               SEQUENCE LISTING

<110> VHsquared Limited

<120> Polypeptides

<130> VHS-P1921PCT

<160> 96

<170> BiSSAP 1.3

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V CDR1

<400> 1
Ile Asn Val Met Ala 
1               5   

<210> 2
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V CDR2

<400> 2
Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp Phe Val Lys Gly 
1               5                   10                  15      



<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V CDR3

<400> 3
Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
1               5                   10          

<210> 4
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V FR1

<400> 4
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser 
    

<210> 5
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V FR2

<400> 5
Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val Ala 
1               5                   10                  

<210> 6
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V FR3

<400> 6
Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala 
            20                  25                  30          



<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V FR4

<400> 7
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V CDR1

<400> 8
Ile Asn Val Ile Gly 
1               5   

<210> 9
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V CDR2

<400> 9
Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys Gly 
1               5                   10                  15      



<210> 10
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V FR1

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser 
            20                  25                  30  

<210> 11
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V FR2

<400> 11
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  

<210> 12
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V FR3

<400> 12
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala 
            20                  25                  30          



<210> 13
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence of 3’ primer

<400> 13
tcttaactag tgaggagacg gtgacctg                                       28


<210> 14
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V CDR3

<400> 14
Asp Tyr Glu Asp His Asp Ser Pro His Asn Gly Ser 
1               5                   10          

<210> 15
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 5G9

<400> 15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 16
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-52V

<400> 16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 17
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-53V

<400> 17
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 18
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-54V

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 19
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-55V

<400> 19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys His Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 20
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-56V

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 21
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-57V

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ile Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 22
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-58V

<400> 22
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Val Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 23
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-59V

<400> 23
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Asp Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 24
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-112V

<400> 24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 25
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-114V

<400> 25
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 26
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-122V

<400> 26
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 27
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-123V

<400> 27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 28
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-141V

<400> 28
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 29
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-142V

<400> 29
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 30
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-143V

<400> 30
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 31
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-144V

<400> 31
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 32
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 7F6

<400> 32
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 33
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-3V

<400> 33
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 34
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-6V

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp Arg Asp Ser Pro His Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 35
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-40V

<400> 35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp His Asp Ser Pro His Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 36
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-47V

<400> 36
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp Arg Asp Ser Pro Ile Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 37
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-49V

<400> 37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp Arg Asp Ser Pro Thr Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 38
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-50V

<400> 38
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp Arg Asp Ser Pro Val Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 39
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 21E6

<400> 39
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Leu Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          
Val Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              
Ala Met Ile Gly Arg Gly Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      
Ala Asp Tyr Glu Asp Arg Asp Ser Pro Leu Asn Gly Ser Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 

<210> 40
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 4D3

<400> 40
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Glu 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Val Ala Ser Ile Ser Thr Phe Ser Gln Asn 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Ala Gly Lys Arg Arg Glu Ser Val 
        35                  40                  45              
Ala Arg Ile Ser Ser Ser Gly Asn Val Gly Tyr Thr Asp Ala Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Tyr Ser Met Ser Gly Glu Leu Ala Ala Pro Trp Gly Gln Gly Thr 
            100                 105                 110         
Gln Val Thr Val Ser Ser 
        115             

<210> 41
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 3C12

<400> 41
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Leu Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Asn Ile Phe Ser Ser Asn 
            20                  25                  30          
Thr Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              
Ala Gly Ile Ser Ile Gly Gly Met Pro Ala Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Thr Gly Gly Thr Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         
Val Ser Ser 
        115 

<210> 42
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 20A11

<400> 42
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Val Phe Lys Ile Asn 
            20                  25                  30          
Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val 
        35                  40                  45              
Ala Gly Ile Ile Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Phe Ile Thr Thr Glu Ser Asp Tyr Asp Leu Gly Arg Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     

<210> 43
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-74V

<400> 43
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 44
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-75V

<400> 44
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser Ile Asn Val Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp 
    50                  55                  60                  
Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr 
65                  70                  75                  80  
Val Asn Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Tyr Ala Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 45
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-2A

<400> 45
Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Val Ile Ser Gly Met Asp Phe Ser His Lys 
            20                  25                  30          
Pro Ala Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ser Ile Thr Thr Arg Ala Ser Thr His Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Asn 
                85                  90                  95      
Ser Glu Tyr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     

