                         SEQUENCE LISTING

<110>  ModernaTX, Inc.
 
<120>  THERAPEUTIC MRNAS ENCODING ANTI CTLA-4 ANTIBODIES

<130>  3529.061PC06

<150>  US 62/276,958
<151>  2016-01-10

<150>  US 62/276,959
<151>  2016-01-10

<150>  US 62/290,436
<151>  2016-02-02

<150>  US 62/290,435
<151>  2016-02-02

<160>  325   

<170>  PatentIn version 3.5

<210>  1
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  2
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  3
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Phe Leu 
        115                 120                 125             


Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe Tyr Ser Phe 
    130                 135                 140                 


Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys Arg Ser Pro 
145                 150                 155                 160 


Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu Pro Glu Cys 
                165                 170                 175     


Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
            180                 185             


<210>  4
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Pro Pro Thr Glu Pro Glu Cys Glu Lys Gln Phe 
        35                  40                  45              


Gln Pro Tyr Phe Ile Pro Ile Asn 
    50                  55      


<210>  5
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Lys Glu Lys Lys Pro Ser Tyr Asn Arg Gly Leu 
        35                  40                  45              


Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
    50                  55              


<210>  6
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Ser Lys Glu Lys Lys Pro Ser 
    50                  55                  60                  


Tyr Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
65                  70                  75                  


<210>  7
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Ala Lys Glu Lys Lys Pro Ser Tyr 
145                 150                 155                 160 


Asn Arg Gly Leu Cys Glu Asn Ala Pro Asn Arg Ala Arg Met 
                165                 170                 


<210>  8
<211>  503
<212>  DNA
<213>  Homo sapiens

<400>  8
ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccttc       60

agtagctatg gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca      120

gttatatggt atgatggaag taataaatac tatgcagact ccgtgaaggg ccgattcacc      180

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag      240

gacacggctg tgtattactg tgcgagagat ccgaggggag ctacccttta ctactactac      300

taccggtkgg acgtctgggg ccaagggacc acggtcaccg tctcctcagc ctccaccaag      360

ggcccatcgg tcttccccct ggcgccctgc tccaggagca cctccgagag cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gctctgacca gcggcgtgca cac                                              503


<210>  9
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu 
                85                  90                  95      


Tyr Tyr Tyr Tyr Tyr Arg Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His 
                165     


<210>  10
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  10
ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgccg ggcaagtcag       60

agcattaaca gctatttaga ttggtatcag cagaaaccag ggaaagcccc taaactcctg      120

atctatgctg catccagttt gcaaagtggg gtcccatcaa ggttcagtgg cagtggatct      180

gggacagatt tcactctcac catcagcagt ctgcaacctg aagattttgc aacttactac      240

tgtcaacagt attacagtac tccattcact ttcggccctg ggaccaaagt ggaaatcaaa      300

cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct      360

ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagta         417


<210>  11
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 


<210>  12
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu 
                85                  90                  95      


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His 
                165         


<210>  13
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  13

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 


<210>  14
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  16
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp 
1               5                   10      


<210>  18
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  20
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  20
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgcagcgt ctggattcac cttcagtagc tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagtaataa atactatgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agatccgagg      360

ggagctaccc tttactacta ctactacggt atggacgtct ggggccaagg gaccacggtc      420

accgtctcct cagcctccac caagggccca tcggtcttcc ccctggcgcc ctgctccagg      480

agcacctccg agagcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      540

gtgacggtgt cgtggaactc aggcgctctg accagcggcg tgcacacctt cccagctgtc      600

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcaacttc      660

ggcacccaga cctacacctg caacgtagat cacaagccca gcaacaccaa ggtggacaag      720

acagttgagc gcaaatgttg tgtcgagtgc ccaccgtgcc cagcaccacc tgtggcagga      780

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      840

gaggtcacgt gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcca gttcaactgg      900

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cacgggagga gcagttcaac      960

agcacgttcc gtgtggtcag cgtcctcacc gttgtgcacc aggactggct gaacggcaag     1020

gagtacaagt gcaaggtctc caacaaaggc ctcccagccc ccatcgagaa aaccatctcc     1080

aaaaccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1140

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     1200

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccatg     1260

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg     1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1380

cagaagagcc tctccctgtc tccgggtaaa tga                                  1413


<210>  21
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  22
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  22
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgtgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      120

gtcaccatca cttgccgggc aagtcagagc attaacagct atttagattg gtatcagcag      180

aaaccaggga aagcccctaa actcctgatc tatgctgcat ccagtttgca aagtggggtc      240

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg      300

caacctgaag attttgcaac ttactactgt caacagtatt acagtactcc attcactttc      360

ggccctggga ccaaagtgga aatcaaacga actgtggctg caccatctgt cttcatcttc      420

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac      480

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac      540

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc      600

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat      660

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta gtga            714


<210>  23
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  24
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  24
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgtagcgt ctggattcac cttcagtagc catggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagaaataa atactatgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtttctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggaggtcac      360

ttcggtcctt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc      420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt      720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc      960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

ccgggtaaat ga                                                         1392


<210>  25
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser His Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly His Phe Gly Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  26
<211>  708
<212>  DNA
<213>  Homo sapiens

<400>  26
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca gggccagtca gagtattagc agcagcttct tagcctggta ccagcagaga      180

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      240

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      300

cctgaagatt ttgcagtgta ttactgtcag cagtatggta cctcaccctg gacgttcggc      360

caagggacca aggtggaaat caaacgaact gtggctgcac catctgtctt catcttcccg      420

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      480

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      540

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      600

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      660

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgttag                   708


<210>  27
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Ser Ser Ser Phe Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Thr Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  28
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser His Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly His Phe Gly Pro Phe 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln 
                165         


<210>  29
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser Phe Leu Ala Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        35                  40                  45              


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Trp Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140     


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Phe Thr Phe Ser Ser His Gly Met His 
1               5                   10  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Gly His Phe Gly Pro Phe Asp Tyr 
1               5                   


<210>  33
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Ala Ser Gln Ser Ile Ser Ser Ser Phe Leu Ala 
1               5                   10          


<210>  34
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  35
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  35

Cys Gln Gln Tyr Gly Thr Ser Pro Trp Thr 
1               5                   10  


<210>  36
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  36
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtgtagcgt ctggattcac cttcagtagc catggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagaaataa atactatgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtttctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggaggtcac      360

ttcggtcctt ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc      420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt      720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc acgggaggag cagttccaaa gcacgttccg tgtggtcagc      960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

ccgggtaaat ga                                                         1392


<210>  37
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser His Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly His Phe Gly Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  38
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  38
cctgggaggt ccctgagact ctcctgtgca gcgtctggat tcaccttcag tagtcatggc       60

atccactggg tccgccaggc tccaggcaag gggctggagt gggtggcagt tatatggtat      120

gatggaagaa ataaagacta tgcagactcc gtgaagggcc gattcaccat ctccagagac      180

aattccaaga acacgctgta tttgcaaatg aacagcctga gagccgagga cacggctgtg      240

tattactgtg cgagagtggc cccactgggg ccacttgact actggggcca gggaaccctg      300

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tccccctggc gccctgctcc      360

aggagcacct ccgagagcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      420

ccggtgacgg tgtcgtggaa ctcaggcgct ctgaccagc                             459


<210>  39
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  39

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150             


<210>  40
<211>  440
<212>  DNA
<213>  Homo sapiens

<400>  40
cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc       60

agtcagagtg tcagcagcta cttagcctgg taccagcaga aacctggcca ggctcccagg      120

ctcctcatct atggtgcatc cagcagggcc actggcatcc cagacaggtt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgagga ttttgcagtg      240

tattactgtc aacagtatgg taggtcacca ttcactttcg gccctgggac caaagtagat      300

atcaagcgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      360

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      420

gtacagtgga aaggtggata                                                  440


<210>  41
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  41

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Gly Gly 
145     


<210>  42
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  42

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150             


<210>  43
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Gly Gly 
145     


<210>  44
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Phe Thr Phe Ser Ser His Gly Ile His 
1               5                   10  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  46
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Ala Pro Leu Gly Pro Leu Asp Tyr 
1               5                   


<210>  47
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  47

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  48
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr 
1               5                   10  


<210>  50
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  50
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtccagcctg ggaggtccct gagactctcc      120

tgtacagcgt ctggattcac cttcagtaac tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagtaataa acactatgga      240

gactccgtga agggccgatt caccatctcc agtgacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggagagaga      360

ctggggtcct actttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagcctcc      420

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca      480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac      540

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc      600

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc      660

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt      720

tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc      780

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      840

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag      900

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc      960

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc     1020

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc     1080

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc     1140

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1200

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc     1260

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1320

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1380

tctccgggta aatga                                                      1395


<210>  51
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Gly 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Glu Arg Leu Gly Ser Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  52
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  52
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgca ggaccagtgt tagcagcagt tacttagcct ggtaccagca gaaacctggc      180

caggctccca ggctcctcat ctatggtgca tccagcaggg ccactggcat cccagacagg      240

ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa      300

gattttgcag tctattactg tcagcagtat ggcatctcac ccttcacttt cggcggaggg      360

accaaggtgg agatcaagcg aactgtggct gcaccatctg tcttcatctt cccgccatct      420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      660

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt ag                         702


<210>  53
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Thr Ser Val Ser 
        35                  40                  45              


Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ile 
            100                 105                 110         


Ser Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  54
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Asn Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys His Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ser Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Glu Arg Leu Gly Ser Tyr 
                85                  90                  95      


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val 
                165     


<210>  55
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  55

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Thr Ser Val Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg 
        35                  40                  45              


Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    50                  55                  60                  


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
65                  70                  75                  80  


Tyr Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            100                 105                 110         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        115                 120                 125             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140     


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Gly Phe Thr Phe Ser Asn Tyr Gly Met His 
1               5                   10  


<210>  57
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Gly Asp Ser Val 
1               5                   10                  15  


<210>  58
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Glu Arg Leu Gly Ser Tyr Phe Asp Tyr 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  59

Arg Thr Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10  


<210>  60
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  61
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  61

Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr 
1               5                   10  


<210>  62
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  62
cctgggaggt ccctgagact ctcctgtgca gcgtctggat tcaccttcag tagtcatggc       60

atccactggg tccgccaggc tccaggcaag gggctggagt gggtggcagt tatatggtat      120

gatggaagaa ataaagacta tgcagactcc gtgaagggcc gattcaccat ctccagagac      180

aattccaaga agacgctgta tttgcaaatg aacagcctga gagccgagga cacggctgtg      240

tattactgtg cgagagtggc cccactgggg ccacttgact actggggcca gggaaccctg      300

gtcaccgtct cctcagcctc caccaagggc ccatcggtct tccccctggc gccctgctcc      360

aggagcacct ccgagagcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      420

ccggtgacgg tgtcgtggaa ctcaggcgct ctgaccagcg gcgtgcacac cttcccagct      480

gtcctacag                                                              489


<210>  63
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  63

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
145                 150                 155                 160 


Val Leu Gln 
            


<210>  64
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  64
ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt       60

gtcagcagct acttagcctg gtaccagcag aaacctggcc aggctcccag actcctcatc      120

tatggtgcat ccagcagggc cactggcatc ccagacaggt tcagtggcag tgggtctggg      180

acagacttca ctctcaccat cagcagactg gagcctgagg attttgcagt gtattactgt      240

cagcagtatg gtaggtcacc attcactttc ggccctggga ccaaagtgga tatcaagcga      300

actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga      360

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacag         417


<210>  65
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            20                  25                  30          


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
        35                  40                  45              


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    50                  55                  60                  


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
65                  70                  75                  80  


Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
                85                  90                  95      


Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        115                 120                 125             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 


<210>  66
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  66

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Lys 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
145                 150                 155                 160 


Val Leu Gln 
            


<210>  67
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
1               5                   10                  15      


Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            20                  25                  30          


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr 
        35                  40                  45              


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    50                  55                  60                  


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
65                  70                  75                  80  


Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly Thr Lys Val 
                85                  90                  95      


Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
            100                 105                 110         


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
        115                 120                 125             


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 


<210>  68
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  68

Gly Phe Thr Phe Ser Ser His Gly Ile His 
1               5                   10  


<210>  69
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  69

Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  70
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  70

Val Ala Pro Leu Gly Pro Leu Asp Tyr 
1               5                   


<210>  71
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  71

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  72
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  72

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  73
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  73

Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr 
1               5                   10  


<210>  74
<211>  1392
<212>  DNA
<213>  Homo sapiens

<400>  74
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtcag       60

gtgcagctgg tggagtctgg gggaggcgtg gtcgagcctg ggaggtccct gagactctcc      120

tgtacagcgt ctggattcac cttcagtagt tatggcatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tggtatgatg gaagcaataa acactatgca      240

gactccgcga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctg      300

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agccggactg      360

ctgggttact ttgactactg gggccaggga accctggtca ccgtctcctc agcctccacc      420

aagggcccat cggtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      540

ggcgctctga ccagcggcgt gcacaccttc ccagctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcaacttcg gcacccagac ctacacctgc      660

aacgtagatc acaagcccag caacaccaag gtggacaaga cagttgagcg caaatgttgt      720

gtcgagtgcc caccgtgccc agcaccacct gtggcaggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      840

gacgtgagcc acgaagaccc cgaggtccag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc acgggaggag cagttcaaca gcacgttccg tgtggtcagc      960

gtcctcaccg ttgtgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1020

aacaaaggcc tcccagcccc catcgagaaa accatctcca aaaccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatcc cgggaggaga tgaccaagaa ccaggtcagc     1140

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccaca cctcccatgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

ccgggtaaat ga                                                         1392


<210>  75
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Glu 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala 
65                  70                  75                  80  


Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Gly Leu Leu Gly Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
225                 230                 235                 240 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210>  76
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  76
atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga taccaccgga       60

gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc      120

ctctcctgta gggccagtca aagtgttagc agctacttag cctggtacca acagaaacct      180

ggccaggctc ccaggcccct catctatggt gtatccagca gggccactgg catcccagac      240

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct      300

gaagattttg cagtgtatta ctgtcagcag tatggtatct caccattcac tttcggccct      360

gggaccaaag tggatatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                      705


<210>  77
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Pro Leu Ile Tyr Gly Val Ser Ser Arg Ala Thr Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 
            100                 105                 110         


Ile Ser Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  78
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  78

Gly Gly Val Val Glu Pro Gly Arg Ser Leu Arg Leu Ser Cys Thr Ala 
1               5                   10                  15      


Ser Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala 
            20                  25                  30          


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser 
        35                  40                  45              


Asn Lys His Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg 
    50                  55                  60                  


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
65                  70                  75                  80  


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Gly Leu Leu Gly Tyr 
                85                  90                  95      


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135             


<210>  79
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  79

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile Tyr Gly Val Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140         


<210>  80
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  81
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  81

Val Ile Trp Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Ala 
1               5                   10                  15  


<210>  82
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Gly Leu Leu Gly Tyr Phe Asp Tyr 
1               5                   


<210>  83
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  83

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  84
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  84

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  85
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  85

Cys Gln Gln Tyr Gly Ile Ser Pro Phe Thr 
1               5                   10  


<210>  86
<211>  507
<212>  DNA
<213>  Homo sapiens

<400>  86
ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccttc       60

agtagctatg gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca      120

gttatatggt atgatggaag taataaatac tatgcagact ccgtgaaggg ccgattcacc      180

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag      240

gacacggctg tgtattactg tgcgagaggg gcccgtataa taaccccttg tatggacgtc      300

tggggccaag ggaccacggt caccgtctcc tcagcctcca ccaagggccc atcggtcttc      360

cccctggcgc cctgctccag gagcacctcc gagagcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgctct gaccagcggc      480

gtgcacacct tcccagctgt cctacag                                          507


<210>  87
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  87

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Arg Ile Ile Thr Pro 
                85                  90                  95      


Cys Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
        115                 120                 125             


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln 
                165                 


<210>  88
<211>  458
<212>  DNA
<213>  Homo sapiens

<400>  88
cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca       60

agtcagagca ttaacaccta tttaatttgg tatcagcaga aaccagggaa agcccctaac      120

ttcctgatct ctgctacatc cattttgcaa agtggggtcc catcaaggtt ccgtggcagt      180

ggctctggga caaatttcac tctcaccatc aacagtcttc atcctgaaga ttttgcaact      240

tactactgtc aacagagtta cagtacccca ttcactttcg gccctgggac caaagtggat      300

atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      360

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      420

gtacagtgga aggtggataa cgccctccaa tcgggtaa                              458


<210>  89
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  89

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
1               5                   10                  15      


Thr Cys Arg Ala Ser Gln Ser Ile Asn Thr Tyr Leu Ile Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ala Pro Asn Phe Leu Ile Ser Ala Thr Ser Ile 
        35                  40                  45              


Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asn Phe Thr Leu Thr Ile Asn Ser Leu His Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Val Asp Asn Ala Leu Gln Ser Gly 
145                 150         


<210>  90
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  90

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Arg Ile Ile Thr Pro 
                85                  90                  95      


Cys Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
        115                 120                 125             


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln 
                165                 


<210>  91
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  91

Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
1               5                   10                  15      


Thr Cys Arg Ala Ser Gln Ser Ile Asn Thr Tyr Leu Ile Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Lys Ala Pro Asn Phe Leu Ile Ser Ala Thr Ser Ile 
        35                  40                  45              


Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asn Phe Thr Leu Thr Ile Asn Ser Leu His Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Val Asp Asn Ala Leu Gln Ser Gly 
145                 150         


<210>  92
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  92

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  93
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  93

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  94
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  94

Gly Ala Arg Ile Ile Thr Pro Cys Met Asp Val 
1               5                   10      


<210>  95
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  95

Arg Ala Ser Gln Ser Ile Asn Thr Tyr Leu Ile 
1               5                   10      


<210>  96
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  96

Ala Thr Ser Ile Leu Gln Ser 
1               5           


<210>  97
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  97

Gln Gln Ser Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  98
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  98
ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg tagcgtctgg attcatcttc       60

agtagtcatg gcatccactg ggtccgccag gctccaggca aggggctgga gtgggtggca      120

gttatatggt atgatggaag aaataaagac tatgcagact ccgtgaaggg ccgattcacc      180

atctccagag acaattccaa gaacacgctg tatttgcaaa tgaacagcct gagagccgag      240

gacacggctg tgtattactg tgcgagagtg gccccactgg ggccacttga ctactggggc      300

cagggaaccc tggtcaccgt ctcctcagcc tccaccaagg gcccatcggt cttccccctg      360

gcgccctgct ccaggagcac ctccgagagc acagcggccc tgggctgcct ggtcaaggac      420

tacttccccg aaccggtgac ggtgtcgtgg aactcaggcg ctctgaccag cggcgtgcac      480

accttcccag ctgtcctaca g                                                501


<210>  99
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  99

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser 
1               5                   10                  15      


Gly Phe Ile Phe Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn 
        35                  40                  45              


Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln 
                165         


<210>  100
<211>  426
<212>  DNA
<213>  Homo sapiens

<400>  100
tctccaggca ccctgtcttt gtctccaggg gaaagagcca ccctctcctg cagggccagt       60

cagagtatta gcagcaattt cttagcctgg taccagcaga aacctggcca ggctcccagg      120

ctcctcatct atcgtccatc cagcagggcc actggcatcc cagacagttt cagtggcagt      180

gggtctggga cagacttcac tctcaccatc agcagactgg agcctgagga ttttgcatta      240

tattactgtc agcagtatgg tacgtcacca ttcactttcg gccctgggac caaagtggat      300

atcaagcgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg      360

aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa      420

gtacag                                                                 426


<210>  101
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  101

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn Phe Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Pro Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Ser Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Leu 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140         


<210>  102
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  102

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser 
1               5                   10                  15      


Gly Phe Ile Phe Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn 
        35                  40                  45              


Lys Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln 
                165         


<210>  103
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  103

Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Ile Ser Ser Asn Phe Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Arg Pro Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Ser Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Leu 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
    130                 135                 140         


<210>  104
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly Phe Ile Phe Ser Ser His Gly Ile His 
1               5                   10  


<210>  105
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  105

Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  106
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  106

Val Ala Pro Leu Gly Pro Leu Asp Tyr 
1               5                   


<210>  107
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  107

Arg Ala Ser Gln Ser Ile Ser Ser Asn Phe Leu Ala 
1               5                   10          


<210>  108
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  108

Arg Pro Ser Ser Arg Ala Thr 
1               5           


<210>  109
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  109

Cys Gln Gln Tyr Gly Thr Ser Pro Phe Thr 
1               5                   10  


<210>  110
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  110
tcgggcccag gactggtgaa gccttcacag atcctgtccc tcacctgcac tgtctctggt       60

ggctccatca gcagtggtgg tcactactgg agctggatcc gccagcaccc agggaagggc      120

ctggagtgga ttgggtacat ctattacatt gggaacacct actacaaccc gtccctcaag      180

agtcgagtta ccatatcagt agacacgtct aagaaccagt tctccctgaa gctgagctct      240

gtgactgccg cggacacggc cgtgtattat tgtgcgagag atagtgggga ctactacggt      300

atagacgtct ggggccaagg gaccacggtc accgtctcct cagcttccac caagggccca      360

tccgtcttcc ccctggcgcc ctgctccagg agcacctccg agagcacagc cgccctgggc      420

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg      480

accagcggcg tgcacacctt cccggctgtc ctacaa                                516


<210>  111
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  111

Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ile Leu Ser Leu Thr Cys 
1               5                   10                  15      


Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Gly His Tyr Trp Ser Trp 
            20                  25                  30          


Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr 
        35                  40                  45              


Tyr Ile Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
    50                  55                  60                  


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
65                  70                  75                  80  


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly 
                85                  90                  95      


Asp Tyr Tyr Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170         


<210>  112
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  112
tctccagact ttcagtctgt gactccaaag gagaaagtca ccatcacctg ccgggccagt       60

cagagcattg gtagtagctt acattggtat cagcagaaac cagatcagtc tccaaagctc      120

ctcatcaagt atgcttccca gtccttctct ggggtcccct cgaggttcag tggcagtgga      180

tctgggacag atttcaccct caccatcaat agcctggaag ctgaagatgc tgcaacgtat      240

tactgtcatc agagtagtag tttaccgctc actttcggcg gagggaccaa ggtggagatc      300

aaacgaactg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      360

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      420

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggag                      465


<210>  113
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  113

Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu Lys Val Thr Ile Thr 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser 
        35                  40                  45              


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    50                  55                  60                  


Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys His Gln Ser Ser Ser Leu Pro Leu Thr Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            100                 105                 110         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        115                 120                 125             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
    130                 135                 140                 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155 


<210>  114
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  114

Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ile Leu Ser Leu Thr Cys 
1               5                   10                  15      


Thr Val Ser Gly Gly Ser Ile Ser Ser Gly Gly His Tyr Trp Ser Trp 
            20                  25                  30          


Ile Arg Gln His Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Tyr 
        35                  40                  45              


Tyr Ile Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
    50                  55                  60                  


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
65                  70                  75                  80  


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly 
                85                  90                  95      


Asp Tyr Tyr Gly Ile Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170         


<210>  115
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  115

Ser Pro Asp Phe Gln Ser Val Thr Pro Lys Glu Lys Val Thr Ile Thr 
1               5                   10                  15      


Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His Trp Tyr Gln Gln 
            20                  25                  30          


Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile Lys Tyr Ala Ser Gln Ser 
        35                  40                  45              


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    50                  55                  60                  


Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr 
65                  70                  75                  80  


Tyr Cys His Gln Ser Ser Ser Leu Pro Leu Thr Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
            100                 105                 110         


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
        115                 120                 125             


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
    130                 135                 140                 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155 


<210>  116
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  116

Ser Ser Gly Gly His Tyr Trp Ser 
1               5               


<210>  117
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  117

Gly Tyr Ile Tyr Tyr Ile Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys 
1               5                   10                  15      


Ser 
    


<210>  118
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  118

Asp Ser Gly Asp Tyr Tyr Gly Ile Asp Val 
1               5                   10  


<210>  119
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  119

Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser Leu His 
1               5                   10          


