               SEQUENCE LISTING

<110> Bayer Pharma AG

<120> 2-(Morpholin-4-yl)-1,7-naphthyridines

<130> BHC143030

<160> 4

<170> BiSSAP 1.3

<210> 1
<211> 8697
<212> DNA
<213> synthetic organisms

<220> 
<223> Codon-optimized ATR including GST tag

<400> 1
atggcctccc ctatactagg ttattggaaa attaagggcc ttgtgcaacc cactcgactt       60

cttttggaat atcttgaaga aaaatatgaa gagcatttgt atgagcgcga tgaaggtgat      120

aaatggcgaa acaaaaagtt tgaattgggt ttggagtttc ccaatcttcc ttattatatt      180

gatggtgatg ttaaattaac acagtctatg gccatcatac gttatatagc tgacaagcac      240

aacatgttgg gtggttgtcc aaaagagcgt gcagagattt caatgcttga aggagcggtt      300

ttggatatta gatacggtgt ttcgagaatt gcatatagta aagactttga aactctcaaa      360

gttgattttc ttagcaagct acctgaaatg ctgaaaatgt tcgaagatcg tttatgtcat      420

aaaacatatt taaatggtga tcatgtaacc catcctgact tcatgttgta tgacgctctt      480

gatgttgttt tatacatgga cccaatgtgc ctggatgcgt tcccaaaatt agtttgtttt      540

aaaaaacgta ttgaagctat cccacaaatt gataagtact tgaaatccag caagtatata      600

gcatggcctt tgcagggctg gcaagccacg tttggtggtg gcgaccatcc tccaaaatcg      660

gatcagatca caagtttgta caaaaaagca ggctccgact atgacattcc aactacggag      720

aatttgtact tccaaggcga ctacaaggac gacgatgata agatgggtga acatggtttg      780

gagctcgcat ccatgattcc agccctgcgt gaactgggct ccgcaactcc agaggagtac      840

aacacggtgg tgcaaaaacc gcgtcagata ctgtgccagt tcatcgacag aatcctgacg      900

gatgtgaacg tggtggctgt cgagctcgtc aaaaagaccg attctcaacc aacgtccgtc      960

atgctgttgg actttatcca acacatcatg aaatcctccc cgctgatgtt cgttaacgtt     1020

tctggatccc acgaggctaa aggctcctgc atcgagttct caaactggat tatcaccaga     1080

ctgttgcgta ttgctgccac gcctagctgt cacttgctcc acaagaagat ctgcgaagta     1140

atatgctccc tgctgtttct gttcaagtcc aaatcacccg ctatatttgg agttctgaca     1200

aaggaattgt tgcagctgtt tgaggacctg gtatacttgc ataggcgtaa cgtgatgggt     1260

catgccgtcg agtggcctgt cgtcatgtct cgcttcctgt ctcagctcga cgaacatatg     1320

ggttatctcc agtccgcacc actccagttg atgtccatgc aaaacctgga gttcatagaa     1380

gtgacgttgc tcatggtgct gactagaatc attgctattg tgttcttccg ccgtcaagag     1440

ttgttgttgt ggcaaatcgg ctgcgtgttg ctggagtatg gctccccaaa gattaagagc     1500

ttggctatat cctttctgac agaactgttc cagctcggcg gtctgccggc ccagccggct     1560

tccacattct tctcctcatt cctggaactg ctgaagcacc tcgttgagat ggacacggac     1620

caactcaagc tgtacgaaga gcccttgtcc aaattgatta agacactgtt cccctttgag     1680

gcagaggcgt acaggaacat cgagcccgta tatctgaaca tgctgctgga gaagctctgc     1740

gtgatgtttg aagatggagt actgatgcgc ctgaagtccg atctgctgaa ggctgctctg     1800

tgtcatctcc tgcaatactt cttgaaattc gttcctgccg gttacgagtc cgctttgcaa     1860

gtacgcaagg tgtacgtacg taatatctgc aaggctctgc tggacgtgct cggtattgag     1920

gtagacgccg aatatctgtt gggcccattg tacgctgcgc tgaaaatgga gtcaatggaa     1980

atcattgagg aaatccagtg ccagacccag caagaaaatc tgagctccaa ctccgacgga     2040

atttctccaa agaggcgccg cttgagcagc tccctgaacc cttcaaagcg tgcaccaaag     2100

cagactgagg aaatcaagca cgtggacatg aaccaaaaga gcatactgtg gtccgcattg     2160

aagcagaaag ccgagtcttt gcagatttcc ctcgaatatt ccggcctgaa aaatcccgta     2220

attgaaatgc tcgagggcat cgccgtagtt ttgcaactga ccgctctgtg tactgtgcac     2280

tgctctcatc agaacatgaa ctgcaggaca ttcaaggact gccagcataa gtctaaaaag     2340

aagccctcag tcgtcatcac ttggatgtct ttggatttct ataccaaggt cctgaagtcc     2400

tgtcgtagcc tgctggagtc agtgcaaaag ttggatctgg aagccaccat cgataaagta     2460

gttaagattt acgacgccct catctacatg caagtcaact ccagcttcga ggaccatatc     2520

ctcgaagatc tgtgcggtat gctgagcctc ccttggatct acagccactc cgatgacgga     2580

tgtctgaagc tcaccacttt tgccgcaaat ttgttgaccc tgtcttgccg catatccgac     2640

tcatattcac ctcaagccca atcccgttgt gtattcctgc tcaccctgtt cccacgtcgt     2700

atttttctgg aatggagaac cgccgtatac aactgggctc tgcagtcctc ccacgaagtg     2760

ataagagcct catgtgtctc cggcttcttc atcttgctgc agcaacaaaa ctcttgtaat     2820