<210> 46
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-58V CDR2

<400> 46
Ile Ile Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp Val Val Lys Gly 
1               5                   10                  15      



<210> 47
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-59V CDR2

<400> 47
Ile Ile Gly Lys Gly Gly Gly Thr Asn Asp Ala Asp Phe Val Lys Gly 
1               5                   10                  15      



<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR3 of multiple ICVDs including 5G9

<400> 48
Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Ala Ser 
1               5                   10          

<210> 49
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-53V CDR3

<400> 49
Asp Tyr Glu Asp Arg Asp Ser Pro His Asn Ala Ser 
1               5                   10          

<210> 50
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of CDR3 of multiple ICVDs including ID-143V

<400> 50
Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Ala Ser 
1               5                   10          

<210> 51
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 7F6 CDR3

<400> 51
Asp Tyr Glu Asp Arg Asp Ser Pro Phe Asn Gly Ser 
1               5                   10          

<210> 52
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-3V CDR3

<400> 52
Asp Tyr Glu Asp His Asp Ser Pro Phe Asn Gly Ser 
1               5                   10          

<210> 53
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-6V CDR3

<400> 53
Asp Tyr Glu Asp Arg Asp Ser Pro His Asn Gly Ser 
1               5                   10          

<210> 54
<211> 1407
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding human IL-6R

<400> 54
atgctggccg tcggctgcgc gctgctggct gccctgctgg ccgcgccggg agcggcgctg      60

gccccaaggc gctgccctgc gcaggaggtg gcaagaggcg tgctgaccag tctgccagga     120

gacagcgtga ctctgacctg cccgggggta gagccggaag acaatgccac tgttcactgg     180

gtgctcagga agccggctgc aggctcccac cccagcagat gggctggcat gggaaggagg     240

ctgctgctga ggtcggtgca gctccacgac tctggaaact attcatgcta ccgggccggc     300

cgcccagctg ggactgtgca cttgctggtg gatgttcccc ccgaggagcc ccagctctcc     360

tgcttccgga agagccccct cagcaatgtt gtttgtgagt ggggtcctcg gagcacccca     420

tccctgacga caaaggctgt gctcttggtg aggaagtttc agaacagtcc ggccgaagac     480

ttccaggagc cgtgccagta ttcccaggag tcccagaagt tctcctgcca gttagcagtc     540

ccggagggag acagctcttt ctacatagtg tccatgtgcg tcgccagtag tgtcgggagc     600

aagttcagca aaactcaaac ctttcagggt tgtggaatct tgcagcctga tccgcctgcc     660

aacatcacag tcactgccgt ggccagaaac ccccgctggc tcagtgtcac ctggcaagac     720

ccccactcct ggaactcatc tttctacaga ctacggtttg agctcagata tcgggctgaa     780

cggtcaaaga cattcacaac atggatggtc aaggacctcc agcatcactg tgtcatccac     840

gacgcctgga gcggcctgag gcacgtggtg cagcttcgtg cccaggagga gttcgggcaa     900

ggcgagtgga gcgagtggag cccggaggcc atgggcacgc cttggacaga atccaggagt     960

cctccagctg agaacgaggt gtccaccccc atgcaggcac ttactactaa taaagacgat    1020

gataatattc tcttcagaga ttctgcaaat gcgacaagcc tcccagtgca agattcttct    1080

tcagtaccac tgcccacatt cctggttgct ggagggagcc tggccttcgg aacgctcctc    1140

tgcattgcca ttgttctgag gttcaagaag acgtggaagc tgcgggctct gaaggaaggc    1200

aagacaagca tgcatccgcc gtactctttg gggcagctgg tcccggagag gcctcgaccc    1260

accccagtgc ttgttcctct catctcccca ccggtgtccc ccagcagcct ggggtctgac    1320

aatacctcga gccacaaccg accagatgcc agggacccac ggagccctta tgacatcagc    1380

aatacagact acttcttccc cagatag                                        1407


<210> 55
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-47V CDR3

<400> 55
Asp Tyr Glu Asp Arg Asp Ser Pro Ile Asn Gly Ser 
1               5                   10          

<210> 56
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-49V CDR3

<400> 56
Asp Tyr Glu Asp Arg Asp Ser Pro Thr Asn Gly Ser 
1               5                   10          