<210>  120
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  120

Tyr Ala Ser Gln Ser Phe Ser 
1               5           


<210>  121
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  121

His Gln Ser Ser Ser Leu Pro Leu Thr 
1               5                   


<210>  122
<211>  451
<212>  DNA
<213>  Homo sapiens

<400>  122
ggcgtggtcc agcctgggag gtccctgaga ctctcctgtg cagcgtctgg attcaccttc       60

agtagctatg gcatgcactg ggtccgccag gctccaggca aggggctgga gtgggtggca      120

gttatatggt atgatggaag tcataaatac tatgcagact ccgtgaaggg ccgattcacc      180

atctccagag acaattccaa gaacacgctg tatctgcaaa tgaacagcct gagagccgag      240

gacacggctg tgtattactg tgcgagaggc gctgtagtag taccagctgc tatggacgtc      300

tggggccaag ggaccacggt caccgtctcc tcagcctcca ccaagggccc atcggtcttc      360

cccctggcgc cctgctccag gagcacctcc gagagcacag cggccctggg ctgcctggtc      420

aaggactact tccccgaacc ggtgacggtg t                                     451


<210>  123
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  123

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser His 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Val Val Val Pro Ala 
                85                  90                  95      


Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
        115                 120                 125             


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser 
145                 150     


<210>  124
<211>  402
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  n is a, c, g, or t

<400>  124
acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg       60

gcaagtcaga acattagcag gtatttaaat tggtatcaac agaaaccagg gaaagcccct      120

aagttcctga tctatgttgc atctattttg caaagtgggg tcccatcagg gttcagtgcc      180

agtggatctg ggccagattt cactctnacc atcagcagtc tgcaacctga agattttgca      240

acttactact gtcaacagag ttacagtacc ccattcactt tcggccctgg gaccaaagtg      300

gatatcaaac gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag      360

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata ac                         402


<210>  125
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  125

Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Arg Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Val Ala Ser 
        35                  40                  45              


Ile Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Ala Ser Gly Ser Gly 
    50                  55                  60                  


Pro Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn 
    130                 


<210>  126
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  126

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser His 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Val Val Val Pro Ala 
                85                  90                  95      


Ala Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
        115                 120                 125             


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val 
145                 150 


<210>  127
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  127

Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Arg Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile Tyr Val Ala Ser 
        35                  40                  45              


Ile Leu Gln Ser Gly Val Pro Ser Gly Phe Ser Ala Ser Gly Ser Gly 
    50                  55                  60                  


Pro Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Phe Thr Phe Gly Pro 
                85                  90                  95      


Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn 
    130                 


<210>  128
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  128

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  129
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  129

Val Ile Trp Tyr Asp Gly Ser His Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  130
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  130

Gly Ala Val Val Val Pro Ala Ala Met Asp Val 
1               5                   10      


<210>  131
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  131

Arg Ala Ser Gln Asn Ile Ser Arg Tyr Leu Asn 
1               5                   10      


<210>  132
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  132

Val Ala Ser Ile Leu Gln Ser 
1               5           


<210>  133
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  133

Gln Gln Ser Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  134
<211>  438
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  n is a, c, g, or t

<400>  134
gtggtccagc ctgggaggtc cctgagactc tcctgtgcag cgtctggatt caccttcagt       60

agcngtggca tgcactgggt ccgccaggct ccaggcaagg ggctggagtg ggtggcagtt      120

atatggtctg atggaagtca taaatactat gcagactccg tgaagggccg attcaccatc      180

tccagagaca attccaagaa cacgctgtat ctgcaaatga acagcctgag agccgaggac      240

acggctgtgt attactgtgc gagaggaact atgatagtag tgggtaccct tgactactgg      300

ggccagggaa ccctggtcac cgtctcctca gcctccacca agggcccatc ggtcttcccc      360

ctggcgccct gctccaggag cacctccgag agcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccg                                                    438


<210>  135
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  135

Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys 
            20                  25                  30          


Gly Leu Glu Trp Val Ala Val Ile Trp Ser Asp Gly Ser His Lys Tyr 
        35                  40                  45              


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    50                  55                  60                  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Ala Arg Gly Thr Met Ile Val Val Gly Thr Leu 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro 
145 


<210>  136
<211>  451
<212>  DNA
<213>  Homo sapiens

<400>  136
acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg       60

gcaagtcaga gcatttgcaa ctatttaaat tggtatcagc agaaaccagg aaaagcccct      120

agggtcctga tctatgctgc atccagtttg caaggtgggg tcccgtcaag gttcagtggc      180

agtggatctg ggacagattg cactctcacc atcagcagtc tgcaacctga agattttgca      240

acttactact gtcaacagag ttacactacc ccattcactt tcggccctgg gaccagagtg      300

gatatcgaac gaactgtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag      360

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc      420

aaagtacagt ggaaggtgga taacgcctat t                                     451


<210>  137
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  137

Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Ser Ile Cys Asn Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Arg Val Leu Ile Tyr Ala Ala Ser 
        35                  40                  45              


Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Ile Asp Cys Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Thr Pro Phe Thr Phe Gly Pro 
                85                  90                  95      


Gly Thr Arg Val Asp Ile Glu Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Tyr 
145                 150 


<210>  138
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  138

Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Ser Cys Gly Met His Trp Val Arg Gln Ala Pro Gly 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Ala Val Ile Trp Ser Asp Gly Ser His Lys 
        35                  40                  45              


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    50                  55                  60                  


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
65                  70                  75                  80  


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Thr Met Ile Val Val Gly Thr 
                85                  90                  95      


Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro 
145     


<210>  139
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  139

Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
1               5                   10                  15      


Ile Thr Cys Arg Ala Ser Gln Ser Ile Cys Asn Tyr Leu Asn Trp Tyr 
            20                  25                  30          


Gln Gln Lys Pro Gly Lys Ala Pro Arg Val Leu Ile Tyr Ala Ala Ser 
        35                  40                  45              


Ser Leu Gln Gly Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Ile Asp Cys Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ile Thr Pro Phe Thr Phe Gly Pro 
                85                  90                  95      


Gly Thr Arg Val Asp Ile Glu Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Tyr 
145                 150 


<210>  140
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  140

Gly Phe Thr Phe Ser Ser Cys Gly Met His 
1               5                   10  


<210>  141
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  141

Val Ile Trp Ser Asp Gly Ser His Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  142
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  142

Gly Thr Met Ile Val Val Gly Thr Leu Asp Tyr 
1               5                   10      


<210>  143
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  143

Arg Ala Ser Gln Ser Ile Cys Asn Tyr Leu Asn 
1               5                   10      


<210>  144
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  144

Ala Ala Ser Ser Leu Gln Gly 
1               5           


<210>  145
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  145

Gln Gln Ser Tyr Ile Thr Pro Phe Thr 
1               5                   


<210>  146
<211>  562
<212>  DNA
<213>  Homo sapiens

<400>  146
tcctgtgcag cgtctggatt caccttcagt tactatggcg tctgggggag gcgtggtcca       60

gcctgggagg tccctgagac tctcctgtgc agcgtctgga ttcaccttca gtagctatgg      120

cgtgcactgg gtccgccagg ctccaggcaa ggggctggag tgggtggcag ttatatggta      180

tgatggaagt aataaatact atgcagactc cgtgaagggc cgattcacca tctccagaga      240

caattccaag agcacgctgt atctgcaaat gaacagcctg agagccgagg acacggctgt      300

gtattattgt gcgagagact cgtattacga tttttggagt ggtcggggcg gtatggacgt      360

ctggggccaa gggaccacgg tcaccgtctc ctcagcctcc accaagggcc catcggtctt      420

ccccctggcg ccctgctcca ggagcacctc cgagagcaca gcggccctgg gctgcctggt      480

caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgctc tgaccagcgg      540

cgtgcacacc ttcccagctg tc                                               562


<210>  147
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly Val His Trp Val Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp 
        35                  40                  45              


Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Tyr Tyr 
                85                  90                  95      


Asp Phe Trp Ser Gly Arg Gly Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 


<210>  148
<211>  419
<212>  DNA
<213>  Homo sapiens

<400>  148
ccactctccc tgcccgtcac ccttggacag ccggcctcca tctcctgcag gtctagtcaa       60

agcctcgtat acagtgatgg aaacacctac ttgaattggt ttcagcagag gccaggccaa      120

tctccaaggc gcctaattta taaggtttct aactgggact ctggggtccc agacagattc      180

agcggcagtg ggtcaggcac tgatttcaca ctgaaaatca gcagggtgga ggctgaggat      240

gttggggttt attactgcat gcaaggttca cactggcctc cgacgttcgg ccaagggacc      300

aaggtggaaa tcaaacgaac tgtggctgca ccatctgtct tcatcttccc gccatctgat      360

gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccac       419


<210>  149
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  149

Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys 
1               5                   10                  15      


Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
            20                  25                  30          


Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys 
        35                  40                  45              


Val Ser Asn Trp Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
65                  70                  75                  80  


Val Gly Val Tyr Tyr Cys Met Gln Gly Ser His Trp Pro Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 


<210>  150
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  150

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Val His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Ser Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Tyr Tyr Asp Phe Trp 
                85                  90                  95      


Ser Gly Arg Gly Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170     


<210>  151
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  151

Pro Leu Ser Leu Pro Val Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys 
1               5                   10                  15      


Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
            20                  25                  30          


Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr Lys 
        35                  40                  45              


Val Ser Asn Trp Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
65                  70                  75                  80  


Val Gly Val Tyr Tyr Cys Met Gln Gly Ser His Trp Pro Pro Thr Phe 
                85                  90                  95      


Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
        115                 120                 125             


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 


<210>  152
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  152

Gly Phe Thr Phe Ser Ser Tyr Gly Val His 
1               5                   10  


<210>  153
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  153

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  154
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  154

Asp Ser Tyr Tyr Asp Phe Trp Ser Gly Arg Gly Gly Met Asp Val 
1               5                   10                  15  


<210>  155
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  155

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  156
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  156

Lys Val Ser Asn Trp Asp Ser 
1               5           


<210>  157
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Gln Gly Ser His Trp Pro Pro Thr 
1               5                   


<210>  158
<211>  490
<212>  DNA
<213>  Homo sapiens

<400>  158
gtccagcctg ggaggtccct gagactctcc tgtgcagcgt ctggattcac cttcagtaac       60

tatgccatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt ggtagttatt      120

tggcatgatg gaaataataa atactatgca gagtccgtga agggccgatt caccatctcc      180

agagacaatt ccaagaacac gctgtatctg caaatgaaca gcctgagagc cgaggacacg      240

gctgtatatt actgtgcgag agatcagggc actggctggt acggaggctt tgacttctgg      300

ggccagggaa ccctggtcac cgtctcctca gcctccacca agggcccatc ggtcttcccc      360

ctggcgccct gctccaggag cacctccgag agcacagcgg ccctgggctg cctggtcaag      420

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgctctgac cagcggcgtg      480

cacaccttcc                                                             490


<210>  159
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  159

Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Thr Phe Ser Asn Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
            20                  25                  30          


Gly Leu Glu Trp Val Val Val Ile Trp His Asp Gly Asn Asn Lys Tyr 
        35                  40                  45              


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    50                  55                  60                  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Ala Arg Asp Gln Gly Thr Gly Trp Tyr Gly Gly 
                85                  90                  95      


Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe 
            


<210>  160
<211>  419
<212>  DNA
<213>  Homo sapiens

<400>  160
cctggagagc cggcttccat ctcttgcagg tctagtcaga gcctcctgca tagtaatgga       60

tacaactatt tggattggta cctgcagaag ccaggacagt ctccacagct cctgatctat      120

ttgggttcta atcgggcctc cggggtccct gacaggttca gtggcagtgg atcaggcaca      180

gattttacac tgaaactcag cagagtggag gctgaggatg ttggggttta ttactgcatg      240

caagctctac aaactcctct cactttcggc ggagggacca aggtggagat caaacgaact      300

gtggctgcac catctgtctt catcttcccg ccatctgatg agcagttgaa atctggaact      360

gcctctgttg tgtgcctgct gaataacttc tatcccagar aggccaaagt acattccat       419


<210>  161
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  161

Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
1               5                   10                  15      


His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
            20                  25                  30          


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
        35                  40                  45              


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    50                  55                  60                  


Lys Leu Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
65                  70                  75                  80  


Gln Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
                85                  90                  95      


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            100                 105                 110         


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        115                 120                 125             


Asn Phe Tyr Pro Arg 
    130             


<210>  162
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  162

Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
1               5                   10                  15      


Thr Phe Ser Asn Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys 
            20                  25                  30          


Gly Leu Glu Trp Val Val Val Ile Trp His Asp Gly Asn Asn Lys Tyr 
        35                  40                  45              


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    50                  55                  60                  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
65                  70                  75                  80  


Ala Val Tyr Tyr Cys Ala Arg Asp Gln Gly Thr Gly Trp Tyr Gly Gly 
                85                  90                  95      


Phe Asp Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
            100                 105                 110         


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr 
        115                 120                 125             


Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
145                 150                 155                 160 


His Thr Phe 
            


<210>  163
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  163

Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu 
1               5                   10                  15      


His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly 
            20                  25                  30          


Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly 
        35                  40                  45              


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    50                  55                  60                  


Lys Leu Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met 
65                  70                  75                  80  


Gln Ala Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu 
                85                  90                  95      


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            100                 105                 110         


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        115                 120                 125             


Asn Phe Tyr Pro Arg 
    130             


<210>  164
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  164

Gly Phe Thr Phe Ser Asn Tyr Ala Met His 
1               5                   10  


<210>  165
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  165

Val Ile Trp His Asp Gly Asn Asn Lys Tyr Tyr Ala Glu Ser Val 
1               5                   10                  15  


<210>  166
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  166

Asp Gln Gly Thr Gly Trp Tyr Gly Gly Phe Asp Phe 
1               5                   10          


<210>  167
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  167

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  168
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  168

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  169
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  170
<211>  1612
<212>  DNA
<213>  Mus musculus

<400>  170
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggaaac ggacactctc ctgctgtggg      120

tactgttgct ttgggtgcca ggatctacgg gcgaggcgaa gctccaggaa agcgggccgg      180

tactggtcaa acccggcgct agcgtgaaaa tgagttgcaa ggccagcggt tatactttca      240

ccgactatta catgaattgg gtaaagcaga gccacgggaa gtcattggaa tggattggag      300

taatcaaccc ctacaacggg gacaccagtt ataaccaaaa gttcaaggga aaggcgacac      360

tcactgtgga taaaagttca agcacagcct acatggaact taattccttg acatctgagg      420

acagcgcagt atactattgt gctagatatt acggtagttg gttcgcctac tgggggcaag      480

gaacgctaat cactgtatca accgcaaaaa ctacagcacc ctctgtatac cctctcgcac      540

ctgtgtgcgg agacacaact ggcagctcag taaccctcgg gtgcctggtt aaggggtatt      600

tcccagagcc agtgactctc acctggaatt ctggaagcct tagttcagga gtacatactt      660

tccccgctgt gctacaatca gatctgtaca ccctgagttc aagcgttacc gttacgagta      720

gtacttggcc ttctcagtcc ataacctgta acgtcgccca tcccgcctct tctaccaagg      780

ttgacaagaa gattgaaccg agaggaccca ccattaaacc ctgccctcct tgcaagtgtc      840

ctgctccaaa cctcttggga ggcccgtccg tcttcatctt tcccccaaag atcaaagacg      900

tgctcatgat ttcgctgtca ccaatcgtaa cgtgcgttgt ggtggacgtc tccgaggacg      960

acccagatgt ccagatatcc tggttcgtaa acaatgtgga ggtccataca gcccagacgc     1020

agacccaccg cgaggactat aattctaccc tcagggttgt ctctgccctg ccaattcagc     1080

atcaggactg gatgagcggg aaagagttca agtgtaaagt gaataataaa gatctgcctg     1140

cccccatcga gagaactatc agtaaaccta aaggatccgt gcgcgctccc caggtctacg     1200

tcctgccccc cccagaagag gaaatgacta agaagcaggt cacacttacc tgcatggtga     1260

cggattttat gccagaagac atttatgtgg aatggacaaa taatggaaag acagagctca     1320

attataagaa cacagagcca gtgttagatt cagatggcag ttattttatg tacagcaaac     1380

tgcgcgtaga aaaaaaaaat tgggtcgagc gcaatagcta ctcctgcagc gtcgtgcatg     1440

aagggctaca caatcaccac accacgaaga gcttttcccg gacacctggg aaatgataat     1500

aggctggagc ctcggtggcc atgcttcttg ccccttgggc ctccccccag cccctcctcc     1560

ccttcctgca cccgtacccc cgtggtcttt gaataaagtc tgagtgggcg gc             1612


<210>  171
<211>  467
<212>  PRT
<213>  Mus musculus

<400>  171

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ala Lys Leu Gln Glu Ser Gly Pro Val Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Val Ile Asn Pro Tyr Asn Gly Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Trp Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Ile Thr Val Ser Thr Ala Lys Thr Thr Ala Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr 
225                 230                 235                 240 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            260                 265                 270         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        275                 280                 285             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    290                 295                 300                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
305                 310                 315                 320 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                325                 330                 335     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        355                 360                 365             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    370                 375                 380                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
385                 390                 395                 400 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            420                 425                 430         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        435                 440                 445             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  172
<211>  1401
<212>  DNA
<213>  Mus musculus

<400>  172
atggaaacgg acactctcct gctgtgggta ctgttgcttt gggtgccagg atctacgggc       60

gaggcgaagc tccaggaaag cgggccggta ctggtcaaac ccggcgctag cgtgaaaatg      120

agttgcaagg ccagcggtta tactttcacc gactattaca tgaattgggt aaagcagagc      180

cacgggaagt cattggaatg gattggagta atcaacccct acaacgggga caccagttat      240

aaccaaaagt tcaagggaaa ggcgacactc actgtggata aaagttcaag cacagcctac      300

atggaactta attccttgac atctgaggac agcgcagtat actattgtgc tagatattac      360

ggtagttggt tcgcctactg ggggcaagga acgctaatca ctgtatcaac cgcaaaaact      420

acagcaccct ctgtataccc tctcgcacct gtgtgcggag acacaactgg cagctcagta      480

accctcgggt gcctggttaa ggggtatttc ccagagccag tgactctcac ctggaattct      540

ggaagcctta gttcaggagt acatactttc cccgctgtgc tacaatcaga tctgtacacc      600

ctgagttcaa gcgttaccgt tacgagtagt acttggcctt ctcagtccat aacctgtaac      660

gtcgcccatc ccgcctcttc taccaaggtt gacaagaaga ttgaaccgag aggacccacc      720

attaaaccct gccctccttg caagtgtcct gctccaaacc tcttgggagg cccgtccgtc      780

ttcatctttc ccccaaagat caaagacgtg ctcatgattt cgctgtcacc aatcgtaacg      840

tgcgttgtgg tggacgtctc cgaggacgac ccagatgtcc agatatcctg gttcgtaaac      900

aatgtggagg tccatacagc ccagacgcag acccaccgcg aggactataa ttctaccctc      960

agggttgtct ctgccctgcc aattcagcat caggactgga tgagcgggaa agagttcaag     1020

tgtaaagtga ataataaaga tctgcctgcc cccatcgaga gaactatcag taaacctaaa     1080

ggatccgtgc gcgctcccca ggtctacgtc ctgccccccc cagaagagga aatgactaag     1140

aagcaggtca cacttacctg catggtgacg gattttatgc cagaagacat ttatgtggaa     1200

tggacaaata atggaaagac agagctcaat tataagaaca cagagccagt gttagattca     1260

gatggcagtt attttatgta cagcaaactg cgcgtagaaa aaaaaaattg ggtcgagcgc     1320

aatagctact cctgcagcgt cgtgcatgaa gggctacaca atcaccacac cacgaagagc     1380

ttttcccgga cacctgggaa a                                               1401


<210>  173
<211>  1671
<212>  DNA
<213>  Mus musculus

<400>  173
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg aaacggacac       60

tctcctgctg tgggtactgt tgctttgggt gccaggatct acgggcgagg cgaagctcca      120

ggaaagcggg ccggtactgg tcaaacccgg cgctagcgtg aaaatgagtt gcaaggccag      180

cggttatact ttcaccgact attacatgaa ttgggtaaag cagagccacg ggaagtcatt      240

ggaatggatt ggagtaatca acccctacaa cggggacacc agttataacc aaaagttcaa      300

gggaaaggcg acactcactg tggataaaag ttcaagcaca gcctacatgg aacttaattc      360

cttgacatct gaggacagcg cagtatacta ttgtgctaga tattacggta gttggttcgc      420

ctactggggg caaggaacgc taatcactgt atcaaccgca aaaactacag caccctctgt      480

ataccctctc gcacctgtgt gcggagacac aactggcagc tcagtaaccc tcgggtgcct      540

ggttaagggg tatttcccag agccagtgac tctcacctgg aattctggaa gccttagttc      600

aggagtacat actttccccg ctgtgctaca atcagatctg tacaccctga gttcaagcgt      660

taccgttacg agtagtactt ggccttctca gtccataacc tgtaacgtcg cccatcccgc      720

ctcttctacc aaggttgaca agaagattga accgagagga cccaccatta aaccctgccc      780

tccttgcaag tgtcctgctc caaacctctt gggaggcccg tccgtcttca tctttccccc      840

aaagatcaaa gacgtgctca tgatttcgct gtcaccaatc gtaacgtgcg ttgtggtgga      900

cgtctccgag gacgacccag atgtccagat atcctggttc gtaaacaatg tggaggtcca      960

tacagcccag acgcagaccc accgcgagga ctataattct accctcaggg ttgtctctgc     1020

cctgccaatt cagcatcagg actggatgag cgggaaagag ttcaagtgta aagtgaataa     1080

taaagatctg cctgccccca tcgagagaac tatcagtaaa cctaaaggat ccgtgcgcgc     1140

tccccaggtc tacgtcctgc cccccccaga agaggaaatg actaagaagc aggtcacact     1200

tacctgcatg gtgacggatt ttatgccaga agacatttat gtggaatgga caaataatgg     1260

aaagacagag ctcaattata agaacacaga gccagtgtta gattcagatg gcagttattt     1320

tatgtacagc aaactgcgcg tagaaaaaaa aaattgggtc gagcgcaata gctactcctg     1380

cagcgtcgtg catgaagggc tacacaatca ccacaccacg aagagctttt cccggacacc     1440

tgggaaatga taataggctg gagcctcggt ggccatgctt cttgcccctt gggcctcccc     1500

ccagcccctc ctccccttcc tgcacccgta cccccgtggt ctttgaataa agtctgagtg     1560

ggcggcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaatcta g              1671