cgcgtcccga agatcctgat cgataaggtc aaggacgact ccgacattgt gaagaaagaa     2880

tttgccagca tcttgggcca gctggtctgc acactccacg gtatgttcta cctcacttcc     2940

agcttgacag aacccttctc cgagcatgga cacgtcgatc tgttttgtag gaatctgaaa     3000

gcaacttcac agcacgaatg ctcctcctcc cagctcaaag cctctgtctg caagcccttt     3060

ctgtttctgc tgaaaaagaa aatcccatca ccggttaaac tcgctttcat cgacaatctc     3120

caccacctgt gcaagcatct ggatttcagg gaggatgaga cagatgtgaa ggccgttctg     3180

ggtactctgc tcaacctgat ggaggaccca gacaaggacg tgagagtggc tttctccggt     3240

aacattaagc atatcctgga aagcctcgat agcgaggacg gatttatcaa agaattgttc     3300

gtcctgcgca tgaaggaagc ttacacgcat gcgcagatct ctcgtaataa cgagctgaag     3360

gacaccctga tattgacaac tggtgatatc ggaagagctg ccaagggcga tttggtgccg     3420

ttcgcgctgc tgcatttgct gcactgcctg ctgtctaagt ccgcttctgt ctctggcgct     3480

gcatacaccg aaattagggc gctggtggct gctaagtccg ttaaactcca gtctttcttc     3540

tcccagtaca aaaaacctat ttgccaattc ttggttgagt ccctgcactc ctcccagatg     3600

accgctctgc ccaacacacc ctgtcagaac gcagatgttc gcaaacagga cgttgcccac     3660

cagagggaga tggcactgaa tacactgtcc gagattgcta atgtgttcga ctttcccgat     3720

ctgaacaggt tcctgactcg tactctccag gtactgctgc ctgacctcgc cgctaaagcc     3780

tctccagctg cttcagccct gatccgtacc ctgggtaaac agctgaatgt caataggaga     3840

gaaatattga tcaacaactt caaatacatc ttttcacacc tggtatgctc ctgctctaag     3900

gacgagctgg agcgtgctct gcattatctg aagaacgaaa ccgaaataga actgggttcc     3960

ttgctccgcc aagatttcca aggtctgcat aacgagctgc tgctcaggat cggcgagcat     4020

taccagcaag tgttcaatgg tttgtcaatt ttggcgtcct tcgcctcctc cgacgaccca     4080

tatcagggcc ctagagacat catcagccca gaactgatgg ctgattatct gcaacctaag     4140

ttgctcggaa tcctcgcatt tttcaacatg caactgttgt caagctcagt cggcattgaa     4200

gataaaaaga tggcgctcaa ctcactgatg agcctcatga agctgatggg cccaaagcat     4260

gtctcctccg tgagggttaa gatgatgacc actctgagga ctggcctgag gtttaaggac     4320

gatttccctg aactgtgctg ccgtgcctgg gattgtttcg tccgttgcct cgatcacgcc     4380

tgtctcggtt ccctgctgtc ccacgtcatc gtggcactct tgccactgat tcacatacag     4440

cccaaggaaa cggccgcgat atttcactac ctcatcatcg aaaaccgtga cgcggtccag     4500

gatttcctgc atgagatcta cttcctgccc gaccacccgg aactgaagaa gatcaaggcc     4560

gttctgcagg aatatcgtaa agaaacctcc gagtccaccg atctgcagac caccctgcag     4620

ttgtcaatga aggcaatcca acatgagaac gtcgacgtca gaatacacgc actgacctct     4680

ctgaaggaaa cactgtacaa gaaccaagag aagttgatca aatacgctac tgactcagag     4740

acagtagaac ccatcatctc acagctcgtg accgttctcc tcaagggttg ccaggacgct     4800

aactctcagg cgagattgct gtgtggcgag tgcctgggag aattgggcgc cattgacccc     4860

ggtcgcctgg acttcagcac aaccgagact caaggtaaag actttacctt cgtgaccgga     4920

gtcgaggatt cctccttcgc ttacggactg ctcatggaac tcactagagc ctacctggcc     4980

tatgctgaca actctcgcgc acaagattca gccgcttacg caatccaaga gctcctgtca     5040

atttacgact gccgtgagat ggaaacgaat ggtcccggtc accagctgtg gcgccgcttt     5100

ccagaacacg ttcgcgaaat cctggaaccc cacttgaaca ccagatacaa atccagccaa     5160

aagtctactg actggtccgg tgtgaagaag cctatttacc tgtccaaact gggcagcaat     5220

ttcgcagagt ggtccgctag ctgggcgggc tacctgatca ctaaagtgcg ccacgatctc     5280

gcaagcaaaa tcttcacttg ctgctccatt atgatgaagc atgacttcaa ggtgacaatt     5340

tatctgctcc cacacatcct ggtatacgtc ctgctgggct gtaaccagga agaccagcag     5400

gaggtatacg ctgagataat ggcagttttg aagcacgacg atcagcacac cattaacaca     5460

caggacattg cgtctgacct gtgtcaactg tccactcaaa ccgttttctc catgttggac     5520

catttgaccc agtgggcaag gcacaagttc caagccctca aagcagagaa atgccctcac     5580

agcaagagca atcgcaacaa ggttgactcc atggtttcta cagttgatta tgaggactat     5640

caatcagtta cacgctttct ggatctgatt ccacaagaca ctctggctgt ggcatctttc     5700

cgctctaagg cttacactag ggccgtgatg cacttcgaat cctttatcac cgagaaaaaa     5760

cagaacatcc aggagcactt gggtttcctc caaaagctgt acgccgccat gcacgagccg     5820

