                         SEQUENCE LISTING

<110>  MASSACHUSETTS INSTITUTE OF TECHNOLOGY AND STANFORD 
       UNIVERSITY
 
<120>  SYNERGISTIC TUMOR TREATMENT WITH IL-2, AN INTEGRIN-BINDING-FC 
       FUSION PROTEIN, AND A CANCER VACCINE

<130>  MITN-033PC

<150>  US 62/294,755
<151>  2016-02-12

<160>  147   

<170>  PatentIn version 3.5

<210>  1
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(330)
<223>  Human IgG1 constant region (amino acid sequence)

<400>  1

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  2
<211>  232
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(232)
<223>  Human IgG1 Fc domain (amino acid sequence)

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  3
<211>  227
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(227)
<223>  Human IgG1 Fc domain (amino acid sequence) Deletion (DEPKSC) 
       Upper Hinge

<400>  3

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  447
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(447)
<223>  Mouse IL-2 (nucleic acid sequence)

<400>  4
gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      120

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg      180

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgaact tggacctctg      240

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt      420

caaagcatca tctcaacaag ccctcaa                                          447


<210>  5
<211>  149
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(149)
<223>  Mouse IL-2 (amino acid sequence)

<400>  5

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  6
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: QQ6210 (nucleic acid sequence)

<400>  6
gcacccactt caagctccac ttcaagctct acagcggaag cacaacagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga actcctgagt      120

aggatggagg atcacaggaa cctgagactc cccaggatgc tcaccttcaa attttacttg      180

cccgagcagg ccacagaatt ggaagatctt cagtgcctag aagatgaact tgaaccactg      240

cggcaagttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgacg atgagccagc aactgtggtg gactttctga ggagatggat agccttctgt      420

caaagcatca tctcaacaag ccctcaa                                          447


<210>  7
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: QQ6210 (amino acid sequence)

<400>  7

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asp His Arg Asn Leu 
        35                  40                  45              


Arg Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Glu Gln Ala 
    50                  55                  60                  


Thr Glu Leu Glu Asp Leu Gln Cys Leu Glu Asp Glu Leu Glu Pro Leu 
65                  70                  75                  80  


Arg Gln Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Pro Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  8
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: E76A (nucleic acid sequence)

<400>  8
gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      120

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg      180

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatgctct tggacctctg      240

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt      420

caaagcatca tctcaacaag ccctcaa                                          447


<210>  9
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: E76A (amino acid sequence)

<400>  9

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Ala Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  10
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: E76G (nucleic acid sequence)

<400>  10
gcacccactt caagctccac ttcaagctct acagcggaag cacagcagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      120

aggatggaga attacaggaa cctgaaactc cccaggatgc tcaccttcaa attttacttg      180

cccaagcagg ccacagaatt gaaagatctt cagtgcctag aagatggtct tggacctctg      240

cggcatgttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgatg atgagtcagc aactgtggtg gactttctga ggagatggat agccttctgt      420

caaagcatca tctcaacaag ccctcaa                                          447


<210>  11
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: E76G (amino acid sequence)

<400>  11

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asn Tyr Arg Asn Leu 
        35                  40                  45              


Lys Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Gly Leu Gly Pro Leu 
65                  70                  75                  80  


Arg His Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Ser Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  12
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc/Flag (nucleic acid sequence)

<400>  12
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgcacgatgt       60

gagcccagag tgcccataac acagaacccc tgtcctccac tcaaagagtg tcccccatgc      120

gcagctccag acctcttggg tggaccatcc gtcttcatct tccctccaaa gatcaaggat      180

gtactcatga tctccctgag ccccatggtc acatgtgtgg tggtggccgt gagcgaggat      240

gacccagacg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca      300

caaacccata gagaggatta caacagtact ctccgggtgg tcagtgccct ccccatccag      360

caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacag agccctccca      420

tcccccatcg agaaaaccat ctcaaaaccc agagggccag taagagctcc acaggtatat      480

gtcttgcctc caccagcaga agagatgact aagaaagagt tcagtctgac ctgcatgatc      540

acaggcttct tacctgccga aattgctgtg gactggacca gcaatgggcg tacagagcaa      600

aactacaaga acaccgcaac agtcctggac tctgatggtt cttacttcat gtacagcaag      660

ctcagagtac aaaagagcac ttgggaaaga ggaagtcttt tcgcctgctc agtggtccac      720

gagggtctgc acaatcacct tacgactaag accatctccc ggtctctggg taaaggtggc      780

ggatctgact acaaggacga cgatgacaag tgataa                                816


<210>  13
<211>  270
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc/Flag (amino acid sequence)

<400>  13

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Gly Gly Gly Ser Asp Tyr Lys Asp Asp Asp Asp Lys 
            260                 265                 270 


<210>  14
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc/wt mIL-2 (nucleic acid sequence)

<400>  14
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgcacgatgt       60

gagcccagag tgcccataac acagaacccc tgtcctccac tcaaagagtg tcccccatgc      120

gcagctccag acctcttggg tggaccatcc gtcttcatct tccctccaaa gatcaaggat      180

gtactcatga tctccctgag ccccatggtc acatgtgtgg tggtggccgt gagcgaggat      240

gacccagacg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca      300

caaacccata gagaggatta caacagtact ctccgggtgg tcagtgccct ccccatccag      360

caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacag agccctccca      420

tcccccatcg agaaaaccat ctcaaaaccc agagggccag taagagctcc acaggtatat      480

gtcttgcctc caccagcaga agagatgact aagaaagagt tcagtctgac ctgcatgatc      540

acaggcttct tacctgccga aattgctgtg gactggacca gcaatgggcg tacagagcaa      600

aactacaaga acaccgcaac agtcctggac tctgatggtt cttacttcat gtacagcaag      660

ctcagagtac aaaagagcac ttgggaaaga ggaagtcttt tcgcctgctc agtggtccac      720

gagggtctgc acaatcacct tacgactaag accatctccc ggtctctggg taaaggaggg      780

ggctccgcac ccacttcaag ctccacttca agctctacag cggaagcaca gcagcagcag      840

cagcagcagc agcagcagca gcagcacctg gagcagctgt tgatggacct acaggagctc      900

ctgagcagga tggagaatta caggaacctg aaactcccca ggatgctcac cttcaaattt      960

tacttgccca agcaggccac agaattgaaa gatcttcagt gcctagaaga tgaacttgga     1020

cctctgcggc atgttctgga tttgactcaa agcaaaagct ttcaattgga agatgctgag     1080

aatttcatca gcaatatcag agtaactgtt gtaaaactaa agggctctga caacacattt     1140

gagtgccaat tcgatgatga gtcagcaact gtggtggact ttctgaggag atggatagcc     1200

ttctgtcaaa gcatcatctc aacaagccct caacaccatc accaccatca ctgataa        1257


<210>  15
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc/wt mIL-2 (amino acid sequence)

<400>  15

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser 
            260                 265                 270         


Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met 
    290                 295                 300                 


Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe 
305                 310                 315                 320 


Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu 
                325                 330                 335     


Asp Glu Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys 
            340                 345                 350         


Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val 
        355                 360                 365             


Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe 
    370                 375                 380                 


Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala 
385                 390                 395                 400 


Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln His His His His His 
                405                 410                 415     


His 
    


<210>  16
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc /QQ6210 (nucleic acid sequence)

