                         SEQUENCE LISTING

<110>  Brian, Lichty
       Bell, John
 
<120>  Oncolytic Virus and Checkpoint Inhibitor Combination Therapy

<130>  103920W-90

<140>  PCT/CA2017/050031
<141>  2017-01-11

<150>  US 62/277,352
<151>  2016-01-11

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  1

Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  2

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  3

Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  4

Thr Phe Pro Asp Leu Glu Ser Glu Phe 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  5

Val Ala Glu Leu Val His Phe Leu Leu 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  6

Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  7

Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  8

Arg Glu Pro Val Thr Lys Ala Glu Met Leu 
1               5                   10  


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  9

Ala Glu Leu Val His Phe Leu Leu Leu 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  10

Met Glu Val Asp Pro Ile Gly His Leu Tyr 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  11

Trp Gln Tyr Phe Phe Pro Val Ile Phe 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  12

Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  13

Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  14

Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  15

Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  16

Ala Cys Tyr Glu Phe Leu Trp Gly Pro Arg Ala Leu Val Glu Thr Ser 
1               5                   10                  15      


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  17

Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  18

Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
1               5                   10          


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  19

Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
1               5                   10          


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  20

Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  21

Gly Asp Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  22

Thr Ser Tyr Val Lys Val Leu His His Met Val Lys Ile Ser Gly 
1               5                   10                  15  


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  23

Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala 
1               5                   10                  15      


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  24

Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu Pro Val Thr Lys Ala Glu 
1               5                   10                  15      


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  25

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  26

Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  27

Glu Gly Asp Cys Ala Pro Glu Glu Lys 
1               5                   


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  28

Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  29

Arg Lys Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg 
1               5                   10                  15  


<210>  30
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic epitope from human MAGEA3 protein

<400>  30

Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu Tyr 
1               5                   10                  15      


<210>  31
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Antibody chain polypeptide

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  32
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Antibody chain polypeptide

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  33
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Antibody chain polypeptide

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  34
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Antibody chain polypeptide

<400>  34

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  35
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Trp Gly Asn Trp Gln Tyr 
    130                 135                 140                 


Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu Val 
145                 150                 155                 160 


Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr Ile 
                165                 170                 175     


Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn 
            180                 185                 190         


Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile Ile 
        195                 200                 205             


Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu Leu 
    210                 215                 220                 


Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly Asp 
225                 230                 235                 240 


Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu 
                245                 250                 255     


Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu Trp 
            260                 265                 270         


Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His His 
        275                 280                 285             


Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu His 
    290                 295                 300                 


Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310             


<210>  36
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  36
atgcctcttg agcagaggag tcagcactgc aagcctgaag aaggccttga ggcccgagga       60

gaggccctgg gcctggtggg tgcgcaggct cctgctactg aggagcagga ggctgcctcc      120

tcctcttcta ctctagttga agtcaccctg ggggaggtgc ctgctgccga gtcaccagat      180

cctccccaga gtcctcaggg agcctccagc ctccccacta ccatgaacta ccctctctgg      240

agccaatcct atgaggactc cagcaaccaa gaagaggagg ggccaagcac cttccctgac      300

ctggagtccg agttccaagc agcactcagt aggaaggtgg ccgagttggt tcattttctg      360

ctcctcaagt atcgagccag ggagccggtc acaaaggcag aaatgctggg gagtgtcgtc      420

ggaaattggc agtatttctt tcctgtgatc ttcagcaaag cttccagttc cttgcagctg      480

gtctttggca tcgagctgat ggaagtggac cccatcggcc acttgtacat ctttgccacc      540

tgcctgggcc tctcctacga tggcctgctg ggtgacaatc agatcatgcc caaggcaggc      600

ctcctgataa tcgtcctggc cataatcgca agagagggcg actgtgcccc tgaggagaaa      660

atctgggagg agctgagtgt gttagaggtg tttgagggga gggaagacag tatcttgggg      720

gatcccaaga agctgctcac ccaacatttc gtgcaggaaa actacctgga gtaccggcag      780

gtccccggca gtgatcctgc atgttatgaa ttcctgtggg gtccaagggc cctcgttgaa      840

accagctatg tgaaagtcct gcaccatatg gtaaagatca gtggaggacc tcacatttcc      900

tacccacccc tgcatgagtg ggttttgaga gagggggaag agtga                      945


<210>  37
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized nucleotide sequence encoding full length, wild 
       type, human MAGEA3 protein