gacggcgtcg cgggtgtttc cgcaattcgc aaagctgagc cctccctgaa ggaacagatt     5880

ctggagcacg agtcactggg tctgctccgc gatgccacgg cgtgttacga tcgcgcgatt     5940

cagttggagc cagaccaaat catccactat catggtgtag taaagtccat gctgggactg     6000

ggtcagctct ctacggttat cactcaggta aacggagtgc atgcgaaccg ctccgaatgg     6060

accgatgagc tcaatactta cagggtggag gcagcgtgga agctcagcca gtgggacttg     6120

gtcgaaaatt acctggctgc ggatggcaag tccacaacgt ggtccgtgcg cctcggccag     6180

ctgctgctgt cagctaaaaa gagggatatt acggctttct acgactctct gaaactcgtc     6240

cgcgccgaac aaattgttcc gctgagcgcc gcgtctttcg aacgcggaag ctaccagaga     6300

ggatatgagt acatcgttcg cctgcacatg ttgtgcgagc tggagcactc tatcaaaccc     6360

ttgttccaac actccccggg tgattcatcc caagaggact ctctgaattg ggtcgctcgt     6420

ttggaaatga cccagaactc ctaccgcgcg aaggaaccta ttctggccct caggcgtgct     6480

ctgctgtcac tcaacaaacg cccggactac aatgagatgg tcggagaatg ttggctgcaa     6540

tcagctcgcg tggcgcgtaa agccggtcat catcaaactg cgtacaacgc tctgctgaac     6600

gccggcgaat cacgcttggc agaactctac gtagagcgcg caaaatggct gtggtccaag     6660

ggtgatgtgc accaggcgct catcgtcctg cagaagggag tggagctgtg tttccccgag     6720

aacgagacac caccggaagg aaagaacatg ctgatacatg gaagggctat gttgctggtg     6780

ggacgcttca tggaggaaac agcgaacttc gagtccaatg ctataatgaa gaagtacaaa     6840

gatgttacag cttgtctgcc cgaatgggag gacggtcact tctacttggc gaagtactat     6900

gataaattga tgcctatggt aaccgacaac aagatggaga agcaaggtga tctgatccgc     6960

tatatcgtgc tgcatttcgg tcgctcactg caatacggaa accagtttat ctaccaatcc     7020

atgccacgta tgttgaccct gtggctggat tacggtacca aagcttacga gtgggaaaaa     7080

gcgggcagga gcgacagagt gcagatgaga aatgacctgg gtaaaatcaa caaagtcata     7140

actgaacata ccaactacct cgcgccgtat cagtttctga ctgctttcag ccaactcatc     7200

tcacgcatct gtcacagcca cgacgaggtt ttcgtggtcc tgatggaaat catcgcaaaa     7260

gtgttcctgg cctatcctca acaggccatg tggatgatga cggctgtgtc caagtcttca     7320

taccccatgc gcgttaaccg ttgtaaggaa atcctgaaca aggctatcca catgaagaaa     7380

agcctggaga agtttgtcgg tgacgctacg agactgaccg acaagttgct ggaattgtgc     7440

aacaagcctg tggatggaag ctccagcact ctgtctatga gcacgcactt caagatgctg     7500

aagaagctgg tagaagaggc cacgttttcc gaaatcctga tacccctgca gtccgtgatg     7560

atccctacct tgccttccat cctgggaacc cacgctaacc acgcctctca tgaacccttc     7620

cccggacact gggcctatat cgctggattt gacgatatgg tcgaaattct ggcatccctg     7680

cagaagccca aaaagatctc actgaagggt tccgacggta agttctacat aatgatgtgc     7740

aagcctaagg atgacctcag aaaggactgc cgtctgatgg agttcaactc cctgattaac     7800

aaatgtctca gaaaggacgc tgagagccgt cgcagggagc tgcacattcg tacatacgca     7860

gtgatccctc tgaacgatga gtgtggcatc atagagtggg tcaataacac tgcgggactc     7920

cgcccgattc tgacaaaact ctacaaagag aagggtgtct atatgacagg taaagagttg     7980

cgccaatgta tgctccctaa atccgctgcc ctctccgaga agttgaaggt tttcagagaa     8040

ttcctcctgc caaggcaccc accaattttc cacgaatggt ttctgcgcac attccccgac     8100

cctacgtcct ggtattcttc ccgctccgcc tactgtcgtt caactgcagt aatgagcatg     8160

gttggttaca tcctcggtct gggcgaccgc cacggagaga acatcctgtt cgactccctg     8220

accggcgagt gcgtgcacgt ggatttcaat tgcttgttca ataagggtga aactttcgaa     8280

gtacctgaaa tagtgccttt ccgcctgaca cataacatgg tcaatggcat gggaccaatg     8340

ggcacggaag gactgttcag aagagcctgc gaggtcacca tgcgcctgat gcgcgatcag     8400

cgcgagccgc tgatgtcagt actcaagacg tttctgcatg accctctcgt ggagtggtcc     8460

aagcccgtca aaggccatag caaagcgcct ctgaacgaga ctggagaggt agtgaacgag     8520

aaggctaaaa cgcacgtcct cgatatagaa cagaggctgc aaggtgtgat caagacaaga     8580

aatcgtgtca cgggtctgcc tctgtccatt gaaggccacg tccactacct gatccaggag     8640

gccacagacg aaaatctgct ctgccaaatg tacctgggat ggacaccata catgtaa        8697


<210> 2
<211> 2493
<212> DNA
<213> synthetic organisms

<220> 
<223> Codon-optimized ATRIP including STREP tag

<400> 2
atggccagct ggagccaccc tcagttcgaa aagagcgcgg gcctcgagac aagtttgtac      60