<210>  174
<211>  1630
<212>  DNA
<213>  Mus musculus

<400>  174
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggaaac ggacactctc ctgctgtggg      120

tactgttgct ttgggtgcca ggatctacgg gcgaggcgaa gctccaggaa agcgggccgg      180

tactggtcaa acccggcgct agcgtgaaaa tgagttgcaa ggccagcggt tatactttca      240

ccgactatta catgaattgg gtaaagcaga gccacgggaa gtcattggaa tggattggag      300

taatcaaccc ctacaacggg gacaccagtt ataaccaaaa gttcaaggga aaggcgacac      360

tcactgtgga taaaagttca agcacagcct acatggaact taattccttg acatctgagg      420

acagcgcagt atactattgt gctagatatt acggtagttg gttcgcctac tgggggcaag      480

gaacgctaat cactgtatca accgccaaaa ccacaccgcc ttccgtgtac cctctagcgc      540

ccggttgtgg tgacactaca ggatcgtctg tgactttggg ctgccttgtg aaaggatatt      600

tccctgaatc tgttactgtg acctggaact ctggctcgct gagtagttca gtgcacacat      660

tccccgccct gcttcagagc ggtttgtaca ccatgtcttc ttcagttacc gtcccctcat      720

caacgtggcc ttcacagact gtcacgtgtt ctgttgccca cccagcaagc tccaccaccg      780

tggataaaaa actggagcca agcgggccga tctcaaccat caatccgtgt cctccatgca      840

aggagtgcca caagtgtcct gccccaaatc tggagggagg cccgtccgtc tttatttttc      900

cacccaatat taaagacgtc ctgatgataa gcttgacccc aaaagtaact tgcgttgtgg      960

tggatgtctc ggaggatgac cccgatgttc agatcagctg gttcgtgaac aacgtcgagg     1020

tacatactgc gcagacccaa actcaccgag aagattataa cagtactatt cgagtggtgt     1080

ctacccttcc catccagcac caggactgga tgtccggaaa ggaatttaaa tgcaaggtga     1140

ataataaaga tctaccctca ccaattgaac gaacgataag taagatcaaa ggactggtga     1200

gggccccaca ggtgtatatt ctcccacctc ctgccgagca gctgtcccgc aaagacgtct     1260

ccttaacatg tttagtcgtg ggattcaacc ctggagatat tagcgtcgag tggaccagta     1320

acggtcacac ggaagagaac tacaaagaca cggcgcccgt gctcgacagt gacggcagtt     1380

acttcatcta ctccaaactt aatatgaaga ccagtaaatg ggagaagaca gactcctttt     1440

cttgcaatgt gcgccacgag ggcctgaaga actactacct gaaaaagaca atcagcagaa     1500

gccctggcaa gtgataatag gctggagcct cggtggccat gcttcttgcc ccttgggcct     1560

ccccccagcc cctcctcccc ttcctgcacc cgtacccccg tggtctttga ataaagtctg     1620

agtgggcggc                                                            1630


<210>  175
<211>  473
<212>  PRT
<213>  Mus musculus

<400>  175

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Ala Lys Leu Gln Glu Ser Gly Pro Val Leu Val 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              


Phe Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Val Ile Asn Pro Tyr Asn Gly Asp Thr Ser Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Trp Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Ile Thr Val Ser Thr Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp Thr Thr Gly Ser Ser Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Ser Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser Val His Thr Phe Pro Ala 
            180                 185                 190         


Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Gln Thr Val Thr Cys Ser Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Thr Val Asp Lys Lys Leu Glu Pro Ser Gly Pro Ile 
225                 230                 235                 240 


Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys Glu Cys His Lys Cys Pro 
                245                 250                 255     


Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Asn 
            260                 265                 270         


Ile Lys Asp Val Leu Met Ile Ser Leu Thr Pro Lys Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    290                 295                 300                 


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
305                 310                 315                 320 


Asp Tyr Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Gln His 
                325                 330                 335     


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            340                 345                 350         


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ile Lys Gly Leu 
        355                 360                 365             


Val Arg Ala Pro Gln Val Tyr Ile Leu Pro Pro Pro Ala Glu Gln Leu 
    370                 375                 380                 


Ser Arg Lys Asp Val Ser Leu Thr Cys Leu Val Val Gly Phe Asn Pro 
385                 390                 395                 400 


Gly Asp Ile Ser Val Glu Trp Thr Ser Asn Gly His Thr Glu Glu Asn 
                405                 410                 415     


Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Ile 
            420                 425                 430         


Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys Trp Glu Lys Thr Asp Ser 
        435                 440                 445             


Phe Ser Cys Asn Val Arg His Glu Gly Leu Lys Asn Tyr Tyr Leu Lys 
    450                 455                 460                 


Lys Thr Ile Ser Arg Ser Pro Gly Lys 
465                 470             


<210>  176
<211>  1419
<212>  DNA
<213>  Mus musculus

<400>  176
atggaaacgg acactctcct gctgtgggta ctgttgcttt gggtgccagg atctacgggc       60

gaggcgaagc tccaggaaag cgggccggta ctggtcaaac ccggcgctag cgtgaaaatg      120

agttgcaagg ccagcggtta tactttcacc gactattaca tgaattgggt aaagcagagc      180

cacgggaagt cattggaatg gattggagta atcaacccct acaacgggga caccagttat      240

aaccaaaagt tcaagggaaa ggcgacactc actgtggata aaagttcaag cacagcctac      300

atggaactta attccttgac atctgaggac agcgcagtat actattgtgc tagatattac      360

ggtagttggt tcgcctactg ggggcaagga acgctaatca ctgtatcaac cgccaaaacc      420

acaccgcctt ccgtgtaccc tctagcgccc ggttgtggtg acactacagg atcgtctgtg      480

actttgggct gccttgtgaa aggatatttc cctgaatctg ttactgtgac ctggaactct      540

ggctcgctga gtagttcagt gcacacattc cccgccctgc ttcagagcgg tttgtacacc      600

atgtcttctt cagttaccgt cccctcatca acgtggcctt cacagactgt cacgtgttct      660

gttgcccacc cagcaagctc caccaccgtg gataaaaaac tggagccaag cgggccgatc      720

tcaaccatca atccgtgtcc tccatgcaag gagtgccaca agtgtcctgc cccaaatctg      780

gagggaggcc cgtccgtctt tatttttcca cccaatatta aagacgtcct gatgataagc      840

ttgaccccaa aagtaacttg cgttgtggtg gatgtctcgg aggatgaccc cgatgttcag      900

atcagctggt tcgtgaacaa cgtcgaggta catactgcgc agacccaaac tcaccgagaa      960

gattataaca gtactattcg agtggtgtct acccttccca tccagcacca ggactggatg     1020

tccggaaagg aatttaaatg caaggtgaat aataaagatc taccctcacc aattgaacga     1080

acgataagta agatcaaagg actggtgagg gccccacagg tgtatattct cccacctcct     1140

gccgagcagc tgtcccgcaa agacgtctcc ttaacatgtt tagtcgtggg attcaaccct     1200

ggagatatta gcgtcgagtg gaccagtaac ggtcacacgg aagagaacta caaagacacg     1260

gcgcccgtgc tcgacagtga cggcagttac ttcatctact ccaaacttaa tatgaagacc     1320

agtaaatggg agaagacaga ctccttttct tgcaatgtgc gccacgaggg cctgaagaac     1380

tactacctga aaaagacaat cagcagaagc cctggcaag                            1419


<210>  177
<211>  1689
<212>  DNA
<213>  Mus musculus

<400>  177
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg aaacggacac       60

tctcctgctg tgggtactgt tgctttgggt gccaggatct acgggcgagg cgaagctcca      120

ggaaagcggg ccggtactgg tcaaacccgg cgctagcgtg aaaatgagtt gcaaggccag      180

cggttatact ttcaccgact attacatgaa ttgggtaaag cagagccacg ggaagtcatt      240

ggaatggatt ggagtaatca acccctacaa cggggacacc agttataacc aaaagttcaa      300

gggaaaggcg acactcactg tggataaaag ttcaagcaca gcctacatgg aacttaattc      360

cttgacatct gaggacagcg cagtatacta ttgtgctaga tattacggta gttggttcgc      420

ctactggggg caaggaacgc taatcactgt atcaaccgcc aaaaccacac cgccttccgt      480

gtaccctcta gcgcccggtt gtggtgacac tacaggatcg tctgtgactt tgggctgcct      540

tgtgaaagga tatttccctg aatctgttac tgtgacctgg aactctggct cgctgagtag      600

ttcagtgcac acattccccg ccctgcttca gagcggtttg tacaccatgt cttcttcagt      660

taccgtcccc tcatcaacgt ggccttcaca gactgtcacg tgttctgttg cccacccagc      720

aagctccacc accgtggata aaaaactgga gccaagcggg ccgatctcaa ccatcaatcc      780

gtgtcctcca tgcaaggagt gccacaagtg tcctgcccca aatctggagg gaggcccgtc      840

cgtctttatt tttccaccca atattaaaga cgtcctgatg ataagcttga ccccaaaagt      900

aacttgcgtt gtggtggatg tctcggagga tgaccccgat gttcagatca gctggttcgt      960

gaacaacgtc gaggtacata ctgcgcagac ccaaactcac cgagaagatt ataacagtac     1020

tattcgagtg gtgtctaccc ttcccatcca gcaccaggac tggatgtccg gaaaggaatt     1080

taaatgcaag gtgaataata aagatctacc ctcaccaatt gaacgaacga taagtaagat     1140

caaaggactg gtgagggccc cacaggtgta tattctccca cctcctgccg agcagctgtc     1200

ccgcaaagac gtctccttaa catgtttagt cgtgggattc aaccctggag atattagcgt     1260

cgagtggacc agtaacggtc acacggaaga gaactacaaa gacacggcgc ccgtgctcga     1320

cagtgacggc agttacttca tctactccaa acttaatatg aagaccagta aatgggagaa     1380

gacagactcc ttttcttgca atgtgcgcca cgagggcctg aagaactact acctgaaaaa     1440

gacaatcagc agaagccctg gcaagtgata ataggctgga gcctcggtgg ccatgcttct     1500

tgccccttgg gcctcccccc agcccctcct ccccttcctg cacccgtacc cccgtggtct     1560

ttgaataaag tctgagtggg cggcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaatctag                                                             1689


<210>  178
<211>  928
<212>  DNA
<213>  Mus musculus

<400>  178
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggaaac ggacactctc ctgctgtggg      120

tactgttgct ttgggtgcca ggatctacgg gcgatattgt gatgactcaa accacactga      180

gcctcccggt gagcctgggg gatcaagcct ccattagttg ccgaagctcc caaagtatcg      240

tgcactccaa cggcaacacc tatctggagt ggtatttaca gaagcccgga cagagcccaa      300

agctgctcat ctacaaagtg tccaatcgct tctcgggcgt gccagacaga ttctcaggta      360

gtgggtctgg gacagatttt accctgaaga tatctcgagt ggaggcggag gatttaggag      420

tctactattg tttccagggt agtcatgtgc cttacacttt cggtgggggg acaaaattag      480

aaatcaaaag ggccgacgca gccccaacgg tctctatttt ccctccatct tccgagcagc      540

tgacgagtgg cggggcctca gtggtctgct tcctgaataa tttctacccc aaggacataa      600

acgtgaaatg gaaaattgat ggatcagaaa ggcagaatgg cgttctgaac tcctggaccg      660

accaggatag caaggactcc acctactcga tgtccagtac actcactctg actaaggacg      720

aatatgaaag acataattca tacacctgtg aggctacaca taaaacatcc acttccccaa      780

tcgtcaaatc cttcaatcga aatgagtgct gataataggc tggagcctcg gtggccatgc      840

ttcttgcccc ttgggcctcc ccccagcccc tcctcccctt cctgcacccg tacccccgtg      900

gtctttgaat aaagtctgag tgggcggc                                         928


<210>  179
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  179

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Met Thr Gln Thr Thr Leu Ser Leu Pro 
            20                  25                  30          


Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  180
<211>  717
<212>  DNA
<213>  Mus musculus

<400>  180
atggaaacgg acactctcct gctgtgggta ctgttgcttt gggtgccagg atctacgggc       60

gatattgtga tgactcaaac cacactgagc ctcccggtga gcctggggga tcaagcctcc      120

attagttgcc gaagctccca aagtatcgtg cactccaacg gcaacaccta tctggagtgg      180

tatttacaga agcccggaca gagcccaaag ctgctcatct acaaagtgtc caatcgcttc      240

tcgggcgtgc cagacagatt ctcaggtagt gggtctggga cagattttac cctgaagata      300

tctcgagtgg aggcggagga tttaggagtc tactattgtt tccagggtag tcatgtgcct      360

tacactttcg gtggggggac aaaattagaa atcaaaaggg ccgacgcagc cccaacggtc      420

tctattttcc ctccatcttc cgagcagctg acgagtggcg gggcctcagt ggtctgcttc      480

ctgaataatt tctaccccaa ggacataaac gtgaaatgga aaattgatgg atcagaaagg      540

cagaatggcg ttctgaactc ctggaccgac caggatagca aggactccac ctactcgatg      600

tccagtacac tcactctgac taaggacgaa tatgaaagac ataattcata cacctgtgag      660

gctacacata aaacatccac ttccccaatc gtcaaatcct tcaatcgaaa tgagtgc         717


<210>  181
<211>  987
<212>  DNA
<213>  Mus musculus

<400>  181
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg aaacggacac       60

tctcctgctg tgggtactgt tgctttgggt gccaggatct acgggcgata ttgtgatgac      120

tcaaaccaca ctgagcctcc cggtgagcct gggggatcaa gcctccatta gttgccgaag      180

ctcccaaagt atcgtgcact ccaacggcaa cacctatctg gagtggtatt tacagaagcc      240

cggacagagc ccaaagctgc tcatctacaa agtgtccaat cgcttctcgg gcgtgccaga      300

cagattctca ggtagtgggt ctgggacaga ttttaccctg aagatatctc gagtggaggc      360

ggaggattta ggagtctact attgtttcca gggtagtcat gtgccttaca ctttcggtgg      420

ggggacaaaa ttagaaatca aaagggccga cgcagcccca acggtctcta ttttccctcc      480

atcttccgag cagctgacga gtggcggggc ctcagtggtc tgcttcctga ataatttcta      540

ccccaaggac ataaacgtga aatggaaaat tgatggatca gaaaggcaga atggcgttct      600

gaactcctgg accgaccagg atagcaagga ctccacctac tcgatgtcca gtacactcac      660

tctgactaag gacgaatatg aaagacataa ttcatacacc tgtgaggcta cacataaaac      720

atccacttcc ccaatcgtca aatccttcaa tcgaaatgag tgctgataat aggctggagc      780

ctcggtggcc atgcttcttg ccccttgggc ctccccccag cccctcctcc ccttcctgca      840

cccgtacccc cgtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aatctag                                          987


<210>  182
<211>  355
<212>  DNA
<213>  Homo sapiens

<400>  182
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc      300

tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  183
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  183

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  184
<211>  325
<212>  DNA
<213>  Homo sapiens

<400>  184
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttggc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcattca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  185
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  185

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  186
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  186

Ser Tyr Thr Met His 
1               5   


<210>  187
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  187

Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  188
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  188

Thr Gly Trp Leu Gly Pro Phe Asp Tyr 
1               5                   


<210>  189
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  189

Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  190
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  190

Gly Ala Phe Ser Arg Ala Thr 
1               5           


<210>  191
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  191

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  192
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  192
ccuuagcaga gcuguggagu gugacaaugg uguuuguguc uaaacuauca aacgccauua       60

ucacacuaaa uagcuacugc uaggc                                             85


<210>  193
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  193
aacgccauua ucacacuaaa ua                                                22


<210>  194
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  194
uauuuagugu gauaauggcg uu                                                22


<210>  195
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  195
uggaguguga caaugguguu ug                                                22


<210>  196
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  196
caaacaccau ugucacacuc ca                                                22


<210>  197
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  197
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  198
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  198
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  199
<211>  145
<212>  RNA
<213>  Homo sapiens

<400>  199
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaac                                            145


<210>  200
<211>  42
<212>  RNA
<213>  Homo sapiens

<400>  200
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210>  201
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  201
gggagaucag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  202
<211>  145
<212>  RNA
<213>  Homo sapiens

<400>  202
ggaauaaaag ucucaacaca acauauacaa aacaaacgaa ucucaagcaa ucaagcauuc       60

uacuucuauu gcagcaauuu aaaucauuuc uuuuaaagca aaagcaauuu ucugaaaauu      120

uucaccauuu acgaacgaua gcaac                                            145


<210>  203
<211>  42
<212>  RNA
<213>  Homo sapiens

<400>  203
gggagacaag cuuggcauuc cgguacuguu gguaaagcca cc                          42


<210>  204
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  204
gggaauuaac agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  205
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  205
gggaaauuag acagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  206
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  206
gggaaauaag agaguaaaga acaguaagaa gaaauauaag agccacc                     47


<210>  207
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  207
gggaaaaaag agagaaaaga agacuaagaa gaaauauaag agccacc                     47


<210>  208
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  208
gggaaauaag agagaaaaga agaguaagaa gauauauaag agccacc                     47


<210>  209
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  209
gggaaauaag agacaaaaca agaguaagaa gaaauauaag agccacc                     47


<210>  210
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  210
gggaaauuag agaguaaaga acaguaagua gaauuaaaag agccacc                     47


<210>  211
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  211
gggaaauaag agagaauaga agaguaagaa gaaauauaag agccacc                     47


<210>  212
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  212
gggaaauaag agagaaaaga agaguaagaa gaaaauuaag agccacc                     47


<210>  213
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  213
gggaaauaag agagaaaaga agaguaagaa gaaauuuaag agccacc                     47


<210>  214
<211>  47
<212>  RNA
<213>  Homo sapiens

<400>  214
gggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  215
<211>  371
<212>  RNA
<213>  Homo sapiens

<400>  215
gcgccugccc accugccacc gacugcugga acccagccag ugggagggcc uggcccacca       60

gaguccugcu cccucacucc ucgccccgcc cccuguccca gagucccacc ugggggcucu      120

cuccacccuu cucagaguuc caguuucaac cagaguucca accaaugggc uccauccucu      180

ggauucuggc caaugaaaua ucucccuggc aggguccucu ucuuuuccca gagcuccacc      240

ccaaccagga gcucuaguua auggagagcu cccagcacac ucggagcuug ugcuuugucu      300

ccacgcaaag cgauaaauaa aagcauuggu ggccuuuggu cuuugaauaa agccugagua      360

ggaagucuag a                                                           371


<210>  216
<211>  568
<212>  RNA
<213>  Homo sapiens

<400>  216
gccccugccg cucccacccc cacccaucug ggccccgggu ucaagagaga gcggggucug       60

aucucgugua gccauauaga guuugcuucu gagugucugc uuuguuuagu agaggugggc      120

aggaggagcu gaggggcugg ggcuggggug uugaaguugg cuuugcaugc ccagcgaugc      180

gccucccugu gggaugucau cacccuggga accgggagug gcccuuggcu cacuguguuc      240

ugcaugguuu ggaucugaau uaauuguccu uucuucuaaa ucccaaccga acuucuucca      300

accuccaaac uggcuguaac cccaaaucca agccauuaac uacaccugac aguagcaauu      360

gucugauuaa ucacuggccc cuugaagaca gcagaauguc ccuuugcaau gaggaggaga      420

ucugggcugg gcgggccagc uggggaagca uuugacuauc uggaacuugu gugugccucc      480

ucagguaugg cagugacuca ccugguuuua auaaaacaac cugcaacauc ucauggucuu      540

ugaauaaagc cugaguagga agucuaga                                         568


<210>  217
<211>  289
<212>  RNA
<213>  Homo sapiens

<400>  217
acacacucca ccuccagcac gcgacuucuc aggacgacga aucuucucaa ugggggggcg       60

gcugagcucc agccaccccg cagucacuuu cuuuguaaca acuuccguug cugccaucgu      120

aaacugacac aguguuuaua acguguacau acauuaacuu auuaccucau uuuguuauuu      180

uucgaaacaa agcccugugg aagaaaaugg aaaacuugaa gaagcauuaa agucauucug      240

uuaagcugcg uaaauggucu uugaauaaag ccugaguagg aagucuaga                  289


<210>  218
<211>  379
<212>  RNA
<213>  Homo sapiens

<400>  218
caucacauuu aaaagcaucu cagccuacca ugagaauaag agaaagaaaa ugaagaucaa       60

aagcuuauuc aucuguuuuu cuuuuucguu gguguaaagc caacacccug ucuaaaaaac      120

auaaauuucu uuaaucauuu ugccucuuuu cucugugcuu caauuaauaa aaaauggaaa      180

gaaucuaaua gagugguaca gcacuguuau uuuucaaaga uguguugcua uccugaaaau      240

ucuguagguu cuguggaagu uccaguguuc ucucuuauuc cacuucggua gaggauuucu      300

aguuucuugu gggcuaauua aauaaaucau uaauacucuu cuaauggucu uugaauaaag      360

ccugaguagg aagucuaga                                                   379


<210>  219
<211>  118
<212>  RNA
<213>  Homo sapiens

<400>  219
gcugccuucu gcggggcuug ccuucuggcc augcccuucu ucucucccuu gcaccuguac       60

cucuuggucu uugaauaaag ccugaguagg aaggcggccg cucgagcaug caucuaga        118


<210>  220
<211>  908
<212>  RNA
<213>  Homo sapiens

<400>  220
gccaagcccu ccccauccca uguauuuauc ucuauuuaau auuuaugucu auuuaagccu       60

cauauuuaaa gacagggaag agcagaacgg agccccaggc cucugugucc uucccugcau      120

uucugaguuu cauucuccug ccuguagcag ugagaaaaag cuccuguccu cccauccccu      180

ggacugggag guagauaggu aaauaccaag uauuuauuac uaugacugcu ccccagcccu      240

ggcucugcaa ugggcacugg gaugagccgc ugugagcccc ugguccugag gguccccacc      300

ugggacccuu gagaguauca ggucucccac gugggagaca agaaaucccu guuuaauauu      360

uaaacagcag uguuccccau cuggguccuu gcaccccuca cucuggccuc agccgacugc      420

acagcggccc cugcaucccc uuggcuguga ggccccugga caagcagagg uggccagagc      480

ugggaggcau ggcccugggg ucccacgaau uugcugggga aucucguuuu ucuucuuaag      540

acuuuuggga caugguuuga cucccgaaca ucaccgacgc gucuccuguu uuucugggug      600

gccucgggac accugcccug cccccacgag ggucaggacu gugacucuuu uuagggccag      660

gcaggugccu ggacauuugc cuugcuggac ggggacuggg gaugugggag ggagcagaca      720

ggaggaauca ugucaggccu gugugugaaa ggaagcucca cugucacccu ccaccucuuc      780

accccccacu caccaguguc cccuccacug ucacauugua acugaacuuc aggauaauaa      840

aguguuugcc uccauggucu uugaauaaag ccugaguagg aaggcggccg cucgagcaug      900

caucuaga                                                               908


<210>  221
<211>  835
<212>  RNA
<213>  Homo sapiens

<400>  221
acucaaucua aauuaaaaaa gaaagaaauu ugaaaaaacu uucucuuugc cauuucuucu       60

ucuucuuuuu uaacugaaag cugaauccuu ccauuucuuc ugcacaucua cuugcuuaaa      120

uugugggcaa aagagaaaaa gaaggauuga ucagagcauu gugcaauaca guuucauuaa      180

cuccuucccc cgcuccccca aaaauuugaa uuuuuuuuuc aacacucuua caccuguuau      240

ggaaaauguc aaccuuugua agaaaaccaa aauaaaaauu gaaaaauaaa aaccauaaac      300

auuugcacca cuuguggcuu uugaauaucu uccacagagg gaaguuuaaa acccaaacuu      360

ccaaagguuu aaacuaccuc aaaacacuuu cccaugagug ugauccacau uguuaggugc      420

ugaccuagac agagaugaac ugagguccuu guuuuguuuu guucauaaua caaaggugcu      480

aauuaauagu auuucagaua cuugaagaau guugauggug cuagaagaau uugagaagaa      540

auacuccugu auugaguugu aucguguggu guauuuuuua aaaaauuuga uuuagcauuc      600

auauuuucca ucuuauuccc aauuaaaagu augcagauua uuugcccaaa ucuucuucag      660

auucagcauu uguucuuugc cagucucauu uucaucuucu uccaugguuc cacagaagcu      720

uuguuucuug ggcaagcaga aaaauuaaau uguaccuauu uuguauaugu gagauguuua      780

aauaaauugu gaaaaaaaug aaauaaagca uguuugguuu uccaaaagaa cauau           835


<210>  222
<211>  297
<212>  RNA
<213>  Homo sapiens

<400>  222
cgccgccgcc cgggccccgc agucgagggu cgugagccca ccccguccau ggugcuaagc       60

gggcccgggu cccacacggc cagcaccgcu gcucacucgg acgacgcccu gggccugcac      120

cucuccagcu ccucccacgg gguccccgua gccccggccc ccgcccagcc ccaggucucc      180

ccaggcccuc cgcaggcugc ccggccuccc ucccccugca gccaucccaa ggcuccugac      240

cuaccuggcc ccugagcucu ggagcaagcc cugacccaau aaaggcuuug aacccau         297


<210>  223
<211>  602
<212>  RNA
<213>  Homo sapiens

<400>  223
ggggcuagag cccucuccgc acagcgugga gacggggcaa ggaggggggu uauuaggauu       60

