                         SEQUENCE LISTING

<110>  Merck, Sharp & Dohme Corp.
       Gabaccio, Robert M
       Kern, Jeffrey C
       Mulhearn, James J
       Brandish, Philip E
 
<120>  PHOSPHONATE LINKERS AND THEIR USE TO FACILITATE CELLULAR 
       RETENTION OF COMPOUNDS

<130>  24291

<150>  62/288,492
<151>  2016-01-29

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  1

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  2

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  3

Gln Gln Tyr Ser Ser Ser Pro Leu Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  4

Arg Tyr Ile Ile Asn 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  5

Arg Ile Ile Pro Ile Leu Gly Val Glu Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  6

Lys Asp Trp Phe Asp Tyr 
1               5       


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  7

Arg Tyr Pro Ile Asn 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  8

Arg Ile Ile Pro Ile Leu Gly Ile Ala Asp Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  9

Arg Asp Trp Gly Asp Tyr 
1               5       


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  10

Gln Gln Tyr Gly Ser Ser Pro Ile Thr 
1               5                   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  11

Arg Tyr Ala Ile Asn 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  12

Arg Ile Ile Pro Ile Leu Asp Ile Ala Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Asp 
    


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  13

Lys Asp Trp Phe Asp Pro 
1               5       


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  14

Arg Tyr Pro Ile Asn 
1               5   


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  15

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  16

Tyr Asp Ala Ser Asn Arg Ala Thr 
1               5               


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  17

Gln Gln Arg Thr Asn Trp Pro Leu Thr 
1               5                   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  18

Ser Tyr Ile Met His 
1               5   


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  19

Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  20

Asp Thr Asp Gly Tyr Asp Phe Asp Tyr 
1               5                   


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  21

Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  22

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  23

Gln Gln Phe Asn Ser Tyr Pro Phe Thr 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  24

Tyr Tyr Ala Met His 
1               5   


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  25

Val Ile Ser Tyr Asp Gly Ser Ile Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  26

Glu Gly Pro Tyr Ser Asn Tyr Leu Asp Tyr 
1               5                   10  


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  27

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  28

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  29

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  30

Asp Tyr Gly Met His 
1               5   


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  31

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  32

Asp Ser Ile Val Met Val Arg Gly Asp Tyr 
1               5                   10  


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  33

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  34

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  35

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  36

Asp His Gly Met His 
1               5   


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  37

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  38

Asp Ser Ile Met Val Arg Gly Asp Tyr 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  39

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  40

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  41

Ser Asp Tyr Tyr Tyr Trp Ser 
1               5           


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  42

Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asp Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  43

Gly Asp Gly Asp Tyr Gly Gly Asn Cys Phe Asp Tyr 
1               5                   10          


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  44

Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  45

Thr Val Ser Asn Arg Phe Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  46

Ser Gln Ser Ser His Val Pro Pro Thr 
1               5                   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  47

Asn Tyr Gly Val Asn 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  48

Trp Ile Asn Pro Asn Thr Gly Glu Pro Thr Phe Asp Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  49

Ser Arg Gly Lys Asn Glu Ala Trp Phe Ala Tyr 
1               5                   10      


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  50

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  51

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  52

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  53

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  54
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  54

Ala Ser Gly Arg Tyr Tyr Gly Ser Gly Ser Tyr Ser Ser Tyr Phe Asp 
1               5                   10                  15      


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  55

Ile Ser Tyr Asp Gly Ser Ile Lys 
1               5               


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  56

Ala Arg Gly Arg Glu Tyr Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
1               5                   10                  15      


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  57

Ala Arg Gly Arg Glu Ile Thr Ser Gln Asn Ile Val Ile Leu Leu Asp 
1               5                   10                  15      


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  58

Ile Trp Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  59

Ala Arg Gly Gly Thr Leu Val Arg Gly Ala Met Tyr Gly Thr Asp Val 
1               5                   10                  15      


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  60

Ala Ser Gln Ser Val Ser Ser Asp Val 
1               5                   


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  61

Gln Asp Tyr Thr Ser Pro Arg Thr 
1               5               


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  62

Gly Tyr Ser Ile Thr Ser Asp Tyr 
1               5               


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  63

Cys Val Ser Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly 
1               5                   10          


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  64

Ala Ser Gln Ser Val Ser His Asp Val 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR sequence

<400>  65

Gln Asp Tyr Ser Ser Pro Arg Thr 
1               5               


<210>  66
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycosylation site atN297 of IgG1

<400>  66

Gln Tyr Asn Ser 
1               


<210>  67
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glycosylation site atN297 of IgG4

<400>  67

Gln Phe Asn Ser 
1               


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated glycosylation site of IgG1 or IgG4

<400>  68

Gln Ala Gln Ser 
1               