aaaaaagcag gctccgatta tgacattcca acgaccgaaa atctgtactt tcagggcatg     120

gctggtacct ctgccccagg tagcaagagg agatcagaac ctcctgcacc aaggcccggt     180

ccacctcccg gtactggaca tccaccctct aagcgcgcca gaggctttag cgctgccgcg     240

gcacctgatc ctgatgaccc ttttggtgct cacggtgact ttacagcaga cgatctggag     300

gagctcgaca ctttggcgtc ccaggcactg tcacaatgcc ccgcagccgc tcgcgacgtt     360

tcatccgacc acaaagtgca ccgtttgctc gacggaatgt ctaagaaccc ctccggaaaa     420

aacagggaaa ccgtccctat caaagacaac ttcgagctgg aggtgttgca agcccagtac     480

aaagagctga aggagaagat gaaggtgatg gaggaagagg tcctgatcaa gaacggcgag     540

atcaagattc tgcgcgattc cctgcaccag acggaaagcg tcctggaaga gcagaggcgt     600

tcccactttc tgctggagca ggaaaaaacg caggctctgt ccgacaagga gaaggagttc     660

agcaagaagc tgcaaagctt gcaaagcgaa ctccagttca aagatgctga aatgaatgaa     720

ctccgtacaa agctgcagac cagcgagaga gctaataagc tcgctgcacc gagtgtgtca     780

cacgtatccc cgcgcaagaa tccgagtgta gttatcaagc ctgaagcctg ttctccacaa     840

ttcggcaaaa catccttccc gacaaaggag tccttctccg ccaacatgtc tctgcctcac     900

ccttgtcaga ccgagtcagg ctacaaaccg ctggtcggta gagaggatag taagccccac     960

tctctgcgcg gagattccat aaagcaggag gaagcccaga agtccttcgt cgattcttgg    1020

cgtcaaagga gcaataccca gggttctatc ctcattaact tgctcctgaa gcaacctttg    1080

atccccggct cttccctctc cctgtgtcat ctgctgtcca gctcttccga gtccccagct    1140

ggcacaccgc tgcaacctcc cggcttcggc tccactctcg cgggcatgtc aggactgagg    1200

acgaccggca gctatgacgg ttccttctct ctctccgcct tgcgcgaagc gcagaacttg    1260

gcattcacgg gattgaacct ggttgctagg aacgagtgct cacgtgacgg agatccagcc    1320

gaaggtggac gcagagcctt tcctttgtgc caactgcccg gtgctgttca cttcttgcca    1380

ctggtgcagt tcttcatcgg tttgcactgt caagctctgc aggatctggc ggccgctaaa    1440

agatccggtg ctccgggtga ctcacccact catagctcat gcgtctcttc cggtgtggaa    1500

acgaatccgg aggatagtgt atgcattctg gagggtttct cagttaccgc gctctccatt    1560

ctgcagcacc tggtgtgcca ttcaggcgcc gttgtcagtc tcctgctgtc tggagtcgga    1620

gcggactcag ccgcgggtga gggtaaccgc tccctcgtcc atcgcctgtc tgacggcgac    1680

atgaccagcg ctttgcgtgg agtcgcagat gaccaaggtc agcatcccct cttgaagatg    1740

ctgctgcatc tgttggcatt ttcctccgca gctactggtc acctccaagc cagcgtgttg    1800

acccagtgtc tcaaagtgct ggtcaaactg gcggagaaca caagttgcga cttcttgcct    1860

cgcttccaat gcgtgttcca agtactccct aagtgcttgt caccagaaac accgctgcca    1920

agtgtgctcc tggccgttga actgctgagt ctgctggctg accacgacca actggctccc    1980

cagctgtgca gtcacagtga aggttgtctg ctgctcctgc tctacatgta catcacgtca    2040

cgtcccgacc gtgtggcctt ggagactcaa tggttgcagc tggaacagga ggtcgtgtgg    2100

ctcctggcga aactgggagt gcagagtcca ctgccaccag ttacaggaag caactgtcag    2160

tgcaacgtag aggtggtgag agctctgaca gtcatgttgc atcgccaatg gctcactgta    2220

cgcagggcag gcggtccacc ccgtaccgat caacagcgcc gcaccgtaag atgtctgcgc    2280

gacactgttc tgctgctgca tggactgagc caaaaggaca aactgttcat gatgcactgc    2340

gtggaagtgc tgcaccagtt cgaccaagtc atgcccggcg tatccatgct catacgtgga    2400

ctgcccgatg taactgactg cgaggaagct gccctggacg atctgtgtgc tgcggaaact    2460

gacgtcgaag atcctgaggt tgaatgcggc taa                                 2493


<210> 3
<211> 2898
<212> PRT
<213> synthetic organisms

<400> 3
Met Ala Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln 
1               5                   10                  15      
Pro Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His 
            20                  25                  30          
Leu Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu 
        35                  40                  45              
Leu Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val 
    50                  55                  60                  
Lys Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His 
65                  70                  75                  80  
Asn Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu 
                85                  90                  95      
Glu Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr 
            100                 105                 110         
Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro 
        115                 120                 125             
Glu Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu 
    130                 135                 140                 
Asn Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu 
145                 150                 155                 160 
Asp Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys 
                165                 170                 175     
Leu Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys 
            180                 185                 190         
Tyr Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln 
        195                 200                 205             
Ala Thr Phe Gly Gly Gly Asp His Pro Pro Lys Ser Asp Gln Ile Thr 
    210                 215                 220                 
Ser Leu Tyr Lys Lys Ala Gly Ser Asp Tyr Asp Ile Pro Thr Thr Glu 
225                 230                 235                 240 
Asn Leu Tyr Phe Gln Gly Asp Tyr Lys Asp Asp Asp Asp Lys Met Gly 
                245                 250                 255     
Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg Glu Leu 
            260                 265                 270         
Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys Pro Arg 
        275                 280                 285             
Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val Asn Val 
    290                 295                 300                 
Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr Ser Val 
305                 310                 315                 320 
Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro Leu Met 
                325                 330                 335     
Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys Ile Glu 
            340                 345                 350         
Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala Thr Pro 
        355                 360                 365             
Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys Ser Leu 
    370                 375                 380                 
Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val Leu Thr 
385                 390                 395                 400 
Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His Arg Arg 
                405                 410                 415     
Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser Arg Phe 
            420                 425                 430         
Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala Pro Leu 