<400>  16
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgcacgatgt       60

gagcccagag tgcccataac acagaacccc tgtcctccac tcaaagagtg tcccccatgc      120

gcagctccag acctcttggg tggaccatcc gtcttcatct tccctccaaa gatcaaggat      180

gtactcatga tctccctgag ccccatggtc acatgtgtgg tggtggccgt gagcgaggat      240

gacccagacg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca      300

caaacccata gagaggatta caacagtact ctccgggtgg tcagtgccct ccccatccag      360

caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacag agccctccca      420

tcccccatcg agaaaaccat ctcaaaaccc agagggccag taagagctcc acaggtatat      480

gtcttgcctc caccagcaga agagatgact aagaaagagt tcagtctgac ctgcatgatc      540

acaggcttct tacctgccga aattgctgtg gactggacca gcaatgggcg tacagagcaa      600

aactacaaga acaccgcaac agtcctggac tctgatggtt cttacttcat gtacagcaag      660

ctcagagtac aaaagagcac ttgggaaaga ggaagtcttt tcgcctgctc agtggtccac      720

gagggtctgc acaatcacct tacgactaag accatctccc ggtctctggg taaaggaggg      780

ggctccgcac ccacttcaag ctccacttca agctctacag cggaagcaca acagcagcag      840

cagcagcagc agcagcagca gcagcacctg gagcagctgt tgatggacct acaggaactc      900

ctgagtagga tggaggatca caggaacctg agactcccca ggatgctcac cttcaaattt      960

tacttgcccg agcaggccac agaattggaa gatcttcagt gcctagaaga tgaacttgaa     1020

ccactgcggc aagttctgga tttgactcaa agcaaaagct ttcaattgga agatgctgag     1080

aatttcatca gcaatatcag agtaactgtt gtaaaactaa agggctctga caacacattt     1140

gagtgccaat tcgacgatga gccagcaact gtggtggact ttctgaggag atggatagcc     1200

ttctgtcaaa gcatcatctc aacaagccct caacaccatc accaccatca ctgataa        1257


<210>  17
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc /QQ6210 (amino acid sequence)

<400>  17

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser 
            260                 265                 270         


Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met 
    290                 295                 300                 


Glu Asp His Arg Asn Leu Arg Leu Pro Arg Met Leu Thr Phe Lys Phe 
305                 310                 315                 320 


Tyr Leu Pro Glu Gln Ala Thr Glu Leu Glu Asp Leu Gln Cys Leu Glu 
                325                 330                 335     


Asp Glu Leu Glu Pro Leu Arg Gln Val Leu Asp Leu Thr Gln Ser Lys 
            340                 345                 350         


Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val 
        355                 360                 365             


Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe 
    370                 375                 380                 


Asp Asp Glu Pro Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala 
385                 390                 395                 400 


Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln His His His His His 
                405                 410                 415     


His 
    


<210>  18
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc / E76A (nucleic acid sequence)

<400>  18
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgcacgatgt       60

gagcccagag tgcccataac acagaacccc tgtcctccac tcaaagagtg tcccccatgc      120

gcagctccag acctcttggg tggaccatcc gtcttcatct tccctccaaa gatcaaggat      180

gtactcatga tctccctgag ccccatggtc acatgtgtgg tggtggccgt gagcgaggat      240

gacccagacg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca      300

caaacccata gagaggatta caacagtact ctccgggtgg tcagtgccct ccccatccag      360

caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacag agccctccca      420

tcccccatcg agaaaaccat ctcaaaaccc agagggccag taagagctcc acaggtatat      480

gtcttgcctc caccagcaga agagatgact aagaaagagt tcagtctgac ctgcatgatc      540

acaggcttct tacctgccga aattgctgtg gactggacca gcaatgggcg tacagagcaa      600

aactacaaga acaccgcaac agtcctggac tctgatggtt cttacttcat gtacagcaag      660

ctcagagtac aaaagagcac ttgggaaaga ggaagtcttt tcgcctgctc agtggtccac      720

gagggtctgc acaatcacct tacgactaag accatctccc ggtctctggg taaaggaggg      780

ggctccgcac ccacttcaag ctccacttca agctctacag cggaagcaca gcagcagcag      840

cagcagcagc agcagcagca gcagcacctg gagcagctgt tgatggacct acaggagctc      900

ctgagcagga tggagaatta caggaacctg aaactcccca ggatgctcac cttcaaattt      960

tacttgccca agcaggccac agaattgaaa gatcttcagt gcctagaaga tgctcttgga     1020

cctctgcggc atgttctgga tttgactcaa agcaaaagct ttcaattgga agatgctgag     1080

aatttcatca gcaatatcag agtaactgtt gtaaaactaa agggctctga caacacattt     1140

gagtgccaat tcgatgatga gtcagcaact gtggtggact ttctgaggag atggatagcc     1200

ttctgtcaaa gcatcatctc aacaagccct caacaccatc accaccatca ctgataa        1257


<210>  19
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc / E76A (amino acid sequence)

<400>  19

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser 
            260                 265                 270         


Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met 
    290                 295                 300                 


Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe 
305                 310                 315                 320 


Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu 
                325                 330                 335     


Asp Ala Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys 
            340                 345                 350         


Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val 
        355                 360                 365             


Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe 
    370                 375                 380                 


Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala 
385                 390                 395                 400 


Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln His His His His His 
                405                 410                 415     


His 
    


<210>  20
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc / E76G (nucleic acid sequence)

<400>  20
atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg tgcacgatgt       60

gagcccagag tgcccataac acagaacccc tgtcctccac tcaaagagtg tcccccatgc      120

gcagctccag acctcttggg tggaccatcc gtcttcatct tccctccaaa gatcaaggat      180

gtactcatga tctccctgag ccccatggtc acatgtgtgg tggtggccgt gagcgaggat      240

gacccagacg tccagatcag ctggtttgtg aacaacgtgg aagtacacac agctcagaca      300

caaacccata gagaggatta caacagtact ctccgggtgg tcagtgccct ccccatccag      360

caccaggact ggatgagtgg caaggagttc aaatgcaagg tcaacaacag agccctccca      420

tcccccatcg agaaaaccat ctcaaaaccc agagggccag taagagctcc acaggtatat      480

gtcttgcctc caccagcaga agagatgact aagaaagagt tcagtctgac ctgcatgatc      540

acaggcttct tacctgccga aattgctgtg gactggacca gcaatgggcg tacagagcaa      600

aactacaaga acaccgcaac agtcctggac tctgatggtt cttacttcat gtacagcaag      660

ctcagagtac aaaagagcac ttgggaaaga ggaagtcttt tcgcctgctc agtggtccac      720

gagggtctgc acaatcacct tacgactaag accatctccc ggtctctggg taaaggaggg      780

ggctccgcac ccacttcaag ctccacttca agctctacag cggaagcaca gcagcagcag      840

cagcagcagc agcagcagca gcagcacctg gagcagctgt tgatggacct acaggagctc      900

ctgagcagga tggagaatta caggaacctg aaactcccca ggatgctcac cttcaaattt      960

tacttgccca agcaggccac agaattgaaa gatcttcagt gcctagaaga tggtcttgga     1020

cctctgcggc atgttctgga tttgactcaa agcaaaagct ttcaattgga agatgctgag     1080

aatttcatca gcaatatcag agtaactgtt gtaaaactaa agggctctga caacacattt     1140

gagtgccaat tcgatgatga gtcagcaact gtggtggact ttctgaggag atggatagcc     1200

ttctgtcaaa gcatcatctc aacaagccct caacaccatc accaccatca ctgataa        1257


<210>  21
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: D265A Fc / E76G (amino acid sequence)