ggugguuuug uuuugcuuug uuuaaagccg ugggaaaaug gcacaacuuu accucugugg      120

gagaugcaac acugagagcc aagggguggg aguugggaua auuuuuauau aaaagaaguu      180

uuuccacuuu gaauugcuaa aaguggcauu uuuccuaugu gcagucacuc cucucauuuc      240

uaaaauaggg acguggccag gcacgguggc ucaugccugu aaucccagca cuuugggagg      300

ccgaggcagg cggcucacga ggucaggaga ucgagacuau ccuggcuaac acgguaaaac      360

ccugucucua cuaaaaguac aaaaaauuag cugggcgugg uggugggcac cuguaguccc      420

agcuacucgg gaggcugagg caggagaaag gcaugaaucc aagaggcaga gcuugcagug      480

agcugagauc acgccauugc acuccagccu gggcaacagu guuaagacuc ugucucaaau      540

auaaauaaau aaauaaauaa auaaauaaau aaauaaaaau aaagcgagau guugcccuca      600

aa                                                                     602


<210>  224
<211>  785
<212>  RNA
<213>  Homo sapiens

<400>  224
ggcccugccc cgucggacug cccccagaaa gccuccugcc cccugccagu gaaguccuuc       60

agugagcccc uccccagcca gcccuucccu ggccccgccg gauguauaaa uguaaaaaug      120

aaggaauuac auuuuauaug ugagcgagca agccggcaag cgagcacagu auuauuucuc      180

cauccccucc cugccugcuc cuuggcaccc ccaugcugcc uucagggaga caggcaggga      240

gggcuugggg cugcaccucc uacccuccca ccagaacgca ccccacuggg agagcuggug      300

gugcagccuu ccccucccug uauaagacac uuugccaagg cucuccccuc ucgccccauc      360

ccugcuugcc cgcucccaca gcuuccugag ggcuaauucu gggaagggag aguucuuugc      420

ugccccuguc uggaagacgu ggcucugggu gagguaggcg ggaaaggaug gaguguuuua      480

guucuugggg gaggccaccc caaaccccag ccccaacucc aggggcaccu augagauggc      540

caugcucaac cccccuccca gacaggcccu cccugucucc agggccccca ccgagguucc      600

cagggcugga gacuuccucu gguaaacauu ccuccagccu ccccuccccu ggggacgcca      660

aggagguggg ccacacccag gaagggaaag cgggcagccc cguuuugggg acgugaacgu      720

uuuaauaauu uuugcugaau uccuuuacaa cuaaauaaca cagauauugu uauaaauaaa      780

auugu                                                                  785


<210>  225
<211>  3001
<212>  RNA
<213>  Homo sapiens

<400>  225
auauuaagga ucaagcuguu agcuaauaau gccaccucug caguuuuggg aacaggcaaa       60

uaaaguauca guauacaugg ugauguacau cuguagcaaa gcucuuggag aaaaugaaga      120

cugaagaaag caaagcaaaa acuguauaga gagauuuuuc aaaagcagua aucccucaau      180

uuuaaaaaag gauugaaaau ucuaaauguc uuucugugca uauuuuuugu guuaggaauc      240

aaaaguauuu uauaaaagga gaaagaacag ccucauuuua gauguagucc uguuggauuu      300

uuuaugccuc cucaguaacc agaaauguuu uaaaaaacua aguguuuagg auuucaagac      360

aacauuauac auggcucuga aauaucugac acaauguaaa cauugcaggc accugcauuu      420

uauguuuuuu uuuucaacaa augugacuaa uuugaaacuu uuaugaacuu cugagcuguc      480

cccuugcaau ucaaccgcag uuugaauuaa ucauaucaaa ucaguuuuaa uuuuuuaaau      540

uguacuucag agucuauauu ucaagggcac auuuucucac uacuauuuua auacauuaaa      600

ggacuaaaua aucuuucaga gaugcuggaa acaaaucauu ugcuuuauau guuucauuag      660

aauaccaaug aaacauacaa cuugaaaauu aguaauagua uuuuugaaga ucccauuucu      720

aauuggagau cucuuuaauu ucgaucaacu uauaaugugu aguacuauau uaagugcacu      780

ugaguggaau ucaacauuug acuaauaaaa ugaguucauc auguuggcaa gugauguggc      840

aauuaucucu ggugacaaaa gaguaaaauc aaauauuucu gccuguuaca aauaucaagg      900

aagaccugcu acuaugaaau agaugacauu aaucugucuu cacuguuuau aauacggaug      960

gauuuuuuuu caaaucagug uguguuuuga ggucuuaugu aauugaugac auuugagaga     1020

aaugguggcu uuuuuuagcu accucuuugu ucauuuaagc accaguaaag aucaugucuu     1080

uuuauagaag uguagauuuu cuuugugacu uugcuaucgu gccuaaagcu cuaaauauag     1140

gugaaugugu gaugaauacu cagauuauuu gucucucuau auaauuaguu ugguacuaag     1200

uuucucaaaa aauuauuaac acaugaaaga caaucucuaa accagaaaaa gaaguaguac     1260

aaauuuuguu acuguaaugc ucgcguuuag ugaguuuaaa acacacagua ucuuuugguu     1320

uuauaaucag uuucuauuuu gcugugccug agauuaagau cuguguaugu gugugugugu     1380

gugugugcgu uuguguguua aagcagaaaa gacuuuuuua aaaguuuuaa gugauaaaug     1440

caauuuguua auugaucuua gaucacuagu aaacucaggg cugaauuaua ccauguauau     1500

ucuauuagaa gaaaguaaac accaucuuua uuccugcccu uuuucuucuc ucaaaguagu     1560

uguaguuaua ucuagaaaga agcaauuuug auuucuugaa aagguaguuc cugcacucag     1620

uuuaaacuaa aaauaaucau acuuggauuu uauuuauuuu ugucauagua aaaauuuuaa     1680

uuuauauaua uuuuuauuua guauuaucuu auucuuugcu auuugccaau ccuuugucau     1740

caauuguguu aaaugaauug aaaauucaug cccuguucau uuuauuuuac uuuauugguu     1800

aggauauuua aaggauuuuu guauauauaa uuucuuaaau uaauauucca aaagguuagu     1860

ggacuuagau uauaaauuau ggcaaaaauc uaaaaacaac aaaaaugauu uuuauacauu     1920

cuauuucauu auuccucuuu uuccaauaag ucauacaauu gguagauaug acuuauuuua     1980

uuuuuguauu auucacuaua ucuuuaugau auuuaaguau aaauaauuaa aaaaauuuau     2040

uguaccuuau agucugucac caaaaaaaaa aaauuaucug uagguaguga aaugcuaaug     2100

uugauuuguc uuuaagggcu uguuaacuau ccuuuauuuu cucauuuguc uuaaauuagg     2160

aguuuguguu uaaauuacuc aucuaagcaa aaaauguaua uaaaucccau uacuggguau     2220

auacccaaag gauuauaaau caugcugcua uaaagacaca ugcacacgua uguuuauugc     2280

agcacuauuc acaauagcaa agacuuggaa ccaacccaaa uguccaucaa ugauagacuu     2340

gauuaagaaa augugcacau auacaccaug gaauacuaug cagccauaaa aaaggaugag     2400

uucauguccu uuguagggac auggauaaag cuggaaacca ucauucugag caaacuauug     2460

caaggacaga aaaccaaaca cugcauguuc ucacucauag gugggaauug aacaaugaga     2520

acacuuggac acaagguggg gaacaccaca caccagggcc ugucaugggg uggggggagu     2580

ggggagggau agcauuagga gauauaccua auguaaauga ugaguuaaug ggugcagcac     2640

accaacaugg cacauguaua cauauguagc aaaccugcac guugugcaca uguacccuag     2700

aacuuaaagu auaauuaaaa aaaaaaagaa aacagaagcu auuuauaaag aaguuauuug     2760

cugaaauaaa ugugaucuuu cccauuaaaa aaauaaagaa auuuuggggu aaaaaaacac     2820

aauauauugu auucuugaaa aauucuaaga gaguggaugu gaaguguucu caccacaaaa     2880

gugauaacua auugagguaa ugcacauauu aauuagaaag auuuugucau uccacaaugu     2940

auauauacuu aaaaauaugu uauacacaau aaauacauac auuaaaaaau aaguaaaugu     3000

a                                                                     3001


<210>  226
<211>  1037
<212>  RNA
<213>  Homo sapiens

<400>  226
cccacccugc acgccggcac caaacccugu ccucccaccc cuccccacuc aucacuaaac       60

agaguaaaau gugaugcgaa uuuucccgac caaccugauu cgcuagauuu uuuuuaagga      120

aaagcuugga aagccaggac acaacgcugc ugccugcuuu gugcaggguc cuccggggcu      180

cagcccugag uuggcaucac cugcgcaggg cccucugggg cucagcccug agcuaguguc      240

accugcacag ggcccucuga ggcucagccc ugagcuggcg ucaccugugc agggcccucu      300

ggggcucagc ccugagcugg ccucaccugg guuccccacc ccgggcucuc cugcccugcc      360

cuccugcccg cccucccucc ugccugcgca gcuccuuccc uaggcaccuc ugugcugcau      420

cccaccagcc ugagcaagac gcccucucgg ggccugugcc gcacuagccu cccucuccuc      480

uguccccaua gcugguuuuu cccaccaauc cucaccuaac aguuacuuua caauuaaacu      540

caaagcaagc ucuucuccuc agcuuggggc agccauuggc cucugucucg uuuugggaaa      600

ccaaggucag gaggccguug cagacauaaa ucucggcgac ucggccccgu cuccugaggg      660

uccugcuggu gaccggccug gaccuuggcc cuacagcccu ggaggccgcu gcugaccagc      720

acugaccccg accucagaga guacucgcag gggcgcuggc ugcacucaag acccucgaga      780

uuaacggugc uaaccccguc ugcuccuccc ucccgcagag acuggggccu ggacuggaca      840

ugagagcccc uuggugccac agagggcugu gucuuacuag aaacaacgca aaccucuccu      900

uccucagaau agugaugugu ucgacguuuu aucaaaggcc cccuuucuau guucauguua      960

guuuugcucc uucuguguuu uuuucugaac cauauccaug uugcugacuu uuccaaauaa     1020

agguuuucac uccucuc                                                    1037


<210>  227
<211>  577
<212>  RNA
<213>  Homo sapiens

<400>  227
agaggccugc cuccagggcu ggacugaggc cugagcgcuc cugccgcaga gcuggccgcg       60

ccaaauaaug ucucugugag acucgagaac uuucauuuuu uuccaggcug guucggauuu      120

gggguggauu uugguuuugu uccccuccuc cacucucccc cacccccucc ccgcccuuuu      180

uuuuuuuuuu uuuuaaacug guauuuuauc uuugauucuc cuucagcccu caccccuggu      240

ucucaucuuu cuugaucaac aucuuuucuu gccucugucc ccuucucuca ucucuuagcu      300

ccccuccaac cuggggggca guggugugga gaagccacag gccugagauu ucaucugcuc      360

uccuuccugg agcccagagg agggcagcag aagggggugg ugucuccaac cccccagcac      420

ugaggaagaa cggggcucuu cucauuucac cccucccuuu cuccccugcc cccaggacug      480

ggccacuucu ggguggggca guggguccca gauuggcuca cacugagaau guaagaacua      540

caaacaaaau uucuauuaaa uuaaauuuug ugucucc                               577


<210>  228
<211>  2212
<212>  RNA
<213>  Homo sapiens

<400>  228
cucccuccau cccaaccugg cucccuccca cccaaccaac uuucccccca acccggaaac       60

agacaagcaa cccaaacuga acccccucaa aagccaaaaa augggagaca auuucacaug      120

gacuuuggaa aauauuuuuu uccuuugcau ucaucucuca aacuuaguuu uuaucuuuga      180

ccaaccgaac augaccaaaa accaaaagug cauucaaccu uaccaaaaaa aaaaaaaaaa      240

aaagaauaaa uaaauaacuu uuuaaaaaag gaagcuuggu ccacuugcuu gaagacccau      300

gcggggguaa gucccuuucu gcccguuggg cuuaugaaac cccaaugcug cccuuucugc      360

uccuuucucc acaccccccu uggggccucc ccuccacucc uucccaaauc ugucucccca      420

gaagacacag gaaacaaugu auugucugcc cagcaaucaa aggcaaugcu caaacaccca      480

aguggccccc acccucagcc cgcuccugcc cgcccagcac ccccaggccc ugggggaccu      540

gggguucuca gacugccaaa gaagccuugc caucuggcgc ucccauggcu cuugcaacau      600

cuccccuucg uuuuugaggg ggucaugccg ggggagccac cagccccuca cuggguucgg      660

aggagaguca ggaagggcca cgacaaagca gaaacaucgg auuuggggaa cgcgugucaa      720

ucccuugugc cgcagggcug ggcgggagag acuguucugu uccuugugua acuguguugc      780

ugaaagacua ccucguucuu gucuugaugu gucaccgggg caacugccug ggggcgggga      840

ugggggcagg guggaagcgg cuccccauuu uauaccaaag gugcuacauc uaugugaugg      900

gugggguggg gagggaauca cuggugcuau agaaauugag augccccccc aggccagcaa      960

auguuccuuu uuguucaaag ucuauuuuua uuccuugaua uuuuucuuuu uuuuuuuuuu     1020

uuuuugugga uggggacuug ugaauuuuuc uaaaggugcu auuuaacaug ggaggagagc     1080

gugugcggcu ccagcccagc ccgcugcuca cuuuccaccc ucucuccacc ugccucuggc     1140

uucucaggcc ucugcucucc gaccucucuc cucugaaacc cuccuccaca gcugcagccc     1200

auccucccgg cucccuccua gucuguccug cguccucugu ccccggguuu cagagacaac     1260

uucccaaagc acaaagcagu uuuucccccu agggguggga ggaagcaaaa gacucuguac     1320

cuauuuugua uguguauaau aauuugagau guuuuuaauu auuuugauug cuggaauaaa     1380

gcauguggaa augacccaaa cauaauccgc aguggccucc uaauuuccuu cuuuggaguu     1440

gggggagggg uagacauggg gaaggggcuu uggggugaug ggcuugccuu ccauuccugc     1500

ccuuucccuc cccacuauuc ucuucuagau cccuccauaa ccccacuccc cuuucucuca     1560

cccuucuuau accgcaaacc uuucuacuuc cucuuucauu uucuauucuu gcaauuuccu     1620

ugcaccuuuu ccaaauccuc uucuccccug caauaccaua caggcaaucc acgugcacaa     1680

cacacacaca cacucuucac aucugggguu guccaaaccu cauacccacu ccccuucaag     1740

cccauccacu cuccaccccc uggaugcccu gcacuuggug gcggugggau gcucauggau     1800

acugggaggg ugaggggagu ggaacccgug aggaggaccu gggggccucu ccuugaacug     1860

acaugaaggg ucaucuggcc ucugcucccu ucucacccac gcugaccucc ugccgaagga     1920

gcaacgcaac aggagagggg ucugcugagc cuggcgaggg ucugggaggg accaggagga     1980

aggcgugcuc ccugcucgcu guccuggccc ugggggagug agggagacag acaccuggga     2040

gagcuguggg gaaggcacuc gcaccgugcu cuugggaagg aaggagaccu ggcccugcuc     2100

accacggacu gggugccucg accuccugaa uccccagaac acaacccccc ugggcugggg     2160

uggucugggg aaccaucgug cccccgccuc ccgccuacuc cuuuuuaagc uu             2212


<210>  229
<211>  729
<212>  RNA
<213>  Homo sapiens

<400>  229
uuggccaggc cugacccucu uggaccuuuc uucuuugccg acaaccacug cccagcagcc       60

ucugggaccu cgggguccca gggaacccag uccagccucc uggcuguuga cuucccauug      120

cucuuggagc caccaaucaa agagauucaa agagauuccu gcaggccaga ggcggaacac      180

accuuuaugg cuggggcucu ccgugguguu cuggacccag ccccuggaga caccauucac      240

uuuuacugcu uuguagugac ucgugcucuc caaccugucu uccugaaaaa ccaaggcccc      300

cuucccccac cucuuccaug gggugagacu ugagcagaac aggggcuucc ccaaguugcc      360

cagaaagacu gucuggguga gaagccaugg ccagagcuuc ucccaggcac agguguugca      420

ccagggacuu cugcuucaag uuuuggggua aagacaccug gaucagacuc caagggcugc      480

ccugagucug ggacuucugc cuccauggcu ggucaugaga gcaaaccgua guccccugga      540

gacagcgacu ccagagaacc ucuugggaga cagaagaggc aucugugcac agcucgaucu      600

ucuacuugcc uguggggagg ggagugacag guccacacac cacacugggu cacccugucc      660

uggaugccuc ugaagagagg gacagaccgu cagaaacugg agaguuucua uuaaagguca      720

uuuaaacca                                                              729


<210>  230
<211>  847
<212>  RNA
<213>  Homo sapiens

<400>  230
uccuccggga ccccagcccu caggauuccu gaugcuccaa ggcgacugau gggcgcugga       60

ugaaguggca cagucagcuu cccugggggc uggugucaug uugggcuccu ggggcggggg      120

cacggccugg cauuucacgc auugcugcca ccccaggucc accugucucc acuuucacag      180

ccuccaaguc uguggcucuu cccuucuguc cuccgagggg cuugccuucu cucgugucca      240

gugaggugcu cagugaucgg cuuaacuuag agaagcccgc ccccuccccu ucuccgucug      300

ucccaagagg gucugcucug agccugcguu ccuagguggc ucggccucag cugccugggu      360

uguggccgcc cuagcauccu guaugcccac agcuacugga auccccgcug cugcuccggg      420

ccaagcuucu gguugauuaa ugagggcaug gggugguccc ucaagaccuu ccccuaccuu      480

uuguggaacc agugaugccu caaagacagu guccccucca cagcugggug ccaggggcag      540

gggauccuca guauagccgg ugaacccuga uaccaggagc cugggccucc cugaaccccu      600

ggcuuccagc caucucaucg ccagccuccu ccuggaccuc uuggccccca gccccuuccc      660

cacacagccc cagaaggguc ccagagcuga ccccacucca ggaccuaggc ccagccccuc      720

agccucaucu ggagccccug aagaccaguc ccacccaccu uucuggccuc aucugacacu      780

gcuccgcauc cugcugugug uccuguucca uguuccgguu ccauccaaau acacuuucug      840

gaacaaa                                                                847


<210>  231
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  231
gcuggagccu cgguggccau gcuucuugcc ccuugggccu ccccccagcc ccuccucccc       60

uuccugcacc cguacccccg uggucuuuga auaaagucug agugggcggc                 110


<210>  232
<211>  116
<212>  RNA
<213>  Homo sapiens

<400>  232
uaauaggcug gagccucggu ggccaugcuu cuugccccuu gggccucccc ccagccccuc       60

cuccccuucc ugcacccgua cccccguggu cuuugaauaa agucugagug ggcggc          116


<210>  233
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  233
attgggcacc cgtaaggg                                                     18


<210>  234
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  234

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  235
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  236
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  236

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  237
<211>  325
<212>  DNA
<213>  Homo sapiens

<400>  237
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agcagcttct tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc      300

caagggacca aggtggaaat caaac                                            325


<210>  238
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  238

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  239
<211>  355
<212>  DNA
<213>  Homo sapiens

<400>  239
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaagcaa taaacactac      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc      300

tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcag           355


<210>  240
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  240

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  241
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  241
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca      120

gagaaagccc ctaagtccct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgccaacag tataatagtt accctccgac gttcggccaa      300

gggaccaagg tggaaatcaa ac                                               322


<210>  242
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  242

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  243
<211>  358
<212>  DNA
<213>  Homo sapiens

<400>  243
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt tttactgtgc gagagctccc      300

aattatattg gtgcttttga tgtctggggc caagggacaa tggtcaccgt ctcttcag        358


<210>  244
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  244

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys 
                85                  90                  95      


Ala Arg Ala Pro Asn Tyr Ile Gly Ala Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  245
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  245

Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 
1               5                   10          


<210>  246
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  246

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  247
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  247

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  248
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  248

Ser Tyr Thr Met His 
1               5   


<210>  249
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  249

Phe Ile Ser Tyr Asp Gly Ser Asn Lys His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  250
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  250

Thr Gly Trp Leu Gly Pro Phe Asp Tyr 
1               5                   


<210>  251
<211>  1637
<212>  DNA
<213>  Homo sapiens

<400>  251
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccccgcccag ctgctgtttc      120

tgctgctgct gtggctgccc gacaccaccg gccaggtgca gctggtggag agcggcggcg      180

gcgtggtgca gcccggcaga agcctgagac tgagctgcgc cgccagcggc tttaccttca      240

gcagctacac catgcactgg gtgcggcagg cccctggcaa gggactggag tgggtgacct      300

tcataagcta cgacggcaat aacaagtatt acgccgacag cgtgaagggc agattcacca      360

tcagcagaga caacagcaag aataccctgt acctgcagat gaatagcctg agagccgagg      420

acaccgccat ctactactgc gccagaacag gctggctggg cccattcgac tactggggcc      480

agggcacact ggtgacagtc tccagcgcta gcactaaggg tcccagcgtg ttccccctgg      540

ccccgagcag caaaagcacc agcggcggca ccgccgccct gggctgcctg gtcaaggact      600

acttccccga gcccgtgacc gtgtcttgga actccggggc cctgaccagc ggggtacaca      660

ccttccccgc cgtgctgcag agcagcggcc tgtattccct gagctccgtg gtgaccgtcc      720

ctagctccag cctgggcacc cagacctaca tctgcaacgt gaaccacaag ccctccaaca      780

ccaaagtgga caagcgcgtg gagcccaaga gttgcgacaa aacccacacc tgtcctccct      840

gcccggctcc tgagctgttg ggcggaccca gcgtcttcct gttcccccca aagcccaagg      900

acaccctgat gatcagccgg acccccgagg tgacttgcgt ggtggtcgac gtgagccacg      960

aggacccaga ggtgaagttc aactggtacg tggacggcgt cgaggtgcac aacgccaaga     1020

ccaagcctag agaggagcag tacaacagca cctacagggt ggtgagcgtg ctgaccgtgc     1080

tgcatcagga ctggctgaac ggcaaagagt acaagtgcaa ggtgtcaaat aaggccctgc     1140

ccgcacccat tgagaagact atcagcaagg ccaagggcca gcccagagag ccacaggtgt     1200

acaccctgcc ccccagcaga gaggagatga ccaagaacca ggtgagcctc acctgcctgg     1260

tcaagggctt ttaccccagc gacatcgccg ttgagtggga gagcaatggc cagcccgaga     1320

acaactacaa gaccaccccc ccggtgctgg actccgacgg cagctttttc ctgtacagca     1380

agctgaccgt ggacaagagc agatggcagc agggcaacgt gttcagctgc agcgtgatgc     1440

acgaggccct gcacaaccac tacacccaga agtctctgag cctgagcccc ggcaagtgat     1500

aataggctgg agcctcggtg gccatgcttc ttgccccttg ggcctccccc cagcccctcc     1560

tccccttcct gcacccgtac cccccaaaca ccattgtcac actccagtgg tctttgaata     1620

aagtctgagt gggcggc                                                    1637


<210>  252
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  252

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  253
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  253
atggagaccc ccgcccagct gctgtttctg ctgctgctgt ggctgcccga caccaccggc       60

caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcagaag cctgagactg      120