<210> 57
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of ID-50V CDR3

<400> 57
Asp Tyr Glu Asp Arg Asp Ser Pro Val Asn Gly Ser 
1               5                   10          

<210> 58
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of 21E6 CDR3

<400> 58
Asp Tyr Glu Asp Arg Asp Ser Pro Leu Asn Gly Ser 
1               5                   10          

<210> 59
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding 5G9

<400> 59
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 60
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding 5G9 (codon optimised)

<400> 60
gaagtccaat tggttgaatc tggtggtggt ttggttcaag ccggtggttc tactagattg      60

acttgtaaag cttccggttc catcttcaac atcaactcca ttaacgttat ggcctggtat     120

agacaagctc caggtaaaca aagagaattg gttgccatta ttggtaaggg tggtggtact     180

aattatgccg attttgttaa gggtagattc accatttcta gagatgctgc taagaacacc     240

gttaacttgc aaatgaattc cttgaagcca gaagataccg ctgtttatta ctgttacgct     300

gactacgaag atagagactc tccttttaat gcttcttggg gtcaaggtac tcaggtcacc     360

gtttcttct                                                             369


<210> 61
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding 7F6

<400> 61
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc tacgaggctc      60

acctgtttag cctctggaag tatcagcagt atcaatgtca taggatggta ccgccaggct     120

ccagggaagc agcgcgagtt ggtcgcaatg attggtagag gtgaaggcgc aaactatgga     180

gacttcgcga agggccgatt caccatctcc agagacaata gcaagaacac ggtgtatctg     240

caaatgaaca gcttgaaacc tgaggacacg gccgtctatt actgttatgc agattatgaa     300

gatcgggatt ctccgtttaa tggttcctgg ggccagggga cccaggtcac cgtctcctca     360


<210> 62
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding 21E6

<400> 62
gaggtgcagc tggtggagtc tgggggaggt ttggtgctcg ctggggggtc tacgaggctc      60

acctgtttag cctctggaag tatcagcagt atcaatgtca taggatggta ccgccaggct     120

ccagggaagc agcgcgagtt ggtcgcaatg attggtagag gtgaaggcgc aaactatgga     180

gacttcgcga agggccgatt caccatctcc agagacaata gcaagaacac ggtgtatctg     240

caaatgaaca gcttgaaacc tgaggacacg gccgtctatt actgttatgc agattatgaa     300

gatcgggatt ctccgctcaa tggttcctgg ggccagggga cccaggtcac cgtctcctca     360


<210> 63
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-52V

<400> 63
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcatgattc cccgcacaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 64
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-53V

<400> 64
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgcataac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 65
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-54V

<400> 65
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcatgattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 66
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-55V

<400> 66
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtcatg cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 67
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-56V

<400> 67
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatctctaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 68
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-57V

<400> 68
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcattaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 69
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-58V

<400> 69
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acgttgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 70
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-59V

<400> 70
gaggtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aacgatgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcgggattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 71
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-74V

<400> 71
gatgtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcttcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcacgattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 72
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-75V

<400> 72
gatgtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcagcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaagca gcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtaaatctgc aaatgaacag cttgaaacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcacgattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 73
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-112V

<400> 73
gaagttcagc tggttgaaag cggtggtggt ctggttcagg caggcggtag cacccgtctg      60

acctgtaaag caagcggtag cattagcaat attaacagca ttaatgtgat ggcctggtat     120

cgtcaggcac cgggtaaagg tcgtgaactg gttgcaatta ttggtaaagg tggtggcacc     180

aattatgccg attttgtgaa aggtcgtttt accattagcc gtgatgcagc aaaaaatacc     240

gttaacctgc agatgaatag cctgcgtccg gaagataccg cagtgtatta ttgttatgcg     300

gattatgaag atcacgacag cccgtttaat gcaagctggg gtcagggcac ccaggtcacc     360

gttagcagc                                                             369


<210> 74
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-114V

<400> 74
gaagttcagc tggttgaaag cggtggtggt ctggttcagg caggcggtag cacccgtctg      60