<400>  21

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro 
            20                  25                  30          


Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly 
        35                  40                  45              


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
    50                  55                  60                  


Ser Leu Ser Pro Met Val Thr Cys Val Val Val Ala Val Ser Glu Asp 
65                  70                  75                  80  


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
                85                  90                  95      


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
            100                 105                 110         


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
        115                 120                 125             


Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu 
    130                 135                 140                 


Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr 
145                 150                 155                 160 


Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu 
                165                 170                 175     


Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp 
            180                 185                 190         


Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val 
        195                 200                 205             


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln 
    210                 215                 220                 


Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His 
225                 230                 235                 240 


Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu 
                245                 250                 255     


Gly Lys Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser 
            260                 265                 270         


Thr Ala Glu Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


His Leu Glu Gln Leu Leu Met Asp Leu Gln Glu Leu Leu Ser Arg Met 
    290                 295                 300                 


Glu Asn Tyr Arg Asn Leu Lys Leu Pro Arg Met Leu Thr Phe Lys Phe 
305                 310                 315                 320 


Tyr Leu Pro Lys Gln Ala Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu 
                325                 330                 335     


Asp Gly Leu Gly Pro Leu Arg His Val Leu Asp Leu Thr Gln Ser Lys 
            340                 345                 350         


Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe Ile Ser Asn Ile Arg Val 
        355                 360                 365             


Thr Val Val Lys Leu Lys Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe 
    370                 375                 380                 


Asp Asp Glu Ser Ala Thr Val Val Asp Phe Leu Arg Arg Trp Ile Ala 
385                 390                 395                 400 


Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro Gln His His His His His 
                405                 410                 415     


His 
    


<210>  22
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-4 (nucleic acid sequence)

<400>  22
gcacccacct caagctccac ttcaagctct acagcggaag cacaacagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagc      120

aggatggagg attccaggaa cctgagactc cccaggatgc tcaccttcaa attttacttg      180

cccaagcagg ccacagaatt ggaagatctt cagtgcctag aagatgaact tgaacctctg      240

cggcaagttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgatg atgagccagc aactgtggtg ggctttctga ggagatggat agccttctgt      420

caaagcatca tctcaacgag ccctcaa                                          447


<210>  23
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-4 (amino acid sequence)

<400>  23

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asp Ser Arg Asn Leu 
        35                  40                  45              


Arg Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala 
    50                  55                  60                  


Thr Glu Leu Glu Asp Leu Gln Cys Leu Glu Asp Glu Leu Glu Pro Leu 
65                  70                  75                  80  


Arg Gln Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Pro Ala Thr 
        115                 120                 125             


Val Val Gly Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  24
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-8 (nucleic acid sequence)

<400>  24
gcacccacct caagctccac ttcaagctct acagcggaag cacaacagca gcagcagcag       60

cagcagcacc tggagcagct gttgatggac ctacaggagc tcctgagtag gatggaggat      120

cacaggaacc tgagactccc caggatgctc accttcaaat tttacttgcc caagcaggcc      180

acagaattgg aagatcttca gtgcctagaa gatgaacttg aacctctgcg gcaagttctg      240

gatttgactc aaagcaaaag ctttcaattg gaagatgctg agaatttcat cagcaatatc      300

agagtaactg ttgtaaaact aaagggctct gacaacacat ttgagtgcca attcgatgat      360

gagccagcaa ctgtggtgga ctttctgagg agatggatag ccttctgtca aagcatcatc      420

tcaacaagcc ctcga                                                       435


<210>  25
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-8 (amino acid sequence)

<400>  25

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu Gln 
            20                  25                  30          


Glu Leu Leu Ser Arg Met Glu Asp His Arg Asn Leu Arg Leu Pro Arg 
        35                  40                  45              


Met Leu Thr Phe Lys Phe Tyr Leu Pro Lys Gln Ala Thr Glu Leu Glu 
    50                  55                  60                  


Asp Leu Gln Cys Leu Glu Asp Glu Leu Glu Pro Leu Arg Gln Val Leu 
65                  70                  75                  80  


Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn Phe 
                85                  90                  95      


Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp Asn 
            100                 105                 110         


Thr Phe Glu Cys Gln Phe Asp Asp Glu Pro Ala Thr Val Val Asp Phe 
        115                 120                 125             


Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser Pro 
    130                 135                 140                 


Arg 
145 


<210>  26
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-10 (nucleic acid sequence)

<400>  26
gcacccacct caagctccac ttcaagctct acagcggaag cacaacagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga actcctgagt      120

aggatggagg atcacaggaa cctgagactc cccaggatgc tcaccttcaa attttacttg      180

cccgagcagg ccacagaatt ggaagatctt cagtgcctag aagatgaact tgaaccactg      240

cggcaagttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgacg atgagccagc aactgtggtg gactttctga ggagatggat agccttctgt      420

caaagcatca tctcaacaag ccctcag                                          447


<210>  27
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-10 (amino acid sequence)

<400>  27

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asp His Arg Asn Leu 
        35                  40                  45              


Arg Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Glu Gln Ala 
    50                  55                  60                  


Thr Glu Leu Glu Asp Leu Gln Cys Leu Glu Asp Glu Leu Glu Pro Leu 
65                  70                  75                  80  


Arg Gln Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Pro Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  28
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-11 (nucleic acid sequence)

<400>  28
gcacccacct caagctccac ttcaagctct acagcggaag cacaacagca gcagcagcag       60

cagcagcagc acctggagca gctgttgatg gacctacagg agctcctgag caggatggag      120

gattccagga acctgagact ccccagaatg ctcaccttca aattttactt gcccgagcag      180

gccacagaat tgaaagatct ccagtgccta gaagatgaac ttgaacctct gcggcaagtt      240

ctggatttga ctcaaagcaa aagctttcaa ttggaagatg ctgagaattt catcagcaat      300

atcagagtaa ctgttgtaaa actaaagggc tctgacaaca catttgagtg ccaattcgac      360

gatgagccag caactgtggt ggactttctg aggagatgga tagccttctg tcaaagcatc      420

atctcaacaa gccctcag                                                    438


<210>  29
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-11 (amino acid sequence)

<400>  29

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu Met Asp Leu 
            20                  25                  30          


Gln Glu Leu Leu Ser Arg Met Glu Asp Ser Arg Asn Leu Arg Leu Pro 
        35                  40                  45              


Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Glu Gln Ala Thr Glu Leu 
    50                  55                  60                  


Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Glu Pro Leu Arg Gln Val 
65                  70                  75                  80  


Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp Ala Glu Asn 
                85                  90                  95      


Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys Gly Ser Asp 
            100                 105                 110         


Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Pro Ala Thr Val Val Asp 
        115                 120                 125             


Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile Ser Thr Ser 
    130                 135                 140                 


Pro Gln 
145     


<210>  30
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-13 (nucleic acid sequence)

<400>  30
gcacccacct caagctccac ttcaagctct acagcggaag cacaacagca gcagcagcag       60

cagcagcagc agcagcagca cctggagcag ctgttgatgg acctacagga gctcctgagt      120

aggatggagg atcacaggaa cctgagactc cccaggatgc tcaccttcaa attttacttg      180

cccgagcagg ccacagaatt gaaagatctc cagtgcctag aagatgaact tgaacctctg      240

cggcaggttc tggatttgac tcaaagcaaa agctttcaat tggaagatgc tgagaatttc      300

atcagcaata tcagagtaac tgttgtaaaa ctaaagggct ctgacaacac atttgagtgc      360

caattcgatg atgagccagc aactgtggtg gactttctga ggagatggat agccttctgt      420

caaagcatca tctcaacaag ccctcag                                          447


<210>  31
<211>  149
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: mIL-2 QQ 6.2-13 (amino acid sequence)

