775                 780                 


Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Lys Ala Ile Glu Glu Gly Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ile Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu 
    850                 855                 860                 


Arg Ser Asp Arg Pro Lys Phe Gly Gln Ile Val Asn Met Leu Asp Lys 
865                 870                 875                 880 


Leu Ile Arg Asn Pro Asn Ser Leu Lys Arg Thr Gly Thr Glu Ser Ser 
                885                 890                 895     


Arg Pro Asn Thr Ala Leu Leu Asp Pro Ser Ser Pro Glu Phe Ser Ala 
            900                 905                 910         


Val Val Ser Val Gly Asp Trp Leu Gln Ala Ile Lys Met Asp Arg Tyr 
        915                 920                 925             


Lys Asp Asn Phe Thr Ala Ala Gly Tyr Thr Thr Leu Glu Ala Val Val 
    930                 935                 940                 


His Val Asn Gln Glu Asp Leu Ala Arg Ile Gly Ile Thr Ala Ile Thr 
945                 950                 955                 960 


His Gln Asn Lys Ile Leu Ser Ser Val Gln Ala Met Arg Thr Gln Met 
                965                 970                 975     


Gln Gln Met His Gly Arg Met Val Pro Val 
            980                 985     


<210>  421
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  421

Met Arg Gly Ser Gly Pro Arg Gly Ala Gly Arg Arg Arg Pro Pro Ser 
1               5                   10                  15      


Gly Gly Gly Asp Thr Pro Ile Thr Pro Ala Ser Leu Ala Gly Cys Tyr 
            20                  25                  30          


Ser Ala Pro Arg Arg Ala Pro Leu Trp Thr Cys Leu Leu Leu Cys Ala 
        35                  40                  45              


Ala Leu Arg Thr Leu Leu Ala Ser Pro Ser Asn Glu Val Asn Leu Leu 
    50                  55                  60                  


Asp Ser Arg Thr Val Met Gly Asp Leu Gly Trp Ile Ala Phe Pro Lys 
65                  70                  75                  80  


Asn Gly Trp Glu Glu Ile Gly Glu Val Asp Glu Asn Tyr Ala Pro Ile 
                85                  90                  95      


His Thr Tyr Gln Val Cys Lys Val Met Glu Gln Asn Gln Asn Asn Trp 
            100                 105                 110         


Leu Leu Thr Ser Trp Ile Ser Asn Glu Gly Ala Ser Arg Ile Phe Ile 
        115                 120                 125             


Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu Pro Gly Gly Leu 
    130                 135                 140                 


Gly Thr Cys Lys Glu Thr Phe Asn Met Tyr Tyr Phe Glu Ser Asp Asp 
145                 150                 155                 160 


Gln Asn Gly Arg Asn Ile Lys Glu Asn Gln Tyr Ile Lys Ile Asp Thr 
                165                 170                 175     


Ile Ala Ala Asp Glu Ser Phe Thr Glu Leu Asp Leu Gly Asp Arg Val 
            180                 185                 190         


Met Lys Leu Asn Thr Glu Val Arg Asp Val Gly Pro Leu Ser Lys Lys 
        195                 200                 205             


Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys Ile Ala Leu Val 
    210                 215                 220                 


Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro Ser Val Val Arg His Leu 
225                 230                 235                 240 


Ala Val Phe Pro Asp Thr Ile Thr Gly Ala Asp Ser Ser Gln Leu Leu 
                245                 250                 255     


Glu Val Ser Gly Ser Cys Val Asn His Ser Val Thr Asp Glu Pro Pro 
            260                 265                 270         


Lys Met His Cys Ser Ala Glu Gly Glu Trp Leu Val Pro Ile Gly Lys 
        275                 280                 285             


Cys Met Cys Lys Ala Gly Tyr Glu Glu Lys Asn Gly Thr Cys Gln Val 
    290                 295                 300                 


Cys Arg Pro Gly Phe Phe Lys Ala Ser Pro His Ile Gln Ser Cys Gly 
305                 310                 315                 320 


Lys Cys Pro Pro His Ser Tyr Thr His Glu Glu Ala Ser Thr Ser Cys 
                325                 330                 335     


Val Cys Glu Lys Asp Tyr Phe Arg Arg Glu Ser Asp Pro Pro Thr Met 
            340                 345                 350         


Ala Cys Thr Arg Pro Pro Ser Ala Pro Arg Asn Ala Ile Ser Asn Val 
        355                 360                 365             


Asn Glu Thr Ser Val Phe Leu Glu Trp Ile Pro Pro Ala Asp Thr Gly 
    370                 375                 380                 


Gly Arg Lys Asp Val Ser Tyr Tyr Ile Ala Cys Lys Lys Cys Asn Ser 
385                 390                 395                 400 


His Ala Gly Val Cys Glu Glu Cys Gly Gly His Val Arg Tyr Leu Pro 
                405                 410                 415     


Arg Gln Ser Gly Leu Lys Asn Thr Ser Val Met Met Val Asp Leu Leu 
            420                 425                 430         


Ala His Thr Asn Tyr Thr Phe Glu Ile Glu Ala Val Asn Gly Val Ser 
        435                 440                 445             


Asp Leu Ser Pro Gly Ala Arg Gln Tyr Val Ser Val Asn Val Thr Thr 
    450                 455                 460                 


Asn Gln Ala Ala Pro Ser Pro Val Thr Asn Val Lys Lys Gly Lys Ile 
465                 470                 475                 480 


Ala Lys Asn Ser Ile Ser Leu Ser Trp Gln Glu Pro Asp Arg Pro Asn 
                485                 490                 495     


Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Phe Glu Lys Asp Gln Glu 
            500                 505                 510         


Thr Ser Tyr Thr Ile Ile Lys Ser Lys Glu Thr Thr Ile Thr Ala Glu 
        515                 520                 525             


Gly Leu Lys Pro Ala Ser Val Tyr Val Phe Gln Ile Arg Ala Arg Thr 
    530                 535                 540                 


Ala Ala Gly Tyr Gly Val Phe Ser Arg Arg Phe Glu Phe Glu Thr Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ala Ser Ser Asp Gln Ser Gln Ile Pro Val Ile Ala 
                565                 570                 575     


Val Ser Val Thr Val Gly Val Ile Leu Leu Ala Val Val Ile Gly Val 
            580                 585                 590         


Leu Leu Ser Gly Ser Cys Cys Glu Cys Gly Cys Gly Arg Ala Ser Ser 
        595                 600                 605             


Leu Cys Ala Val Ala His Pro Ser Leu Ile Trp Arg Cys Gly Tyr Ser 
    610                 615                 620                 


Lys Ala Lys Gln Asp Pro Glu Glu Glu Lys Met His Phe His Asn Gly 
625                 630                 635                 640 


His Ile Lys Leu Pro Gly Val Arg Thr Tyr Ile Asp Pro His Thr Tyr 
                645                 650                 655     


Glu Asp Pro Asn Gln Ala Val His Glu Phe Ala Lys Glu Ile Glu Ala 
            660                 665                 670         


Ser Cys Ile Thr Ile Glu Arg Val Ile Gly Ala Gly Glu Phe Gly Glu 
        675                 680                 685             


Val Cys Ser Gly Arg Leu Lys Leu Pro Gly Lys Arg Glu Leu Pro Val 
    690                 695                 700                 


Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr Glu Lys Gln Arg Arg Asp 
705                 710                 715                 720 


Phe Leu Gly Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro Asn Ile 
                725                 730                 735     


Ile His Leu Glu Gly Val Val Thr Lys Ser Lys Pro Val Met Ile Val 
            740                 745                 750         


Thr Glu Tyr Met Glu Asn Gly Ser Leu Asp Thr Phe Leu Lys Lys Asn 
        755                 760                 765             


Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile 
    770                 775                 780                 


Ser Ala Gly Met Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp 
785                 790                 795                 800 


Leu Ala Ala Arg Asn Ile Leu Ile Asn Ser Asn Leu Val Cys Lys Val 
                805                 810                 815     


Ser Asp Phe Gly Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala 
            820                 825                 830         


Tyr Thr Thr Arg Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu 
        835                 840                 845             


Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr 
    850                 855                 860                 


Gly Ile Val Met Trp Glu Val Val Ser Tyr Gly Glu Arg Pro Tyr Trp 
865                 870                 875                 880 


Glu Met Thr Asn Gln Asp Val Ile Lys Ala Val Glu Glu Gly Tyr Arg 
                885                 890                 895     


Leu Pro Ser Pro Met Asp Cys Pro Ala Ala Leu Tyr Gln Leu Met Leu 
            900                 905                 910         


Asp Cys Trp Gln Lys Glu Arg Asn Ser Arg Pro Lys Phe Asp Glu Ile 
        915                 920                 925             


Val Asn Met Leu Asp Lys Leu Ile Arg Asn Pro Ser Ser Leu Lys Thr 
    930                 935                 940                 


Leu Val Asn Ala Ser Cys Arg Val Ser Asn Leu Leu Ala Glu His Ser 
945                 950                 955                 960 


Pro Leu Gly Ser Gly Ala Tyr Arg Ser Val Gly Glu Trp Leu Glu Ala 
                965                 970                 975     


Ile Lys Met Gly Arg Tyr Thr Glu Ile Phe Met Glu Asn Gly Tyr Ser 
            980                 985                 990         


Ser Met Asp Ala Val Ala Gln Val  Thr Leu Glu Asp Leu  Arg Arg Leu 
        995                 1000                 1005             


Gly Val  Thr Leu Val Gly His  Gln Lys Lys Ile Met  Asn Ser Leu 
    1010                 1015                 1020             


Gln Glu  Met Lys Val Gln Leu  Val Asn Gly Met Val  Pro Leu 
    1025                 1030                 1035         


<210>  422
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  422

Met Val Phe Gln Thr Arg Tyr Pro Ser Trp Ile Ile Leu Cys Tyr Ile 
1               5                   10                  15      


Trp Leu Leu Arg Phe Ala His Thr Gly Glu Ala Gln Ala Ala Lys Glu 
            20                  25                  30          


Val Leu Leu Leu Asp Ser Lys Ala Gln Gln Thr Glu Leu Glu Trp Ile 
        35                  40                  45              


Ser Ser Pro Pro Asn Gly Trp Glu Glu Ile Ser Gly Leu Asp Glu Asn 
    50                  55                  60                  


Tyr Thr Pro Ile Arg Thr Tyr Gln Val Cys Gln Val Met Glu Pro Asn 
65                  70                  75                  80  


Gln Asn Asn Trp Leu Arg Thr Asn Trp Ile Ser Lys Gly Asn Ala Gln 
                85                  90                  95      


Arg Ile Phe Val Glu Leu Lys Phe Thr Leu Arg Asp Cys Asn Ser Leu 
            100                 105                 110         


Pro Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Tyr 
        115                 120                 125             


Glu Thr Asp Tyr Asp Thr Gly Arg Asn Ile Arg Glu Asn Leu Tyr Val 
    130                 135                 140                 


Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gln Gly Asp Leu 
145                 150                 155                 160 


Gly Glu Arg Lys Met Lys Leu Asn Thr Glu Val Arg Glu Ile Gly Pro 
                165                 170                 175     


Leu Ser Lys Lys Gly Phe Tyr Leu Ala Phe Gln Asp Val Gly Ala Cys 
            180                 185                 190         


Ile Ala Leu Val Ser Val Lys Val Tyr Tyr Lys Lys Cys Trp Ser Ile 
        195                 200                 205             


Ile Glu Asn Leu Ala Ile Phe Pro Asp Thr Val Thr Gly Ser Glu Phe 
    210                 215                 220                 


Ser Ser Leu Val Glu Val Arg Gly Thr Cys Val Ser Ser Ala Glu Glu 
225                 230                 235                 240 


Glu Ala Glu Asn Ala Pro Arg Met His Cys Ser Ala Glu Gly Glu Trp 
                245                 250                 255     


Leu Val Pro Ile Gly Lys Cys Ile Cys Lys Ala Gly Tyr Gln Gln Lys 
            260                 265                 270         


Gly Asp Thr Cys Glu Pro Cys Gly Arg Gly Phe Tyr Lys Ser Ser Ser 
        275                 280                 285             


Gln Asp Leu Gln Cys Ser Arg Cys Pro Thr His Ser Phe Ser Asp Lys 
    290                 295                 300                 


Glu Gly Ser Ser Arg Cys Glu Cys Glu Asp Gly Tyr Tyr Arg Ala Pro 
305                 310                 315                 320 


Ser Asp Pro Pro Tyr Val Ala Cys Thr Arg Pro Pro Ser Ala Pro Gln 
                325                 330                 335     


Asn Leu Ile Phe Asn Ile Asn Gln Thr Thr Val Ser Leu Glu Trp Ser 
            340                 345                 350         


Pro Pro Ala Asp Asn Gly Gly Arg Asn Asp Val Thr Tyr Arg Ile Leu 
        355                 360                 365             


Cys Lys Arg Cys Ser Trp Glu Gln Gly Glu Cys Val Pro Cys Gly Ser 
    370                 375                 380                 


Asn Ile Gly Tyr Met Pro Gln Gln Thr Gly Leu Glu Asp Asn Tyr Val 
385                 390                 395                 400 


Thr Val Met Asp Leu Leu Ala His Ala Asn Tyr Thr Phe Glu Val Glu 
                405                 410                 415     


Ala Val Asn Gly Val Ser Asp Leu Ser Arg Ser Gln Arg Leu Phe Ala 
            420                 425                 430         


Ala Val Ser Ile Thr Thr Gly Gln Ala Ala Pro Ser Gln Val Ser Gly 
        435                 440                 445             


Val Met Lys Glu Arg Val Leu Gln Arg Ser Val Glu Leu Ser Trp Gln 
    450                 455                 460                 


Glu Pro Glu His Pro Asn Gly Val Ile Thr Glu Tyr Glu Ile Lys Tyr 
465                 470                 475                 480 


Tyr Glu Lys Asp Gln Arg Glu Arg Thr Tyr Ser Thr Val Lys Thr Lys 
                485                 490                 495     


Ser Thr Ser Ala Ser Ile Asn Asn Leu Lys Pro Gly Thr Val Tyr Val 
            500                 505                 510         


Phe Gln Ile Arg Ala Phe Thr Ala Ala Gly Tyr Gly Asn Tyr Ser Pro 
        515                 520                 525             


Arg Leu Asp Val Ala Thr Leu Glu Glu Ala Thr Gly Lys Met Phe Glu 
    530                 535                 540                 


Ala Thr Ala Val Ser Ser Glu Gln Asn Pro Val Ile Ile Ile Ala Val 
545                 550                 555                 560 


Val Ala Val Ala Gly Thr Ile Ile Leu Val Phe Met Val Phe Gly Phe 
                565                 570                 575     


Ile Ile Gly Arg Arg His Cys Gly Tyr Ser Lys Ala Asp Gln Glu Gly 
            580                 585                 590         


Asp Glu Glu Leu Tyr Phe His Phe Lys Phe Pro Gly Thr Lys Thr Tyr 
        595                 600                 605             


Ile Asp Pro Glu Thr Tyr Glu Asp Pro Asn Arg Ala Val His Gln Phe 
    610                 615                 620                 


Ala Lys Glu Leu Asp Ala Ser Cys Ile Lys Ile Glu Arg Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Ser Gly Arg Leu Lys Leu Pro Gly 
                645                 650                 655     


Lys Arg Asp Val Ala Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Lys Gln Arg Arg Asp Phe Leu Cys Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Val Val His Leu Glu Gly Val Val Thr Arg Gly 
    690                 695                 700                 


Lys Pro Val Met Ile Val Ile Glu Phe Met Glu Asn Gly Ala Leu Asp 
705                 710                 715                 720 


Ala Phe Leu Arg Lys His Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Arg Tyr Leu Ala Asp Met 
            740                 745                 750         


Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val Ile Glu 
    770                 775                 780                 


Asp Asp Pro Glu Ala Val Tyr Thr Thr Thr Gly Gly Lys Ile Pro Val 
785                 790                 795                 800 


Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr Arg Lys Phe Thr Ser Ala 
                805                 810                 815     


Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Tyr 
            820                 825                 830         


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Lys Ala 
        835                 840                 845             


Ile Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Asp Cys Pro Ala Gly 
    850                 855                 860                 


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Glu Arg Ala Glu Arg 
865                 870                 875                 880 


Pro Lys Phe Glu Gln Ile Val Gly Ile Leu Asp Lys Met Ile Arg Asn 
                885                 890                 895     


Pro Asn Ser Leu Lys Thr Pro Leu Gly Thr Cys Ser Arg Pro Ile Ser 
            900                 905                 910         


Pro Leu Leu Asp Gln Asn Thr Pro Asp Phe Thr Thr Phe Cys Ser Val 
        915                 920                 925             


Gly Glu Trp Leu Gln Ala Ile Lys Met Glu Arg Tyr Lys Asp Asn Phe 
    930                 935                 940                 


Thr Ala Ala Gly Tyr Asn Ser Leu Glu Ser Val Ala Arg Met Thr Ile 
945                 950                 955                 960 


Glu Asp Val Met Ser Leu Gly Ile Thr Leu Val Gly His Gln Lys Lys 
                965                 970                 975     


Ile Met Ser Ser Ile Gln Thr Met Arg Ala Gln Met Leu His Leu His 
            980                 985                 990         


Gly Thr Gly Ile Gln Val 
        995             


<210>  423
<211>  1005
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Ala Pro Ala Arg Gly Arg Leu Pro Pro Ala Leu Trp Val Val Thr 
1               5                   10                  15      


Ala Ala Ala Ala Ala Ala Thr Cys Val Ser Ala Ala Arg Gly Glu Val 
            20                  25                  30          


Asn Leu Leu Asp Thr Ser Thr Ile His Gly Asp Trp Gly Trp Leu Thr 
        35                  40                  45              


Tyr Pro Ala His Gly Trp Asp Ser Ile Asn Glu Val Asp Glu Ser Phe 
    50                  55                  60                  


Gln Pro Ile His Thr Tyr Gln Val Cys Asn Val Met Ser Pro Asn Gln 
65                  70                  75                  80  


Asn Asn Trp Leu Arg Thr Ser Trp Val Pro Arg Asp Gly Ala Arg Arg 
                85                  90                  95      


Val Tyr Ala Glu Ile Lys Phe Thr Leu Arg Asp Cys Asn Ser Met Pro 
            100                 105                 110         


Gly Val Leu Gly Thr Cys Lys Glu Thr Phe Asn Leu Tyr Tyr Leu Glu 
        115                 120                 125             


Ser Asp Arg Asp Leu Gly Ala Ser Thr Gln Glu Ser Gln Phe Leu Lys 
    130                 135                 140                 


Ile Asp Thr Ile Ala Ala Asp Glu Ser Phe Thr Gly Ala Asp Leu Gly 
145                 150                 155                 160 


Val Arg Arg Leu Lys Leu Asn Thr Glu Val Arg Ser Val Gly Pro Leu 
                165                 170                 175     


Ser Lys Arg Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly Ala Cys Leu 
            180                 185                 190         


Ala Ile Leu Ser Leu Arg Ile Tyr Tyr Lys Lys Cys Pro Ala Met Val 
        195                 200                 205             


Arg Asn Leu Ala Ala Phe Ser Glu Ala Val Thr Gly Ala Asp Ser Ser 
    210                 215                 220                 


Ser Leu Val Glu Val Arg Gly Gln Cys Val Arg His Ser Glu Glu Arg 
225                 230                 235                 240 


Asp Thr Pro Lys Met Tyr Cys Ser Ala Glu Gly Glu Trp Leu Val Pro 
                245                 250                 255     


Ile Gly Lys Cys Val Cys Ser Ala Gly Tyr Glu Glu Arg Arg Asp Ala 
            260                 265                 270         


Cys Val Ala Cys Glu Leu Gly Phe Tyr Lys Ser Ala Pro Gly Asp Gln 
        275                 280                 285             


Leu Cys Ala Arg Cys Pro Pro His Ser His Ser Ala Ala Pro Ala Ala 
    290                 295                 300                 


Gln Ala Cys His Cys Asp Leu Ser Tyr Tyr Arg Ala Ala Leu Asp Pro 
305                 310                 315                 320 


Pro Ser Ser Ala Cys Thr Arg Pro Pro Ser Ala Pro Val Asn Leu Ile 
                325                 330                 335     


Ser Ser Val Asn Gly Thr Ser Val Thr Leu Glu Trp Ala Pro Pro Leu 
            340                 345                 350         


Asp Pro Gly Gly Arg Ser Asp Ile Thr Tyr Asn Ala Val Cys Arg Arg 
        355                 360                 365             


Cys Pro Trp Ala Leu Ser Arg Cys Glu Ala Cys Gly Ser Gly Thr Arg 
    370                 375                 380                 


Phe Val Pro Gln Gln Thr Ser Leu Val Gln Ala Ser Leu Leu Val Ala 
385                 390                 395                 400 


Asn Leu Leu Ala His Met Asn Tyr Ser Phe Trp Ile Glu Ala Val Asn 
                405                 410                 415     


Gly Val Ser Asp Leu Ser Pro Glu Pro Arg Arg Ala Ala Val Val Asn 
            420                 425                 430         


Ile Thr Thr Asn Gln Ala Ala Pro Ser Gln Val Val Val Ile Arg Gln 
        435                 440                 445             


Glu Arg Ala Gly Gln Thr Ser Val Ser Leu Leu Trp Gln Glu Pro Glu 
    450                 455                 460                 


Gln Pro Asn Gly Ile Ile Leu Glu Tyr Glu Ile Lys Tyr Tyr Glu Lys 
465                 470                 475                 480 


Asp Lys Glu Met Gln Ser Tyr Ser Thr Leu Lys Ala Val Thr Thr Arg 
                485                 490                 495     


Ala Thr Val Ser Gly Leu Lys Pro Gly Thr Arg Tyr Val Phe Gln Val 
            500                 505                 510         


Arg Ala Arg Thr Ser Ala Gly Cys Gly Arg Phe Ser Gln Ala Met Glu 
        515                 520                 525             


Val Glu Thr Gly Lys Pro Arg Pro Arg Tyr Asp Thr Arg Thr Ile Val 
    530                 535                 540                 


Trp Ile Cys Leu Thr Leu Ile Thr Gly Leu Val Val Leu Leu Leu Leu 
545                 550                 555                 560 


Leu Ile Cys Lys Lys Arg His Cys Gly Tyr Ser Lys Ala Phe Gln Asp 
                565                 570                 575     


Ser Asp Glu Glu Lys Met His Tyr Gln Asn Gly Gln Ala Pro Pro Pro 
            580                 585                 590         


Val Phe Leu Pro Leu His His Pro Pro Gly Lys Leu Pro Glu Pro Gln 
        595                 600                 605             


Phe Tyr Ala Glu Pro His Thr Tyr Glu Glu Pro Gly Arg Ala Gly Arg 
    610                 615                 620                 


Ser Phe Thr Arg Glu Ile Glu Ala Ser Arg Ile His Ile Glu Lys Ile 
625                 630                 635                 640 


Ile Gly Ser Gly Asp Ser Gly Glu Val Cys Tyr Gly Arg Leu Arg Val 
                645                 650                 655     


Pro Gly Gln Arg Asp Val Pro Val Ala Ile Lys Ala Leu Lys Ala Gly 
            660                 665                 670         


Tyr Thr Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
        675                 680                 685             


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
    690                 695                 700                 


Arg Gly Arg Leu Ala Met Ile Val Thr Glu Tyr Met Glu Asn Gly Ser 
705                 710                 715                 720 


Leu Asp Thr Phe Leu Arg Thr His Asp Gly Gln Phe Thr Ile Met Gln 
                725                 730                 735     


Leu Val Gly Met Leu Arg Gly Val Gly Ala Gly Met Arg Tyr Leu Ser 
            740                 745                 750         


Asp Leu Gly Tyr Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
        755                 760                 765             


Asp Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Val 
    770                 775                 780                 


Leu Glu Asp Asp Pro Asp Ala Ala Tyr Thr Thr Thr Gly Gly Lys Ile 
785                 790                 795                 800 


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Thr Phe Ser 
                805                 810                 815     


Ser Ala Ser Asp Val Trp Ser Phe Gly Val Val Met Trp Glu Val Leu 
            820                 825                 830         


Ala Tyr Gly Glu Arg Pro Tyr Trp Asn Met Thr Asn Arg Asp Val Ile 
        835                 840                 845             


Ser Ser Val Glu Glu Gly Tyr Arg Leu Pro Ala Pro Met Gly Cys Pro 
    850                 855                 860                 


His Ala Leu His Gln Leu Met Leu Asp Cys Trp His Lys Asp Arg Ala 
865                 870                 875                 880 


Gln Arg Pro Arg Phe Ser Gln Ile Val Ser Val Leu Asp Ala Leu Ile 
                885                 890                 895     


Arg Ser Pro Glu Ser Leu Arg Ala Thr Ala Thr Val Ser Arg Cys Pro 
            900                 905                 910         


Pro Pro Ala Phe Val Arg Ser Cys Phe Asp Leu Arg Gly Gly Ser Gly 
        915                 920                 925             


Gly Gly Gly Gly Leu Thr Val Gly Asp Trp Leu Asp Ser Ile Arg Met 
    930                 935                 940                 


Gly Arg Tyr Arg Asp His Phe Ala Ala Gly Gly Tyr Ser Ser Leu Gly 
945                 950                 955                 960 


Met Val Leu Arg Met Asn Ala Gln Asp Val Arg Ala Leu Gly Ile Thr 
                965                 970                 975     


Leu Met Gly His Gln Lys Lys Ile Leu Gly Ser Ile Gln Thr Met Arg 
            980                 985                 990         


Ala Gln Leu Thr Ser Thr Gln Gly  Pro Arg Arg His Leu  
        995                 1000                 1005 


<210>  424
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  424

Met Ala Leu Asp Tyr Leu Leu Leu Leu Leu Leu Ala Ser Ala Val Ala 
1               5                   10                  15      


Ala Met Glu Glu Thr Leu Met Asp Thr Arg Thr Ala Thr Ala Glu Leu 
            20                  25                  30          


Gly Trp Thr Ala Asn Pro Ala Ser Gly Trp Glu Glu Val Ser Gly Tyr 
        35                  40                  45              


Asp Glu Asn Leu Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val Phe 
    50                  55                  60                  


Glu Pro Asn Gln Asn Asn Trp Leu Leu Thr Thr Phe Ile Asn Arg Arg 
65                  70                  75                  80  


Gly Ala His Arg Ile Tyr Thr Glu Met Arg Phe Thr Val Arg Asp Cys 
                85                  90                  95      


Ser Ser Leu Pro Asn Val Pro Gly Ser Cys Lys Glu Thr Phe Asn Leu 
            100                 105                 110         


Tyr Tyr Tyr Glu Thr Asp Ser Val Ile Ala Thr Lys Lys Ser Ala Phe 
        115                 120                 125             


Trp Ser Glu Ala Pro Tyr Leu Lys Val Asp Thr Ile Ala Ala Asp Glu 
    130                 135                 140                 


Ser Phe Ser Gln Val Asp Phe Gly Gly Arg Leu Met Lys Val Asn Thr 
145                 150                 155                 160 


Glu Val Arg Ser Phe Gly Pro Leu Thr Arg Asn Gly Phe Tyr Leu Ala 
                165                 170                 175     


Phe Gln Asp Tyr Gly Ala Cys Met Ser Leu Leu Ser Val Arg Val Phe 
            180                 185                 190         


Phe Lys Lys Cys Pro Ser Ile Val Gln Asn Phe Ala Val Phe Pro Glu 
        195                 200                 205             


Thr Met Thr Gly Ala Glu Ser Thr Ser Leu Val Ile Ala Arg Gly Thr 
    210                 215                 220                 


Cys Ile Pro Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr Cys 
225                 230                 235                 240 


Asn Gly Asp Gly Glu Trp Met Val Pro Ile Gly Arg Cys Thr Cys Lys 
                245                 250                 255     


Pro Gly Tyr Glu Pro Glu Asn Ser Val Ala Cys Lys Ala Cys Pro Ala 
            260                 265                 270         


Gly Thr Phe Lys Ala Ser Gln Glu Ala Glu Gly Cys Ser His Cys Pro 
        275                 280                 285             


Ser Asn Ser Arg Ser Pro Ala Glu Ala Ser Pro Ile Cys Thr Cys Arg 
    290                 295                 300                 


Thr Gly Tyr Tyr Arg Ala Asp Phe Asp Pro Pro Glu Val Ala Cys Thr 
305                 310                 315                 320 


Ser Val Pro Ser Gly Pro Arg Asn Val Ile Ser Ile Val Asn Glu Thr 
                325                 330                 335     


Ser Ile Ile Leu Glu Trp His Pro Pro Arg Glu Thr Gly Gly Arg Asp 
            340                 345                 350         


Asp Val Thr Tyr Asn Ile Ile Cys Lys Lys Cys Arg Ala Asp Arg Arg 
        355                 360                 365             


Ser Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro Arg Gln Leu 
    370                 375                 380                 


Gly Leu Thr Glu Cys Arg Val Ser Ile Ser Ser Leu Trp Ala His Thr 
385                 390                 395                 400 


Pro Tyr Thr Phe Asp Ile Gln Ala Ile Asn Gly Val Ser Ser Lys Ser 
                405                 410                 415     


Pro Phe Pro Pro Gln His Val Ser Val Asn Ile Thr Thr Asn Gln Ala 
            420                 425                 430         


Ala Pro Ser Thr Val Pro Ile Met His Gln Val Ser Ala Thr Met Arg 
        435                 440                 445             


Ser Ile Thr Leu Ser Trp Pro Gln Pro Glu Gln Pro Asn Gly Ile Ile 
    450                 455                 460                 


Leu Asp Tyr Glu Ile Arg Tyr Tyr Glu Lys Glu His Asn Glu Phe Asn 
465                 470                 475                 480 


Ser Ser Met Ala Arg Ser Gln Thr Asn Thr Ala Arg Ile Asp Gly Leu 
                485                 490                 495     


Arg Pro Gly Met Val Tyr Val Val Gln Val Arg Ala Arg Thr Val Ala 
            500                 505                 510         


Gly Tyr Gly Lys Phe Ser Gly Lys Met Cys Phe Gln Thr Leu Thr Asp 
        515                 520                 525             


Asp Asp Tyr Lys Ser Glu Leu Arg Glu Gln Leu Pro Leu Ile Ala Gly 
    530                 535                 540                 


Ser Ala Ala Ala Gly Val Val Phe Val Val Ser Leu Val Ala Ile Ser 
545                 550                 555                 560 


Ile Val Cys Ser Arg Lys Arg Ala Tyr Ser Lys Glu Ala Val Tyr Ser 
                565                 570                 575     


Asp Lys Leu Gln His Tyr Ser Thr Gly Arg Gly Ser Pro Gly Met Lys 
            580                 585                 590         


Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg 
        595                 600                 605             


Glu Phe Ala Lys Glu Ile Asp Val Ser Phe Val Lys Ile Glu Glu Val 
    610                 615                 620                 


Ile Gly Ala Gly Glu Phe Gly Glu Val Tyr Lys Gly Arg Leu Lys Leu 
625                 630                 635                 640 


Pro Gly Lys Arg Glu Ile Tyr Val Ala Ile Lys Thr Leu Lys Ala Gly 
                645                 650                 655     


Tyr Ser Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met 
            660                 665                 670         


Gly Gln Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr 
        675                 680                 685             


Lys Ser Arg Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn Gly Ala 
    690                 695                 700                 


Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val Ile Gln 
705                 710                 715                 720 


Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ala 
                725                 730                 735     


Glu Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val 
            740                 745                 750         


Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Tyr 
        755                 760                 765             


Leu Gln Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly 
    770                 775                 780                 


Lys Ile Pro Val Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys 
785                 790                 795                 800 


Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu 
                805                 810                 815     


Val Met Ser Phe Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp 
            820                 825                 830         


Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp 
        835                 840                 845             


Cys Pro Ala Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp 
    850                 855                 860                 


Arg Asn Ser Arg Pro Arg Phe Ala Glu Ile Val Asn Thr Leu Asp Lys 
865                 870                 875                 880 


Met Ile Arg Asn Pro Ala Ser Leu Lys Thr Val Ala Thr Ile Thr Ala 
                885                 890                 895     


Val Pro Ser Gln Pro Leu Leu Asp Arg Ser Ile Pro Asp Phe Thr Ala 
            900                 905                 910         


Phe Thr Thr Val Asp Asp Trp Leu Ser Ala Ile Lys Met Val Gln Tyr 
        915                 920                 925             


Arg Asp Ser Phe Leu Thr Ala Gly Phe Thr Ser Leu Gln Leu Val Thr 
    930                 935                 940                 


Gln Met Thr Ser Glu Asp Leu Leu Arg Ile Gly Ile Thr Leu Ala Gly 
945                 950                 955                 960 


His Gln Lys Lys Ile Leu Asn Ser Ile His Ser Met Arg Val Gln Ile 
                965                 970                 975     


Ser Gln Ser Pro Thr Ala Met Ala 
            980                 


<210>  425
<211>  1055
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Ala Leu Arg Arg Leu Gly Ala Ala Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Ala Ala Val Glu Glu Thr Leu Met Asp Ser Thr Thr Ala Thr Ala Glu 
            20                  25                  30          


Leu Gly Trp Met Val His Pro Pro Ser Gly Trp Glu Glu Val Ser Gly 
        35                  40                  45              


Tyr Asp Glu Asn Met Asn Thr Ile Arg Thr Tyr Gln Val Cys Asn Val 
    50                  55                  60                  


Phe Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Lys Phe Ile Arg Arg 
65                  70                  75                  80  


Arg Gly Ala His Arg Ile His Val Glu Met Lys Phe Ser Val Arg Asp 
                85                  90                  95      


Cys Ser Ser Ile Pro Ser Val Pro Gly Ser Cys Lys Glu Thr Phe Asn 
            100                 105                 110         


Leu Tyr Tyr Tyr Glu Ala Asp Phe Asp Ser Ala Thr Lys Thr Phe Pro 
        115                 120                 125             


Asn Trp Met Glu Asn Pro Trp Val Lys Val Asp Thr Ile Ala Ala Asp 
    130                 135                 140                 


Glu Ser Phe Ser Gln Val Asp Leu Gly Gly Arg Val Met Lys Ile Asn 
145                 150                 155                 160 


Thr Glu Val Arg Ser Phe Gly Pro Val Ser Arg Ser Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Tyr Gly Gly Cys Met Ser Leu Ile Ala Val Arg Val 
            180                 185                 190         


Phe Tyr Arg Lys Cys Pro Arg Ile Ile Gln Asn Gly Ala Ile Phe Gln 
        195                 200                 205             


Glu Thr Leu Ser Gly Ala Glu Ser Thr Ser Leu Val Ala Ala Arg Gly 
    210                 215                 220                 


Ser Cys Ile Ala Asn Ala Glu Glu Val Asp Val Pro Ile Lys Leu Tyr 
225                 230                 235                 240 


Cys Asn Gly Asp Gly Glu Trp Leu Val Pro Ile Gly Arg Cys Met Cys 
                245                 250                 255     


Lys Ala Gly Phe Glu Ala Val Glu Asn Gly Thr Val Cys Arg Gly Cys 
            260                 265                 270         


Pro Ser Gly Thr Phe Lys Ala Asn Gln Gly Asp Glu Ala Cys Thr His 
        275                 280                 285             


Cys Pro Ile Asn Ser Arg Thr Thr Ser Glu Gly Ala Thr Asn Cys Val 
    290                 295                 300                 


Cys Arg Asn Gly Tyr Tyr Arg Ala Asp Leu Asp Pro Leu Asp Met Pro 
305                 310                 315                 320 


Cys Thr Thr Ile Pro Ser Ala Pro Gln Ala Val Ile Ser Ser Val Asn 
                325                 330                 335     


Glu Thr Ser Leu Met Leu Glu Trp Thr Pro Pro Arg Asp Ser Gly Gly 
            340                 345                 350         


Arg Glu Asp Leu Val Tyr Asn Ile Ile Cys Lys Ser Cys Gly Ser Gly 
        355                 360                 365             


Arg Gly Ala Cys Thr Arg Cys Gly Asp Asn Val Gln Tyr Ala Pro Arg 
    370                 375                 380                 


Gln Leu Gly Leu Thr Glu Pro Arg Ile Tyr Ile Ser Asp Leu Leu Ala 
385                 390                 395                 400 


His Thr Gln Tyr Thr Phe Glu Ile Gln Ala Val Asn Gly Val Thr Asp 
                405                 410                 415     


Gln Ser Pro Phe Ser Pro Gln Phe Ala Ser Val Asn Ile Thr Thr Asn 
            420                 425                 430         


Gln Ala Ala Pro Ser Ala Val Ser Ile Met His Gln Val Ser Arg Thr 
        435                 440                 445             


Val Asp Ser Ile Thr Leu Ser Trp Ser Gln Pro Asp Gln Pro Asn Gly 
    450                 455                 460                 


Val Ile Leu Asp Tyr Glu Leu Gln Tyr Tyr Glu Lys Glu Leu Ser Glu 
465                 470                 475                 480 


Tyr Asn Ala Thr Ala Ile Lys Ser Pro Thr Asn Thr Val Thr Val Gln 
                485                 490                 495     


Gly Leu Lys Ala Gly Ala Ile Tyr Val Phe Gln Val Arg Ala Arg Thr 
            500                 505                 510         


Val Ala Gly Tyr Gly Arg Tyr Ser Gly Lys Met Tyr Phe Gln Thr Met 
        515                 520                 525             


Thr Glu Ala Glu Tyr Gln Thr Ser Ile Gln Glu Lys Leu Pro Leu Ile 
    530                 535                 540                 


Ile Gly Ser Ser Ala Ala Gly Leu Val Phe Leu Ile Ala Val Val Val 
545                 550                 555                 560 


Ile Ala Ile Val Cys Asn Arg Arg Gly Phe Glu Arg Ala Asp Ser Glu 
                565                 570                 575     


Tyr Thr Asp Lys Leu Gln His Tyr Thr Ser Gly His Met Thr Pro Gly 
            580                 585                 590         


Met Lys Ile Tyr Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala 
        595                 600                 605             


Val Arg Glu Phe Ala Lys Glu Ile Asp Ile Ser Cys Val Lys Ile Glu 
    610                 615                 620                 


Gln Val Ile Gly Ala Gly Glu Phe Gly Glu Val Cys Ser Gly His Leu 
625                 630                 635                 640 


Lys Leu Pro Gly Lys Arg Glu Ile Phe Val Ala Ile Lys Thr Leu Lys 
                645                 650                 655     


Ser Gly Tyr Thr Glu Lys Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser 
            660                 665                 670         


Ile Met Gly Gln Phe Asp His Pro Asn Val Ile His Leu Glu Gly Val 
        675                 680                 685             


Val Thr Lys Ser Thr Pro Val Met Ile Ile Thr Glu Phe Met Glu Asn 
    690                 695                 700                 


Gly Ser Leu Asp Ser Phe Leu Arg Gln Asn Asp Gly Gln Phe Thr Val 
705                 710                 715                 720 


Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr 
                725                 730                 735     


Leu Ala Asp Met Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile 
            740                 745                 750         


Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser 
        755                 760                 765             


Arg Phe Leu Glu Asp Asp Thr Ser Asp Pro Thr Tyr Thr Ser Ala Leu 
    770                 775                 780                 


Gly Gly Lys Ile Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Gln Tyr 
785                 790                 795                 800 


Arg Lys Phe Thr Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met 
                805                 810                 815     


Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Thr Asn 
            820                 825                 830         


Gln Asp Val Ile Asn Ala Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro 
        835                 840                 845             


Met Asp Cys Pro Ser Ala Leu His Gln Leu Met Leu Asp Cys Trp Gln 
    850                 855                 860                 


Lys Asp Arg Asn His Arg Pro Lys Phe Gly Gln Ile Val Asn Thr Leu 
865                 870                 875                 880 


Asp Lys Met Ile Arg Asn Pro Asn Ser Leu Lys Ala Met Ala Pro Leu 
                885                 890                 895     


Ser Ser Gly Ile Asn Leu Pro Leu Leu Asp Arg Thr Ile Pro Asp Tyr 
            900                 905                 910         


Thr Ser Phe Asn Thr Val Asp Glu Trp Leu Glu Ala Ile Lys Met Gly 
        915                 920                 925             


Gln Tyr Lys Glu Ser Phe Ala Asn Ala Gly Phe Thr Ser Phe Asp Val 
    930                 935                 940                 


Val Ser Gln Met Met Met Glu Asp Ile Leu Arg Val Gly Val Thr Leu 
945                 950                 955                 960 


Ala Gly His Gln Lys Lys Ile Leu Asn Ser Ile Gln Val Met Arg Ala 
                965                 970                 975     


Gln Met Asn Gln Ile Gln Ser Val Glu Gly Gln Pro Leu Ala Arg Arg 
            980                 985                 990         


Pro Arg Ala Thr Gly Arg Thr Lys  Arg Cys Gln Pro Arg  Asp Val Thr 
        995                 1000                 1005             


Lys Lys  Thr Cys Asn Ser Asn  Asp Gly Lys Lys Lys  Gly Met Gly 
    1010                 1015                 1020             


Lys Lys  Lys Thr Asp Pro Gly  Arg Gly Arg Glu Ile  Gln Gly Ile 
    1025                 1030                 1035             


Phe Phe  Lys Glu Asp Ser His  Lys Glu Ser Asn Asp  Cys Ser Cys 
    1040                 1045                 1050             


Gly Gly  
    1055 


<210>  426
<211>  998
<212>  PRT
<213>  Homo sapiens

<400>  426

Met Ala Arg Ala Arg Pro Pro Pro Pro Pro Ser Pro Pro Pro Gly Leu 
1               5                   10                  15      


Leu Pro Leu Leu Pro Pro Leu Leu Leu Leu Pro Leu Leu Leu Leu Pro 
            20                  25                  30          


Ala Gly Cys Arg Ala Leu Glu Glu Thr Leu Met Asp Thr Lys Trp Val 
        35                  40                  45              


Thr Ser Glu Leu Ala Trp Thr Ser His Pro Glu Ser Gly Trp Glu Glu 
    50                  55                  60                  


Val Ser Gly Tyr Asp Glu Ala Met Asn Pro Ile Arg Thr Tyr Gln Val 
65                  70                  75                  80  


Cys Asn Val Arg Glu Ser Ser Gln Asn Asn Trp Leu Arg Thr Gly Phe 
                85                  90                  95      


Ile Trp Arg Arg Asp Val Gln Arg Val Tyr Val Glu Leu Lys Phe Thr 
            100                 105                 110         


Val Arg Asp Cys Asn Ser Ile Pro Asn Ile Pro Gly Ser Cys Lys Glu 
        115                 120                 125             


Thr Phe Asn Leu Phe Tyr Tyr Glu Ala Asp Ser Asp Val Ala Ser Ala 
    130                 135                 140                 


Ser Ser Pro Phe Trp Met Glu Asn Pro Tyr Val Lys Val Asp Thr Ile 
145                 150                 155                 160 


Ala Pro Asp Glu Ser Phe Ser Arg Leu Asp Ala Gly Arg Val Asn Thr 
                165                 170                 175     


Lys Val Arg Ser Phe Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu Ala 
            180                 185                 190         


Phe Gln Asp Gln Gly Ala Cys Met Ser Leu Ile Ser Val Arg Ala Phe 
        195                 200                 205             


Tyr Lys Lys Cys Ala Ser Thr Thr Ala Gly Phe Ala Leu Phe Pro Glu 
    210                 215                 220                 


Thr Leu Thr Gly Ala Glu Pro Thr Ser Leu Val Ile Ala Pro Gly Thr 
225                 230                 235                 240 


Cys Ile Pro Asn Ala Val Glu Val Ser Val Pro Leu Lys Leu Tyr Cys 
                245                 250                 255     


Asn Gly Asp Gly Glu Trp Met Val Pro Val Gly Ala Cys Thr Cys Ala 
            260                 265                 270         


Thr Gly His Glu Pro Ala Ala Lys Glu Ser Gln Cys Arg Pro Cys Pro 
        275                 280                 285             


Pro Gly Ser Tyr Lys Ala Lys Gln Gly Glu Gly Pro Cys Leu Pro Cys 
    290                 295                 300                 


Pro Pro Asn Ser Arg Thr Thr Ser Pro Ala Ala Ser Ile Cys Thr Cys 
305                 310                 315                 320 


His Asn Asn Phe Tyr Arg Ala Asp Ser Asp Ser Ala Asp Ser Ala Cys 
                325                 330                 335     


Thr Thr Val Pro Ser Pro Pro Arg Gly Val Ile Ser Asn Val Asn Glu 
            340                 345                 350         


Thr Ser Leu Ile Leu Glu Trp Ser Glu Pro Arg Asp Leu Gly Gly Arg 
        355                 360                 365             


Asp Asp Leu Leu Tyr Asn Val Ile Cys Lys Lys Cys His Gly Ala Gly 
    370                 375                 380                 


Gly Ala Ser Ala Cys Ser Arg Cys Asp Asp Asn Val Glu Phe Val Pro 
385                 390                 395                 400 


Arg Gln Leu Gly Leu Thr Glu Arg Arg Val His Ile Ser His Leu Leu 
                405                 410                 415     


Ala His Thr Arg Tyr Thr Phe Glu Val Gln Ala Val Asn Gly Val Ser 
            420                 425                 430         


Gly Lys Ser Pro Leu Pro Pro Arg Tyr Ala Ala Val Asn Ile Thr Thr 
        435                 440                 445             


Asn Gln Ala Ala Pro Ser Glu Val Pro Thr Leu Arg Leu His Ser Ser 
    450                 455                 460                 


Ser Gly Ser Ser Leu Thr Leu Ser Trp Ala Pro Pro Glu Arg Pro Asn 
465                 470                 475                 480 


Gly Val Ile Leu Asp Tyr Glu Met Lys Tyr Phe Glu Lys Ser Glu Gly 
                485                 490                 495     


Ile Ala Ser Thr Val Thr Ser Gln Met Asn Ser Val Gln Leu Asp Gly 
            500                 505                 510         


Leu Arg Pro Asp Ala Arg Tyr Val Val Gln Val Arg Ala Arg Thr Val 
        515                 520                 525             


Ala Gly Tyr Gly Gln Tyr Ser Arg Pro Ala Glu Phe Glu Thr Thr Ser 
    530                 535                 540                 


Glu Arg Gly Ser Gly Ala Gln Gln Leu Gln Glu Gln Leu Pro Leu Ile 
545                 550                 555                 560 