        435                 440                 445             
Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr Leu Leu 
    450                 455                 460                 
Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg Gln Glu 
465                 470                 475                 480 
Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly Ser Pro 
                485                 490                 495     
Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe Gln Leu 
            500                 505                 510         
Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser Phe Leu 
        515                 520                 525             
Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu Lys Leu 
    530                 535                 540                 
Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro Phe Glu 
545                 550                 555                 560 
Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met Leu Leu 
                565                 570                 575     
Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg Leu Lys 
            580                 585                 590         
Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr Phe Leu 
        595                 600                 605             
Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg Lys Val 
    610                 615                 620                 
Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly Ile Glu 
625                 630                 635                 640 
Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu Lys Met 
                645                 650                 655     
Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln Gln Glu 
            660                 665                 670         
Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg Arg Leu 
        675                 680                 685             
Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr Glu Glu 
    690                 695                 700                 
Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser Ala Leu 
705                 710                 715                 720 
Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser Gly Leu 
                725                 730                 735     
Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val Leu Gln 
            740                 745                 750         
Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met Asn Cys 
        755                 760                 765             
Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro Ser Val 
    770                 775                 780                 
Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu Lys Ser 
785                 790                 795                 800 
Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu Ala Thr 
                805                 810                 815     
Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met Gln Val 
            820                 825                 830         
Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly Met Leu 
        835                 840                 845             
Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu Lys Leu 
    850                 855                 860                 
Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile Ser Asp 
865                 870                 875                 880 
Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu Thr Leu 
                885                 890                 895     
Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr Asn Trp 
            900                 905                 910         
Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val Ser Gly 
        915                 920                 925             
Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val Pro Lys 
    930                 935                 940                 
Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys Lys Glu 
945                 950                 955                 960 
Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly Met Phe 
                965                 970                 975     
Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly His Val 
            980                 985                 990         
Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu Cys Ser 
        995                 1000                1005            
Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe Leu Leu 
    1010                1015                1020                
Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp Asn Leu 
1025                1030                1035                1040
His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr Asp Val 
                1045                1050                1055    
Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro Asp Lys 
            1060                1065                1070        
Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu Glu Ser 
        1075                1080                1085            
Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu Arg Met 
    1090                1095                1100                
Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu Leu Lys 
1105                1110                1115                1120
Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala Lys Gly 
                1125                1130                1135    
Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu Leu Ser 
            1140                1145                1150        
Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg Ala Leu 
        1155                1160                1165            
Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln Tyr Lys 
    1170                1175                1180                
Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser Gln Met 
1185                1190                1195                1200
Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg Lys Gln 
                1205                1210                1215    
Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser Glu Ile 
            1220                1225                1230        
Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr Arg Thr 
        1235                1240                1245            
Leu Gln Val Leu Leu Pro Asp Leu Ala Ala Lys Ala Ser Pro Ala Ala 
    1250                1255                1260                