<400>  37
atgcccctgg agcagcggtc tcagcattgc aagccagagg agggcctcga ggcgaggggc       60

gaggccctcg gcttggtggg ggcgcaggct cctgcaaccg aggagcaaga ggccgcatcc      120

agttcctcta ccctggttga ggtgaccttg ggtgaggtgc ccgccgcgga gagccccgac      180

ccgcctcaaa gcccccaggg tgccagctcc ctgcccacaa caatgaacta cccactctgg      240

agtcagtctt acgaggacag tagtaaccaa gaggaggagg gaccctccac attcccagac      300

ctggagtctg aattccaggc agcattgtct agaaaagtgg ccgaattggt gcacttcctg      360

ctgctgaagt atcgcgcccg cgagccagtc acaaaagctg aaatgctggg ttctgtcgtg      420

ggaaattggc agtacttctt ccccgtgatc ttcagtaaag cgtccagctc cttgcagctg      480

gtctttggta tcgagctgat ggaggtggat cccatcggcc atctgtatat ctttgccaca      540

tgcctgggcc tgagctacga tggcctgctg ggcgacaacc agatcatgcc aaaagctggc      600

ctgctgatca tcgttctggc tatcatcgct agagaaggag attgcgcccc tgaagaaaag      660

atctgggagg aactgagcgt cctggaagtc tttgagggtc gtgaagacag cattctcggg      720

gatcccaaga agctgctgac ccagcacttc gtgcaggaga actatctgga gtaccgccag      780

gttcccggca gcgaccccgc ttgctacgag ttcctgtggg gccccagggc cctggtcgag      840

acatcctacg tgaaggtcct gcaccatatg gttaaaatca gcggcggccc ccatatctct      900

tatccgccgc tccacgagtg ggtgctccgg gagggagagg ag                         942


<210>  38
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of MAGEA3 protein derived from homo sapiens

<400>  38

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Trp Gly Asn Trp Gln Tyr 
    130                 135                 140                 


Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu Val 
145                 150                 155                 160 


Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr Ile 
                165                 170                 175     


Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp Asn 
            180                 185                 190         


Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile Ile 
        195                 200                 205             


Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu Leu 
    210                 215                 220                 


Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly Asp 
225                 230                 235                 240 


Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu Glu 
                245                 250                 255     


Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu Trp 
            260                 265                 270         


Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His His 
        275                 280                 285             


Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu His 
    290                 295                 300                 


Glu Trp Val Leu Arg Glu Gly Glu Glu Asp Tyr Lys Asp Asp Asp Asp 
305                 310                 315                 320 


Lys 
    


<210>  39
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding variant of MAGEA3 protein derived 
       from homo sapiens

<400>  39
atgcccctgg aacagcggag ccagcactgc aagcccgagg aaggcctgga agccagaggc       60