Val Gly Ser Ala Thr Ala Gly Leu Val Phe Val Val Ala Val Val Val 
                565                 570                 575     


Ile Ala Ile Val Cys Leu Arg Lys Gln Arg His Gly Ser Asp Ser Glu 
            580                 585                 590         


Tyr Thr Glu Lys Leu Gln Gln Tyr Ile Ala Pro Gly Met Lys Val Tyr 
        595                 600                 605             


Ile Asp Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe 
    610                 615                 620                 


Ala Lys Glu Ile Asp Val Ser Cys Val Lys Ile Glu Glu Val Ile Gly 
625                 630                 635                 640 


Ala Gly Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Gln Pro Gly 
                645                 650                 655     


Arg Arg Glu Val Phe Val Ala Ile Lys Thr Leu Lys Val Gly Tyr Thr 
            660                 665                 670         


Glu Arg Gln Arg Arg Asp Phe Leu Ser Glu Ala Ser Ile Met Gly Gln 
        675                 680                 685             


Phe Asp His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Ser 
    690                 695                 700                 


Arg Pro Val Met Ile Leu Thr Glu Phe Met Glu Asn Cys Ala Leu Asp 
705                 710                 715                 720 


Ser Phe Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val 
                725                 730                 735     


Gly Met Leu Arg Gly Ile Ala Ala Gly Met Lys Tyr Leu Ser Glu Met 
            740                 745                 750         


Asn Tyr Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser 
        755                 760                 765             


Asn Leu Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu 
    770                 775                 780                 


Asp Asp Pro Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile 
785                 790                 795                 800 


Pro Ile Arg Trp Thr Ala Pro Glu Ala Ile Ala Tyr Arg Lys Phe Thr 
                805                 810                 815     


Ser Ala Ser Asp Val Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met 
            820                 825                 830         


Ser Tyr Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile 
        835                 840                 845             


Asn Ala Val Glu Gln Asp Tyr Arg Leu Pro Pro Pro Met Asp Cys Pro 
    850                 855                 860                 


Thr Ala Leu His Gln Leu Met Leu Asp Cys Trp Val Arg Asp Arg Asn 
865                 870                 875                 880 


Leu Arg Pro Lys Phe Ser Gln Ile Val Asn Thr Leu Asp Lys Leu Ile 
                885                 890                 895     


Arg Asn Ala Ala Ser Leu Lys Val Ile Ala Ser Ala Gln Ser Gly Met 
            900                 905                 910         


Ser Gln Pro Leu Leu Asp Arg Thr Val Pro Asp Tyr Thr Thr Phe Thr 
        915                 920                 925             


Thr Val Gly Asp Trp Leu Asp Ala Ile Lys Met Gly Arg Tyr Lys Glu 
    930                 935                 940                 


Ser Phe Val Ser Ala Gly Phe Ala Ser Phe Asp Leu Val Ala Gln Met 
945                 950                 955                 960 


Thr Ala Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln 
                965                 970                 975     


Lys Lys Ile Leu Ser Ser Ile Gln Asp Met Arg Leu Gln Met Asn Gln 
            980                 985                 990         


Thr Leu Pro Val Gln Val 
        995             


<210>  427
<211>  987
<212>  PRT
<213>  Homo sapiens

<400>  427

Met Glu Leu Arg Val Leu Leu Cys Trp Ala Ser Leu Ala Ala Ala Leu 
1               5                   10                  15      


Glu Glu Thr Leu Leu Asn Thr Lys Leu Glu Thr Ala Asp Leu Lys Trp 
            20                  25                  30          


Val Thr Phe Pro Gln Val Asp Gly Gln Trp Glu Glu Leu Ser Gly Leu 
        35                  40                  45              


Asp Glu Glu Gln His Ser Val Arg Thr Tyr Glu Val Cys Asp Val Gln 
    50                  55                  60                  


Arg Ala Pro Gly Gln Ala His Trp Leu Arg Thr Gly Trp Val Pro Arg 
65                  70                  75                  80  


Arg Gly Ala Val His Val Tyr Ala Thr Leu Arg Phe Thr Met Leu Glu 
                85                  90                  95      


Cys Leu Ser Leu Pro Arg Ala Gly Arg Ser Cys Lys Glu Thr Phe Thr 
            100                 105                 110         


Val Phe Tyr Tyr Glu Ser Asp Ala Asp Thr Ala Thr Ala Leu Thr Pro 
        115                 120                 125             


Ala Trp Met Glu Asn Pro Tyr Ile Lys Val Asp Thr Val Ala Ala Glu 
    130                 135                 140                 


His Leu Thr Arg Lys Arg Pro Gly Ala Glu Ala Thr Gly Lys Val Asn 
145                 150                 155                 160 


Val Lys Thr Leu Arg Leu Gly Pro Leu Ser Lys Ala Gly Phe Tyr Leu 
                165                 170                 175     


Ala Phe Gln Asp Gln Gly Ala Cys Met Ala Leu Leu Ser Leu His Leu 
            180                 185                 190         


Phe Tyr Lys Lys Cys Ala Gln Leu Thr Val Asn Leu Thr Arg Phe Pro 
        195                 200                 205             


Glu Thr Val Pro Arg Glu Leu Val Val Pro Val Ala Gly Ser Cys Val 
    210                 215                 220                 


Val Asp Ala Val Pro Ala Pro Gly Pro Ser Pro Ser Leu Tyr Cys Arg 
225                 230                 235                 240 


Glu Asp Gly Gln Trp Ala Glu Gln Pro Val Thr Gly Cys Ser Cys Ala 
                245                 250                 255     


Pro Gly Phe Glu Ala Ala Glu Gly Asn Thr Lys Cys Arg Ala Cys Ala 
            260                 265                 270         


Gln Gly Thr Phe Lys Pro Leu Ser Gly Glu Gly Ser Cys Gln Pro Cys 
        275                 280                 285             


Pro Ala Asn Ser His Ser Asn Thr Ile Gly Ser Ala Val Cys Gln Cys 
    290                 295                 300                 


Arg Val Gly Tyr Phe Arg Ala Arg Thr Asp Pro Arg Gly Ala Pro Cys 
305                 310                 315                 320 


Thr Thr Pro Pro Ser Ala Pro Arg Ser Val Val Ser Arg Leu Asn Gly 
                325                 330                 335     


Ser Ser Leu His Leu Glu Trp Ser Ala Pro Leu Glu Ser Gly Gly Arg 
            340                 345                 350         


Glu Asp Leu Thr Tyr Ala Leu Arg Cys Arg Glu Cys Arg Pro Gly Gly 
        355                 360                 365             


Ser Cys Ala Pro Cys Gly Gly Asp Leu Thr Phe Asp Pro Gly Pro Arg 
    370                 375                 380                 


Asp Leu Val Glu Pro Trp Val Val Val Arg Gly Leu Arg Pro Asp Phe 
385                 390                 395                 400 


Thr Tyr Thr Phe Glu Val Thr Ala Leu Asn Gly Val Ser Ser Leu Ala 
                405                 410                 415     


Thr Gly Pro Val Pro Phe Glu Pro Val Asn Val Thr Thr Asp Arg Glu 
            420                 425                 430         


Val Pro Pro Ala Val Ser Asp Ile Arg Val Thr Arg Ser Ser Pro Ser 
        435                 440                 445             


Ser Leu Ser Leu Ala Trp Ala Val Pro Arg Ala Pro Ser Gly Ala Val 
    450                 455                 460                 


Leu Asp Tyr Glu Val Lys Tyr His Glu Lys Gly Ala Glu Gly Pro Ser 
465                 470                 475                 480 


Ser Val Arg Phe Leu Lys Thr Ser Glu Asn Arg Ala Glu Leu Arg Gly 
                485                 490                 495     


Leu Lys Arg Gly Ala Ser Tyr Leu Val Gln Val Arg Ala Arg Ser Glu 
            500                 505                 510         


Ala Gly Tyr Gly Pro Phe Gly Gln Glu His His Ser Gln Thr Gln Leu 
        515                 520                 525             


Asp Glu Ser Glu Gly Trp Arg Glu Gln Leu Ala Leu Ile Ala Gly Thr 
    530                 535                 540                 


Ala Val Val Gly Val Val Leu Val Leu Val Val Ile Val Val Ala Val 
545                 550                 555                 560 


Leu Cys Leu Arg Lys Gln Ser Asn Gly Arg Glu Ala Glu Tyr Ser Asp 
                565                 570                 575     


Lys His Gly Gln Tyr Leu Ile Gly His Gly Thr Lys Val Tyr Ile Asp 
            580                 585                 590         


Pro Phe Thr Tyr Glu Asp Pro Asn Glu Ala Val Arg Glu Phe Ala Lys 
        595                 600                 605             


Glu Ile Asp Val Ser Tyr Val Lys Ile Glu Glu Val Ile Gly Ala Gly 
    610                 615                 620                 


Glu Phe Gly Glu Val Cys Arg Gly Arg Leu Lys Ala Pro Gly Lys Lys 
625                 630                 635                 640 


Glu Ser Cys Val Ala Ile Lys Thr Leu Lys Gly Gly Tyr Thr Glu Arg 
                645                 650                 655     


Gln Arg Arg Glu Phe Leu Ser Glu Ala Ser Ile Met Gly Gln Phe Glu 
            660                 665                 670         


His Pro Asn Ile Ile Arg Leu Glu Gly Val Val Thr Asn Ser Met Pro 
        675                 680                 685             


Val Met Ile Leu Thr Glu Phe Met Glu Asn Gly Ala Leu Asp Ser Phe 
    690                 695                 700                 


Leu Arg Leu Asn Asp Gly Gln Phe Thr Val Ile Gln Leu Val Gly Met 
705                 710                 715                 720 


Leu Arg Gly Ile Ala Ser Gly Met Arg Tyr Leu Ala Glu Met Ser Tyr 
                725                 730                 735     


Val His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Asn Ser Asn Leu 
            740                 745                 750         


Val Cys Lys Val Ser Asp Phe Gly Leu Ser Arg Phe Leu Glu Glu Asn 
        755                 760                 765             


Ser Ser Asp Pro Thr Tyr Thr Ser Ser Leu Gly Gly Lys Ile Pro Ile 
    770                 775                 780                 


Arg Trp Thr Ala Pro Glu Ala Ile Ala Phe Arg Lys Phe Thr Ser Ala 
785                 790                 795                 800 


Ser Asp Ala Trp Ser Tyr Gly Ile Val Met Trp Glu Val Met Ser Phe 
                805                 810                 815     


Gly Glu Arg Pro Tyr Trp Asp Met Ser Asn Gln Asp Val Ile Asn Ala 
            820                 825                 830         


Ile Glu Gln Asp Tyr Arg Leu Pro Pro Pro Pro Asp Cys Pro Thr Ser 
        835                 840                 845             


Leu His Gln Leu Met Leu Asp Cys Trp Gln Lys Asp Arg Asn Ala Arg 
    850                 855                 860                 


Pro Arg Phe Pro Gln Val Val Ser Ala Leu Asp Lys Met Ile Arg Asn 
865                 870                 875                 880 


Pro Ala Ser Leu Lys Ile Val Ala Arg Glu Asn Gly Gly Ala Ser His 
                885                 890                 895     


Pro Leu Leu Asp Gln Arg Gln Pro His Tyr Ser Ala Phe Gly Ser Val 
            900                 905                 910         


Gly Glu Trp Leu Arg Ala Ile Lys Met Gly Arg Tyr Glu Glu Ser Phe 
        915                 920                 925             


Ala Ala Ala Gly Phe Gly Ser Phe Glu Leu Val Ser Gln Ile Ser Ala 
    930                 935                 940                 


Glu Asp Leu Leu Arg Ile Gly Val Thr Leu Ala Gly His Gln Lys Lys 
945                 950                 955                 960 


Ile Leu Ala Ser Val Gln His Met Lys Ser Gln Ala Lys Pro Gly Thr 
                965                 970                 975     


Pro Gly Gly Thr Gly Gly Pro Ala Pro Gln Tyr 
            980                 985         


<210>  428
<211>  1022
<212>  PRT
<213>  Homo sapiens

<400>  428

Met Ala Thr Glu Gly Ala Ala Gln Leu Gly Asn Arg Val Ala Gly Met 
1               5                   10                  15      


Val Cys Ser Leu Trp Val Leu Leu Leu Val Ser Ser Val Leu Ala Leu 
            20                  25                  30          


Glu Glu Val Leu Leu Asp Thr Thr Gly Glu Thr Ser Glu Ile Gly Trp 
        35                  40                  45              


Leu Thr Tyr Pro Pro Gly Gly Trp Asp Glu Val Ser Val Leu Asp Asp 
    50                  55                  60                  


Gln Arg Arg Leu Thr Arg Thr Phe Glu Ala Cys His Val Ala Gly Ala 
65                  70                  75                  80  


Pro Pro Gly Thr Gly Gln Asp Asn Trp Leu Gln Thr His Phe Val Glu 
                85                  90                  95      


Arg Arg Gly Ala Gln Arg Ala His Ile Arg Leu His Phe Ser Val Arg 
            100                 105                 110         


Ala Cys Ser Ser Leu Gly Val Ser Gly Gly Thr Cys Arg Glu Thr Phe 
        115                 120                 125             


Thr Leu Tyr Tyr Arg Gln Ala Glu Glu Pro Asp Ser Pro Asp Ser Val 
    130                 135                 140                 


Ser Ser Trp His Leu Lys Arg Trp Thr Lys Val Asp Thr Ile Ala Ala 
145                 150                 155                 160 


Asp Glu Ser Phe Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser 
                165                 170                 175     


Ser Ala Ala Trp Ala Val Gly Pro His Gly Ala Gly Gln Arg Ala Gly 
            180                 185                 190         


Leu Gln Leu Asn Val Lys Glu Arg Ser Phe Gly Pro Leu Thr Gln Arg 
        195                 200                 205             


Gly Phe Tyr Val Ala Phe Gln Asp Thr Gly Ala Cys Leu Ala Leu Val 
    210                 215                 220                 


Ala Val Arg Leu Phe Ser Tyr Thr Cys Pro Ala Val Leu Arg Ser Phe 
225                 230                 235                 240 


Ala Ser Phe Pro Glu Thr Gln Ala Ser Gly Ala Gly Gly Ala Ser Leu 
                245                 250                 255     


Val Ala Ala Val Gly Thr Cys Val Ala His Ala Glu Pro Glu Glu Asp 
            260                 265                 270         


Gly Val Gly Gly Gln Ala Gly Gly Ser Pro Pro Arg Leu His Cys Asn 
        275                 280                 285             


Gly Glu Gly Lys Trp Met Val Ala Val Gly Gly Cys Arg Cys Gln Pro 
    290                 295                 300                 


Gly Tyr Gln Pro Ala Arg Gly Asp Lys Ala Cys Gln Ala Cys Pro Arg 
305                 310                 315                 320 


Gly Leu Tyr Lys Ala Ser Ala Gly Asn Ala Pro Cys Ser Pro Cys Pro 
                325                 330                 335     


Ala Arg Ser His Ala Pro Asn Pro Ala Ala Pro Val Cys Pro Cys Leu 
            340                 345                 350         


Glu Gly Phe Tyr Arg Ala Ser Ser Asp Pro Pro Glu Ala Pro Cys Thr 
        355                 360                 365             


Gly Pro Pro Ser Ala Pro Gln Glu Leu Trp Phe Glu Val Gln Gly Ser 
    370                 375                 380                 


Ala Leu Met Leu His Trp Arg Leu Pro Arg Glu Leu Gly Gly Arg Gly 
385                 390                 395                 400 


Asp Leu Leu Phe Asn Val Val Cys Lys Glu Cys Glu Gly Arg Gln Glu 
                405                 410                 415     


Pro Ala Ser Gly Gly Gly Gly Thr Cys His Arg Cys Arg Asp Glu Val 
            420                 425                 430         


His Phe Asp Pro Arg Gln Arg Gly Leu Thr Glu Ser Arg Val Leu Val 
        435                 440                 445             


Gly Gly Leu Arg Ala His Val Pro Tyr Ile Leu Glu Val Gln Ala Val 
    450                 455                 460                 


Asn Gly Val Ser Glu Leu Ser Pro Asp Pro Pro Gln Ala Ala Ala Ile 
465                 470                 475                 480 


Asn Val Ser Thr Ser His Glu Val Pro Ser Ala Val Pro Val Val His 
                485                 490                 495     


Gln Val Ser Arg Ala Ser Asn Ser Ile Thr Val Ser Trp Pro Gln Pro 
            500                 505                 510         


Asp Gln Thr Asn Gly Asn Ile Leu Asp Tyr Gln Leu Arg Tyr Tyr Asp 
        515                 520                 525             


Gln Ala Glu Asp Glu Ser His Ser Phe Thr Leu Thr Ser Glu Thr Asn 
    530                 535                 540                 


Thr Ala Thr Val Thr Gln Leu Ser Pro Gly His Ile Tyr Gly Phe Gln 
545                 550                 555                 560 


Val Arg Ala Arg Thr Ala Ala Gly His Gly Pro Tyr Gly Gly Lys Val 
                565                 570                 575     


Tyr Phe Gln Thr Leu Pro Gln Gly Glu Leu Ser Ser Gln Leu Pro Glu 
            580                 585                 590         


Arg Leu Ser Leu Val Ile Gly Ser Ile Leu Gly Ala Leu Ala Phe Leu 
        595                 600                 605             


Leu Leu Ala Ala Ile Thr Val Leu Ala Val Val Phe Gln Arg Lys Arg 
    610                 615                 620                 


Arg Gly Thr Gly Tyr Thr Glu Gln Leu Gln Gln Tyr Ser Ser Pro Gly 
625                 630                 635                 640 


Leu Gly Val Lys Tyr Tyr Ile Asp Pro Ser Thr Tyr Glu Asp Pro Cys 
                645                 650                 655     


Gln Ala Ile Arg Glu Leu Ala Arg Glu Val Asp Pro Ala Tyr Ile Lys 
            660                 665                 670         


Ile Glu Glu Val Ile Gly Thr Gly Ser Phe Gly Glu Val Arg Gln Gly 
        675                 680                 685             


Arg Leu Gln Pro Arg Gly Arg Arg Glu Gln Thr Val Ala Ile Gln Ala 
    690                 695                 700                 


Leu Trp Ala Gly Gly Ala Glu Ser Leu Gln Met Thr Phe Leu Gly Arg 
705                 710                 715                 720 


Ala Ala Val Leu Gly Gln Phe Gln His Pro Asn Ile Leu Arg Leu Glu 
                725                 730                 735     


Gly Val Val Thr Lys Ser Arg Pro Leu Met Val Leu Thr Glu Phe Met 
            740                 745                 750         


Glu Leu Gly Pro Leu Asp Ser Phe Leu Arg Gln Arg Glu Gly Gln Phe 
        755                 760                 765             


Ser Ser Leu Gln Leu Val Ala Met Gln Arg Gly Val Ala Ala Ala Met 
    770                 775                 780                 


Gln Tyr Leu Ser Ser Phe Ala Phe Val His Arg Ser Leu Ser Ala His 
785                 790                 795                 800 


Ser Val Leu Val Asn Ser His Leu Val Cys Lys Val Ala Arg Leu Gly 
                805                 810                 815     


His Ser Pro Gln Gly Pro Ser Cys Leu Leu Arg Trp Ala Ala Pro Glu 
            820                 825                 830         


Val Ile Ala His Gly Lys His Thr Thr Ser Ser Asp Val Trp Ser Phe 
        835                 840                 845             


Gly Ile Leu Met Trp Glu Val Met Ser Tyr Gly Glu Arg Pro Tyr Trp 
    850                 855                 860                 


Asp Met Ser Glu Gln Glu Val Leu Asn Ala Ile Glu Gln Glu Phe Arg 
865                 870                 875                 880 


Leu Pro Pro Pro Pro Gly Cys Pro Pro Gly Leu His Leu Leu Met Leu 
                885                 890                 895     


Asp Thr Trp Gln Lys Asp Arg Ala Arg Arg Pro His Phe Asp Gln Leu 
            900                 905                 910         


Val Ala Ala Phe Asp Lys Met Ile Arg Lys Pro Asp Thr Leu Gln Ala 
        915                 920                 925             


Gly Gly Asp Pro Gly Glu Arg Pro Ser Gln Ala Leu Leu Thr Pro Val 
    930                 935                 940                 


Ala Leu Asp Phe Pro Cys Leu Asp Ser Pro Gln Ala Trp Leu Ser Ala 
945                 950                 955                 960 


Ile Gly Leu Glu Cys Tyr Gln Asp Asn Phe Ser Lys Phe Gly Leu Cys 
                965                 970                 975     


Thr Phe Ser Asp Val Ala Gln Leu Ser Leu Glu Asp Leu Pro Ala Leu 
            980                 985                 990         


Gly Ile Thr Leu Ala Gly His Gln  Lys Lys Leu Leu His  His Ile Gln 
        995                 1000                 1005             


Leu Leu  Gln Gln His Leu Arg  Gln Gln Gly Ser Val  Glu Val 
    1010                 1015                 1020         


<210>  429
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  429

Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys 
            20                  25                  30          


Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His 
        35                  40                  45              


Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr 
    50                  55                  60                  


Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val 
65                  70                  75                  80  


Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu 
                85                  90                  95      


Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr 
            100                 105                 110         


Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro 
        115                 120                 125             


Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser 
    130                 135                 140                 


Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln 
145                 150                 155                 160 


Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn 
                165                 170                 175     


Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys 
            180                 185                 190         


His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser 
        195                 200                 205             


Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys 
    210                 215                 220                 


Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys 
225                 230                 235                 240 


Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu 
                245                 250                 255     


His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val 
            260                 265                 270         


Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg 
        275                 280                 285             


Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu 
    290                 295                 300                 


Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln 
305                 310                 315                 320 


Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys 
                325                 330                 335     


Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu 
            340                 345                 350         


Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys 
        355                 360                 365             


Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp 
    370                 375                 380                 


Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe 
385                 390                 395                 400 


Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro 
                405                 410                 415     


Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg 
            420                 425                 430         


Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu 
        435                 440                 445             


Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly 
    450                 455                 460                 


Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val 
465                 470                 475                 480 


Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr 
                485                 490                 495     


Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His 
            500                 505                 510         


Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys 
        515                 520                 525             


Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys 
    530                 535                 540                 


Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys 
545                 550                 555                 560 


Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys 
                565                 570                 575     


Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp 
            580                 585                 590         


Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu 
        595                 600                 605             


Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln 
    610                 615                 620                 


Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys 
625                 630                 635                 640 


Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser 
                645                 650                 655     


Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly 
            660                 665                 670         


Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg 
        675                 680                 685             


Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly 
    690                 695                 700                 


Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu 
705                 710                 715                 720 


Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
                725                 730                 735     


Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile 
            740                 745                 750         


Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu 
        755                 760                 765             


Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg 
    770                 775                 780                 


Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu 
785                 790                 795                 800 


Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg 
                805                 810                 815     


Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly 
            820                 825                 830         


Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala 
        835                 840                 845             


Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe 
    850                 855                 860                 


Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp 
865                 870                 875                 880 


Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg 
                885                 890                 895     


Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val 
            900                 905                 910         


Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala 
        915                 920                 925             


Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro 
    930                 935                 940                 


Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met 
945                 950                 955                 960 


Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe 
                965                 970                 975     


Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu 
            980                 985                 990         


Asp Leu Gly Pro Ala Ser Pro Leu  Asp Ser Thr Phe Tyr  Arg Ser Leu 
        995                 1000                 1005             


Leu Glu  Asp Asp Asp Met Gly  Asp Leu Val Asp Ala  Glu Glu Tyr 
    1010                 1015                 1020             


Leu Val  Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
    1025                 1030                 1035             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1040                 1045                 1050             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1055                 1060                 1065             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1070                 1075                 1080             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1085                 1090                 1095             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1100                 1105                 1110             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1115                 1120                 1125             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1130                 1135                 1140             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1145                 1150                 1155             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1160                 1165                 1170             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1175                 1180                 1185             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1190                 1195                 1200             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1205                 1210                 1215             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1220                 1225                 1230             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1235                 1240                 1245             


Leu Gly  Leu Asp Val Pro Val  
    1250                 1255 


<210>  430
<211>  1342
<212>  PRT
<213>  Homo sapiens

<400>  430

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  431
<211>  1308
<212>  PRT
<213>  Homo sapiens

<400>  431

Met Lys Pro Ala Thr Gly Leu Trp Val Trp Val Ser Leu Leu Val Ala 
1               5                   10                  15      


Ala Gly Thr Val Gln Pro Ser Asp Ser Gln Ser Val Cys Ala Gly Thr 
            20                  25                  30          


Glu Asn Lys Leu Ser Ser Leu Ser Asp Leu Glu Gln Gln Tyr Arg Ala 
        35                  40                  45              


Leu Arg Lys Tyr Tyr Glu Asn Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Thr Ser Ile Glu His Asn Arg Asp Leu Ser Phe Leu Arg Ser Val 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Leu Asn Gln Phe Arg Tyr 
                85                  90                  95      


Leu Pro Leu Glu Asn Leu Arg Ile Ile Arg Gly Thr Lys Leu Tyr Glu 
            100                 105                 110         


Asp Arg Tyr Ala Leu Ala Ile Phe Leu Asn Tyr Arg Lys Asp Gly Asn 
        115                 120                 125             


Phe Gly Leu Gln Glu Leu Gly Leu Lys Asn Leu Thr Glu Ile Leu Asn 
    130                 135                 140                 


Gly Gly Val Tyr Val Asp Gln Asn Lys Phe Leu Cys Tyr Ala Asp Thr 
145                 150                 155                 160 


Ile His Trp Gln Asp Ile Val Arg Asn Pro Trp Pro Ser Asn Leu Thr 
                165                 170                 175     


Leu Val Ser Thr Asn Gly Ser Ser Gly Cys Gly Arg Cys His Lys Ser 
            180                 185                 190         


Cys Thr Gly Arg Cys Trp Gly Pro Thr Glu Asn His Cys Gln Thr Leu 
        195                 200                 205             


Thr Arg Thr Val Cys Ala Glu Gln Cys Asp Gly Arg Cys Tyr Gly Pro 
    210                 215                 220                 


Tyr Val Ser Asp Cys Cys His Arg Glu Cys Ala Gly Gly Cys Ser Gly 
225                 230                 235                 240 


Pro Lys Asp Thr Asp Cys Phe Ala Cys Met Asn Phe Asn Asp Ser Gly 
                245                 250                 255     


Ala Cys Val Thr Gln Cys Pro Gln Thr Phe Val Tyr Asn Pro Thr Thr 
            260                 265                 270         


Phe Gln Leu Glu His Asn Phe Asn Ala Lys Tyr Thr Tyr Gly Ala Phe 
        275                 280                 285             


Cys Val Lys Lys Cys Pro His Asn Phe Val Val Asp Ser Ser Ser Cys 
    290                 295                 300                 


Val Arg Ala Cys Pro Ser Ser Lys Met Glu Val Glu Glu Asn Gly Ile 
305                 310                 315                 320 


Lys Met Cys Lys Pro Cys Thr Asp Ile Cys Pro Lys Ala Cys Asp Gly 
                325                 330                 335     


Ile Gly Thr Gly Ser Leu Met Ser Ala Gln Thr Val Asp Ser Ser Asn 
            340                 345                 350         


Ile Asp Lys Phe Ile Asn Cys Thr Lys Ile Asn Gly Asn Leu Ile Phe 
        355                 360                 365             


Leu Val Thr Gly Ile His Gly Asp Pro Tyr Asn Ala Ile Glu Ala Ile 
    370                 375                 380                 


Asp Pro Glu Lys Leu Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly 
385                 390                 395                 400 


Phe Leu Asn Ile Gln Ser Trp Pro Pro Asn Met Thr Asp Phe Ser Val 
                405                 410                 415     


Phe Ser Asn Leu Val Thr Ile Gly Gly Arg Val Leu Tyr Ser Gly Leu 
            420                 425                 430         


Ser Leu Leu Ile Leu Lys Gln Gln Gly Ile Thr Ser Leu Gln Phe Gln 
        435                 440                 445             


Ser Leu Lys Glu Ile Ser Ala Gly Asn Ile Tyr Ile Thr Asp Asn Ser 
    450                 455                 460                 


Asn Leu Cys Tyr Tyr His Thr Ile Asn Trp Thr Thr Leu Phe Ser Thr 
465                 470                 475                 480 


Ile Asn Gln Arg Ile Val Ile Arg Asp Asn Arg Lys Ala Glu Asn Cys 
                485                 490                 495     


Thr Ala Glu Gly Met Val Cys Asn His Leu Cys Ser Ser Asp Gly Cys 
            500                 505                 510         


Trp Gly Pro Gly Pro Asp Gln Cys Leu Ser Cys Arg Arg Phe Ser Arg 
        515                 520                 525             


Gly Arg Ile Cys Ile Glu Ser Cys Asn Leu Tyr Asp Gly Glu Phe Arg 
    530                 535                 540                 


Glu Phe Glu Asn Gly Ser Ile Cys Val Glu Cys Asp Pro Gln Cys Glu 
545                 550                 555                 560 


Lys Met Glu Asp Gly Leu Leu Thr Cys His Gly Pro Gly Pro Asp Asn 
                565                 570                 575     


Cys Thr Lys Cys Ser His Phe Lys Asp Gly Pro Asn Cys Val Glu Lys 
            580                 585                 590         


Cys Pro Asp Gly Leu Gln Gly Ala Asn Ser Phe Ile Phe Lys Tyr Ala 
        595                 600                 605             


Asp Pro Asp Arg Glu Cys His Pro Cys His Pro Asn Cys Thr Gln Gly 
    610                 615                 620                 


Cys Asn Gly Pro Thr Ser His Asp Cys Ile Tyr Tyr Pro Trp Thr Gly 
625                 630                 635                 640 


His Ser Thr Leu Pro Gln His Ala Arg Thr Pro Leu Ile Ala Ala Gly 
                645                 650                 655     


Val Ile Gly Gly Leu Phe Ile Leu Val Ile Val Gly Leu Thr Phe Ala 
            660                 665                 670         


Val Tyr Val Arg Arg Lys Ser Ile Lys Lys Lys Arg Ala Leu Arg Arg 
        675                 680                 685             


Phe Leu Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Thr Ala 
    690                 695                 700                 


Pro Asn Gln Ala Gln Leu Arg Ile Leu Lys Glu Thr Glu Leu Lys Arg 
705                 710                 715                 720 


Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile 
                725                 730                 735     


Trp Val Pro Glu Gly Glu Thr Val Lys Ile Pro Val Ala Ile Lys Ile 
            740                 745                 750         


Leu Asn Glu Thr Thr Gly Pro Lys Ala Asn Val Glu Phe Met Asp Glu 
        755                 760                 765             


Ala Leu Ile Met Ala Ser Met Asp His Pro His Leu Val Arg Leu Leu 
    770                 775                 780                 


Gly Val Cys Leu Ser Pro Thr Ile Gln Leu Val Thr Gln Leu Met Pro 
785                 790                 795                 800 


His Gly Cys Leu Leu Glu Tyr Val His Glu His Lys Asp Asn Ile Gly 
                805                 810                 815     


Ser Gln Leu Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Met 
            820                 825                 830         


Tyr Leu Glu Glu Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn 
        835                 840                 845             


Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu 
    850                 855                 860                 


Ala Arg Leu Leu Glu Gly Asp Glu Lys Glu Tyr Asn Ala Asp Gly Gly 
865                 870                 875                 880 


Lys Met Pro Ile Lys Trp Met Ala Leu Glu Cys Ile His Tyr Arg Lys 
                885                 890                 895     


Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Ile Trp Glu 
            900                 905                 910         


Leu Met Thr Phe Gly Gly Lys Pro Tyr Asp Gly Ile Pro Thr Arg Glu 
        915                 920                 925             


Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile 
    930                 935                 940                 


Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys Trp Met Ile Asp 
945                 950                 955                 960 


Ala Asp Ser Arg Pro Lys Phe Lys Glu Leu Ala Ala Glu Phe Ser Arg 
                965                 970                 975     


Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Asp Arg 
            980                 985                 990         


Met Lys Leu Pro Ser Pro Asn Asp  Ser Lys Phe Phe Gln  Asn Leu Leu 
        995                 1000                 1005             


Asp Glu  Glu Asp Leu Glu Asp  Met Met Asp Ala Glu  Glu Tyr Leu 
    1010                 1015                 1020             


Val Pro  Gln Ala Phe Asn Ile  Pro Pro Pro Ile Tyr  Thr Ser Arg 
    1025                 1030                 1035             


Ala Arg  Ile Asp Ser Asn Arg  Ser Glu Ile Gly His  Ser Pro Pro 
    1040                 1045                 1050             


Pro Ala  Tyr Thr Pro Met Ser  Gly Asn Gln Phe Val  Tyr Arg Asp 
    1055                 1060                 1065             


Gly Gly  Phe Ala Ala Glu Gln  Gly Val Ser Val Pro  Tyr Arg Ala 
    1070                 1075                 1080             


Pro Thr  Ser Thr Ile Pro Glu  Ala Pro Val Ala Gln  Gly Ala Thr 
    1085                 1090                 1095             


Ala Glu  Ile Phe Asp Asp Ser  Cys Cys Asn Gly Thr  Leu Arg Lys 
    1100                 1105                 1110             


Pro Val  Ala Pro His Val Gln  Glu Asp Ser Ser Thr  Gln Arg Tyr 
    1115                 1120                 1125             


Ser Ala  Asp Pro Thr Val Phe  Ala Pro Glu Arg Ser  Pro Arg Gly 
    1130                 1135                 1140             


Glu Leu  Asp Glu Glu Gly Tyr  Met Thr Pro Met Arg  Asp Lys Pro 
    1145                 1150                 1155             


Lys Gln  Glu Tyr Leu Asn Pro  Val Glu Glu Asn Pro  Phe Val Ser 
    1160                 1165                 1170             


Arg Arg  Lys Asn Gly Asp Leu  Gln Ala Leu Asp Asn  Pro Glu Tyr 
    1175                 1180                 1185             


His Asn  Ala Ser Asn Gly Pro  Pro Lys Ala Glu Asp  Glu Tyr Val 
    1190                 1195                 1200             


Asn Glu  Pro Leu Tyr Leu Asn  Thr Phe Ala Asn Thr  Leu Gly Lys 
    1205                 1210                 1215             


Ala Glu  Tyr Leu Lys Asn Asn  Ile Leu Ser Met Pro  Glu Lys Ala 
    1220                 1225                 1230             


Lys Lys  Ala Phe Asp Asn Pro  Asp Tyr Trp Asn His  Ser Leu Pro 
    1235                 1240                 1245             


Pro Arg  Ser Thr Leu Gln His  Pro Asp Tyr Leu Gln  Glu Tyr Ser 
    1250                 1255                 1260             


Thr Lys  Tyr Phe Tyr Lys Gln  Asn Gly Arg Ile Arg  Pro Ile Val 
    1265                 1270                 1275             


Ala Glu  Asn Pro Glu Tyr Leu  Ser Glu Phe Ser Leu  Lys Pro Gly 
    1280                 1285                 1290             


Thr Val  Leu Pro Pro Pro Pro  Tyr Arg His Arg Asn  Thr Val Val 
    1295                 1300                 1305             


<210>  432
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  432

Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Leu Pro Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Lys Arg Arg 
            820         


<210>  433
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210>  434
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  434

Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210>  435
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  436
<211>  1503
<212>  PRT
<213>  Homo sapiens

<400>  436

Met Pro Gly Pro Pro Ala Leu Arg Arg Arg Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Val Leu Leu Ile Ala Gly Ser Ala Gly Ala Ala Pro Leu Pro Gln Thr 
            20                  25                  30          


Gly Ala Gly Glu Ala Pro Pro Ala Ala Glu Val Ser Ser Ser Phe Val 
        35                  40                  45              


Ile Leu Cys Val Cys Ser Leu Ile Ile Leu Ile Val Leu Ile Ala Asn 
    50                  55                  60                  


Cys Val Ser Cys Cys Lys Asp Pro Glu Ile Asp Phe Lys Glu Phe Glu 
65                  70                  75                  80  


Asp Asn Phe Asp Asp Glu Ile Asp Phe Thr Pro Pro Ala Glu Asp Thr 
                85                  90                  95      


Pro Ser Val Gln Ser Pro Ala Glu Val Phe Thr Leu Ser Val Pro Asn 
            100                 105                 110         


Ile Ser Leu Pro Ala Pro Ser Gln Phe Gln Pro Ser Val Glu Gly Leu 
        115                 120                 125             


Lys Ser Gln Val Ala Arg His Ser Leu Asn Tyr Ile Gln Glu Ile Gly 
    130                 135                 140                 


Asn Gly Trp Phe Gly Lys Val Leu Leu Gly Glu Ile Tyr Thr Gly Thr 
145                 150                 155                 160 


Ser Val Ala Arg Val Ile Val Lys Glu Leu Lys Ala Ser Ala Asn Pro 
                165                 170                 175     


Lys Glu Gln Asp Thr Phe Leu Lys Asn Gly Glu Pro Tyr Tyr Ile Leu 
            180                 185                 190         


Gln His Pro Asn Ile Leu Gln Cys Val Gly Gln Cys Val Glu Ala Ile 
        195                 200                 205             


Pro Tyr Leu Leu Val Phe Glu Phe Cys Asp Leu Gly Asp Leu Lys Ala 
    210                 215                 220                 


Tyr Leu Arg Ser Glu Gln Glu His Met Arg Gly Asp Ser Gln Thr Met 
225                 230                 235                 240 


Leu Leu Gln Arg Met Ala Cys Glu Val Ala Ala Gly Leu Ala Ala Met 
                245                 250                 255     


His Lys Leu His Phe Leu His Ser Asp Leu Ala Leu Arg Asn Cys Phe 
            260                 265                 270         


Leu Thr Ser Asp Leu Asn Val Lys Val Gly Asp Tyr Gly Ile Gly Phe 
        275                 280                 285             


Ser Arg Tyr Lys Glu Asp Tyr Ile Glu Thr Asp Asp Lys Lys Val Phe 
    290                 295                 300                 


Pro Leu Arg Trp Thr Ala Pro Glu Leu Val Thr Ser Phe Gln Asp Arg 
305                 310                 315                 320 


Leu Leu Thr Ala Asp Gln Thr Lys Tyr Ser Asn Ile Trp Ser Leu Gly 
                325                 330                 335     


Val Thr Leu Trp Glu Leu Phe Asp Asn Ala Ala Gln Pro Tyr Ser Asn 
            340                 345                 350         


Leu Ser Asn Leu Asp Val Leu Asn Gln Val Ile Arg Glu Arg Asp Thr 
        355                 360                 365             


Lys Leu Pro Lys Pro Gln Leu Glu Gln Pro Tyr Ser Asp Arg Trp Tyr 
    370                 375                 380                 


Glu Val Leu Gln Phe Cys Trp Leu Ser Pro Glu Lys Arg Pro Ala Ala 
385                 390                 395                 400 


Glu Asp Val His Arg Leu Leu Thr Tyr Leu Arg Leu Gln Ser Gln Arg 
                405                 410                 415     


Asp Ser Glu Val Asp Phe Glu Gln Gln Trp Asn Ala Leu Lys Pro Asn 
            420                 425                 430         


Thr Asn Ser Arg Asp Ser Ser Asn Asn Ala Ala Phe Pro Ile Leu Asp 
        435                 440                 445             


His Phe Ala Arg Asp Arg Leu Gly Arg Glu Met Glu Glu Val Leu Thr 
    450                 455                 460                 


Val Thr Glu Thr Ser Gln Gly Leu Ser Phe Glu Tyr Val Trp Glu Ala 
465                 470                 475                 480 


Ala Lys His Asp His Phe Asp Glu Arg Ser Arg Gly His Leu Asp Glu 
                485                 490                 495     


Gly Leu Ser Tyr Thr Ser Ile Phe Tyr Pro Val Glu Val Phe Glu Ser 
            500                 505                 510         


Ser Leu Ser Asp Pro Gly Pro Gly Lys Gln Asp Asp Ser Gly Gln Asp 
        515                 520                 525             


Val Pro Leu Arg Val Pro Gly Val Val Pro Val Phe Asp Ala His Asn 
    530                 535                 540                 


Leu Ser Val Gly Ser Asp Tyr Tyr Ile Gln Leu Glu Glu Lys Ser Gly 
545                 550                 555                 560 


Ser Asn Leu Glu Leu Asp Tyr Pro Pro Ala Leu Leu Thr Thr Asp Met 
                565                 570                 575     


Asp Asn Pro Glu Arg Thr Gly Pro Glu Leu Ser Gln Leu Thr Ala Leu 
            580                 585                 590         


Arg Ser Val Glu Leu Glu Glu Ser Ser Thr Asp Glu Asp Phe Phe Gln 
        595                 600                 605             


Ser Ser Thr Asp Pro Lys Asp Ser Ser Leu Pro Gly Asp Leu His Val 
    610                 615                 620                 


Thr Ser Gly Pro Glu Ser Pro Phe Asn Asn Ile Phe Asn Asp Val Asp 
625                 630                 635                 640 


Lys Ser Glu Asp Leu Pro Ser His Gln Lys Ile Phe Asp Leu Met Glu 
                645                 650                 655     


Leu Asn Gly Val Gln Ala Asp Phe Lys Pro Ala Thr Leu Ser Ser Ser 
            660                 665                 670         


Leu Asp Asn Pro Lys Glu Ser Val Ile Thr Gly His Phe Glu Lys Glu 
        675                 680                 685             


Lys Pro Arg Lys Ile Phe Asp Ser Glu Pro Leu Cys Leu Ser Asp Asn 
    690                 695                 700                 


Leu Met His Gln Asp Asn Phe Asp Pro Leu Asn Val Gln Glu Leu Ser 
705                 710                 715                 720 


Glu Asn Phe Leu Phe Leu Gln Glu Lys Asn Leu Leu Lys Gly Ser Leu 
                725                 730                 735     


Ser Ser Lys Glu His Ile Asn Asp Leu Gln Thr Glu Leu Lys Asn Ala 
            740                 745                 750         


Gly Phe Thr Glu Ala Met Leu Glu Thr Ser Cys Arg Asn Ser Leu Asp 
        755                 760                 765             


Thr Glu Leu Gln Phe Ala Glu Asn Lys Pro Gly Leu Ser Leu Leu Gln 
    770                 775                 780                 


Glu Asn Val Ser Thr Lys Gly Asp Asp Thr Asp Val Met Leu Thr Gly 
785                 790                 795                 800 


Asp Thr Leu Ser Thr Ser Leu Gln Ser Ser Pro Glu Val Gln Val Pro 
                805                 810                 815     


Pro Thr Ser Phe Glu Thr Glu Glu Thr Pro Arg Arg Val Pro Pro Asp 
            820                 825                 830         


Ser Leu Pro Thr Gln Gly Glu Thr Gln Pro Thr Cys Leu Asp Val Ile 
        835                 840                 845             


Val Pro Glu Asp Cys Leu His Gln Asp Ile Ser Pro Asp Ala Val Thr 
    850                 855                 860                 


Val Pro Val Glu Ile Leu Ser Thr Asp Ala Arg Thr His Ser Leu Asp 
865                 870                 875                 880 


Asn Arg Ser Gln Asp Ser Pro Gly Glu Ser Glu Glu Thr Leu Arg Leu 
                885                 890                 895     


Thr Glu Ser Asp Ser Val Leu Ala Asp Asp Ile Leu Ala Ser Arg Val 
            900                 905                 910         


Ser Val Gly Ser Ser Leu Pro Glu Leu Gly Gln Glu Leu His Asn Lys 
        915                 920                 925             


Pro Phe Ser Glu Asp His His Ser His Arg Arg Leu Glu Lys Asn Leu 
    930                 935                 940                 


Glu Ala Val Glu Thr Leu Asn Gln Leu Asn Ser Lys Asp Ala Ala Lys 
945                 950                 955                 960 


Glu Ala Gly Leu Val Ser Ala Leu Ser Ser Asp Ser Thr Ser Gln Asp 
                965                 970                 975     


Ser Leu Leu Glu Asp Ser Leu Ser Ala Pro Phe Pro Ala Ser Glu Pro 
            980                 985                 990         


Ser Leu Glu Thr Pro Asp Ser Leu  Glu Ser Val Asp Val  His Glu Ala 
        995                 1000                 1005             


Leu Leu  Asp Ser Leu Gly Ser  His Thr Pro Gln Lys  Leu Val Pro 
    1010                 1015                 1020             


Pro Asp  Lys Pro Ala Asp Ser  Gly Tyr Glu Thr Glu  Asn Leu Glu 
    1025                 1030                 1035             


Ser Pro  Glu Trp Thr Leu His  Pro Ala Pro Glu Gly  Thr Ala Asp 
    1040                 1045                 1050             


Ser Glu  Pro Ala Thr Thr Gly  Asp Gly Gly His Ser  Gly Leu Pro 
    1055                 1060                 1065             


Pro Asn  Pro Val Ile Val Ile  Ser Asp Ala Gly Asp  Gly His Arg 
    1070                 1075                 1080             


Gly Thr  Glu Val Thr Pro Glu  Thr Phe Thr Ala Gly  Ser Gln Gly 
    1085                 1090                 1095             


Ser Tyr  Arg Asp Ser Ala Tyr  Phe Ser Asp Asn Asp  Ser Glu Pro 
    1100                 1105                 1110             


Glu Lys  Arg Ser Glu Glu Val  Pro Gly Thr Ser Pro  Ser Ala Leu 
    1115                 1120                 1125             


Val Leu  Val Gln Glu Gln Pro  Leu Pro Glu Pro Val  Leu Pro Glu 
    1130                 1135                 1140             


Gln Ser  Pro Ala Ala Gln Asp  Ser Cys Leu Glu Ala  Arg Lys Ser 
    1145                 1150                 1155             


Gln Pro  Asp Glu Ser Cys Leu  Ser Ala Leu His Asn  Ser Ser Asp 
    1160                 1165                 1170             


Leu Glu  Leu Arg Ala Thr Pro  Glu Pro Ala Gln Thr  Gly Val Pro 
    1175                 1180                 1185             


Gln Gln  Val His Pro Thr Glu  Asp Glu Ala Ser Ser  Pro Trp Ser 
    1190                 1195                 1200             


Val Leu  Asn Ala Glu Leu Ser  Ser Gly Asp Asp Phe  Glu Thr Gln 
    1205                 1210                 1215             


Asp Asp  Arg Pro Cys Thr Leu  Ala Ser Thr Gly Thr  Asn Thr Asn 
    1220                 1225                 1230             