acctgtaaag caagcggtag cattagcaat attaacagca ttaatgtgat ggcctggtat     120

cgtcaggcac cgggtaaaca gcgtgaactg gttgcaatta ttggtaaagg tggtggcacc     180

aattatgccg attttgttaa aggtcgtttt accattagcc gtgatgcagc aaaaaatacc     240

ctgtacctgc agatgaatag cctgaaaccg gaagataccg cagtgtatta ttgttatgcg     300

gattatgaag atcacgacag cccgtttaat gcaagctggg gtcagggcac ccaggtcacc     360

gttagcagc                                                             369


<210> 75
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-122V

<400> 75
gaagttcagc tggttgaaag cggtggtggt ctggttcagg caggcggtag cacccgtctg      60

acctgtaaag caagcggtag cattagcaat attaacagca ttaatgtgat ggcctggtat     120

cgtcaggcac cgggtaaagg tcgtgaactg gttgcaatta ttggtaaagg tggtggcacc     180

aattatgccg attttgtgaa aggtcgtttt accattagcc gtgatgcagc aaaaaatacc     240

gttaacctgc agatgaatag cctgcgtccg gaagataccg cagtgtatta ttgttatgcg     300

gattatgagg atcatgacag tccgcataat gcaagctggg gtcagggcac ccaggtcacc     360

gttagcagc                                                             369


<210> 76
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-123V

<400> 76
gaagttcagc tggttgaaag cggtggtggt ctggttcagg caggcggtag cacccgtctg      60

acctgtaaag caagcggtag cattagcaat attaacagca ttaatgtgat ggcctggtat     120

cgtcaggcac cgggtaaagg tcgtgaactg gttgcaatta ttggtaaagg tggtggcacc     180

aattatgccg attttgtgaa aggtcgtttt accattagcc gtgatgcagc aaaaaatacc     240

gtttacctgc agatgaatag cctgcgtccg gaagataccg cagtgtatta ttgttatgcg     300

gattatgagg atcatgacag tccgcataat gcaagctggg gtcagggcac ccaggtcacc     360

gttagcagc                                                             369


<210> 77
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-141V

<400> 77
gatgtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcagcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaaggg tcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

ttgtatctgc aaatgaacag cttgagacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcacgattc cccgcataac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 78
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-142V

<400> 78
gatgtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcagcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaaggg tcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtatatctgc aaatgaacag cttgagacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcacgattc cccgcataac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 79
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-143V

<400> 79
gatgtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcagcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaaggg tcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

ttgtatctgc aaatgaacag cttgagacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcacgattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 80
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Polynucleotide sequence encoding ID-144V

<400> 80
gatgtgcagc tggtggagtc tgggggaggt ttggtgcagg ctggggggtc aacgagactc      60

acctgtaaag cctctggaag tatcagcaat atcaacagta tcaacgtcat ggcatggtac     120

cgccaggctc cagggaaggg tcgcgaattg gtcgcaatta ttggtaaagg tggtgggaca     180

aactacgcag acttcgtgaa gggccgattc accatttcca gagatgctgc caagaacacg     240

gtatatctgc aaatgaacag cttgagacct gaggacacgg ccgtctatta ctgttatgcg     300

gattatgaag atcacgattc cccgtttaac gcttcctggg gccaggggac ccaggtcacc     360

gtctcctca                                                             369


<210> 81
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of human IL-6R

<400> 81
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      
Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          
Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              
Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  
Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  
Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      
Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         
Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             
Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 
Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 
Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     
Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         
Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             
Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 
Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 
Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     
Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         
Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             
Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 
Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 
Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     
Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         
Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             
Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 
Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 
Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     
Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         
Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             
Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 
Phe Phe Pro Arg 
465             

<210> 82
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of mature human IL-6R (cleaved at L20)