agctgcgccg ccagcggctt taccttcagc agctacacca tgcactgggt gcggcaggcc      180

cctggcaagg gactggagtg ggtgaccttc ataagctacg acggcaataa caagtattac      240

gccgacagcg tgaagggcag attcaccatc agcagagaca acagcaagaa taccctgtac      300

ctgcagatga atagcctgag agccgaggac accgccatct actactgcgc cagaacaggc      360

tggctgggcc cattcgacta ctggggccag ggcacactgg tgacagtctc cagcgctagc      420

actaagggtc ccagcgtgtt ccccctggcc ccgagcagca aaagcaccag cggcggcacc      480

gccgccctgg gctgcctggt caaggactac ttccccgagc ccgtgaccgt gtcttggaac      540

tccggggccc tgaccagcgg ggtacacacc ttccccgccg tgctgcagag cagcggcctg      600

tattccctga gctccgtggt gaccgtccct agctccagcc tgggcaccca gacctacatc      660

tgcaacgtga accacaagcc ctccaacacc aaagtggaca agcgcgtgga gcccaagagt      720

tgcgacaaaa cccacacctg tcctccctgc ccggctcctg agctgttggg cggacccagc      780

gtcttcctgt tccccccaaa gcccaaggac accctgatga tcagccggac ccccgaggtg      840

acttgcgtgg tggtcgacgt gagccacgag gacccagagg tgaagttcaa ctggtacgtg      900

gacggcgtcg aggtgcacaa cgccaagacc aagcctagag aggagcagta caacagcacc      960

tacagggtgg tgagcgtgct gaccgtgctg catcaggact ggctgaacgg caaagagtac     1020

aagtgcaagg tgtcaaataa ggccctgccc gcacccattg agaagactat cagcaaggcc     1080

aagggccagc ccagagagcc acaggtgtac accctgcccc ccagcagaga ggagatgacc     1140

aagaaccagg tgagcctcac ctgcctggtc aagggctttt accccagcga catcgccgtt     1200

gagtgggaga gcaatggcca gcccgagaac aactacaaga ccaccccccc ggtgctggac     1260

tccgacggca gctttttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

tctctgagcc tgagccccgg caag                                            1404


<210>  254
<211>  1696
<212>  DNA
<213>  Homo sapiens

<400>  254
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccccgc       60

ccagctgctg tttctgctgc tgctgtggct gcccgacacc accggccagg tgcagctggt      120

ggagagcggc ggcggcgtgg tgcagcccgg cagaagcctg agactgagct gcgccgccag      180

cggctttacc ttcagcagct acaccatgca ctgggtgcgg caggcccctg gcaagggact      240

ggagtgggtg accttcataa gctacgacgg caataacaag tattacgccg acagcgtgaa      300

gggcagattc accatcagca gagacaacag caagaatacc ctgtacctgc agatgaatag      360

cctgagagcc gaggacaccg ccatctacta ctgcgccaga acaggctggc tgggcccatt      420

cgactactgg ggccagggca cactggtgac agtctccagc gctagcacta agggtcccag      480

cgtgttcccc ctggccccga gcagcaaaag caccagcggc ggcaccgccg ccctgggctg      540

cctggtcaag gactacttcc ccgagcccgt gaccgtgtct tggaactccg gggccctgac      600

cagcggggta cacaccttcc ccgccgtgct gcagagcagc ggcctgtatt ccctgagctc      660

cgtggtgacc gtccctagct ccagcctggg cacccagacc tacatctgca acgtgaacca      720

caagccctcc aacaccaaag tggacaagcg cgtggagccc aagagttgcg acaaaaccca      780

cacctgtcct ccctgcccgg ctcctgagct gttgggcgga cccagcgtct tcctgttccc      840

cccaaagccc aaggacaccc tgatgatcag ccggaccccc gaggtgactt gcgtggtggt      900

cgacgtgagc cacgaggacc cagaggtgaa gttcaactgg tacgtggacg gcgtcgaggt      960

gcacaacgcc aagaccaagc ctagagagga gcagtacaac agcacctaca gggtggtgag     1020

cgtgctgacc gtgctgcatc aggactggct gaacggcaaa gagtacaagt gcaaggtgtc     1080

aaataaggcc ctgcccgcac ccattgagaa gactatcagc aaggccaagg gccagcccag     1140

agagccacag gtgtacaccc tgccccccag cagagaggag atgaccaaga accaggtgag     1200

cctcacctgc ctggtcaagg gcttttaccc cagcgacatc gccgttgagt gggagagcaa     1260

tggccagccc gagaacaact acaagaccac ccccccggtg ctggactccg acggcagctt     1320

tttcctgtac agcaagctga ccgtggacaa gagcagatgg cagcagggca acgtgttcag     1380

ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc cagaagtctc tgagcctgag     1440

ccccggcaag tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc     1500

cccccagccc ctcctcccct tcctgcaccc gtacccccca aacaccattg tcacactcca     1560

gtggtctttg aataaagtct gagtgggcgg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa atctag                                                     1696


<210>  255
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  255

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  256
<211>  1637
<212>  DNA
<213>  Homo sapiens

<400>  256
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccccgcacag ctgctcttcc      120

tgctgctgct gtggctgccc gacaccaccg gacaggtgca gctggtagag agcggcggcg      180

gcgtagtgca gcccggcaga agcctgaggc tgtcctgcgc cgccagtggc tttaccttca      240

gcagctacac catgcactgg gtgagacagg ctccaggcaa aggcctggag tgggtgactt      300

tcatcagcta tgacggaaac aacaagtact acgccgacag cgtgaagggc aggttcacca      360

tctccagaga caactcgaaa aacaccctgt acctgcagat gaacagcctg agagccgagg      420

ataccgccat ctactactgc gcccgcacag gctggctggg cccttttgac tactggggcc      480

aaggcacact ggttacagtg agcagcgcct caaccaaggg ccccagtgtg ttccccctgg      540

caccctcgag caagagcacc tccggcggca ccgccgccct gggctgtctc gtgaaggact      600

acttccccga gcccgtcacc gtgagctgga acagcggcgc cctgacctca ggcgtgcaca      660

ccttccccgc cgtgctccag tctagcggcc tgtactccct gtcaagcgtt gtgacagtgc      720

ccagcagcag cctgggcacc cagacataca tctgcaatgt gaaccacaaa ccctccaaca      780

ccaaggtgga caagagggtg gagccaaagt cttgcgacaa gacccacacc tgccctccct      840

gccccgcccc cgagctgctg ggcggcccca gcgtgttcct gtttcccccc aagcctaagg      900

acacactgat gatcagcaga acccctgagg tgacctgtgt ggtggtggac gtgagccacg      960

aggaccccga ggtgaagttt aactggtacg tggacggcgt ggaggtgcac aacgccaaga     1020

ccaagcccag agaagagcag tacaacagca cctacagagt ggtaagcgtg ctgaccgtgc     1080

tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtgtccaat aaggcccttc     1140

ccgcccccat cgagaagacc atctccaagg ccaagggcca gcctagagag ccccaagtgt     1200

acaccctgcc ccccagcagg gaggagatga ccaagaatca ggtgagcctg acctgcctgg     1260

tgaagggatt ttaccccagc gacatcgccg tggagtggga gagcaacggc cagcccgaga     1320

acaactacaa gaccaccccc cccgtgctgg acagcgacgg ctctttcttc ctgtacagca     1380

agctgaccgt ggacaagtcc aggtggcagc agggcaacgt gttcagctgc agcgtgatgc     1440

acgaggccct gcacaaccac tacacccaga agagcttgtc cctgagcccc ggcaagtgat     1500

aataggctgg agcctcggtg gccatgcttc ttgccccttg ggcctccccc cagcccctcc     1560

tccccttcct gcacccgtac cccccaaaca ccattgtcac actccagtgg tctttgaata     1620

aagtctgagt gggcggc                                                    1637


<210>  257
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  257

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  258
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  258
atggagaccc ccgcacagct gctcttcctg ctgctgctgt ggctgcccga caccaccgga       60

caggtgcagc tggtagagag cggcggcggc gtagtgcagc ccggcagaag cctgaggctg      120

tcctgcgccg ccagtggctt taccttcagc agctacacca tgcactgggt gagacaggct      180

ccaggcaaag gcctggagtg ggtgactttc atcagctatg acggaaacaa caagtactac      240

gccgacagcg tgaagggcag gttcaccatc tccagagaca actcgaaaaa caccctgtac      300

ctgcagatga acagcctgag agccgaggat accgccatct actactgcgc ccgcacaggc      360

tggctgggcc cttttgacta ctggggccaa ggcacactgg ttacagtgag cagcgcctca      420

accaagggcc ccagtgtgtt ccccctggca ccctcgagca agagcacctc cggcggcacc      480

gccgccctgg gctgtctcgt gaaggactac ttccccgagc ccgtcaccgt gagctggaac      540

agcggcgccc tgacctcagg cgtgcacacc ttccccgccg tgctccagtc tagcggcctg      600

tactccctgt caagcgttgt gacagtgccc agcagcagcc tgggcaccca gacatacatc      660

tgcaatgtga accacaaacc ctccaacacc aaggtggaca agagggtgga gccaaagtct      720

tgcgacaaga cccacacctg ccctccctgc cccgcccccg agctgctggg cggccccagc      780

gtgttcctgt ttccccccaa gcctaaggac acactgatga tcagcagaac ccctgaggtg      840

acctgtgtgg tggtggacgt gagccacgag gaccccgagg tgaagtttaa ctggtacgtg      900

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aagagcagta caacagcacc      960

tacagagtgg taagcgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tgtccaataa ggcccttccc gcccccatcg agaagaccat ctccaaggcc     1080

aagggccagc ctagagagcc ccaagtgtac accctgcccc ccagcaggga ggagatgacc     1140

aagaatcagg tgagcctgac ctgcctggtg aagggatttt accccagcga catcgccgtg     1200

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc cgtgctggac     1260

agcgacggct ctttcttcct gtacagcaag ctgaccgtgg acaagtccag gtggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacccagaag     1380

agcttgtccc tgagccccgg caag                                            1404


<210>  259
<211>  1696
<212>  DNA
<213>  Homo sapiens

<400>  259
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccccgc       60

acagctgctc ttcctgctgc tgctgtggct gcccgacacc accggacagg tgcagctggt      120

agagagcggc ggcggcgtag tgcagcccgg cagaagcctg aggctgtcct gcgccgccag      180

tggctttacc ttcagcagct acaccatgca ctgggtgaga caggctccag gcaaaggcct      240

ggagtgggtg actttcatca gctatgacgg aaacaacaag tactacgccg acagcgtgaa      300

gggcaggttc accatctcca gagacaactc gaaaaacacc ctgtacctgc agatgaacag      360

cctgagagcc gaggataccg ccatctacta ctgcgcccgc acaggctggc tgggcccttt      420

tgactactgg ggccaaggca cactggttac agtgagcagc gcctcaacca agggccccag      480

tgtgttcccc ctggcaccct cgagcaagag cacctccggc ggcaccgccg ccctgggctg      540

tctcgtgaag gactacttcc ccgagcccgt caccgtgagc tggaacagcg gcgccctgac      600

ctcaggcgtg cacaccttcc ccgccgtgct ccagtctagc ggcctgtact ccctgtcaag      660

cgttgtgaca gtgcccagca gcagcctggg cacccagaca tacatctgca atgtgaacca      720

caaaccctcc aacaccaagg tggacaagag ggtggagcca aagtcttgcg acaagaccca      780

cacctgccct ccctgccccg cccccgagct gctgggcggc cccagcgtgt tcctgtttcc      840

ccccaagcct aaggacacac tgatgatcag cagaacccct gaggtgacct gtgtggtggt      900

ggacgtgagc cacgaggacc ccgaggtgaa gtttaactgg tacgtggacg gcgtggaggt      960

gcacaacgcc aagaccaagc ccagagaaga gcagtacaac agcacctaca gagtggtaag     1020

cgtgctgacc gtgctgcacc aggactggct gaacggcaag gagtacaagt gcaaggtgtc     1080

caataaggcc cttcccgccc ccatcgagaa gaccatctcc aaggccaagg gccagcctag     1140

agagccccaa gtgtacaccc tgccccccag cagggaggag atgaccaaga atcaggtgag     1200

cctgacctgc ctggtgaagg gattttaccc cagcgacatc gccgtggagt gggagagcaa     1260

cggccagccc gagaacaact acaagaccac cccccccgtg ctggacagcg acggctcttt     1320

cttcctgtac agcaagctga ccgtggacaa gtccaggtgg cagcagggca acgtgttcag     1380

ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc cagaagagct tgtccctgag     1440

ccccggcaag tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc     1500

cccccagccc ctcctcccct tcctgcaccc gtacccccca aacaccattg tcacactcca     1560

gtggtctttg aataaagtct gagtgggcgg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa atctag                                                     1696


<210>  260
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  260

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  261
<211>  1637
<212>  DNA
<213>  Homo sapiens

<400>  261
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac acccgcccag ctgctcttcc      120

tgctgctgtt gtggctgccc gacaccaccg gacaggttca gctggtggaa agcggcggcg      180

gcgtggtgca gccaggcagg agcctgagac tgtcctgcgc cgcaagcggc ttcaccttct      240

ccagctatac catgcactgg gtgaggcagg cccccggcaa aggcctggag tgggtgacgt      300

tcatctccta cgacggtaac aataagtact acgccgacag cgtgaaaggc aggttcacca      360

tcagcagaga caacagcaag aacactctgt acctgcagat gaactccctc cgtgccgagg      420

acaccgccat ctactactgc gccaggaccg gctggctggg ccccttcgac tactgggggc      480

agggcaccct ggtcaccgtg agtagcgcca gcaccaaggg acctagcgtg ttccccctgg      540

cccccagcag caagtccacc agcggcggca ccgccgccct ggggtgcctg gtgaaggact      600

acttccccga acccgtgacc gtgtcttgga acagcggggc cctgacctcc ggcgtgcaca      660

ccttccccgc cgtgctgcag agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc      720

ctagctctag cctcggcacc cagacttaca tctgcaacgt gaaccataag cccagcaaca      780

caaaggtcga taagcgagtg gagcccaaga gctgcgacaa gacccacacc tgccccccct      840

gccccgcccc cgagctgctg ggcggaccca gcgtgttcct gttcccccct aaacccaaag      900

acaccctgat gatcagcaga acccccgagg tgacctgtgt ggtggtggac gtcagccacg      960

aggaccccga ggtgaagttc aactggtacg tggacggcgt tgaggtgcac aacgccaaga     1020

ccaaacccag ggaggagcag tacaatagca cctatagagt ggtgagcgtg ctgaccgtgc     1080

tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtgagcaac aaggccttac     1140

ccgcccccat cgagaagacc atctccaagg ccaagggcca gcccagagag ccccaggtgt     1200

acaccctgcc tcccagcaga gaggagatga ctaagaacca ggtcagcctt acctgcctgg     1260

tgaagggctt ttacccctca gacatcgccg tggaatggga gagcaacggc cagcccgaaa     1320

ataactacaa gacaacccct cccgtgctgg acagcgacgg gagcttcttc ttgtacagca     1380

agctcaccgt ggacaagagc agatggcagc agggcaacgt gttcagctgc agcgtgatgc     1440

atgaggccct gcacaaccac tatacacaga agagcctgag cctgagcccc ggcaagtgat     1500

aataggctgg agcctcggtg gccatgcttc ttgccccttg ggcctccccc cagcccctcc     1560

tccccttcct gcacccgtac cccccaaaca ccattgtcac actccagtgg tctttgaata     1620

aagtctgagt gggcggc                                                    1637


<210>  262
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  262

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  263
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  263
atggagacac ccgcccagct gctcttcctg ctgctgttgt ggctgcccga caccaccgga       60

caggttcagc tggtggaaag cggcggcggc gtggtgcagc caggcaggag cctgagactg      120

tcctgcgccg caagcggctt caccttctcc agctatacca tgcactgggt gaggcaggcc      180

cccggcaaag gcctggagtg ggtgacgttc atctcctacg acggtaacaa taagtactac      240

gccgacagcg tgaaaggcag gttcaccatc agcagagaca acagcaagaa cactctgtac      300

ctgcagatga actccctccg tgccgaggac accgccatct actactgcgc caggaccggc      360

tggctgggcc ccttcgacta ctgggggcag ggcaccctgg tcaccgtgag tagcgccagc      420

accaagggac ctagcgtgtt ccccctggcc cccagcagca agtccaccag cggcggcacc      480

gccgccctgg ggtgcctggt gaaggactac ttccccgaac ccgtgaccgt gtcttggaac      540

agcggggccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      600

tacagcctga gcagcgtggt gaccgtgcct agctctagcc tcggcaccca gacttacatc      660

tgcaacgtga accataagcc cagcaacaca aaggtcgata agcgagtgga gcccaagagc      720

tgcgacaaga cccacacctg ccccccctgc cccgcccccg agctgctggg cggacccagc      780

gtgttcctgt tcccccctaa acccaaagac accctgatga tcagcagaac ccccgaggtg      840

acctgtgtgg tggtggacgt cagccacgag gaccccgagg tgaagttcaa ctggtacgtg      900

gacggcgttg aggtgcacaa cgccaagacc aaacccaggg aggagcagta caatagcacc      960

tatagagtgg tgagcgtgct gaccgtgctg caccaggact ggctgaatgg caaggagtac     1020

aagtgcaagg tgagcaacaa ggccttaccc gcccccatcg agaagaccat ctccaaggcc     1080

aagggccagc ccagagagcc ccaggtgtac accctgcctc ccagcagaga ggagatgact     1140

aagaaccagg tcagccttac ctgcctggtg aagggctttt acccctcaga catcgccgtg     1200

gaatgggaga gcaacggcca gcccgaaaat aactacaaga caacccctcc cgtgctggac     1260

agcgacggga gcttcttctt gtacagcaag ctcaccgtgg acaagagcag atggcagcag     1320

ggcaacgtgt tcagctgcag cgtgatgcat gaggccctgc acaaccacta tacacagaag     1380

agcctgagcc tgagccccgg caag                                            1404


<210>  264
<211>  1696
<212>  DNA
<213>  Homo sapiens

<400>  264
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacacccgc       60

ccagctgctc ttcctgctgc tgttgtggct gcccgacacc accggacagg ttcagctggt      120

ggaaagcggc ggcggcgtgg tgcagccagg caggagcctg agactgtcct gcgccgcaag      180

cggcttcacc ttctccagct ataccatgca ctgggtgagg caggcccccg gcaaaggcct      240

ggagtgggtg acgttcatct cctacgacgg taacaataag tactacgccg acagcgtgaa      300

aggcaggttc accatcagca gagacaacag caagaacact ctgtacctgc agatgaactc      360

cctccgtgcc gaggacaccg ccatctacta ctgcgccagg accggctggc tgggcccctt      420

cgactactgg gggcagggca ccctggtcac cgtgagtagc gccagcacca agggacctag      480

cgtgttcccc ctggccccca gcagcaagtc caccagcggc ggcaccgccg ccctggggtg      540

cctggtgaag gactacttcc ccgaacccgt gaccgtgtct tggaacagcg gggccctgac      600

ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgagcag      660

cgtggtgacc gtgcctagct ctagcctcgg cacccagact tacatctgca acgtgaacca      720

taagcccagc aacacaaagg tcgataagcg agtggagccc aagagctgcg acaagaccca      780

cacctgcccc ccctgccccg cccccgagct gctgggcgga cccagcgtgt tcctgttccc      840

ccctaaaccc aaagacaccc tgatgatcag cagaaccccc gaggtgacct gtgtggtggt      900

ggacgtcagc cacgaggacc ccgaggtgaa gttcaactgg tacgtggacg gcgttgaggt      960

gcacaacgcc aagaccaaac ccagggagga gcagtacaat agcacctata gagtggtgag     1020

cgtgctgacc gtgctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtgag     1080

caacaaggcc ttacccgccc ccatcgagaa gaccatctcc aaggccaagg gccagcccag     1140

agagccccag gtgtacaccc tgcctcccag cagagaggag atgactaaga accaggtcag     1200

ccttacctgc ctggtgaagg gcttttaccc ctcagacatc gccgtggaat gggagagcaa     1260

cggccagccc gaaaataact acaagacaac ccctcccgtg ctggacagcg acgggagctt     1320

cttcttgtac agcaagctca ccgtggacaa gagcagatgg cagcagggca acgtgttcag     1380

ctgcagcgtg atgcatgagg ccctgcacaa ccactataca cagaagagcc tgagcctgag     1440

ccccggcaag tgataatagg ctggagcctc ggtggccatg cttcttgccc cttgggcctc     1500

cccccagccc ctcctcccct tcctgcaccc gtacccccca aacaccattg tcacactcca     1560

gtggtctttg aataaagtct gagtgggcgg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa atctag                                                     1696


<210>  265
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  265

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  266
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  266
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccccgcccag ctgctgttcc      120

tgctgctgct gtggctgccc gacaccactg gcgagatcgt gctgacccag tctcccggca      180

cactgtctct gtctcccggc gagcgcgcaa ctctgagctg cagggcgagc cagagcgtgg      240

gcagcagcta cctggcctgg taccagcaga agccaggcca ggcccctagg ctgctgatct      300

acggcgcctt ctcccgggcg accgggatcc ccgacagatt cagcggcagc ggctccggca      360

ccgacttcac cctgacaatc agcagactgg agcccgagga cttcgccgtg tactactgcc      420

agcagtacgg cagcagcccc tggacatttg gccagggcac taaggtggag atcaagagaa      480

ccgtggccgc ccccagcgtg ttcatcttcc cccccagcga tgagcagctg aagagcggca      540

ccgcctccgt ggtctgcctg ctgaacaact tctaccccag agaggccaag gttcagtgga      600

aggtggacaa cgccctgcag agcggcaaca gccaggagtc tgtgactgaa caggacagca      660

aggacagcac atacagcctg agcagcaccc tcaccctgtc caaggccgat tacgagaagc      720

acaaggtgta cgcctgcgag gtgacccacc aaggcctgag cagccccgtg accaagagct      780

tcaacagagg cgagtgctga taataggctg gagcctcggt ggccatgctt cttgcccctt      840

gggcctcccc ccagcccctc ctccccttcc tgcacccgta ccccccaaac accattgtca      900

cactccagtg gtctttgaat aaagtctgag tgggcggc                              938


<210>  267
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  268
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  268
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga caccactggc       60

gagatcgtgc tgacccagtc tcccggcaca ctgtctctgt ctcccggcga gcgcgcaact      120

ctgagctgca gggcgagcca gagcgtgggc agcagctacc tggcctggta ccagcagaag      180

ccaggccagg cccctaggct gctgatctac ggcgccttct cccgggcgac cgggatcccc      240

gacagattca gcggcagcgg ctccggcacc gacttcaccc tgacaatcag cagactggag      300

cccgaggact tcgccgtgta ctactgccag cagtacggca gcagcccctg gacatttggc      360

cagggcacta aggtggagat caagagaacc gtggccgccc ccagcgtgtt catcttcccc      420

cccagcgatg agcagctgaa gagcggcacc gcctccgtgg tctgcctgct gaacaacttc      480

taccccagag aggccaaggt tcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagtctg tgactgaaca ggacagcaag gacagcacat acagcctgag cagcaccctc      600

accctgtcca aggccgatta cgagaagcac aaggtgtacg cctgcgaggt gacccaccaa      660

ggcctgagca gccccgtgac caagagcttc aacagaggcg agtgc                      705


<210>  269
<211>  997
<212>  DNA
<213>  Homo sapiens

<400>  269
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccccgc       60

ccagctgctg ttcctgctgc tgctgtggct gcccgacacc actggcgaga tcgtgctgac      120

ccagtctccc ggcacactgt ctctgtctcc cggcgagcgc gcaactctga gctgcagggc      180

gagccagagc gtgggcagca gctacctggc ctggtaccag cagaagccag gccaggcccc      240

taggctgctg atctacggcg ccttctcccg ggcgaccggg atccccgaca gattcagcgg      300

cagcggctcc ggcaccgact tcaccctgac aatcagcaga ctggagcccg aggacttcgc      360

cgtgtactac tgccagcagt acggcagcag cccctggaca tttggccagg gcactaaggt      420

ggagatcaag agaaccgtgg ccgcccccag cgtgttcatc ttccccccca gcgatgagca      480

gctgaagagc ggcaccgcct ccgtggtctg cctgctgaac aacttctacc ccagagaggc      540

caaggttcag tggaaggtgg acaacgccct gcagagcggc aacagccagg agtctgtgac      600

tgaacaggac agcaaggaca gcacatacag cctgagcagc accctcaccc tgtccaaggc      660

cgattacgag aagcacaagg tgtacgcctg cgaggtgacc caccaaggcc tgagcagccc      720

cgtgaccaag agcttcaaca gaggcgagtg ctgataatag gctggagcct cggtggccat      780

gcttcttgcc ccttgggcct ccccccagcc cctcctcccc ttcctgcacc cgtacccccc      840

aaacaccatt gtcacactcc agtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatctag                               997