Glu Leu  Leu Ala Tyr Thr Asn  Ser Ala Leu Asp Lys  Ser Leu Ser 
    1235                 1240                 1245             


Ser His  Ser Glu Gly Pro Lys  Leu Lys Glu Pro Asp  Ile Glu Gly 
    1250                 1255                 1260             


Lys Tyr  Leu Gly Lys Leu Gly  Val Ser Gly Met Leu  Asp Leu Ser 
    1265                 1270                 1275             


Glu Asp  Gly Met Asp Ala Asp  Glu Glu Asp Glu Asn  Ser Asp Asp 
    1280                 1285                 1290             


Ser Asp  Glu Asp Leu Arg Ala  Phe Asn Leu His Ser  Leu Ser Ser 
    1295                 1300                 1305             


Glu Ser  Glu Asp Glu Thr Glu  His Pro Val Pro Ile  Ile Leu Ser 
    1310                 1315                 1320             


Asn Glu  Asp Gly Arg His Leu  Arg Ser Leu Leu Lys  Pro Thr Ala 
    1325                 1330                 1335             


Ala Asn  Ala Pro Asp Pro Leu  Pro Glu Asp Trp Lys  Lys Glu Lys 
    1340                 1345                 1350             


Lys Ala  Val Thr Phe Phe Asp  Asp Val Thr Val Tyr  Leu Phe Asp 
    1355                 1360                 1365             


Gln Glu  Thr Pro Thr Lys Glu  Leu Gly Pro Cys Gly  Gly Glu Ala 
    1370                 1375                 1380             


Cys Gly  Pro Asp Leu Ser Gly  Pro Ala Pro Ala Ser  Gly Ser Pro 
    1385                 1390                 1395             


Tyr Leu  Ser Arg Cys Ile Asn  Ser Glu Ser Ser Thr  Asp Glu Glu 
    1400                 1405                 1410             


Gly Gly  Gly Phe Glu Trp Asp  Asp Asp Phe Ser Pro  Asp Pro Phe 
    1415                 1420                 1425             


Met Ser  Lys Thr Thr Ser Asn  Leu Leu Ser Ser Lys  Pro Ser Leu 
    1430                 1435                 1440             


Gln Thr  Ser Lys Tyr Phe Ser  Pro Pro Pro Pro Ala  Arg Ser Thr 
    1445                 1450                 1455             


Glu Gln  Ser Trp Pro His Ser  Ala Pro Tyr Ser Arg  Phe Ser Ile 
    1460                 1465                 1470             


Ser Pro  Ala Asn Ile Ala Ser  Phe Ser Leu Thr His  Leu Thr Asp 
    1475                 1480                 1485             


Ser Asp  Ile Glu Gln Gly Gly  Ser Ser Glu Asp Gly  Glu Lys Asp 
    1490                 1495                 1500             


<210>  437
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  437

Met Val Ser Tyr Trp Asp Thr Gly Val Leu Leu Cys Ala Leu Leu Ser 
1               5                   10                  15      


Cys Leu Leu Leu Thr Gly Ser Ser Ser Gly Ser Lys Leu Lys Asp Pro 
            20                  25                  30          


Glu Leu Ser Leu Lys Gly Thr Gln His Ile Met Gln Ala Gly Gln Thr 
        35                  40                  45              


Leu His Leu Gln Cys Arg Gly Glu Ala Ala His Lys Trp Ser Leu Pro 
    50                  55                  60                  


Glu Met Val Ser Lys Glu Ser Glu Arg Leu Ser Ile Thr Lys Ser Ala 
65                  70                  75                  80  


Cys Gly Arg Asn Gly Lys Gln Phe Cys Ser Thr Leu Thr Leu Asn Thr 
                85                  90                  95      


Ala Gln Ala Asn His Thr Gly Phe Tyr Ser Cys Lys Tyr Leu Ala Val 
            100                 105                 110         


Pro Thr Ser Lys Lys Lys Glu Thr Glu Ser Ala Ile Tyr Ile Phe Ile 
        115                 120                 125             


Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
    130                 135                 140                 


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
145                 150                 155                 160 


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
                165                 170                 175     


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
            180                 185                 190         


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
        195                 200                 205             


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
    210                 215                 220                 


Gln Thr Asn Thr Ile Ile Asp Val Gln Ile Ser Thr Pro Arg Pro Val 
225                 230                 235                 240 


Lys Leu Leu Arg Gly His Thr Leu Val Leu Asn Cys Thr Ala Thr Thr 
                245                 250                 255     


Pro Leu Asn Thr Arg Val Gln Met Thr Trp Ser Tyr Pro Asp Glu Lys 
            260                 265                 270         


Asn Lys Arg Ala Ser Val Arg Arg Arg Ile Asp Gln Ser Asn Ser His 
        275                 280                 285             


Ala Asn Ile Phe Tyr Ser Val Leu Thr Ile Asp Lys Met Gln Asn Lys 
    290                 295                 300                 


Asp Lys Gly Leu Tyr Thr Cys Arg Val Arg Ser Gly Pro Ser Phe Lys 
305                 310                 315                 320 


Ser Val Asn Thr Ser Val His Ile Tyr Asp Lys Ala Phe Ile Thr Val 
                325                 330                 335     


Lys His Arg Lys Gln Gln Val Leu Glu Thr Val Ala Gly Lys Arg Ser 
            340                 345                 350         


Tyr Arg Leu Ser Met Lys Val Lys Ala Phe Pro Ser Pro Glu Val Val 
        355                 360                 365             


Trp Leu Lys Asp Gly Leu Pro Ala Thr Glu Lys Ser Ala Arg Tyr Leu 
    370                 375                 380                 


Thr Arg Gly Tyr Ser Leu Ile Ile Lys Asp Val Thr Glu Glu Asp Ala 
385                 390                 395                 400 


Gly Asn Tyr Thr Ile Leu Leu Ser Ile Lys Gln Ser Asn Val Phe Lys 
                405                 410                 415     


Asn Leu Thr Ala Thr Leu Ile Val Asn Val Lys Pro Gln Ile Tyr Glu 
            420                 425                 430         


Lys Ala Val Ser Ser Phe Pro Asp Pro Ala Leu Tyr Pro Leu Gly Ser 
        435                 440                 445             


Arg Gln Ile Leu Thr Cys Thr Ala Tyr Gly Ile Pro Gln Pro Thr Ile 
    450                 455                 460                 


Lys Trp Phe Trp His Pro Cys Asn His Asn His Ser Glu Ala Arg Cys 
465                 470                 475                 480 


Asp Phe Cys Ser Asn Asn Glu Glu Ser Phe Ile Leu Asp Ala Asp Ser 
                485                 490                 495     


Asn Met Gly Asn Arg Ile Glu Ser Ile Thr Gln Arg Met Ala Ile Ile 
            500                 505                 510         


Glu Gly Lys Asn Lys Met Ala Ser Thr Leu Val Val Ala Asp Ser Arg 
        515                 520                 525             


Ile Ser Gly Ile Tyr Ile Cys Ile Ala Ser Asn Lys Val Gly Thr Val 
    530                 535                 540                 


Gly Arg Asn Ile Ser Phe Tyr Ile Thr Asp Val Pro Asn Gly Phe His 
545                 550                 555                 560 


Val Asn Leu Glu Lys Met Pro Thr Glu Gly Glu Asp Leu Lys Leu Ser 
                565                 570                 575     


Cys Thr Val Asn Lys Phe Leu Tyr Arg Asp Val Thr Trp Ile Leu Leu 
            580                 585                 590         


Arg Thr Val Asn Asn Arg Thr Met His Tyr Ser Ile Ser Lys Gln Lys 
        595                 600                 605             


Met Ala Ile Thr Lys Glu His Ser Ile Thr Leu Asn Leu Thr Ile Met 
    610                 615                 620                 


Asn Val Ser Leu Gln Asp Ser Gly Thr Tyr Ala Cys Arg Ala Arg Asn 
625                 630                 635                 640 


Val Tyr Thr Gly Glu Glu Ile Leu Gln Lys Lys Glu Ile Thr Ile Arg 
                645                 650                 655     


Asp Gln Glu Ala Pro Tyr Leu Leu Arg Asn Leu Ser Asp His Thr Val 
            660                 665                 670         


Ala Ile Ser Ser Ser Thr Thr Leu Asp Cys His Ala Asn Gly Val Pro 
        675                 680                 685             


Glu Pro Gln Ile Thr Trp Phe Lys Asn Asn His Lys Ile Gln Gln Glu 
    690                 695                 700                 


Pro Gly Ile Ile Leu Gly Pro Gly Ser Ser Thr Leu Phe Ile Glu Arg 
705                 710                 715                 720 


Val Thr Glu Glu Asp Glu Gly Val Tyr His Cys Lys Ala Thr Asn Gln 
                725                 730                 735     


Lys Gly Ser Val Glu Ser Ser Ala Tyr Leu Thr Val Gln Gly Thr Ser 
            740                 745                 750         


Asp Lys Ser Asn Leu Glu Leu Ile Thr Leu Thr Cys Thr Cys Val Ala 
        755                 760                 765             


Ala Thr Leu Phe Trp Leu Leu Leu Thr Leu Phe Ile Arg Lys Met Lys 
    770                 775                 780                 


Arg Ser Ser Ser Glu Ile Lys Thr Asp Tyr Leu Ser Ile Ile Met Asp 
785                 790                 795                 800 


Pro Asp Glu Val Pro Leu Asp Glu Gln Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Ala Arg Glu Arg Leu Lys Leu Gly Lys Ser 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Lys Val Val Gln Ala Ser Ala Phe Gly 
        835                 840                 845             


Ile Lys Lys Ser Pro Thr Cys Arg Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr Ala Ser Glu Tyr Lys Ala Leu Met Thr Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Thr His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Gln Gly Gly Pro Leu Met Val Ile Val Glu Tyr Cys 
            900                 905                 910         


Lys Tyr Gly Asn Leu Ser Asn Tyr Leu Lys Ser Lys Arg Asp Leu Phe 
        915                 920                 925             


Phe Leu Asn Lys Asp Ala Ala Leu His Met Glu Pro Lys Lys Glu Lys 
    930                 935                 940                 


Met Glu Pro Gly Leu Glu Gln Gly Lys Lys Pro Arg Leu Asp Ser Val 
945                 950                 955                 960 


Thr Ser Ser Glu Ser Phe Ala Ser Ser Gly Phe Gln Glu Asp Lys Ser 
                965                 970                 975     


Leu Ser Asp Val Glu Glu Glu Glu Asp Ser Asp Gly Phe Tyr Lys Glu 
            980                 985                 990         


Pro Ile Thr Met Glu Asp Leu Ile  Ser Tyr Ser Phe Gln  Val Ala Arg 
        995                 1000                 1005             


Gly Met  Glu Phe Leu Ser Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1010                 1015                 1020             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Asn Asn Val  Val Lys Ile 
    1025                 1030                 1035             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asn  Pro Asp Tyr 
    1040                 1045                 1050             


Val Arg  Lys Gly Asp Thr Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1055                 1060                 1065             


Glu Ser  Ile Phe Asp Lys Ile  Tyr Ser Thr Lys Ser  Asp Val Trp 
    1070                 1075                 1080             


Ser Tyr  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Gly Ser 
    1085                 1090                 1095             


Pro Tyr  Pro Gly Val Gln Met  Asp Glu Asp Phe Cys  Ser Arg Leu 
    1100                 1105                 1110             


Arg Glu  Gly Met Arg Met Arg  Ala Pro Glu Tyr Ser  Thr Pro Glu 
    1115                 1120                 1125             


Ile Tyr  Gln Ile Met Leu Asp  Cys Trp His Arg Asp  Pro Lys Glu 
    1130                 1135                 1140             


Arg Pro  Arg Phe Ala Glu Leu  Val Glu Lys Leu Gly  Asp Leu Leu 
    1145                 1150                 1155             


Gln Ala  Asn Val Gln Gln Asp  Gly Lys Asp Tyr Ile  Pro Ile Asn 
    1160                 1165                 1170             


Ala Ile  Leu Thr Gly Asn Ser  Gly Phe Thr Tyr Ser  Thr Pro Ala 
    1175                 1180                 1185             


Phe Ser  Glu Asp Phe Phe Lys  Glu Ser Ile Ser Ala  Pro Lys Phe 
    1190                 1195                 1200             


Asn Ser  Gly Ser Ser Asp Asp  Val Arg Tyr Val Asn  Ala Phe Lys 
    1205                 1210                 1215             


Phe Met  Ser Leu Glu Arg Ile  Lys Thr Phe Glu Glu  Leu Leu Pro 
    1220                 1225                 1230             


Asn Ala  Thr Ser Met Phe Asp  Asp Tyr Gln Gly Asp  Ser Ser Thr 
    1235                 1240                 1245             


Leu Leu  Ala Ser Pro Met Leu  Lys Arg Phe Thr Trp  Thr Asp Ser 
    1250                 1255                 1260             


Lys Pro  Lys Ala Ser Leu Lys  Ile Asp Leu Arg Val  Thr Ser Lys 
    1265                 1270                 1275             


Ser Lys  Glu Ser Gly Leu Ser  Asp Val Ser Arg Pro  Ser Phe Cys 
    1280                 1285                 1290             


His Ser  Ser Cys Gly His Val  Ser Glu Gly Lys Arg  Arg Phe Thr 
    1295                 1300                 1305             


Tyr Asp  His Ala Glu Leu Glu  Arg Lys Ile Ala Cys  Cys Ser Pro 
    1310                 1315                 1320             


Pro Pro  Asp Tyr Asn Ser Val  Val Leu Tyr Ser Thr  Pro Pro Ile 
    1325                 1330                 1335             


<210>  438
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  438

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


<210>  439
<211>  1363
<212>  PRT
<213>  Homo sapiens

<400>  439

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Ser Cys Lys  Gly Pro Gly Gln Asn  Val Ala Val 
    1295                 1300                 1305             


Thr Arg  Ala His Pro Asp Ser  Gln Gly Arg Arg Arg  Arg Pro Glu 
    1310                 1315                 1320             


Arg Gly  Ala Arg Gly Gly Gln  Val Phe Tyr Asn Ser  Glu Tyr Gly 
    1325                 1330                 1335             


Glu Leu  Ser Glu Pro Ser Glu  Glu Asp His Cys Ser  Pro Ser Ala 
    1340                 1345                 1350             


Arg Val  Thr Phe Phe Thr Asp  Asn Ser Tyr 
    1355                 1360             


<210>  440
<211>  1620
<212>  PRT
<213>  Homo sapiens

<400>  440

Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Val Tyr Arg  Arg Lys His Gln Glu  Leu Gln Ala 
    1055                 1060                 1065             


Met Gln  Met Glu Leu Gln Ser  Pro Glu Tyr Lys Leu  Ser Lys Leu 
    1070                 1075                 1080             


Arg Thr  Ser Thr Ile Met Thr  Asp Tyr Asn Pro Asn  Tyr Cys Phe 
    1085                 1090                 1095             


Ala Gly  Lys Thr Ser Ser Ile  Ser Asp Leu Lys Glu  Val Pro Arg 
    1100                 1105                 1110             


Lys Asn  Ile Thr Leu Ile Arg  Gly Leu Gly His Gly  Ala Phe Gly 
    1115                 1120                 1125             


Glu Val  Tyr Glu Gly Gln Val  Ser Gly Met Pro Asn  Asp Pro Ser 
    1130                 1135                 1140             


Pro Leu  Gln Val Ala Val Lys  Thr Leu Pro Glu Val  Cys Ser Glu 
    1145                 1150                 1155             


Gln Asp  Glu Leu Asp Phe Leu  Met Glu Ala Leu Ile  Ile Ser Lys 
    1160                 1165                 1170             


Phe Asn  His Gln Asn Ile Val  Arg Cys Ile Gly Val  Ser Leu Gln 
    1175                 1180                 1185             


Ser Leu  Pro Arg Phe Ile Leu  Leu Glu Leu Met Ala  Gly Gly Asp 
    1190                 1195                 1200             


Leu Lys  Ser Phe Leu Arg Glu  Thr Arg Pro Arg Pro  Ser Gln Pro 
    1205                 1210                 1215             


Ser Ser  Leu Ala Met Leu Asp  Leu Leu His Val Ala  Arg Asp Ile 
    1220                 1225                 1230             


Ala Cys  Gly Cys Gln Tyr Leu  Glu Glu Asn His Phe  Ile His Arg 
    1235                 1240                 1245             


Asp Ile  Ala Ala Arg Asn Cys  Leu Leu Thr Cys Pro  Gly Pro Gly 
    1250                 1255                 1260             


Arg Val  Ala Lys Ile Gly Asp  Phe Gly Met Ala Arg  Asp Ile Tyr 
    1265                 1270                 1275             


Arg Ala  Ser Tyr Tyr Arg Lys  Gly Gly Cys Ala Met  Leu Pro Val 
    1280                 1285                 1290             


Lys Trp  Met Pro Pro Glu Ala  Phe Met Glu Gly Ile  Phe Thr Ser 
    1295                 1300                 1305             


Lys Thr  Asp Thr Trp Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe 
    1310                 1315                 1320             


Ser Leu  Gly Tyr Met Pro Tyr  Pro Ser Lys Ser Asn  Gln Glu Val 
    1325                 1330                 1335             


Leu Glu  Phe Val Thr Ser Gly  Gly Arg Met Asp Pro  Pro Lys Asn 
    1340                 1345                 1350             


Cys Pro  Gly Pro Val Tyr Arg  Ile Met Thr Gln Cys  Trp Gln His 
    1355                 1360                 1365             


Gln Pro  Glu Asp Arg Pro Asn  Phe Ala Ile Ile Leu  Glu Arg Ile 
    1370                 1375                 1380             


Glu Tyr  Cys Thr Gln Asp Pro  Asp Val Ile Asn Thr  Ala Leu Pro 
    1385                 1390                 1395             


Ile Glu  Tyr Gly Pro Leu Val  Glu Glu Glu Glu Lys  Val Pro Val 
    1400                 1405                 1410             


Arg Pro  Lys Asp Pro Glu Gly  Val Pro Pro Leu Leu  Val Ser Gln 
    1415                 1420                 1425             


Gln Ala  Lys Arg Glu Glu Glu  Arg Ser Pro Ala Ala  Pro Pro Pro 
    1430                 1435                 1440             


Leu Pro  Thr Thr Ser Ser Gly  Lys Ala Ala Lys Lys  Pro Thr Ala 
    1445                 1450                 1455             


Ala Glu  Ile Ser Val Arg Val  Pro Arg Gly Pro Ala  Val Glu Gly 
    1460                 1465                 1470             


Gly His  Val Asn Met Ala Phe  Ser Gln Ser Asn Pro  Pro Ser Glu 
    1475                 1480                 1485             


Leu His  Lys Val His Gly Ser  Arg Asn Lys Pro Thr  Ser Leu Trp 
    1490                 1495                 1500             


Asn Pro  Thr Tyr Gly Ser Trp  Phe Thr Glu Lys Pro  Thr Lys Lys 
    1505                 1510                 1515             


Asn Asn  Pro Ile Ala Lys Lys  Glu Pro His Asp Arg  Gly Asn Leu 
    1520                 1525                 1530             


Gly Leu  Glu Gly Ser Cys Thr  Val Pro Pro Asn Val  Ala Thr Gly 
    1535                 1540                 1545             


Arg Leu  Pro Gly Ala Ser Leu  Leu Leu Glu Pro Ser  Ser Leu Thr 
    1550                 1555                 1560             


Ala Asn  Met Lys Glu Val Pro  Leu Phe Arg Leu Arg  His Phe Pro 
    1565                 1570                 1575             


Cys Gly  Asn Val Asn Tyr Gly  Tyr Gln Gln Gln Gly  Leu Pro Leu 
    1580                 1585                 1590             


Glu Ala  Ala Thr Ala Pro Gly  Ala Gly His Tyr Glu  Asp Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Lys Asn Ser Met  Asn Gln Pro Gly Pro  
    1610                 1615                 1620 


<210>  441
<211>  1008
<212>  PRT
<213>  Homo sapiens

<400>  441

Met Glu Thr Cys Ala Gly Pro His Pro Leu Arg Leu Phe Leu Cys Arg 
1               5                   10                  15      


Met Gln Leu Cys Leu Ala Leu Leu Leu Gly Pro Trp Arg Pro Gly Thr 
            20                  25                  30          


Ala Glu Glu Val Ile Leu Leu Asp Ser Lys Ala Ser Gln Ala Glu Leu 
        35                  40                  45              


Gly Trp Thr Ala Leu Pro Ser Asn Gly Trp Glu Glu Ile Ser Gly Val 
    50                  55                  60                  


Asp Glu His Asp Arg Pro Ile Arg Thr Tyr Gln Val Cys Asn Val Leu 
65                  70                  75                  80  


Glu Pro Asn Gln Asp Asn Trp Leu Gln Thr Gly Trp Ile Ser Arg Gly 
                85                  90                  95      


Arg Gly Gln Arg Ile Phe Val Glu Leu Gln Phe Thr Leu Arg Asp Cys 
            100                 105                 110         


Ser Ser Ile Pro Gly Ala Ala Gly Thr Cys Lys Glu Thr Phe Asn Val 
        115                 120                 125             


Tyr Tyr Leu Glu Thr Glu Ala Asp Leu Gly Arg Gly Arg Pro Arg Leu 
    130                 135                 140                 


Gly Gly Ser Arg Pro Arg Lys Ile Asp Thr Ile Ala Ala Asp Glu Ser 
145                 150                 155                 160 


Phe Thr Gln Gly Asp Leu Gly Glu Arg Lys Met Lys Leu Asn Thr Glu 
                165                 170                 175     


Val Arg Glu Ile Gly Pro Leu Ser Arg Arg Gly Phe His Leu Ala Phe 
            180                 185                 190         


Gln Asp Val Gly Ala Cys Val Ala Leu Val Ser Val Arg Val Tyr Tyr 
        195                 200                 205             


Lys Gln Cys Arg Ala Thr Val Arg Gly Leu Ala Thr Phe Pro Ala Thr 
    210                 215                 220                 


Ala Ala Glu Ser Ala Phe Ser Thr Leu Val Glu Val Ala Gly Thr Cys 
225                 230                 235                 240 


Val Ala His Ser Glu Gly Glu Pro Gly Ser Pro Pro Arg Met His Cys 
                245                 250                 255     


Gly Ala Asp Gly Glu Trp Leu Val Pro Val Gly Arg Cys Ser Cys Ser 
            260                 265                 270         


Ala Gly Phe Gln Glu Arg Gly Asp Phe Cys Glu Ala Cys Pro Pro Gly 
        275                 280                 285             


Phe Tyr Lys Val Ser Pro Arg Arg Pro Leu Cys Ser Pro Cys Pro Glu 
    290                 295                 300                 


His Ser Arg Ala Leu Glu Asn Ala Ser Thr Phe Cys Val Cys Gln Asp 
305                 310                 315                 320 


Ser Tyr Ala Arg Ser Pro Thr Asp Pro Pro Ser Ala Ser Cys Thr Arg 
                325                 330                 335     


Pro Pro Ser Ala Pro Arg Asp Leu Gln Tyr Ser Leu Ser Arg Ser Pro 
            340                 345                 350         


Leu Val Leu Arg Leu Arg Trp Leu Pro Pro Ala Asp Ser Gly Gly Arg 
        355                 360                 365             


Ser Asp Val Thr Tyr Ser Leu Leu Cys Leu Arg Cys Gly Arg Glu Gly 
    370                 375                 380                 


Pro Ala Gly Ala Cys Glu Pro Cys Gly Pro Arg Val Ala Phe Leu Pro 
385                 390                 395                 400 


Arg Gln Ala Gly Leu Arg Glu Arg Ala Ala Thr Leu Leu His Leu Arg 
                405                 410                 415     


Pro Gly Ala Arg Tyr Thr Val Arg Val Ala Ala Leu Asn Gly Val Ser 
            420                 425                 430         


Gly Pro Ala Ala Ala Ala Gly Thr Thr Tyr Ala Gln Val Thr Val Ser 
        435                 440                 445             


Thr Gly Pro Gly Ala Pro Trp Glu Glu Asp Glu Ile Arg Arg Asp Arg 
    450                 455                 460                 


Val Glu Pro Gln Ser Val Ser Leu Ser Trp Arg Glu Pro Ile Pro Ala 
465                 470                 475                 480 


Gly Ala Pro Gly Ala Asn Asp Thr Glu Tyr Glu Ile Arg Tyr Tyr Glu 
                485                 490                 495     


Lys Gly Gln Ser Glu Gln Thr Tyr Ser Met Val Lys Thr Gly Ala Pro 
            500                 505                 510         


Thr Val Thr Val Thr Asn Leu Lys Pro Ala Thr Arg Tyr Val Phe Gln 
        515                 520                 525             


Ile Arg Ala Ala Ser Pro Gly Pro Ser Trp Glu Ala Gln Ser Phe Asn 
    530                 535                 540                 


Pro Ser Ile Glu Val Gln Thr Leu Gly Glu Ala Ala Ser Gly Ser Arg 
545                 550                 555                 560 


Asp Gln Ser Pro Ala Ile Val Val Thr Val Val Thr Ile Ser Ala Leu 
                565                 570                 575     


Leu Val Leu Gly Ser Val Met Ser Val Leu Ala Ile Trp Arg Arg Pro 
            580                 585                 590         


Cys Ser Tyr Gly Lys Gly Gly Gly Asp Ala His Asp Glu Glu Glu Leu 
        595                 600                 605             


Tyr Phe His Phe Lys Val Pro Thr Arg Arg Thr Phe Leu Asp Pro Gln 
    610                 615                 620                 


Ser Cys Gly Asp Leu Leu Gln Ala Val His Leu Phe Ala Lys Glu Leu 
625                 630                 635                 640 


Asp Ala Lys Ser Val Thr Leu Glu Arg Ser Leu Gly Gly Gly Arg Phe 
                645                 650                 655     


Gly Glu Leu Cys Cys Gly Cys Leu Gln Leu Pro Gly Arg Gln Glu Leu 
            660                 665                 670         


Leu Val Ala Val His Met Leu Arg Asp Ser Ala Ser Asp Ser Gln Arg 
        675                 680                 685             


Leu Gly Phe Leu Ala Glu Ala Leu Thr Leu Gly Gln Phe Asp His Ser 
    690                 695                 700                 


His Ile Val Arg Leu Glu Gly Val Val Thr Arg Gly Ser Thr Leu Met 
705                 710                 715                 720 


Ile Val Thr Glu Tyr Met Ser His Gly Ala Leu Asp Gly Phe Leu Arg 
                725                 730                 735     


Arg His Glu Gly Gln Leu Val Ala Gly Gln Leu Met Gly Leu Leu Pro 
            740                 745                 750         


Gly Leu Ala Ser Ala Met Lys Tyr Leu Ser Glu Met Gly Tyr Val His 
        755                 760                 765             


Arg Gly Leu Ala Ala Arg His Val Leu Val Ser Ser Asp Leu Val Cys 
    770                 775                 780                 


Lys Ile Ser Gly Phe Gly Arg Gly Pro Arg Asp Arg Ser Glu Ala Val 
785                 790                 795                 800 


Tyr Thr Thr Met Ser Gly Arg Ser Pro Ala Leu Trp Ala Ala Pro Glu 
                805                 810                 815     


Thr Leu Gln Phe Gly His Phe Ser Ser Ala Ser Asp Val Trp Ser Phe 
            820                 825                 830         


Gly Ile Ile Met Trp Glu Val Met Ala Phe Gly Glu Arg Pro Tyr Trp 
        835                 840                 845             


Asp Met Ser Gly Gln Asp Val Ile Lys Ala Val Glu Asp Gly Phe Arg 
    850                 855                 860                 


Leu Pro Pro Pro Arg Asn Cys Pro Asn Leu Leu His Arg Leu Met Leu 
865                 870                 875                 880 


Asp Cys Trp Gln Lys Asp Pro Gly Glu Arg Pro Arg Phe Ser Gln Ile 
                885                 890                 895     


His Ser Ile Leu Ser Lys Met Val Gln Asp Pro Glu Pro Pro Lys Cys 
            900                 905                 910         


Ala Leu Thr Thr Cys Pro Arg Pro Pro Thr Pro Leu Ala Asp Arg Ala 
        915                 920                 925             


Phe Ser Thr Phe Pro Ser Phe Gly Ser Val Gly Ala Trp Leu Glu Ala 
    930                 935                 940                 


Leu Asp Leu Cys Arg Tyr Lys Asp Ser Phe Ala Ala Ala Gly Tyr Gly 
945                 950                 955                 960 


Ser Leu Glu Ala Val Ala Glu Met Thr Ala Gln Asp Leu Val Ser Leu 
                965                 970                 975     


Gly Ile Ser Leu Ala Glu His Arg Glu Ala Leu Leu Ser Gly Ile Ser 
            980                 985                 990         


Ala Leu Gln Ala Arg Val Leu Gln  Leu Gln Gly Gln Gly  Val Gln Val 
        995                 1000                 1005             


<210>  442
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  442

Met Lys Asp Ser Pro Phe Gln Val Thr Lys Leu Tyr Trp Leu Asn Glu 
1               5                   10                  15      


Lys Trp Asp Phe Ile Ala Ser Ala Ser Asp Met Ala Ala Glu Gln Gly 
            20                  25                  30          


Gln Ile Leu Val Ile Ala Thr Ala Ala Val Gly Gly Phe Thr Leu Leu 
        35                  40                  45              


Val Ile Leu Thr Leu Phe Phe Leu Ile Thr Gly Arg Cys Gln Trp Tyr 
    50                  55                  60                  


Ile Lys Ala Lys Met Lys Ser Glu Glu Lys Arg Arg Asn His Leu Gln 
65                  70                  75                  80  


Asn Gly His Leu Arg Phe Pro Gly Ile Lys Thr Tyr Ile Asp Pro Asp 
                85                  90                  95      


Thr Tyr Glu Asp Pro Ser Leu Ala Val His Glu Phe Ala Lys Glu Ile 
            100                 105                 110         


Asp Pro Ser Arg Ile Arg Ile Glu Arg Val Ile Gly Ala Gly Glu Phe 
        115                 120                 125             


Gly Glu Val Cys Ser Gly Arg Leu Lys Thr Pro Gly Lys Arg Glu Ile 
    130                 135                 140                 


Pro Val Ala Ile Lys Thr Leu Lys Gly Gly His Met Asp Arg Gln Arg 
145                 150                 155                 160 


Arg Asp Phe Leu Arg Glu Ala Ser Ile Met Gly Gln Phe Asp His Pro 
                165                 170                 175     


Asn Ile Ile Arg Leu Glu Gly Val Val Thr Lys Arg Ser Phe Pro Ala 
            180                 185                 190         


Ile Gly Val Glu Ala Phe Cys Pro Ser Phe Leu Arg Ala Gly Phe Leu 
        195                 200                 205             


Asn Ser Ile Gln Ala Pro His Pro Val Pro Gly Gly Gly Ser Leu Pro 
    210                 215                 220                 


Pro Arg Ile Pro Ala Gly Arg Pro Val Met Ile Val Val Glu Tyr Met 
225                 230                 235                 240 


Glu Asn Gly Ser Leu Asp Ser Phe Leu Arg Lys His Asp Gly His Phe 
                245                 250                 255     


Thr Val Ile Gln Leu Val Gly Met Leu Arg Gly Ile Ala Ser Gly Met 
            260                 265                 270         


Lys Tyr Leu Ser Asp Met Gly Tyr Val His Arg Asp Leu Ala Ala Arg 
        275                 280                 285             


Asn Ile Leu Val Asn Ser Asn Leu Val Cys Lys Val Ser Asp Phe Gly 
    290                 295                 300                 


Leu Ser Arg Val Leu Glu Asp Asp Pro Glu Ala Ala Tyr Thr Thr Thr 
305                 310                 315                 320 


Arg Pro Thr Asn His Asn Lys Glu Gln Ser Glu Leu Val Lys Glu Asp 
                325                 330                 335     


Gly Leu Glu Ser Leu Cys Glu Gln Cys Glu Ser Ser Ser Gly Tyr Gly 
            340                 345                 350         


Thr Gly Leu Val Leu Met Trp Lys Arg Asn Arg Arg Ala Met Gly Ala 
        355                 360                 365             


Ser Gly Gln Thr Arg Lys Gln Cys Asp Lys Arg Asp Asn Pro Pro Thr 
    370                 375                 380                 


Asp Leu Phe Gln Thr Leu Thr Leu Asn Leu Cys Tyr Ser Ala 
385                 390                 395             


<210>  443
<211>  1367
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  444
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  444

Met Ala Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


<210>  445
<211>  1297
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Ala Val Pro Ser Leu Trp Pro Trp Gly Ala Cys Leu Pro Val Ile 
1               5                   10                  15      


Phe Leu Ser Leu Gly Phe Gly Leu Asp Thr Val Glu Val Cys Pro Ser 
            20                  25                  30          


Leu Asp Ile Arg Ser Glu Val Ala Glu Leu Arg Gln Leu Glu Asn Cys 
        35                  40                  45              


Ser Val Val Glu Gly His Leu Gln Ile Leu Leu Met Phe Thr Ala Thr 
    50                  55                  60                  


Gly Glu Asp Phe Arg Gly Leu Ser Phe Pro Arg Leu Thr Gln Val Thr 
65                  70                  75                  80  


Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu Glu Ser Leu Arg Asp 
                85                  90                  95      


Leu Phe Pro Asn Leu Ala Val Ile Arg Gly Thr Arg Leu Phe Leu Gly 
            100                 105                 110         


Tyr Ala Leu Val Ile Phe Glu Met Pro His Leu Arg Asp Val Ala Leu 
        115                 120                 125             


Pro Ala Leu Gly Ala Val Leu Arg Gly Ala Val Arg Val Glu Lys Asn 
    130                 135                 140                 


Gln Glu Leu Cys His Leu Ser Thr Ile Asp Trp Gly Leu Leu Gln Pro 
145                 150                 155                 160 


Ala Pro Gly Ala Asn His Ile Val Gly Asn Lys Leu Gly Glu Glu Cys 
                165                 170                 175     


Ala Asp Val Cys Pro Gly Val Leu Gly Ala Ala Gly Glu Pro Cys Ala 
            180                 185                 190         


Lys Thr Thr Phe Ser Gly His Thr Asp Tyr Arg Cys Trp Thr Ser Ser 
        195                 200                 205             


His Cys Gln Arg Val Cys Pro Cys Pro His Gly Met Ala Cys Thr Ala 
    210                 215                 220                 


Arg Gly Glu Cys Cys His Thr Glu Cys Leu Gly Gly Cys Ser Gln Pro 
225                 230                 235                 240 


Glu Asp Pro Arg Ala Cys Val Ala Cys Arg His Leu Tyr Phe Gln Gly 
                245                 250                 255     


Ala Cys Leu Trp Ala Cys Pro Pro Gly Thr Tyr Gln Tyr Glu Ser Trp 
            260                 265                 270         


Arg Cys Val Thr Ala Glu Arg Cys Ala Ser Leu His Ser Val Pro Gly 
        275                 280                 285             


Arg Ala Ser Thr Phe Gly Ile His Gln Gly Ser Cys Leu Ala Gln Cys 
    290                 295                 300                 


Pro Ser Gly Phe Thr Arg Asn Ser Ser Ser Ile Phe Cys His Lys Cys 
305                 310                 315                 320 


Glu Gly Leu Cys Pro Lys Glu Cys Lys Val Gly Thr Lys Thr Ile Asp 
                325                 330                 335     


Ser Ile Gln Ala Ala Gln Asp Leu Val Gly Cys Thr His Val Glu Gly 
            340                 345                 350         


Ser Leu Ile Leu Asn Leu Arg Gln Gly Tyr Asn Leu Glu Pro Gln Leu 
        355                 360                 365             


Gln His Ser Leu Gly Leu Val Glu Thr Ile Thr Gly Phe Leu Lys Ile 
    370                 375                 380                 


Lys His Ser Phe Ala Leu Val Ser Leu Gly Phe Phe Lys Asn Leu Lys 
385                 390                 395                 400 


Leu Ile Arg Gly Asp Ala Met Val Asp Gly Asn Tyr Thr Leu Tyr Val 
                405                 410                 415     


Leu Asp Asn Gln Asn Leu Gln Gln Leu Gly Ser Trp Val Ala Ala Gly 
            420                 425                 430         


Leu Thr Ile Pro Val Gly Lys Ile Tyr Phe Ala Phe Asn Pro Arg Leu 
        435                 440                 445             


Cys Leu Glu His Ile Tyr Arg Leu Glu Glu Val Thr Gly Thr Arg Gly 
    450                 455                 460                 


Arg Gln Asn Lys Ala Glu Ile Asn Pro Arg Thr Asn Gly Asp Arg Ala 
465                 470                 475                 480 


Ala Cys Gln Thr Arg Thr Leu Arg Phe Val Ser Asn Val Thr Glu Ala 
                485                 490                 495     


Asp Arg Ile Leu Leu Arg Trp Glu Arg Tyr Glu Pro Leu Glu Ala Arg 
            500                 505                 510         


Asp Leu Leu Ser Phe Ile Val Tyr Tyr Lys Glu Ser Pro Phe Gln Asn 
        515                 520                 525             


Ala Thr Glu His Val Gly Pro Asp Ala Cys Gly Thr Gln Ser Trp Asn 
    530                 535                 540                 


Leu Leu Asp Val Glu Leu Pro Leu Ser Arg Thr Gln Glu Pro Gly Val 
545                 550                 555                 560 


Thr Leu Ala Ser Leu Lys Pro Trp Thr Gln Tyr Ala Val Phe Val Arg 
                565                 570                 575     


Ala Ile Thr Leu Thr Thr Glu Glu Asp Ser Pro His Gln Gly Ala Gln 
            580                 585                 590         


Ser Pro Ile Val Tyr Leu Arg Thr Leu Pro Ala Ala Pro Thr Val Pro 
        595                 600                 605             


Gln Asp Val Ile Ser Thr Ser Asn Ser Ser Ser His Leu Leu Val Arg 
    610                 615                 620                 


Trp Lys Pro Pro Thr Gln Arg Asn Gly Asn Leu Thr Tyr Tyr Leu Val 
625                 630                 635                 640 


Leu Trp Gln Arg Leu Ala Glu Asp Gly Asp Leu Tyr Leu Asn Asp Tyr 
                645                 650                 655     


Cys His Arg Gly Leu Arg Leu Pro Thr Ser Asn Asn Asp Pro Arg Phe 
            660                 665                 670         


Asp Gly Glu Asp Gly Asp Pro Glu Ala Glu Met Glu Ser Asp Cys Cys 
        675                 680                 685             


Pro Cys Gln His Pro Pro Pro Gly Gln Val Leu Pro Pro Leu Glu Ala 
    690                 695                 700                 


Gln Glu Ala Ser Phe Gln Lys Lys Phe Glu Asn Phe Leu His Asn Ala 
705                 710                 715                 720 


Ile Thr Ile Pro Ile Ser Pro Trp Lys Val Thr Ser Ile Asn Lys Ser 
                725                 730                 735     


Pro Gln Arg Asp Ser Gly Arg His Arg Arg Ala Ala Gly Pro Leu Arg 
            740                 745                 750         


Leu Gly Gly Asn Ser Ser Asp Phe Glu Ile Gln Glu Asp Lys Val Pro 
        755                 760                 765             


Arg Glu Arg Ala Val Leu Ser Gly Leu Arg His Phe Thr Glu Tyr Arg 
    770                 775                 780                 


Ile Asp Ile His Ala Cys Asn His Ala Ala His Thr Val Gly Cys Ser 
785                 790                 795                 800 


Ala Ala Thr Phe Val Phe Ala Arg Thr Met Pro His Arg Glu Ala Asp 
                805                 810                 815     


Gly Ile Pro Gly Lys Val Ala Trp Glu Ala Ser Ser Lys Asn Ser Val 
            820                 825                 830         


Leu Leu Arg Trp Leu Glu Pro Pro Asp Pro Asn Gly Leu Ile Leu Lys 
        835                 840                 845             


Tyr Glu Ile Lys Tyr Arg Arg Leu Gly Glu Glu Ala Thr Val Leu Cys 
    850                 855                 860                 


Val Ser Arg Leu Arg Tyr Ala Lys Phe Gly Gly Val His Leu Ala Leu 
865                 870                 875                 880 


Leu Pro Pro Gly Asn Tyr Ser Ala Arg Val Arg Ala Thr Ser Leu Ala 
                885                 890                 895     


Gly Asn Gly Ser Trp Thr Asp Ser Val Ala Phe Tyr Ile Leu Gly Pro 
            900                 905                 910         


Glu Glu Glu Asp Ala Gly Gly Leu His Val Leu Leu Thr Ala Thr Pro 
        915                 920                 925             


Val Gly Leu Thr Leu Leu Ile Val Leu Ala Ala Leu Gly Phe Phe Tyr 
    930                 935                 940                 


Gly Lys Lys Arg Asn Arg Thr Leu Tyr Ala Ser Val Asn Pro Glu Tyr 
945                 950                 955                 960 


Phe Ser Ala Ser Asp Met Tyr Val Pro Asp Glu Trp Glu Val Pro Arg 
                965                 970                 975     


Glu Gln Ile Ser Ile Ile Arg Glu Leu Gly Gln Gly Ser Phe Gly Met 
            980                 985                 990         


Val Tyr Glu Gly Leu Ala Arg Gly  Leu Glu Ala Gly Glu  Glu Ser Thr 
        995                 1000                 1005             


Pro Val  Ala Leu Lys Thr Val  Asn Glu Leu Ala Ser  Pro Arg Glu 
    1010                 1015                 1020             


Cys Ile  Glu Phe Leu Lys Glu  Ala Ser Val Met Lys  Ala Phe Lys 
    1025                 1030                 1035             


Cys His  His Val Val Arg Leu  Leu Gly Val Val Ser  Gln Gly Gln 
    1040                 1045                 1050             


Pro Thr  Leu Val Ile Met Glu  Leu Met Thr Arg Gly  Asp Leu Lys 
    1055                 1060                 1065             


Ser His  Leu Arg Ser Leu Arg  Pro Glu Ala Glu Asn  Asn Pro Gly 
    1070                 1075                 1080             


Leu Pro  Gln Pro Ala Leu Gly  Glu Met Ile Gln Met  Ala Gly Glu 
    1085                 1090                 1095             


Ile Ala  Asp Gly Met Ala Tyr  Leu Ala Ala Asn Lys  Phe Val His 
    1100                 1105                 1110             


Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val Ser Gln  Asp Phe Thr 
    1115                 1120                 1125             


Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg Asp Val  Tyr Glu Thr 
    1130                 1135                 1140             


Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu Leu Pro  Val Arg Trp 
    1145                 1150                 1155             


Met Ala  Pro Glu Ser Leu Lys  Asp Gly Ile Phe Thr  Thr His Ser 
    1160                 1165                 1170             


Asp Val  Trp Ser Phe Gly Val  Val Leu Trp Glu Ile  Val Thr Leu 
    1175                 1180                 1185             


Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Lys 
    1190                 1195                 1200             


Phe Val  Met Asp Gly Gly Val  Leu Glu Glu Leu Glu  Gly Cys Pro 
    1205                 1210                 1215             


Leu Gln  Leu Gln Glu Leu Met  Ser Arg Cys Trp Gln  Pro Asn Pro 
    1220                 1225                 1230             


Arg Leu  Arg Pro Ser Phe Thr  His Ile Leu Asp Ser  Ile Gln Glu 
    1235                 1240                 1245             


Glu Leu  Arg Pro Ser Phe Arg  Leu Leu Ser Phe Tyr  Tyr Ser Pro 
    1250                 1255                 1260             


Glu Cys  Arg Gly Ala Arg Gly  Ser Leu Pro Thr Thr  Asp Ala Glu 
    1265                 1270                 1275             


Pro Asp  Ser Ser Pro Thr Pro  Arg Asp Cys Ser Pro  Gln Asn Gly 
    1280                 1285                 1290             


Gly Pro  Gly His 
    1295         


<210>  446
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  446

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  447
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  447

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  448
<211>  864
<212>  PRT
<213>  Homo sapiens

<400>  448

Met Gly Cys Trp Gly Gln Leu Leu Val Trp Phe Gly Ala Ala Gly Ala 
1               5                   10                  15      


Ile Leu Cys Ser Ser Pro Gly Ser Gln Glu Thr Phe Leu Arg Ser Ser 
            20                  25                  30          


Pro Leu Pro Leu Ala Ser Pro Ser Pro Arg Asp Pro Lys Val Ser Ala 
        35                  40                  45              


Pro Pro Ser Ile Leu Glu Pro Ala Ser Pro Leu Asn Ser Pro Gly Thr 
    50                  55                  60                  


Glu Gly Ser Trp Leu Phe Ser Thr Cys Gly Ala Ser Gly Arg His Gly 
65                  70                  75                  80  


Pro Thr Gln Thr Gln Cys Asp Gly Ala Tyr Ala Gly Thr Ser Val Val 
                85                  90                  95      


Val Thr Val Gly Ala Ala Gly Gln Leu Arg Gly Val Gln Leu Trp Arg 
            100                 105                 110         


Val Pro Gly Pro Gly Gln Tyr Leu Ile Ser Ala Tyr Gly Ala Ala Gly 
        115                 120                 125             


Gly Lys Gly Ala Lys Asn His Leu Ser Arg Ala His Gly Val Phe Val 
    130                 135                 140                 


Ser Ala Ile Phe Ser Leu Gly Leu Gly Glu Ser Leu Tyr Ile Leu Val 
145                 150                 155                 160 


Gly Gln Gln Gly Glu Asp Ala Cys Pro Gly Gly Ser Pro Glu Ser Gln 
                165                 170                 175     


Leu Val Cys Leu Gly Glu Ser Arg Ala Val Glu Glu His Ala Ala Met 
            180                 185                 190         


Asp Gly Ser Glu Gly Val Pro Gly Ser Arg Arg Trp Ala Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Arg Val Arg Ala Gly Glu 
    210                 215                 220                 


Leu Glu Pro Leu Leu Val Ala Ala Gly Gly Gly Gly Arg Ala Tyr Leu 
225                 230                 235                 240 


Arg Pro Arg Asp Arg Gly Arg Thr Gln Ala Ser Pro Glu Lys Leu Glu 
                245                 250                 255     


Asn Arg Ser Glu Ala Pro Gly Ser Gly Gly Arg Gly Gly Ala Ala Gly 
            260                 265                 270         