<400>  31

Ala Pro Thr Ser Ser Ser Thr Ser Ser Ser Thr Ala Glu Ala Gln Gln 
1               5                   10                  15      


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His Leu Glu Gln Leu Leu 
            20                  25                  30          


Met Asp Leu Gln Glu Leu Leu Ser Arg Met Glu Asp His Arg Asn Leu 
        35                  40                  45              


Arg Leu Pro Arg Met Leu Thr Phe Lys Phe Tyr Leu Pro Glu Gln Ala 
    50                  55                  60                  


Thr Glu Leu Lys Asp Leu Gln Cys Leu Glu Asp Glu Leu Glu Pro Leu 
65                  70                  75                  80  


Arg Gln Val Leu Asp Leu Thr Gln Ser Lys Ser Phe Gln Leu Glu Asp 
                85                  90                  95      


Ala Glu Asn Phe Ile Ser Asn Ile Arg Val Thr Val Val Lys Leu Lys 
            100                 105                 110         


Gly Ser Asp Asn Thr Phe Glu Cys Gln Phe Asp Asp Glu Pro Ala Thr 
        115                 120                 125             


Val Val Asp Phe Leu Arg Arg Trp Ile Ala Phe Cys Gln Ser Ile Ile 
    130                 135                 140                 


Ser Thr Ser Pro Gln 
145                 


<210>  32
<211>  461
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(461)
<223>  Full length human IL-2 (nucleic acid sequence)

<400>  32
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtaatat gctgatgaga cagcaaccat tgtagaattt ctgaacagat      420

ggattacctt ttgtcaaagc atcatctcaa cactgacttg a                          461


<210>  33
<211>  153
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(153)
<223>  Full length human IL-2 (amino acid sequence)

<400>  33

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  34
<211>  401
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(401)
<223>  Human IL-2 without signal peptide (nucleic acid sequence)

<400>  34
gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat       60

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      120

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      180

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      240

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      300

acaacattca tgtgtaatat gctgatgaga cagcaaccat tgtagaattt ctgaacagat      360

ggattacctt ttgtcaaagc atcatctcaa cactgacttg a                          401


<210>  35
<211>  133
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(133)
<223>  Human IL-2 without signal peptide (amino acid sequence)

<400>  35

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  36
<211>  749
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(749)
<223>  Human serum albumin (amino acid sequence)

<400>  36

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Asp Ala His Lys Ser Glu Val Ala His 
            20                  25                  30          


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
        35                  40                  45              


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
    50                  55                  60                  


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
65                  70                  75                  80  


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
                85                  90                  95      


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
            100                 105                 110         


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
        115                 120                 125             


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
    130                 135                 140                 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
                165                 170                 175     


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
            180                 185                 190         


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
        195                 200                 205             


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
    210                 215                 220                 


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
225                 230                 235                 240 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
                245                 250                 255     


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
            260                 265                 270         


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
        275                 280                 285             


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
    290                 295                 300                 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
305                 310                 315                 320 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
                325                 330                 335     


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
            340                 345                 350         


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
        355                 360                 365             


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
    370                 375                 380                 


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
385                 390                 395                 400 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
                405                 410                 415     


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
            420                 425                 430         


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        435                 440                 445             


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
    450                 455                 460                 


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
465                 470                 475                 480 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
                485                 490                 495     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            500                 505                 510         


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 
        515                 520                 525             


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
    530                 535                 540                 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
545                 550                 555                 560 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
                565                 570                 575     


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
            580                 585                 590         


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
        595                 600                 605             


Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
    610                 615                 620                 


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
625                 630                 635                 640 


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
                645                 650                 655     


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
            660                 665                 670         


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
        675                 680                 685             


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
    690                 695                 700                 


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
705                 710                 715                 720 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
                725                 730                 735     


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly Gly Ser 
            740                 745                 


<210>  37
<211>  726
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(726)
<223>  Mature HSA (amino acid sequence)

<400>  37

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Ser Ala Pro Thr 
            580                 585                 590         


Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His Leu Leu Leu 
        595                 600                 605             


Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys 
    610                 615                 620                 


Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr 
625                 630                 635                 640 


Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu 
                645                 650                 655     


Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg 
            660                 665                 670         


Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser 
        675                 680                 685             


Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val 
    690                 695                 700                 


Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr 
705                 710                 715                 720 


Leu Thr Gly Gly Gly Ser 
                725     


<210>  38
<211>  2247
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2247)
<223>  Human serum albumin (nucleic acid sequence)

<400>  38
atggatatgc gggtgcctgc tcagctgctg ggactgctgc tgctgtggct gcctggggct       60

