                         SEQUENCE LISTING

<110>  AFFiRiS AG
 
<120>  Alpha chain of the high-affinity IgE receptor (FceRIa)

<130>  R 70258

<150>  EP16020009.3
<151>  2016-01-13

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  2
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant


<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  amino acid selected from A, I, L, N, D, M, F, E, T, Q, W, G and V

<400>  2

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Xaa Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  3
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant

<400>  3

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Ala Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val Ser Ser Thr Lys Trp 
    50                  55                  60                  


Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn Ile 
65                  70                  75                  80  


Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys Cys Gln His Gln 
                85                  90                  95      


Gln Val Asn Glu Ser Glu Pro Val Tyr Leu Glu Val Phe Ser Asp Trp 
            100                 105                 110         


Leu Leu Leu Gln Ala Ser Ala Glu Val Val Met Glu Gly Gln Pro Leu 
        115                 120                 125             


Phe Leu Arg Cys His Gly Trp Arg Asn Trp Asp Val Tyr Lys Val Ile 
    130                 135                 140                 


Tyr Tyr Lys Asp Gly Glu Ala Leu Lys Tyr Trp Tyr Glu Asn His Asn 
145                 150                 155                 160 


Ile Ser Ile Thr Asn Ala Thr Val Glu Asp Ser Gly Thr Tyr Tyr Cys 
                165                 170                 175     


Thr Gly Lys Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile 
            180                 185                 190         


Thr Val Ile Lys Ala Pro Arg Glu Lys Tyr Trp Leu Gln Phe Phe Ile 
        195                 200                 205             


Pro Leu Leu Val Val Ile Leu Phe Ala Val Asp Thr Gly Leu Phe Ile 
    210                 215                 220                 


Ser Thr Gln Gln Gln Val Thr Phe Leu Leu Lys Ile Lys Arg Thr Arg 
225                 230                 235                 240 


Lys Gly Phe Arg Leu Leu Asn Pro His Pro Lys Pro Asn Pro Lys Asn 
                245                 250                 255     


Asn 
    


<210>  4
<211>  35
<212>  PRT
<213>  Sus scrofa scrofa

<400>  4

Ala Val Ile Gln Glu Ser Gln Val Ser Leu Asn Pro Pro Trp Asn Arg 
1               5                   10                  15      


Ile Phe Arg Gly Glu Asn Val Thr Leu Thr Cys Ile Gly Asn Tyr Ser 
            20                  25                  30          


Leu Glu Asn 
        35  


<210>  5
<211>  36
<212>  PRT
<213>  Otolemur garnettii

<400>  5

Leu Glu Ala Ile Arg Gln Ser Ile Leu Ser Leu Asn Pro Gln Trp Asn 
1               5                   10                  15      


Arg Ile Phe Lys Gly Glu Asn Val Thr Leu Leu Cys Asn Arg Asp Asn 
            20                  25                  30          


Phe Phe Glu Val 
        35      


<210>  6
<211>  49
<212>  PRT
<213>  Mus musculus

<400>  6

Leu Cys Leu Ala Leu Leu Phe Met Ser Leu Asp Val Ile Leu Thr Ala 
1               5                   10                  15      


Thr Glu Lys Ser Val Leu Thr Leu Asp Pro Pro Trp Ile Arg Ile Phe 
            20                  25                  30          


Thr Gly Glu Lys Val Thr Leu Ser Cys Tyr Gly Asn Asn His Leu Gln 
        35                  40                  45              


Met 
    


<210>  7
<211>  49
<212>  PRT
<213>  rattus norwegicus

<400>  7

Leu Cys Leu Ala Leu Val Leu Ile Ser Leu Gly Val Met Leu Thr Ala 
1               5                   10                  15      


Thr Gln Lys Ser Val Val Ser Leu Asp Pro Pro Trp Ile Arg Ile Leu 
            20                  25                  30          


Thr Gly Asp Lys Val Thr Leu Ile Cys Asn Gly Asn Asn Ser Ser Gln 
        35                  40                  45              


Met 
    


<210>  8
<211>  59
<212>  PRT
<213>  Canis lupus familiaris

<400>  8

Met Pro Ala Ser Met Gly Gly Pro Ala Leu Leu Trp Leu Ala Leu Leu 
1               5                   10                  15      


Leu Ser Ser Pro Gly Val Met Ser Ser Asp Thr Leu Lys Pro Thr Val 
            20                  25                  30          


Ser Met Asn Pro Pro Trp Asn Thr Ile Leu Lys Asp Asp Ser Val Thr 
        35                  40                  45              


Leu Thr Cys Thr Gly Asn Asn Ser Leu Glu Val 
    50                  55                  


<210>  9
<211>  59
<212>  PRT
<213>  Cavia porcellus

<400>  9

Met Ala Ala Ala Val Tyr Gly Ser Ala Leu Leu Trp Ile Ala Leu Leu 
1               5                   10                  15      


Leu Phe Ser Pro Asp Gly Met Ile Met Ala Thr Gln Lys Ser Val Leu 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Tyr Arg Val Phe Glu Arg Asp Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Lys Asn Asn Leu Thr Glu Asp 
    50                  55                  


<210>  10
<211>  59
<212>  PRT
<213>  nomascus leucogenys

<400>  10

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Val Val Leu Thr Val Pro Gln Lys Pro Met Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val 
    50                  55                  


<210>  11
<211>  59
<212>  PRT
<213>  pongo abelli

<400>  11

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Met Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Phe Thr Cys Asn Gly Asn Asn Phe Phe Glu Val 
    50                  55                  