Gly Gly Gly Gly Trp Thr Ser Arg Ala Pro Ser Pro Gln Ala Gly Arg 
        275                 280                 285             


Ser Leu Gln Glu Gly Ala Glu Gly Gly Gln Gly Cys Ser Glu Ala Trp 
    290                 295                 300                 


Ala Thr Leu Gly Trp Ala Ala Ala Gly Gly Phe Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Cys Thr Ala Gly Gly Gly Gly Gly Gly Tyr Arg Gly Gly Asp Ala 
                325                 330                 335     


Ser Glu Thr Asp Asn Leu Trp Ala Asp Gly Glu Asp Gly Val Ser Phe 
            340                 345                 350         


Ile His Pro Ser Ser Glu Leu Phe Leu Gln Pro Leu Ala Val Thr Glu 
        355                 360                 365             


Asn His Gly Glu Val Glu Ile Arg Arg His Leu Asn Cys Ser His Cys 
    370                 375                 380                 


Pro Leu Arg Asp Cys Gln Trp Gln Ala Glu Leu Gln Leu Ala Glu Cys 
385                 390                 395                 400 


Leu Cys Pro Glu Gly Met Glu Leu Ala Val Asp Asn Val Thr Cys Met 
                405                 410                 415     


Asp Leu His Lys Pro Pro Gly Pro Leu Val Leu Met Val Ala Val Val 
            420                 425                 430         


Ala Thr Ser Thr Leu Ser Leu Leu Met Val Cys Gly Val Leu Ile Leu 
        435                 440                 445             


Val Lys Gln Lys Lys Trp Gln Gly Leu Gln Glu Met Arg Leu Pro Ser 
    450                 455                 460                 


Pro Glu Leu Glu Leu Ser Lys Leu Arg Thr Ser Ala Ile Arg Thr Ala 
465                 470                 475                 480 


Pro Asn Pro Tyr Tyr Cys Gln Val Gly Leu Gly Pro Ala Gln Ser Trp 
                485                 490                 495     


Pro Leu Pro Pro Gly Val Thr Glu Val Ser Pro Ala Asn Val Thr Leu 
            500                 505                 510         


Leu Arg Ala Leu Gly His Gly Ala Phe Gly Glu Val Tyr Glu Gly Leu 
        515                 520                 525             


Val Ile Gly Leu Pro Gly Asp Ser Ser Pro Leu Gln Val Ala Ile Lys 
    530                 535                 540                 


Thr Leu Pro Glu Leu Cys Ser Pro Gln Asp Glu Leu Asp Phe Leu Met 
545                 550                 555                 560 


Glu Ala Leu Ile Ile Ser Lys Phe Arg His Gln Asn Ile Val Arg Cys 
                565                 570                 575     


Val Gly Leu Ser Leu Arg Ala Thr Pro Arg Leu Ile Leu Leu Glu Leu 
            580                 585                 590         


Met Ser Gly Gly Asp Met Lys Ser Phe Leu Arg His Ser Arg Pro His 
        595                 600                 605             


Leu Gly Gln Pro Ser Pro Leu Val Met Arg Asp Leu Leu Gln Leu Ala 
    610                 615                 620                 


Gln Asp Ile Ala Gln Gly Cys His Tyr Leu Glu Glu Asn His Phe Ile 
625                 630                 635                 640 


His Arg Asp Ile Ala Ala Arg Asn Cys Leu Leu Ser Cys Ala Gly Pro 
                645                 650                 655     


Ser Arg Val Ala Lys Ile Gly Asp Phe Gly Met Ala Arg Asp Ile Tyr 
            660                 665                 670         


Arg Ala Ser Tyr Tyr Arg Arg Gly Asp Arg Ala Leu Leu Pro Val Lys 
        675                 680                 685             


Trp Met Pro Pro Glu Ala Phe Leu Glu Gly Ile Phe Thr Ser Lys Thr 
    690                 695                 700                 


Asp Ser Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Ser Leu Gly 
705                 710                 715                 720 


Tyr Met Pro Tyr Pro Gly Arg Thr Asn Gln Glu Val Leu Asp Phe Val 
                725                 730                 735     


Val Gly Gly Gly Arg Met Asp Pro Pro Arg Gly Cys Pro Gly Pro Val 
            740                 745                 750         


Tyr Arg Ile Met Thr Gln Cys Trp Gln His Glu Pro Glu Leu Arg Pro 
        755                 760                 765             


Ser Phe Ala Ser Ile Leu Glu Arg Leu Gln Tyr Cys Thr Gln Asp Pro 
    770                 775                 780                 


Asp Val Leu Asn Ser Leu Leu Pro Met Glu Leu Gly Pro Thr Pro Glu 
785                 790                 795                 800 


Glu Glu Gly Thr Ser Gly Leu Gly Asn Arg Ser Leu Glu Cys Leu Arg 
                805                 810                 815     


Pro Pro Gln Pro Gln Glu Leu Ser Pro Glu Lys Leu Lys Ser Trp Gly 
            820                 825                 830         


Gly Ser Pro Leu Gly Pro Trp Leu Ser Ser Gly Leu Lys Pro Leu Lys 
        835                 840                 845             


Ser Arg Gly Leu Gln Pro Gln Asn Leu Trp Asn Pro Thr Tyr Arg Ser 
    850                 855                 860                 


<210>  449
<211>  1390
<212>  PRT
<213>  Homo sapiens

<400>  449

Met Lys Ala Pro Ala Val Leu Ala Pro Gly Ile Leu Val Leu Leu Phe 
1               5                   10                  15      


Thr Leu Val Gln Arg Ser Asn Gly Glu Cys Lys Glu Ala Leu Ala Lys 
            20                  25                  30          


Ser Glu Met Asn Val Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala 
        35                  40                  45              


Glu Thr Pro Ile Gln Asn Val Ile Leu His Glu His His Ile Phe Leu 
    50                  55                  60                  


Gly Ala Thr Asn Tyr Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys 
65                  70                  75                  80  


Val Ala Glu Tyr Lys Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe 
                85                  90                  95      


Pro Cys Gln Asp Cys Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp 
            100                 105                 110         


Lys Asp Asn Ile Asn Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp 
        115                 120                 125             


Gln Leu Ile Ser Cys Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His 
    130                 135                 140                 


Val Phe Pro His Asn His Thr Ala Asp Ile Gln Ser Glu Val His Cys 
145                 150                 155                 160 


Ile Phe Ser Pro Gln Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val 
                165                 170                 175     


Val Ser Ala Leu Gly Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe 
            180                 185                 190         


Ile Asn Phe Phe Val Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp 
        195                 200                 205             


His Pro Leu His Ser Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp 
    210                 215                 220                 


Gly Phe Met Phe Leu Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu 
225                 230                 235                 240 


Phe Arg Asp Ser Tyr Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn 
                245                 250                 255     


Asn Phe Ile Tyr Phe Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln 
            260                 265                 270         


Thr Phe His Thr Arg Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu 
        275                 280                 285             


His Ser Tyr Met Glu Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg 
    290                 295                 300                 


Lys Lys Arg Ser Thr Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala 
305                 310                 315                 320 


Tyr Val Ser Lys Pro Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser 
                325                 330                 335     


Leu Asn Asp Asp Ile Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp 
            340                 345                 350         


Ser Ala Glu Pro Met Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys 
        355                 360                 365             


Tyr Val Asn Asp Phe Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg 
    370                 375                 380                 


Cys Leu Gln His Phe Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg 
385                 390                 395                 400 


Thr Leu Leu Arg Asn Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr 
                405                 410                 415     


Arg Thr Glu Phe Thr Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly 
            420                 425                 430         


Gln Phe Ser Glu Val Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly 
        435                 440                 445             


Asp Leu Thr Ile Ala Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln 
    450                 455                 460                 


Val Val Val Ser Arg Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu 
465                 470                 475                 480 


Leu Asp Ser His Pro Val Ser Pro Glu Val Ile Val Glu His Thr Leu 
                485                 490                 495     


Asn Gln Asn Gly Tyr Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys 
            500                 505                 510         


Ile Pro Leu Asn Gly Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln 
        515                 520                 525             


Cys Leu Ser Ala Pro Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys 
    530                 535                 540                 


Cys Val Arg Ser Glu Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile 
545                 550                 555                 560 


Cys Leu Pro Ala Ile Tyr Lys Val Phe Pro Asn Ser Ala Pro Leu Glu 
                565                 570                 575     


Gly Gly Thr Arg Leu Thr Ile Cys Gly Trp Asp Phe Gly Phe Arg Arg 
            580                 585                 590         


Asn Asn Lys Phe Asp Leu Lys Lys Thr Arg Val Leu Leu Gly Asn Glu 
        595                 600                 605             


Ser Cys Thr Leu Thr Leu Ser Glu Ser Thr Met Asn Thr Leu Lys Cys 
    610                 615                 620                 


Thr Val Gly Pro Ala Met Asn Lys His Phe Asn Met Ser Ile Ile Ile 
625                 630                 635                 640 


Ser Asn Gly His Gly Thr Thr Gln Tyr Ser Thr Phe Ser Tyr Val Asp 
                645                 650                 655     


Pro Val Ile Thr Ser Ile Ser Pro Lys Tyr Gly Pro Met Ala Gly Gly 
            660                 665                 670         


Thr Leu Leu Thr Leu Thr Gly Asn Tyr Leu Asn Ser Gly Asn Ser Arg 
        675                 680                 685             


His Ile Ser Ile Gly Gly Lys Thr Cys Thr Leu Lys Ser Val Ser Asn 
    690                 695                 700                 


Ser Ile Leu Glu Cys Tyr Thr Pro Ala Gln Thr Ile Ser Thr Glu Phe 
705                 710                 715                 720 


Ala Val Lys Leu Lys Ile Asp Leu Ala Asn Arg Glu Thr Ser Ile Phe 
                725                 730                 735     


Ser Tyr Arg Glu Asp Pro Ile Val Tyr Glu Ile His Pro Thr Lys Ser 
            740                 745                 750         


Phe Ile Ser Gly Gly Ser Thr Ile Thr Gly Val Gly Lys Asn Leu Asn 
        755                 760                 765             


Ser Val Ser Val Pro Arg Met Val Ile Asn Val His Glu Ala Gly Arg 
    770                 775                 780                 


Asn Phe Thr Val Ala Cys Gln His Arg Ser Asn Ser Glu Ile Ile Cys 
785                 790                 795                 800 


Cys Thr Thr Pro Ser Leu Gln Gln Leu Asn Leu Gln Leu Pro Leu Lys 
                805                 810                 815     


Thr Lys Ala Phe Phe Met Leu Asp Gly Ile Leu Ser Lys Tyr Phe Asp 
            820                 825                 830         


Leu Ile Tyr Val His Asn Pro Val Phe Lys Pro Phe Glu Lys Pro Val 
        835                 840                 845             


Met Ile Ser Met Gly Asn Glu Asn Val Leu Glu Ile Lys Gly Asn Asp 
    850                 855                 860                 


Ile Asp Pro Glu Ala Val Lys Gly Glu Val Leu Lys Val Gly Asn Lys 
865                 870                 875                 880 


Ser Cys Glu Asn Ile His Leu His Ser Glu Ala Val Leu Cys Thr Val 
                885                 890                 895     


Pro Asn Asp Leu Leu Lys Leu Asn Ser Glu Leu Asn Ile Glu Trp Lys 
            900                 905                 910         


Gln Ala Ile Ser Ser Thr Val Leu Gly Lys Val Ile Val Gln Pro Asp 
        915                 920                 925             


Gln Asn Phe Thr Gly Leu Ile Ala Gly Val Val Ser Ile Ser Thr Ala 
    930                 935                 940                 


Leu Leu Leu Leu Leu Gly Phe Phe Leu Trp Leu Lys Lys Arg Lys Gln 
945                 950                 955                 960 


Ile Lys Asp Leu Gly Ser Glu Leu Val Arg Tyr Asp Ala Arg Val His 
                965                 970                 975     


Thr Pro His Leu Asp Arg Leu Val Ser Ala Arg Ser Val Ser Pro Thr 
            980                 985                 990         


Thr Glu Met Val Ser Asn Glu Ser  Val Asp Tyr Arg Ala  Thr Phe Pro 
        995                 1000                 1005             


Glu Asp  Gln Phe Pro Asn Ser  Ser Gln Asn Gly Ser  Cys Arg Gln 
    1010                 1015                 1020             


Val Gln  Tyr Pro Leu Thr Asp  Met Ser Pro Ile Leu  Thr Ser Gly 
    1025                 1030                 1035             


Asp Ser  Asp Ile Ser Ser Pro  Leu Leu Gln Asn Thr  Val His Ile 
    1040                 1045                 1050             


Asp Leu  Ser Ala Leu Asn Pro  Glu Leu Val Gln Ala  Val Gln His 
    1055                 1060                 1065             


Val Val  Ile Gly Pro Ser Ser  Leu Ile Val His Phe  Asn Glu Val 
    1070                 1075                 1080             


Ile Gly  Arg Gly His Phe Gly  Cys Val Tyr His Gly  Thr Leu Leu 
    1085                 1090                 1095             


Asp Asn  Asp Gly Lys Lys Ile  His Cys Ala Val Lys  Ser Leu Asn 
    1100                 1105                 1110             


Arg Ile  Thr Asp Ile Gly Glu  Val Ser Gln Phe Leu  Thr Glu Gly 
    1115                 1120                 1125             


Ile Ile  Met Lys Asp Phe Ser  His Pro Asn Val Leu  Ser Leu Leu 
    1130                 1135                 1140             


Gly Ile  Cys Leu Arg Ser Glu  Gly Ser Pro Leu Val  Val Leu Pro 
    1145                 1150                 1155             


Tyr Met  Lys His Gly Asp Leu  Arg Asn Phe Ile Arg  Asn Glu Thr 
    1160                 1165                 1170             


His Asn  Pro Thr Val Lys Asp  Leu Ile Gly Phe Gly  Leu Gln Val 
    1175                 1180                 1185             


Ala Lys  Gly Met Lys Tyr Leu  Ala Ser Lys Lys Phe  Val His Arg 
    1190                 1195                 1200             


Asp Leu  Ala Ala Arg Asn Cys  Met Leu Asp Glu Lys  Phe Thr Val 
    1205                 1210                 1215             


Lys Val  Ala Asp Phe Gly Leu  Ala Arg Asp Met Tyr  Asp Lys Glu 
    1220                 1225                 1230             


Tyr Tyr  Ser Val His Asn Lys  Thr Gly Ala Lys Leu  Pro Val Lys 
    1235                 1240                 1245             


Trp Met  Ala Leu Glu Ser Leu  Gln Thr Gln Lys Phe  Thr Thr Lys 
    1250                 1255                 1260             


Ser Asp  Val Trp Ser Phe Gly  Val Leu Leu Trp Glu  Leu Met Thr 
    1265                 1270                 1275             


Arg Gly  Ala Pro Pro Tyr Pro  Asp Val Asn Thr Phe  Asp Ile Thr 
    1280                 1285                 1290             


Val Tyr  Leu Leu Gln Gly Arg  Arg Leu Leu Gln Pro  Glu Tyr Cys 
    1295                 1300                 1305             


Pro Asp  Pro Leu Tyr Glu Val  Met Leu Lys Cys Trp  His Pro Lys 
    1310                 1315                 1320             


Ala Glu  Met Arg Pro Ser Phe  Ser Glu Leu Val Ser  Arg Ile Ser 
    1325                 1330                 1335             


Ala Ile  Phe Ser Thr Phe Ile  Gly Glu His Tyr Val  His Val Asn 
    1340                 1345                 1350             


Ala Thr  Tyr Val Asn Val Lys  Cys Val Ala Pro Tyr  Pro Ser Leu 
    1355                 1360                 1365             


Leu Ser  Ser Glu Asp Asn Ala  Asp Asp Glu Val Asp  Thr Arg Pro 
    1370                 1375                 1380             


Ala Ser  Phe Trp Glu Thr Ser  
    1385                 1390 


<210>  450
<211>  1400
<212>  PRT
<213>  Homo sapiens

<400>  450

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala 
        675                 680                 685             


Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu 
    690                 695                 700                 


Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn 
705                 710                 715                 720 


Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys 
                725                 730                 735     


Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln 
            740                 745                 750         


Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu 
        755                 760                 765             


Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser 
    770                 775                 780                 


His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val 
785                 790                 795                 800 


Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg 
                805                 810                 815     


Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg 
            820                 825                 830         


Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly 
        835                 840                 845             


Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His 
    850                 855                 860                 


Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile 
865                 870                 875                 880 


Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile 
                885                 890                 895     


Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp 
            900                 905                 910         


Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly 
        915                 920                 925             


Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg 
    930                 935                 940                 


Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly 
945                 950                 955                 960 


Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu 
                965                 970                 975     


Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn 
            980                 985                 990         


Leu Asn Asp Leu Ala Ser Leu Asp  Gln Thr Ala Gly Ala  Thr Pro Leu 
        995                 1000                 1005             


Pro Ile  Leu Tyr Ser Gly Ser  Asp Tyr Arg Ser Gly  Leu Ala Leu 
    1010                 1015                 1020             


Pro Ala  Ile Asp Gly Leu Asp  Ser Thr Thr Cys Val  His Gly Ala 
    1025                 1030                 1035             


Ser Phe  Ser Asp Ser Glu Asp  Glu Ser Cys Val Pro  Leu Leu Arg 
    1040                 1045                 1050             


Lys Glu  Ser Ile Gln Leu Arg  Asp Leu Asp Ser Ala  Leu Leu Ala 
    1055                 1060                 1065             


Glu Val  Lys Asp Val Leu Ile  Pro His Glu Arg Val  Val Thr His 
    1070                 1075                 1080             


Ser Asp  Arg Val Ile Gly Lys  Gly His Phe Gly Val  Val Tyr His 
    1085                 1090                 1095             


Gly Glu  Tyr Ile Asp Gln Ala  Gln Asn Arg Ile Gln  Cys Ala Ile 
    1100                 1105                 1110             


Lys Ser  Leu Ser Arg Ile Thr  Glu Met Gln Gln Val  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Glu Gly Leu Leu Met  Arg Gly Leu Asn His  Pro Asn Val 
    1130                 1135                 1140             


Leu Ala  Leu Ile Gly Ile Met  Leu Pro Pro Glu Gly  Leu Pro His 
    1145                 1150                 1155             


Val Leu  Leu Pro Tyr Met Cys  His Gly Asp Leu Leu  Gln Phe Ile 
    1160                 1165                 1170             


Arg Ser  Pro Gln Arg Asn Pro  Thr Val Lys Asp Leu  Ile Ser Phe 
    1175                 1180                 1185             


Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Glu Gln Lys 
    1190                 1195                 1200             


Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu 
    1205                 1210                 1215             


Ser Phe  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1220                 1225                 1230             


Leu Asp  Arg Glu Tyr Tyr Ser  Val Gln Gln His Arg  His Ala Arg 
    1235                 1240                 1245             


Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp 
    1265                 1270                 1275             


Glu Leu  Leu Thr Arg Gly Ala  Pro Pro Tyr Arg His  Ile Asp Pro 
    1280                 1285                 1290             


Phe Asp  Leu Thr His Phe Leu  Ala Gln Gly Arg Arg  Leu Pro Gln 
    1295                 1300                 1305             


Pro Glu  Tyr Cys Pro Asp Ser  Leu Tyr Gln Val Met  Gln Gln Cys 
    1310                 1315                 1320             


Trp Glu  Ala Asp Pro Ala Val  Arg Pro Thr Phe Arg  Val Leu Val 
    1325                 1330                 1335             


Gly Glu  Val Glu Gln Ile Val  Ser Ala Leu Leu Gly  Asp His Tyr 
    1340                 1345                 1350             


Val Gln  Leu Pro Ala Thr Tyr  Met Asn Leu Gly Pro  Ser Thr Ser 
    1355                 1360                 1365             


His Glu  Met Asn Val Arg Pro  Glu Gln Pro Gln Phe  Ser Pro Met 
    1370                 1375                 1380             


Pro Gly  Asn Val Arg Arg Pro  Arg Pro Leu Ser Glu  Pro Pro Arg 
    1385                 1390                 1395             


Pro Thr  
    1400 


<210>  451
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  451

Met Arg Glu Leu Val Asn Ile Pro Leu Val His Ile Leu Thr Leu Val 
1               5                   10                  15      


Ala Phe Ser Gly Thr Glu Lys Leu Pro Lys Ala Pro Val Ile Thr Thr 
            20                  25                  30          


Pro Leu Glu Thr Val Asp Ala Leu Val Glu Glu Val Ala Thr Phe Met 
        35                  40                  45              


Cys Ala Val Glu Ser Tyr Pro Gln Pro Glu Ile Ser Trp Thr Arg Asn 
    50                  55                  60                  


Lys Ile Leu Ile Lys Leu Phe Asp Thr Arg Tyr Ser Ile Arg Glu Asn 
65                  70                  75                  80  


Gly Gln Leu Leu Thr Ile Leu Ser Val Glu Asp Ser Asp Asp Gly Ile 
                85                  90                  95      


Tyr Cys Cys Thr Ala Asn Asn Gly Val Gly Gly Ala Val Glu Ser Cys 
            100                 105                 110         


Gly Ala Leu Gln Val Lys Met Lys Pro Lys Ile Thr Arg Pro Pro Ile 
        115                 120                 125             


Asn Val Lys Ile Ile Glu Gly Leu Lys Ala Val Leu Pro Cys Thr Thr 
    130                 135                 140                 


Met Gly Asn Pro Lys Pro Ser Val Ser Trp Ile Lys Gly Asp Ser Pro 
145                 150                 155                 160 


Leu Arg Glu Asn Ser Arg Ile Ala Val Leu Glu Ser Gly Ser Leu Arg 
                165                 170                 175     


Ile His Asn Val Gln Lys Glu Asp Ala Gly Gln Tyr Arg Cys Val Ala 
            180                 185                 190         


Lys Asn Ser Leu Gly Thr Ala Tyr Ser Lys Val Val Lys Leu Glu Val 
        195                 200                 205             


Glu Val Phe Ala Arg Ile Leu Arg Ala Pro Glu Ser His Asn Val Thr 
    210                 215                 220                 


Phe Gly Ser Phe Val Thr Leu His Cys Thr Ala Thr Gly Ile Pro Val 
225                 230                 235                 240 


Pro Thr Ile Thr Trp Ile Glu Asn Gly Asn Ala Val Ser Ser Gly Ser 
                245                 250                 255     


Ile Gln Glu Ser Val Lys Asp Arg Val Ile Asp Ser Arg Leu Gln Leu 
            260                 265                 270         


Phe Ile Thr Lys Pro Gly Leu Tyr Thr Cys Ile Ala Thr Asn Lys His 
        275                 280                 285             


Gly Glu Lys Phe Ser Thr Ala Lys Ala Ala Ala Thr Ile Ser Ile Ala 
    290                 295                 300                 


Glu Trp Ser Lys Pro Gln Lys Asp Asn Lys Gly Tyr Cys Ala Gln Tyr 
305                 310                 315                 320 


Arg Gly Glu Val Cys Asn Ala Val Leu Ala Lys Asp Ala Leu Val Phe 
                325                 330                 335     


Leu Asn Thr Ser Tyr Ala Asp Pro Glu Glu Ala Gln Glu Leu Leu Val 
            340                 345                 350         


His Thr Ala Trp Asn Glu Leu Lys Val Val Ser Pro Val Cys Arg Pro 
        355                 360                 365             


Ala Ala Glu Ala Leu Leu Cys Asn His Ile Phe Gln Glu Cys Ser Pro 
    370                 375                 380                 


Gly Val Val Pro Thr Pro Ile Pro Ile Cys Arg Glu Tyr Cys Leu Ala 
385                 390                 395                 400 


Val Lys Glu Leu Phe Cys Ala Lys Glu Trp Leu Val Met Glu Glu Lys 
                405                 410                 415     


Thr His Arg Gly Leu Tyr Arg Ser Glu Met His Leu Leu Ser Val Pro 
            420                 425                 430         


Glu Cys Ser Lys Leu Pro Ser Met His Trp Asp Pro Thr Ala Cys Ala 
        435                 440                 445             


Arg Leu Pro His Leu Asp Tyr Asn Lys Glu Asn Leu Lys Thr Phe Pro 
    450                 455                 460                 


Pro Met Thr Ser Ser Lys Pro Ser Val Asp Ile Pro Asn Leu Pro Ser 
465                 470                 475                 480 


Ser Ser Ser Ser Ser Phe Ser Val Ser Pro Thr Tyr Ser Met Thr Val 
                485                 490                 495     


Ile Ile Ser Ile Met Ser Ser Phe Ala Ile Phe Val Leu Leu Thr Ile 
            500                 505                 510         


Thr Thr Leu Tyr Cys Cys Arg Arg Arg Lys Gln Trp Lys Asn Lys Lys 
        515                 520                 525             


Arg Glu Ser Ala Ala Val Thr Leu Thr Thr Leu Pro Ser Glu Leu Leu 
    530                 535                 540                 


Leu Asp Arg Leu His Pro Asn Pro Met Tyr Gln Arg Met Pro Leu Leu 
545                 550                 555                 560 


Leu Asn Pro Lys Leu Leu Ser Leu Glu Tyr Pro Arg Asn Asn Ile Glu 
                565                 570                 575     


Tyr Val Arg Asp Ile Gly Glu Gly Ala Phe Gly Arg Val Phe Gln Ala 
            580                 585                 590         


Arg Ala Pro Gly Leu Leu Pro Tyr Glu Pro Phe Thr Met Val Ala Val 
        595                 600                 605             


Lys Met Leu Lys Glu Glu Ala Ser Ala Asp Met Gln Ala Asp Phe Gln 
    610                 615                 620                 


Arg Glu Ala Ala Leu Met Ala Glu Phe Asp Asn Pro Asn Ile Val Lys 
625                 630                 635                 640 


Leu Leu Gly Val Cys Ala Val Gly Lys Pro Met Cys Leu Leu Phe Glu 
                645                 650                 655     


Tyr Met Ala Tyr Gly Asp Leu Asn Glu Phe Leu Arg Ser Met Ser Pro 
            660                 665                 670         


His Thr Val Cys Ser Leu Ser His Ser Asp Leu Ser Met Arg Ala Gln 
        675                 680                 685             


Val Ser Ser Pro Gly Pro Pro Pro Leu Ser Cys Ala Glu Gln Leu Cys 
    690                 695                 700                 


Ile Ala Arg Gln Val Ala Ala Gly Met Ala Tyr Leu Ser Glu Arg Lys 
705                 710                 715                 720 


Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn 
                725                 730                 735     


Met Val Val Lys Ile Ala Asp Phe Gly Leu Ser Arg Asn Ile Tyr Ser 
            740                 745                 750         


Ala Asp Tyr Tyr Lys Ala Asn Glu Asn Asp Ala Ile Pro Ile Arg Trp 
        755                 760                 765             


Met Pro Pro Glu Ser Ile Phe Tyr Asn Arg Tyr Thr Thr Glu Ser Asp 
    770                 775                 780                 


Val Trp Ala Tyr Gly Val Val Leu Trp Glu Ile Phe Ser Tyr Gly Leu 
785                 790                 795                 800 


Gln Pro Tyr Tyr Gly Met Ala His Glu Glu Val Ile Tyr Tyr Val Arg 
                805                 810                 815     


Asp Gly Asn Ile Leu Ser Cys Pro Glu Asn Cys Pro Val Glu Leu Tyr 
            820                 825                 830         


Asn Leu Met Arg Leu Cys Trp Ser Lys Leu Pro Ala Asp Arg Pro Ser 
        835                 840                 845             


Phe Thr Ser Ile His Arg Ile Leu Glu Arg Met Cys Glu Arg Ala Glu 
    850                 855                 860                 


Gly Thr Val Ser Val 
865                 


<210>  452
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  452

Met Leu Arg Gly Gly Arg Arg Gly Gln Leu Gly Trp His Ser Trp Ala 
1               5                   10                  15      


Ala Gly Pro Gly Ser Leu Leu Ala Trp Leu Ile Leu Ala Ser Ala Gly 
            20                  25                  30          


Ala Ala Pro Cys Pro Asp Ala Cys Cys Pro His Gly Ser Ser Gly Leu 
        35                  40                  45              


Arg Cys Thr Arg Asp Gly Ala Leu Asp Ser Leu His His Leu Pro Gly 
    50                  55                  60                  


Ala Glu Asn Leu Thr Glu Leu Tyr Ile Glu Asn Gln Gln His Leu Gln 
65                  70                  75                  80  


His Leu Glu Leu Arg Asp Leu Arg Gly Leu Gly Glu Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Lys Ser Gly Leu Arg Phe Val Ala Pro Asp Ala Phe His 
            100                 105                 110         


Phe Thr Pro Arg Leu Ser Arg Leu Asn Leu Ser Phe Asn Ala Leu Glu 
        115                 120                 125             


Ser Leu Ser Trp Lys Thr Val Gln Gly Leu Ser Leu Gln Glu Leu Val 
    130                 135                 140                 


Leu Ser Gly Asn Pro Leu His Cys Ser Cys Ala Leu Arg Trp Leu Gln 
145                 150                 155                 160 


Arg Trp Glu Glu Glu Gly Leu Gly Gly Val Pro Glu Gln Lys Leu Gln 
                165                 170                 175     


Cys His Gly Gln Gly Pro Leu Ala His Met Pro Asn Ala Ser Cys Gly 
            180                 185                 190         


Val Pro Thr Leu Lys Val Gln Val Pro Asn Ala Ser Val Asp Val Gly 
        195                 200                 205             


Asp Asp Val Leu Leu Arg Cys Gln Val Glu Gly Arg Gly Leu Glu Gln 
    210                 215                 220                 


Ala Gly Trp Ile Leu Thr Glu Leu Glu Gln Ser Ala Thr Val Met Lys 
225                 230                 235                 240 


Ser Gly Gly Leu Pro Ser Leu Gly Leu Thr Leu Ala Asn Val Thr Ser 
                245                 250                 255     


Asp Leu Asn Arg Lys Asn Val Thr Cys Trp Ala Glu Asn Asp Val Gly 
            260                 265                 270         


Arg Ala Glu Val Ser Val Gln Val Asn Val Ser Phe Pro Ala Ser Val 
        275                 280                 285             


Gln Leu His Thr Ala Val Glu Met His His Trp Cys Ile Pro Phe Ser 
    290                 295                 300                 


Val Asp Gly Gln Pro Ala Pro Ser Leu Arg Trp Leu Phe Asn Gly Ser 
305                 310                 315                 320 


Val Leu Asn Glu Thr Ser Phe Ile Phe Thr Glu Phe Leu Glu Pro Ala 
                325                 330                 335     


Ala Asn Glu Thr Val Arg His Gly Cys Leu Arg Leu Asn Gln Pro Thr 
            340                 345                 350         


His Val Asn Asn Gly Asn Tyr Thr Leu Leu Ala Ala Asn Pro Phe Gly 
        355                 360                 365             


Gln Ala Ser Ala Ser Ile Met Ala Ala Phe Met Asp Asn Pro Phe Glu 
    370                 375                 380                 


Phe Asn Pro Glu Asp Pro Ile Pro Val Ser Phe Ser Pro Val Asp Thr 
385                 390                 395                 400 


Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu Thr Pro Phe 
                405                 410                 415     


Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys Leu Phe Leu 
            420                 425                 430         


Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg Asn Lys Phe 
        435                 440                 445             


Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly Leu Ala Met 
    450                 455                 460                 


Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser Pro Thr Glu 
465                 470                 475                 480 


Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn Pro Gln Tyr 
                485                 490                 495     


Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp Ile Val Leu 
            500                 505                 510         


Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu 
        515                 520                 525             


Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val Ala Val Lys 
    530                 535                 540                 


Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe Gln Arg Glu 
545                 550                 555                 560 


Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val Arg Phe Phe 
                565                 570                 575     


Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe Glu Tyr Met 
            580                 585                 590         


Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly Pro Asp Ala 
        595                 600                 605             


Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro Leu Gly Leu 
    610                 615                 620                 


Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly Met Val Tyr 
625                 630                 635                 640 


Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys 
                645                 650                 655     


Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe Gly Met Ser 
            660                 665                 670         


Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly Arg Thr Met 
        675                 680                 685             


Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr Arg Lys Phe 
    690                 695                 700                 


Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu Trp Glu Ile 
705                 710                 715                 720 


Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn Thr Glu Ala 
                725                 730                 735     


Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro Arg Ala Cys 
            740                 745                 750         


Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln Arg Glu Pro 
        755                 760                 765             


Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu Gln Ala Leu 
    770                 775                 780                 


Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
785                 790                 795     


<210>  453
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Ser Ser Trp Ile Arg Trp His Gly Pro Ala Met Ala Arg Leu Trp 
1               5                   10                  15      


Gly Phe Cys Trp Leu Val Val Gly Phe Trp Arg Ala Ala Phe Ala Cys 
            20                  25                  30          


Pro Thr Ser Cys Lys Cys Ser Ala Ser Arg Ile Trp Cys Ser Asp Pro 
        35                  40                  45              


Ser Pro Gly Ile Val Ala Phe Pro Arg Leu Glu Pro Asn Ser Val Asp 
    50                  55                  60                  


Pro Glu Asn Ile Thr Glu Ile Phe Ile Ala Asn Gln Lys Arg Leu Glu 
65                  70                  75                  80  


Ile Ile Asn Glu Asp Asp Val Glu Ala Tyr Val Gly Leu Arg Asn Leu 
                85                  90                  95      


Thr Ile Val Asp Ser Gly Leu Lys Phe Val Ala His Lys Ala Phe Leu 
            100                 105                 110         


Lys Asn Ser Asn Leu Gln His Ile Asn Phe Thr Arg Asn Lys Leu Thr 
        115                 120                 125             


Ser Leu Ser Arg Lys His Phe Arg His Leu Asp Leu Ser Glu Leu Ile 
    130                 135                 140                 


Leu Val Gly Asn Pro Phe Thr Cys Ser Cys Asp Ile Met Trp Ile Lys 
145                 150                 155                 160 


Thr Leu Gln Glu Ala Lys Ser Ser Pro Asp Thr Gln Asp Leu Tyr Cys 
                165                 170                 175     


Leu Asn Glu Ser Ser Lys Asn Ile Pro Leu Ala Asn Leu Gln Ile Pro 
            180                 185                 190         


Asn Cys Gly Leu Pro Ser Ala Asn Leu Ala Ala Pro Asn Leu Thr Val 
        195                 200                 205             


Glu Glu Gly Lys Ser Ile Thr Leu Ser Cys Ser Val Ala Gly Asp Pro 
    210                 215                 220                 


Val Pro Asn Met Tyr Trp Asp Val Gly Asn Leu Val Ser Lys His Met 
225                 230                 235                 240 


Asn Glu Thr Ser His Thr Gln Gly Ser Leu Arg Ile Thr Asn Ile Ser 
                245                 250                 255     


Ser Asp Asp Ser Gly Lys Gln Ile Ser Cys Val Ala Glu Asn Leu Val 
            260                 265                 270         


Gly Glu Asp Gln Asp Ser Val Asn Leu Thr Val His Phe Ala Pro Thr 
        275                 280                 285             


Ile Thr Phe Leu Glu Ser Pro Thr Ser Asp His His Trp Cys Ile Pro 
    290                 295                 300                 


Phe Thr Val Lys Gly Asn Pro Lys Pro Ala Leu Gln Trp Phe Tyr Asn 
305                 310                 315                 320 


Gly Ala Ile Leu Asn Glu Ser Lys Tyr Ile Cys Thr Lys Ile His Val 
                325                 330                 335     


Thr Asn His Thr Glu Tyr His Gly Cys Leu Gln Leu Asp Asn Pro Thr 
            340                 345                 350         


His Met Asn Asn Gly Asp Tyr Thr Leu Ile Ala Lys Asn Glu Tyr Gly 
        355                 360                 365             


Lys Asp Glu Lys Gln Ile Ser Ala His Phe Met Gly Trp Pro Gly Ile 
    370                 375                 380                 


Asp Asp Gly Ala Asn Pro Asn Tyr Pro Asp Val Ile Tyr Glu Asp Tyr 
385                 390                 395                 400 


Gly Thr Ala Ala Asn Asp Ile Gly Asp Thr Thr Asn Arg Ser Asn Glu 
                405                 410                 415     


Ile Pro Ser Thr Asp Val Thr Asp Lys Thr Gly Arg Glu His Leu Ser 
            420                 425                 430         


Val Tyr Ala Val Val Val Ile Ala Ser Val Val Gly Phe Cys Leu Leu 
        435                 440                 445             


Val Met Leu Phe Leu Leu Lys Leu Ala Arg His Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Ala Ser Val Ile Ser Asn Asp Asp Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Ser Asn Gly Ser Asn Thr Pro Ser Ser Ser Glu Gly 
                485                 490                 495     


Gly Pro Asp Ala Val Ile Ile Gly Met Thr Lys Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Gly Ile Thr Asn Ser Gln Leu Lys Pro Asp Thr 
        515                 520                 525             


Phe Val Gln His Ile Lys Arg His Asn Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Cys Pro Glu Gln Asp Lys Ile Leu Val Ala Val Lys Thr Leu Lys Asp 
                565                 570                 575     


Ala Ser Asp Asn Ala Arg Lys Asp Phe His Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Val 
        595                 600                 605             


Glu Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Val Leu Met Ala 
625                 630                 635                 640 


Glu Gly Asn Pro Pro Thr Glu Leu Thr Gln Ser Gln Met Leu His Ile 
                645                 650                 655     


Ala Gln Gln Ile Ala Ala Gly Met Val Tyr Leu Ala Ser Gln His Phe 
            660                 665                 670         


Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Glu Asn Leu 
        675                 680                 685             


Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val Tyr Ser Thr 
    690                 695                 700                 


Asp Tyr Tyr Arg Val Gly Gly His Thr Met Leu Pro Ile Arg Trp Met 
705                 710                 715                 720 


Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp Val 
                725                 730                 735     


Trp Ser Leu Gly Val Val Leu Trp Glu Ile Phe Thr Tyr Gly Lys Gln 
            740                 745                 750         


Pro Trp Tyr Gln Leu Ser Asn Asn Glu Val Ile Glu Cys Ile Thr Gln 
        755                 760                 765             


Gly Arg Val Leu Gln Arg Pro Arg Thr Cys Pro Gln Glu Val Tyr Glu 
    770                 775                 780                 


Leu Met Leu Gly Cys Trp Gln Arg Glu Pro His Met Arg Lys Asn Ile 
785                 790                 795                 800 


Lys Gly Ile His Thr Leu Leu Gln Asn Leu Ala Lys Ala Ser Pro Val 
                805                 810                 815     


Tyr Leu Asp Ile Leu Gly 
            820         


<210>  454
<211>  839
<212>  PRT
<213>  Homo sapiens

<400>  454

Met Asp Val Ser Leu Cys Pro Ala Lys Cys Ser Phe Trp Arg Ile Phe 
1               5                   10                  15      


Leu Leu Gly Ser Val Trp Leu Asp Tyr Val Gly Ser Val Leu Ala Cys 
            20                  25                  30          


Pro Ala Asn Cys Val Cys Ser Lys Thr Glu Ile Asn Cys Arg Arg Pro 
        35                  40                  45              


Asp Asp Gly Asn Leu Phe Pro Leu Leu Glu Gly Gln Asp Ser Gly Asn 
    50                  55                  60                  


Ser Asn Gly Asn Ala Ser Ile Asn Ile Thr Asp Ile Ser Arg Asn Ile 
65                  70                  75                  80  


Thr Ser Ile His Ile Glu Asn Trp Arg Ser Leu His Thr Leu Asn Ala 
                85                  90                  95      


Val Asp Met Glu Leu Tyr Thr Gly Leu Gln Lys Leu Thr Ile Lys Asn 
            100                 105                 110         


Ser Gly Leu Arg Ser Ile Gln Pro Arg Ala Phe Ala Lys Asn Pro His 
        115                 120                 125             


Leu Arg Tyr Ile Asn Leu Ser Ser Asn Arg Leu Thr Thr Leu Ser Trp 
    130                 135                 140                 


Gln Leu Phe Gln Thr Leu Ser Leu Arg Glu Leu Gln Leu Glu Gln Asn 
145                 150                 155                 160 


Phe Phe Asn Cys Ser Cys Asp Ile Arg Trp Met Gln Leu Trp Gln Glu 
                165                 170                 175     


Gln Gly Glu Ala Lys Leu Asn Ser Gln Asn Leu Tyr Cys Ile Asn Ala 
            180                 185                 190         


Asp Gly Ser Gln Leu Pro Leu Phe Arg Met Asn Ile Ser Gln Cys Asp 
        195                 200                 205             


Leu Pro Glu Ile Ser Val Ser His Val Asn Leu Thr Val Arg Glu Gly 
    210                 215                 220                 


Asp Asn Ala Val Ile Thr Cys Asn Gly Ser Gly Ser Pro Leu Pro Asp 
225                 230                 235                 240 


Val Asp Trp Ile Val Thr Gly Leu Gln Ser Ile Asn Thr His Gln Thr 
                245                 250                 255     


Asn Leu Asn Trp Thr Asn Val His Ala Ile Asn Leu Thr Leu Val Asn 
            260                 265                 270         


Val Thr Ser Glu Asp Asn Gly Phe Thr Leu Thr Cys Ile Ala Glu Asn 
        275                 280                 285             


Val Val Gly Met Ser Asn Ala Ser Val Ala Leu Thr Val Tyr Tyr Pro 
    290                 295                 300                 


Pro Arg Val Val Ser Leu Glu Glu Pro Glu Leu Arg Leu Glu His Cys 
305                 310                 315                 320 


Ile Glu Phe Val Val Arg Gly Asn Pro Pro Pro Thr Leu His Trp Leu 
                325                 330                 335     


His Asn Gly Gln Pro Leu Arg Glu Ser Lys Ile Ile His Val Glu Tyr 
            340                 345                 350         


Tyr Gln Glu Gly Glu Ile Ser Glu Gly Cys Leu Leu Phe Asn Lys Pro 
        355                 360                 365             


Thr His Tyr Asn Asn Gly Asn Tyr Thr Leu Ile Ala Lys Asn Pro Leu 
    370                 375                 380                 


Gly Thr Ala Asn Gln Thr Ile Asn Gly His Phe Leu Lys Glu Pro Phe 
385                 390                 395                 400 


Pro Glu Ser Thr Asp Asn Phe Ile Leu Phe Asp Glu Val Ser Pro Thr 
                405                 410                 415     


Pro Pro Ile Thr Val Thr His Lys Pro Glu Glu Asp Thr Phe Gly Val 
            420                 425                 430         


Ser Ile Ala Val Gly Leu Ala Ala Phe Ala Cys Val Leu Leu Val Val 
        435                 440                 445             


Leu Phe Val Met Ile Asn Lys Tyr Gly Arg Arg Ser Lys Phe Gly Met 
    450                 455                 460                 


Lys Gly Pro Val Ala Val Ile Ser Gly Glu Glu Asp Ser Ala Ser Pro 
465                 470                 475                 480 


Leu His His Ile Asn His Gly Ile Thr Thr Pro Ser Ser Leu Asp Ala 
                485                 490                 495     


Gly Pro Asp Thr Val Val Ile Gly Met Thr Arg Ile Pro Val Ile Glu 
            500                 505                 510         


Asn Pro Gln Tyr Phe Arg Gln Gly His Asn Cys His Lys Pro Asp Thr 
        515                 520                 525             


Tyr Val Gln His Ile Lys Arg Arg Asp Ile Val Leu Lys Arg Glu Leu 
    530                 535                 540                 


Gly Glu Gly Ala Phe Gly Lys Val Phe Leu Ala Glu Cys Tyr Asn Leu 
545                 550                 555                 560 


Ser Pro Thr Lys Asp Lys Met Leu Val Ala Val Lys Ala Leu Lys Asp 
                565                 570                 575     


Pro Thr Leu Ala Ala Arg Lys Asp Phe Gln Arg Glu Ala Glu Leu Leu 
            580                 585                 590         


Thr Asn Leu Gln His Glu His Ile Val Lys Phe Tyr Gly Val Cys Gly 
        595                 600                 605             


Asp Gly Asp Pro Leu Ile Met Val Phe Glu Tyr Met Lys His Gly Asp 
    610                 615                 620                 


Leu Asn Lys Phe Leu Arg Ala His Gly Pro Asp Ala Met Ile Leu Val 
625                 630                 635                 640 


Asp Gly Gln Pro Arg Gln Ala Lys Gly Glu Leu Gly Leu Ser Gln Met 
                645                 650                 655     


Leu His Ile Ala Ser Gln Ile Ala Ser Gly Met Val Tyr Leu Ala Ser 
            660                 665                 670         


Gln His Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly 
        675                 680                 685             


Ala Asn Leu Leu Val Lys Ile Gly Asp Phe Gly Met Ser Arg Asp Val 
    690                 695                 700                 


Tyr Ser Thr Asp Tyr Tyr Arg Leu Phe Asn Pro Ser Gly Asn Asp Phe 
705                 710                 715                 720 


Cys Ile Trp Cys Glu Val Gly Gly His Thr Met Leu Pro Ile Arg Trp 
                725                 730                 735     


Met Pro Pro Glu Ser Ile Met Tyr Arg Lys Phe Thr Thr Glu Ser Asp 
            740                 745                 750         


Val Trp Ser Phe Gly Val Ile Leu Trp Glu Ile Phe Thr Tyr Gly Lys 
        755                 760                 765             


Gln Pro Trp Phe Gln Leu Ser Asn Thr Glu Val Ile Glu Cys Ile Thr 
    770                 775                 780                 


Gln Gly Arg Val Leu Glu Arg Pro Arg Val Cys Pro Lys Glu Val Tyr 
785                 790                 795                 800 


Asp Val Met Leu Gly Cys Trp Gln Arg Glu Pro Gln Gln Arg Leu Asn 
                805                 810                 815     


Ile Lys Glu Ile Tyr Lys Ile Leu His Ala Leu Gly Lys Ala Thr Pro 
            820                 825                 830         


Ile Tyr Leu Asp Ile Leu Gly 
        835                 


<210>  455
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  455

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  456
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  456

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Thr Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Val Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  457
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  457

Met Ile Leu Ile Pro Arg Met Leu Leu Val Leu Phe Leu Leu Leu Pro 
1               5                   10                  15      


Ile Leu Ser Ser Ala Lys Ala Gln Val Asn Pro Ala Ile Cys Arg Tyr 
            20                  25                  30          


Pro Leu Gly Met Ser Gly Gly Gln Ile Pro Asp Glu Asp Ile Thr Ala 
        35                  40                  45              