<400> 82
Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg Gly Val Leu 
1               5                   10                  15      
Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro Gly Val Glu 
            20                  25                  30          
Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys Pro Ala Ala 
        35                  40                  45              
Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg Leu Leu Leu 
    50                  55                  60                  
Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala 
65                  70                  75                  80  
Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val Pro Pro Glu 
                85                  90                  95      
Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser Asn Val Val 
            100                 105                 110         
Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr Lys Ala Val 
        115                 120                 125             
Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu 
    130                 135                 140                 
Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala 
145                 150                 155                 160 
Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met Cys Val Ala 
                165                 170                 175     
Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys 
            180                 185                 190         
Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val 
        195                 200                 205             
Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser 
    210                 215                 220                 
Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala 
225                 230                 235                 240 
Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His 
                245                 250                 255     
His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln 
            260                 265                 270         
Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser 
        275                 280                 285             
Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala 
    290                 295                 300                 
Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr Asn Lys Asp 
305                 310                 315                 320 
Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro 
                325                 330                 335     
Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu Val Ala Gly 
            340                 345                 350         
Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile Val Leu Arg 
        355                 360                 365             
Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly Lys Thr Ser 
    370                 375                 380                 
Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu Arg Pro Arg 
385                 390                 395                 400 
Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val Ser Pro Ser 
                405                 410                 415     
Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro Asp Ala Arg 
            420                 425                 430         
Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr Phe Phe Pro 
        435                 440                 445             
Arg 
    

<210> 83
<211> 346
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of soluble human IL-6R isoform produced by
      differential mRNA splicing

<400> 83
Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg Gly Val Leu 
1               5                   10                  15      
Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro Gly Val Glu 
            20                  25                  30          
Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys Pro Ala Ala 
        35                  40                  45              
Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg Leu Leu Leu 
    50                  55                  60                  
Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala 
65                  70                  75                  80  
Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val Pro Pro Glu 
                85                  90                  95      
Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser Asn Val Val 
            100                 105                 110         
Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr Lys Ala Val 
        115                 120                 125             
Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu 
    130                 135                 140                 
Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala 
145                 150                 155                 160 
Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met Cys Val Ala 
                165                 170                 175     
Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys 
            180                 185                 190         
Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val 
        195                 200                 205             
Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser 
    210                 215                 220                 
Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala 
225                 230                 235                 240 
Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His 
                245                 250                 255     
His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln 
            260                 265                 270         
Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser 
        275                 280                 285             
Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala 
    290                 295                 300                 
Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr Asn Lys Asp 
305                 310                 315                 320 
Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro 
                325                 330                 335     
Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
            340                 345     

<210> 84
<211> 338
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of soluble human IL-6R isoform produced by
      protease shedding

<400> 84
Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg Gly Val Leu 
1               5                   10                  15      
Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro Gly Val Glu 
            20                  25                  30          
Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys Pro Ala Ala 
        35                  40                  45              
Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg Leu Leu Leu 
    50                  55                  60                  
Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala 
65                  70                  75                  80  
Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val Pro Pro Glu 
                85                  90                  95      
Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser Asn Val Val 
            100                 105                 110         
Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr Lys Ala Val 
        115                 120                 125             
Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu 
    130                 135                 140                 
Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala 
145                 150                 155                 160 
Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met Cys Val Ala 
                165                 170                 175     
Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys 
            180                 185                 190         
Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val 
        195                 200                 205             
Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser 
    210                 215                 220                 
Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala 
225                 230                 235                 240 
Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His 
                245                 250                 255     
His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln 
            260                 265                 270         
Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser 
        275                 280                 285             
Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala 
    290                 295                 300                 
Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr Asn Lys Asp 
305                 310                 315                 320 
Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr Ser Leu Pro 
                325                 330                 335     
Val Gln 
        

<210> 85
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of predicted full length precursor
      cynomolgous monkey IL-6R

<400> 85
Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      
Gly Ala Ala Leu Ala Pro Gly Gly Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          
Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              
Gly Gly Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  
Pro Ala Val Gly Ser His Leu Ser Arg Trp Ala Gly Val Gly Arg Arg 
65                  70                  75                  80  
Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      
Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         
Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             
Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Pro Thr Thr 
    130                 135                 140                 
Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 
Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     
Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         
Cys Val Ala Ser Ser Val Gly Ser Lys Leu Ser Lys Thr Gln Thr Phe 
        195                 200                 205             
Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 
Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 
Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     
Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         
Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             
Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 
Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 
Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Thr Gln Ala Pro Thr Thr 
                325                 330                 335     
Asn Lys Asp Asp Asp Asn Ile Leu Ser Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         
Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             
Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 
Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 
Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     
Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         
Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             
Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 
Phe Phe Pro Arg 
465             

<210> 86
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR1 of ID-141V, ID-142V, ID-143V and
      ID-144V

<400> 86
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Thr Arg Leu Thr Cys Lys Ala Ser Gly Ser Ile Ser Asn Ile Asn 
            20                  25                  30          
Ser 
    