gaagccctgg gactggtggg agcccaggcc cctgccacag aagaacagga agccgccagc      120

agcagctcca ccctggtgga agtgaccctg ggcgaagtgc ctgccgccga gagccctgat      180

ccccctcagt ctcctcaggg cgccagcagc ctgcccacca ccatgaacta ccccctgtgg      240

tcccagagct acgaggacag cagcaaccag gaagaggaag gccccagcac cttccccgac      300

ctggaaagcg agttccaggc cgccctgagc cggaaggtgg cagagctggt gcacttcctg      360

ctgctgaagt acagagcccg cgagcccgtg accaaggccg agatgctggg cagcgtggtg      420

ggaaactggc agtacttctt ccccgtgatc ttctccaagg ccagcagctc cctgcagctg      480

gtgttcggca tcgagctgat ggaagtggac cccatcggcc acctgtacat cttcgccacc      540

tgtctgggcc tgagctacga cggcctgctg ggcgacaacc agatcatgcc caaggccggc      600

ctgctgatca tcgtgctggc catcattgcc cgcgagggcg actgcgcccc tgaggaaaag      660

atctgggagg aactgagcgt gctggaagtg ttcgagggca gagaggacag catcctgggc      720

gaccccaaga agctgctgac ccagcacttc gtgcaggaaa actacctgga ataccgccag      780

gtgcccggca gcgaccccgc ctgttacgag ttcctgtggg gccccagggc tctggtggaa      840

accagctacg tgaaggtgct gcaccacatg gtgaaaatca gcggcggacc ccacatcagc      900

taccccccac tgcacgagtg ggtgctgaga gagggcgaag aggactacaa ggacgacgac      960

gacaaatga                                                              969


<210>  40
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein derived from E6 and E7 proteins of human papilloma
       virus

<400>  40

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Asp Lys Leu Lys Phe Tyr Ser Lys Ile Ser Glu 
65                  70                  75                  80  


Tyr Arg His Tyr Cys Tyr Ser Val Tyr Gly Thr Thr Leu Glu Gln Gln 
                85                  90                  95      


Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Ile Asn Gln Lys Pro 
            100                 105                 110         


Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys Lys Gln Arg Phe 
        115                 120                 125             


His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met Ser Cys Cys Arg 
    130                 135                 140                 


Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu Gly Gly Gly Gly Gly Ala 
145                 150                 155                 160 


Ala Tyr Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu 
                165                 170                 175     


Pro Asp Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile 
            180                 185                 190         


Thr Cys Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu 
        195                 200                 205             


Phe Ala Phe Lys Asp Leu Phe Trp Tyr Arg Asp Ser Ile Pro His Ala 
    210                 215                 220                 


Ala His Lys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His Tyr 
225                 230                 235                 240 


Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr Gly 
                245                 250                 255     


Leu Tyr Asn Leu Leu Ile Arg Leu Arg Gln Lys Pro Leu Asn Pro Ala 
            260                 265                 270         


Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg Phe His Asn Ile Ala 
        275                 280                 285             


Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys Asn Arg Ala Arg Gln 
    290                 295                 300                 


Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Ala Ala Tyr Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu 
                325                 330                 335     


Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Gln Leu Asn Asp Ser Ser 
            340                 345                 350         


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        355                 360                 365             


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    370                 375                 380                 


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
385                 390                 395                 400 


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Pro Ile Cys Ser Gln Lys 
                405                 410                 415     


Pro Gly Gly Gly Gly Gly Ala Ala Tyr Met His Gly Pro Lys Ala Thr 
            420                 425                 430         


Leu Gln Asp Ile Val Leu His Leu Glu Pro Gln Asn Glu Ile Pro Val 
        435                 440                 445             


Asp Leu Leu Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp 
    450                 455                 460                 


Gly Val Asn His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg 
465                 470                 475                 480 


His Thr Met Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu 
                485                 490                 495     


Trp Glu Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu 
            500                 505                 510         


Asn Thr Leu Ser Phe Val Pro Trp Cys Ala Ser Gln Gln 
        515                 520                 525 


<210>  41
<211>  1584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence encoding fusion protein derived from E6 and 
       E7 proteins of human papilloma virus

<400>  41
atgcatcaga agcgaactgc tatgtttcag gaccctcagg agcggccacg caaactgcct       60