Ser Ser Gln Trp Ser Glu Ser Thr Ala Ala Lys Tyr Gly Arg Leu Asp 
    50                  55                  60                  


Ser Glu Glu Gly Asp Gly Ala Trp Cys Pro Glu Ile Pro Val Glu Pro 
65                  70                  75                  80  


Asp Asp Leu Lys Glu Phe Leu Gln Ile Asp Leu His Thr Leu His Phe 
                85                  90                  95      


Ile Thr Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly His Gly Ile 
            100                 105                 110         


Glu Phe Ala Pro Met Tyr Lys Ile Asn Tyr Ser Arg Asp Gly Thr Arg 
        115                 120                 125             


Trp Ile Ser Trp Arg Asn Arg His Gly Lys Gln Val Leu Asp Gly Asn 
    130                 135                 140                 


Ser Asn Pro Tyr Asp Ile Phe Leu Lys Asp Leu Glu Pro Pro Ile Val 
145                 150                 155                 160 


Ala Arg Phe Val Arg Phe Ile Pro Val Thr Asp His Ser Met Asn Val 
                165                 170                 175     


Cys Met Arg Val Glu Leu Tyr Gly Cys Val Trp Leu Asp Gly Leu Val 
            180                 185                 190         


Ser Tyr Asn Ala Pro Ala Gly Gln Gln Phe Val Leu Pro Gly Gly Ser 
        195                 200                 205             


Ile Ile Tyr Leu Asn Asp Ser Val Tyr Asp Gly Ala Val Gly Tyr Ser 
    210                 215                 220                 


Met Thr Glu Gly Leu Gly Gln Leu Thr Asp Gly Val Ser Gly Leu Asp 
225                 230                 235                 240 


Asp Phe Thr Gln Thr His Glu Tyr His Val Trp Pro Gly Tyr Asp Tyr 
                245                 250                 255     


Val Gly Trp Arg Asn Glu Ser Ala Thr Asn Gly Tyr Ile Glu Ile Met 
            260                 265                 270         


Phe Glu Phe Asp Arg Ile Arg Asn Phe Thr Thr Met Lys Val His Cys 
        275                 280                 285             


Asn Asn Met Phe Ala Lys Gly Val Lys Ile Phe Lys Glu Val Gln Cys 
    290                 295                 300                 


Tyr Phe Arg Ser Glu Ala Ser Glu Trp Glu Pro Asn Ala Ile Ser Phe 
305                 310                 315                 320 


Pro Leu Val Leu Asp Asp Val Asn Pro Ser Ala Arg Phe Val Thr Val 
                325                 330                 335     


Pro Leu His His Arg Met Ala Ser Ala Ile Lys Cys Gln Tyr His Phe 
            340                 345                 350         


Ala Asp Thr Trp Met Met Phe Ser Glu Ile Thr Phe Gln Ser Asp Ala 
        355                 360                 365             


Ala Met Tyr Asn Asn Ser Glu Ala Leu Pro Thr Ser Pro Met Ala Pro 
    370                 375                 380                 


Thr Thr Tyr Asp Pro Met Leu Lys Val Asp Asp Ser Asn Thr Arg Ile 
385                 390                 395                 400 


Leu Ile Gly Cys Leu Val Ala Ile Ile Phe Ile Leu Leu Ala Ile Ile 
                405                 410                 415     


Val Ile Ile Leu Trp Arg Gln Phe Trp Gln Lys Met Leu Glu Lys Ala 
            420                 425                 430         


Ser Arg Arg Met Leu Asp Asp Glu Met Thr Val Ser Leu Ser Leu Pro 
        435                 440                 445             


Ser Asp Ser Ser Met Phe Asn Asn Asn Arg Ser Ser Ser Pro Ser Glu 
    450                 455                 460                 


Gln Gly Ser Asn Ser Thr Tyr Asp Arg Ile Phe Pro Leu Arg Pro Asp 
465                 470                 475                 480 


Tyr Gln Glu Pro Ser Arg Leu Ile Arg Lys Leu Pro Glu Phe Ala Pro 
                485                 490                 495     


Gly Glu Glu Glu Ser Gly Cys Ser Gly Val Val Lys Pro Val Gln Pro 
            500                 505                 510         


Ser Gly Pro Glu Gly Val Pro His Tyr Ala Glu Ala Asp Ile Val Asn 
        515                 520                 525             


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ser Val Pro Ala Val Thr 
    530                 535                 540                 


Met Asp Leu Leu Ser Gly Lys Asp Val Ala Val Glu Glu Phe Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Thr Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu 
                565                 570                 575     


Val His Leu Cys Glu Val Glu Gly Met Glu Lys Phe Lys Asp Lys Asp 
            580                 585                 590         


Phe Ala Leu Asp Val Ser Ala Asn Gln Pro Val Leu Val Ala Val Lys 
        595                 600                 605             


Met Leu Arg Ala Asp Ala Asn Lys Asn Ala Arg Asn Asp Phe Leu Lys 
    610                 615                 620                 


Glu Ile Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile His Leu 
625                 630                 635                 640 


Leu Ala Val Cys Ile Thr Asp Asp Pro Leu Cys Met Ile Thr Glu Tyr 
                645                 650                 655     


Met Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Arg His Glu Pro Pro 
            660                 665                 670         


Asn Ser Ser Ser Ser Asp Val Arg Thr Val Ser Tyr Thr Asn Leu Lys 
        675                 680                 685             


Phe Met Ala Thr Gln Ile Ala Ser Gly Met Lys Tyr Leu Ser Ser Leu 
    690                 695                 700                 


Asn Phe Val His Arg Asp Leu Ala Thr Arg Asn Cys Leu Val Gly Lys 
705                 710                 715                 720 


Asn Tyr Thr Ile Lys Ile Ala Asp Phe Gly Met Ser Arg Asn Leu Tyr 
                725                 730                 735     


Ser Gly Asp Tyr Tyr Arg Ile Gln Gly Arg Ala Val Leu Pro Ile Arg 
            740                 745                 750         


Trp Met Ser Trp Glu Ser Ile Leu Leu Gly Lys Phe Thr Thr Ala Ser 
        755                 760                 765             


Asp Val Trp Ala Phe Gly Val Thr Leu Trp Glu Thr Phe Thr Phe Cys 
    770                 775                 780                 


Gln Glu Gln Pro Tyr Ser Gln Leu Ser Asp Glu Gln Val Ile Glu Asn 
785                 790                 795                 800 


Thr Gly Glu Phe Phe Arg Asp Gln Gly Arg Gln Thr Tyr Leu Pro Gln 
                805                 810                 815     


Pro Ala Ile Cys Pro Asp Ser Val Tyr Lys Leu Met Leu Ser Cys Trp 
            820                 825                 830         


Arg Arg Asp Thr Lys Asn Arg Pro Ser Phe Gln Glu Ile His Leu Leu 
        835                 840                 845             


Leu Leu Gln Gln Gly Asp Glu 
    850                 855 


<210>  458
<211>  1089
<212>  PRT
<213>  Homo sapiens

<400>  458

Met Gly Thr Ser His Pro Ala Phe Leu Val Leu Gly Cys Leu Leu Thr 
1               5                   10                  15      


Gly Leu Ser Leu Ile Leu Cys Gln Leu Ser Leu Pro Ser Ile Leu Pro 
            20                  25                  30          


Asn Glu Asn Glu Lys Val Val Gln Leu Asn Ser Ser Phe Ser Leu Arg 
        35                  40                  45              


Cys Phe Gly Glu Ser Glu Val Ser Trp Gln Tyr Pro Met Ser Glu Glu 
    50                  55                  60                  


Glu Ser Ser Asp Val Glu Ile Arg Asn Glu Glu Asn Asn Ser Gly Leu 
65                  70                  75                  80  


Phe Val Thr Val Leu Glu Val Ser Ser Ala Ser Ala Ala His Thr Gly 
                85                  90                  95      


Leu Tyr Thr Cys Tyr Tyr Asn His Thr Gln Thr Glu Glu Asn Glu Leu 
            100                 105                 110         


Glu Gly Arg His Ile Tyr Ile Tyr Val Pro Asp Pro Asp Val Ala Phe 
        115                 120                 125             


Val Pro Leu Gly Met Thr Asp Tyr Leu Val Ile Val Glu Asp Asp Asp 
    130                 135                 140                 


Ser Ala Ile Ile Pro Cys Arg Thr Thr Asp Pro Glu Thr Pro Val Thr 
145                 150                 155                 160 


Leu His Asn Ser Glu Gly Val Val Pro Ala Ser Tyr Asp Ser Arg Gln 
                165                 170                 175     


Gly Phe Asn Gly Thr Phe Thr Val Gly Pro Tyr Ile Cys Glu Ala Thr 
            180                 185                 190         


Val Lys Gly Lys Lys Phe Gln Thr Ile Pro Phe Asn Val Tyr Ala Leu 
        195                 200                 205             


Lys Ala Thr Ser Glu Leu Asp Leu Glu Met Glu Ala Leu Lys Thr Val 
    210                 215                 220                 


Tyr Lys Ser Gly Glu Thr Ile Val Val Thr Cys Ala Val Phe Asn Asn 
225                 230                 235                 240 


Glu Val Val Asp Leu Gln Trp Thr Tyr Pro Gly Glu Val Lys Gly Lys 
                245                 250                 255     


Gly Ile Thr Met Leu Glu Glu Ile Lys Val Pro Ser Ile Lys Leu Val 
            260                 265                 270         


Tyr Thr Leu Thr Val Pro Glu Ala Thr Val Lys Asp Ser Gly Asp Tyr 
        275                 280                 285             


Glu Cys Ala Ala Arg Gln Ala Thr Arg Glu Val Lys Glu Met Lys Lys 
    290                 295                 300                 


Val Thr Ile Ser Val His Glu Lys Gly Phe Ile Glu Ile Lys Pro Thr 
305                 310                 315                 320 


Phe Ser Gln Leu Glu Ala Val Asn Leu His Glu Val Lys His Phe Val 
                325                 330                 335     


Val Glu Val Arg Ala Tyr Pro Pro Pro Arg Ile Ser Trp Leu Lys Asn 
            340                 345                 350         


Asn Leu Thr Leu Ile Glu Asn Leu Thr Glu Ile Thr Thr Asp Val Glu 
        355                 360                 365             


Lys Ile Gln Glu Ile Arg Tyr Arg Ser Lys Leu Lys Leu Ile Arg Ala 
    370                 375                 380                 


Lys Glu Glu Asp Ser Gly His Tyr Thr Ile Val Ala Gln Asn Glu Asp 
385                 390                 395                 400 


Ala Val Lys Ser Tyr Thr Phe Glu Leu Leu Thr Gln Val Pro Ser Ser 
                405                 410                 415     


Ile Leu Asp Leu Val Asp Asp His His Gly Ser Thr Gly Gly Gln Thr 
            420                 425                 430         


Val Arg Cys Thr Ala Glu Gly Thr Pro Leu Pro Asp Ile Glu Trp Met 
        435                 440                 445             


Ile Cys Lys Asp Ile Lys Lys Cys Asn Asn Glu Thr Ser Trp Thr Ile 
    450                 455                 460                 


Leu Ala Asn Asn Val Ser Asn Ile Ile Thr Glu Ile His Ser Arg Asp 
465                 470                 475                 480 


Arg Ser Thr Val Glu Gly Arg Val Thr Phe Ala Lys Val Glu Glu Thr 
                485                 490                 495     


Ile Ala Val Arg Cys Leu Ala Lys Asn Leu Leu Gly Ala Glu Asn Arg 
            500                 505                 510         


Glu Leu Lys Leu Val Ala Pro Thr Leu Arg Ser Glu Leu Thr Val Ala 
        515                 520                 525             


Ala Ala Val Leu Val Leu Leu Val Ile Val Ile Ile Ser Leu Ile Val 
    530                 535                 540                 


Leu Val Val Ile Trp Lys Gln Lys Pro Arg Tyr Glu Ile Arg Trp Arg 
545                 550                 555                 560 


Val Ile Glu Ser Ile Ser Pro Asp Gly His Glu Tyr Ile Tyr Val Asp 
                565                 570                 575     


Pro Met Gln Leu Pro Tyr Asp Ser Arg Trp Glu Phe Pro Arg Asp Gly 
            580                 585                 590         


Leu Val Leu Gly Arg Val Leu Gly Ser Gly Ala Phe Gly Lys Val Val 
        595                 600                 605             


Glu Gly Thr Ala Tyr Gly Leu Ser Arg Ser Gln Pro Val Met Lys Val 
    610                 615                 620                 


Ala Val Lys Met Leu Lys Pro Thr Ala Arg Ser Ser Glu Lys Gln Ala 
625                 630                 635                 640 


Leu Met Ser Glu Leu Lys Ile Met Thr His Leu Gly Pro His Leu Asn 
                645                 650                 655     


Ile Val Asn Leu Leu Gly Ala Cys Thr Lys Ser Gly Pro Ile Tyr Ile 
            660                 665                 670         


Ile Thr Glu Tyr Cys Phe Tyr Gly Asp Leu Val Asn Tyr Leu His Lys 
        675                 680                 685             


Asn Arg Asp Ser Phe Leu Ser His His Pro Glu Lys Pro Lys Lys Glu 
    690                 695                 700                 


Leu Asp Ile Phe Gly Leu Asn Pro Ala Asp Glu Ser Thr Arg Ser Tyr 
705                 710                 715                 720 


Val Ile Leu Ser Phe Glu Asn Asn Gly Asp Tyr Met Asp Met Lys Gln 
                725                 730                 735     


Ala Asp Thr Thr Gln Tyr Val Pro Met Leu Glu Arg Lys Glu Val Ser 
            740                 745                 750         


Lys Tyr Ser Asp Ile Gln Arg Ser Leu Tyr Asp Arg Pro Ala Ser Tyr 
        755                 760                 765             


Lys Lys Lys Ser Met Leu Asp Ser Glu Val Lys Asn Leu Leu Ser Asp 
    770                 775                 780                 


Asp Asn Ser Glu Gly Leu Thr Leu Leu Asp Leu Leu Ser Phe Thr Tyr 
785                 790                 795                 800 


Gln Val Ala Arg Gly Met Glu Phe Leu Ala Ser Lys Asn Cys Val His 
                805                 810                 815     


Arg Asp Leu Ala Ala Arg Asn Val Leu Leu Ala Gln Gly Lys Ile Val 
            820                 825                 830         


Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Met His Asp Ser Asn 
        835                 840                 845             


Tyr Val Ser Lys Gly Ser Thr Phe Leu Pro Val Lys Trp Met Ala Pro 
    850                 855                 860                 


Glu Ser Ile Phe Asp Asn Leu Tyr Thr Thr Leu Ser Asp Val Trp Ser 
865                 870                 875                 880 


Tyr Gly Ile Leu Leu Trp Glu Ile Phe Ser Leu Gly Gly Thr Pro Tyr 
                885                 890                 895     


Pro Gly Met Met Val Asp Ser Thr Phe Tyr Asn Lys Ile Lys Ser Gly 
            900                 905                 910         


Tyr Arg Met Ala Lys Pro Asp His Ala Thr Ser Glu Val Tyr Glu Ile 
        915                 920                 925             


Met Val Lys Cys Trp Asn Ser Glu Pro Glu Lys Arg Pro Ser Phe Tyr 
    930                 935                 940                 


His Leu Ser Glu Ile Val Glu Asn Leu Leu Pro Gly Gln Tyr Lys Lys 
945                 950                 955                 960 


Ser Tyr Glu Lys Ile His Leu Asp Phe Leu Lys Ser Asp His Pro Ala 
                965                 970                 975     


Val Ala Arg Met Arg Val Asp Ser Asp Asn Ala Tyr Ile Gly Val Thr 
            980                 985                 990         


Tyr Lys Asn Glu Glu Asp Lys Leu  Lys Asp Trp Glu Gly  Gly Leu Asp 
        995                 1000                 1005             


Glu Gln  Arg Leu Ser Ala Asp  Ser Gly Tyr Ile Ile  Pro Leu Pro 
    1010                 1015                 1020             


Asp Ile  Asp Pro Val Pro Glu  Glu Glu Asp Leu Gly  Lys Arg Asn 
    1025                 1030                 1035             


Arg His  Ser Ser Gln Thr Ser  Glu Glu Ser Ala Ile  Glu Thr Gly 
    1040                 1045                 1050             


Ser Ser  Ser Ser Thr Phe Ile  Lys Arg Glu Asp Glu  Thr Ile Glu 
    1055                 1060                 1065             


Asp Ile  Asp Met Met Asp Asp  Ile Gly Ile Asp Ser  Ser Asp Leu 
    1070                 1075                 1080             


Val Glu  Asp Ser Phe Leu 
    1085                 


<210>  459
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  459

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  460
<211>  894
<212>  PRT
<213>  Homo sapiens

<400>  460

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  461
<211>  1070
<212>  PRT
<213>  Homo sapiens

<400>  461

Met Gly Ala Ala Arg Gly Ser Pro Ala Arg Pro Arg Arg Leu Pro Leu 
1               5                   10                  15      


Leu Ser Val Leu Leu Leu Pro Leu Leu Gly Gly Thr Gln Thr Ala Ile 
            20                  25                  30          


Val Phe Ile Lys Gln Pro Ser Ser Gln Asp Ala Leu Gln Gly Arg Arg 
        35                  40                  45              


Ala Leu Leu Arg Cys Glu Val Glu Ala Pro Gly Pro Val His Val Tyr 
    50                  55                  60                  


Trp Leu Leu Asp Gly Ala Pro Val Gln Asp Thr Glu Arg Arg Phe Ala 
65                  70                  75                  80  


Gln Gly Ser Ser Leu Ser Phe Ala Ala Val Asp Arg Leu Gln Asp Ser 
                85                  90                  95      


Gly Thr Phe Gln Cys Val Ala Arg Asp Asp Val Thr Gly Glu Glu Ala 
            100                 105                 110         


Arg Ser Ala Asn Ala Ser Phe Asn Ile Lys Trp Ile Glu Ala Gly Pro 
        115                 120                 125             


Val Val Leu Lys His Pro Ala Ser Glu Ala Glu Ile Gln Pro Gln Thr 
    130                 135                 140                 


Gln Val Thr Leu Arg Cys His Ile Asp Gly His Pro Arg Pro Thr Tyr 
145                 150                 155                 160 


Gln Trp Phe Arg Asp Gly Thr Pro Leu Ser Asp Gly Gln Ser Asn His 
                165                 170                 175     


Thr Val Ser Ser Lys Glu Arg Asn Leu Thr Leu Arg Pro Ala Gly Pro 
            180                 185                 190         


Glu His Ser Gly Leu Tyr Ser Cys Cys Ala His Ser Ala Phe Gly Gln 
        195                 200                 205             


Ala Cys Ser Ser Gln Asn Phe Thr Leu Ser Ile Ala Asp Glu Ser Phe 
    210                 215                 220                 


Ala Arg Val Val Leu Ala Pro Gln Asp Val Val Val Ala Arg Tyr Glu 
225                 230                 235                 240 


Glu Ala Met Phe His Cys Gln Phe Ser Ala Gln Pro Pro Pro Ser Leu 
                245                 250                 255     


Gln Trp Leu Phe Glu Asp Glu Thr Pro Ile Thr Asn Arg Ser Arg Pro 
            260                 265                 270         


Pro His Leu Arg Arg Ala Thr Val Phe Ala Asn Gly Ser Leu Leu Leu 
        275                 280                 285             


Thr Gln Val Arg Pro Arg Asn Ala Gly Ile Tyr Arg Cys Ile Gly Gln 
    290                 295                 300                 


Gly Gln Arg Gly Pro Pro Ile Ile Leu Glu Ala Thr Leu His Leu Ala 
305                 310                 315                 320 


Glu Ile Glu Asp Met Pro Leu Phe Glu Pro Arg Val Phe Thr Ala Gly 
                325                 330                 335     


Ser Glu Glu Arg Val Thr Cys Leu Pro Pro Lys Gly Leu Pro Glu Pro 
            340                 345                 350         


Ser Val Trp Trp Glu His Ala Gly Val Arg Leu Pro Thr His Gly Arg 
        355                 360                 365             


Val Tyr Gln Lys Gly His Glu Leu Val Leu Ala Asn Ile Ala Glu Ser 
    370                 375                 380                 


Asp Ala Gly Val Tyr Thr Cys His Ala Ala Asn Leu Ala Gly Gln Arg 
385                 390                 395                 400 


Arg Gln Asp Val Asn Ile Thr Val Ala Thr Val Pro Ser Trp Leu Lys 
                405                 410                 415     


Lys Pro Gln Asp Ser Gln Leu Glu Glu Gly Lys Pro Gly Tyr Leu Asp 
            420                 425                 430         


Cys Leu Thr Gln Ala Thr Pro Lys Pro Thr Val Val Trp Tyr Arg Asn 
        435                 440                 445             


Gln Met Leu Ile Ser Glu Asp Ser Arg Phe Glu Val Phe Lys Asn Gly 
    450                 455                 460                 


Thr Leu Arg Ile Asn Ser Val Glu Val Tyr Asp Gly Thr Trp Tyr Arg 
465                 470                 475                 480 


Cys Met Ser Ser Thr Pro Ala Gly Ser Ile Glu Ala Gln Ala Arg Val 
                485                 490                 495     


Gln Val Leu Glu Lys Leu Lys Phe Thr Pro Pro Pro Gln Pro Gln Gln 
            500                 505                 510         


Cys Met Glu Phe Asp Lys Glu Ala Thr Val Pro Cys Ser Ala Thr Gly 
        515                 520                 525             


Arg Glu Lys Pro Thr Ile Lys Trp Glu Arg Ala Asp Gly Ser Ser Leu 
    530                 535                 540                 


Pro Glu Trp Val Thr Asp Asn Ala Gly Thr Leu His Phe Ala Arg Val 
545                 550                 555                 560 


Thr Arg Asp Asp Ala Gly Asn Tyr Thr Cys Ile Ala Ser Asn Gly Pro 
                565                 570                 575     


Gln Gly Gln Ile Arg Ala His Val Gln Leu Thr Val Ala Val Phe Ile 
            580                 585                 590         


Thr Phe Lys Val Glu Pro Glu Arg Thr Thr Val Tyr Gln Gly His Thr 
        595                 600                 605             


Ala Leu Leu Gln Cys Glu Ala Gln Gly Asp Pro Lys Pro Leu Ile Gln 
    610                 615                 620                 


Trp Lys Gly Lys Asp Arg Ile Leu Asp Pro Thr Lys Leu Gly Pro Arg 
625                 630                 635                 640 


Met His Ile Phe Gln Asn Gly Ser Leu Val Ile His Asp Val Ala Pro 
                645                 650                 655     


Glu Asp Ser Gly Arg Tyr Thr Cys Ile Ala Gly Asn Ser Cys Asn Ile 
            660                 665                 670         


Lys His Thr Glu Ala Pro Leu Tyr Val Val Asp Lys Pro Val Pro Glu 
        675                 680                 685             


Glu Ser Glu Gly Pro Gly Ser Pro Pro Pro Tyr Lys Met Ile Gln Thr 
    690                 695                 700                 


Ile Gly Leu Ser Val Gly Ala Ala Val Ala Tyr Ile Ile Ala Val Leu 
705                 710                 715                 720 


Gly Leu Met Phe Tyr Cys Lys Lys Arg Cys Lys Ala Lys Arg Leu Gln 
                725                 730                 735     


Lys Gln Pro Glu Gly Glu Glu Pro Glu Met Glu Cys Leu Asn Gly Gly 
            740                 745                 750         


Pro Leu Gln Asn Gly Gln Pro Ser Ala Glu Ile Gln Glu Glu Val Ala 
        755                 760                 765             


Leu Thr Ser Leu Gly Ser Gly Pro Ala Ala Thr Asn Lys Arg His Ser 
    770                 775                 780                 


Thr Ser Asp Lys Met His Phe Pro Arg Ser Ser Leu Gln Pro Ile Thr 
785                 790                 795                 800 


Thr Leu Gly Lys Ser Glu Phe Gly Glu Val Phe Leu Ala Lys Ala Gln 
                805                 810                 815     


Gly Leu Glu Glu Gly Val Ala Glu Thr Leu Val Leu Val Lys Ser Leu 
            820                 825                 830         


Gln Ser Lys Asp Glu Gln Gln Gln Leu Asp Phe Arg Arg Glu Leu Glu 
        835                 840                 845             


Met Phe Gly Lys Leu Asn His Ala Asn Val Val Arg Leu Leu Gly Leu 
    850                 855                 860                 


Cys Arg Glu Ala Glu Pro His Tyr Met Val Leu Glu Tyr Val Asp Leu 
865                 870                 875                 880 


Gly Asp Leu Lys Gln Phe Leu Arg Ile Ser Lys Ser Lys Asp Glu Lys 
                885                 890                 895     


Leu Lys Ser Gln Pro Leu Ser Thr Lys Gln Lys Val Ala Leu Cys Thr 
            900                 905                 910         


Gln Val Ala Leu Gly Met Glu His Leu Ser Asn Asn Arg Phe Val His 
        915                 920                 925             


Lys Asp Leu Ala Ala Arg Asn Cys Leu Val Ser Ala Gln Arg Gln Val 
    930                 935                 940                 


Lys Val Ser Ala Leu Gly Leu Ser Lys Asp Val Tyr Asn Ser Glu Tyr 
945                 950                 955                 960 


Tyr His Phe Arg Gln Ala Trp Val Pro Leu Arg Trp Met Ser Pro Glu 
                965                 970                 975     


Ala Ile Leu Glu Gly Asp Phe Ser Thr Lys Ser Asp Val Trp Ala Phe 
            980                 985                 990         


Gly Val Leu Met Trp Glu Val Phe  Thr His Gly Glu Met  Pro His Gly 
        995                 1000                 1005             


Gly Gln  Ala Asp Asp Glu Val  Leu Ala Asp Leu Gln  Ala Gly Lys 
    1010                 1015                 1020             


Ala Arg  Leu Pro Gln Pro Glu  Gly Cys Pro Ser Lys  Leu Tyr Arg 
    1025                 1030                 1035             


Leu Met  Gln Arg Cys Trp Ala  Leu Ser Pro Lys Asp  Arg Pro Ser 
    1040                 1045                 1050             


Phe Ser  Glu Ile Ala Ser Ala  Leu Gly Asp Ser Thr  Val Asp Ser 
    1055                 1060                 1065             


Lys Pro  
    1070 


<210>  462
<211>  1114
<212>  PRT
<213>  Homo sapiens

<400>  462

Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser 
            20                  25                  30          


Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr 
        35                  40                  45              


Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro 
    50                  55                  60                  


Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu 
65                  70                  75                  80  


His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr 
                85                  90                  95      


Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg 
            100                 105                 110         


Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser 
        115                 120                 125             


Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg 
    130                 135                 140                 


Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu 
145                 150                 155                 160 


Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile 
                165                 170                 175     


Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro 
            180                 185                 190         


Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu 
        195                 200                 205             


Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser 
    210                 215                 220                 


Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val 
225                 230                 235                 240 


Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val 
                245                 250                 255     


Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe 
            260                 265                 270         


Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys 
        275                 280                 285             


Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val 
    290                 295                 300                 


Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro 
305                 310                 315                 320 


Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn 
                325                 330                 335     


Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His 
            340                 345                 350         


Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg 
        355                 360                 365             


Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro 
    370                 375                 380                 


Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val 
385                 390                 395                 400 


Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala 
                405                 410                 415     


Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala 
            420                 425                 430         


Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn 
        435                 440                 445             


Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile 
    450                 455                 460                 


Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu 
465                 470                 475                 480 


Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala 
                485                 490                 495     


Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu 
            500                 505                 510         


Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys 
        515                 520                 525             


Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg 
    530                 535                 540                 


Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro 
545                 550                 555                 560 


Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln 
                565                 570                 575     


Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly 
            580                 585                 590         


Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr 
        595                 600                 605             


Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp 
    610                 615                 620                 


Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala 
625                 630                 635                 640 


Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys 
                645                 650                 655     


Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala 
            660                 665                 670         


Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser 
        675                 680                 685             


Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val 
    690                 695                 700                 


Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro 
705                 710                 715                 720 


Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly 
                725                 730                 735     


Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr 
            740                 745                 750         


Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu 
        755                 760                 765             


Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His 
    770                 775                 780                 


Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu 
785                 790                 795                 800 


Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu 
                805                 810                 815     


Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser 
            820                 825                 830         


Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met 
        835                 840                 845             


Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr 
    850                 855                 860                 


Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile 
865                 870                 875                 880 


Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser 
                885                 890                 895     


Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg 
            900                 905                 910         


Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr 
        915                 920                 925             


Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile 
    930                 935                 940                 


Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu 
945                 950                 955                 960 


Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys 
                965                 970                 975     


Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro 
            980                 985                 990         


Asp Lys Arg Pro Val Phe Ala Asp  Ile Ser Lys Asp Leu  Glu Lys Met 
        995                 1000                 1005             


Met Val  Lys Arg Arg Asp Tyr  Leu Asp Leu Ala Ala  Ser Thr Pro 
    1010                 1015                 1020             


Ser Asp  Ser Leu Ile Tyr Asp  Asp Gly Leu Ser Glu  Glu Glu Thr 
    1025                 1030                 1035             


Pro Leu  Val Asp Cys Asn Asn  Ala Pro Leu Pro Arg  Ala Leu Pro 
    1040                 1045                 1050             


Ser Thr  Trp Ile Glu Asn Lys  Leu Tyr Gly Met Ser  Asp Pro Asn 
    1055                 1060                 1065             


Trp Pro  Gly Glu Ser Pro Val  Pro Leu Thr Arg Ala  Asp Gly Thr 
    1070                 1075                 1080             


Asn Thr  Gly Phe Pro Arg Tyr  Pro Asn Asp Ser Val  Tyr Ala Asn 
    1085                 1090                 1095             


Trp Met  Leu Ser Pro Ser Ala  Ala Lys Leu Met Asp  Thr Phe Asp 
    1100                 1105                 1110             


Ser 
    


<210>  463
<211>  2347
<212>  PRT
<213>  Homo sapiens

<400>  463

Met Lys Asn Ile Tyr Cys Leu Ile Pro Lys Leu Val Asn Phe Ala Thr 
1               5                   10                  15      


Leu Gly Cys Leu Trp Ile Ser Val Val Gln Cys Thr Val Leu Asn Ser 
            20                  25                  30          


Cys Leu Lys Ser Cys Val Thr Asn Leu Gly Gln Gln Leu Asp Leu Gly 
        35                  40                  45              


Thr Pro His Asn Leu Ser Glu Pro Cys Ile Gln Gly Cys His Phe Trp 
    50                  55                  60                  


Asn Ser Val Asp Gln Lys Asn Cys Ala Leu Lys Cys Arg Glu Ser Cys 
65                  70                  75                  80  


Glu Val Gly Cys Ser Ser Ala Glu Gly Ala Tyr Glu Glu Glu Val Leu 
                85                  90                  95      


Glu Asn Ala Asp Leu Pro Thr Ala Pro Phe Ala Ser Ser Ile Gly Ser 
            100                 105                 110         


His Asn Met Thr Leu Arg Trp Lys Ser Ala Asn Phe Ser Gly Val Lys 
        115                 120                 125             


Tyr Ile Ile Gln Trp Lys Tyr Ala Gln Leu Leu Gly Ser Trp Thr Tyr 
    130                 135                 140                 


Thr Lys Thr Val Ser Arg Pro Ser Tyr Val Val Lys Pro Leu His Pro 
145                 150                 155                 160 


Phe Thr Glu Tyr Ile Phe Arg Val Val Trp Ile Phe Thr Ala Gln Leu 
                165                 170                 175     


Gln Leu Tyr Ser Pro Pro Ser Pro Ser Tyr Arg Thr His Pro His Gly 
            180                 185                 190         


Val Pro Glu Thr Ala Pro Leu Ile Arg Asn Ile Glu Ser Ser Ser Pro 
        195                 200                 205             


Asp Thr Val Glu Val Ser Trp Asp Pro Pro Gln Phe Pro Gly Gly Pro 
    210                 215                 220                 


Ile Leu Gly Tyr Asn Leu Arg Leu Ile Ser Lys Asn Gln Lys Leu Asp 
225                 230                 235                 240 


Ala Gly Thr Gln Arg Thr Ser Phe Gln Phe Tyr Ser Thr Leu Pro Asn 
                245                 250                 255     


Thr Ile Tyr Arg Phe Ser Ile Ala Ala Val Asn Glu Val Gly Glu Gly 
            260                 265                 270         


Pro Glu Ala Glu Ser Ser Ile Thr Thr Ser Ser Ser Ala Val Gln Gln 
        275                 280                 285             


Glu Glu Gln Trp Leu Phe Leu Ser Arg Lys Thr Ser Leu Arg Lys Arg 
    290                 295                 300                 


Ser Leu Lys His Leu Val Asp Glu Ala His Cys Leu Arg Leu Asp Ala 
305                 310                 315                 320 


Ile Tyr His Asn Ile Thr Gly Ile Ser Val Asp Val His Gln Gln Ile 
                325                 330                 335     


Val Tyr Phe Ser Glu Gly Thr Leu Ile Trp Ala Lys Lys Ala Ala Asn 
            340                 345                 350         


Met Ser Asp Val Ser Asp Leu Arg Ile Phe Tyr Arg Gly Ser Gly Leu 
        355                 360                 365             


Ile Ser Ser Ile Ser Ile Asp Trp Leu Tyr Gln Arg Met Tyr Phe Ile 
    370                 375                 380                 


Met Asp Glu Leu Val Cys Val Cys Asp Leu Glu Asn Cys Ser Asn Ile 
385                 390                 395                 400 


Glu Glu Ile Thr Pro Pro Ser Ile Ser Ala Pro Gln Lys Ile Val Ala 
                405                 410                 415     


Asp Ser Tyr Asn Gly Tyr Val Phe Tyr Leu Leu Arg Asp Gly Ile Tyr 
            420                 425                 430         


Arg Ala Asp Leu Pro Val Pro Ser Gly Arg Cys Ala Glu Ala Val Arg 
        435                 440                 445             


Ile Val Glu Ser Cys Thr Leu Lys Asp Phe Ala Ile Lys Pro Gln Ala 
    450                 455                 460                 


Lys Arg Ile Ile Tyr Phe Asn Asp Thr Ala Gln Val Phe Met Ser Thr 
465                 470                 475                 480 


Phe Leu Asp Gly Ser Ala Ser His Leu Ile Leu Pro Arg Ile Pro Phe 
                485                 490                 495     


Ala Asp Val Lys Ser Phe Ala Cys Glu Asn Asn Asp Phe Leu Val Thr 
            500                 505                 510         


Asp Gly Lys Val Ile Phe Gln Gln Asp Ala Leu Ser Phe Asn Glu Phe 
        515                 520                 525             


Ile Val Gly Cys Asp Leu Ser His Ile Glu Glu Phe Gly Phe Gly Asn 
    530                 535                 540                 


Leu Val Ile Phe Gly Ser Ser Ser Gln Leu His Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Pro Gln Glu Leu Ser Val Leu Phe Gly Ser His Gln Ala Leu Val Gln 
                565                 570                 575     


Trp Lys Pro Pro Ala Leu Ala Ile Gly Ala Asn Val Ile Leu Ile Ser 
            580                 585                 590         


Asp Ile Ile Glu Leu Phe Glu Leu Gly Pro Ser Ala Trp Gln Asn Trp 
        595                 600                 605             


Thr Tyr Glu Val Lys Val Ser Thr Gln Asp Pro Pro Glu Val Thr His 
    610                 615                 620                 


Ile Phe Leu Asn Ile Ser Gly Thr Met Leu Asn Val Pro Glu Leu Gln 
625                 630                 635                 640 


Ser Ala Met Lys Tyr Lys Val Ser Val Arg Ala Ser Ser Pro Lys Arg 
                645                 650                 655     


Pro Gly Pro Trp Ser Glu Pro Ser Val Gly Thr Thr Leu Val Pro Ala 
            660                 665                 670         


Ser Glu Pro Pro Phe Ile Met Ala Val Lys Glu Asp Gly Leu Trp Ser 
        675                 680                 685             


Lys Pro Leu Asn Ser Phe Gly Pro Gly Glu Phe Leu Ser Ser Asp Ile 
    690                 695                 700                 


Gly Asn Val Ser Asp Met Asp Trp Tyr Asn Asn Ser Leu Tyr Tyr Ser 
705                 710                 715                 720 


Asp Thr Lys Gly Asp Val Phe Val Trp Leu Leu Asn Gly Thr Asp Ile 
                725                 730                 735     


Ser Glu Asn Tyr His Leu Pro Ser Ile Ala Gly Ala Gly Ala Leu Ala 
            740                 745                 750         


Phe Glu Trp Leu Gly His Phe Leu Tyr Trp Ala Gly Lys Thr Tyr Val 
        755                 760                 765             


Ile Gln Arg Gln Ser Val Leu Thr Gly His Thr Asp Ile Val Thr His 
    770                 775                 780                 


Val Lys Leu Leu Val Asn Asp Met Val Val Asp Ser Val Gly Gly Tyr 
785                 790                 795                 800 


Leu Tyr Trp Thr Thr Leu Tyr Ser Val Glu Ser Thr Arg Leu Asn Gly 
                805                 810                 815     


Glu Ser Ser Leu Val Leu Gln Thr Gln Pro Trp Phe Ser Gly Lys Lys 
            820                 825                 830         


Val Ile Ala Leu Thr Leu Asp Leu Ser Asp Gly Leu Leu Tyr Trp Leu 
        835                 840                 845             


Val Gln Asp Ser Gln Cys Ile His Leu Tyr Thr Ala Val Leu Arg Gly 
    850                 855                 860                 


Gln Ser Thr Gly Asp Thr Thr Ile Thr Glu Phe Ala Ala Trp Ser Thr 
865                 870                 875                 880 


Ser Glu Ile Ser Gln Asn Ala Leu Met Tyr Tyr Ser Gly Arg Leu Phe 
                885                 890                 895     


Trp Ile Asn Gly Phe Arg Ile Ile Thr Thr Gln Glu Ile Gly Gln Lys 
            900                 905                 910         


Thr Ser Val Ser Val Leu Glu Pro Ala Arg Phe Asn Gln Phe Thr Ile 
        915                 920                 925             


Ile Gln Thr Ser Leu Lys Pro Leu Pro Gly Asn Phe Ser Phe Thr Pro 
    930                 935                 940                 


Lys Val Ile Pro Asp Ser Val Gln Glu Ser Ser Phe Arg Ile Glu Gly 
945                 950                 955                 960 


Asn Ala Ser Ser Phe Gln Ile Leu Trp Asn Gly Pro Pro Ala Val Asp 
                965                 970                 975     


Trp Gly Val Val Phe Tyr Ser Val Glu Phe Ser Ala His Ser Lys Phe 
            980                 985                 990         


Leu Ala Ser Glu Gln His Ser Leu  Pro Val Phe Thr Val  Glu Gly Leu 
        995                 1000                 1005             


Glu Pro  Tyr Ala Leu Phe Asn  Leu Ser Val Thr Pro  Tyr Thr Tyr 
    1010                 1015                 1020             


Trp Gly  Lys Gly Pro Lys Thr  Ser Leu Ser Leu Arg  Ala Pro Glu 
    1025                 1030                 1035             


Thr Val  Pro Ser Ala Pro Glu  Asn Pro Arg Ile Phe  Ile Leu Pro 
    1040                 1045                 1050             


Ser Gly  Lys Cys Cys Asn Lys  Asn Glu Val Val Val  Glu Phe Arg 
    1055                 1060                 1065             


Trp Asn  Lys Pro Lys His Glu  Asn Gly Val Leu Thr  Lys Phe Glu 
    1070                 1075                 1080             


Ile Phe  Tyr Asn Ile Ser Asn  Gln Ser Ile Thr Asn  Lys Thr Cys 
    1085                 1090                 1095             


Glu Asp  Trp Ile Ala Val Asn  Val Thr Pro Ser Val  Met Ser Phe 
    1100                 1105                 1110             


Gln Leu  Glu Gly Met Ser Pro  Arg Cys Phe Ile Ala  Phe Gln Val 
    1115                 1120                 1125             


Arg Ala  Phe Thr Ser Lys Gly  Pro Gly Pro Tyr Ala  Asp Val Val 
    1130                 1135                 1140             


Lys Ser  Thr Thr Ser Glu Ile  Asn Pro Phe Pro His  Leu Ile Thr 
    1145                 1150                 1155             


Leu Leu  Gly Asn Lys Ile Val  Phe Leu Asp Met Asp  Gln Asn Gln 
    1160                 1165                 1170             


Val Val  Trp Thr Phe Ser Ala  Glu Arg Val Ile Ser  Ala Val Cys 
    1175                 1180                 1185             


Tyr Thr  Ala Asp Asn Glu Met  Gly Tyr Tyr Ala Glu  Gly Asp Ser 
    1190                 1195                 1200             


Leu Phe  Leu Leu His Leu His  Asn Arg Ser Ser Ser  Glu Leu Phe 
    1205                 1210                 1215             


Gln Asp  Ser Leu Val Phe Asp  Ile Thr Val Ile Thr  Ile Asp Trp 
    1220                 1225                 1230             


Ile Ser  Arg His Leu Tyr Phe  Ala Leu Lys Glu Ser  Gln Asn Gly 
    1235                 1240                 1245             


Met Gln  Val Phe Asp Val Asp  Leu Glu His Lys Val  Lys Tyr Pro 
    1250                 1255                 1260             


Arg Glu  Val Lys Ile His Asn  Arg Asn Ser Thr Ile  Ile Ser Phe 
    1265                 1270                 1275             


Ser Val  Tyr Pro Leu Leu Ser  Arg Leu Tyr Trp Thr  Glu Val Ser 
    1280                 1285                 1290             


Asn Phe  Gly Tyr Gln Met Phe  Tyr Tyr Ser Ile Ile  Ser His Thr 
    1295                 1300                 1305             


Leu His  Arg Ile Leu Gln Pro  Thr Ala Thr Asn Gln  Gln Asn Lys 
    1310                 1315                 1320             


Arg Asn  Gln Cys Ser Cys Asn  Val Thr Glu Phe Glu  Leu Ser Gly 
    1325                 1330                 1335             


Ala Met  Ala Ile Asp Thr Ser  Asn Leu Glu Lys Pro  Leu Ile Tyr 
    1340                 1345                 1350             


Phe Ala  Lys Ala Gln Glu Ile  Trp Ala Met Asp Leu  Glu Gly Cys 
    1355                 1360                 1365             


Gln Cys  Trp Arg Val Ile Thr  Val Pro Ala Met Leu  Ala Gly Lys 
    1370                 1375                 1380             


Thr Leu  Val Ser Leu Thr Val  Asp Gly Asp Leu Ile  Tyr Trp Ile 
    1385                 1390                 1395             


Ile Thr  Ala Lys Asp Ser Thr  Gln Ile Tyr Gln Ala  Lys Lys Gly 
    1400                 1405                 1410             


Asn Gly  Ala Ile Val Ser Gln  Val Lys Ala Leu Arg  Ser Arg His 
    1415                 1420                 1425             


Ile Leu  Ala Tyr Ser Ser Val  Met Gln Pro Phe Pro  Asp Lys Ala 
    1430                 1435                 1440             


Phe Leu  Ser Leu Ala Ser Asp  Thr Val Glu Pro Thr  Ile Leu Asn 
    1445                 1450                 1455             


Ala Thr  Asn Thr Ser Leu Thr  Ile Arg Leu Pro Leu  Ala Lys Thr 
    1460                 1465                 1470             


Asn Leu  Thr Trp Tyr Gly Ile  Thr Ser Pro Thr Pro  Thr Tyr Leu 
    1475                 1480                 1485             


Val Tyr  Tyr Ala Glu Val Asn  Asp Arg Lys Asn Ser  Ser Asp Leu 
    1490                 1495                 1500             


Lys Tyr  Arg Ile Leu Glu Phe  Gln Asp Ser Ile Ala  Leu Ile Glu 
    1505                 1510                 1515             


Asp Leu  Gln Pro Phe Ser Thr  Tyr Met Ile Gln Ile  Ala Val Lys 
    1520                 1525                 1530             


Asn Tyr  Tyr Ser Asp Pro Leu  Glu His Leu Pro Pro  Gly Lys Glu 
    1535                 1540                 1545             


Ile Trp  Gly Lys Thr Lys Asn  Gly Val Pro Glu Ala  Val Gln Leu 
    1550                 1555                 1560             


Ile Asn  Thr Thr Val Arg Ser  Asp Thr Ser Leu Ile  Ile Ser Trp 
    1565                 1570                 1575             


Arg Glu  Ser His Lys Pro Asn  Gly Pro Lys Glu Ser  Val Arg Tyr 
    1580                 1585                 1590             


Gln Leu  Ala Ile Ser His Leu  Ala Leu Ile Pro Glu  Thr Pro Leu 
    1595                 1600                 1605             


Arg Gln  Ser Glu Phe Pro Asn  Gly Arg Leu Thr Leu  Leu Val Thr 
    1610                 1615                 1620             


Arg Leu  Ser Gly Gly Asn Ile  Tyr Val Leu Lys Val  Leu Ala Cys 
    1625                 1630                 1635             


His Ser  Glu Glu Met Trp Cys  Thr Glu Ser His Pro  Val Thr Val 
    1640                 1645                 1650             


Glu Met  Phe Asn Thr Pro Glu  Lys Pro Tyr Ser Leu  Val Pro Glu 
    1655                 1660                 1665             


Asn Thr  Ser Leu Gln Phe Asn  Trp Lys Ala Pro Leu  Asn Val Asn 
    1670                 1675                 1680             


Leu Ile  Arg Phe Trp Val Glu  Leu Gln Lys Trp Lys  Tyr Asn Glu 
    1685                 1690                 1695             


Phe Tyr  His Val Lys Thr Ser  Cys Ser Gln Gly Pro  Ala Tyr Val 
    1700                 1705                 1710             


Cys Asn  Ile Thr Asn Leu Gln  Pro Tyr Thr Ser Tyr  Asn Val Arg 
    1715                 1720                 1725             


Val Val  Val Val Tyr Lys Thr  Gly Glu Asn Ser Thr  Ser Leu Pro 
    1730                 1735                 1740             


Glu Ser  Phe Lys Thr Lys Ala  Gly Val Pro Asn Lys  Pro Gly Ile 
    1745                 1750                 1755             


