                               SEQUENCE LISTING

<110> VITRISA THERAPEUTICS, INC.
 
<120> COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D

<130> 49644-701.601

<140>
<141>

<150> 62/297,095
<151> 2016-02-18

<150> 62/281,092
<151> 2016-01-20

<160> 95    

<170> PatentIn version 3.5

<210> 1
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
gggagugugu acgaggcauu aggccgccac ccaaacugca guccucguaa gucugccugg       60

cggcuuugau acuugaucgc ccuagaagc                                         89


<210> 2
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
gggagugugu acgaggcauu aguccgccga agucuuuugg cucgguuuuu ucaaggucgg       60

cggcuuugau acuugaucgc ccuagaagc                                         89


<210> 3
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gggagugugu acgaggcauu aggccgccac cucguuugau ugcgguuguu cggccgcggg       60

cggcuuugau acuugaucgc ccuagaagc                                         89


<210> 4
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gtgacgactg acatatctgc tccgaggtta ttggggttgg ggcctgggcg attggggcct       60

cgtagttgag tctgagtgct                                                   80


<210> 5
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gtgacgactg acatatctgc gtttggggtt ggggcctggg agtttgggga gcagaaagga       60

cgtagttgag tctgagtgct                                                   80


<210> 6
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gtgacgactg acatatctgc tgtgggtgtt gtgggggtgg gtggtgggcc cttcgccatg       60

cgtagttgag tctgagtgct                                                   80


<210> 7
<211> 77
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
gtgacgactg acatatctgc ggcggttggg gtcgaagggc gaggggtggg aggtcgccgt       60

agttgagtct gagtgct                                                      77


<210> 8
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gtgacgactg acatatctgc tattttgggg cctgggtgtt ggggattggg gactatgtgt       60

cgtagttgag tctgagtgct                                                   80


<210> 9
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gtgacgactg acatatctgc tgtggatggt ggggggtggt gtgggagggc tggtcggtcg       60

cgtagttgag tctgagtgct                                                   80


<210> 10
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
gtgacgactg acatatctgc cctatagggg tgtgggcgag gggtgggtgg tagggcggct       60

cgtagttgag tctgagtgct                                                   80


<210> 11
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gtgacgactg acatatctgc ggaggtgggt gggtgggtgc gtgcgagggc ggtgtaggtc       60

cgtagttgag tctgagtgct                                                   80


<210> 12
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gtgacgactg acatatctgc aaaagttaga ttgacatggt atgcaccgtc tgaggttggt       60

cgtagttgag tctgagtgct                                                   80


<210> 13
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gtgacgactg acatatctgc accacgctag gggtgagggc gaggggtggg tagcgcgtgg       60

cgtagttgag tctgagtgct                                                   80


<210> 14
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gtgacgactg acatatctgc tgtgggtgtt gtgggggcgg gtggtgggtg cgtcggtggt       60

cgtagttgag tctgagtgct                                                   80


<210> 15
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gtgacgactg acatatctgc tgcttccagc ggtcatgata tgcactgtct gaagctcggt       60

cgtagttgag tctgagtgct                                                   80


<210> 16
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
gtgacgactg acatatctgc tgtgttatga tatgcaccgt ctgagggtag tcgcggggtg       60

cgtagttgag tctgagtgct                                                   80


<210> 17
<211> 79
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
gtgacgactg acatatctgc tgcttgttta gtgggtgggt gggtggtgtg gtggtgatgc       60

gtagttgagt ctgagtgct                                                    79


<210> 18
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
gtgacgactg acatatctgc cttggggttg gggcctgggt gtttggggtg gcctagaagt       60

cgtagttgag tctgagtgct                                                   80


<210> 19
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gtgacgactg acatatctgc gctaggggtg ggttggggtt ggtggtgtgc gtgtgggttg       60

cgtagttgag tctgagtgct                                                   80


<210> 20
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gtgacgactg acatatctgc tgttgaggtt ggtggggggt gggcggtggg atggttgtgc       60