Ser Ala Leu Ile Arg Thr Leu Gly Lys Gln Leu Asn Val Asn Arg Arg 
1265                1270                1275                1280
Glu Ile Leu Ile Asn Asn Phe Lys Tyr Ile Phe Ser His Leu Val Cys 
                1285                1290                1295    
Ser Cys Ser Lys Asp Glu Leu Glu Arg Ala Leu His Tyr Leu Lys Asn 
            1300                1305                1310        
Glu Thr Glu Ile Glu Leu Gly Ser Leu Leu Arg Gln Asp Phe Gln Gly 
        1315                1320                1325            
Leu His Asn Glu Leu Leu Leu Arg Ile Gly Glu His Tyr Gln Gln Val 
    1330                1335                1340                
Phe Asn Gly Leu Ser Ile Leu Ala Ser Phe Ala Ser Ser Asp Asp Pro 
1345                1350                1355                1360
Tyr Gln Gly Pro Arg Asp Ile Ile Ser Pro Glu Leu Met Ala Asp Tyr 
                1365                1370                1375    
Leu Gln Pro Lys Leu Leu Gly Ile Leu Ala Phe Phe Asn Met Gln Leu 
            1380                1385                1390        
Leu Ser Ser Ser Val Gly Ile Glu Asp Lys Lys Met Ala Leu Asn Ser 
        1395                1400                1405            
Leu Met Ser Leu Met Lys Leu Met Gly Pro Lys His Val Ser Ser Val 
    1410                1415                1420                
Arg Val Lys Met Met Thr Thr Leu Arg Thr Gly Leu Arg Phe Lys Asp 
1425                1430                1435                1440
Asp Phe Pro Glu Leu Cys Cys Arg Ala Trp Asp Cys Phe Val Arg Cys 
                1445                1450                1455    
Leu Asp His Ala Cys Leu Gly Ser Leu Leu Ser His Val Ile Val Ala 
            1460                1465                1470        
Leu Leu Pro Leu Ile His Ile Gln Pro Lys Glu Thr Ala Ala Ile Phe 
        1475                1480                1485            
His Tyr Leu Ile Ile Glu Asn Arg Asp Ala Val Gln Asp Phe Leu His 
    1490                1495                1500                
Glu Ile Tyr Phe Leu Pro Asp His Pro Glu Leu Lys Lys Ile Lys Ala 
1505                1510                1515                1520
Val Leu Gln Glu Tyr Arg Lys Glu Thr Ser Glu Ser Thr Asp Leu Gln 
                1525                1530                1535    
Thr Thr Leu Gln Leu Ser Met Lys Ala Ile Gln His Glu Asn Val Asp 
            1540                1545                1550        
Val Arg Ile His Ala Leu Thr Ser Leu Lys Glu Thr Leu Tyr Lys Asn 
        1555                1560                1565            
Gln Glu Lys Leu Ile Lys Tyr Ala Thr Asp Ser Glu Thr Val Glu Pro 
    1570                1575                1580                
Ile Ile Ser Gln Leu Val Thr Val Leu Leu Lys Gly Cys Gln Asp Ala 
1585                1590                1595                1600
Asn Ser Gln Ala Arg Leu Leu Cys Gly Glu Cys Leu Gly Glu Leu Gly 
                1605                1610                1615    
Ala Ile Asp Pro Gly Arg Leu Asp Phe Ser Thr Thr Glu Thr Gln Gly 
            1620                1625                1630        
Lys Asp Phe Thr Phe Val Thr Gly Val Glu Asp Ser Ser Phe Ala Tyr 
        1635                1640                1645            
Gly Leu Leu Met Glu Leu Thr Arg Ala Tyr Leu Ala Tyr Ala Asp Asn 
    1650                1655                1660                
Ser Arg Ala Gln Asp Ser Ala Ala Tyr Ala Ile Gln Glu Leu Leu Ser 
1665                1670                1675                1680
Ile Tyr Asp Cys Arg Glu Met Glu Thr Asn Gly Pro Gly His Gln Leu 
                1685                1690                1695    
Trp Arg Arg Phe Pro Glu His Val Arg Glu Ile Leu Glu Pro His Leu 
            1700                1705                1710        
Asn Thr Arg Tyr Lys Ser Ser Gln Lys Ser Thr Asp Trp Ser Gly Val 
        1715                1720                1725            
Lys Lys Pro Ile Tyr Leu Ser Lys Leu Gly Ser Asn Phe Ala Glu Trp 
    1730                1735                1740                
Ser Ala Ser Trp Ala Gly Tyr Leu Ile Thr Lys Val Arg His Asp Leu 
1745                1750                1755                1760
Ala Ser Lys Ile Phe Thr Cys Cys Ser Ile Met Met Lys His Asp Phe 
                1765                1770                1775    
Lys Val Thr Ile Tyr Leu Leu Pro His Ile Leu Val Tyr Val Leu Leu 
            1780                1785                1790        
Gly Cys Asn Gln Glu Asp Gln Gln Glu Val Tyr Ala Glu Ile Met Ala 
        1795                1800                1805            
Val Leu Lys His Asp Asp Gln His Thr Ile Asn Thr Gln Asp Ile Ala 
    1810                1815                1820                
Ser Asp Leu Cys Gln Leu Ser Thr Gln Thr Val Phe Ser Met Leu Asp 
1825                1830                1835                1840
His Leu Thr Gln Trp Ala Arg His Lys Phe Gln Ala Leu Lys Ala Glu 
                1845                1850                1855    
Lys Cys Pro His Ser Lys Ser Asn Arg Asn Lys Val Asp Ser Met Val 
            1860                1865                1870        
Ser Thr Val Asp Tyr Glu Asp Tyr Gln Ser Val Thr Arg Phe Leu Asp 
        1875                1880                1885            
Leu Ile Pro Gln Asp Thr Leu Ala Val Ala Ser Phe Arg Ser Lys Ala 
    1890                1895                1900                
Tyr Thr Arg Ala Val Met His Phe Glu Ser Phe Ile Thr Glu Lys Lys 
1905                1910                1915                1920
Gln Asn Ile Gln Glu His Leu Gly Phe Leu Gln Lys Leu Tyr Ala Ala 
                1925                1930                1935    
Met His Glu Pro Asp Gly Val Ala Gly Val Ser Ala Ile Arg Lys Ala 
            1940                1945                1950        
Glu Pro Ser Leu Lys Glu Gln Ile Leu Glu His Glu Ser Leu Gly Leu 
        1955                1960                1965            
Leu Arg Asp Ala Thr Ala Cys Tyr Asp Arg Ala Ile Gln Leu Glu Pro 
    1970                1975                1980                
Asp Gln Ile Ile His Tyr His Gly Val Val Lys Ser Met Leu Gly Leu 
1985                1990                1995                2000
Gly Gln Leu Ser Thr Val Ile Thr Gln Val Asn Gly Val His Ala Asn 
                2005                2010                2015    
Arg Ser Glu Trp Thr Asp Glu Leu Asn Thr Tyr Arg Val Glu Ala Ala 
            2020                2025                2030        
Trp Lys Leu Ser Gln Trp Asp Leu Val Glu Asn Tyr Leu Ala Ala Asp 
        2035                2040                2045            
Gly Lys Ser Thr Thr Trp Ser Val Arg Leu Gly Gln Leu Leu Leu Ser 
    2050                2055                2060                
Ala Lys Lys Arg Asp Ile Thr Ala Phe Tyr Asp Ser Leu Lys Leu Val 
2065                2070                2075                2080