Pro Lys  Leu Leu Glu Gly Ser  Lys Asn Ser Ile Gln  Trp Glu Lys 
    1760                 1765                 1770             


Ala Glu  Asp Asn Gly Cys Arg  Ile Thr Tyr Tyr Ile  Leu Glu Ile 
    1775                 1780                 1785             


Arg Lys  Ser Thr Ser Asn Asn  Leu Gln Asn Gln Asn  Leu Arg Trp 
    1790                 1795                 1800             


Lys Met  Thr Phe Asn Gly Ser  Cys Ser Ser Val Cys  Thr Trp Lys 
    1805                 1810                 1815             


Ser Lys  Asn Leu Lys Gly Ile  Phe Gln Phe Arg Val  Val Ala Ala 
    1820                 1825                 1830             


Asn Asn  Leu Gly Phe Gly Glu  Tyr Ser Gly Ile Ser  Glu Asn Ile 
    1835                 1840                 1845             


Ile Leu  Val Gly Asp Asp Phe  Trp Ile Pro Glu Thr  Ser Phe Ile 
    1850                 1855                 1860             


Leu Thr  Ile Ile Val Gly Ile  Phe Leu Val Val Thr  Ile Pro Leu 
    1865                 1870                 1875             


Thr Phe  Val Trp His Arg Arg  Leu Lys Asn Gln Lys  Ser Ala Lys 
    1880                 1885                 1890             


Glu Gly  Val Thr Val Leu Ile  Asn Glu Asp Lys Glu  Leu Ala Glu 
    1895                 1900                 1905             


Leu Arg  Gly Leu Ala Ala Gly  Val Gly Leu Ala Asn  Ala Cys Tyr 
    1910                 1915                 1920             


Ala Ile  His Thr Leu Pro Thr  Gln Glu Glu Ile Glu  Asn Leu Pro 
    1925                 1930                 1935             


Ala Phe  Pro Arg Glu Lys Leu  Thr Leu Arg Leu Leu  Leu Gly Ser 
    1940                 1945                 1950             


Gly Ala  Phe Gly Glu Val Tyr  Glu Gly Thr Ala Val  Asp Ile Leu 
    1955                 1960                 1965             


Gly Val  Gly Ser Gly Glu Ile  Lys Val Ala Val Lys  Thr Leu Lys 
    1970                 1975                 1980             


Lys Gly  Ser Thr Asp Gln Glu  Lys Ile Glu Phe Leu  Lys Glu Ala 
    1985                 1990                 1995             


His Leu  Met Ser Lys Phe Asn  His Pro Asn Ile Leu  Lys Gln Leu 
    2000                 2005                 2010             


Gly Val  Cys Leu Leu Asn Glu  Pro Gln Tyr Ile Ile  Leu Glu Leu 
    2015                 2020                 2025             


Met Glu  Gly Gly Asp Leu Leu  Thr Tyr Leu Arg Lys  Ala Arg Met 
    2030                 2035                 2040             


Ala Thr  Phe Tyr Gly Pro Leu  Leu Thr Leu Val Asp  Leu Val Asp 
    2045                 2050                 2055             


Leu Cys  Val Asp Ile Ser Lys  Gly Cys Val Tyr Leu  Glu Arg Met 
    2060                 2065                 2070             


His Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Ser 
    2075                 2080                 2085             


Val Lys  Asp Tyr Thr Ser Pro  Arg Ile Val Lys Ile  Gly Asp Phe 
    2090                 2095                 2100             


Gly Leu  Ala Arg Asp Ile Tyr  Lys Asn Asp Tyr Tyr  Arg Lys Arg 
    2105                 2110                 2115             


Gly Glu  Gly Leu Leu Pro Val  Arg Trp Met Ala Pro  Glu Ser Leu 
    2120                 2125                 2130             


Met Asp  Gly Ile Phe Thr Thr  Gln Ser Asp Val Trp  Ser Phe Gly 
    2135                 2140                 2145             


Ile Leu  Ile Trp Glu Ile Leu  Thr Leu Gly His Gln  Pro Tyr Pro 
    2150                 2155                 2160             


Ala His  Ser Asn Leu Asp Val  Leu Asn Tyr Val Gln  Thr Gly Gly 
    2165                 2170                 2175             


Arg Leu  Glu Pro Pro Arg Asn  Cys Pro Asp Asp Leu  Trp Asn Leu 
    2180                 2185                 2190             


Met Thr  Gln Cys Trp Ala Gln  Glu Pro Asp Gln Arg  Pro Thr Phe 
    2195                 2200                 2205             


His Arg  Ile Gln Asp Gln Leu  Gln Leu Phe Arg Asn  Phe Phe Leu 
    2210                 2215                 2220             


Asn Ser  Ile Tyr Lys Ser Arg  Asp Glu Ala Asn Asn  Ser Gly Val 
    2225                 2230                 2235             


Ile Asn  Glu Ser Phe Glu Gly  Glu Asp Gly Asp Val  Ile Cys Leu 
    2240                 2245                 2250             


Asn Ser  Asp Asp Ile Met Pro  Val Ala Leu Met Glu  Thr Lys Asn 
    2255                 2260                 2265             


Arg Glu  Gly Leu Asn Tyr Met  Val Leu Ala Thr Glu  Cys Gly Gln 
    2270                 2275                 2280             


Gly Glu  Glu Lys Ser Glu Gly  Pro Leu Gly Ser Gln  Glu Ser Glu 
    2285                 2290                 2295             


Ser Cys  Gly Leu Arg Lys Glu  Glu Lys Glu Pro His  Ala Asp Lys 
    2300                 2305                 2310             


Asp Phe  Cys Gln Glu Lys Gln  Val Ala Tyr Cys Pro  Ser Gly Lys 
    2315                 2320                 2325             


Pro Glu  Gly Leu Asn Tyr Ala  Cys Leu Thr His Ser  Gly Tyr Gly 
    2330                 2335                 2340             


Asp Gly  Ser Asp 
    2345         


<210>  464
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
    290                 295                 300                 


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val 
305                 310                 315                 320 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
                325                 330                 335     


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu 
            340                 345                 350         


Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp 
        355                 360                 365             


Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
    370                 375                 380                 


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
385                 390                 395                 400 


Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp 
                405                 410                 415     


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
            420                 425                 430         


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
        435                 440                 445             


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys 
    450                 455                 460                 


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
465                 470                 475                 480 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
                485                 490                 495     


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
        515                 520                 525             


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
    530                 535                 540                 


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
545                 550                 555                 560 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
                565                 570                 575     


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
            580                 585                 590         


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
        595                 600                 605         


<210>  465
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  465

Met Asp Ser Leu Ala Ser Leu Val Leu Cys Gly Val Ser Leu Leu Leu 
1               5                   10                  15      


Ser Gly Thr Val Glu Gly Ala Met Asp Leu Ile Leu Ile Asn Ser Leu 
            20                  25                  30          


Pro Leu Val Ser Asp Ala Glu Thr Ser Leu Thr Cys Ile Ala Ser Gly 
        35                  40                  45              


Trp Arg Pro His Glu Pro Ile Thr Ile Gly Arg Asp Phe Glu Ala Leu 
    50                  55                  60                  


Met Asn Gln His Gln Asp Pro Leu Glu Val Thr Gln Asp Val Thr Arg 
65                  70                  75                  80  


Glu Trp Ala Lys Lys Val Val Trp Lys Arg Glu Lys Ala Ser Lys Ile 
                85                  90                  95      


Asn Gly Ala Tyr Phe Cys Glu Gly Arg Val Arg Gly Glu Ala Ile Arg 
            100                 105                 110         


Ile Arg Thr Met Lys Met Arg Gln Gln Ala Ser Phe Leu Pro Ala Thr 
        115                 120                 125             


Leu Thr Met Thr Val Asp Lys Gly Asp Asn Val Asn Ile Ser Phe Lys 
    130                 135                 140                 


Lys Val Leu Ile Lys Glu Glu Asp Ala Val Ile Tyr Lys Asn Gly Ser 
145                 150                 155                 160 


Phe Ile His Ser Val Pro Arg His Glu Val Pro Asp Ile Leu Glu Val 
                165                 170                 175     


His Leu Pro His Ala Gln Pro Gln Asp Ala Gly Val Tyr Ser Ala Arg 
            180                 185                 190         


Tyr Ile Gly Gly Asn Leu Phe Thr Ser Ala Phe Thr Arg Leu Ile Val 
        195                 200                 205             


Arg Arg Cys Glu Ala Gln Lys Trp Gly Pro Glu Cys Asn His Leu Cys 
    210                 215                 220                 


Thr Ala Cys Met Asn Asn Gly Val Cys His Glu Asp Thr Gly Glu Cys 
225                 230                 235                 240 


Ile Cys Pro Pro Gly Phe Met Gly Arg Thr Cys Glu Lys Ala Cys Glu 
                245                 250                 255     


Leu His Thr Phe Gly Arg Thr Cys Lys Glu Arg Cys Ser Gly Gln Glu 
            260                 265                 270         


Gly Cys Lys Ser Tyr Val Phe Cys Leu Pro Asp Pro Tyr Gly Cys Ser 
        275                 280                 285             


Cys Ala Thr Gly Trp Lys Gly Leu Gln Cys Asn Glu Ala Cys His Pro 
    290                 295                 300                 


Gly Phe Tyr Gly Pro Asp Cys Lys Leu Arg Cys Ser Cys Asn Asn Gly 
305                 310                 315                 320 


Glu Met Cys Asp Arg Phe Gln Gly Cys Leu Cys Ser Pro Gly Trp Gln 
                325                 330                 335     


Gly Leu Gln Cys Glu Arg Glu Gly Ile Pro Arg Met Thr Pro Lys Ile 
            340                 345                 350         


Val Asp Leu Pro Asp His Ile Glu Val Asn Ser Gly Lys Phe Asn Pro 
        355                 360                 365             


Ile Cys Lys Ala Ser Gly Trp Pro Leu Pro Thr Asn Glu Glu Met Thr 
    370                 375                 380                 


Leu Val Lys Pro Asp Gly Thr Val Leu His Pro Lys Asp Phe Asn His 
385                 390                 395                 400 


Thr Asp His Phe Ser Val Ala Ile Phe Thr Ile His Arg Ile Leu Pro 
                405                 410                 415     


Pro Asp Ser Gly Val Trp Val Cys Ser Val Asn Thr Val Ala Gly Met 
            420                 425                 430         


Val Glu Lys Pro Phe Asn Ile Ser Val Lys Val Leu Pro Lys Pro Leu 
        435                 440                 445             


Asn Ala Pro Asn Val Ile Asp Thr Gly His Asn Phe Ala Val Ile Asn 
    450                 455                 460                 


Ile Ser Ser Glu Pro Tyr Phe Gly Asp Gly Pro Ile Lys Ser Lys Lys 
465                 470                 475                 480 


Leu Leu Tyr Lys Pro Val Asn His Tyr Glu Ala Trp Gln His Ile Gln 
                485                 490                 495     


Val Thr Asn Glu Ile Val Thr Leu Asn Tyr Leu Glu Pro Arg Thr Glu 
            500                 505                 510         


Tyr Glu Leu Cys Val Gln Leu Val Arg Arg Gly Glu Gly Gly Glu Gly 
        515                 520                 525             


His Pro Gly Pro Val Arg Arg Phe Thr Thr Ala Ser Ile Gly Leu Pro 
    530                 535                 540                 


Pro Pro Arg Gly Leu Asn Leu Leu Pro Lys Ser Gln Thr Thr Leu Asn 
545                 550                 555                 560 


Leu Thr Trp Gln Pro Ile Phe Pro Ser Ser Glu Asp Asp Phe Tyr Val 
                565                 570                 575     


Glu Val Glu Arg Arg Ser Val Gln Lys Ser Asp Gln Gln Asn Ile Lys 
            580                 585                 590         


Val Pro Gly Asn Leu Thr Ser Val Leu Leu Asn Asn Leu His Pro Arg 
        595                 600                 605             


Glu Gln Tyr Val Val Arg Ala Arg Val Asn Thr Lys Ala Gln Gly Glu 
    610                 615                 620                 


Trp Ser Glu Asp Leu Thr Ala Trp Thr Leu Ser Asp Ile Leu Pro Pro 
625                 630                 635                 640 


Gln Pro Glu Asn Ile Lys Ile Ser Asn Ile Thr His Ser Ser Ala Val 
                645                 650                 655     


Ile Ser Trp Thr Ile Leu Asp Gly Tyr Ser Ile Ser Ser Ile Thr Ile 
            660                 665                 670         


Arg Tyr Lys Val Gln Gly Lys Asn Glu Asp Gln His Val Asp Val Lys 
        675                 680                 685             


Ile Lys Asn Ala Thr Ile Thr Gln Tyr Gln Leu Lys Gly Leu Glu Pro 
    690                 695                 700                 


Glu Thr Ala Tyr Gln Val Asp Ile Phe Ala Glu Asn Asn Ile Gly Ser 
705                 710                 715                 720 


Ser Asn Pro Ala Phe Ser His Glu Leu Val Thr Leu Pro Glu Ser Gln 
                725                 730                 735     


Ala Pro Ala Asp Leu Gly Gly Gly Lys Met Leu Leu Ile Ala Ile Leu 
            740                 745                 750         


Gly Ser Ala Gly Met Thr Cys Leu Thr Val Leu Leu Ala Phe Leu Ile 
        755                 760                 765             


Ile Leu Gln Leu Lys Arg Ala Asn Val Gln Arg Arg Met Ala Gln Ala 
    770                 775                 780                 


Phe Gln Asn Val Arg Glu Glu Pro Ala Val Gln Phe Asn Ser Gly Thr 
785                 790                 795                 800 


Leu Ala Leu Asn Arg Lys Val Lys Asn Asn Pro Asp Pro Thr Ile Tyr 
                805                 810                 815     


Pro Val Leu Asp Trp Asn Asp Ile Lys Phe Gln Asp Val Ile Gly Glu 
            820                 825                 830         


Gly Asn Phe Gly Gln Val Leu Lys Ala Arg Ile Lys Lys Asp Gly Leu 
        835                 840                 845             


Arg Met Asp Ala Ala Ile Lys Arg Met Lys Glu Tyr Ala Ser Lys Asp 
    850                 855                 860                 


Asp His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly 
865                 870                 875                 880 


His His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Glu His Arg Gly 
                885                 890                 895     


Tyr Leu Tyr Leu Ala Ile Glu Tyr Ala Pro His Gly Asn Leu Leu Asp 
            900                 905                 910         


Phe Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Ile 
        915                 920                 925             


Ala Asn Ser Thr Ala Ser Thr Leu Ser Ser Gln Gln Leu Leu His Phe 
    930                 935                 940                 


Ala Ala Asp Val Ala Arg Gly Met Asp Tyr Leu Ser Gln Lys Gln Phe 
945                 950                 955                 960 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Gly Glu Asn Tyr 
                965                 970                 975     


Val Ala Lys Ile Ala Asp Phe Gly Leu Ser Arg Gly Gln Glu Val Tyr 
            980                 985                 990         


Val Lys Lys Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
        995                 1000                 1005             


Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Asn Ser Asp  Val Trp Ser 
    1010                 1015                 1020             


Tyr Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1025                 1030                 1035             


Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1040                 1045                 1050             


Gly Tyr  Arg Leu Glu Lys Pro  Leu Asn Cys Asp Asp  Glu Val Tyr 
    1055                 1060                 1065             


Asp Leu  Met Arg Gln Cys Trp  Arg Glu Lys Pro Tyr  Glu Arg Pro 
    1070                 1075                 1080             


Ser Phe  Ala Gln Ile Leu Val  Ser Leu Asn Arg Met  Leu Glu Glu 
    1085                 1090                 1095             


Arg Lys  Thr Tyr Val Asn Thr  Thr Leu Tyr Glu Lys  Phe Thr Tyr 
    1100                 1105                 1110             


Ala Gly  Ile Asp Cys Ser Ala  Glu Glu Ala Ala 
    1115                 1120                 


<210>  466
<211>  1138
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Val Trp Arg Val Pro Pro Phe Leu Leu Pro Ile Leu Phe Leu Ala 
1               5                   10                  15      


Ser His Val Gly Ala Ala Val Asp Leu Thr Leu Leu Ala Asn Leu Arg 
            20                  25                  30          


Leu Thr Asp Pro Gln Arg Phe Phe Leu Thr Cys Val Ser Gly Glu Ala 
        35                  40                  45              


Gly Ala Gly Arg Gly Ser Asp Ala Trp Gly Pro Pro Leu Leu Leu Glu 
    50                  55                  60                  


Lys Asp Asp Arg Ile Val Arg Thr Pro Pro Gly Pro Pro Leu Arg Leu 
65                  70                  75                  80  


Ala Arg Asn Gly Ser His Gln Val Thr Leu Arg Gly Phe Ser Lys Pro 
                85                  90                  95      


Ser Asp Leu Val Gly Val Phe Ser Cys Val Gly Gly Ala Gly Ala Arg 
            100                 105                 110         


Arg Thr Arg Val Ile Tyr Val His Asn Ser Pro Gly Ala His Leu Leu 
        115                 120                 125             


Pro Asp Lys Val Thr His Thr Val Asn Lys Gly Asp Thr Ala Val Leu 
    130                 135                 140                 


Ser Ala Arg Val His Lys Glu Lys Gln Thr Asp Val Ile Trp Lys Ser 
145                 150                 155                 160 


Asn Gly Ser Tyr Phe Tyr Thr Leu Asp Trp His Glu Ala Gln Asp Gly 
                165                 170                 175     


Arg Phe Leu Leu Gln Leu Pro Asn Val Gln Pro Pro Ser Ser Gly Ile 
            180                 185                 190         


Tyr Ser Ala Thr Tyr Leu Glu Ala Ser Pro Leu Gly Ser Ala Phe Phe 
        195                 200                 205             


Arg Leu Ile Val Arg Gly Cys Gly Ala Gly Arg Trp Gly Pro Gly Cys 
    210                 215                 220                 


Thr Lys Glu Cys Pro Gly Cys Leu His Gly Gly Val Cys His Asp His 
225                 230                 235                 240 


Asp Gly Glu Cys Val Cys Pro Pro Gly Phe Thr Gly Thr Arg Cys Glu 
                245                 250                 255     


Gln Ala Cys Arg Glu Gly Arg Phe Gly Gln Ser Cys Gln Glu Gln Cys 
            260                 265                 270         


Pro Gly Ile Ser Gly Cys Arg Gly Leu Thr Phe Cys Leu Pro Asp Pro 
        275                 280                 285             


Tyr Gly Cys Ser Cys Gly Ser Gly Trp Arg Gly Ser Gln Cys Gln Glu 
    290                 295                 300                 


Ala Cys Ala Pro Gly His Phe Gly Ala Asp Cys Arg Leu Gln Cys Gln 
305                 310                 315                 320 


Cys Gln Asn Gly Gly Thr Cys Asp Arg Phe Ser Gly Cys Val Cys Pro 
                325                 330                 335     


Ser Gly Trp His Gly Val His Cys Glu Lys Ser Asp Arg Ile Pro Gln 
            340                 345                 350         


Ile Leu Asn Met Ala Ser Glu Leu Glu Phe Asn Leu Glu Thr Met Pro 
        355                 360                 365             


Arg Ile Asn Cys Ala Ala Ala Gly Asn Pro Phe Pro Val Arg Gly Ser 
    370                 375                 380                 


Ile Glu Leu Arg Lys Pro Asp Gly Thr Val Leu Leu Ser Thr Lys Ala 
385                 390                 395                 400 


Ile Val Glu Pro Glu Lys Thr Thr Ala Glu Phe Glu Val Pro Arg Leu 
                405                 410                 415     


Val Leu Ala Asp Ser Gly Phe Trp Glu Cys Arg Val Ser Thr Ser Gly 
            420                 425                 430         


Gly Gln Asp Ser Arg Arg Phe Lys Val Asn Val Lys Val Pro Pro Val 
        435                 440                 445             


Pro Leu Ala Ala Pro Arg Leu Leu Thr Lys Gln Ser Arg Gln Leu Val 
    450                 455                 460                 


Val Ser Pro Leu Val Ser Phe Ser Gly Asp Gly Pro Ile Ser Thr Val 
465                 470                 475                 480 


Arg Leu His Tyr Arg Pro Gln Asp Ser Thr Met Asp Trp Ser Thr Ile 
                485                 490                 495     


Val Val Asp Pro Ser Glu Asn Val Thr Leu Met Asn Leu Arg Pro Lys 
            500                 505                 510         


Thr Gly Tyr Ser Val Arg Val Gln Leu Ser Arg Pro Gly Glu Gly Gly 
        515                 520                 525             


Glu Gly Ala Trp Gly Pro Pro Thr Leu Met Thr Thr Asp Cys Pro Glu 
    530                 535                 540                 


Pro Leu Leu Gln Pro Trp Leu Glu Gly Trp His Val Glu Gly Thr Asp 
545                 550                 555                 560 


Arg Leu Arg Val Ser Trp Ser Leu Pro Leu Val Pro Gly Pro Leu Val 
                565                 570                 575     


Gly Asp Gly Phe Leu Leu Arg Leu Trp Asp Gly Thr Arg Gly Gln Glu 
            580                 585                 590         


Arg Arg Glu Asn Val Ser Ser Pro Gln Ala Arg Thr Ala Leu Leu Thr 
        595                 600                 605             


Gly Leu Thr Pro Gly Thr His Tyr Gln Leu Asp Val Gln Leu Tyr His 
    610                 615                 620                 


Cys Thr Leu Leu Gly Pro Ala Ser Pro Pro Ala His Val Leu Leu Pro 
625                 630                 635                 640 


Pro Ser Gly Pro Pro Ala Pro Arg His Leu His Ala Gln Ala Leu Ser 
                645                 650                 655     


Asp Ser Glu Ile Gln Leu Thr Trp Lys His Pro Glu Ala Leu Pro Gly 
            660                 665                 670         


Pro Ile Ser Lys Tyr Val Val Glu Val Gln Val Ala Gly Gly Ala Gly 
        675                 680                 685             


Asp Pro Leu Trp Ile Asp Val Asp Arg Pro Glu Glu Thr Ser Thr Ile 
    690                 695                 700                 


Ile Arg Gly Leu Asn Ala Ser Thr Arg Tyr Leu Phe Arg Met Arg Ala 
705                 710                 715                 720 


Ser Ile Gln Gly Leu Gly Asp Trp Ser Asn Thr Val Glu Glu Ser Thr 
                725                 730                 735     


Leu Gly Asn Gly Leu Gln Ala Glu Gly Pro Val Gln Glu Ser Arg Ala 
            740                 745                 750         


Ala Glu Glu Gly Leu Asp Gln Gln Leu Ile Leu Ala Val Val Gly Ser 
        755                 760                 765             


Val Ser Ala Thr Cys Leu Thr Ile Leu Ala Ala Leu Leu Thr Leu Val 
    770                 775                 780                 


Cys Ile Arg Arg Ser Cys Leu His Arg Arg Arg Thr Phe Thr Tyr Gln 
785                 790                 795                 800 


Ser Gly Ser Gly Glu Glu Thr Ile Leu Gln Phe Ser Ser Gly Thr Leu 
                805                 810                 815     


Thr Leu Thr Arg Arg Pro Lys Leu Gln Pro Glu Pro Leu Ser Tyr Pro 
            820                 825                 830         


Val Leu Glu Trp Glu Asp Ile Thr Phe Glu Asp Leu Ile Gly Glu Gly 
        835                 840                 845             


Asn Phe Gly Gln Val Ile Arg Ala Met Ile Lys Lys Asp Gly Leu Lys 
    850                 855                 860                 


Met Asn Ala Ala Ile Lys Met Leu Lys Glu Tyr Ala Ser Glu Asn Asp 
865                 870                 875                 880 


His Arg Asp Phe Ala Gly Glu Leu Glu Val Leu Cys Lys Leu Gly His 
                885                 890                 895     


His Pro Asn Ile Ile Asn Leu Leu Gly Ala Cys Lys Asn Arg Gly Tyr 
            900                 905                 910         


Leu Tyr Ile Ala Ile Glu Tyr Ala Pro Tyr Gly Asn Leu Leu Asp Phe 
        915                 920                 925             


Leu Arg Lys Ser Arg Val Leu Glu Thr Asp Pro Ala Phe Ala Arg Glu 
    930                 935                 940                 


His Gly Thr Ala Ser Thr Leu Ser Ser Arg Gln Leu Leu Arg Phe Ala 
945                 950                 955                 960 


Ser Asp Ala Ala Asn Gly Met Gln Tyr Leu Ser Glu Lys Gln Phe Ile 
                965                 970                 975     


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Gly Glu Asn Leu Ala 
            980                 985                 990         


Ser Lys Ile Ala Asp Phe Gly Leu  Ser Arg Gly Glu Glu  Val Tyr Val 
        995                 1000                 1005             


Lys Lys  Thr Met Gly Arg Leu  Pro Val Arg Trp Met  Ala Ile Glu 
    1010                 1015                 1020             


Ser Leu  Asn Tyr Ser Val Tyr  Thr Thr Lys Ser Asp  Val Trp Ser 
    1025                 1030                 1035             


Phe Gly  Val Leu Leu Trp Glu  Ile Val Ser Leu Gly  Gly Thr Pro 
    1040                 1045                 1050             


Tyr Cys  Gly Met Thr Cys Ala  Glu Leu Tyr Glu Lys  Leu Pro Gln 
    1055                 1060                 1065             


Gly Tyr  Arg Met Glu Gln Pro  Arg Asn Cys Asp Asp  Glu Val Tyr 
    1070                 1075                 1080             


Glu Leu  Met Arg Gln Cys Trp  Arg Asp Arg Pro Tyr  Glu Arg Pro 
    1085                 1090                 1095             


Pro Phe  Ala Gln Ile Ala Leu  Gln Leu Gly Arg Met  Leu Glu Ala 
    1100                 1105                 1110             


Arg Lys  Ala Tyr Val Asn Met  Ser Leu Phe Glu Asn  Phe Thr Tyr 
    1115                 1120                 1125             


Ala Gly  Ile Asp Ala Thr Ala  Glu Glu Ala 
    1130                 1135             


<210>  467
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  467

Met Ala Leu Arg Arg Ser Met Gly Arg Pro Gly Leu Pro Pro Leu Pro 
1               5                   10                  15      


Leu Pro Pro Pro Pro Arg Leu Gly Leu Leu Leu Ala Ala Leu Ala Ser 
            20                  25                  30          


Leu Leu Leu Pro Glu Ser Ala Ala Ala Gly Leu Lys Leu Met Gly Ala 
        35                  40                  45              


Pro Val Lys Leu Thr Val Ser Gln Gly Gln Pro Val Lys Leu Asn Cys 
    50                  55                  60                  


Ser Val Glu Gly Met Glu Glu Pro Asp Ile Gln Trp Val Lys Asp Gly 
65                  70                  75                  80  


Ala Val Val Gln Asn Leu Asp Gln Leu Tyr Ile Pro Val Ser Glu Gln 
                85                  90                  95      


His Trp Ile Gly Phe Leu Ser Leu Lys Ser Val Glu Arg Ser Asp Ala 
            100                 105                 110         


Gly Arg Tyr Trp Cys Gln Val Glu Asp Gly Gly Glu Thr Glu Ile Ser 
        115                 120                 125             


Gln Pro Val Trp Leu Thr Val Glu Gly Val Pro Phe Phe Thr Val Glu 
    130                 135                 140                 


Pro Lys Asp Leu Ala Val Pro Pro Asn Ala Pro Phe Gln Leu Ser Cys 
145                 150                 155                 160 


Glu Ala Val Gly Pro Pro Glu Pro Val Thr Ile Val Trp Trp Arg Gly 
                165                 170                 175     


Thr Thr Lys Ile Gly Gly Pro Ala Pro Ser Pro Ser Val Leu Asn Val 
            180                 185                 190         


Thr Gly Val Thr Gln Ser Thr Met Phe Ser Cys Glu Ala His Asn Leu 
        195                 200                 205             


Lys Gly Leu Ala Ser Ser Arg Thr Ala Thr Val His Leu Gln Ala Leu 
    210                 215                 220                 


Pro Ala Ala Pro Phe Asn Ile Thr Val Thr Lys Leu Ser Ser Ser Asn 
225                 230                 235                 240 


Ala Ser Val Ala Trp Met Pro Gly Ala Asp Gly Arg Ala Leu Leu Gln 
                245                 250                 255     


Ser Cys Thr Val Gln Val Thr Gln Ala Pro Gly Gly Trp Glu Val Leu 
            260                 265                 270         


Ala Val Val Val Pro Val Pro Pro Phe Thr Cys Leu Leu Arg Asp Leu 
        275                 280                 285             


Val Pro Ala Thr Asn Tyr Ser Leu Arg Val Arg Cys Ala Asn Ala Leu 
    290                 295                 300                 


Gly Pro Ser Pro Tyr Ala Asp Trp Val Pro Phe Gln Thr Lys Gly Leu 
305                 310                 315                 320 


Ala Pro Ala Ser Ala Pro Gln Asn Leu His Ala Ile Arg Thr Asp Ser 
                325                 330                 335     


Gly Leu Ile Leu Glu Trp Glu Glu Val Ile Pro Glu Ala Pro Leu Glu 
            340                 345                 350         


Gly Pro Leu Gly Pro Tyr Lys Leu Ser Trp Val Gln Asp Asn Gly Thr 
        355                 360                 365             


Gln Asp Glu Leu Thr Val Glu Gly Thr Arg Ala Asn Leu Thr Gly Trp 
    370                 375                 380                 


Asp Pro Gln Lys Asp Leu Ile Val Arg Val Cys Val Ser Asn Ala Val 
385                 390                 395                 400 


Gly Cys Gly Pro Trp Ser Gln Pro Leu Val Val Ser Ser His Asp Arg 
                405                 410                 415     


Ala Gly Gln Gln Gly Pro Pro His Ser Arg Thr Ser Trp Val Pro Val 
            420                 425                 430         


Val Leu Gly Val Leu Thr Ala Leu Val Thr Ala Ala Ala Leu Ala Leu 
        435                 440                 445             


Ile Leu Leu Arg Lys Arg Arg Lys Glu Thr Arg Phe Gly Gln Ala Phe 
    450                 455                 460                 


Asp Ser Val Met Ala Arg Gly Glu Pro Ala Val His Phe Arg Ala Ala 
465                 470                 475                 480 


Arg Ser Phe Asn Arg Glu Arg Pro Glu Arg Ile Glu Ala Thr Leu Asp 
                485                 490                 495     


Ser Leu Gly Ile Ser Asp Glu Leu Lys Glu Lys Leu Glu Asp Val Leu 
            500                 505                 510         


Ile Pro Glu Gln Gln Phe Thr Leu Gly Arg Met Leu Gly Lys Gly Glu 
        515                 520                 525             


Phe Gly Ser Val Arg Glu Ala Gln Leu Lys Gln Glu Asp Gly Ser Phe 
    530                 535                 540                 


Val Lys Val Ala Val Lys Met Leu Lys Ala Asp Ile Ile Ala Ser Ser 
545                 550                 555                 560 


Asp Ile Glu Glu Phe Leu Arg Glu Ala Ala Cys Met Lys Glu Phe Asp 
                565                 570                 575     


His Pro His Val Ala Lys Leu Val Gly Val Ser Leu Arg Ser Arg Ala 
            580                 585                 590         


Lys Gly Arg Leu Pro Ile Pro Met Val Ile Leu Pro Phe Met Lys His 
        595                 600                 605             


Gly Asp Leu His Ala Phe Leu Leu Ala Ser Arg Ile Gly Glu Asn Pro 
    610                 615                 620                 


Phe Asn Leu Pro Leu Gln Thr Leu Ile Arg Phe Met Val Asp Ile Ala 
625                 630                 635                 640 


Cys Gly Met Glu Tyr Leu Ser Ser Arg Asn Phe Ile His Arg Asp Leu 
                645                 650                 655     


Ala Ala Arg Asn Cys Met Leu Ala Glu Asp Met Thr Val Cys Val Ala 
            660                 665                 670         


Asp Phe Gly Leu Ser Arg Lys Ile Tyr Ser Gly Asp Tyr Tyr Arg Gln 
        675                 680                 685             


Gly Cys Ala Ser Lys Leu Pro Val Lys Trp Leu Ala Leu Glu Ser Leu 
    690                 695                 700                 


Ala Asp Asn Leu Tyr Thr Val Gln Ser Asp Val Trp Ala Phe Gly Val 
705                 710                 715                 720 


Thr Met Trp Glu Ile Met Thr Arg Gly Gln Thr Pro Tyr Ala Gly Ile 
                725                 730                 735     


Glu Asn Ala Glu Ile Tyr Asn Tyr Leu Ile Gly Gly Asn Arg Leu Lys 
            740                 745                 750         


Gln Pro Pro Glu Cys Met Glu Asp Val Tyr Asp Leu Met Tyr Gln Cys 
        755                 760                 765             


Trp Ser Ala Asp Pro Lys Gln Arg Pro Ser Phe Thr Cys Leu Arg Met 
    770                 775                 780                 


Glu Leu Glu Asn Ile Leu Gly Gln Leu Ser Val Leu Ser Ala Ser Gln 
785                 790                 795                 800 


Asp Pro Leu Tyr Ile Asn Ile Glu Arg Ala Glu Glu Pro Thr Ala Gly 
                805                 810                 815     


Gly Ser Leu Glu Leu Pro Gly Arg Asp Gln Pro Tyr Ser Gly Ala Gly 
            820                 825                 830         


Asp Gly Ser Gly Met Gly Ala Val Gly Gly Thr Pro Ser Asp Cys Arg 
        835                 840                 845             


Tyr Ile Leu Thr Pro Gly Gly Leu Ala Glu Gln Pro Gly Gln Ala Glu 
    850                 855                 860                 


His Gln Pro Glu Ser Pro Leu Asn Glu Thr Gln Arg Leu Leu Leu Leu 
865                 870                 875                 880 


Gln Gln Gly Leu Leu Pro His Ser Ser Cys 
                885                 890 


<210>  468
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  468

Met Gly Pro Glu Ala Leu Ser Ser Leu Leu Leu Leu Leu Leu Val Ala 
1               5                   10                  15      


Ser Gly Asp Ala Asp Met Lys Gly His Phe Asp Pro Ala Lys Cys Arg 
            20                  25                  30          


Tyr Ala Leu Gly Met Gln Asp Arg Thr Ile Pro Asp Ser Asp Ile Ser 
        35                  40                  45              


Ala Ser Ser Ser Trp Ser Asp Ser Thr Ala Ala Arg His Ser Arg Leu 
    50                  55                  60                  


Glu Ser Ser Asp Gly Asp Gly Ala Trp Cys Pro Ala Gly Ser Val Phe 
65                  70                  75                  80  


Pro Lys Glu Glu Glu Tyr Leu Gln Val Asp Leu Gln Arg Leu His Leu 
                85                  90                  95      


Val Ala Leu Val Gly Thr Gln Gly Arg His Ala Gly Gly Leu Gly Lys 
            100                 105                 110         


Glu Phe Ser Arg Ser Tyr Arg Leu Arg Tyr Ser Arg Asp Gly Arg Arg 
        115                 120                 125             


Trp Met Gly Trp Lys Asp Arg Trp Gly Gln Glu Val Ile Ser Gly Asn 
    130                 135                 140                 


Glu Asp Pro Glu Gly Val Val Leu Lys Asp Leu Gly Pro Pro Met Val 
145                 150                 155                 160 


Ala Arg Leu Val Arg Phe Tyr Pro Arg Ala Asp Arg Val Met Ser Val 
                165                 170                 175     


Cys Leu Arg Val Glu Leu Tyr Gly Cys Leu Trp Arg Asp Gly Leu Leu 
            180                 185                 190         


Ser Tyr Thr Ala Pro Val Gly Gln Thr Met Tyr Leu Ser Glu Ala Val 
        195                 200                 205             


Tyr Leu Asn Asp Ser Thr Tyr Asp Gly His Thr Val Gly Gly Leu Gln 
    210                 215                 220                 


Tyr Gly Gly Leu Gly Gln Leu Ala Asp Gly Val Val Gly Leu Asp Asp 
225                 230                 235                 240 


Phe Arg Lys Ser Gln Glu Leu Arg Val Trp Pro Gly Tyr Asp Tyr Val 
                245                 250                 255     


Gly Trp Ser Asn His Ser Phe Ser Ser Gly Tyr Val Glu Met Glu Phe 
            260                 265                 270         


Glu Phe Asp Arg Leu Arg Ala Phe Gln Ala Met Gln Val His Cys Asn 
        275                 280                 285             


Asn Met His Thr Leu Gly Ala Arg Leu Pro Gly Gly Val Glu Cys Arg 
    290                 295                 300                 


Phe Arg Arg Gly Pro Ala Met Ala Trp Glu Gly Glu Pro Met Arg His 
305                 310                 315                 320 


Asn Leu Gly Gly Asn Leu Gly Asp Pro Arg Ala Arg Ala Val Ser Val 
                325                 330                 335     


Pro Leu Gly Gly Arg Val Ala Arg Phe Leu Gln Cys Arg Phe Leu Phe 
            340                 345                 350         


Ala Gly Pro Trp Leu Leu Phe Ser Glu Ile Ser Phe Ile Ser Asp Val 
        355                 360                 365             


Val Asn Asn Ser Ser Pro Ala Leu Gly Gly Thr Phe Pro Pro Ala Pro 
    370                 375                 380                 


Trp Trp Pro Pro Gly Pro Pro Pro Thr Asn Phe Ser Ser Leu Glu Leu 
385                 390                 395                 400 


Glu Pro Arg Gly Gln Gln Pro Val Ala Lys Ala Glu Gly Ser Pro Thr 
                405                 410                 415     


Ala Ile Leu Ile Gly Cys Leu Val Ala Ile Ile Leu Leu Leu Leu Leu 
            420                 425                 430         


Ile Ile Ala Leu Met Leu Trp Arg Leu His Trp Arg Arg Leu Leu Ser 
        435                 440                 445             


Lys Ala Glu Arg Arg Val Leu Glu Glu Glu Leu Thr Val His Leu Ser 
    450                 455                 460                 


Val Pro Gly Asp Thr Ile Leu Ile Asn Asn Arg Pro Gly Pro Arg Glu 
465                 470                 475                 480 


Pro Pro Pro Tyr Gln Glu Pro Arg Pro Arg Gly Asn Pro Pro His Ser 
                485                 490                 495     


Ala Pro Cys Val Pro Asn Gly Ser Ala Leu Leu Leu Ser Asn Pro Ala 
            500                 505                 510         


Tyr Arg Leu Leu Leu Ala Thr Tyr Ala Arg Pro Pro Arg Gly Pro Gly 
        515                 520                 525             


Pro Pro Thr Pro Ala Trp Ala Lys Pro Thr Asn Thr Gln Ala Tyr Ser 
    530                 535                 540                 


Gly Asp Tyr Met Glu Pro Glu Lys Pro Gly Ala Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Pro Pro Gln Asn Ser Val Pro His Tyr Ala Glu Ala Asp Ile Val Thr 
                565                 570                 575     


Leu Gln Gly Val Thr Gly Gly Asn Thr Tyr Ala Val Pro Ala Leu Pro 
            580                 585                 590         


Pro Gly Ala Val Gly Asp Gly Pro Pro Arg Val Asp Phe Pro Arg Ser 
        595                 600                 605             


Arg Leu Arg Phe Lys Glu Lys Leu Gly Glu Gly Gln Phe Gly Glu Val 
    610                 615                 620                 


His Leu Cys Glu Val Asp Ser Pro Gln Asp Leu Val Ser Leu Asp Phe 
625                 630                 635                 640 


Pro Leu Asn Val Arg Lys Gly His Pro Leu Leu Val Ala Val Lys Ile 
                645                 650                 655     


Leu Arg Pro Asp Ala Thr Lys Asn Ala Arg Asn Asp Phe Leu Lys Glu 
            660                 665                 670         


Val Lys Ile Met Ser Arg Leu Lys Asp Pro Asn Ile Ile Arg Leu Leu 
        675                 680                 685             


Gly Val Cys Val Gln Asp Asp Pro Leu Cys Met Ile Thr Asp Tyr Met 
    690                 695                 700                 


Glu Asn Gly Asp Leu Asn Gln Phe Leu Ser Ala His Gln Leu Glu Asp 
705                 710                 715                 720 


Lys Ala Ala Glu Gly Ala Pro Gly Asp Gly Gln Ala Ala Gln Gly Pro 
                725                 730                 735     


Thr Ile Ser Tyr Pro Met Leu Leu His Val Ala Ala Gln Ile Ala Ser 
            740                 745                 750         


Gly Met Arg Tyr Leu Ala Thr Leu Asn Phe Val His Arg Asp Leu Ala 
        755                 760                 765             


Thr Arg Asn Cys Leu Val Gly Glu Asn Phe Thr Ile Lys Ile Ala Asp 
    770                 775                 780                 


Phe Gly Met Ser Arg Asn Leu Tyr Ala Gly Asp Tyr Tyr Arg Val Gln 
785                 790                 795                 800 


Gly Arg Ala Val Leu Pro Ile Arg Trp Met Ala Trp Glu Cys Ile Leu 
                805                 810                 815     


Met Gly Lys Phe Thr Thr Ala Ser Asp Val Trp Ala Phe Gly Val Thr 
            820                 825                 830         


Leu Trp Glu Val Leu Met Leu Cys Arg Ala Gln Pro Phe Gly Gln Leu 
        835                 840                 845             


Thr Asp Glu Gln Val Ile Glu Asn Ala Gly Glu Phe Phe Arg Asp Gln 
    850                 855                 860                 


Gly Arg Gln Val Tyr Leu Ser Arg Pro Pro Ala Cys Pro Gln Gly Leu 
865                 870                 875                 880 


Tyr Glu Leu Met Leu Arg Cys Trp Ser Arg Glu Ser Glu Gln Arg Pro 
                885                 890                 895     


Pro Phe Ser Gln Leu His Arg Phe Leu Ala Glu Asp Ala Leu Asn Thr 
            900                 905                 910         


Val 
    


<210>  469
<211>  1374
<212>  PRT
<213>  Homo sapiens

<400>  469

Met Ser Ser Ser Phe Phe Asn Pro Ser Phe Ala Phe Ser Ser His Phe 
1               5                   10                  15      


Asp Pro Asp Gly Ala Pro Leu Ser Glu Leu Ser Trp Pro Ser Ser Leu 
            20                  25                  30          


Ala Val Val Ala Val Ser Phe Ser Gly Leu Phe Ala Val Ile Val Leu 
        35                  40                  45              


Met Leu Ala Cys Leu Cys Cys Lys Lys Gly Gly Ile Gly Phe Lys Glu 
    50                  55                  60                  


Phe Glu Asn Ala Glu Gly Asp Glu Tyr Ala Ala Asp Leu Ala Gln Gly 
65                  70                  75                  80  


Ser Pro Ala Thr Ala Ala Gln Asn Gly Pro Asp Val Tyr Val Leu Pro 
                85                  90                  95      


Leu Thr Glu Val Ser Leu Pro Met Ala Lys Gln Pro Gly Arg Ser Val 
            100                 105                 110         


Gln Leu Leu Lys Ser Thr Asp Val Gly Arg His Ser Leu Leu Tyr Leu 
        115                 120                 125             


Lys Glu Ile Gly Arg Gly Trp Phe Gly Lys Val Phe Leu Gly Glu Val 
    130                 135                 140                 


Asn Ser Gly Ile Ser Ser Ala Gln Val Val Val Lys Glu Leu Gln Ala 
145                 150                 155                 160 


Ser Ala Ser Val Gln Glu Gln Met Gln Phe Leu Glu Glu Val Gln Pro 
                165                 170                 175     


Tyr Arg Ala Leu Lys His Ser Asn Leu Leu Gln Cys Leu Ala Gln Cys 
            180                 185                 190         


Ala Glu Val Thr Pro Tyr Leu Leu Val Met Glu Phe Cys Pro Leu Gly 
        195                 200                 205             


Asp Leu Lys Gly Tyr Leu Arg Ser Cys Arg Val Ala Glu Ser Met Ala 
    210                 215                 220                 


Pro Asp Pro Arg Thr Leu Gln Arg Met Ala Cys Glu Val Ala Cys Gly 
225                 230                 235                 240 


Val Leu His Leu His Arg Asn Asn Phe Val His Ser Asp Leu Ala Leu 
                245                 250                 255     


Arg Asn Cys Leu Leu Thr Ala Asp Leu Thr Val Lys Ile Gly Asp Tyr 
            260                 265                 270         


Gly Leu Ala His Cys Lys Tyr Arg Glu Asp Tyr Phe Val Thr Ala Asp 
        275                 280                 285             


Gln Leu Trp Val Pro Leu Arg Trp Ile Ala Pro Glu Leu Val Asp Glu 
    290                 295                 300                 


Val His Ser Asn Leu Leu Val Val Asp Gln Thr Lys Ser Gly Asn Val 
305                 310                 315                 320 


Trp Ser Leu Gly Val Thr Ile Trp Glu Leu Phe Glu Leu Gly Thr Gln 
                325                 330                 335     


Pro Tyr Pro Gln His Ser Asp Gln Gln Val Leu Ala Tyr Thr Val Arg 
            340                 345                 350         


Glu Gln Gln Leu Lys Leu Pro Lys Pro Gln Leu Gln Leu Thr Leu Ser 
        355                 360                 365             


Asp Arg Trp Tyr Glu Val Met Gln Phe Cys Trp Leu Gln Pro Glu Gln 
    370                 375                 380                 


Arg Pro Thr Ala Glu Glu Val His Leu Leu Leu Ser Tyr Leu Cys Ala 
385                 390                 395                 400 


Lys Gly Ala Thr Glu Ala Glu Glu Glu Phe Glu Arg Arg Trp Arg Ser 
                405                 410                 415     


Leu Arg Pro Gly Gly Gly Gly Val Gly Pro Gly Pro Gly Ala Ala Gly 
            420                 425                 430         


Pro Met Leu Gly Gly Val Val Glu Leu Ala Ala Ala Ser Ser Phe Pro 
        435                 440                 445             


Leu Leu Glu Gln Phe Ala Gly Asp Gly Phe His Ala Asp Gly Asp Asp 
    450                 455                 460                 


Val Leu Thr Val Thr Glu Thr Ser Arg Gly Leu Asn Phe Glu Tyr Lys 
465                 470                 475                 480 


Trp Glu Ala Gly Arg Gly Ala Glu Ala Phe Pro Ala Thr Leu Ser Pro 
                485                 490                 495     