agatgcgccg atgctcacaa aagcgaagtc gcacacaggt tcaaagatct gggggaggaa      120

aactttaagg ctctggtgct gattgcattc gcccagtacc tgcagcagtg cccctttgag      180

gaccacgtga aactggtcaa cgaagtgact gagttcgcca agacctgcgt ggccgacgaa      240

tctgctgaga attgtgataa aagtctgcat actctgtttg gggataagct gtgtacagtg      300

gccactctgc gagaaaccta tggagagatg gcagactgct gtgccaaaca ggaacccgag      360

cggaacgaat gcttcctgca gcataaggac gataacccca atctgcctcg cctggtgcga      420

cctgaggtgg acgtcatgtg tacagccttc cacgataatg aggaaacttt tctgaagaaa      480

tacctgtacg aaatcgctcg gagacatcct tacttttatg caccagagct gctgttcttt      540

gccaaacgct acaaggccgc tttcaccgag tgctgtcagg cagccgataa agctgcatgc      600

ctgctgccta agctggacga actgagggat gagggcaagg ccagctccgc taaacagcgc      660

ctgaagtgtg ctagcctgca gaaattcggg gagcgagcct tcaaggcttg ggcagtggca      720

cggctgagtc agagattccc aaaggcagaa tttgccgagg tctcaaaact ggtgaccgac      780

ctgacaaagg tgcacaccga atgctgtcat ggcgacctgc tggagtgcgc cgacgatcga      840

gctgatctgg caaagtatat ttgtgagaac caggactcca tctctagtaa gctgaaagaa      900

tgctgtgaga aaccactgct ggaaaagtct cactgcattg ccgaagtgga gaacgacgag      960

atgccagctg atctgccctc actggccgct gacttcgtcg aaagcaaaga tgtgtgtaag     1020

aattacgctg aggcaaagga tgtgttcctg ggaatgtttc tgtacgagta tgccaggcgc     1080

cacccagact actccgtggt cctgctgctg aggctggcta aaacatatga aaccacactg     1140

gagaagtgct gtgcagccgc tgatccccat gaatgctatg ccaaagtctt cgacgagttt     1200

aagcccctgg tggaggaacc tcagaacctg atcaaacaga attgtgaact gtttgagcag     1260

ctgggcgagt acaagttcca gaacgccctg ctggtgcgct ataccaagaa agtcccacag     1320

gtgtccacac ccactctggt ggaggtgagc cggaatctgg gcaaagtggg gagtaaatgc     1380

tgtaagcacc ctgaagccaa gaggatgcca tgcgctgagg attacctgag tgtggtcctg     1440

aatcagctgt gtgtcctgca tgaaaaaaca cctgtcagcg accgggtgac aaagtgctgt     1500

actgagtcac tggtgaaccg acggccctgc tttagcgccc tggaagtcga tgagacttat     1560

gtgcctaaag agttcaacgc tgagaccttc acatttcacg cagacatttg taccctgagc     1620

gaaaaggaga gacagatcaa gaaacagaca gccctggtcg aactggtgaa gcataaaccc     1680

aaggccacaa aagagcagct gaaggctgtc atggacgatt tcgcagcctt tgtggaaaaa     1740

tgctgtaagg cagacgataa ggagacttgc tttgccgagg aaggaaagaa actggtggct     1800

gcatcccagg cagctctggg actgggagga ggatctgccc ctacctcaag ctccactaag     1860

aaaacccagc tgcagctgga gcacctgctg ctggacctgc agatgattct gaacgggatc     1920

aacaattaca aaaatccaaa gctgacccgg atgctgacat tcaagtttta tatgcccaag     1980

aaagccacag agctgaaaca cctgcagtgc ctggaggaag agctgaagcc tctggaagag     2040

gtgctgaacc tggcccagag caagaatttc catctgagac caagggatct gatctccaac     2100

attaatgtga tcgtcctgga actgaaggga tctgagacta cctttatgtg cgaatacgct     2160

gacgagactg caaccattgt ggagttcctg aacagatgga tcaccttctg ccagtccatc     2220

atttctactc tgacaggcgg ggggagc                                         2247


<210>  39
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II from Knottin Database

<400>  39

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
            20                  25              


<210>  40
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRP from Knottin Database

<400>  40

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Cys Ala Thr Cys Tyr Cys Arg Phe Phe Asn Ala Phe Cys 
            20                  25                  30          


Tyr Cys Arg Lys Leu Gly Thr Ala Met Asn Pro Cys Ser Arg Thr 
        35                  40                  45          


<210>  41
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Omega agatoxin from Knottin Database

<400>  41

Glu Asp Asn Cys Ile Ala Glu Asp Tyr Gly Lys Cys Thr Trp Gly Gly 
1               5                   10                  15      


Thr Lys Cys Cys Arg Gly Arg Pro Cys Arg Cys Ser Met Ile Gly Thr 
            20                  25                  30          


Asn Cys Glu Cys Thr Pro Arg Leu Ile Met Glu Gly Leu Ser Phe Ala 
        35                  40                  45              


<210>  42
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II Library


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is selected from the group consisting of A, V, L, P, F, Y, S, 
       H, D, and N

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is selected from the group consisting of G, V, L, P, R, E, and 
       Q

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is selected from the group consisting of G, A, and P

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is selected from the group consisting of W and N

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is selected from the group consisting of A, P, and S

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  X is selected from the group consisting of P and R

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X is selected from the group consisting of A, V, L, P, S, T, and 
       E

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  X is selected from the group consisting of G, A, W, S, T, K, and 
       E

<400>  42

Gly Cys Xaa Xaa Xaa Arg Gly Asp Xaa Xaa Xaa Xaa Xaa Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  43
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II K15S Mutation Library


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X is selected from the group consisting of A, V, L, P, F, Y, S, 
       H, D, and N

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X is selected from the group consisting of G, V, L, P, R, E, and 
       Q

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X is selected from the group consisting of G, A, and P

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X is selected from the group consisting of W and N

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X is selected from the group consisting of A, P, and S

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  X is selected from the group consisting of P and R

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X is selected from the group consisting of A, V, L, P, S, T, and 
       E

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  X is selected from the group consisting of G, A, W, S, T, K, and 
       E

<400>  43

Gly Cys Xaa Xaa Xaa Arg Gly Asp Xaa Xaa Xaa Xaa Xaa Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  44
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5F- (K15S) mIgG2aFc  Nucleic Acid Sequence

<400>  44
ggttgtccaa gaccaagagg tgataatcca ccattgactt gttctcaaga ttctgattgt       60

ttggctggtt gtgtttgtgg tccaaatggt ttttgtggtg gtcgactaga gcccagagtg      120

cccataacac agaacccctg tcctccactc aaagagtgtc ccccatgcgc agctccagac      180

ctcttgggtg gaccatccgt cttcatcttc cctccaaaga tcaaggatgt actcatgatc      240

tccctgagcc ccatggtcac atgtgtggtg gtggatgtga gcgaggatga cccagacgtc      300

cagatcagct ggtttgtgaa caacgtggaa gtacacacag ctcagacaca aacccataga      360

gaggattaca acagtactct ccgggtggtc agtgccctcc ccatccagca ccaggactgg      420

atgagtggca aggagttcaa atgcaaggtc aacaacagag ccctcccatc ccccatcgag      480

aaaaccatct caaaacccag agggccagta agagctccac aggtatatgt cttgcctcca      540

ccagcagaag agatgactaa gaaagagttc agtctgacct gcatgatcac aggcttctta      600

cctgccgaaa ttgctgtgga ctggaccagc aatgggcgta cagagcaaaa ctacaagaac      660

accgcaacag tcctggactc tgatggttct tacttcatgt acagcaagct cagagtacaa      720

aagagcactt gggaaagagg aagtcttttc gcctgctcag tggtccacga gggtctgcac      780

aatcacctta cgactaagac catctcccgg tctctgggta aa                         822


<210>  45
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5F- (K15S) mIgG2aFc  Amino Acid Sequence

<400>  45

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu Lys 
        35                  40                  45              


Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly Pro Ser Val 
    50                  55                  60                  


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
65                  70                  75                  80  


Pro Met Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
                85                  90                  95      


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
            100                 105                 110         


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
        115                 120                 125             


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
    130                 135                 140                 


Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile 
145                 150                 155                 160 


Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
                165                 170                 175     


Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu Thr Cys Met 
            180                 185                 190         


Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp Thr Ser Asn 
        195                 200                 205             


Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val Leu Asp Ser 
    210                 215                 220                 


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln Lys Ser Thr 
225                 230                 235                 240 


Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His Glu Gly Leu 
                245                 250                 255     


His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu Gly Lys 
            260                 265                 270     


<210>  46
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5D- (K15S) mIgG2aFc  Nucleic Acid Sequence

<400>  46
ggttgtccac aaggcagagg tgattgggct ccaacttctt gttctcaaga ttctgattgt       60

ttggctggtt gtgtttgtgg tccaaatggt ttttgtggtg gtcgactaga gcccagagtg      120

cccataacac agaacccctg tcctccactc aaagagtgtc ccccatgcgc agctccagac      180

ctcttgggtg gaccatccgt cttcatcttc cctccaaaga tcaaggatgt actcatgatc      240

tccctgagcc ccatggtcac atgtgtggtg gtggatgtga gcgaggatga cccagacgtc      300

cagatcagct ggtttgtgaa caacgtggaa gtacacacag ctcagacaca aacccataga      360

gaggattaca acagtactct ccgggtggtc agtgccctcc ccatccagca ccaggactgg      420

atgagtggca aggagttcaa atgcaaggtc aacaacagag ccctcccatc ccccatcgag      480

aaaaccatct caaaacccag agggccagta agagctccac aggtatatgt cttgcctcca      540

ccagcagaag agatgactaa gaaagagttc agtctgacct gcatgatcac aggcttctta      600

cctgccgaaa ttgctgtgga ctggaccagc aatgggcgta cagagcaaaa ctacaagaac      660

accgcaacag tcctggactc tgatggttct tacttcatgt acagcaagct cagagtacaa      720

aagagcactt gggaaagagg aagtcttttc gcctgctcag tggtccacga gggtctgcac      780

aatcacctta cgactaagac catctcccgg tctctgggta aa                         822


<210>  47
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5D- (K15S) mIgG2aFc  Amino Acid Sequence