Arg Ala Glu Gln Ile Val Pro Leu Ser Ala Ala Ser Phe Glu Arg Gly 
                2085                2090                2095    
Ser Tyr Gln Arg Gly Tyr Glu Tyr Ile Val Arg Leu His Met Leu Cys 
            2100                2105                2110        
Glu Leu Glu His Ser Ile Lys Pro Leu Phe Gln His Ser Pro Gly Asp 
        2115                2120                2125            
Ser Ser Gln Glu Asp Ser Leu Asn Trp Val Ala Arg Leu Glu Met Thr 
    2130                2135                2140                
Gln Asn Ser Tyr Arg Ala Lys Glu Pro Ile Leu Ala Leu Arg Arg Ala 
2145                2150                2155                2160
Leu Leu Ser Leu Asn Lys Arg Pro Asp Tyr Asn Glu Met Val Gly Glu 
                2165                2170                2175    
Cys Trp Leu Gln Ser Ala Arg Val Ala Arg Lys Ala Gly His His Gln 
            2180                2185                2190        
Thr Ala Tyr Asn Ala Leu Leu Asn Ala Gly Glu Ser Arg Leu Ala Glu 
        2195                2200                2205            
Leu Tyr Val Glu Arg Ala Lys Trp Leu Trp Ser Lys Gly Asp Val His 
    2210                2215                2220                
Gln Ala Leu Ile Val Leu Gln Lys Gly Val Glu Leu Cys Phe Pro Glu 
2225                2230                2235                2240
Asn Glu Thr Pro Pro Glu Gly Lys Asn Met Leu Ile His Gly Arg Ala 
                2245                2250                2255    
Met Leu Leu Val Gly Arg Phe Met Glu Glu Thr Ala Asn Phe Glu Ser 
            2260                2265                2270        
Asn Ala Ile Met Lys Lys Tyr Lys Asp Val Thr Ala Cys Leu Pro Glu 
        2275                2280                2285            
Trp Glu Asp Gly His Phe Tyr Leu Ala Lys Tyr Tyr Asp Lys Leu Met 
    2290                2295                2300                
Pro Met Val Thr Asp Asn Lys Met Glu Lys Gln Gly Asp Leu Ile Arg 
2305                2310                2315                2320
Tyr Ile Val Leu His Phe Gly Arg Ser Leu Gln Tyr Gly Asn Gln Phe 
                2325                2330                2335    
Ile Tyr Gln Ser Met Pro Arg Met Leu Thr Leu Trp Leu Asp Tyr Gly 
            2340                2345                2350        
Thr Lys Ala Tyr Glu Trp Glu Lys Ala Gly Arg Ser Asp Arg Val Gln 
        2355                2360                2365            
Met Arg Asn Asp Leu Gly Lys Ile Asn Lys Val Ile Thr Glu His Thr 
    2370                2375                2380                
Asn Tyr Leu Ala Pro Tyr Gln Phe Leu Thr Ala Phe Ser Gln Leu Ile 
2385                2390                2395                2400
Ser Arg Ile Cys His Ser His Asp Glu Val Phe Val Val Leu Met Glu 
                2405                2410                2415    
Ile Ile Ala Lys Val Phe Leu Ala Tyr Pro Gln Gln Ala Met Trp Met 
            2420                2425                2430        
Met Thr Ala Val Ser Lys Ser Ser Tyr Pro Met Arg Val Asn Arg Cys 
        2435                2440                2445            
Lys Glu Ile Leu Asn Lys Ala Ile His Met Lys Lys Ser Leu Glu Lys 
    2450                2455                2460                
Phe Val Gly Asp Ala Thr Arg Leu Thr Asp Lys Leu Leu Glu Leu Cys 
2465                2470                2475                2480
Asn Lys Pro Val Asp Gly Ser Ser Ser Thr Leu Ser Met Ser Thr His 
                2485                2490                2495    
Phe Lys Met Leu Lys Lys Leu Val Glu Glu Ala Thr Phe Ser Glu Ile 
            2500                2505                2510        
Leu Ile Pro Leu Gln Ser Val Met Ile Pro Thr Leu Pro Ser Ile Leu 
        2515                2520                2525            
Gly Thr His Ala Asn His Ala Ser His Glu Pro Phe Pro Gly His Trp 
    2530                2535                2540                
Ala Tyr Ile Ala Gly Phe Asp Asp Met Val Glu Ile Leu Ala Ser Leu 
2545                2550                2555                2560
Gln Lys Pro Lys Lys Ile Ser Leu Lys Gly Ser Asp Gly Lys Phe Tyr 
                2565                2570                2575    
Ile Met Met Cys Lys Pro Lys Asp Asp Leu Arg Lys Asp Cys Arg Leu 
            2580                2585                2590        
Met Glu Phe Asn Ser Leu Ile Asn Lys Cys Leu Arg Lys Asp Ala Glu 
        2595                2600                2605            
Ser Arg Arg Arg Glu Leu His Ile Arg Thr Tyr Ala Val Ile Pro Leu 
    2610                2615                2620                
Asn Asp Glu Cys Gly Ile Ile Glu Trp Val Asn Asn Thr Ala Gly Leu 
2625                2630                2635                2640
Arg Pro Ile Leu Thr Lys Leu Tyr Lys Glu Lys Gly Val Tyr Met Thr 
                2645                2650                2655    
Gly Lys Glu Leu Arg Gln Cys Met Leu Pro Lys Ser Ala Ala Leu Ser 
            2660                2665                2670        
Glu Lys Leu Lys Val Phe Arg Glu Phe Leu Leu Pro Arg His Pro Pro 
        2675                2680                2685            
Ile Phe His Glu Trp Phe Leu Arg Thr Phe Pro Asp Pro Thr Ser Trp 
    2690                2695                2700                
Tyr Ser Ser Arg Ser Ala Tyr Cys Arg Ser Thr Ala Val Met Ser Met 
2705                2710                2715                2720
Val Gly Tyr Ile Leu Gly Leu Gly Asp Arg His Gly Glu Asn Ile Leu 
                2725                2730                2735    
Phe Asp Ser Leu Thr Gly Glu Cys Val His Val Asp Phe Asn Cys Leu 
            2740                2745                2750        
Phe Asn Lys Gly Glu Thr Phe Glu Val Pro Glu Ile Val Pro Phe Arg 
        2755                2760                2765            
Leu Thr His Asn Met Val Asn Gly Met Gly Pro Met Gly Thr Glu Gly 
    2770                2775                2780                
Leu Phe Arg Arg Ala Cys Glu Val Thr Met Arg Leu Met Arg Asp Gln 
2785                2790                2795                2800
Arg Glu Pro Leu Met Ser Val Leu Lys Thr Phe Leu His Asp Pro Leu 
                2805                2810                2815    
Val Glu Trp Ser Lys Pro Val Lys Gly His Ser Lys Ala Pro Leu Asn 
            2820                2825                2830        
Glu Thr Gly Glu Val Val Asn Glu Lys Ala Lys Thr His Val Leu Asp 
        2835                2840                2845            
Ile Glu Gln Arg Leu Gln Gly Val Ile Lys Thr Arg Asn Arg Val Thr 
    2850                2855                2860                
Gly Leu Pro Leu Ser Ile Glu Gly His Val His Tyr Leu Ile Gln Glu 
2865                2870                2875                2880
Ala Thr Asp Glu Asn Leu Leu Cys Gln Met Tyr Leu Gly Trp Thr Pro 
                2885                2890                2895    
Tyr Met 
        