Gly Arg Thr Ala Arg Leu Gln Glu Leu Cys Ala Pro Asp Gly Ala Pro 
            500                 505                 510         


Pro Gly Val Val Pro Val Leu Ser Ala His Ser Pro Ser Leu Gly Ser 
        515                 520                 525             


Glu Tyr Phe Ile Arg Leu Glu Glu Ala Ala Pro Ala Ala Gly His Asp 
    530                 535                 540                 


Pro Asp Cys Ala Gly Cys Ala Pro Ser Pro Pro Ala Thr Ala Asp Gln 
545                 550                 555                 560 


Asp Asp Asp Ser Asp Gly Ser Thr Ala Ala Ser Leu Ala Met Glu Pro 
                565                 570                 575     


Leu Leu Gly His Gly Pro Pro Val Asp Val Pro Trp Gly Arg Gly Asp 
            580                 585                 590         


His Tyr Pro Arg Arg Ser Leu Ala Arg Asp Pro Leu Cys Pro Ser Arg 
        595                 600                 605             


Ser Pro Ser Pro Ser Ala Gly Pro Leu Ser Leu Ala Glu Gly Gly Ala 
    610                 615                 620                 


Glu Asp Ala Asp Trp Gly Val Ala Ala Phe Cys Pro Ala Phe Phe Glu 
625                 630                 635                 640 


Asp Pro Leu Gly Thr Ser Pro Leu Gly Ser Ser Gly Ala Pro Pro Leu 
                645                 650                 655     


Pro Leu Thr Gly Glu Asp Glu Leu Glu Glu Val Gly Ala Arg Arg Ala 
            660                 665                 670         


Ala Gln Arg Gly His Trp Arg Ser Asn Val Ser Ala Asn Asn Asn Ser 
        675                 680                 685             


Gly Ser Arg Cys Pro Glu Ser Trp Asp Pro Val Ser Ala Gly Gly His 
    690                 695                 700                 


Ala Glu Gly Cys Pro Ser Pro Lys Gln Thr Pro Arg Ala Ser Pro Glu 
705                 710                 715                 720 


Pro Gly Tyr Pro Gly Glu Pro Leu Leu Gly Leu Gln Ala Ala Ser Ala 
                725                 730                 735     


Gln Glu Pro Gly Cys Cys Pro Gly Leu Pro His Leu Cys Ser Ala Gln 
            740                 745                 750         


Gly Leu Ala Pro Ala Pro Cys Leu Val Thr Pro Ser Trp Thr Glu Thr 
        755                 760                 765             


Ala Ser Ser Gly Gly Asp His Pro Gln Ala Glu Pro Lys Leu Ala Thr 
    770                 775                 780                 


Glu Ala Glu Gly Thr Thr Gly Pro Arg Leu Pro Leu Pro Ser Val Pro 
785                 790                 795                 800 


Ser Pro Ser Gln Glu Gly Ala Pro Leu Pro Ser Glu Glu Ala Ser Ala 
                805                 810                 815     


Pro Asp Ala Pro Asp Ala Leu Pro Asp Ser Pro Thr Pro Ala Thr Gly 
            820                 825                 830         


Gly Glu Val Ser Ala Ile Lys Leu Ala Ser Ala Leu Asn Gly Ser Ser 
        835                 840                 845             


Ser Ser Pro Glu Val Glu Ala Pro Ser Ser Glu Asp Glu Asp Thr Ala 
    850                 855                 860                 


Glu Ala Thr Ser Gly Ile Phe Thr Asp Thr Ser Ser Asp Gly Leu Gln 
865                 870                 875                 880 


Ala Arg Arg Pro Asp Val Val Pro Ala Phe Arg Ser Leu Gln Lys Gln 
                885                 890                 895     


Val Gly Thr Pro Asp Ser Leu Asp Ser Leu Asp Ile Pro Ser Ser Ala 
            900                 905                 910         


Ser Asp Gly Gly Tyr Glu Val Phe Ser Pro Ser Ala Thr Gly Pro Ser 
        915                 920                 925             


Gly Gly Gln Pro Arg Ala Leu Asp Ser Gly Tyr Asp Thr Glu Asn Tyr 
    930                 935                 940                 


Glu Ser Pro Glu Phe Val Leu Lys Glu Ala Gln Glu Gly Cys Glu Pro 
945                 950                 955                 960 


Gln Ala Phe Ala Glu Leu Ala Ser Glu Gly Glu Gly Pro Gly Pro Glu 
                965                 970                 975     


Thr Arg Leu Ser Thr Ser Leu Ser Gly Leu Asn Glu Lys Asn Pro Tyr 
            980                 985                 990         


Arg Asp Ser Ala Tyr Phe Ser Asp  Leu Glu Ala Glu Ala  Glu Ala Thr 
        995                 1000                 1005             


Ser Gly  Pro Glu Lys Lys Cys  Gly Gly Asp Arg Ala  Pro Gly Pro 
    1010                 1015                 1020             


Glu Leu  Gly Leu Pro Ser Thr  Gly Gln Pro Ser Glu  Gln Val Cys 
    1025                 1030                 1035             


Leu Arg  Pro Gly Val Ser Gly  Glu Ala Gln Gly Ser  Gly Pro Gly 
    1040                 1045                 1050             


Glu Val  Leu Pro Pro Leu Leu  Gln Leu Glu Gly Ser  Ser Pro Glu 
    1055                 1060                 1065             


Pro Ser  Thr Cys Pro Ser Gly  Leu Val Pro Glu Pro  Pro Glu Pro 
    1070                 1075                 1080             


Gln Gly  Pro Ala Lys Val Arg  Pro Gly Pro Ser Pro  Ser Cys Ser 
    1085                 1090                 1095             


Gln Phe  Phe Leu Leu Thr Pro  Val Pro Leu Arg Ser  Glu Gly Asn 
    1100                 1105                 1110             


Ser Ser  Glu Phe Gln Gly Pro  Pro Gly Leu Leu Ser  Gly Pro Ala 
    1115                 1120                 1125             


Pro Gln  Lys Arg Met Gly Gly  Pro Gly Thr Pro Arg  Ala Pro Leu 
    1130                 1135                 1140             


Arg Leu  Ala Leu Pro Gly Leu  Pro Ala Ala Leu Glu  Gly Arg Pro 
    1145                 1150                 1155             


Glu Glu  Glu Glu Glu Asp Ser  Glu Asp Ser Asp Glu  Ser Asp Glu 
    1160                 1165                 1170             


Glu Leu  Arg Cys Tyr Ser Val  Gln Glu Pro Ser Glu  Asp Ser Glu 
    1175                 1180                 1185             


Glu Glu  Ala Pro Ala Val Pro  Val Val Val Ala Glu  Ser Gln Ser 
    1190                 1195                 1200             


Ala Arg  Asn Leu Arg Ser Leu  Leu Lys Met Pro Ser  Leu Leu Ser 
    1205                 1210                 1215             


Glu Thr  Phe Cys Glu Asp Leu  Glu Arg Lys Lys Lys  Ala Val Ser 
    1220                 1225                 1230             


Phe Phe  Asp Asp Val Thr Val  Tyr Leu Phe Asp Gln  Glu Ser Pro 
    1235                 1240                 1245             


Thr Arg  Glu Leu Gly Glu Pro  Phe Pro Gly Ala Lys  Glu Ser Pro 
    1250                 1255                 1260             


Pro Thr  Phe Leu Arg Gly Ser  Pro Gly Ser Pro Ser  Ala Pro Asn 
    1265                 1270                 1275             


Arg Pro  Gln Gln Ala Asp Gly  Ser Pro Asn Gly Ser  Thr Ala Glu 
    1280                 1285                 1290             


Glu Gly  Gly Gly Phe Ala Trp  Asp Asp Asp Phe Pro  Leu Met Thr 
    1295                 1300                 1305             


Ala Lys  Ala Ala Phe Ala Met  Ala Leu Asp Pro Ala  Ala Pro Ala 
    1310                 1315                 1320             


Pro Ala  Ala Pro Thr Pro Thr  Pro Ala Pro Phe Ser  Arg Phe Thr 
    1325                 1330                 1335             


Val Ser  Pro Ala Pro Thr Ser  Arg Phe Ser Ile Thr  His Val Ser 
    1340                 1345                 1350             


Asp Ser  Asp Ala Glu Ser Lys  Arg Gly Pro Glu Ala  Gly Ala Gly 
    1355                 1360                 1365             


Gly Glu  Ser Lys Glu Ala 
    1370                 


<210>  470
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  470

Arg Met Phe Pro Asn Ala Pro Tyr Leu 
1               5                   


<210>  471
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  471

Lys Leu Val Val Val Gly Ala Gly Gly Val 
1               5                   10  


<210>  472
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  472

Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10  


<210>  473
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  473

Lys Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   10  


<210>  474
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  474

Lys Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  475
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  475

Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   


<210>  476
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  476

Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   


<210>  477
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  477

Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   


<210>  478
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  478

Lys Ile Thr Asp Phe Gly Leu Ala Lys 
1               5                   


<210>  479
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  479

Lys Ile Thr Asp Phe Gly Arg Ala Lys 
1               5                   


<210>  480
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  480

Val Leu Gln Glu Leu Asn Val Thr Val 
1               5                   


<210>  481
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  481

Glu Ala Asp Pro Thr Gly His Ser Tyr 
1               5                   


<210>  482
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  482

Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   


<210>  483
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  483

Ser Thr Thr Pro Pro Pro Gly Thr Arg Val 
1               5                   10  


<210>  484
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  484

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  485
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  485

Ile Met Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  486
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  486

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  487
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  487

Ala Ile Ile Arg Ile Leu Gln Gln Leu 
1               5                   


<210>  488
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  488

Val Leu His Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  489
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  489

Val Leu Arg Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  490
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  490

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  491
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  491

Leu Leu Asp Phe Val Arg Phe Met Gly Val 
1               5                   10  


<210>  492
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  492

Phe Met Asn Lys Phe Ile Tyr Glu Ile 
1               5                   


<210>  493
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  493

Lys Ile Phe Gly Ser Leu Ala Phe Leu 
1               5                   


<210>  494
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  494

Gly Val Leu Pro Ala Leu Pro Gln Val 
1               5                   


<210>  495
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  495

Phe Leu Leu Thr Arg Ile Leu Thr Ile 
1               5                   


<210>  496
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  496

His Leu Ser Pro Ile Asp Cys Glu Val 
1               5                   


<210>  497
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  497

Leu Thr Ser Met Trp Ser Pro Ala Val 
1               5                   


<210>  498
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  498

His Leu Asp His Pro His Pro Ala Val 
1               5                   


<210>  499
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  499

Ser Leu Ser Val Met Ser Ser Asn Val 
1               5                   


<210>  500
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  500

Met Met Ala Trp Ser Asp Asn Lys Ile 
1               5                   


<210>  501
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  501

Thr Gln Ile Gly Ile Glu Trp Asn Leu 
1               5                   


<210>  502
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  502

Cys Leu Phe Glu Met Gln Asp Pro Ala 
1               5                   


<210>  503
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  503

Tyr Leu Ser His Pro Ser Cys Asn Val 
1               5                   


<210>  504
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  504

Gly Ile Glu Trp Asn Leu Ser Pro Val 
1               5                   


<210>  505
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  505

Gly Leu Gly Cys Ser Pro Ala Ser Ile 
1               5                   


<210>  506
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  506

Arg Gln Ala Phe Glu Phe Pro Gln Ile 
1               5                   


<210>  507
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  507

Arg Gln Ala Phe Glu Phe Pro Gln Ile 
1               5                   


<210>  508
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  508

Gly Met Trp Thr Asp Thr Phe Glu Phe 
1               5                   


<210>  509
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  509

Tyr Leu Asn Trp Gln Asp Thr Ala Val 
1               5                   


<210>  510
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  510

Val Leu Trp Gly Pro Ile Thr Gln Ile 
1               5                   


<210>  511
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  511

Thr Leu Asp His Thr Gly Val Val Val 
1               5                   


<210>  512
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  512

Thr Met Gly Val Trp Leu His Ile Ala 
1               5                   


<210>  513
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  513

Thr Met Gly Val Trp Leu His Ile Ala 
1               5                   


<210>  514
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  514

Lys Val Trp Val Gln Gly His Tyr Leu 
1               5                   


<210>  515
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  515

Lys Ile Asn Cys Asn Asn Phe Arg Leu 
1               5                   


<210>  516
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  516

Gly Ser Gly Gly Ser 
1               5   


<210>  517
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  517

Gly Gly Gly Ser 
1               


<210>  518
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  518

Gly Gly Ser Gly 
1               


<210>  519
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  519

Gly Gly Ser Gly Gly 
1               5   


<210>  520
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  520

Gly Ser Gly Ser Gly 
1               5   


<210>  521
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  521

Gly Ser Gly Gly Gly 
1               5   


<210>  522
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  522

Gly Gly Gly Ser Gly 
1               5   


<210>  523
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  523

Gly Ser Ser Ser Gly 
1               5   


<210>  524
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  524

Asp Lys Thr His Thr 
1               5   


<210>  525
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  525

Cys Pro Pro Cys 
1               


<210>  526
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  526

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  527
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  527

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  528
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  528

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  529
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  529

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  530
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  530

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  531
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  531

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  532
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  532

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  533
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  533

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  534
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  534

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  535
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  535

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  536
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  536

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  537
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  537

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  538
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  538

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  539
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  539

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  540
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  540

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  541
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  541

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  542
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  542

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  543
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  543

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  544
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  544

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  545
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  545

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  546
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  546

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  547
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  547

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  548
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  548

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  549
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  549

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  550
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  550

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  551
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  551

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  552
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  552

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  553
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  553

Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu 
1               5                   10                  15      


Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly 
            20                  25                  30          


Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His 
        35                  40                  45              


Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln 
    50                  55                  60                  


Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val 
                85                  90                  95      


Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu 
            100                 105                 110         


Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu 
        115                 120                 125             


Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr 
    130                 135                 140                 


Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys 
145                 150                 155                 160 


Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala 
                165                 170                 175     


Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser 
            180                 185                 190         


Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln 
        195                 200             


<210>  554
<211>  78
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  554

Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu 
1               5                   10                  15      


Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu 
            20                  25                  30          


Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn 
        35                  40                  45              


Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala 
    50                  55                  60                  


Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala 
65                  70                  75              


<210>  555
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  555

Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val Ser 
1               5                   10                  15      


Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
            20                  25                  30          


Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu Arg 
        35                  40                  45              


Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala Met 
    50                  55                  60                  


Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn Ser 
                85                  90                  95      


Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala Gly 
            100                 105                 110         


Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr Ala 
        115                 120                 125             


Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu Arg 
    130                 135                 140                 


Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly Arg 
145                 150                 155                 160 


Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser Pro 
                165                 170                 175     


Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr Ser 
            180                 185                 190         


Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly Asn 
        195                 200                 205             


Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser Ala 
    210                 215                 220                 


Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser Ala 
225                 230                 235                 240 


Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro Val 
                245                 250                 255     


Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg Pro 
            260                 265                 270         


Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met Asn 
        275                 280                 285             


Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    290                 295                 300     


<210>  556
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  556

Asn Tyr Gly Thr Asn Pro Gly Thr Pro Pro Ala Ser Thr Ser Pro Phe 
1               5                   10                  15      


Ser Gln Leu Ala Ala Asn Pro Glu Ala Ser Leu Ala Asn Arg Asn Ser 
            20                  25                  30          


Met Val Ser Arg Gly Met Thr Gly Asn Ile Gly Gly Gln Phe Gly Thr 
        35                  40                  45              


Gly Ile Asn Pro Gln Met Gln Gln Asn Val Phe Gln Tyr Pro Gly Ala 
    50                  55                  60                  


Gly Met Val Pro Gln Gly Glu Ala Asn Phe Ala Pro Ser Leu Ser Pro 
65                  70                  75                  80  


Gly Ser Ser Met Val Pro Met Pro Ile Pro Pro Pro Gln Ser Ser Leu 
                85                  90                  95      


Leu Gln Gln Thr Pro Pro Ala Ser Gly Tyr Gln Ser Pro Asp Met Lys 
            100                 105                 110         


Ala Trp Gln Gln Gly Ala Ile Gly Asn Asn Asn Val Phe Ser Gln Ala 
        115                 120                 125             


Val Gln Asn Gln Pro Thr Pro Ala Gln Pro Gly Val Tyr Asn Asn Met 
    130                 135                 140                 


Ser Ile Thr Val Ser Met Ala Gly Gly Asn Thr Asn Val Gln Asn Met 
145                 150                 155                 160 


Asn Pro Met Met Ala Gln Met Gln Met Ser Ser Leu Gln Met Pro Gly 
                165                 170                 175     


Met Asn Thr Val Cys Pro Glu Gln Ile Asn Asp Pro Ala Leu Arg His 
            180                 185                 190         


Thr Gly Leu Tyr Cys Asn Gln Leu Ser Ser Thr Asp Leu Leu Lys Thr 
        195                 200                 205             


Glu Ala Asp Gly Thr Gln Gln Val Gln Gln Val Gln Val Phe Ala Asp 
    210                 215                 220                 


Val Gln Cys Thr Val Asn Leu Val Gly Gly Asp Pro Tyr Leu Asn Gln 
225                 230                 235                 240 


Pro Gly Pro Leu Gly Thr Gln Lys Pro Thr Ser Gly Pro Gln Thr Pro 
                245                 250                 255     


Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
            260                 265                 270 


<210>  557
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  557

Lys Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln 
1               5                   10                  15      


Ile Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr 
            20                  25                  30          


Lys Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val 
        35                  40                  45              


Ile Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn 
    50                  55                  60                  


Pro Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser 
65                  70                  75                  80  


Ser Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln 
                85                  90                  95      


Asp Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys 
            100                 105                 110         


Glu Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met 
        115                 120                 125             


Asn His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr 
    130                 135                 140                 


Ala Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro 
145                 150                 155                 160 


Gly Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly 
                165                 170                 175     


Val Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly 
            180                 185                 190         


Ser Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His 
        195                 200                 205             


Ser Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly 
    210                 215                 220                 


His Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met 
225                 230                 235                 240 


Gly Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser 
                245                 250                 255     


Lys Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu 
            260                 265                 270         


Pro Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly 
        275                 280                 285             


Glu Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser 
    290                 295                 300                 


Glu Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr 
305                 310                 315                 320 


Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser 
                325                 330                 335     


Pro Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser 
            340                 345                 350         


Leu Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His 
        355                 360                 365             


Lys Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu 
    370                 375                 380                 


Ala Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser 
385                 390                 395                 400 


Ser Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val 
                405                 410                 415     


Ser Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys 
            420                 425                 430         


Asp Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu 
        435                 440                 445             


Arg Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala 
    450                 455                 460                 


Met Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro 
465                 470                 475                 480 


Gly Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn 
                485                 490                 495     


Ser Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala 
            500                 505                 510         


Gly Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr 
        515                 520                 525             


Ala Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu 
    530                 535                 540                 


Arg Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly 
545                 550                 555                 560 


Arg Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser 
                565                 570                 575     


Pro Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr 
            580                 585                 590         


Ser Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly 
        595                 600                 605             


Asn Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser 
    610                 615                 620                 


Ala Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser 
625                 630                 635                 640 


Ala Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro 
                645                 650                 655     


Val Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg 
            660                 665                 670         


Pro Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met 
        675                 680                 685             


Asn Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    690                 695                 700         


<210>  558
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  558

Asn Tyr Gly Thr Asn Pro Gly Thr Pro Pro Ala Ser Thr Ser Pro Phe 
1               5                   10                  15      


Ser Gln Leu Ala Ala Asn Pro Glu Ala Ser Leu Ala Asn Arg Asn Ser 
            20                  25                  30          


Met Val Ser Arg Gly Met Thr Gly Asn Ile Gly Gly Gln Phe Gly Thr 
        35                  40                  45              


Gly Ile Asn Pro Gln Met Gln Gln Asn Val Phe Gln Tyr Pro Gly Ala 
    50                  55                  60                  


Gly Met Val Pro Gln Gly Glu Ala Asn Phe Ala Pro Ser Leu Ser Pro 
65                  70                  75                  80  


Gly Ser Ser Met Val Pro Met Pro Ile Pro Pro Pro Gln Ser Ser Leu 
                85                  90                  95      


Leu Gln Gln Thr Pro Pro Ala Ser Gly Tyr Gln Ser Pro Asp Met Lys 
            100                 105                 110         


Ala Trp Gln Gln Gly Ala Ile Gly Asn Asn Asn Val Phe Ser Gln Ala 
        115                 120                 125             


Val Gln Asn Gln Pro Thr Pro Ala Gln Pro Gly Val Tyr Asn Asn Met 
    130                 135                 140                 


Ser Ile Thr Val Ser Met Ala Gly Gly Asn Thr Asn Val Gln Asn Met 
145                 150                 155                 160 


Asn Pro Met Met Ala Gln Met Gln Met Ser Ser Leu Gln Met Pro Gly 
                165                 170                 175     


Met Asn Thr Val Cys Pro Glu Gln Ile Asn Asp Pro Ala Leu Arg His 
            180                 185                 190         


Thr Gly Leu Tyr Cys Asn Gln Leu Ser Ser Thr Asp Leu Leu Lys Thr 
        195                 200                 205             


Glu Ala Asp Gly Thr Gln Gln Val Gln Gln Val Gln Val Phe Ala Asp 
    210                 215                 220                 


Val Gln Cys Thr Val Asn Leu Val Gly Gly Asp Pro Tyr Leu Asn Gln 
225                 230                 235                 240 


Pro Gly Pro Leu Gly Thr Gln Lys Pro Thr Ser Gly Pro Gln Thr Pro 
                245                 250                 255     


Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
            260                 265                 270 


<210>  559
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  559

Lys Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln 
1               5                   10                  15      


Ile Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr 
            20                  25                  30          


Lys Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val 
        35                  40                  45              


Ile Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn 
    50                  55                  60                  


Pro Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser 
65                  70                  75                  80  


Ser Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln 
                85                  90                  95      


Asp Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys 
            100                 105                 110         


Glu Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met 
        115                 120                 125             


Asn His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr 
    130                 135                 140                 


Ala Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro 
145                 150                 155                 160 


Gly Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly 
                165                 170                 175     


Val Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly 
            180                 185                 190         


Ser Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His 
        195                 200                 205             


Ser Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly 
    210                 215                 220                 


His Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met 
225                 230                 235                 240 


Gly Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser 
                245                 250                 255     


Lys Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu 
            260                 265                 270         


Pro Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly 
        275                 280                 285             


Glu Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser 
    290                 295                 300                 


Glu Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr 
305                 310                 315                 320 


Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser 
                325                 330                 335     


Pro Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser 
            340                 345                 350         


Leu Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His 
        355                 360                 365             


Lys Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu 
    370                 375                 380                 


Ala Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser 
385                 390                 395                 400 


Ser Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val 
                405                 410                 415     


Ser Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys 
            420                 425                 430         


Asp Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu 
        435                 440                 445             


Arg Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala 
    450                 455                 460                 


Met Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro 
465                 470                 475                 480 


Gly Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn 
                485                 490                 495     


Ser Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala 
            500                 505                 510         


Gly Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr 
        515                 520                 525             


Ala Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu 
    530                 535                 540                 


Arg Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly 
545                 550                 555                 560 


Arg Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser 
                565                 570                 575     


Pro Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr 
            580                 585                 590         


Ser Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly 
        595                 600                 605             


Asn Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser 
    610                 615                 620                 


Ala Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser 
625                 630                 635                 640 


Ala Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro 
                645                 650                 655     


Val Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg 
            660                 665                 670         


Pro Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met 
        675                 680                 685             


Asn Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    690                 695                 700         


<210>  560
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  560

Leu Leu Arg Tyr Leu Leu Asp Lys 
1               5               


<210>  561
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  561

Asn Tyr Gly Thr Asn Pro Gly Thr Pro Pro Ala Ser Thr Ser Pro Phe 
1               5                   10                  15      


Ser Gln Leu Ala Ala Asn Pro Glu Ala Ser Leu Ala Asn Arg Asn Ser 
            20                  25                  30          


Met Val Ser Arg Gly Met Thr Gly Asn Ile Gly Gly Gln Phe Gly Thr 
        35                  40                  45              


Gly Ile Asn Pro Gln Met Gln Gln Asn Val Phe Gln Tyr Pro Gly Ala 
    50                  55                  60                  


Gly Met Val Pro Gln Gly Glu Ala Asn Phe Ala Pro Ser Leu Ser Pro 
65                  70                  75                  80  


Gly Ser Ser Met Val Pro Met Pro Ile Pro Pro Pro Gln Ser Ser Leu 
                85                  90                  95      


Leu Gln Gln Thr Pro Pro Ala Ser Gly Tyr Gln Ser Pro Asp Met Lys 
            100                 105                 110         


Ala Trp Gln Gln Gly Ala Ile Gly Asn Asn Asn Val Phe Ser Gln Ala 
        115                 120                 125             


Val Gln Asn Gln Pro Thr Pro Ala Gln Pro Gly Val Tyr Asn Asn Met 
    130                 135                 140                 


Ser Ile Thr Val Ser Met Ala Gly Gly Asn Thr Asn Val Gln Asn Met 
145                 150                 155                 160 


Asn Pro Met Met Ala Gln Met Gln Met Ser Ser Leu Gln Met Pro Gly 
                165                 170                 175     


Met Asn Thr Val Cys Pro Glu Gln Ile Asn Asp Pro Ala Leu Arg His 
            180                 185                 190         


Thr Gly Leu Tyr Cys Asn Gln Leu Ser Ser Thr Asp Leu Leu Lys Thr 
        195                 200                 205             


Glu Ala Asp Gly Thr Gln Gln Val Gln Gln Val Gln Val Phe Ala Asp 
    210                 215                 220                 


Val Gln Cys Thr Val Asn Leu Val Gly Gly Asp Pro Tyr Leu Asn Gln 
225                 230                 235                 240 


Pro Gly Pro Leu Gly Thr Gln Lys Pro Thr Ser Gly Pro Gln Thr Pro 
                245                 250                 255     


Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
            260                 265                 270 


<210>  562
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  562

Lys Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln 
1               5                   10                  15      


Ile Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr 
            20                  25                  30          


Lys Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val 
        35                  40                  45              


Ile Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn 
    50                  55                  60                  


Pro Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser 
65                  70                  75                  80  


Ser Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln 
                85                  90                  95      


Asp Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys 
            100                 105                 110         


Glu Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met 
        115                 120                 125             


Asn His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr 
    130                 135                 140                 


Ala Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro 
145                 150                 155                 160 


Gly Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly 
                165                 170                 175     


Val Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly 
            180                 185                 190         


Ser Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His 
        195                 200                 205             


Ser Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly 
    210                 215                 220                 


His Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met 
225                 230                 235                 240 


Gly Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser 
                245                 250                 255     


Lys Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu 
            260                 265                 270         


Pro Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly 
        275                 280                 285             


Glu Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser 
    290                 295                 300                 


Glu Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr 
305                 310                 315                 320 


Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser 
                325                 330                 335     


Pro Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser 
            340                 345                 350         


Leu Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His 
        355                 360                 365             


Lys Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu 
    370                 375                 380                 


Ala Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser 
385                 390                 395                 400 


Ser Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val 
                405                 410                 415     


Ser Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys 
            420                 425                 430         


Asp Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu 
        435                 440                 445             


Arg Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala 
    450                 455                 460                 


Met Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro 
465                 470                 475                 480 


Gly Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn 
                485                 490                 495     


Ser Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala 
            500                 505                 510         


Gly Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr 
        515                 520                 525             


Ala Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu 
    530                 535                 540                 


Arg Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly 
545                 550                 555                 560 


Arg Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser 
                565                 570                 575     


Pro Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr 
            580                 585                 590         


Ser Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly 
        595                 600                 605             


Asn Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser 
    610                 615                 620                 


Ala Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser 
625                 630                 635                 640 


Ala Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro 
                645                 650                 655     


Val Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg 
            660                 665                 670         


Pro Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met 
        675                 680                 685             


Asn Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    690                 695                 700         


<210>  563
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  563

Cys Asp Pro Ala Ser Asn Leu Gly Leu Glu Asp Ile Ile Arg Lys Ala 
1               5                   10                  15      


Leu Met Gly Ser Phe Asp Asp Lys 
            20                  


<210>  564
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  the amino acid at this position may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid at this position may be L or I

<400>  564

Tyr Xaa Xaa Xaa 
1               


<210>  565
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  the amino acid at this position may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  the amino acid at this position may be a L or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(12)
<223>  6-8 amino acids may be present at these positions and, when 
       present, the amino acids may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(15)
<223>  the amino acid at this position may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  the amino acid at this position may be a L or I

<400>  565

Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15      


<210>  566
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  566

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  567
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  567

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  568
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  568

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  569
<211>  101
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  569

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  570
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  570

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  571
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  571

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  572
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  572

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  573
<211>  171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  573

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  574
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  574

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  575
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  575

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  576
<211>  207
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  576

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  577
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  577

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  578
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  578

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  579
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  579

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  580
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  580

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  581
<211>  164
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  581

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  582
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  582

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  583
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  583

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  584
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  584

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  585
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  585

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  586
<211>  226
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  586

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  587
<211>  188
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  587

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  588
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  588

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  589
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  589

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  590
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  590

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  591
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  591

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  592
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  592

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  593
<211>  619
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  593

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  594
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  594

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  595
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  595

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  596
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  596

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  597
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  597

His His His His His 
1               5   


<210>  598
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  598

His His His His His His 
1               5       


<210>  599
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  599

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  600
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  600

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  601
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  601

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  602
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  602

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  603
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  603

Arg Tyr Ile Arg Ser 
1               5   


<210>  604
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  604

Phe His His Thr 
1               


<210>  605
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  605

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  606
<211>  75
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  606

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ser Arg Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser Thr Ser Pro Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu 
    50                  55                  60                  


Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly Ser 
65                  70                  75  


<210>  607
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  607

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
            20                  25                  30          


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        35                  40                  45              


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    50                  55                  60                  


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Thr Ser Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu 
                85                  90                  95      


Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg 
            100                 105                 110         


Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr 
        115                 120                 125             


Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His 
    130                 135                 140                 


Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe 
145                 150                 155                 160 


Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu 
                165                 170                 175     


Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln 
            180                 185                 190         


Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu 
        195                 200                 205             


Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly 
    210                 215                 220                 


Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp 
225                 230                 235                 240 


Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu 
                245                 250                 255     


Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser 
            260                 265                 270         


Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln 
        275                 280                 285             


Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro 
    290                 295                 300                 


Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu 
305                 310                 315                 320 


Arg Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys 
                325                 330                 335     


Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys 
            340                 345                 350         


Asp Leu Tyr Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  608
<211>  388
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  608

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Pro Lys Lys 
        355                 360                 365             


Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser 
    370                 375                 380                 


Asp Ala Gly Ser 
385             


<210>  609
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  609

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
            20                  25                  30          


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        35                  40                  45              


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    50                  55                  60                  


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Thr Ser Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu 
                85                  90                  95      


Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg 
            100                 105                 110         


Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr 
        115                 120                 125             


Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His 
    130                 135                 140                 


Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe 
145                 150                 155                 160 


Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu 
                165                 170                 175     


Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln 
            180                 185                 190         


Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu 
        195                 200                 205             


Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly 
    210                 215                 220                 


Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp 
225                 230                 235                 240 


Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu 
                245                 250                 255     


Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser 
            260                 265                 270         


Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln 
        275                 280                 285             


Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro 
    290                 295                 300                 


Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu 
305                 310                 315                 320 


Arg Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys 
                325                 330                 335     


Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys 
            340                 345                 350         


Asp Leu Tyr Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  610
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  610

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Met His Gly 
        355                 360                 365             


Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn 
    370                 375                 380                 


Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly 
385                 390                 395                 400 


Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys 
                405                 410                 415     


Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg 
            420                 425                 430         


Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly Ser 
        435                 440                 445 


<210>  611
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  611

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
            20                  25                  30          


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        35                  40                  45              


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    50                  55                  60                  


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Thr Ser Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu 
                85                  90                  95      


Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg 
            100                 105                 110         


Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr 
        115                 120                 125             


Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His 
    130                 135                 140                 


Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe 
145                 150                 155                 160 


Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu 
                165                 170                 175     


Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln 
            180                 185                 190         


Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu 
        195                 200                 205             


Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly 
    210                 215                 220                 


Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp 
225                 230                 235                 240 


Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu 
                245                 250                 255     


Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser 
            260                 265                 270         


Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln 
        275                 280                 285             


Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro 
    290                 295                 300                 


Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu 
305                 310                 315                 320 


Arg Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys 
                325                 330                 335     


Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys 
            340                 345                 350         


Asp Leu Tyr Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  612
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  612

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Pro Lys Lys 
        355                 360                 365             


Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser 
    370                 375                 380                 


Asp Ala Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Lys Glu Asn Asn 
385                 390                 395                 400 


Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Ser Lys Lys Glu Asn Asn Ala Leu Leu Arg 
            420                 425                 430         


Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly Ser 
        435                 440                 445 


<210>  613
<211>  477
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  613

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
            20                  25                  30          


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        35                  40                  45              


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    50                  55                  60                  


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Thr Ser Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu 
                85                  90                  95      


Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg 
            100                 105                 110         


Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr 
        115                 120                 125             


Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His 
    130                 135                 140                 


Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe 
145                 150                 155                 160 


Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu 
                165                 170                 175     


Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln 
            180                 185                 190         


Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu 
        195                 200                 205             


Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly 
    210                 215                 220                 


Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp 
225                 230                 235                 240 


Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu 
                245                 250                 255     


Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser 
            260                 265                 270         


Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln 
        275                 280                 285             


Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro 
    290                 295                 300                 


Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu 
305                 310                 315                 320 


Arg Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys 
                325                 330                 335     


Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys 
            340                 345                 350         


Asp Leu Tyr Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
        355                 360                 365             


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
    370                 375                 380                 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
385                 390                 395                 400 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                405                 410                 415     


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
            420                 425                 430         


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
        435                 440                 445             


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
    450                 455                 460                 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475         


<210>  614
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  614

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Ser Arg Gly Ser Gly Ser 
        35                  40                  45              


Gly Ser Thr Ser Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly 
    50                  55                  60                  


Leu Gln Asp Asp Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala Phe Gln 
65                  70                  75                  80  


Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Ser Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly 
            100                 105                 110         


Leu Gln Asp Asp Gly 
        115         


<210>  615
<211>  381
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  615

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
            20                  25                  30          


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        35                  40                  45              


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    50                  55                  60                  


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
                85                  90                  95      


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
            100                 105                 110         


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
        115                 120                 125             


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
    130                 135                 140                 


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
145                 150                 155                 160 


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
                165                 170                 175     


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
            180                 185                 190         


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
        195                 200                 205             


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
    210                 215                 220                 


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
225                 230                 235                 240 


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
                245                 250                 255     


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
            260                 265                 270         


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
        275                 280                 285             


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
    290                 295                 300                 


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
305                 310                 315                 320 


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
                325                 330                 335     


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
            340                 345                 350         


Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu 
        355                 360                 365             


Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr Ser 
    370                 375                 380     


<210>  616
<211>  431
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  616

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
                245                 250                 255     


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
            260                 265                 270         


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
        275                 280                 285             


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
    290                 295                 300                 


Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Asp Ala Phe 
        355                 360                 365             


Gln Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg 
385                 390                 395                 400 


Gly Leu Gln Asp Asp Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala Phe 
                405                 410                 415     


Gln Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Ser 
            420                 425                 430     


<210>  617
<211>  429
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  617

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
    130                 135                 140                 


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
145                 150                 155                 160 


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
                165                 170                 175     


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
            180                 185                 190         


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
        195                 200                 205             


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
    210                 215                 220                 


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
225                 230                 235                 240 


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
                245                 250                 255     


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
            260                 265                 270         


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
        275                 280                 285             


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
    290                 295                 300                 


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
305                 310                 315                 320 


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
                325                 330                 335     


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
            340                 345                 350         


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
        355                 360                 365             


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
    370                 375                 380                 


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
385                 390                 395                 400 


Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu 
                405                 410                 415     


Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr Ser 
            420                 425                 


<210>  618
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  618

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  619
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  619

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  620
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  620

Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr 
1               5                   10                  15      


Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp 
            20                  25                  30          


Val Thr Leu 
        35  


<210>  621
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  621

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  622
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  622

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  623
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  623

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  624
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  624

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  625
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  625

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  626
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  626

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  627
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  627

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  628
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  628

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  629
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  629

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  630
<211>  101
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  630

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  631
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  631

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  632
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  632

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  633
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  633

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  634
<211>  171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  634

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  635
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  635

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  636
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  636

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  637
<211>  207
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  637

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  638
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  638

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  639
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  639

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  640
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  640

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  641
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  641

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  642
<211>  164
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  642

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  643
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  643

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  644
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  644

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  645
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  645

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  646
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  646

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  647
<211>  226
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  647

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  648
<211>  188
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  648

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  649
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  649

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  650
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  650

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  651
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  651

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  652
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  652

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  653
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  653

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  654
<211>  619
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  654

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  655
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  655

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  656
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  656

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  657
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  657

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  658
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  658

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  659
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  659

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  660
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  660

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  661
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  661

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  662
<211>  203
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  662

Cys Ser Ser Asp Asp Arg Gly His Ser Ser Leu Thr Asn Ser Pro Leu 
1               5                   10                  15      


Asp Ser Ser Cys Lys Glu Ser Ser Val Ser Val Thr Ser Pro Ser Gly 
            20                  25                  30          


Val Ser Ser Ser Thr Ser Gly Gly Val Ser Ser Thr Ser Asn Met His 
        35                  40                  45              


Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln 
    50                  55                  60                  


Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val 
                85                  90                  95      


Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu 
            100                 105                 110         


Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Leu Ser Lys Glu 
        115                 120                 125             


Leu Gln Pro Gln Val Glu Gly Val Asp Asn Lys Met Ser Gln Cys Thr 
    130                 135                 140                 


Ser Ser Thr Ile Pro Ser Ser Ser Gln Glu Lys Asp Pro Lys Ile Lys 
145                 150                 155                 160 


Thr Glu Thr Ser Glu Glu Gly Ser Gly Asp Leu Asp Asn Leu Asp Ala 
                165                 170                 175     


Ile Leu Gly Asp Leu Thr Ser Ser Asp Phe Tyr Asn Asn Ser Ile Ser 
            180                 185                 190         


Ser Asn Gly Ser His Leu Gly Thr Lys Gln Gln 
        195                 200             


<210>  663
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  663

Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val Ser 
1               5                   10                  15      


Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys Asp 
            20                  25                  30          


Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu Arg 
        35                  40                  45              


Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala Met 
    50                  55                  60                  


Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn Ser 
                85                  90                  95      


Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala Gly 
            100                 105                 110         


Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr Ala 
        115                 120                 125             


Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu Arg 
    130                 135                 140                 


Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly Arg 
145                 150                 155                 160 


Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser Pro 
                165                 170                 175     


Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr Ser 
            180                 185                 190         


Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly Asn 
        195                 200                 205             


Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser Ala 
    210                 215                 220                 


Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser Ala 
225                 230                 235                 240 


Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro Val 
                245                 250                 255     


Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg Pro 
            260                 265                 270         


Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met Asn 
        275                 280                 285             


Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    290                 295                 300     


<210>  664
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  664

Asn Tyr Gly Thr Asn Pro Gly Thr Pro Pro Ala Ser Thr Ser Pro Phe 
1               5                   10                  15      


Ser Gln Leu Ala Ala Asn Pro Glu Ala Ser Leu Ala Asn Arg Asn Ser 
            20                  25                  30          


Met Val Ser Arg Gly Met Thr Gly Asn Ile Gly Gly Gln Phe Gly Thr 
        35                  40                  45              


Gly Ile Asn Pro Gln Met Gln Gln Asn Val Phe Gln Tyr Pro Gly Ala 
    50                  55                  60                  


Gly Met Val Pro Gln Gly Glu Ala Asn Phe Ala Pro Ser Leu Ser Pro 
65                  70                  75                  80  


Gly Ser Ser Met Val Pro Met Pro Ile Pro Pro Pro Gln Ser Ser Leu 
                85                  90                  95      


Leu Gln Gln Thr Pro Pro Ala Ser Gly Tyr Gln Ser Pro Asp Met Lys 
            100                 105                 110         


Ala Trp Gln Gln Gly Ala Ile Gly Asn Asn Asn Val Phe Ser Gln Ala 
        115                 120                 125             


Val Gln Asn Gln Pro Thr Pro Ala Gln Pro Gly Val Tyr Asn Asn Met 
    130                 135                 140                 


Ser Ile Thr Val Ser Met Ala Gly Gly Asn Thr Asn Val Gln Asn Met 
145                 150                 155                 160 


Asn Pro Met Met Ala Gln Met Gln Met Ser Ser Leu Gln Met Pro Gly 
                165                 170                 175     


Met Asn Thr Val Cys Pro Glu Gln Ile Asn Asp Pro Ala Leu Arg His 
            180                 185                 190         


Thr Gly Leu Tyr Cys Asn Gln Leu Ser Ser Thr Asp Leu Leu Lys Thr 
        195                 200                 205             


Glu Ala Asp Gly Thr Gln Gln Val Gln Gln Val Gln Val Phe Ala Asp 
    210                 215                 220                 


Val Gln Cys Thr Val Asn Leu Val Gly Gly Asp Pro Tyr Leu Asn Gln 
225                 230                 235                 240 


Pro Gly Pro Leu Gly Thr Gln Lys Pro Thr Ser Gly Pro Gln Thr Pro 
                245                 250                 255     


Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
            260                 265                 270 


<210>  665
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  665

Lys Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln 
1               5                   10                  15      


Ile Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr 
            20                  25                  30          


Lys Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val 
        35                  40                  45              


Ile Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn 
    50                  55                  60                  


Pro Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser 
65                  70                  75                  80  


Ser Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln 
                85                  90                  95      


Asp Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys 
            100                 105                 110         


Glu Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met 
        115                 120                 125             


Asn His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr 
    130                 135                 140                 


Ala Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro 
145                 150                 155                 160 


Gly Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly 
                165                 170                 175     


Val Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly 
            180                 185                 190         


Ser Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His 
        195                 200                 205             


Ser Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly 
    210                 215                 220                 


His Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met 
225                 230                 235                 240 


Gly Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser 
                245                 250                 255     


Lys Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu 
            260                 265                 270         


Pro Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly 
        275                 280                 285             


Glu Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser 
    290                 295                 300                 


Glu Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr 
305                 310                 315                 320 


Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser 
                325                 330                 335     


Pro Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser 
            340                 345                 350         


Leu Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His 
        355                 360                 365             


Lys Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu 
    370                 375                 380                 


Ala Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser 
385                 390                 395                 400 


Ser Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val 
                405                 410                 415     


Ser Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys 
            420                 425                 430         


Asp Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu 
        435                 440                 445             


Arg Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala 
    450                 455                 460                 


Met Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro 
465                 470                 475                 480 


Gly Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn 
                485                 490                 495     


Ser Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala 
            500                 505                 510         


Gly Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr 
        515                 520                 525             


Ala Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu 
    530                 535                 540                 


Arg Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly 
545                 550                 555                 560 


Arg Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser 
                565                 570                 575     


Pro Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr 
            580                 585                 590         


Ser Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly 
        595                 600                 605             


Asn Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser 
    610                 615                 620                 


Ala Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser 
625                 630                 635                 640 


Ala Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro 
                645                 650                 655     


Val Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg 
            660                 665                 670         


Pro Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met 
        675                 680                 685             


Asn Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    690                 695                 700         


<210>  666
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  666

Asn Tyr Gly Thr Asn Pro Gly Thr Pro Pro Ala Ser Thr Ser Pro Phe 
1               5                   10                  15      


Ser Gln Leu Ala Ala Asn Pro Glu Ala Ser Leu Ala Asn Arg Asn Ser 
            20                  25                  30          


Met Val Ser Arg Gly Met Thr Gly Asn Ile Gly Gly Gln Phe Gly Thr 
        35                  40                  45              


Gly Ile Asn Pro Gln Met Gln Gln Asn Val Phe Gln Tyr Pro Gly Ala 
    50                  55                  60                  


Gly Met Val Pro Gln Gly Glu Ala Asn Phe Ala Pro Ser Leu Ser Pro 
65                  70                  75                  80  


Gly Ser Ser Met Val Pro Met Pro Ile Pro Pro Pro Gln Ser Ser Leu 
                85                  90                  95      


Leu Gln Gln Thr Pro Pro Ala Ser Gly Tyr Gln Ser Pro Asp Met Lys 
            100                 105                 110         


Ala Trp Gln Gln Gly Ala Ile Gly Asn Asn Asn Val Phe Ser Gln Ala 
        115                 120                 125             


Val Gln Asn Gln Pro Thr Pro Ala Gln Pro Gly Val Tyr Asn Asn Met 
    130                 135                 140                 


Ser Ile Thr Val Ser Met Ala Gly Gly Asn Thr Asn Val Gln Asn Met 
145                 150                 155                 160 


Asn Pro Met Met Ala Gln Met Gln Met Ser Ser Leu Gln Met Pro Gly 
                165                 170                 175     


Met Asn Thr Val Cys Pro Glu Gln Ile Asn Asp Pro Ala Leu Arg His 
            180                 185                 190         


Thr Gly Leu Tyr Cys Asn Gln Leu Ser Ser Thr Asp Leu Leu Lys Thr 
        195                 200                 205             


Glu Ala Asp Gly Thr Gln Gln Val Gln Gln Val Gln Val Phe Ala Asp 
    210                 215                 220                 


Val Gln Cys Thr Val Asn Leu Val Gly Gly Asp Pro Tyr Leu Asn Gln 
225                 230                 235                 240 


Pro Gly Pro Leu Gly Thr Gln Lys Pro Thr Ser Gly Pro Gln Thr Pro 
                245                 250                 255     


Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
            260                 265                 270 


<210>  667
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  667

Lys Arg His His His Glu Val Leu Arg Gln Gly Leu Ala Phe Ser Gln 
1               5                   10                  15      


Ile Tyr Arg Phe Ser Leu Ser Asp Gly Thr Leu Val Ala Ala Gln Thr 
            20                  25                  30          


Lys Ser Lys Leu Ile Arg Ser Gln Thr Thr Asn Glu Pro Gln Leu Val 
        35                  40                  45              


Ile Ser Leu His Met Leu His Arg Glu Gln Asn Val Cys Val Met Asn 
    50                  55                  60                  


Pro Asp Leu Thr Gly Gln Thr Met Gly Lys Pro Leu Asn Pro Ile Ser 
65                  70                  75                  80  


Ser Asn Ser Pro Ala His Gln Ala Leu Cys Ser Gly Asn Pro Gly Gln 
                85                  90                  95      


Asp Met Thr Leu Ser Ser Asn Ile Asn Phe Pro Ile Asn Gly Pro Lys 
            100                 105                 110         