<210>  270
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  270

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  271
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  271
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccccgcccag ctgctcttcc      120

tgctgctgct gtggctgcct gacaccaccg gcgagatcgt gctgacccaa agccccggta      180

ccctgtccct gagccccggg gagagagcca ccctgagctg ccgggccagc cagagcgtgg      240

gctctagcta tctggcctgg taccagcaga aacctggcca ggcccccaga ctgctgatct      300

atggcgcctt tagcagagcc accggcattc ccgacagatt cagcggaagc ggcagcggca      360

ccgacttcac cctgacgatc agcagactgg aacccgagga tttcgccgtg tactactgcc      420

agcagtacgg cagcagcccc tggaccttcg ggcagggcac caaggtggag attaagagaa      480

ccgtggccgc ccccagcgtg ttcatctttc ccccctctga cgagcagctg aagagcggca      540

ccgccagcgt ggtgtgcctc ctgaacaact tctacccccg ggaggctaag gtgcagtgga      600

aggtggacaa cgccctgcag agcggcaact cacaggagag cgtgacagag caggactcaa      660

aggacagcac ctacagcctg tccagcaccc tgaccctgtc aaaggccgac tacgagaagc      720

acaaggtgta cgcctgcgag gtcacccacc agggactgag ctcacccgtt accaagagct      780

tcaaccgcgg cgagtgctga taataggctg gagcctcggt ggccatgctt cttgcccctt      840

gggcctcccc ccagcccctc ctccccttcc tgcacccgta ccccccaaac accattgtca      900

cactccagtg gtctttgaat aaagtctgag tgggcggc                              938


<210>  272
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  272

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  273
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  273
atggagaccc ccgcccagct gctcttcctg ctgctgctgt ggctgcctga caccaccggc       60

gagatcgtgc tgacccaaag ccccggtacc ctgtccctga gccccgggga gagagccacc      120

ctgagctgcc gggccagcca gagcgtgggc tctagctatc tggcctggta ccagcagaaa      180

cctggccagg cccccagact gctgatctat ggcgccttta gcagagccac cggcattccc      240

gacagattca gcggaagcgg cagcggcacc gacttcaccc tgacgatcag cagactggaa      300

cccgaggatt tcgccgtgta ctactgccag cagtacggca gcagcccctg gaccttcggg      360

cagggcacca aggtggagat taagagaacc gtggccgccc ccagcgtgtt catctttccc      420

ccctctgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctcct gaacaacttc      480

tacccccggg aggctaaggt gcagtggaag gtggacaacg ccctgcagag cggcaactca      540

caggagagcg tgacagagca ggactcaaag gacagcacct acagcctgtc cagcaccctg      600

accctgtcaa aggccgacta cgagaagcac aaggtgtacg cctgcgaggt cacccaccag      660

ggactgagct cacccgttac caagagcttc aaccgcggcg agtgc                      705


<210>  274
<211>  997
<212>  DNA
<213>  Homo sapiens

<400>  274
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccccgc       60

ccagctgctc ttcctgctgc tgctgtggct gcctgacacc accggcgaga tcgtgctgac      120

ccaaagcccc ggtaccctgt ccctgagccc cggggagaga gccaccctga gctgccgggc      180

cagccagagc gtgggctcta gctatctggc ctggtaccag cagaaacctg gccaggcccc      240

cagactgctg atctatggcg cctttagcag agccaccggc attcccgaca gattcagcgg      300

aagcggcagc ggcaccgact tcaccctgac gatcagcaga ctggaacccg aggatttcgc      360

cgtgtactac tgccagcagt acggcagcag cccctggacc ttcgggcagg gcaccaaggt      420

ggagattaag agaaccgtgg ccgcccccag cgtgttcatc tttcccccct ctgacgagca      480

gctgaagagc ggcaccgcca gcgtggtgtg cctcctgaac aacttctacc cccgggaggc      540

taaggtgcag tggaaggtgg acaacgccct gcagagcggc aactcacagg agagcgtgac      600

agagcaggac tcaaaggaca gcacctacag cctgtccagc accctgaccc tgtcaaaggc      660

cgactacgag aagcacaagg tgtacgcctg cgaggtcacc caccagggac tgagctcacc      720

cgttaccaag agcttcaacc gcggcgagtg ctgataatag gctggagcct cggtggccat      780

gcttcttgcc ccttgggcct ccccccagcc cctcctcccc ttcctgcacc cgtacccccc      840

aaacaccatt gtcacactcc agtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatctag                               997


<210>  275
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  275

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  276
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  276
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac acccgcccag ttactgttcc      120

tcctgctgct gtggctgcct gacaccaccg gcgagatcgt gctgacccag agccccggca      180

ccctgagcct gtcccccggc gagagagcca ccctgagctg ccgcgcctca cagagcgtgg      240

gcagctcata cctggcctgg taccagcaga agcccggaca ggctcccaga ctgctgatct      300

acggcgcctt ttccagagcc accggcatcc ccgaccggtt cagcggctct ggaagcggca      360

ccgacttcac cctgaccatc agccggttgg agcccgagga tttcgctgtg tactactgtc      420

agcaatacgg aagcagcccc tggaccttcg gccagggcac caaggtggag atcaagagaa      480

ccgtggccgc ccccagcgtg ttcatctttc cccccagcga cgaacagctg aagagcggca      540

ccgcctcagt ggtctgcctg ctcaataact tctacccccg ggaggccaaa gtgcagtgga      600

aggtggacaa cgccctgcag agcggcaaca gccaggagag cgtgaccgag caggacagca      660

aagactcaac atacagcctg agcagtaccc tgactctgag caaggccgac tacgagaagc      720

ataaggtgta tgcctgcgag gtgacccacc agggcctgag cagccccgtg accaagtcat      780

tcaaccgagg cgagtgctga taataggctg gagcctcggt ggccatgctt cttgcccctt      840

gggcctcccc ccagcccctc ctccccttcc tgcacccgta ccccccaaac accattgtca      900

cactccagtg gtctttgaat aaagtctgag tgggcggc                              938


<210>  277
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  277

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  278
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  278
atggagacac ccgcccagtt actgttcctc ctgctgctgt ggctgcctga caccaccggc       60

gagatcgtgc tgacccagag ccccggcacc ctgagcctgt cccccggcga gagagccacc      120

ctgagctgcc gcgcctcaca gagcgtgggc agctcatacc tggcctggta ccagcagaag      180

cccggacagg ctcccagact gctgatctac ggcgcctttt ccagagccac cggcatcccc      240

gaccggttca gcggctctgg aagcggcacc gacttcaccc tgaccatcag ccggttggag      300

cccgaggatt tcgctgtgta ctactgtcag caatacggaa gcagcccctg gaccttcggc      360

cagggcacca aggtggagat caagagaacc gtggccgccc ccagcgtgtt catctttccc      420

cccagcgacg aacagctgaa gagcggcacc gcctcagtgg tctgcctgct caataacttc      480

tacccccggg aggccaaagt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      540

caggagagcg tgaccgagca ggacagcaaa gactcaacat acagcctgag cagtaccctg      600

actctgagca aggccgacta cgagaagcat aaggtgtatg cctgcgaggt gacccaccag      660

ggcctgagca gccccgtgac caagtcattc aaccgaggcg agtgc                      705


<210>  279
<211>  997
<212>  DNA
<213>  Homo sapiens

<400>  279
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacacccgc       60

ccagttactg ttcctcctgc tgctgtggct gcctgacacc accggcgaga tcgtgctgac      120

ccagagcccc ggcaccctga gcctgtcccc cggcgagaga gccaccctga gctgccgcgc      180

ctcacagagc gtgggcagct catacctggc ctggtaccag cagaagcccg gacaggctcc      240

cagactgctg atctacggcg ccttttccag agccaccggc atccccgacc ggttcagcgg      300

ctctggaagc ggcaccgact tcaccctgac catcagccgg ttggagcccg aggatttcgc      360

tgtgtactac tgtcagcaat acggaagcag cccctggacc ttcggccagg gcaccaaggt      420

ggagatcaag agaaccgtgg ccgcccccag cgtgttcatc tttcccccca gcgacgaaca      480

gctgaagagc ggcaccgcct cagtggtctg cctgctcaat aacttctacc cccgggaggc      540

caaagtgcag tggaaggtgg acaacgccct gcagagcggc aacagccagg agagcgtgac      600

cgagcaggac agcaaagact caacatacag cctgagcagt accctgactc tgagcaaggc      660

cgactacgag aagcataagg tgtatgcctg cgaggtgacc caccagggcc tgagcagccc      720

cgtgaccaag tcattcaacc gaggcgagtg ctgataatag gctggagcct cggtggccat      780

gcttcttgcc ccttgggcct ccccccagcc cctcctcccc ttcctgcacc cgtacccccc      840

aaacaccatt gtcacactcc agtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatctag                               997


<210>  280
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  280

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  281
<211>  1658
<212>  DNA
<213>  Homo sapiens

<400>  281
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac gcccgctcag ctgctgttcc      120

tgctgctgct gtggctgccc gatacaactg ggcaggtgca gttggtggaa agcggcggcg      180

gagtggtgca gccaggacgg agcctgagac tgagctgcgc cgcctccggc ttcactttct      240

ccagctatgg catgcattgg gtgcggcagg cacccggcaa gggcctggag tgggtggccg      300

tcatctggta cgacggcagc aataagtact acgccgactc cgtgaagggc aggttcacca      360

tctccaggga taacagcaag aatacactgt acctgcagat gaatagcctg agggctgagg      420

acaccgccgt gtactactgt gcccgggacc ccaggggcgc caccctgtac tactactact      480

acggaatgga cgtgtggggc cagggcacca cagtcacagt ctctagcgcc tccaccaagg      540

gccctagcgt gttccctctg gcccccagca gcaagtctac cagcggcggc accgccgccc      600

tgggctgcct ggtgaaggac tactttcccg agcccgtgac cgtcagctgg aacagcggcg      660

ccctgaccag cggcgtccac accttccccg ccgtgctgca gagcagcggc ctgtacagtc      720

tgagctccgt ggtgacagtt ccctcaagca gcctgggcac acagacctat atctgcaacg      780

tgaaccacaa gcccagcaac acaaaggtgg acaagagagt ggagcccaag agctgcgaca      840

agacccacac ctgtcccccc tgccccgccc cggagctgct gggggggccc agcgtgttcc      900

tgttcccccc caaacccaag gacaccctga tgattagcag gactccagaa gtcacctgcg      960

tggtggtgga cgtgtcgcac gaggaccccg aggtgaagtt caactggtat gtggacggcg     1020

tggaggtaca caatgccaag accaagccta gggaggagca gtacaactcc acctacagag     1080

tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag tacaagtgca     1140

aagtgagcaa taaggcactg cccgctccca tcgagaagac catcagcaag gcaaaggggc     1200

agccccgcga gccccaggtg tacaccctgc ccccctccag ggaagagatg actaaaaatc     1260

aggtgagcct gacatgcctg gtgaagggct tctacccaag cgatatcgcc gtggagtggg     1320

agagcaacgg ccaacccgaa aacaactaca aaacgacccc accggtcctg gattcggatg     1380

gcagcttctt cctgtatagc aagctgacag tggacaagtc cagatggcag cagggaaacg     1440

tgttcagctg cagcgtcatg cacgaggccc tgcacaacca ctacacccag aagagcctca     1500

gcctgtcccc cggcaagtga taataggctg gagcctcggt ggccatgctt cttgcccctt     1560

gggcctcccc ccagcccctc ctccccttcc tgcacccgta ccccccaaac accattgtca     1620

cactccagtg gtctttgaat aaagtctgag tgggcggc                             1658


<210>  282
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  283
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  283
atggagacgc ccgctcagct gctgttcctg ctgctgctgt ggctgcccga tacaactggg       60

caggtgcagt tggtggaaag cggcggcgga gtggtgcagc caggacggag cctgagactg      120

agctgcgccg cctccggctt cactttctcc agctatggca tgcattgggt gcggcaggca      180

cccggcaagg gcctggagtg ggtggccgtc atctggtacg acggcagcaa taagtactac      240

gccgactccg tgaagggcag gttcaccatc tccagggata acagcaagaa tacactgtac      300

ctgcagatga atagcctgag ggctgaggac accgccgtgt actactgtgc ccgggacccc      360

aggggcgcca ccctgtacta ctactactac ggaatggacg tgtggggcca gggcaccaca      420

gtcacagtct ctagcgcctc caccaagggc cctagcgtgt tccctctggc ccccagcagc      480

aagtctacca gcggcggcac cgccgccctg ggctgcctgg tgaaggacta ctttcccgag      540

cccgtgaccg tcagctggaa cagcggcgcc ctgaccagcg gcgtccacac cttccccgcc      600

gtgctgcaga gcagcggcct gtacagtctg agctccgtgg tgacagttcc ctcaagcagc      660

ctgggcacac agacctatat ctgcaacgtg aaccacaagc ccagcaacac aaaggtggac      720

aagagagtgg agcccaagag ctgcgacaag acccacacct gtcccccctg ccccgccccg      780

gagctgctgg gggggcccag cgtgttcctg ttccccccca aacccaagga caccctgatg      840

attagcagga ctccagaagt cacctgcgtg gtggtggacg tgtcgcacga ggaccccgag      900

gtgaagttca actggtatgt ggacggcgtg gaggtacaca atgccaagac caagcctagg      960

gaggagcagt acaactccac ctacagagtg gtgagcgtgc tgaccgtgct gcaccaggac     1020

tggctgaacg gcaaggagta caagtgcaaa gtgagcaata aggcactgcc cgctcccatc     1080

gagaagacca tcagcaaggc aaaggggcag ccccgcgagc cccaggtgta caccctgccc     1140

ccctccaggg aagagatgac taaaaatcag gtgagcctga catgcctggt gaagggcttc     1200

tacccaagcg atatcgccgt ggagtgggag agcaacggcc aacccgaaaa caactacaaa     1260

acgaccccac cggtcctgga ttcggatggc agcttcttcc tgtatagcaa gctgacagtg     1320

gacaagtcca gatggcagca gggaaacgtg ttcagctgca gcgtcatgca cgaggccctg     1380

cacaaccact acacccagaa gagcctcagc ctgtcccccg gcaag                     1425


<210>  284
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  284
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacgcccgc       60

tcagctgctg ttcctgctgc tgctgtggct gcccgataca actgggcagg tgcagttggt      120

ggaaagcggc ggcggagtgg tgcagccagg acggagcctg agactgagct gcgccgcctc      180

cggcttcact ttctccagct atggcatgca ttgggtgcgg caggcacccg gcaagggcct      240

ggagtgggtg gccgtcatct ggtacgacgg cagcaataag tactacgccg actccgtgaa      300

gggcaggttc accatctcca gggataacag caagaataca ctgtacctgc agatgaatag      360

cctgagggct gaggacaccg ccgtgtacta ctgtgcccgg gaccccaggg gcgccaccct      420

gtactactac tactacggaa tggacgtgtg gggccagggc accacagtca cagtctctag      480

cgcctccacc aagggcccta gcgtgttccc tctggccccc agcagcaagt ctaccagcgg      540

cggcaccgcc gccctgggct gcctggtgaa ggactacttt cccgagcccg tgaccgtcag      600

ctggaacagc ggcgccctga ccagcggcgt ccacaccttc cccgccgtgc tgcagagcag      660

cggcctgtac agtctgagct ccgtggtgac agttccctca agcagcctgg gcacacagac      720

ctatatctgc aacgtgaacc acaagcccag caacacaaag gtggacaaga gagtggagcc      780

caagagctgc gacaagaccc acacctgtcc cccctgcccc gccccggagc tgctgggggg      840

gcccagcgtg ttcctgttcc cccccaaacc caaggacacc ctgatgatta gcaggactcc      900

agaagtcacc tgcgtggtgg tggacgtgtc gcacgaggac cccgaggtga agttcaactg      960

gtatgtggac ggcgtggagg tacacaatgc caagaccaag cctagggagg agcagtacaa     1020

ctccacctac agagtggtga gcgtgctgac cgtgctgcac caggactggc tgaacggcaa     1080

ggagtacaag tgcaaagtga gcaataaggc actgcccgct cccatcgaga agaccatcag     1140

caaggcaaag gggcagcccc gcgagcccca ggtgtacacc ctgcccccct ccagggaaga     1200

gatgactaaa aatcaggtga gcctgacatg cctggtgaag ggcttctacc caagcgatat     1260

cgccgtggag tgggagagca acggccaacc cgaaaacaac tacaaaacga ccccaccggt     1320

cctggattcg gatggcagct tcttcctgta tagcaagctg acagtggaca agtccagatg     1380

gcagcaggga aacgtgttca gctgcagcgt catgcacgag gccctgcaca accactacac     1440

ccagaagagc ctcagcctgt cccccggcaa gtgataatag gctggagcct cggtggccat     1500

gcttcttgcc ccttgggcct ccccccagcc cctcctcccc ttcctgcacc cgtacccccc     1560

aaacaccatt gtcacactcc agtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatctag                              1717


<210>  285
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  285

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  286
<211>  1658
<212>  DNA
<213>  Homo sapiens

<400>  286
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggaaac cccagcccag ctcctgttcc      120

tgctgctgct gtggctgccc gacaccaccg gccaggtgca gctggtggag tcaggcggcg      180

gcgtggtgca accaggccgc agcctgaggc tcagctgcgc cgcctccggc ttcaccttca      240

gttcctacgg catgcactgg gtgagacagg cccccggcaa gggcctggag tgggtggccg      300

tgatctggta cgacggcagc aacaaatact atgctgacag cgtgaagggc cggttcacca      360

tctccaggga caatagcaaa aacaccctgt acctgcaaat gaatagcctg agggccgagg      420

acaccgctgt gtactactgc gccagggacc ctaggggcgc caccctttac tactactact      480

acggcatgga cgtgtggggc cagggcacta ccgtcaccgt gtccagcgcc agcaccaagg      540

gccccagcgt gttcccactg gcacccagct ctaagagcac cagcggcggc accgccgccc      600

tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg aacagcggcg      660

ccctgacttc cggcgtccac acattccccg ccgtgctgca gagcagcggg ctgtacagcc      720

tgtcatccgt ggtgaccgtg cctagcagca gtctgggcac tcagacctat atttgcaacg      780

tgaaccacaa gccctccaac accaaagtgg ataagagagt ggagcctaag agctgtgata      840

agacccacac ctgccctcct tgcccagctc cggagctgct gggcggcccc agcgtgttcc      900

tgttcccccc gaagcccaag gacacactga tgatcagcag aacccccgaa gttacttgcg      960

tggtggtgga cgtcagccac gaagaccccg aggtcaagtt caattggtat gtggacggcg     1020

tggaggtgca caacgccaag acaaagccga gagaggagca gtacaattcc acctatagag     1080

tggtgagcgt gctgacagtc ctccaccagg actggctgaa cggcaaggag tacaagtgca     1140

aggtcagcaa caaagccctg cctgctccca tcgagaagac catctccaag gctaaaggcc     1200

agcctagaga gccccaggtg tacaccctgc ccccctccag agaggagatg accaagaacc     1260

aggtgagcct gacatgcctg gtgaagggct tctaccccag cgacatcgct gtggagtggg     1320

agagcaatgg ccagcccgag aataactaca agaccacccc ccccgtgctc gacagcgacg     1380

gcagcttctt cctgtacagc aagctgaccg tggataagag cagatggcaa cagggtaatg     1440

tgtttagctg ctccgtgatg cacgaggccc tccacaacca ttacacccag aaaagcctgt     1500

ccctgagccc cggcaagtga taataggctg gagcctcggt ggccatgctt cttgcccctt     1560

gggcctcccc ccagcccctc ctccccttcc tgcacccgta ccccccaaac accattgtca     1620

cactccagtg gtctttgaat aaagtctgag tgggcggc                             1658


<210>  287
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  287

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  288
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  288
atggaaaccc cagcccagct cctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

caggtgcagc tggtggagtc aggcggcggc gtggtgcaac caggccgcag cctgaggctc      120

agctgcgccg cctccggctt caccttcagt tcctacggca tgcactgggt gagacaggcc      180

cccggcaagg gcctggagtg ggtggccgtg atctggtacg acggcagcaa caaatactat      240

gctgacagcg tgaagggccg gttcaccatc tccagggaca atagcaaaaa caccctgtac      300

ctgcaaatga atagcctgag ggccgaggac accgctgtgt actactgcgc cagggaccct      360

aggggcgcca ccctttacta ctactactac ggcatggacg tgtggggcca gggcactacc      420

gtcaccgtgt ccagcgccag caccaagggc cccagcgtgt tcccactggc acccagctct      480

aagagcacca gcggcggcac cgccgccctg ggctgcctgg tgaaggacta cttccccgag      540

cccgtgaccg tgagctggaa cagcggcgcc ctgacttccg gcgtccacac attccccgcc      600

gtgctgcaga gcagcgggct gtacagcctg tcatccgtgg tgaccgtgcc tagcagcagt      660

ctgggcactc agacctatat ttgcaacgtg aaccacaagc cctccaacac caaagtggat      720

aagagagtgg agcctaagag ctgtgataag acccacacct gccctccttg cccagctccg      780

gagctgctgg gcggccccag cgtgttcctg ttccccccga agcccaagga cacactgatg      840

atcagcagaa cccccgaagt tacttgcgtg gtggtggacg tcagccacga agaccccgag      900

gtcaagttca attggtatgt ggacggcgtg gaggtgcaca acgccaagac aaagccgaga      960

gaggagcagt acaattccac ctatagagtg gtgagcgtgc tgacagtcct ccaccaggac     1020

tggctgaacg gcaaggagta caagtgcaag gtcagcaaca aagccctgcc tgctcccatc     1080

gagaagacca tctccaaggc taaaggccag cctagagagc cccaggtgta caccctgccc     1140

ccctccagag aggagatgac caagaaccag gtgagcctga catgcctggt gaagggcttc     1200

taccccagcg acatcgctgt ggagtgggag agcaatggcc agcccgagaa taactacaag     1260

accacccccc ccgtgctcga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg     1320

gataagagca gatggcaaca gggtaatgtg tttagctgct ccgtgatgca cgaggccctc     1380

cacaaccatt acacccagaa aagcctgtcc ctgagccccg gcaag                     1425


<210>  289
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  289
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg aaaccccagc       60

ccagctcctg ttcctgctgc tgctgtggct gcccgacacc accggccagg tgcagctggt      120

ggagtcaggc ggcggcgtgg tgcaaccagg ccgcagcctg aggctcagct gcgccgcctc      180

cggcttcacc ttcagttcct acggcatgca ctgggtgaga caggcccccg gcaagggcct      240

ggagtgggtg gccgtgatct ggtacgacgg cagcaacaaa tactatgctg acagcgtgaa      300

gggccggttc accatctcca gggacaatag caaaaacacc ctgtacctgc aaatgaatag      360

cctgagggcc gaggacaccg ctgtgtacta ctgcgccagg gaccctaggg gcgccaccct      420

ttactactac tactacggca tggacgtgtg gggccagggc actaccgtca ccgtgtccag      480

cgccagcacc aagggcccca gcgtgttccc actggcaccc agctctaaga gcaccagcgg      540

cggcaccgcc gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgag      600

ctggaacagc ggcgccctga cttccggcgt ccacacattc cccgccgtgc tgcagagcag      660

cgggctgtac agcctgtcat ccgtggtgac cgtgcctagc agcagtctgg gcactcagac      720

ctatatttgc aacgtgaacc acaagccctc caacaccaaa gtggataaga gagtggagcc      780

taagagctgt gataagaccc acacctgccc tccttgccca gctccggagc tgctgggcgg      840

ccccagcgtg ttcctgttcc ccccgaagcc caaggacaca ctgatgatca gcagaacccc      900

cgaagttact tgcgtggtgg tggacgtcag ccacgaagac cccgaggtca agttcaattg      960

gtatgtggac ggcgtggagg tgcacaacgc caagacaaag ccgagagagg agcagtacaa     1020

ttccacctat agagtggtga gcgtgctgac agtcctccac caggactggc tgaacggcaa     1080

ggagtacaag tgcaaggtca gcaacaaagc cctgcctgct cccatcgaga agaccatctc     1140

caaggctaaa ggccagccta gagagcccca ggtgtacacc ctgcccccct ccagagagga     1200

gatgaccaag aaccaggtga gcctgacatg cctggtgaag ggcttctacc ccagcgacat     1260

cgctgtggag tgggagagca atggccagcc cgagaataac tacaagacca ccccccccgt     1320

gctcgacagc gacggcagct tcttcctgta cagcaagctg accgtggata agagcagatg     1380

gcaacagggt aatgtgttta gctgctccgt gatgcacgag gccctccaca accattacac     1440

ccagaaaagc ctgtccctga gccccggcaa gtgataatag gctggagcct cggtggccat     1500

gcttcttgcc ccttgggcct ccccccagcc cctcctcccc ttcctgcacc cgtacccccc     1560

aaacaccatt gtcacactcc agtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatctag                              1717