<400>  47

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu Lys 
        35                  40                  45              


Glu Cys Pro Pro Cys Ala Ala Pro Asp Leu Leu Gly Gly Pro Ser Val 
    50                  55                  60                  


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
65                  70                  75                  80  


Pro Met Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
                85                  90                  95      


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
            100                 105                 110         


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
        115                 120                 125             


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
    130                 135                 140                 


Cys Lys Val Asn Asn Arg Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile 
145                 150                 155                 160 


Ser Lys Pro Arg Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
                165                 170                 175     


Pro Pro Ala Glu Glu Met Thr Lys Lys Glu Phe Ser Leu Thr Cys Met 
            180                 185                 190         


Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala Val Asp Trp Thr Ser Asn 
        195                 200                 205             


Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr Ala Thr Val Leu Asp Ser 
    210                 215                 220                 


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Gln Lys Ser Thr 
225                 230                 235                 240 


Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser Val Val His Glu Gly Leu 
                245                 250                 255     


His Asn His Leu Thr Thr Lys Thr Ile Ser Arg Ser Leu Gly Lys 
            260                 265                 270     


<210>  48
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5F- (K15S) hIgG1Fc  Amino Acid Sequence

<400>  48

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265 


<210>  49
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5F- (K15S) hIgG1Fc Fc Upper Hinge Deletion (DEPKSC) 
       Amino Acid Sequence

<400>  49

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        35                  40                  45              


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    50                  55                  60                  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
65                  70                  75                  80  


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                85                  90                  95      


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            100                 105                 110         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        115                 120                 125             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    130                 135                 140                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
145                 150                 155                 160 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                165                 170                 175     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            180                 185                 190         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        195                 200                 205             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
225                 230                 235                 240 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Pro Gly Lys 
            260 


<210>  50
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5D-  (K15S) hIgG1Fc  Amino Acid Sequence

<400>  50

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265 


<210>  51
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 2.5D- (K15S) hIgG1Fc  Fc Upper Hinge Deletion (DEPKSC)
       Amino Acid Sequence

<400>  51

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        35                  40                  45              


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    50                  55                  60                  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
65                  70                  75                  80  


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                85                  90                  95      


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            100                 105                 110         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        115                 120                 125             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    130                 135                 140                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
145                 150                 155                 160 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                165                 170                 175     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            180                 185                 190         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        195                 200                 205             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
225                 230                 235                 240 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Pro Gly Lys 
            260 


<210>  52
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hPD-1  amino acid sequence

<400>  52

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Pro Trp Asn 
            20                  25                  30          


Pro Pro Thr Phe Phe Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn 
        35                  40                  45              


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
    50                  55                  60                  


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
65                  70                  75                  80  


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
        115                 120                 125             


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu 
                165                 170                 175     


Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser 
            180                 185                 190         


Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu 
    210                 215                 220                 


Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys 
225                 230                 235                 240 


Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met 
                245                 250                 255     


Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser 
            260                 265                 270         


Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285         


<210>  53
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hPD-L-1 amino acid sequence

<400>  53

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  54
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hCTLA-4 amino acid sequence

<400>  54

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu 
            180 


<210>  55
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hLAG3 amino acid sequence

<400>  55

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  56
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hTIM3 amino acid sequence

<400>  56

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Gly Ile Tyr Ile Gly Ala Gly Ile 
        195                 200                 205             


Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe Lys 
    210                 215                 220                 


Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile Ser 
225                 230                 235                 240 


Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu Gly 
                245                 250                 255     


Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr Glu 
            260                 265                 270         


Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln Gln 
        275                 280                 285             


Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300 


<210>  57
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hB7-H3 amino acid sequence

<400>  57

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Gln Leu Asn Leu 
    50                  55                  60                  


Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala Glu 
65                  70                  75                  80  


Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro 
                85                  90                  95      


Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg 
            100                 105                 110         


Val Ala Asp Glu Gly Ser Phe Cys Phe Val Ser Ile Arg Asp Phe Gly 
        115                 120                 125             


Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
    130                 135                 140                 


Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr 
145                 150                 155                 160 


Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val Phe Trp 
                165                 170                 175     


Gln Asp 
        


<210>  58
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: hB7-H4 amino acid sequence

<400>  58

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
        35                  40                  45              


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
    50                  55                  60                  


Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
65                  70                  75                  80  


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
                85                  90                  95      


Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
            100                 105                 110         


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
        115                 120                 125             


Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu 
    130                 135                 140                 


Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser 
145                 150                 155                 160 


Pro Tyr Leu Met Leu Lys 
                165     


<210>  59
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-VEGF clone B20-4.1.1 Heavy Chain nucleic acid 
       sequence

<400>  59
atgggctggt ccctgatcct gctgttcctg gtggctgtgg ccactggcgt gcactctgaa       60

gtgcagctgg tggaatctgg cggcggactg gtgcagcctg gcggatctct gagactgagc      120

tgtgccgcca gcggcttcag catcagcggc agctggatct tctgggtgcg ccaggcccct      180

ggaaagggcc tggaatgggt gggagccatc tggccttttg gcggctacac ccactacgcc      240

gacagcgtga agggccggtt taccatcagc gccgacacca gcaagaacac cgcctacctc      300

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact attgtgccag atggggccac      360

agcacctccc cctgggccat ggattattgg ggccagggaa ccctcgtgac cgtgtcctct      420

gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggagg tacaactggc      480

tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc      540

tggaactctg gctcactgtc cagtggtgtg cacaccttcc cagctctcct ccaatctggc      600

ctctacaccc tcagcagctc agtgactgta acctcgaaca cctggcccag ccagaccatc      660

acctgcaatg tggcccaccc ggcaagcagc accaaagtgg acaagaaaat tgagcccaga      720

gtgcccataa cacagaaccc ctgtcctcca ctcaaagagt gtcccccatg cgcagctcca      780

gacctcttgg gtggaccatc cgtcttcatc ttccctccaa agatcaagga tgtactcatg      840

atctccctga gccccatggt cacatgtgtg gtggtggatg tgagcgagga tgacccagac      900

gtccagatca gctggtttgt gaacaacgtg gaagtacaca cagctcagac acaaacccat      960

agagaggatt acaacagtac tctccgggtg gtcagtgccc tccccatcca gcaccaggac     1020

tggatgagtg gcaaggagtt caaatgcaag gtcaacaaca gagccctccc atcccccatc     1080

gagaaaacca tctcaaaacc cagagggcca gtaagagctc cacaggtata tgtcttgcct     1140

ccaccagcag aagagatgac taagaaagag ttcagtctga cctgcatgat cacaggcttc     1200

ttacctgccg aaattgctgt ggactggacc agcaatgggc gtacagagca aaactacaag     1260

aacaccgcaa cagtcctgga ctctgatggt tcttacttca tgtacagcaa gctcagagta     1320

caaaagagca cttgggaaag aggaagtctt ttcgcctgct cagtggtcca cgagggtctg     1380

cacaatcacc ttacgactaa gaccatctcc cggtctctgg gtaaa                     1425


<210>  60
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-VEGF clone B20-4.1.1 Heavy Chain amino acid 
       sequence