cgtagttgag tctgagtgct                                                   80


<210> 21
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
gtgacgactg acatatctgc ttgacagtct gctttgcagg ggccgagagc gccattgcgt       60

cgtagttgag tctgagtgct                                                   80


<210> 22
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
gtgacgactg acatatctgc tgtggttggt ggggggtgga gggtgggagg ccgtgtgtcc       60

cgtagttgag tctgagtgct                                                   80


<210> 23
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
gtgacgactg acatatctgc tgtggtggtg ggggagggtg gtggggtggc cggcgctcgt       60

cgtagttgag tctgagtgct                                                   80


<210> 24
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gtgacgactg acatatctgc tgggttacgt ggttcggggc taggggggtg gggtgtgttt       60

cgtagttgag tctgagtgct                                                   80


<210> 25
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
gtgacgactg acatatctgc tggtggtgtg cggtgggttc ttgggtggga tgggtggtac       60

cgtagttgag tctgagtgct                                                   80


<210> 26
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gtgacgactg acatatctgc tattagatcc tcggtgggtg ggtgggtgtg tggtggtgtg       60

cgtagttgag tctgagtgct                                                   80


<210> 27
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
gtgacgactg acatatctgc gggcgtctga gcgcatggat gacccaccga cagattgcgg       60

cgtagttgag tctgagtgct                                                   80


<210> 28
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
gtgacgactg acatatctgc gctttgggtg ggctcggtgt gcggtgtgcg ggtgggtttg       60

cgtagttgag tctgagtgct                                                   80


<210> 29
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
gtgacgactg acatatctgc gtttggggtt ggggcctggg agtttgggga gcagaaaggg       60

cgtagttgag tctgagtgct                                                   80


<210> 30
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
gtgacgactg acatatctgc gggtgggttg ggttgggttt ggtggtggtg cctgttagtt       60

cgtagttgag tctgagtgct                                                   80


<210> 31
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
gtgacgactg acatatctgc aggtgggtgg gtgggtgtgt gtgcggtggt gtgatttggc       60

cgtagttgag tctgagtgct                                                   80


<210> 32
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
gtgacgactg acatatctgc tgtggttggt ggggggcggc gggtggggag cctggtgttc       60

cgtagttgag tctgagtgct                                                   80


<210> 33
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
gtgacgactg acatatctgc tcccgtttga gggcttgtcg gacagattgc tggcacgtca       60

cgtagttgag tctgagtgct                                                   80


<210> 34
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
gtgacgactg acatatctgc tcttggtggt ggtggtgggt tgggatgggt cttgggctgc       60

cgtagttgag tctgagtgct                                                   80


<210> 35
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
gtgacgactg acatatctgc ctgtgagggg agggagggtg ggtttggcgg tggcgcaggc       60

cgtagttgag tctgagtgct                                                   80


<210> 36
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
gtgacgactg acatatctgc gtggtggtgc gtgggtggtg ggggggggag ctgggtgccc       60

cgtagttgag tctgagtgct                                                   80


<210> 37
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
gtgacgactg acatatctgc tgtgggtgtt gtgggggtgg gtggtgggcc cttcgccgtg       60

cgtagttgag tctgagtgct                                                   80


<210> 38
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
gtgacgactg acatatctgc ttccggtatg tgtgggtggg tgggtggtgt ggtggtgttg       60

cgtagttgag tctgagtgct                                                   80


<210> 39
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
gtgacgactg acatatctgc tctcttctgt tgtgggtggg tgggtggtgt ggtgcgtgtg       60

cgtagttgag tctgagtgct                                                   80


<210> 40
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
gtgacgactg acatatctgc ggctgggtgg gttgggttag ggtggtgtgc ggtgggttgc       60

cgtagttgag tctgagtgct                                                   80


<210> 41
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
gtgacgactg acatatctgc gtttaggtgg gcgggtgggt gtgcggtggg cggtgttgaa       60

cgtagttgag tctgagtgct                                                   80


<210> 42
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
gtgacgactg acatatctgc ggtgattggg gttggggcct gggcgtttgg ggaccgcatg       60