<210>  290
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  290

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  291
<211>  1658
<212>  DNA
<213>  Homo sapiens

<400>  291
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggaaac ccccgctcag ctgctgtttc      120

tgcttctgct gtggctccct gacactaccg gacaggtgca gctcgtggag agcggcggcg      180

gcgtggtgca gcccggcagg agcctgagac tgagctgcgc cgcctctggc ttcacattca      240

gcagctacgg catgcactgg gtgcggcagg cccccggcaa gggactggag tgggtggccg      300

tgatctggta cgacggatca aacaagtact acgccgactc ggtgaagggc aggttcacca      360

tcagccgcga caacagcaag aacaccctgt acctgcagat gaacagcctg agagccgagg      420

acaccgcggt gtactactgc gcccgggatc ccaggggcgc caccctgtac tactactact      480

acggcatgga cgtgtggggc cagggcacca cagtgacagt gagcagcgcc agcaccaagg      540

gccctagcgt gtttcctctg gccccaagct caaagagcac cagtggcgga accgccgccc      600

tgggctgcct ggtgaaggac tactttcccg agcccgtgac cgtgtcctgg aacagcggcg      660

ccctgacaag cggagtgcac accttcccag cggttctgca gtcatcaggg ctgtacagcc      720

tgagctccgt ggtgaccgtg cccagctcca gcctgggtac ccagacctac atctgcaatg      780

tgaaccacaa gcccagcaac accaaggtgg acaagcgcgt cgagcctaaa agctgcgaca      840

agacccacac ctgccccccc tgccccgccc ccgagctgct ggggggcccc agcgtcttcc      900

tattcccccc taagcccaag gacaccctca tgatcagcag aacccccgag gtgacctgcg      960

tggtggtgga cgtgagccat gaggaccccg aggtgaagtt caattggtac gtggacgggg     1020

tggaagtgca taacgccaag accaagccaa gagaggagca gtacaacagc acctaccgcg     1080

tggtgtccgt gctgaccgtg ttgcatcagg attggcttaa cggcaaggag tataagtgta     1140

aagtgtctaa caaggctctc cccgccccca ttgagaagac catctccaag gccaagggcc     1200

agcccagaga gccccaggtg tatacactgc cccccagcag agaggagatg accaagaacc     1260

aggtgagcct gacctgtctg gtgaagggct tctaccctag cgacattgcc gtggagtggg     1320

agtccaacgg ccagcccgaa aataactaca agaccactcc tcccgtgctt gacagcgacg     1380

ggagcttctt cctgtacagc aagctgaccg tggacaagag caggtggcag cagggcaacg     1440

tgttctcttg cagcgtgatg cacgaggcgc tccacaatca ctacacccag aagagcctgt     1500

ccctgtctcc cggcaagtga taataggctg gagcctcggt ggccatgctt cttgcccctt     1560

gggcctcccc ccagcccctc ctccccttcc tgcacccgta ccccccaaac accattgtca     1620

cactccagtg gtctttgaat aaagtctgag tgggcggc                             1658


<210>  292
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    370                 375                 380                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  293
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  293
atggaaaccc ccgctcagct gctgtttctg cttctgctgt ggctccctga cactaccgga       60

caggtgcagc tcgtggagag cggcggcggc gtggtgcagc ccggcaggag cctgagactg      120

agctgcgccg cctctggctt cacattcagc agctacggca tgcactgggt gcggcaggcc      180

cccggcaagg gactggagtg ggtggccgtg atctggtacg acggatcaaa caagtactac      240

gccgactcgg tgaagggcag gttcaccatc agccgcgaca acagcaagaa caccctgtac      300

ctgcagatga acagcctgag agccgaggac accgcggtgt actactgcgc ccgggatccc      360

aggggcgcca ccctgtacta ctactactac ggcatggacg tgtggggcca gggcaccaca      420

gtgacagtga gcagcgccag caccaagggc cctagcgtgt ttcctctggc cccaagctca      480

aagagcacca gtggcggaac cgccgccctg ggctgcctgg tgaaggacta ctttcccgag      540

cccgtgaccg tgtcctggaa cagcggcgcc ctgacaagcg gagtgcacac cttcccagcg      600

gttctgcagt catcagggct gtacagcctg agctccgtgg tgaccgtgcc cagctccagc      660

ctgggtaccc agacctacat ctgcaatgtg aaccacaagc ccagcaacac caaggtggac      720

aagcgcgtcg agcctaaaag ctgcgacaag acccacacct gccccccctg ccccgccccc      780

gagctgctgg ggggccccag cgtcttccta ttccccccta agcccaagga caccctcatg      840

atcagcagaa cccccgaggt gacctgcgtg gtggtggacg tgagccatga ggaccccgag      900

gtgaagttca attggtacgt ggacggggtg gaagtgcata acgccaagac caagccaaga      960

gaggagcagt acaacagcac ctaccgcgtg gtgtccgtgc tgaccgtgtt gcatcaggat     1020

tggcttaacg gcaaggagta taagtgtaaa gtgtctaaca aggctctccc cgcccccatt     1080

gagaagacca tctccaaggc caagggccag cccagagagc cccaggtgta tacactgccc     1140

cccagcagag aggagatgac caagaaccag gtgagcctga cctgtctggt gaagggcttc     1200

taccctagcg acattgccgt ggagtgggag tccaacggcc agcccgaaaa taactacaag     1260

accactcctc ccgtgcttga cagcgacggg agcttcttcc tgtacagcaa gctgaccgtg     1320

gacaagagca ggtggcagca gggcaacgtg ttctcttgca gcgtgatgca cgaggcgctc     1380

cacaatcact acacccagaa gagcctgtcc ctgtctcccg gcaag                     1425


<210>  294
<211>  1717
<212>  DNA
<213>  Homo sapiens

<400>  294
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg aaacccccgc       60

tcagctgctg tttctgcttc tgctgtggct ccctgacact accggacagg tgcagctcgt      120

ggagagcggc ggcggcgtgg tgcagcccgg caggagcctg agactgagct gcgccgcctc      180

tggcttcaca ttcagcagct acggcatgca ctgggtgcgg caggcccccg gcaagggact      240

ggagtgggtg gccgtgatct ggtacgacgg atcaaacaag tactacgccg actcggtgaa      300

gggcaggttc accatcagcc gcgacaacag caagaacacc ctgtacctgc agatgaacag      360

cctgagagcc gaggacaccg cggtgtacta ctgcgcccgg gatcccaggg gcgccaccct      420

gtactactac tactacggca tggacgtgtg gggccagggc accacagtga cagtgagcag      480

cgccagcacc aagggcccta gcgtgtttcc tctggcccca agctcaaaga gcaccagtgg      540

cggaaccgcc gccctgggct gcctggtgaa ggactacttt cccgagcccg tgaccgtgtc      600

ctggaacagc ggcgccctga caagcggagt gcacaccttc ccagcggttc tgcagtcatc      660

agggctgtac agcctgagct ccgtggtgac cgtgcccagc tccagcctgg gtacccagac      720

ctacatctgc aatgtgaacc acaagcccag caacaccaag gtggacaagc gcgtcgagcc      780

taaaagctgc gacaagaccc acacctgccc cccctgcccc gcccccgagc tgctgggggg      840

ccccagcgtc ttcctattcc cccctaagcc caaggacacc ctcatgatca gcagaacccc      900

cgaggtgacc tgcgtggtgg tggacgtgag ccatgaggac cccgaggtga agttcaattg      960

gtacgtggac ggggtggaag tgcataacgc caagaccaag ccaagagagg agcagtacaa     1020

cagcacctac cgcgtggtgt ccgtgctgac cgtgttgcat caggattggc ttaacggcaa     1080

ggagtataag tgtaaagtgt ctaacaaggc tctccccgcc cccattgaga agaccatctc     1140

caaggccaag ggccagccca gagagcccca ggtgtataca ctgcccccca gcagagagga     1200

gatgaccaag aaccaggtga gcctgacctg tctggtgaag ggcttctacc ctagcgacat     1260

tgccgtggag tgggagtcca acggccagcc cgaaaataac tacaagacca ctcctcccgt     1320

gcttgacagc gacgggagct tcttcctgta cagcaagctg accgtggaca agagcaggtg     1380

gcagcagggc aacgtgttct cttgcagcgt gatgcacgag gcgctccaca atcactacac     1440

ccagaagagc ctgtccctgt ctcccggcaa gtgataatag gctggagcct cggtggccat     1500

gcttcttgcc ccttgggcct ccccccagcc cctcctcccc ttcctgcacc cgtacccccc     1560

aaacaccatt gtcacactcc agtggtcttt gaataaagtc tgagtgggcg gcaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aatctag                              1717


<210>  295
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  295

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    290                 295                 300                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly Lys 
    450                 455 


<210>  296
<211>  1646
<212>  DNA
<213>  Homo sapiens

<400>  296
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccccgcccag ctgctgttcc      120

tgctgctgct gtggctgccc gataccaccg gccaggtcca gctcgtggag agcggcggcg      180

gcgtggttca gcccggcaga agcctgagac tgagctgcgc cgccagcggc ttcaccttct      240

caagctacgg catgcactgg gtgagacagg ccccgggcaa gggcctcgaa tgggtggccg      300

tgatctggta cgacggaagc aacaagtact acgccgatag tgtgaagggc aggttcacta      360

tcagccgaga taacagcaaa aacaccctgt atctgcagat gaactcactg cgtgccgagg      420

ataccgctgt gtactattgc gccagggacc ctagaggagc cacgctgtac tactactact      480

acggcatgga cgtttggggc cagggaacca ccgtcaccgt gagcagcgcc tccaccaaag      540

gccccagcgt gttccccctg gccccttgct ccaggagtac cagcgagagc accgccgccc      600

tgggctgcct ggtgaaggac tatttccccg agcccgtgac cgtgtcctgg aactctggcg      660

ccctgaccag cggggtgcac accttccccg ccgtcctgca gagtagcgga ctgtacagcc      720

tgagcagcgt agtgactgtg ccctccagca acttcggcac tcagacctat acttgtaacg      780

tcgaccacaa gccttccaac acaaaggtgg acaaaaccgt ggagaggaag tgttgcgttg      840

agtgcccccc ctgtccggcc ccgcccgtgg cggggcctag cgtgttcctc ttccctccca      900

agccaaagga caccctgatg atcagcagga cccccgaggt gacctgcgtg gtggtggatg      960

tgagccatga ggaccccgag gtgcagttta actggtacgt ggacggagtg gaggtgcata     1020

acgccaagac caagcctagg gaggagcagt tcaacagcac cttcagagtg gttagcgtgc     1080

tgaccgtggt gcaccaggat tggctgaacg ggaaggagta caagtgcaag gtgagcaaca     1140

agggcctgcc cgccccaatc gagaagacca tctcaaagac caaggggcag cctagagagc     1200

cccaggtgta caccctgccc cctagcagag aggagatgac caagaaccag gtgagcctca     1260

cctgcctcgt gaagggcttc taccccagcg acatcgctgt ggagtgggag tccaacggcc     1320

agcccgagaa caactacaaa accacacccc caatgctgga ctccgacggc agcttcttcc     1380

tgtacagcaa gctgacagtg gacaaaagca gatggcagca gggcaacgtg ttcagctgct     1440

ctgtgatgca cgaggccctg cacaatcatt atactcagaa gagcctgagc ctgtcccccg     1500

gaaagtgata ataggctgga gcctcggtgg ccatgcttct tgccccttgg gcctcccccc     1560

agcccctcct ccccttcctg cacccgtacc ccccaaacac cattgtcaca ctccagtggt     1620

ctttgaataa agtctgagtg ggcggc                                          1646


<210>  297
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  297

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  298
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  298
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga taccaccggc       60

caggtccagc tcgtggagag cggcggcggc gtggttcagc ccggcagaag cctgagactg      120

agctgcgccg ccagcggctt caccttctca agctacggca tgcactgggt gagacaggcc      180

ccgggcaagg gcctcgaatg ggtggccgtg atctggtacg acggaagcaa caagtactac      240

gccgatagtg tgaagggcag gttcactatc agccgagata acagcaaaaa caccctgtat      300

ctgcagatga actcactgcg tgccgaggat accgctgtgt actattgcgc cagggaccct      360

agaggagcca cgctgtacta ctactactac ggcatggacg tttggggcca gggaaccacc      420

gtcaccgtga gcagcgcctc caccaaaggc cccagcgtgt tccccctggc cccttgctcc      480

aggagtacca gcgagagcac cgccgccctg ggctgcctgg tgaaggacta tttccccgag      540

cccgtgaccg tgtcctggaa ctctggcgcc ctgaccagcg gggtgcacac cttccccgcc      600

gtcctgcaga gtagcggact gtacagcctg agcagcgtag tgactgtgcc ctccagcaac      660

ttcggcactc agacctatac ttgtaacgtc gaccacaagc cttccaacac aaaggtggac      720

aaaaccgtgg agaggaagtg ttgcgttgag tgccccccct gtccggcccc gcccgtggcg      780

gggcctagcg tgttcctctt ccctcccaag ccaaaggaca ccctgatgat cagcaggacc      840

cccgaggtga cctgcgtggt ggtggatgtg agccatgagg accccgaggt gcagtttaac      900

tggtacgtgg acggagtgga ggtgcataac gccaagacca agcctaggga ggagcagttc      960

aacagcacct tcagagtggt tagcgtgctg accgtggtgc accaggattg gctgaacggg     1020

aaggagtaca agtgcaaggt gagcaacaag ggcctgcccg ccccaatcga gaagaccatc     1080

tcaaagacca aggggcagcc tagagagccc caggtgtaca ccctgccccc tagcagagag     1140

gagatgacca agaaccaggt gagcctcacc tgcctcgtga agggcttcta ccccagcgac     1200

atcgctgtgg agtgggagtc caacggccag cccgagaaca actacaaaac cacaccccca     1260

atgctggact ccgacggcag cttcttcctg tacagcaagc tgacagtgga caaaagcaga     1320

tggcagcagg gcaacgtgtt cagctgctct gtgatgcacg aggccctgca caatcattat     1380

actcagaaga gcctgagcct gtcccccgga aag                                  1413


<210>  299
<211>  1705
<212>  DNA
<213>  Homo sapiens

<400>  299
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccccgc       60

ccagctgctg ttcctgctgc tgctgtggct gcccgatacc accggccagg tccagctcgt      120

ggagagcggc ggcggcgtgg ttcagcccgg cagaagcctg agactgagct gcgccgccag      180

cggcttcacc ttctcaagct acggcatgca ctgggtgaga caggccccgg gcaagggcct      240

cgaatgggtg gccgtgatct ggtacgacgg aagcaacaag tactacgccg atagtgtgaa      300

gggcaggttc actatcagcc gagataacag caaaaacacc ctgtatctgc agatgaactc      360

actgcgtgcc gaggataccg ctgtgtacta ttgcgccagg gaccctagag gagccacgct      420

gtactactac tactacggca tggacgtttg gggccaggga accaccgtca ccgtgagcag      480

cgcctccacc aaaggcccca gcgtgttccc cctggcccct tgctccagga gtaccagcga      540

gagcaccgcc gccctgggct gcctggtgaa ggactatttc cccgagcccg tgaccgtgtc      600

ctggaactct ggcgccctga ccagcggggt gcacaccttc cccgccgtcc tgcagagtag      660

cggactgtac agcctgagca gcgtagtgac tgtgccctcc agcaacttcg gcactcagac      720

ctatacttgt aacgtcgacc acaagccttc caacacaaag gtggacaaaa ccgtggagag      780

gaagtgttgc gttgagtgcc ccccctgtcc ggccccgccc gtggcggggc ctagcgtgtt      840

cctcttccct cccaagccaa aggacaccct gatgatcagc aggacccccg aggtgacctg      900

cgtggtggtg gatgtgagcc atgaggaccc cgaggtgcag tttaactggt acgtggacgg      960

agtggaggtg cataacgcca agaccaagcc tagggaggag cagttcaaca gcaccttcag     1020

agtggttagc gtgctgaccg tggtgcacca ggattggctg aacgggaagg agtacaagtg     1080

caaggtgagc aacaagggcc tgcccgcccc aatcgagaag accatctcaa agaccaaggg     1140

gcagcctaga gagccccagg tgtacaccct gccccctagc agagaggaga tgaccaagaa     1200

ccaggtgagc ctcacctgcc tcgtgaaggg cttctacccc agcgacatcg ctgtggagtg     1260

ggagtccaac ggccagcccg agaacaacta caaaaccaca cccccaatgc tggactccga     1320

cggcagcttc ttcctgtaca gcaagctgac agtggacaaa agcagatggc agcagggcaa     1380

cgtgttcagc tgctctgtga tgcacgaggc cctgcacaat cattatactc agaagagcct     1440

gagcctgtcc cccggaaagt gataataggc tggagcctcg gtggccatgc ttcttgcccc     1500

ttgggcctcc ccccagcccc tcctcccctt cctgcacccg taccccccaa acaccattgt     1560

cacactccag tggtctttga ataaagtctg agtgggcggc aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa tctag                                           1705


<210>  300
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  300

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  301
<211>  1646
<212>  DNA
<213>  Homo sapiens

<400>  301
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac cccagcccag ctgctgttcc      120

tgcttctgct gtggctgcca gataccaccg gccaggtgca gctggttgag tcaggcggcg      180

gcgtggtgca gcccggcaga agcctgcggc tgagctgcgc cgccagcggc ttcaccttca      240

gcagctacgg catgcactgg gtgagacagg cccctggcaa ggggctggag tgggtggccg      300

tgatctggta tgacggaagt aacaagtact acgccgacag cgtgaagggc agattcacga      360

tcagcagaga caactccaag aacacgctgt acttgcagat gaacagcctg agagccgagg      420

acacagccgt gtattactgc gccagagacc ccagaggcgc caccctgtac tactactact      480

acggcatgga cgtgtggggc cagggcacca ccgtgaccgt gagcagtgcc agcaccaagg      540

gccccagcgt gttccccctg gccccctgca gtcggagcac cagcgaaagc accgccgccc      600

tgggctgcct ggtgaaagac tatttccccg agcctgtgac agtgagctgg aacagcgggg      660

ccctcacctc tggcgtgcac acgttcccag ccgtgctgca gagcagcggg ctgtacagcc      720

tgtcctctgt ggtgaccgtg cccagcagca atttcggcac ccagacctac acgtgcaatg      780

tggatcacaa gcccagcaac acaaaagtgg acaaaaccgt ggagagaaag tgttgcgtgg      840

agtgcccccc ttgccccgcc ccccccgtgg ctggcccgtc agtgttcctg ttccctccta      900

agcccaagga caccctcatg atcagcagaa cccccgaggt gacctgcgtg gtcgtggacg      960

tgagtcacga ggaccccgag gtccagttca actggtacgt ggatggagtg gaggtgcaca     1020

acgccaagac caagccccgg gaggagcagt ttaatagcac ctttagggtg gtgagcgtgc     1080

tgaccgttgt acaccaggac tggctgaacg gcaaagagta caaatgcaag gtttcaaata     1140

agggcctgcc cgccccaatt gagaagacaa tcagcaagac taagggccag cctagggaac     1200

cccaggtcta cactctgccc ccctctcggg aggagatgac caagaaccag gtgagcctga     1260

cctgcctggt gaagggcttc tacccttctg acatcgctgt ggagtgggag agcaatggac     1320

aacccgagaa caactacaag accacccccc caatgctgga ctctgatggc agcttctttc     1380

tgtacagcaa gctgacagtg gataaaagca ggtggcagca gggtaatgtg ttcagctgca     1440

gcgtgatgca cgaggcactg cacaatcact acacccagaa gagcctgtcc ctgtcccccg     1500

gcaagtgata ataggctgga gcctcggtgg ccatgcttct tgccccttgg gcctcccccc     1560

agcccctcct ccccttcctg cacccgtacc ccccaaacac cattgtcaca ctccagtggt     1620

ctttgaataa agtctgagtg ggcggc                                          1646


<210>  302
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  302

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  303
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  303
atggagaccc cagcccagct gctgttcctg cttctgctgt ggctgccaga taccaccggc       60

caggtgcagc tggttgagtc aggcggcggc gtggtgcagc ccggcagaag cctgcggctg      120

agctgcgccg ccagcggctt caccttcagc agctacggca tgcactgggt gagacaggcc      180

cctggcaagg ggctggagtg ggtggccgtg atctggtatg acggaagtaa caagtactac      240

gccgacagcg tgaagggcag attcacgatc agcagagaca actccaagaa cacgctgtac      300

ttgcagatga acagcctgag agccgaggac acagccgtgt attactgcgc cagagacccc      360

agaggcgcca ccctgtacta ctactactac ggcatggacg tgtggggcca gggcaccacc      420

gtgaccgtga gcagtgccag caccaagggc cccagcgtgt tccccctggc cccctgcagt      480

cggagcacca gcgaaagcac cgccgccctg ggctgcctgg tgaaagacta tttccccgag      540

cctgtgacag tgagctggaa cagcggggcc ctcacctctg gcgtgcacac gttcccagcc      600

gtgctgcaga gcagcgggct gtacagcctg tcctctgtgg tgaccgtgcc cagcagcaat      660

ttcggcaccc agacctacac gtgcaatgtg gatcacaagc ccagcaacac aaaagtggac      720

aaaaccgtgg agagaaagtg ttgcgtggag tgcccccctt gccccgcccc ccccgtggct      780

ggcccgtcag tgttcctgtt ccctcctaag cccaaggaca ccctcatgat cagcagaacc      840

cccgaggtga cctgcgtggt cgtggacgtg agtcacgagg accccgaggt ccagttcaac      900

tggtacgtgg atggagtgga ggtgcacaac gccaagacca agccccggga ggagcagttt      960

aatagcacct ttagggtggt gagcgtgctg accgttgtac accaggactg gctgaacggc     1020

aaagagtaca aatgcaaggt ttcaaataag ggcctgcccg ccccaattga gaagacaatc     1080

agcaagacta agggccagcc tagggaaccc caggtctaca ctctgccccc ctctcgggag     1140

gagatgacca agaaccaggt gagcctgacc tgcctggtga agggcttcta cccttctgac     1200

atcgctgtgg agtgggagag caatggacaa cccgagaaca actacaagac caccccccca     1260

atgctggact ctgatggcag cttctttctg tacagcaagc tgacagtgga taaaagcagg     1320

tggcagcagg gtaatgtgtt cagctgcagc gtgatgcacg aggcactgca caatcactac     1380

acccagaaga gcctgtccct gtcccccggc aag                                  1413


<210>  304
<211>  1705
<212>  DNA
<213>  Homo sapiens

<400>  304
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agaccccagc       60

ccagctgctg ttcctgcttc tgctgtggct gccagatacc accggccagg tgcagctggt      120

tgagtcaggc ggcggcgtgg tgcagcccgg cagaagcctg cggctgagct gcgccgccag      180

cggcttcacc ttcagcagct acggcatgca ctgggtgaga caggcccctg gcaaggggct      240

ggagtgggtg gccgtgatct ggtatgacgg aagtaacaag tactacgccg acagcgtgaa      300

gggcagattc acgatcagca gagacaactc caagaacacg ctgtacttgc agatgaacag      360

cctgagagcc gaggacacag ccgtgtatta ctgcgccaga gaccccagag gcgccaccct      420

gtactactac tactacggca tggacgtgtg gggccagggc accaccgtga ccgtgagcag      480

tgccagcacc aagggcccca gcgtgttccc cctggccccc tgcagtcgga gcaccagcga      540

aagcaccgcc gccctgggct gcctggtgaa agactatttc cccgagcctg tgacagtgag      600

ctggaacagc ggggccctca cctctggcgt gcacacgttc ccagccgtgc tgcagagcag      660

cgggctgtac agcctgtcct ctgtggtgac cgtgcccagc agcaatttcg gcacccagac      720

ctacacgtgc aatgtggatc acaagcccag caacacaaaa gtggacaaaa ccgtggagag      780

aaagtgttgc gtggagtgcc ccccttgccc cgcccccccc gtggctggcc cgtcagtgtt      840

cctgttccct cctaagccca aggacaccct catgatcagc agaacccccg aggtgacctg      900

cgtggtcgtg gacgtgagtc acgaggaccc cgaggtccag ttcaactggt acgtggatgg      960

agtggaggtg cacaacgcca agaccaagcc ccgggaggag cagtttaata gcacctttag     1020

ggtggtgagc gtgctgaccg ttgtacacca ggactggctg aacggcaaag agtacaaatg     1080

caaggtttca aataagggcc tgcccgcccc aattgagaag acaatcagca agactaaggg     1140

ccagcctagg gaaccccagg tctacactct gcccccctct cgggaggaga tgaccaagaa     1200

ccaggtgagc ctgacctgcc tggtgaaggg cttctaccct tctgacatcg ctgtggagtg     1260

ggagagcaat ggacaacccg agaacaacta caagaccacc cccccaatgc tggactctga     1320

tggcagcttc tttctgtaca gcaagctgac agtggataaa agcaggtggc agcagggtaa     1380

tgtgttcagc tgcagcgtga tgcacgaggc actgcacaat cactacaccc agaagagcct     1440

gtccctgtcc cccggcaagt gataataggc tggagcctcg gtggccatgc ttcttgcccc     1500

ttgggcctcc ccccagcccc tcctcccctt cctgcacccg taccccccaa acaccattgt     1560

cacactccag tggtctttga ataaagtctg agtgggcggc aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa tctag                                           1705