<400>  60

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ile 
        35                  40                  45              


Ser Gly Ser Trp Ile Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Ala Ile Trp Pro Phe Gly Gly Tyr Thr His Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Trp Gly His Ser Thr Ser Pro Trp Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 


Ala Pro Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly 
145                 150                 155                 160 


Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val 
        195                 200                 205             


Thr Val Thr Ser Asn Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val 
    210                 215                 220                 


Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg 
225                 230                 235                 240 


Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro 
                245                 250                 255     


Cys Ala Ala Pro Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
            260                 265                 270         


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
    290                 295                 300                 


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
305                 310                 315                 320 


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
                325                 330                 335     


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
            340                 345                 350         


Asn Arg Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg 
        355                 360                 365             


Gly Pro Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu 
    370                 375                 380                 


Glu Met Thr Lys Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe 
385                 390                 395                 400 


Leu Pro Ala Glu Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu 
                405                 410                 415     


Gln Asn Tyr Lys Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr 
            420                 425                 430         


Phe Met Tyr Ser Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly 
        435                 440                 445             


Ser Leu Phe Ala Cys Ser Val Val His Glu Gly Leu His Asn His Leu 
    450                 455                 460                 


Thr Thr Lys Thr Ile Ser Arg Ser Leu Gly Lys 
465                 470                 475 


<210>  61
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-VEGF clone B20-4.1.1 Light Chain nucleic acid 
       sequence

<400>  61
atggacatga gagtgcccgc ccagctgctg ggacttctgc tgctgtggct gccaggcgcc       60

agatgcgaca tccagatgac ccagagcccc agcagcctgt ctgccagcgt gggcgacaga      120

gtgaccatca cctgtagagc ctctcagggc gtgcggacaa gcctggcctg gtatcagcag      180

aagcctggca aggcccccaa gctgctgatc tacgatgcca gctctctggc cagcggcgtg      240

cccagcagat tttctggcag cggctccggc accgacttca ccctgacaat cagctccctc      300

cagcccgagg acttcgccac ctactactgc cagcagagct acaagagccc cctgaccttt      360

ggccagggca ccaaggtgga aatcaagcgg gctgatgctg caccaactgt atccatcttc      420

ccaccatcca gtgagcagtt aacatctgga ggtgcctcag tcgtgtgctt cttgaacaac      480

ttctacccca aagacatcaa tgtcaagtgg aagattgatg gcagtgaacg acaaaatggc      540

gtcctgaaca gttggactga tcaggacagc aaagacagca cctacagcat gagcagcacc      600

ctcacgttga ccaaggacga gtatgaacga cataacagct atacctgtga ggccactcac      660

aagacatcaa cttcacccat tgtcaagagc ttcaacagga atgagtgt                   708


<210>  62
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-VEGF clone B20-4.1.1 Light Chain amino acid 
       sequence

<400>  62

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Val Arg Thr Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Ser Tyr Lys Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
    130                 135                 140                 


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
                165                 170                 175     


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
        195                 200                 205             


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
    210                 215                 220                 


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235     


<210>  63
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CTLA-4 clone 9D9 Heavy Chain nucleic acid 
       sequence

<400>  63
atgggctggt ccctgatcct gctgttcctg gtggctgtgg ccaccggcgt gcactctgaa       60

gccaagctcc aggaatccgg ccctgtgctc gtgaagcctg gcgcctctgt gaagatgagc      120

tgcaaggcca gcggctacac ctttaccgac tactacatga actgggtcaa gcagagccac      180

ggcaagtctc tggaatggat cggcgtgatc aacccctaca acggcgacac cagctacaac      240

cagaagttca agggcaaggc caccctgacc gtggacaaga gcagcagcac cgcctacatg      300

gaactgaaca gcctgaccag cgaggacagc gccgtgtact attgcgcccg gtactacggc      360

agttggttcg cctattgggg ccagggcacc ctgatcaccg tgtccacagc caaaacaaca      420

gccccatcgg tctatccact ggcccctgtg tgtggaggta caactggctc ctcggtgact      480

ctaggatgcc tggtcaaggg ttatttccct gagccagtga ccttgacctg gaactctggc      540

tcactgtcca gtggtgtgca caccttccca gctctcctcc aatctggcct ctacaccctc      600

agcagctcag tgactgtaac ctcgaacacc tggcccagcc agaccatcac ctgcaatgtg      660

gcccacccgg caagcagcac caaagtggac aagaaaattg agcccagagt gcccataaca      720

cagaacccct gtcctccact caaagagtgt cccccatgcg cagctccaga cctcttgggt      780

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      840

cccatggtca catgtgtggt ggtggatgtg agcgaggatg acccagacgt ccagatcagc      900

tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      960

aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc     1020

aaggagttca aatgcaaggt caacaacaga gccctcccat cccccatcga gaaaaccatc     1080

tcaaaaccca gagggccagt aagagctcca caggtatatg tcttgcctcc accagcagaa     1140

gagatgacta agaaagagtt cagtctgacc tgcatgatca caggcttctt acctgccgaa     1200

attgctgtgg actggaccag caatgggcgt acagagcaaa actacaagaa caccgcaaca     1260

gtcctggact ctgatggttc ttacttcatg tacagcaagc tcagagtaca aaagagcact     1320

tgggaaagag gaagtctttt cgcctgctca gtggtccacg agggtctgca caatcacctt     1380

acgactaaga ccatctcccg gtctctgggt aaa                                  1413


<210>  64
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CTLA-4 clone 9D9 Heavy Chain amino acid sequence

<400>  64

Met Gly Trp Ser Leu Ile Leu Leu Phe Leu Val Ala Val Ala Thr Gly 
1               5                   10                  15      


Val His Ser Glu Ala Lys Leu Gln Glu Ser Gly Pro Val Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Asn Pro Tyr Asn Gly Asp Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Tyr Tyr Gly Ser Trp Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Ile Thr Val Ser Thr Ala Lys Thr Thr Ala Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Leu 
            180                 185                 190         


Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser 
        195                 200                 205             


Asn Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Val Pro Ile Thr 
225                 230                 235                 240 


Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro 
                245                 250                 255     


Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
            260                 265                 270         


Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
    290                 295                 300                 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
305                 310                 315                 320 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
                325                 330                 335     


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu 
            340                 345                 350         


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg 
        355                 360                 365             


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys 
    370                 375                 380                 


Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu 
385                 390                 395                 400 


Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys 
                405                 410                 415     


Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
            420                 425                 430         


Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala 
        435                 440                 445             


Cys Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr 
    450                 455                 460                 


Ile Ser Arg Ser Leu Gly Lys 
465                 470     


<210>  65
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CTLA-4 clone 9D9 Light Chain nucleic acid 
       sequence

<400>  65
atggacatga gagtgcccgc ccagctgctg ggacttctgc tgctgtggct gccaggcgcc       60

agatgcgaca tcgtgatgac ccagaccacc ctgagcctgc ctgtgtccct gggagatcag      120

gccagcatca gctgtcggag cagccagagc atcgtgcaca gcaacggcaa cacctacctg      180

gaatggtatc tccagaagcc cggccagagc cccaagctgc tgatctacaa ggtgtccaac      240

cggttcagcg gcgtgcccga cagattttct ggcagcggct ccggcaccga cttcaccctg      300

aagatctccc gggtggaagc cgaggacctg ggcgtgtact actgttttca aggcagccac      360

gtgccctaca ccttcggcgg aggcaccaag ctggaaatca agcgggctga tgctgcacca      420

actgtatcca tcttcccacc atccagtgag cagttaacat ctggaggtgc ctcagtcgtg      480

tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt      540

gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac      600

agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc      660

tgtgaggcca ctcacaagac atcaacttca cccattgtca agagcttcaa caggaatgag      720

tgt                                                                    723


<210>  66
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Anti-CTLA-4 clone 9D9 Light Chain amino acid sequence