<210>  12
<211>  59
<212>  PRT
<213>  Gorilla gorilla gorilla

<400>  12

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Met Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val 
    50                  55                  


<210>  13
<211>  59
<212>  PRT
<213>  macaca fascicularis

<400>  13

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Thr Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Ser Asn Phe Phe Glu Val 
    50                  55                  


<210>  14
<211>  59
<212>  PRT
<213>  Saimiri boliviensis boliviensis

<400>  14

Met Ala Pro Leu Val Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Leu Phe Ala Pro Asp Gly Met Leu Ala Ala Pro Gln Lys Leu Met Ile 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Tyr Glu Val 
    50                  55                  


<210>  15
<211>  59
<212>  PRT
<213>  Callithrix jacchus

<400>  15

Met Ala Pro Leu Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Leu Phe Ala Pro Asp Gly Val Leu Ala Ala Leu Gln Lys Pro Thr Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Lys Gly Asn Asn Leu Tyr Glu Val 
    50                  55                  


<210>  16
<211>  59
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  16

Met Pro Thr Gly Met Gly Gly Pro Ile Leu Leu Cys Ile Ala Phe Leu 
1               5                   10                  15      


Leu Phe Ser Pro Asp Gly Thr Leu Ala Val Met Leu Lys Ser Val Val 
            20                  25                  30          


Ser Leu Tyr Pro Pro Trp Asn Arg Ile Phe Arg Gly Glu Ala Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asp Lys Ser Leu Asp Asp 
    50                  55                  


<210>  17
<211>  52
<212>  PRT
<213>  Myotis brandtii

<400>  17

Met Ser Thr Ser Met Gly Gly Pro Ala Leu Leu Trp Val Ala Leu Leu 
1               5                   10                  15      


Leu Phe Ser Ala Trp Lys Ser Met Met Ser Leu Asn Pro Pro Trp Asn 
            20                  25                  30          


Arg Ile Phe Arg Gly Glu Asn Val Thr Leu Thr Cys Asn Gly Asn Asn 
        35                  40                  45              


Ser Leu Asp Val 
    50          


<210>  18
<211>  60
<212>  PRT
<213>  pteropus alecto

<400>  18

Met Ser Thr Ser Met Gly Gly Pro Ala Leu Leu Trp Ile Ala Leu Leu 
1               5                   10                  15      


Leu Phe Ser Pro Asp Gly Met Ser Ala Glu Ala Asn Trp Lys Ser Met 
            20                  25                  30          


Val Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Arg Gly Glu Asn Val 
        35                  40                  45              


Thr Leu Thr Cys Asn Gly Asn Lys Ser Pro Glu Val 
    50                  55                  60  


<210>  19
<211>  55
<212>  PRT
<213>  Bos taurus

<400>  19

Met Gly Ala Pro Ala Leu Leu Trp Ile Ala Leu Leu Leu Phe Ser Pro 
1               5                   10                  15      


Asp Gly Met Ser Ala Ala Ile Trp Lys Ser Lys Val Ser Leu Asn Pro 
            20                  25                  30          


Pro Trp Arg Lys Ile Leu Lys Gly Asp Ala Val Thr Leu Thr Cys Gly 
        35                  40                  45              


Thr Asn Gly Ser Ser Glu Asp 
    50                  55  


<210>  20
<211>  59
<212>  PRT
<213>  Orcinus orca

<400>  20

Met Pro Thr Ala Met Gly Thr Pro Ala Leu Leu Trp Ile Ala Leu Leu 
1               5                   10                  15      


Leu Phe Ser Pro Asp Gly Ile Ser Ala Ala Ile Trp Arg Ser Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Arg Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Gly Gly Asn Asn Ser His Glu Asp 
    50                  55                  


<210>  21
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Pro Ala Met Glu Ser Pro Thr Leu Leu Cys Val Ala Leu Leu 
1               5                   10                  15      


Phe Phe Ala Pro Asp Gly Val Leu Ala Val Pro Gln Lys Pro Lys Val 
            20                  25                  30          


Ser Leu Asn Pro Pro Trp Asn Arg Ile Phe Lys Gly Glu Asn Val Thr 
        35                  40                  45              


Leu Thr Cys Asn Gly Asn Asn Phe Phe Glu Val 
    50                  55                  


<210>  22
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  22

Val Pro Gln Lys Pro Lys Val Ser Leu Asn Pro Pro Trp Asn Arg Ile 
1               5                   10                  15      


Phe Lys 
        


<210>  23
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Pro Gln Lys Pro Lys 
1               5       


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

Val Ser Leu Asn Pro Pro Trp Asn Arg 
1               5                   


<210>  25
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile Thr Val Ile 
1               5                   10                  15      


Lys Ala Pro Arg Glu Lys 
            20          


<210>  26
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  26

Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile Thr Val Ile 
1               5                   10                  15      


Lys Ala Pro Arg 
            20  


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Trp Gln Leu Asp Tyr Glu Ser Glu Pro Leu Asn Ile Thr Val Ile 
1               5                   10                  15      


Lys 
    


<210>  28
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  28

Trp Phe His Asn Gly Ser Leu Ser Glu Glu Thr Asn Ser Ser Leu Asn 
1               5                   10                  15      


Ile Val Asn Ala Lys Phe Glu Asp Ser Gly Glu Tyr Lys 
            20                  25                  


<210>  29
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Lys Tyr Trp Leu Gln Gly Gly Gly Ser Asp Ala His Lys Ser Glu 
1               5                   10                  15      


Val Ala His Arg 
            20  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
1               5                   10  