cgtagttgag tctgagtgct                                                   80


<210> 43
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
gtgacgactg acatatctgc gtttggggtt ggggcctggg agtttgggga gcagagagga       60

cgtagttgag tctgagtgct                                                   80


<210> 44
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
gtgacgactg acatatctgc taacttgttg gggtttgggg cctgggtgtt ggggttgttt       60

cgtagttgag tctgagtgct                                                   80


<210> 45
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
gtgacgactg acatatctgc tggggttggt ggggggaggt gggtgggtta tgtgcgctgg       60

cgtagttgag tctgagtgct                                                   80


<210> 46
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
gtgacgactg acatatctgc tgtgggtgtt gtgggggtgg gttggtgggc attgcgtgtg       60

cgtagttgag tctgagtgct                                                   80


<210> 47
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
gtgacgactg acatatctgc gagtgggttc ggtggtggtg tgtgggaggg ttgggtacgt       60

cgtagttgag tctgagtgct                                                   80


<210> 48
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
gtgacgactg acatatctgc tggacatgat tgcaccgtat gaggtttagt cgttaatgtg       60

cgtagttgag tctgagtgct                                                   80


<210> 49
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
gtgacgactg acatatctgc agtggggcct gggcgttggg gtttggggtg cctcgtcagt       60

cgtagttgag tctgagtgct                                                   80


<210> 50
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
gtgacgactg acatatctgc atggattttc ggtgggtggg tgggttggtg tggtggtgtg       60

cgtagttgag tctgagtgct                                                   80


<210> 51
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
gtgacgactg acatatctgc tgtggttggt ggggggtggg tggtgggaag gttccggtgc       60

cgtagttgag tctgagtgct                                                   80


<210> 52
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
gtgacgactg acatatctgc ggttggggtt ggggcctggg tgttggggag caggtagcac       60

cgtagttgag tctgagtgct                                                   80


<210> 53
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
gtgacgactg acatatctgc ggcctgggag ggttcggtgg tggtgcgagg gtgggcaagc       60

cgtagttgag tctgagtgct                                                   80


<210> 54
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 54
acctagtttg gcttgcauaa gtaacuagca cgtgggctag                             40


<210> 55
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 55
acgatcgccc cugtctutaa gaucgaatac tatgggctag                             40


<210> 56
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 56
acctagaaag gcttagtgaa gtaaugatca gggcgggatc                             40


<210> 57
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 57
acctagttcc cugtctauua gauccgagug tatgccgatc                             40


<210> 58
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 58
acctaggcag tcttgccgaa tttacgagug gggagggatc                             40


<210> 59
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 59
acgatcactg cucagcutua ttaacuagcu tcgaccctag                             40


<210> 60
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 60
acgatcttcc gccagctgua ttucgaagug cgtgaggatc                             40


<210> 61
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 61
acctaggcgg tcttuccgtc gttacgtccu cggcccctag                             40


<210> 62
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 62
acctagtttg gcgtagcgua ttaaugggug cggcagctag                             40


<210> 63
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 63
acgatcgctg acgtucauua gtatgaggca cgtgggctag                             40


<210> 64
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
tcttaatacg actcactata gggagtgtgt acgaggcatt a                           41


<210> 65
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
gcttctaggg cgatcaagta tca                                               23


<210> 66

<400> 66
000


<210> 67
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(60)
<223> a, c, t or g 

<400> 67
gtgacgactg acatatctgc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

cgtagttgag tctgagtgct                                                   80


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
gtgacgactg acatatctgc                                                   20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
agcactcaga ctcaactacg                                                   20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
aaaaaaaaaa aaaaaaaaaa                                                   20


<210> 71
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 71
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
        115                 120                 125             


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220         


<210> 72
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 72
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Asp Asp Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 73
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
acggagaaag agagagtgta attgctagca taaccgctgc                             40


<210> 74
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 74
gtaaccacgt tgccagaccg agtctaccag cgatcctcag                             40


<210> 75
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 75
tatgcccaaa tccctcaagt cggccaggat acaccaccgt                             40