<210> 4
<211> 830
<212> PRT
<213> synthetic organisms

<400> 4
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Ser Ala Gly Leu Glu 
1               5                   10                  15      
Thr Ser Leu Tyr Lys Lys Ala Gly Ser Asp Tyr Asp Ile Pro Thr Thr 
            20                  25                  30          
Glu Asn Leu Tyr Phe Gln Gly Met Ala Gly Thr Ser Ala Pro Gly Ser 
        35                  40                  45              
Lys Arg Arg Ser Glu Pro Pro Ala Pro Arg Pro Gly Pro Pro Pro Gly 
    50                  55                  60                  
Thr Gly His Pro Pro Ser Lys Arg Ala Arg Gly Phe Ser Ala Ala Ala 
65                  70                  75                  80  
Ala Pro Asp Pro Asp Asp Pro Phe Gly Ala His Gly Asp Phe Thr Ala 
                85                  90                  95      
Asp Asp Leu Glu Glu Leu Asp Thr Leu Ala Ser Gln Ala Leu Ser Gln 
            100                 105                 110         
Cys Pro Ala Ala Ala Arg Asp Val Ser Ser Asp His Lys Val His Arg 
        115                 120                 125             
Leu Leu Asp Gly Met Ser Lys Asn Pro Ser Gly Lys Asn Arg Glu Thr 
    130                 135                 140                 
Val Pro Ile Lys Asp Asn Phe Glu Leu Glu Val Leu Gln Ala Gln Tyr 
145                 150                 155                 160 
Lys Glu Leu Lys Glu Lys Met Lys Val Met Glu Glu Glu Val Leu Ile 
                165                 170                 175     
Lys Asn Gly Glu Ile Lys Ile Leu Arg Asp Ser Leu His Gln Thr Glu 
            180                 185                 190         
Ser Val Leu Glu Glu Gln Arg Arg Ser His Phe Leu Leu Glu Gln Glu 
        195                 200                 205             
Lys Thr Gln Ala Leu Ser Asp Lys Glu Lys Glu Phe Ser Lys Lys Leu 
    210                 215                 220                 
Gln Ser Leu Gln Ser Glu Leu Gln Phe Lys Asp Ala Glu Met Asn Glu 
225                 230                 235                 240 
Leu Arg Thr Lys Leu Gln Thr Ser Glu Arg Ala Asn Lys Leu Ala Ala 
                245                 250                 255     
Pro Ser Val Ser His Val Ser Pro Arg Lys Asn Pro Ser Val Val Ile 
            260                 265                 270         
Lys Pro Glu Ala Cys Ser Pro Gln Phe Gly Lys Thr Ser Phe Pro Thr 
        275                 280                 285             
Lys Glu Ser Phe Ser Ala Asn Met Ser Leu Pro His Pro Cys Gln Thr 
    290                 295                 300                 
Glu Ser Gly Tyr Lys Pro Leu Val Gly Arg Glu Asp Ser Lys Pro His 
305                 310                 315                 320 
Ser Leu Arg Gly Asp Ser Ile Lys Gln Glu Glu Ala Gln Lys Ser Phe 
                325                 330                 335     
Val Asp Ser Trp Arg Gln Arg Ser Asn Thr Gln Gly Ser Ile Leu Ile 
            340                 345                 350         
Asn Leu Leu Leu Lys Gln Pro Leu Ile Pro Gly Ser Ser Leu Ser Leu 
        355                 360                 365             
Cys His Leu Leu Ser Ser Ser Ser Glu Ser Pro Ala Gly Thr Pro Leu 
    370                 375                 380                 
Gln Pro Pro Gly Phe Gly Ser Thr Leu Ala Gly Met Ser Gly Leu Arg 
385                 390                 395                 400 
Thr Thr Gly Ser Tyr Asp Gly Ser Phe Ser Leu Ser Ala Leu Arg Glu 
                405                 410                 415     
Ala Gln Asn Leu Ala Phe Thr Gly Leu Asn Leu Val Ala Arg Asn Glu 
            420                 425                 430         
Cys Ser Arg Asp Gly Asp Pro Ala Glu Gly Gly Arg Arg Ala Phe Pro 
        435                 440                 445             
Leu Cys Gln Leu Pro Gly Ala Val His Phe Leu Pro Leu Val Gln Phe 
    450                 455                 460                 
Phe Ile Gly Leu His Cys Gln Ala Leu Gln Asp Leu Ala Ala Ala Lys 
465                 470                 475                 480 
Arg Ser Gly Ala Pro Gly Asp Ser Pro Thr His Ser Ser Cys Val Ser 
                485                 490                 495     
Ser Gly Val Glu Thr Asn Pro Glu Asp Ser Val Cys Ile Leu Glu Gly 
            500                 505                 510         
Phe Ser Val Thr Ala Leu Ser Ile Leu Gln His Leu Val Cys His Ser 
        515                 520                 525             
Gly Ala Val Val Ser Leu Leu Leu Ser Gly Val Gly Ala Asp Ser Ala 
    530                 535                 540                 
Ala Gly Glu Gly Asn Arg Ser Leu Val His Arg Leu Ser Asp Gly Asp 
545                 550                 555                 560 
Met Thr Ser Ala Leu Arg Gly Val Ala Asp Asp Gln Gly Gln His Pro 
                565                 570                 575     
Leu Leu Lys Met Leu Leu His Leu Leu Ala Phe Ser Ser Ala Ala Thr 
            580                 585                 590         
Gly His Leu Gln Ala Ser Val Leu Thr Gln Cys Leu Lys Val Leu Val 
        595                 600                 605             
Lys Leu Ala Glu Asn Thr Ser Cys Asp Phe Leu Pro Arg Phe Gln Cys 
    610                 615                 620                 
Val Phe Gln Val Leu Pro Lys Cys Leu Ser Pro Glu Thr Pro Leu Pro 
625                 630                 635                 640 
Ser Val Leu Leu Ala Val Glu Leu Leu Ser Leu Leu Ala Asp His Asp 
                645                 650                 655     
Gln Leu Ala Pro Gln Leu Cys Ser His Ser Glu Gly Cys Leu Leu Leu 
            660                 665                 670         
Leu Leu Tyr Met Tyr Ile Thr Ser Arg Pro Asp Arg Val Ala Leu Glu 
        675                 680                 685             
Thr Gln Trp Leu Gln Leu Glu Gln Glu Val Val Trp Leu Leu Ala Lys 
    690                 695                 700                 
Leu Gly Val Gln Ser Pro Leu Pro Pro Val Thr Gly Ser Asn Cys Gln 
705                 710                 715                 720 
Cys Asn Val Glu Val Val Arg Ala Leu Thr Val Met Leu His Arg Gln 
                725                 730                 735     
Trp Leu Thr Val Arg Arg Ala Gly Gly Pro Pro Arg Thr Asp Gln Gln 
            740                 745                 750         
Arg Arg Thr Val Arg Cys Leu Arg Asp Thr Val Leu Leu Leu His Gly 
        755                 760                 765             
Leu Ser Gln Lys Asp Lys Leu Phe Met Met His Cys Val Glu Val Leu 
    770                 775                 780                 
His Gln Phe Asp Gln Val Met Pro Gly Val Ser Met Leu Ile Arg Gly 
785                 790                 795                 800 
Leu Pro Asp Val Thr Asp Cys Glu Glu Ala Ala Leu Asp Asp Leu Cys 
                805                 810                 815     
Ala Ala Glu Thr Asp Val Glu Asp Pro Glu Val Glu Cys Gly 
            820                 825                 830 