Glu Gln Met Gly Met Pro Met Gly Arg Phe Gly Gly Ser Gly Gly Met 
        115                 120                 125             


Asn His Val Ser Gly Met Gln Ala Thr Thr Pro Gln Gly Ser Asn Tyr 
    130                 135                 140                 


Ala Leu Lys Met Asn Ser Pro Ser Gln Ser Ser Pro Gly Met Asn Pro 
145                 150                 155                 160 


Gly Gln Pro Thr Ser Met Leu Ser Pro Arg His Arg Met Ser Pro Gly 
                165                 170                 175     


Val Ala Gly Ser Pro Arg Ile Pro Pro Ser Gln Phe Ser Pro Ala Gly 
            180                 185                 190         


Ser Leu His Ser Pro Val Gly Val Cys Ser Ser Thr Gly Asn Ser His 
        195                 200                 205             


Ser Tyr Thr Asn Ser Ser Leu Asn Ala Leu Gln Ala Leu Ser Glu Gly 
    210                 215                 220                 


His Gly Val Ser Leu Gly Ser Ser Leu Ala Ser Pro Asp Leu Lys Met 
225                 230                 235                 240 


Gly Asn Leu Gln Asn Ser Pro Val Asn Met Asn Pro Pro Pro Leu Ser 
                245                 250                 255     


Lys Met Gly Ser Leu Asp Ser Lys Asp Cys Phe Gly Leu Tyr Gly Glu 
            260                 265                 270         


Pro Ser Glu Gly Thr Thr Gly Gln Ala Glu Ser Ser Cys His Pro Gly 
        275                 280                 285             


Glu Gln Lys Glu Thr Asn Asp Pro Asn Leu Pro Pro Ala Val Ser Ser 
    290                 295                 300                 


Glu Arg Ala Asp Gly Gln Ser Arg Leu His Asp Ser Lys Gly Gln Thr 
305                 310                 315                 320 


Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Met Glu Pro Ser 
                325                 330                 335     


Pro Leu Ala Ser Ser Leu Ser Asp Thr Asn Lys Asp Ser Thr Gly Ser 
            340                 345                 350         


Leu Pro Gly Ser Gly Ser Thr His Gly Thr Ser Leu Lys Glu Lys His 
        355                 360                 365             


Lys Ile Leu His Arg Leu Leu Gln Asp Ser Ser Ser Pro Val Asp Leu 
    370                 375                 380                 


Ala Lys Leu Thr Ala Glu Ala Thr Gly Lys Asp Leu Ser Gln Glu Ser 
385                 390                 395                 400 


Ser Ser Thr Ala Pro Gly Ser Glu Val Thr Ile Lys Gln Glu Pro Val 
                405                 410                 415     


Ser Pro Lys Lys Lys Glu Asn Ala Leu Leu Arg Tyr Leu Leu Asp Lys 
            420                 425                 430         


Asp Asp Thr Lys Asp Ile Gly Leu Pro Glu Ile Thr Pro Lys Leu Glu 
        435                 440                 445             


Arg Leu Asp Ser Lys Thr Asp Pro Ala Ser Asn Thr Lys Leu Ile Ala 
    450                 455                 460                 


Met Lys Thr Glu Lys Glu Glu Met Ser Phe Glu Pro Gly Asp Gln Pro 
465                 470                 475                 480 


Gly Ser Glu Leu Asp Asn Leu Glu Glu Ile Leu Asp Asp Leu Gln Asn 
                485                 490                 495     


Ser Gln Leu Pro Gln Leu Phe Pro Asp Thr Arg Pro Gly Ala Pro Ala 
            500                 505                 510         


Gly Ser Val Asp Lys Gln Ala Ile Ile Asn Asp Leu Met Gln Leu Thr 
        515                 520                 525             


Ala Glu Asn Ser Pro Val Thr Pro Val Gly Ala Gln Lys Thr Ala Leu 
    530                 535                 540                 


Arg Ile Ser Gln Ser Thr Phe Asn Asn Pro Arg Pro Gly Gln Leu Gly 
545                 550                 555                 560 


Arg Leu Leu Pro Asn Gln Asn Leu Pro Leu Asp Ile Thr Leu Gln Ser 
                565                 570                 575     


Pro Thr Gly Ala Gly Pro Phe Pro Pro Ile Arg Asn Ser Ser Pro Tyr 
            580                 585                 590         


Ser Val Ile Pro Gln Pro Gly Met Met Gly Asn Gln Gly Met Ile Gly 
        595                 600                 605             


Asn Gln Gly Asn Leu Gly Asn Ser Ser Thr Gly Met Ile Gly Asn Ser 
    610                 615                 620                 


Ala Ser Arg Pro Thr Met Pro Ser Gly Glu Trp Ala Pro Gln Ser Ser 
625                 630                 635                 640 


Ala Val Arg Val Thr Cys Ala Ala Thr Thr Ser Ala Met Asn Arg Pro 
                645                 650                 655     


Val Gln Gly Gly Met Ile Arg Asn Pro Ala Ala Ser Ile Pro Met Arg 
            660                 665                 670         


Pro Ser Ser Gln Pro Gly Gln Arg Gln Thr Leu Gln Ser Gln Val Met 
        675                 680                 685             


Asn Ile Gly Pro Ser Glu Leu Glu Met Asn Met Gly Gly Pro 
    690                 695                 700         


<210>  668
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  668

Leu Leu Arg Tyr Leu Leu Asp Lys 
1               5               


<210>  669
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  669

Cys Asp Pro Ala Ser Asn Leu Gly Leu Glu Asp Ile Ile Arg Lys Ala 
1               5                   10                  15      


Leu Met Gly Ser Phe Asp Asp Lys 
            20                  


<210>  670
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  670

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  671
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  671

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  672
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  672

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  673
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  673

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  674
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  674

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  675
<211>  275
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  675

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Thr Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  676
<211>  275
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  676

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  677
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  677

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  678
<211>  309
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  678

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Ala Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Phe 
305                 


<210>  679
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  679

Met Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val Pro Glu Gly 
1               5                   10                  15      


Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala Ile Tyr Asn 
            20                  25                  30          


Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr Ser Leu Leu 
        35                  40                  45              


Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg Leu Asn Ala 
    50                  55                  60                  


Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile Ala Ala Ser 
65                  70                  75                  80  


Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg Pro Thr Ser 
                85                  90                  95      


Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser Leu Ile Val 
            100                 105                 110         


His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
        115                 120                 125             


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
145                 150                 155                 160 


Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
                165                 170                 175     


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
            180                 185                 190         


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205             


<210>  680
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  680

Met Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly Gln 
1               5                   10                  15      


Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His Glu Tyr Met Ser 
            20                  25                  30          


Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser 
        35                  40                  45              


Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro Asn Gly Tyr Asn 
    50                  55                  60                  


Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg Leu Leu Ser Ala 
65                  70                  75                  80  


Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Val Gly 
                85                  90                  95      


Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val Leu 
            100                 105                 110         


Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro 
        115                 120                 125             


Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
145                 150                 155                 160 


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
                165                 170                 175     


Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Ala Leu Ser Ser Arg Leu 
            180                 185                 190         


Arg Val Ser Ala Thr Phe Trp Gln Asp Pro Arg Asn His Phe Arg Cys 
        195                 200                 205             


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp 
    210                 215                 220                 


Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg 
225                 230                 235                 240 


Ala Asp 
        


<210>  681
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  681

Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly 
1               5                   10                  15      


Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp 
            20                  25                  30          


Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro 
        35                  40                  45              


Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro 
    50                  55                  60                  


Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly 
65                  70                  75                  80  


Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp 
                85                  90                  95      


Pro Leu 
        


<210>  682
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  682

Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro Leu Thr Thr Gly Val 
1               5                   10                  15      


Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys Glu Lys Gln Phe Gln 
            20                  25                  30          


Pro Tyr Phe Ile Pro Ile Asn 
        35                  


<210>  683
<211>  258
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  683

Tyr Asp Leu Leu Gln Arg Leu Gly Gly Gly Thr Tyr Gly Glu Val Phe 
1               5                   10                  15      


Lys Ala Arg Asp Lys Val Ser Gly Asp Leu Val Ala Leu Lys Met Val 
            20                  25                  30          


Lys Met Glu Pro Asp Asp Asp Val Ser Thr Leu Gln Lys Glu Ile Leu 
        35                  40                  45              


Ile Leu Lys Thr Cys Arg His Ala Asn Ile Val Ala Tyr His Gly Ser 
    50                  55                  60                  


Tyr Leu Trp Leu Gln Lys Leu Trp Ile Cys Met Glu Phe Cys Gly Ala 
65                  70                  75                  80  


Gly Ser Leu Gln Asp Ile Tyr Gln Val Thr Gly Ser Leu Ser Glu Leu 
                85                  90                  95      


Gln Ile Ser Tyr Val Cys Arg Glu Val Leu Gln Gly Leu Ala Tyr Leu 
            100                 105                 110         


His Ser Gln Lys Lys Ile His Arg Asp Ile Lys Gly Ala Asn Ile Leu 
        115                 120                 125             


Ile Asn Asp Ala Gly Glu Val Arg Leu Ala Asp Phe Gly Ile Ser Ala 
    130                 135                 140                 


Gln Ile Gly Ala Thr Leu Ala Arg Arg Leu Ser Phe Ile Gly Thr Pro 
145                 150                 155                 160 


Tyr Trp Met Ala Pro Glu Val Ala Ala Val Ala Leu Lys Gly Gly Tyr 
                165                 170                 175     


Asn Glu Leu Cys Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu 
            180                 185                 190         


Ala Glu Leu Gln Pro Pro Leu Phe Asp Val His Pro Leu Arg Val Leu 
        195                 200                 205             


Phe Leu Met Thr Lys Ser Gly Tyr Gln Pro Pro Arg Leu Lys Glu Lys 
    210                 215                 220                 


Gly Lys Trp Ser Ala Ala Phe His Asn Phe Ile Lys Val Thr Leu Thr 
225                 230                 235                 240 


Lys Ser Pro Lys Lys Arg Pro Ser Ala Thr Lys Met Leu Ser His Gln 
                245                 250                 255     


Leu Val 
        


<210>  684
<211>  272
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  684

Phe Trp Glu Glu Phe Glu Ser Leu Gln Lys Gln Glu Val Lys Asn Leu 
1               5                   10                  15      


His Gln Arg Leu Glu Gly Gln Arg Pro Glu Asn Lys Gly Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Ser Arg Val Ile Leu Gln Gly 
        35                  40                  45              


Arg Asp Ser Asn Ile Pro Gly Ser Asp Tyr Ile Asn Ala Asn Tyr Ile 
    50                  55                  60                  


Lys Asn Gln Leu Leu Gly Pro Asp Glu Asn Ala Lys Thr Tyr Ile Ala 
65                  70                  75                  80  


Ser Gln Gly Cys Leu Glu Ala Thr Val Asn Asp Phe Trp Gln Met Ala 
                85                  90                  95      


Trp Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Arg Glu Val Glu 
            100                 105                 110         


Lys Gly Arg Asn Lys Cys Val Pro Tyr Trp Pro Glu Val Gly Met Gln 
        115                 120                 125             


Arg Ala Tyr Gly Pro Tyr Ser Val Thr Asn Cys Gly Glu His Asp Thr 
    130                 135                 140                 


Thr Glu Tyr Lys Leu Arg Thr Leu Gln Val Ser Pro Leu Asp Asn Gly 
145                 150                 155                 160 


Asp Leu Ile Arg Glu Ile Trp His Tyr Gln Tyr Leu Ser Trp Pro Asp 
                165                 170                 175     


His Gly Val Pro Ser Glu Pro Gly Gly Val Leu Ser Phe Leu Asp Gln 
            180                 185                 190         


Ile Asn Gln Arg Gln Glu Ser Leu Pro His Ala Gly Pro Ile Ile Val 
        195                 200                 205             


His Cys Ser Ala Gly Ile Gly Arg Thr Gly Thr Ile Ile Val Ile Asp 
    210                 215                 220                 


Met Leu Met Glu Asn Ile Ser Thr Lys Gly Leu Asp Cys Asp Ile Asp 
225                 230                 235                 240 


Ile Gln Lys Thr Ile Gln Met Val Arg Ala Gln Arg Ser Gly Met Val 
                245                 250                 255     


Gln Thr Glu Ala Gln Tyr Lys Phe Ile Tyr Val Ala Ile Ala Gln Phe 
            260                 265                 270         


<210>  685
<211>  275
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  685

Phe Trp Glu Glu Phe Glu Thr Leu Gln Gln Gln Glu Cys Lys Leu Leu 
1               5                   10                  15      


Tyr Ser Arg Lys Glu Gly Gln Arg Gln Glu Asn Lys Asn Lys Asn Arg 
            20                  25                  30          


Tyr Lys Asn Ile Leu Pro Phe Asp His Thr Arg Val Val Leu His Asp 
        35                  40                  45              


Gly Asp Pro Asn Glu Pro Val Ser Asp Tyr Ile Asn Ala Asn Ile Ile 
    50                  55                  60                  


Met Pro Glu Phe Glu Thr Lys Cys Asn Asn Ser Lys Pro Lys Lys Ser 
65                  70                  75                  80  


Tyr Ile Ala Thr Gln Gly Cys Leu Gln Asn Thr Val Asn Asp Phe Trp 
                85                  90                  95      


Arg Met Val Phe Gln Glu Asn Ser Arg Val Ile Val Met Thr Thr Lys 
            100                 105                 110         


Glu Val Glu Arg Gly Lys Ser Lys Cys Val Lys Tyr Trp Pro Asp Glu 
        115                 120                 125             


Tyr Ala Leu Lys Glu Tyr Gly Val Met Arg Val Arg Asn Val Lys Glu 
    130                 135                 140                 


Ser Ala Ala His Asp Tyr Thr Leu Arg Glu Leu Lys Leu Ser Lys Val 
145                 150                 155                 160 


Gly Gln Ala Leu Leu Gln Gly Asn Thr Glu Arg Thr Val Trp Gln Tyr 
                165                 170                 175     


His Phe Arg Thr Trp Pro Asp His Gly Val Pro Ser Asp Pro Gly Gly 
            180                 185                 190         


Val Leu Asp Phe Leu Glu Glu Val His His Lys Gln Glu Ser Ile Met 
        195                 200                 205             


Asp Ala Gly Pro Val Val Val His Cys Ser Ala Gly Ile Gly Arg Thr 
    210                 215                 220                 


Gly Thr Phe Ile Val Ile Asp Ile Leu Ile Asp Ile Ile Arg Glu Lys 
225                 230                 235                 240 


Gly Val Asp Cys Asp Ile Asp Val Pro Lys Thr Ile Gln Met Val Arg 
                245                 250                 255     


Ser Gln Arg Ser Gly Met Val Gln Thr Glu Ala Gln Tyr Arg Phe Ile 
            260                 265                 270         


Tyr Met Ala 
        275 


<210>  686
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  686

Gly Pro Gln Lys Arg Cys Leu Phe Val Cys Arg His Gly Glu Arg Met 
1               5                   10                  15      


Asp Val Val Phe Gly Lys Tyr Trp Leu Ser Gln Cys Phe Asp Ala Lys 
            20                  25                  30          


Gly Arg Tyr Ile Arg Thr Asn Leu Asn Met Pro His Ser Leu Pro Gln 
        35                  40                  45              


Arg Ser Gly Gly Phe Arg Asp Tyr Glu Lys Asp Ala Pro Ile Thr Val 
    50                  55                  60                  


Phe Gly Cys Met Gln Ala Arg Leu Val Gly Glu Ala Leu Leu Glu Ser 
65                  70                  75                  80  


Asn Thr Ile Ile Asp His Val Tyr Cys Ser Pro Ser Leu Arg Cys Val 
                85                  90                  95      


Gln Thr Ala His Asn Ile Leu Lys Gly Leu Gln Gln Glu Asn His Leu 
            100                 105                 110         


Lys Ile Arg Val Glu Pro Gly Leu Phe Glu Trp Thr Lys Trp Val Ala 
        115                 120                 125             


Gly Ser Thr Leu Pro Ala Trp Ile Pro Pro Ser Glu Leu Ala Ala Ala 
    130                 135                 140                 


Asn Leu Ser Val Asp Thr Thr Tyr Arg Pro His Ile Pro Ile Ser Lys 
145                 150                 155                 160 


Leu Val Val Ser Glu Ser Tyr Asp Thr Tyr Ile Ser Arg Ser Phe Gln 
                165                 170                 175     


Val Thr Lys Glu Ile Ile Ser Glu Cys Lys Ser Lys Gly Asn Asn Ile 
            180                 185                 190         


Leu Ile Val Ala His Ala Ser Ser Leu Glu Ala Cys Thr Cys Gln Leu 
        195                 200                 205             


Gln Gly Leu Ser Pro Gln Asn Ser Lys Asp Phe Val Gln Met Val Arg 
    210                 215                 220                 


Lys Ile Pro Tyr Leu Gly Phe Cys Ser Cys Glu Glu Leu Gly Glu Thr 
225                 230                 235                 240 


Gly Ile Trp Gln Leu Thr Asp Pro Pro Ile Leu Pro Leu Thr His Gly 
                245                 250                 255     


Pro Thr Gly Gly Phe Asn Trp Arg Glu Thr Leu Leu Gln Glu 
            260                 265                 270 


<210>  687
<211>  255
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  687

Leu Lys Leu Leu Gln Thr Ile Gly Lys Gly Glu Phe Gly Asp Val Met 
1               5                   10                  15      


Leu Gly Asp Tyr Arg Gly Asn Lys Val Ala Val Lys Cys Ile Lys Asn 
            20                  25                  30          


Asp Ala Thr Ala Gln Ala Phe Leu Ala Glu Ala Ser Val Met Thr Gln 
        35                  40                  45              


Leu Arg His Ser Asn Leu Val Gln Leu Leu Gly Val Ile Val Glu Glu 
    50                  55                  60                  


Lys Gly Gly Leu Tyr Ile Val Thr Glu Tyr Met Ala Lys Gly Ser Leu 
65                  70                  75                  80  


Val Asp Tyr Leu Arg Ser Arg Gly Arg Ser Val Leu Gly Gly Asp Cys 
                85                  90                  95      


Leu Leu Lys Phe Ser Leu Asp Val Cys Glu Ala Met Glu Tyr Leu Glu 
            100                 105                 110         


Gly Asn Asn Phe Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val 
        115                 120                 125             


Ser Glu Asp Asn Val Ala Lys Val Ser Asp Phe Gly Leu Thr Lys Glu 
    130                 135                 140                 


Ala Ser Ser Thr Gln Asp Thr Gly Lys Leu Pro Val Lys Trp Thr Ala 
145                 150                 155                 160 


Pro Glu Ala Leu Arg Glu Lys Lys Phe Ser Thr Lys Ser Asp Val Trp 
                165                 170                 175     


Ser Phe Gly Ile Leu Leu Trp Glu Ile Tyr Ser Phe Gly Arg Val Pro 
            180                 185                 190         


Tyr Pro Arg Ile Pro Leu Lys Asp Val Val Pro Arg Val Glu Lys Gly 
        195                 200                 205             


Tyr Lys Met Asp Ala Pro Asp Gly Cys Pro Pro Ala Val Tyr Glu Val 
    210                 215                 220                 


Met Lys Asn Cys Trp His Leu Asp Ala Ala Met Arg Pro Ser Phe Leu 
225                 230                 235                 240 


Gln Leu Arg Glu Gln Leu Glu His Ile Lys Thr His Glu Leu His 
                245                 250                 255 


<210>  688
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  688

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  689
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  689

Leu Gly Leu Leu Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly 
1               5                   10                  15      


Val Ala Ile His Leu Cys Cys 
            20              


<210>  690
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  690

Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
1               5                   10                  15      


Leu Gly Ile Phe Phe Cys Val Arg Cys 
            20                  25  


<210>  691
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  691

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu Arg Val 
            20              


<210>  692
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  692

Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
1               5                   10                  15      


Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25      


<210>  693
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  693

Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly Pro 
1               5                   10                  15      


Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
            20                  25      


<210>  694
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  694

Ala Leu Pro Ala Ala Leu Ala Val Ile Ser Phe Leu Leu Gly Leu Gly 
1               5                   10                  15      


Leu Gly Val Ala Cys Val Leu Ala 
            20                  


<210>  695
<211>  271
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  695

Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr 
1               5                   10                  15      


Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr 
            20                  25                  30          


Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp Met Asn Ser 
        35                  40                  45              


Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile Thr Pro Leu 
    50                  55                  60                  


Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln Gly Cys Gln 
65                  70                  75                  80  


Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser 
                85                  90                  95      


Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu 
            100                 105                 110         


Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala Ser Leu Met 
        115                 120                 125             


Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe Met Thr Arg 
    130                 135                 140                 


Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe Met Glu Pro 
145                 150                 155                 160 


Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser 
                165                 170                 175     


Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly Asp Arg Pro 
            180                 185                 190         


Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu 
        195                 200                 205             


Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu Ser Ser Gln 
    210                 215                 220                 


Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg Gln Ile Val 
225                 230                 235                 240 


Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys Thr Glu Thr Asp 
                245                 250                 255     


Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            260                 265                 270     


<210>  696
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  696

Pro Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp 
1               5                   10                  15      


Asp Pro Ser Asp Ala 
            20      


<210>  697
<211>  79
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  697

Pro Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp 
1               5                   10                  15      


Asp Pro Ser Asp Ala Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Lys 
            20                  25                  30          


Glu Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser 
        35                  40                  45              


Asp Ala Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Lys Glu Asn Asn 
    50                  55                  60                  


Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala 
65                  70                  75                  


<210>  698
<211>  78
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  698

Met His Gly Ser Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu 
1               5                   10                  15      


Leu Gln Asn Gly Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu 
            20                  25                  30          


Ala Thr Gly Lys Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn 
        35                  40                  45              


Val Val Lys Gln Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala 
    50                  55                  60                  


Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala 
65                  70                  75              


<210>  699
<211>  419
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  699

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Pro Lys Lys Glu 
385                 390                 395                 400 


Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp 
                405                 410                 415     


Ala Gly Ser 
            


<210>  700
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  700

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Met His Gly Ser 
385                 390                 395                 400 


Leu Leu Gln Glu Lys His Arg Ile Leu His Lys Leu Leu Gln Asn Gly 
                405                 410                 415     


Asn Ser Pro Ala Glu Val Ala Lys Ile Thr Ala Glu Ala Thr Gly Lys 
            420                 425                 430         


Asp Thr Ser Ser Ile Thr Ser Cys Gly Asp Gly Asn Val Val Lys Gln 
        435                 440                 445             


Glu Gln Leu Ser Pro Lys Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr 
    450                 455                 460                 


Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly Ser 
465                 470                 475     


<210>  701
<211>  476
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  701

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Pro Lys Lys Glu 
385                 390                 395                 400 


Asn Asn Ala Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp 
                405                 410                 415     


Ala Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Lys Glu Asn Asn Ala 
            420                 425                 430         


Leu Leu Arg Tyr Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Ser Lys Lys Glu Asn Asn Ala Leu Leu Arg Tyr 
    450                 455                 460                 


Leu Leu Asp Arg Asp Asp Pro Ser Asp Ala Gly Ser 
465                 470                 475     


<210>  702
<211>  775
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  702

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu 
    130                 135                 140                 


Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg 
145                 150                 155                 160 


Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr 
                165                 170                 175     


Asp Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His 
            180                 185                 190         


Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe 
        195                 200                 205             


Gln Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu 
    210                 215                 220                 


Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln 
225                 230                 235                 240 


Val Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu 
                245                 250                 255     


Ala Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly 
            260                 265                 270         


Phe Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp 
        275                 280                 285             


Phe Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu 
    290                 295                 300                 


Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser 
305                 310                 315                 320 


Gly Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln 
                325                 330                 335     


Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro 
            340                 345                 350         


Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu 
        355                 360                 365             


Arg Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys 
    370                 375                 380                 


Thr Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys 
385                 390                 395                 400 


Asp Leu Tyr Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys 
                405                 410                 415     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            420                 425                 430         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        435                 440                 445             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    450                 455                 460                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
465                 470                 475                 480 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                485                 490                 495     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            500                 505                 510         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Arg Gly 
        515                 520                 525             


Ser Gly Ser Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Asp Asn 
    530                 535                 540                 


Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly 
545                 550                 555                 560 


Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg 
                565                 570                 575     


Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly 
            580                 585                 590         


Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly 
        595                 600                 605             


Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys 
    610                 615                 620                 


Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu 
625                 630                 635                 640 


Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly 
                645                 650                 655     


Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp 
            660                 665                 670         


Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu 
        675                 680                 685             


Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg 
    690                 695                 700                 


Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr 
705                 710                 715                 720 


Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn 
                725                 730                 735     


Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu 
            740                 745                 750         


Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu 
        755                 760                 765             


Leu Tyr Lys Cys Val Thr Asp 
    770                 775 


<210>  703
<211>  297
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  703

Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp Asp 
1               5                   10                  15      


Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala Ala 
            20                  25                  30          


Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser 
        35                  40                  45              


Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp 
    50                  55                  60                  


Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe 
65                  70                  75                  80  


Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu 
                85                  90                  95      


Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp 
            100                 105                 110         


Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu 
        115                 120                 125             


Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys 
    130                 135                 140                 


Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys 
145                 150                 155                 160 


Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser 
                165                 170                 175     


Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys 
            180                 185                 190         


Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr 
        195                 200                 205             


Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys 
    210                 215                 220                 


Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu 
225                 230                 235                 240 


Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His 
                245                 250                 255     


Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys 
            260                 265                 270         


Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu Asp 
        275                 280                 285             


Ala His Arg Leu His Ala Pro Thr Ser 
    290                 295         


<210>  704
<211>  297
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  704

Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp Asp 
1               5                   10                  15      


Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala Ala 
            20                  25                  30          


Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser 
        35                  40                  45              


Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp 
    50                  55                  60                  


Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe 
65                  70                  75                  80  


Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu 
                85                  90                  95      


Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp 
            100                 105                 110         


Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu 
        115                 120                 125             


Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys 
    130                 135                 140                 


Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys 
145                 150                 155                 160 


Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser 
                165                 170                 175     


Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys 
            180                 185                 190         


Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr 
        195                 200                 205             


Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys 
    210                 215                 220                 


Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu 
225                 230                 235                 240 


Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His 
                245                 250                 255     


Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys 
            260                 265                 270         


Cys Lys Asn Val Val Pro Leu Phe Asp Leu Leu Leu Glu Met Leu Asp 
        275                 280                 285             


Ala His Arg Leu His Ala Pro Thr Ser 
    290                 295         


<210>  705
<211>  297
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  705

Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp Asp 
1               5                   10                  15      


Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala Ala 
            20                  25                  30          


Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser 
        35                  40                  45              


Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp 
    50                  55                  60                  


Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe 
65                  70                  75                  80  


Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu 
                85                  90                  95      


Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp 
            100                 105                 110         


Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu 
        115                 120                 125             


Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly Lys 
    130                 135                 140                 


Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys 
145                 150                 155                 160 


Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser 
                165                 170                 175     


Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys 
            180                 185                 190         


Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr 
        195                 200                 205             


Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys 
    210                 215                 220                 


Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu 
225                 230                 235                 240 


Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His 
                245                 250                 255     


Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu Tyr Ser Met Lys 
            260                 265                 270         


Cys Lys Asn Val Val Pro Leu Phe Asp Leu Leu Leu Glu Met Leu Asp 
        275                 280                 285             


Ala His Arg Leu His Ala Pro Thr Ser 
    290                 295         


<210>  706
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  706

Ser Gly Ser Gly Pro Gly Ser Arg Glu Trp Phe Lys Asp Met Leu Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Ser Gly Ser Gly Pro Gly Ser Arg Glu 
            20                  25                  30          


Trp Phe Lys Asp Met Leu Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly 
        35                  40                  45              


Ser Gly Pro Gly Ser Arg Glu Trp Phe Lys Asp Met 
    50                  55                  60  


<210>  707
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  707

Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala Phe Gln Leu Arg Gln Leu 
            20                  25                  30          


Ile Leu Arg Gly Leu Gln Asp Asp Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp 
    50                  55                  60                  


<210>  708
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  708

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Ser Gly Ser Gly 
385                 390                 395                 400 


Pro Gly Ser Arg Glu Trp Phe Lys Asp Met Leu Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Ser Ser Gly Ser Gly Pro Gly Ser Arg Glu Trp Phe Lys Asp 
            420                 425                 430         


Met Leu Gly Gly Gly Ser Gly Gly Gly Ser Ser Gly Ser Gly Pro Gly 
        435                 440                 445             


Ser Arg Glu Trp Phe Lys Asp Met Leu Gly Ser 
    450                 455                 


<210>  709
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  709

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Asp Ala Phe Gln 
385                 390                 395                 400 


Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Ser Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly 
            420                 425                 430         


Leu Gln Asp Asp Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala Phe Gln 
        435                 440                 445             


Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Ser 
    450                 455                 460         


<210>  710
<211>  801
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  710

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
    130                 135                 140                 


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
145                 150                 155                 160 


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
                165                 170                 175     


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
            180                 185                 190         


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
        195                 200                 205             


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
    210                 215                 220                 


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
225                 230                 235                 240 


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
                245                 250                 255     


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
            260                 265                 270         


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
        275                 280                 285             


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
    290                 295                 300                 


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
305                 310                 315                 320 


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
                325                 330                 335     


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
            340                 345                 350         


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
        355                 360                 365             


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
    370                 375                 380                 


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
385                 390                 395                 400 


Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu 
                405                 410                 415     


Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        435                 440                 445             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    450                 455                 460                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
465                 470                 475                 480 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                485                 490                 495     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Ala Leu Pro Pro Arg Ser Arg Gly Ser Gly Ser Gly Ser Gly 
545                 550                 555                 560 


Ser Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
                565                 570                 575     


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
            580                 585                 590         


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln 
        595                 600                 605             


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
    610                 615                 620                 


Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys 
625                 630                 635                 640 


His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly 
                645                 650                 655     


Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr 
            660                 665                 670         


Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val 
        675                 680                 685             


Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys 
    690                 695                 700                 


Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp 
705                 710                 715                 720 


Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly 
                725                 730                 735     


Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro 
            740                 745                 750         


Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr 
        755                 760                 765             


Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu 
    770                 775                 780                 


Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Cys Val Thr 
785                 790                 795                 800 


Asp 
    


<210>  711
<211>  801
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  711

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
    130                 135                 140                 


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
145                 150                 155                 160 


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
                165                 170                 175     


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
            180                 185                 190         


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
        195                 200                 205             


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
    210                 215                 220                 


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
225                 230                 235                 240 


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
                245                 250                 255     


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
            260                 265                 270         


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
        275                 280                 285             


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
    290                 295                 300                 


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
305                 310                 315                 320 


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
                325                 330                 335     


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
            340                 345                 350         


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
        355                 360                 365             


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
    370                 375                 380                 


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
385                 390                 395                 400 


Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Phe Asp Leu Leu Leu 
                405                 410                 415     


Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        435                 440                 445             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    450                 455                 460                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
465                 470                 475                 480 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                485                 490                 495     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Ala Leu Pro Pro Arg Ser Arg Gly Ser Gly Ser Gly Ser Gly 
545                 550                 555                 560 


Ser Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
                565                 570                 575     


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
            580                 585                 590         


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln 
        595                 600                 605             


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
    610                 615                 620                 


Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys 
625                 630                 635                 640 


His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly 
                645                 650                 655     


Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr 
            660                 665                 670         


Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val 
        675                 680                 685             


Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys 
    690                 695                 700                 


Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp 
705                 710                 715                 720 


Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly 
                725                 730                 735     


Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro 
            740                 745                 750         


Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr 
        755                 760                 765             


Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu 
    770                 775                 780                 


Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Cys Val Thr 
785                 790                 795                 800 


Asp 
    


<210>  712
<211>  801
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  712

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
    130                 135                 140                 


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
145                 150                 155                 160 


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
                165                 170                 175     


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
            180                 185                 190         


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
        195                 200                 205             


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
    210                 215                 220                 


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
225                 230                 235                 240 


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
                245                 250                 255     


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
            260                 265                 270         


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
        275                 280                 285             


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
    290                 295                 300                 


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
305                 310                 315                 320 


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
                325                 330                 335     


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
            340                 345                 350         


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
        355                 360                 365             


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
    370                 375                 380                 


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu 
385                 390                 395                 400 


Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Phe Asp Leu Leu Leu 
                405                 410                 415     


Glu Met Leu Asp Ala His Arg Leu His Ala Pro Thr Ser Gly Ser Gly 
            420                 425                 430         


Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        435                 440                 445             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    450                 455                 460                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
465                 470                 475                 480 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                485                 490                 495     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            500                 505                 510         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        515                 520                 525             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    530                 535                 540                 


Met Gln Ala Leu Pro Pro Arg Ser Arg Gly Ser Gly Ser Gly Ser Gly 
545                 550                 555                 560 


Ser Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
                565                 570                 575     


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
            580                 585                 590         


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln 
        595                 600                 605             


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
    610                 615                 620                 


Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys 
625                 630                 635                 640 


His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly 
                645                 650                 655     


Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr 
            660                 665                 670         


Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val 
        675                 680                 685             


Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys 
    690                 695                 700                 


Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp 
705                 710                 715                 720 


Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly 
                725                 730                 735     


Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro 
            740                 745                 750         


Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr 
        755                 760                 765             


Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu 
    770                 775                 780                 


Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Cys Val Thr 
785                 790                 795                 800 


Asp 
    


<210>  713
<211>  781
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  713

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
    130                 135                 140                 


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
145                 150                 155                 160 


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
                165                 170                 175     


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
            180                 185                 190         


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
        195                 200                 205             


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
    210                 215                 220                 


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
225                 230                 235                 240 


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
                245                 250                 255     


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
            260                 265                 270         


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
        275                 280                 285             


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
    290                 295                 300                 


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
305                 310                 315                 320 


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
                325                 330                 335     


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
            340                 345                 350         


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
        355                 360                 365             


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
    370                 375                 380                 


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
385                 390                 395                 400 


Tyr Ser Met Lys Cys Lys Asn Val Ala Gly Ser Gly Ser Gly Ser Gly 
                405                 410                 415     


Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             


Pro Pro Arg Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Val Ser 
    530                 535                 540                 


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
545                 550                 555                 560 


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
                565                 570                 575     


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
            580                 585                 590         


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
        595                 600                 605             


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
    610                 615                 620                 


Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
625                 630                 635                 640 


Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp 
                645                 650                 655     


Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly 
            660                 665                 670         


Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
        675                 680                 685             


Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys 
    690                 695                 700                 


Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp 
705                 710                 715                 720 


Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro 
                725                 730                 735     


Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu 
            740                 745                 750         


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser 
        755                 760                 765             


Thr Gly Gly Met Asp Glu Leu Tyr Lys Cys Val Thr Asp 
    770                 775                 780     


<210>  714
<211>  781
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  714

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg 
    130                 135                 140                 


Gln Arg Asp Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp 
145                 150                 155                 160 


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
                165                 170                 175     


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
            180                 185                 190         


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
        195                 200                 205             


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
    210                 215                 220                 


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
225                 230                 235                 240 


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
                245                 250                 255     


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
            260                 265                 270         


His Pro Gly Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
        275                 280                 285             


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
    290                 295                 300                 


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
305                 310                 315                 320 


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
                325                 330                 335     


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
            340                 345                 350         


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
        355                 360                 365             


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
    370                 375                 380                 


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Arg Met Glu His Leu 
385                 390                 395                 400 


Tyr Ser Met Lys Cys Lys Asn Val Ala Gly Ser Gly Ser Gly Ser Gly 
                405                 410                 415     


Ser Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            420                 425                 430         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        435                 440                 445             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    450                 455                 460                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
465                 470                 475                 480 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                485                 490                 495     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            500                 505                 510         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        515                 520                 525             


Pro Pro Arg Ser Arg Gly Ser Gly Ser Gly Ser Gly Ser Met Val Ser 
    530                 535                 540                 


Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe 
545                 550                 555                 560 


Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu 
                565                 570                 575     


Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu 
            580                 585                 590         


Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser 
        595                 600                 605             


Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp 
    610                 615                 620                 


Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu 
625                 630                 635                 640 


Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp 
                645                 650                 655     


Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly 
            660                 665                 670         


Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly 
        675                 680                 685             


Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys 
    690                 695                 700                 


Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp 
705                 710                 715                 720 


Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro 
                725                 730                 735     


Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu 
            740                 745                 750         


Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser 
        755                 760                 765             


Thr Gly Gly Met Asp Glu Leu Tyr Lys Cys Val Thr Asp 
    770                 775                 780     


<210>  715
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  715

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Pro Arg Gln Gly 
385                 390                 395                 400 


Ser Ile Leu Tyr Ser Met Leu Thr Ser Ala Lys Gln Thr Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Ser Pro Arg Gln Gly Ser Ile Leu Tyr Ser Met Leu 
            420                 425                 430         


Thr Ser Ala Lys Gln Thr Gly Gly Gly Ser Gly Gly Gly Ser Pro Arg 
        435                 440                 445             


Gln Gly Ser Ile Leu Tyr Ser Met Leu Thr Ser Ala Lys Gln Thr Gly 
    450                 455                 460                 


Ser 
465 


<210>  716
<211>  471
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  716

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Leu Thr Glu Arg 
385                 390                 395                 400 


His Lys Ile Leu His Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Gly 
                405                 410                 415     


Gly Gly Ser Gly Gly Gly Ser Leu Thr Glu Arg His Lys Ile Leu His 
            420                 425                 430         


Arg Leu Leu Gln Glu Gly Ser Pro Ser Asp Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Ser Leu Thr Glu Arg His Lys Ile Leu His Arg Leu Leu Gln Glu 
    450                 455                 460                 


Gly Ser Pro Ser Asp Gly Ser 
465                 470     


<210>  717
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  717

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Ser Lys Gly Gln 
385                 390                 395                 400 


Thr Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Ser Ser Lys Gly Gln Thr Lys Leu Leu Gln Leu Leu 
            420                 425                 430         


Thr Thr Lys Ser Asp Gln Gly Gly Gly Ser Gly Gly Gly Ser Ser Lys 
        435                 440                 445             


Gly Gln Thr Lys Leu Leu Gln Leu Leu Thr Thr Lys Ser Asp Gln Gly 
    450                 455                 460                 


Ser 
465 


<210>  718
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  718

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Ala Glu Glu Pro 
385                 390                 395                 400 


Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Ser Ala Glu Glu Pro Ser Leu Leu Lys Lys Leu Leu 
            420                 425                 430         


Leu Ala Pro Ala Asn Thr Gly Gly Gly Ser Gly Gly Gly Ser Ala Glu 
        435                 440                 445             


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gly 
    450                 455                 460                 


Ser 
465 


<210>  719
<211>  465
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  719

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Ala Ala Asn Asn 
385                 390                 395                 400 


Ser Leu Leu Leu His Leu Leu Lys Ser Gln Thr Ile Pro Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Ser Ala Ala Asn Asn Ser Leu Leu Leu His Leu Leu 
            420                 425                 430         


Lys Ser Gln Thr Ile Pro Gly Gly Gly Ser Gly Gly Gly Ser Ala Ala 
        435                 440                 445             


Asn Asn Ser Leu Leu Leu His Leu Leu Lys Ser Gln Thr Ile Pro Gly 
    450                 455                 460                 


Ser 
465 


<210>  720
<211>  820
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  720

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Val Lys Cys Gly Ser Arg Arg Glu Arg Cys Gly Tyr 
    130                 135                 140                 


Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His Cys Ala 
145                 150                 155                 160 


Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg Glu Leu 
                165                 170                 175     


Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu Leu Glu 
            180                 185                 190         


Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro Phe Thr 
        195                 200                 205             


Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys Glu Leu 
    210                 215                 220                 


Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu 
225                 230                 235                 240 


Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met Glu Val 
                245                 250                 255     


Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly Lys Leu 
            260                 265                 270         


Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys Cys Val 
        275                 280                 285             


Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr Ser Arg 
    290                 295                 300                 


Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val Lys Ala 
305                 310                 315                 320 


Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala Thr Gln 
                325                 330                 335     


Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala Val Thr 
            340                 345                 350         


Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser Gln Gln 
        355                 360                 365             


Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His Val Arg 
    370                 375                 380                 


His Ala Ser Asn Lys Gly Met Glu His Leu Leu Asn Met Lys Cys Lys 
385                 390                 395                 400 


Asn Val Val Pro Val Tyr Asp Leu Leu Leu Glu Met Leu Asn Ala His 
                405                 410                 415     


Val Leu Arg Gly Cys Lys Ser Ser Ile Thr Gly Ser Glu Cys Ser Pro 
            420                 425                 430         


Ala Glu Asp Ser Lys Ser Lys Glu Gly Ser Gln Asn Pro Gln Ser Gln 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg 
    450                 455                 460                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                485                 490                 495     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            500                 505                 510         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        515                 520                 525             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    530                 535                 540                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
545                 550                 555                 560 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Arg Gly Ser Gly Ser 
                565                 570                 575     


Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile 
            580                 585                 590         


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn 
        595                 600                 605             


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
    610                 615                 620                 


Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro 
625                 630                 635                 640 


Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala 
                645                 650                 655     


Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe 
            660                 665                 670         


Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 
        675                 680                 685             


Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile 
    690                 695                 700                 


Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val 
705                 710                 715                 720 


Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr 
                725                 730                 735     


Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu 
            740                 745                 750         


Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala 
        755                 760                 765             


Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu 
    770                 775                 780                 


Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu 
785                 790                 795                 800 


Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                805                 810                 815     


Cys Val Thr Asp 
            820 


<210>  721
<211>  456
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  721

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Gln Ala Gln Gln 
385                 390                 395                 400 


Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Ser Gln Ala Gln Gln Lys Ser Leu Leu Gln Gln Leu Leu Thr Glu 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Ser Gln Ala Gln Gln Lys Ser Leu Leu 
        435                 440                 445             


Gln Gln Leu Leu Thr Glu Gly Ser 
    450                 455     


<210>  722
<211>  462
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  722

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys Leu Leu 
            340                 345                 350         


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
        355                 360                 365             


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
    370                 375                 380                 


Glu Leu Ser Arg Gly Ser Gly Ser Gly Ser Thr Ser Asp Ala Phe Gln 
385                 390                 395                 400 


Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Ser Asp Ala Phe Gln Leu Arg Gln Leu Ile Leu Arg Gly 
            420                 425                 430         


Leu Gln Asp Asp Gly Gly Gly Ser Gly Gly Gly Ser Asp Ala Phe Gln 
        435                 440                 445             


Leu Arg Gln Leu Ile Leu Arg Gly Leu Gln Asp Asp Gly Ser 
    450                 455                 460         


<210>  723
<211>  820
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic amino acid sequence

<400>  723

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
    50                  55                  60                  


Ser Leu Val Ile Thr Leu Tyr Cys Ser Leu Lys Arg Gly Arg Lys Lys 
65                  70                  75                  80  


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
                85                  90                  95      


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
            100                 105                 110         


Gly Cys Glu Leu Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Thr Ser Val Lys Cys Gly Ser Arg Arg Glu Arg Cys Gly Tyr 
    130                 135                 140                 


Arg Leu Val Arg Arg Gln Arg Ser Ala Asp Glu Gln Leu His Cys Ala 
145                 150                 155                 160 


Gly Lys Ala Lys Arg Ser Gly Gly His Ala Pro Arg Val Arg Glu Leu 
                165                 170                 175     


Leu Leu Asp Ala Leu Ser Pro Glu Gln Leu Val Leu Thr Leu Leu Glu 
            180                 185                 190         


Ala Glu Pro Pro His Val Leu Ile Ser Arg Pro Ser Ala Pro Phe Thr 
        195                 200                 205             


Glu Ala Ser Met Met Met Ser Leu Thr Lys Leu Ala Asp Lys Glu Leu 
    210                 215                 220                 


Val His Met Ile Ser Trp Ala Lys Lys Ile Pro Gly Phe Val Glu Leu 
225                 230                 235                 240 


Ser Leu Phe Asp Gln Val Arg Leu Leu Glu Ser Cys Trp Met Glu Val 
                245                 250                 255     


Leu Met Met Gly Leu Met Trp Arg Ser Ile Asp His Pro Gly Lys Leu 
            260                 265                 270         


Ile Phe Ala Pro Asp Leu Val Leu Asp Arg Asp Glu Gly Lys Cys Val 
        275                 280                 285             


Glu Gly Ile Leu Glu Ile Phe Asp Met Leu Leu Ala Thr Thr Ser Arg 
    290                 295                 300                 


Phe Arg Glu Leu Lys Leu Gln His Lys Glu Tyr Leu Cys Val Lys Ala 
305                 310                 315                 320 


Met Ile Leu Leu Asn Ser Ser Met Tyr Pro Leu Val Thr Ala Thr Gln 
                325                 330                 335     


Asp Ala Asp Ser Ser Arg Lys Leu Ala His Leu Leu Asn Ala Val Thr 
            340                 345                 350         


Asp Ala Leu Val Trp Val Ile Ala Lys Ser Gly Ile Ser Ser Gln Gln 
        355                 360                 365             


Gln Ser Met Arg Leu Ala Asn Leu Leu Met Leu Leu Ser His Val Arg 
    370                 375                 380                 


His Ala Ser Asn Lys Gly Met Glu His Leu Leu Asn Met Lys Cys Lys 
385                 390                 395                 400 


Asn Val Val Pro Val Tyr Asp Leu Leu Leu Glu Met Leu Asn Ala His 
                405                 410                 415     


Val Leu Arg Gly Cys Lys Ser Ser Ile Thr Gly Ser Glu Cys Ser Pro 
            420                 425                 430         


Ala Glu Asp Ser Lys Ser Lys Glu Gly Ser Gln Asn Pro Gln Ser Gln 
        435                 440                 445             


Gly Ser Gly Ser Gly Ser Gly Ser Ser Leu Arg Val Lys Phe Ser Arg 
    450                 455                 460                 


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                485                 490                 495     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            500                 505                 510         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        515                 520                 525             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    530                 535                 540                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
545                 550                 555                 560 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Arg Gly Ser Gly Ser 
                565                 570                 575     


Gly Ser Gly Ser Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile 
            580                 585                 590         


Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn 
        595                 600                 605             


Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu 
    610                 615                 620                 


Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro 
625                 630                 635                 640 


Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala 
                645                 650                 655     


Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe 
            660                 665                 670         


Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly 
        675                 680                 685             


Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile 
    690                 695                 700                 


Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val 
705                 710                 715                 720 


Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr 
                725                 730                 735     


Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu 
            740                 745                 750         


Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala 
        755                 760                 765             


Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu 
    770                 775                 780                 


Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu 
785                 790                 795                 800 


Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
                805                 810                 815     


Cys Val Thr Asp 
            820 