<210> 76
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
aatcaaaagg ctcacgcgcg gattggtcaa ccttacaacc                             40


<210> 77
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 77
tcggccttcc cagaccaccg caatccccag ggaacaggca                             40


<210> 78
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 78
catcacactg tcaacatacc cagcctgggg aaagacgaac                             40


<210> 79
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
aacccgcatg ccgatcgatg tcgtgcctcg ctccacgctc                             40


<210> 80
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
accaggcacc cgacggacta actcatcact caggcgaggg                             40


<210> 81
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 81
ucatgccatt actcucgact gugccugaat                                        30


<210> 82
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 82
cctgugagcc tgatcgagac atgtcggaag                                        30


<210> 83
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 83
gtctaccttc tauaaagggt cctctttacu                                        30


<210> 84
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 84
caggtttggu ctugtattgc cgauugccca                                        30


<210> 85
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Asn Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 86
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 86
Glu Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Thr Thr Tyr Ala Glu Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Arg Glu Gly Gly Val Ser Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 87
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 87
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Glu Ser Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 88
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp Ile Glu Ser Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Glu Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 89
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 89
Asp Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Ser Ile Glu Ser Asp 
            20                  25                  30          


Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Ser Gly Gly Asn Thr Leu Arg Pro Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gln Ser Asp Ser Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210> 90
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 90
Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 91
agcactcaga ctcaactacg                                                   20


<210> 92
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 92
His His His His His His 
1               5       


<210> 93
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (29)..(58)
<223> a, c, t, g, unknown or other

<400> 93
gggagtgtgt acgaggcatt aggccgccnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngg       60

cggctttgat acttgatcgc cctagaagc                                         89


<210> 94
<211> 228
<212> PRT
<213> Homo sapiens

<400> 94
Ile Leu Gly Gly Arg Glu Ala Glu Ala His Ala Arg Pro Tyr Met Ala 
1               5                   10                  15      


Ser Val Gln Leu Asn Gly Ala His Leu Cys Gly Gly Val Leu Val Ala 
            20                  25                  30          


Glu Gln Trp Val Leu Ser Ala Ala His Cys Leu Glu Asp Ala Ala Asp 
        35                  40                  45              


Gly Lys Val Gln Val Leu Leu Gly Ala His Ser Leu Ser Gln Pro Glu 
    50                  55                  60                  


Pro Ser Lys Arg Leu Tyr Asp Val Leu Arg Ala Val Pro His Pro Asp 
65                  70                  75                  80  


Ser Gln Pro Asp Thr Ile Asp His Asp Leu Leu Leu Leu Gln Leu Ser 
                85                  90                  95      


Glu Lys Ala Thr Leu Gly Pro Ala Val Arg Pro Leu Pro Trp Gln Arg 
            100                 105                 110         


Val Asp Arg Asp Val Ala Pro Gly Thr Leu Cys Asp Val Ala Gly Trp 
        115                 120                 125             


Gly Ile Val Asn His Ala Gly Arg Arg Pro Asp Ser Leu Gln His Val 
    130                 135                 140                 


Leu Leu Pro Val Leu Asp Arg Ala Thr Cys Asn Arg Arg Thr His His 
145                 150                 155                 160 


Asp Gly Ala Ile Thr Glu Arg Leu Met Cys Ala Glu Ser Asn Arg Arg 
                165                 170                 175     


Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Gly Gly Val 
            180                 185                 190         


Leu Glu Gly Val Val Thr Ser Gly Ser Arg Val Cys Gly Asn Arg Lys 
        195                 200                 205             


Lys Pro Gly Ile Tyr Thr Arg Val Ala Ser Tyr Ala Ala Trp Ile Asp 
    210                 215                 220                 


Ser Val Leu Ala 
225             


<210> 95
<211> 89
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (29)..(58)
<223> a, c, u, g, unknown or other

<400> 95
gggagugugu acgaggcauu aggccgccnn nnnnnnnnnn nnnnnnnnnn nnnnnnnngg       60

cggcuuugau acuugaucgc ccuagaagc                                         89