<210>  305
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  305

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  306
<211>  1646
<212>  DNA
<213>  Homo sapiens

<400>  306
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggaaac ccccgctcag ctgctgttcc      120

tgttgctgct gtggctgccc gacactaccg ggcaagtgca gctggtggag agcggcggcg      180

gcgtggtgca gcccggcaga agccttaggc tgagctgcgc cgccagtggc ttcaccttca      240

gcagctacgg catgcactgg gtgagacagg cccccggcaa gggcctggag tgggtggctg      300

tgatctggta cgacggcagc aacaagtact acgcagacag cgtgaaggga agattcacca      360

tcagccgcga caacagcaag aacaccctgt acctgcagat gaacagcctg agagctgagg      420

acaccgcagt gtactactgc gccagagacc ccaggggcgc caccctgtac tactattatt      480

acggcatgga tgtgtggggc cagggcacca ccgtgaccgt gtccagcgcc agcaccaagg      540

gcccaagcgt gttcccactt gccccatgca gcagaagcac cagcgagtca accgccgccc      600

tggggtgctt ggtgaaagac tacttccccg agcccgtgac cgtgagctgg aacagcggag      660

cactgaccag cggtgtgcac accttccccg ccgtgctgca gagcagcgga ctgtactccc      720

tgtccagcgt ggtcaccgtg cccagcagca acttcgggac tcaaacttac acttgcaacg      780

tggaccacaa accctccaat accaaggtgg ataaaaccgt ggagcggaag tgttgcgtgg      840

agtgccctcc ctgccccgcg cctcccgtgg ccggccccag cgtgttcctg ttcccaccca      900

agcctaagga tacactgatg atcagcagaa cccccgaggt cacttgcgtg gtggtggacg      960

tgagccacga ggacccggag gtgcagttta actggtacgt tgacggggtg gaggtgcaca     1020

acgctaagac caagcccaga gaagaacagt tcaacagcac cttcagggta gtgagcgtgc     1080

ttaccgtggt gcaccaggac tggctgaacg gcaaggagta caagtgcaag gtgagcaaca     1140

agggattgcc cgccccgatc gagaagacaa tctctaagac gaagggccag cccagagagc     1200

cccaggtgta caccctgccc cccagcagag aggagatgac caagaatcag gtgagcctga     1260

catgcttggt gaagggcttc taccccagcg acatcgccgt cgagtgggag agcaacggac     1320

agcccgagaa caactacaaa accaccccac ctatgctgga cagcgacggc agcttcttcc     1380

tgtactccaa actgaccgtg gataagagca gatggcagca gggcaacgtg tttagctgca     1440

gcgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgtct ttgagccccg     1500

ggaagtgata ataggctgga gcctcggtgg ccatgcttct tgccccttgg gcctcccccc     1560

agcccctcct ccccttcctg cacccgtacc ccccaaacac cattgtcaca ctccagtggt     1620

ctttgaataa agtctgagtg ggcggc                                          1646


<210>  307
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  307

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr 
        115                 120                 125             


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
145                 150                 155                 160 


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
305                 310                 315                 320 


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  308
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  308
atggaaaccc ccgctcagct gctgttcctg ttgctgctgt ggctgcccga cactaccggg       60

caagtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcagaag ccttaggctg      120

agctgcgccg ccagtggctt caccttcagc agctacggca tgcactgggt gagacaggcc      180

cccggcaagg gcctggagtg ggtggctgtg atctggtacg acggcagcaa caagtactac      240

gcagacagcg tgaagggaag attcaccatc agccgcgaca acagcaagaa caccctgtac      300

ctgcagatga acagcctgag agctgaggac accgcagtgt actactgcgc cagagacccc      360

aggggcgcca ccctgtacta ctattattac ggcatggatg tgtggggcca gggcaccacc      420

gtgaccgtgt ccagcgccag caccaagggc ccaagcgtgt tcccacttgc cccatgcagc      480

agaagcacca gcgagtcaac cgccgccctg gggtgcttgg tgaaagacta cttccccgag      540

cccgtgaccg tgagctggaa cagcggagca ctgaccagcg gtgtgcacac cttccccgcc      600

gtgctgcaga gcagcggact gtactccctg tccagcgtgg tcaccgtgcc cagcagcaac      660

ttcgggactc aaacttacac ttgcaacgtg gaccacaaac cctccaatac caaggtggat      720

aaaaccgtgg agcggaagtg ttgcgtggag tgccctccct gccccgcgcc tcccgtggcc      780

ggccccagcg tgttcctgtt cccacccaag cctaaggata cactgatgat cagcagaacc      840

cccgaggtca cttgcgtggt ggtggacgtg agccacgagg acccggaggt gcagtttaac      900

tggtacgttg acggggtgga ggtgcacaac gctaagacca agcccagaga agaacagttc      960

aacagcacct tcagggtagt gagcgtgctt accgtggtgc accaggactg gctgaacggc     1020

aaggagtaca agtgcaaggt gagcaacaag ggattgcccg ccccgatcga gaagacaatc     1080

tctaagacga agggccagcc cagagagccc caggtgtaca ccctgccccc cagcagagag     1140

gagatgacca agaatcaggt gagcctgaca tgcttggtga agggcttcta ccccagcgac     1200

atcgccgtcg agtgggagag caacggacag cccgagaaca actacaaaac caccccacct     1260

atgctggaca gcgacggcag cttcttcctg tactccaaac tgaccgtgga taagagcaga     1320

tggcagcagg gcaacgtgtt tagctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaaga gcctgtcttt gagccccggg aag                                  1413


<210>  309
<211>  1705
<212>  DNA
<213>  Homo sapiens

<400>  309
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg aaacccccgc       60

tcagctgctg ttcctgttgc tgctgtggct gcccgacact accgggcaag tgcagctggt      120

ggagagcggc ggcggcgtgg tgcagcccgg cagaagcctt aggctgagct gcgccgccag      180

tggcttcacc ttcagcagct acggcatgca ctgggtgaga caggcccccg gcaagggcct      240

ggagtgggtg gctgtgatct ggtacgacgg cagcaacaag tactacgcag acagcgtgaa      300

gggaagattc accatcagcc gcgacaacag caagaacacc ctgtacctgc agatgaacag      360

cctgagagct gaggacaccg cagtgtacta ctgcgccaga gaccccaggg gcgccaccct      420

gtactactat tattacggca tggatgtgtg gggccagggc accaccgtga ccgtgtccag      480

cgccagcacc aagggcccaa gcgtgttccc acttgcccca tgcagcagaa gcaccagcga      540

gtcaaccgcc gccctggggt gcttggtgaa agactacttc cccgagcccg tgaccgtgag      600

ctggaacagc ggagcactga ccagcggtgt gcacaccttc cccgccgtgc tgcagagcag      660

cggactgtac tccctgtcca gcgtggtcac cgtgcccagc agcaacttcg ggactcaaac      720

ttacacttgc aacgtggacc acaaaccctc caataccaag gtggataaaa ccgtggagcg      780

gaagtgttgc gtggagtgcc ctccctgccc cgcgcctccc gtggccggcc ccagcgtgtt      840

cctgttccca cccaagccta aggatacact gatgatcagc agaacccccg aggtcacttg      900

cgtggtggtg gacgtgagcc acgaggaccc ggaggtgcag tttaactggt acgttgacgg      960

ggtggaggtg cacaacgcta agaccaagcc cagagaagaa cagttcaaca gcaccttcag     1020

ggtagtgagc gtgcttaccg tggtgcacca ggactggctg aacggcaagg agtacaagtg     1080

caaggtgagc aacaagggat tgcccgcccc gatcgagaag acaatctcta agacgaaggg     1140

ccagcccaga gagccccagg tgtacaccct gccccccagc agagaggaga tgaccaagaa     1200

tcaggtgagc ctgacatgct tggtgaaggg cttctacccc agcgacatcg ccgtcgagtg     1260

ggagagcaac ggacagcccg agaacaacta caaaaccacc ccacctatgc tggacagcga     1320

cggcagcttc ttcctgtact ccaaactgac cgtggataag agcagatggc agcagggcaa     1380

cgtgtttagc tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct     1440

gtctttgagc cccgggaagt gataataggc tggagcctcg gtggccatgc ttcttgcccc     1500

ttgggcctcc ccccagcccc tcctcccctt cctgcacccg taccccccaa acaccattgt     1560

cacactccag tggtctttga ataaagtctg agtgggcggc aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa tctag                                           1705


<210>  310
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  310

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  311
<211>  935
<212>  DNA
<213>  Homo sapiens

<400>  311
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccctgcacag ctgctgttcc      120

tgctgctgct gtggctgccc gacaccaccg gcgacatcca gatgacccag agccccagct      180

ccctgagcgc cagcgtgggc gacagagtga ccatcacctg tagggccagc cagagcatca      240

atagctacct ggactggtac cagcagaagc ctggcaaggc ccccaagctg ctgatctacg      300

ccgccagcag cctgcaaagc ggcgtgccca gcagattcag cgggagcggc agcggcacag      360

actttacact gaccatcagc agcctgcagc ccgaggactt cgccacctac tactgccaac      420

agtattactc cacccccttt accttcggcc ccggaaccaa ggtggagatc aagagaaccg      480

tggccgcccc cagcgtgttc atcttccccc cctctgatga gcagctgaag agcggcaccg      540

ccagcgtggt gtgcctgctg aacaacttct atcccagaga ggccaaggtg cagtggaagg      600

tggacaacgc cctgcagagc ggcaacagcc aggagagcgt gactgagcag gacagcaagg      660

acagcaccta cagcctgagc agcaccctga cactgtcaaa ggccgattac gagaagcaca      720

aagtgtacgc ctgcgaggtg acccaccagg gcctgagcag ccccgtcacc aagagcttca      780

acaggggcga gtgctgataa taggctggag cctcggtggc catgcttctt gccccttggg      840

cctcccccca gcccctcctc cccttcctgc acccgtaccc cccaaacacc attgtcacac      900

tccagtggtc tttgaataaa gtctgagtgg gcggc                                 935


<210>  312
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  312

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  313
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  313
atggagaccc ctgcacagct gctgttcctg ctgctgctgt ggctgcccga caccaccggc       60

gacatccaga tgacccagag ccccagctcc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacctgta gggccagcca gagcatcaat agctacctgg actggtacca gcagaagcct      180

ggcaaggccc ccaagctgct gatctacgcc gccagcagcc tgcaaagcgg cgtgcccagc      240

agattcagcg ggagcggcag cggcacagac tttacactga ccatcagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccaacag tattactcca ccccctttac cttcggcccc      360

ggaaccaagg tggagatcaa gagaaccgtg gccgccccca gcgtgttcat cttccccccc      420

tctgatgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctat      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      540

gagagcgtga ctgagcagga cagcaaggac agcacctaca gcctgagcag caccctgaca      600

ctgtcaaagg ccgattacga gaagcacaaa gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagcagcc ccgtcaccaa gagcttcaac aggggcgagt gc                         702


<210>  314
<211>  994
<212>  DNA
<213>  Homo sapiens

<400>  314
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccctgc       60

acagctgctg ttcctgctgc tgctgtggct gcccgacacc accggcgaca tccagatgac      120

ccagagcccc agctccctga gcgccagcgt gggcgacaga gtgaccatca cctgtagggc      180

cagccagagc atcaatagct acctggactg gtaccagcag aagcctggca aggcccccaa      240

gctgctgatc tacgccgcca gcagcctgca aagcggcgtg cccagcagat tcagcgggag      300

cggcagcggc acagacttta cactgaccat cagcagcctg cagcccgagg acttcgccac      360

ctactactgc caacagtatt actccacccc ctttaccttc ggccccggaa ccaaggtgga      420

gatcaagaga accgtggccg cccccagcgt gttcatcttc cccccctctg atgagcagct      480

gaagagcggc accgccagcg tggtgtgcct gctgaacaac ttctatccca gagaggccaa      540

ggtgcagtgg aaggtggaca acgccctgca gagcggcaac agccaggaga gcgtgactga      600

gcaggacagc aaggacagca cctacagcct gagcagcacc ctgacactgt caaaggccga      660

ttacgagaag cacaaagtgt acgcctgcga ggtgacccac cagggcctga gcagccccgt      720

caccaagagc ttcaacaggg gcgagtgctg ataataggct ggagcctcgg tggccatgct      780

tcttgcccct tgggcctccc cccagcccct cctccccttc ctgcacccgt accccccaaa      840

caccattgtc acactccagt ggtctttgaa taaagtctga gtgggcggca aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaat ctag                                  994


<210>  315
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  315

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  316
<211>  935
<212>  DNA
<213>  Homo sapiens

<400>  316
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac ccccgcccag ctgctgttcc      120

tgctgctgct gtggctgccc gacacaaccg gcgacatcca gatgacccag agccctagca      180

gcctgagcgc cagcgtgggc gacagagtga ccatcacctg cagagccagc cagtccatca      240

acagctacct ggactggtac cagcagaagc ccggcaaggc ccccaaactg ctgatctatg      300

ctgccagctc actgcagagc ggcgtgccta gcagattcag cggctctggc agcggaaccg      360

acttcactct gaccatcagc agcctgcagc ccgaggactt cgccacctac tactgccagc      420

agtactacag cacccccttc accttcgggc ccggcactaa ggtggagatc aagagaaccg      480

tggccgcccc aagcgtgttc atcttccccc cctccgacga gcagctgaag agcggcaccg      540

ccagcgtggt gtgcctgctc aacaacttct accccagaga ggccaaggtg cagtggaagg      600

tggacaacgc cctgcagtcg ggcaacagcc aggagagcgt gaccgagcag gacagcaagg      660

acagcaccta cagcctgagc agcactctga ccctgagcaa ggctgattac gagaagcaca      720

aggtctacgc ctgcgaggtg acccaccagg gcctcagcag cccagtgacc aagagcttca      780

acagaggaga gtgctgataa taggctggag cctcggtggc catgcttctt gccccttggg      840

cctcccccca gcccctcctc cccttcctgc acccgtaccc cccaaacacc attgtcacac      900

tccagtggtc tttgaataaa gtctgagtgg gcggc                                 935


<210>  317
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  317

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  318
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  318
atggagaccc ccgcccagct gctgttcctg ctgctgctgt ggctgcccga cacaaccggc       60

gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggcga cagagtgacc      120

atcacctgca gagccagcca gtccatcaac agctacctgg actggtacca gcagaagccc      180

ggcaaggccc ccaaactgct gatctatgct gccagctcac tgcagagcgg cgtgcctagc      240

agattcagcg gctctggcag cggaaccgac ttcactctga ccatcagcag cctgcagccc      300

gaggacttcg ccacctacta ctgccagcag tactacagca cccccttcac cttcgggccc      360

ggcactaagg tggagatcaa gagaaccgtg gccgccccaa gcgtgttcat cttccccccc      420

tccgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctcaa caacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtcggg caacagccag      540

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag cactctgacc      600

ctgagcaagg ctgattacga gaagcacaag gtctacgcct gcgaggtgac ccaccagggc      660

ctcagcagcc cagtgaccaa gagcttcaac agaggagagt gc                         702


<210>  319
<211>  994
<212>  DNA
<213>  Homo sapiens

<400>  319
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agacccccgc       60

ccagctgctg ttcctgctgc tgctgtggct gcccgacaca accggcgaca tccagatgac      120

ccagagccct agcagcctga gcgccagcgt gggcgacaga gtgaccatca cctgcagagc      180

cagccagtcc atcaacagct acctggactg gtaccagcag aagcccggca aggcccccaa      240

actgctgatc tatgctgcca gctcactgca gagcggcgtg cctagcagat tcagcggctc      300

tggcagcgga accgacttca ctctgaccat cagcagcctg cagcccgagg acttcgccac      360

ctactactgc cagcagtact acagcacccc cttcaccttc gggcccggca ctaaggtgga      420

gatcaagaga accgtggccg ccccaagcgt gttcatcttc cccccctccg acgagcagct      480

gaagagcggc accgccagcg tggtgtgcct gctcaacaac ttctacccca gagaggccaa      540

ggtgcagtgg aaggtggaca acgccctgca gtcgggcaac agccaggaga gcgtgaccga      600

gcaggacagc aaggacagca cctacagcct gagcagcact ctgaccctga gcaaggctga      660

ttacgagaag cacaaggtct acgcctgcga ggtgacccac cagggcctca gcagcccagt      720

gaccaagagc ttcaacagag gagagtgctg ataataggct ggagcctcgg tggccatgct      780

tcttgcccct tgggcctccc cccagcccct cctccccttc ctgcacccgt accccccaaa      840

caccattgtc acactccagt ggtctttgaa taaagtctga gtgggcggca aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaat ctag                                  994


<210>  320
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  320

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  321
<211>  935
<212>  DNA
<213>  Homo sapiens

<400>  321
tcaagctttt ggaccctcgt acagaagcta atacgactca ctatagggaa ataagagaga       60

aaagaagagt aagaagaaat ataagagcca ccatggagac tcccgcccag ctgctgttcc      120

tgttgctgct gtggctgccc gacaccacag gggacatcca gatgactcag agtcccagca      180

gcctgagcgc cagcgtcggc gacagagtta ccatcacctg ccgggccagc cagagcatta      240

acagctacct ggactggtac cagcagaagc ctggaaaggc ccccaagctg ctgatctacg      300

ccgccagcag cctgcagagc ggcgtgccta gcagattcag cggcagcgga agcggcaccg      360

acttcaccct aaccatcagc agtctgcagc cagaggactt cgcgacctac tactgccagc      420

agtactactc aacacccttc accttcggcc ccggcaccaa ggtggagatc aagagaaccg      480

tggccgcccc ctctgtgttc atcttccccc ccagcgacga gcagctgaag tccggcaccg      540

caagcgtggt gtgcctgctg aacaacttct accccagaga ggccaaggtg cagtggaagg      600

tggacaacgc cctgcagtcc ggcaacagcc aggagagcgt gaccgagcag gacagcaagg      660

actccaccta cagcctcagc agcacactga ccctgagcaa ggccgactac gagaagcaca      720

aggtgtacgc ctgcgaggtg acccaccagg gcctgagcag ccccgtgacc aagagcttca      780

acagaggaga gtgctgataa taggctggag cctcggtggc catgcttctt gccccttggg      840

cctcccccca gcccctcctc cccttcctgc acccgtaccc cccaaacacc attgtcacac      900

tccagtggtc tttgaataaa gtctgagtgg gcggc                                 935


<210>  322
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  322

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr 
            100                 105                 110         


Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  323
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  323
atggagactc ccgcccagct gctgttcctg ttgctgctgt ggctgcccga caccacaggg       60

gacatccaga tgactcagag tcccagcagc ctgagcgcca gcgtcggcga cagagttacc      120

atcacctgcc gggccagcca gagcattaac agctacctgg actggtacca gcagaagcct      180

ggaaaggccc ccaagctgct gatctacgcc gccagcagcc tgcagagcgg cgtgcctagc      240

agattcagcg gcagcggaag cggcaccgac ttcaccctaa ccatcagcag tctgcagcca      300

gaggacttcg cgacctacta ctgccagcag tactactcaa cacccttcac cttcggcccc      360

ggcaccaagg tggagatcaa gagaaccgtg gccgccccct ctgtgttcat cttccccccc      420

agcgacgagc agctgaagtc cggcaccgca agcgtggtgt gcctgctgaa caacttctac      480

cccagagagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caacagccag      540

gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctcagcag cacactgacc      600

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      660

ctgagcagcc ccgtgaccaa gagcttcaac agaggagagt gc                         702


<210>  324
<211>  994
<212>  DNA
<213>  Homo sapiens

<400>  324
ggaaataaga gagaaaagaa gagtaagaag aaatataaga gccaccatgg agactcccgc       60

ccagctgctg ttcctgttgc tgctgtggct gcccgacacc acaggggaca tccagatgac      120

tcagagtccc agcagcctga gcgccagcgt cggcgacaga gttaccatca cctgccgggc      180

cagccagagc attaacagct acctggactg gtaccagcag aagcctggaa aggcccccaa      240

gctgctgatc tacgccgcca gcagcctgca gagcggcgtg cctagcagat tcagcggcag      300

cggaagcggc accgacttca ccctaaccat cagcagtctg cagccagagg acttcgcgac      360

ctactactgc cagcagtact actcaacacc cttcaccttc ggccccggca ccaaggtgga      420

gatcaagaga accgtggccg ccccctctgt gttcatcttc ccccccagcg acgagcagct      480

gaagtccggc accgcaagcg tggtgtgcct gctgaacaac ttctacccca gagaggccaa      540

ggtgcagtgg aaggtggaca acgccctgca gtccggcaac agccaggaga gcgtgaccga      600

gcaggacagc aaggactcca cctacagcct cagcagcaca ctgaccctga gcaaggccga      660

ctacgagaag cacaaggtgt acgcctgcga ggtgacccac cagggcctga gcagccccgt      720

gaccaagagc ttcaacagag gagagtgctg ataataggct ggagcctcgg tggccatgct      780

tcttgcccct tgggcctccc cccagcccct cctccccttc ctgcacccgt accccccaaa      840

caccattgtc acactccagt ggtctttgaa taaagtctga gtgggcggca aaaaaaaaaa      900

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaaaat ctag                                  994


<210>  325
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  325

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Ser Tyr 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Phe 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