<210> 87
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR2 of ID-141V, ID-142V, ID-143V and
      ID-144V

<400> 87
Trp Tyr Arg Gln Ala Pro Gly Lys Gly Arg Glu Leu Val Ala 
1               5                   10                  

<210> 88
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR3 of ID-141V and ID-143V

<400> 88
Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala 
            20                  25                  30          



<210> 89
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR3 of ID-142V and ID-144V

<400> 89
Arg Phe Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala 
            20                  25                  30          



<210> 90
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide sequence of FR4 of ID-141V, ID-142V, ID-143V and
      ID-144V

<400> 90
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 91
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide VHHR sequence of 7F6

<400> 91
Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Thr Arg Leu Thr Cys 
1               5                   10                  15      
Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn Val Ile Gly Trp Tyr Arg 
            20                  25                  30          
Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Met Ile Gly Arg Gly 
        35                  40                  45              
Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  
Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
65                  70                  75                  80  
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg 
                85                  90                  95      
Asp Ser Pro Phe Asn Gly Ser Trp Gly Gln Gly 
            100                 105         

<210> 92
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide VHHR sequence of 5G9

<400> 92
Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Thr Arg Leu Thr Cys 
1               5                   10                  15      
Lys Ala Ser Gly Ser Ile Phe Asn Ile Asn Ser Ile Asn Val Met Ala 
            20                  25                  30          
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ile Ile 
        35                  40                  45              
Gly Lys Gly Gly Gly Thr Asn Tyr Ala Asp Phe Val Lys Gly Arg Phe 
    50                  55                  60                  
Thr Ile Ser Arg Asp Ala Ala Lys Asn Thr Val Asn Leu Gln Met Asn 
65                  70                  75                  80  
Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr 
                85                  90                  95      
Glu Asp Arg Asp Ser Pro Phe Asn Gly Ser Trp Gly Gln Gly 
            100                 105                 110 

<210> 93
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide VHHR sequence of 21E6

<400> 93
Ser Gly Gly Gly Leu Val Leu Ala Gly Gly Ser Thr Arg Leu Thr Cys 
1               5                   10                  15      
Leu Ala Ser Gly Ser Ile Ser Ser Ile Asn Val Ile Gly Trp Tyr Arg 
            20                  25                  30          
Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Met Ile Gly Arg Gly 
        35                  40                  45              
Glu Gly Ala Asn Tyr Gly Asp Phe Ala Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  
Arg Asp Asn Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
65                  70                  75                  80  
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr Ala Asp Tyr Glu Asp Arg 
                85                  90                  95      
Asp Ser Pro Leu Asn Gly Ser Trp Gly Gln Gly 
            100                 105         

<210> 94
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide germline equivalent sequence of 7F6

<400> 94
Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      
Ala Ala Ser Gly Ser Ile Phe Ser Ile Asn Ala Met Gly Trp Tyr Arg 
            20                  25                  30          
Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly 
        35                  40                  45              
Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  
Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
65                  70                  75                  80  
Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp Tyr Glu Asp Arg 
                85                  90                  95      
Asp Ser Pro Phe Asn Gly Ser Trp Gly Gln Gly 
            100                 105         

<210> 95
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide germline equivalent sequence of 5G9

<400> 95
Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      
Ala Ala Ser Gly Ser Ile Phe Asn Ile Asn Ser Ile Asn Ala Met Gly 
            20                  25                  30          
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile 
        35                  40                  45              
Thr Ser Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    50                  55                  60                  
Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn 
65                  70                  75                  80  
Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala Asp Tyr 
                85                  90                  95      
Glu Asp Arg Asp Ser Pro Phe Asn Gly Ser Trp Gly Gln Gly 
            100                 105                 110 

<210> 96
<211> 104
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide germline equivalent sequence of 21E6

<400> 96
Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      
Gly Ser Ile Phe Ser Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro 
            20                  25                  30          
Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Gly Ser Thr 
        35                  40                  45              
Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    50                  55                  60                  
Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
65                  70                  75                  80  
Thr Ala Val Tyr Tyr Cys Asn Ala Asp Tyr Glu Asp Arg Asp Ser Pro 
                85                  90                  95      
Leu Asn Gly Ser Trp Gly Gln Gly 
            100                 