cagctgtgca ccgaactgca gacaactatc cacgacatca ttctggaatg cgtgtactgt      120

aagcagcagc tgctgaggag agaggtctat gacttcgctt ttcgcgatct gtgcatcgtg      180

taccgagacg gaaacccata tgcagtcgat aagctgaagt tctacagcaa gatctccgaa      240

tacaggcatt actgttacag cgtgtacggg accacactgg agcagcagta taacaagccc      300

ctgtgcgacc tgctgatcag aattaatcag aagcccctgt gccctgagga aaaacagagg      360

cacctggata agaaacagag atttcataac atccgaggac gatggaccgg gcggtgcatg      420

tcctgctgta gaagctcccg gactcgacga gagacccagc tgggcggagg aggaggagca      480

gcttacatgg cacgattcga ggaccctacc cgaaggccat ataagctgcc cgacctgtgc      540

acagaactga atacttctct gcaggacatc gagattacat gcgtgtactg taaaaccgtc      600

ctggagctga cagaagtgtt cgagtttgct ttcaaggacc tgtttgtggt ctaccgggat      660

tcaatccctc acgcagccca taaaatcgac ttctacagca ggatcaggga actgcgccac      720

tactccgaca gcgtgtacgg ggatacactg gagaagctga caaacactgg cctgtacaat      780

ctgctgatcc gactgcgaca gaagccactg aacccagccg aaaaactgag acacctgaac      840

gagaagagac ggtttcacaa tattgcaggc cattataggg gacagtgcca tagttgctgt      900

aatcgagcca ggcaggaaag actgcagcgc cgaagggaga ctcaagtcgg cggaggagga      960

ggagctgcat acatgcacgg cgacaccccc acactgcatg aatatatgct ggatctgcag     1020

cctgagacta ccgacctgta ccagctgaac gattctagtg aggaagagga cgaaatcgac     1080

ggaccagcag gacaggcaga gcctgaccgg gcccactata atattgtgac attctgctgt     1140

aagtgcgatt ctactctgcg gctgtgcgtg cagagtactc atgtcgacat ccgcaccctg     1200

gaggatctgc tgatggggac tctgggcatc gtcccaattt gtagccagaa accaggcggc     1260

ggcggcggag cagcttacat gcacggaccc aaggctaccc tgcaggacat cgtgctgcat     1320

ctggaacctc agaatgagat tccagtcgac ctgctgcagc tgagtgattc agaagaggaa     1380

aacgacgaga tcgacggcgt gaatcaccag catctgcctg ctagacgggc agagccacag     1440

cgacacacaa tgctgtgcat gtgctgtaag tgtgaagcca ggatcaagct ggtggtcgag     1500

tcaagcgccg acgatctgcg cgccttccag cagctgttcc tgaatactct gtcatttgtc     1560

ccttggtgtg cctcccagca gtga                                            1584


<210>  42
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Glu Ser Arg Lys Asp Ile Thr Asn Gln Glu Glu Leu Trp Lys Met 
1               5                   10                  15      


Lys Pro Arg Arg Asn Leu Glu Glu Asp Asp Tyr Leu His Lys Asp Thr 
            20                  25                  30          


Gly Glu Thr Ser Met Leu Lys Arg Pro Val Leu Leu His Leu His Gln 
        35                  40                  45              


Thr Ala His Ala Asp Glu Phe Asp Cys Pro Ser Glu Leu Gln His Thr 
    50                  55                  60                  


Gln Glu Leu Phe Pro Gln Trp His Leu Pro Ile Lys Ile Ala Ala Ile 
65                  70                  75                  80  


Ile Ala Ser Leu Thr Phe Leu Tyr Thr Leu Leu Arg Glu Val Ile His 
                85                  90                  95      


Pro Leu Ala Thr Ser His Gln Gln Tyr Phe Tyr Lys Ile Pro Ile Leu 
            100                 105                 110         


Val Ile Asn Lys Val Leu Pro Met Val Ser Ile Thr Leu Leu Ala Leu 
        115                 120                 125             


Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Val Gln Leu His Asn Gly 
    130                 135                 140                 


Thr Lys Tyr Lys Lys Phe Pro His Trp Leu Asp Lys Trp Met Leu Thr 
145                 150                 155                 160 


Arg Lys Gln Phe Gly Leu Leu Ser Phe Phe Phe Ala Val Leu His Ala 
                165                 170                 175     


Ile Tyr Ser Leu Ser Tyr Pro Met Arg Arg Ser Tyr Arg Tyr Lys Leu 
            180                 185                 190         


Leu Asn Trp Ala Tyr Gln Gln Val Gln Gln Asn Lys Glu Asp Ala Trp 
        195                 200                 205             


Ile Glu His Asp Val Trp Arg Met Glu Ile Tyr Val Ser Leu Gly Ile 
    210                 215                 220                 


Val Gly Leu Ala Ile Leu Ala Leu Leu Ala Val Thr Ser Ile Pro Ser 
225                 230                 235                 240 


Val Ser Asp Ser Leu Thr Trp Arg Glu Phe His Tyr Ile Gln Ser Lys 
                245                 250                 255     


Leu Gly Ile Val Ser Leu Leu Leu Gly Thr Ile His Ala Leu Ile Phe 
            260                 265                 270         


Ala Trp Asn Lys Trp Ile Asp Ile Lys Gln Phe Val Trp Tyr Thr Pro 
        275                 280                 285             


Pro Thr Phe Met Ile Ala Val Phe Leu Pro Ile Trp Leu Ile Phe Lys 
    290                 295                 300                 


Ser Ile Leu Phe Leu Pro Cys Leu Arg Lys Lys Ile Leu Lys Ile Arg 
305                 310                 315                 320 


His Gly Trp Glu Asp Val Thr Lys Ile Asn Lys Thr Glu Ile Cys Ser 
                325                 330                 335     


Gln Leu Lys Leu 
            340 


<210>  43
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  43
atggaatcac ggaaggacat cactaatcag gaggaactgt ggaaaatgaa gccaagaagg       60

aatctggaag aggacgacta tctgcacaag gacaccggcg aaacaagtat gctgaaacga      120

ccagtgctgc tgcacctgca tcagactgct cacgcagacg agtttgattg cccctctgaa      180

ctgcagcaca cccaggagct gttcccacag tggcatctgc ccatcaagat tgccgctatc      240

attgcttcac tgacatttct gtacactctg ctgagagaag tgatccaccc cctggccacc      300

agccatcagc agtacttcta taagatccct atcctggtca tcaacaaggt cctgccaatg      360

gtgagcatca cactgctggc cctggtctac ctgcctggag tgatcgcagc cattgtccag      420

ctgcacaatg ggacaaagta taagaaattt ccacattggc tggataagtg gatgctgact      480

aggaaacagt tcggactgct gtccttcttt ttcgccgtgc tgcacgctat ctacagcctg      540

tcctatccca tgaggaggag ctaccggtat aagctgctga actgggctta ccagcaggtg      600

cagcagaaca aggaggacgc atggattgaa catgacgtgt ggcgcatgga aatctacgtg      660

agcctgggca ttgtcggact ggccatcctg gctctgctgg cagtgaccag tatcccttct      720

gtcagtgact cactgacatg gagagagttt cactacattc agagcaagct ggggatcgtg      780

tccctgctgc tgggcaccat ccatgcactg atttttgcct ggaacaagtg gatcgatatc      840

aagcagttcg tgtggtatac tccccctacc tttatgattg ccgtcttcct gcccatcgtg      900

gtcctgatct tcaagtccat cctgttcctg ccttgtctgc ggaagaaaat cctgaaaatt      960

cggcacggat gggaggatgt caccaaaatc aataagactg aaatctgtag ccagctgaag     1020

ctttaa                                                                1026


<210>  44
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  45
<211>  543
<212>  DNA
<213>  Homo sapiens

<400>  45
atgcaggccg agggcagagg cacaggcgga tctacaggcg acgccgatgg ccctggcggc       60

cctggaattc ctgacggacc tggcggcaat gccggcggac ccggagaagc tggcgccaca      120

ggcggaagag gacctagagg cgctggcgcc gctagagctt ctggaccagg cggaggcgcc      180

cctagaggac ctcatggcgg agccgcctcc ggcctgaacg gctgttgcag atgtggagcc      240

agaggccccg agagccggct gctggaattc tacctggcca tgcccttcgc cacccccatg      300

gaagccgagc tggccagacg gtccctggcc caggatgctc ctcctctgcc tgtgcccggc      360

gtgctgctga aagaattcac cgtgtccggc aacatcctga ccatccggct gactgccgcc      420

gaccacagac agctccagct gtctatcagc tcctgcctgc agcagctgag cctgctgatg      480

tggatcaccc agtgctttct gcccgtgttc ctggctcagc cccccagcgg ccagagaaga      540

tga                                                                    543