<400>  66

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Asp Ile Val Met Thr Gln Thr Thr Leu Ser 
            20                  25                  30          


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val 
            100                 105                 110         


Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile 
    130                 135                 140                 


Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val 
145                 150                 155                 160 


Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys 
                165                 170                 175     


Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr 
    210                 215                 220                 


His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
225                 230                 235                 240 


Cys 
    


<210>  67
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.4A

<400>  67

Gly Cys Ala Glu Pro Arg Gly Asp Met Pro Trp Thr Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  68
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.4B

<400>  68

Gly Cys Val Gly Gly Arg Gly Asp Trp Ser Pro Lys Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  69
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.4C

<400>  69

Gly Cys Ala Glu Leu Arg Gly Asp Arg Ser Tyr Pro Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  70
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.4E

<400>  70

Gly Cys Arg Leu Pro Arg Gly Asp Val Pro Arg Pro His Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  71
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.4H

<400>  71

Gly Cys Tyr Pro Leu Arg Gly Asp Asn Pro Tyr Ala Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  72
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.5B

<400>  72

Gly Cys Thr Ile Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  73
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 1.5F

<400>  73

Gly Cys His Pro Pro Arg Gly Asp Asn Pro Pro Val Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  74
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3A

<400>  74

Gly Cys Pro Glu Pro Arg Gly Asp Asn Pro Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  75
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3B

<400>  75

Gly Cys Leu Pro Pro Arg Gly Asp Asn Pro Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  76
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3C

<400>  76

Gly Cys His Leu Gly Arg Gly Asp Trp Ala Pro Val Gly Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  77
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3D

<400>  77

Gly Cys Asn Val Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  78
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2..3E

<400>  78

Gly Cys Phe Pro Gly Arg Gly Asp Trp Ala Pro Ser Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  79
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3F

<400>  79

Gly Cys Pro Leu Pro Arg Gly Asp Asn Pro Pro Thr Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  80
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3G

<400>  80

Gly Cys Ser Glu Ala Arg Gly Asp Asn Pro Arg Leu Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  81
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3H

<400>  81

Gly Cys Leu Leu Gly Arg Gly Asp Trp Ala Pro Glu Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Pro Asn Gly Phe Cys Gly 
            20                  25                  30          


<210>  82
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3I

<400>  82

Gly Cys His Val Gly Arg Gly Asp Trp Ala Pro Leu Lys Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  83
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.3J

<400>  83

Gly Cys Val Arg Gly Arg Gly Asp Trp Ala Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  84
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4A

<400>  84

Gly Cys Leu Gly Gly Arg Gly Asp Trp Ala Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  85
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4C

<400>  85

Gly Cys Phe Val Gly Arg Gly Asp Trp Ala Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  86
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4D

<400>  86

Gly Cys Pro Val Gly Arg Gly Asp Trp Ser Pro Ala Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  87
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4E

<400>  87

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  88
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4F

<400>  88

Gly Cys Tyr Gln Gly Arg Gly Asp Trp Ser Pro Ser Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  89
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4G

<400>  89

Gly Cys Ala Pro Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  90
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.4J

<400>  90

Gly Cys Val Gln Gly Arg Gly Asp Trp Ser Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  91
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5A

<400>  91

Gly Cys His Val Gly Arg Gly Asp Trp Ala Pro Glu Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  92
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5C

<400>  92

Gly Cys Asp Gly Gly Arg Gly Asp Trp Ala Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  93
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5D

<400>  93

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  94
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5F

<400>  94

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  95
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5D K15S Mutant

<400>  95

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  96
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5F K15S Mutant

<400>  96

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  97
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5H

<400>  97

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Glu Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  98
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: EETI-II 2.5J

<400>  98

Gly Cys Pro Arg Gly Arg Gly Asp Trp Ser Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  99
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3A

<400>  99

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Val Arg Gly Asp Trp Arg 
            20                  25                  30          


Lys Arg Cys Tyr Cys Arg 
        35              


<210>  100
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3B

<400>  100

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Glu Arg Gly Asp Met Leu 
            20                  25                  30          


Glu Lys Cys Tyr Cys Arg 
        35              


<210>  101
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3C

<400>  101

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Thr Arg Gly Asp Gly Lys 
            20                  25                  30          


Glu Lys Cys Tyr Cys Arg 
        35              


<210>  102
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3D

<400>  102

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Gln Trp Arg Gly Asp Gly Asp 
            20                  25                  30          


Val Lys Cys Tyr Cys Arg 
        35              


<210>  103
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3E

<400>  103

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Ser Arg Arg Gly Asp Met Arg 
            20                  25                  30          


Glu Arg Cys Tyr Cys Arg 
        35              


<210>  104
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3F

<400>  104

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Gln Tyr Arg Gly Asp Gly Met 
            20                  25                  30          


Lys His Cys Tyr Cys Arg 
        35              


<210>  105
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3G

<400>  105

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Thr Gly Arg Gly Asp Thr Lys 
            20                  25                  30          


Val Leu Cys Tyr Cys Arg 
        35              


<210>  106
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3H

<400>  106

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Glu Arg Gly Asp Met Lys 
            20                  25                  30          


Arg Arg Cys Tyr Cys Arg 
        35              


<210>  107
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3I

<400>  107

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Thr Gly Arg Gly Asp Val Arg 
            20                  25                  30          


Met Asn Cys Tyr Cys Arg 
        35              


<210>  108
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 3J

<400>  108

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Glu Arg Gly Asp Gly Met 
            20                  25                  30          


Ser Lys Cys Tyr Cys Arg 
        35              


<210>  109
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4A

<400>  109

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Arg Gly Arg Gly Asp Met Arg 
            20                  25                  30          


Arg Glu Cys Tyr Cys Arg 
        35              


<210>  110
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4B

<400>  110

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Val Lys 
            20                  25                  30          


Val Asn Cys Tyr Cys Arg 
        35              


<210>  111
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4C

<400>  111

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Gly Arg Gly Asp Glu Lys 
            20                  25                  30          


Met Ser Cys Tyr Cys Arg 
        35              


<210>  112
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4D

<400>  112

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Ser Arg Gly Asp Met Arg 
            20                  25                  30          


Lys Arg Cys Tyr Cys Arg 
        35              


<210>  113
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4E

<400>  113

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Arg Arg Gly Asp Ser Val 
            20                  25                  30          


Lys Lys Cys Tyr Cys Arg 
        35              


<210>  114
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4F

<400>  114

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Thr Arg 
            20                  25                  30          


Arg Arg Cys Tyr Cys Arg 
        35              


<210>  115
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4G

<400>  115

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Val Val 
            20                  25                  30          


Arg Arg Cys Tyr Cys Arg 
        35              


<210>  116
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4H

<400>  116

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Lys Gly Arg Gly Asp Asn Lys 
            20                  25                  30          


Arg Lys Cys Tyr Cys Arg 
        35              


<210>  117
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4I


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<400>  117

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Xaa Thr Cys Tyr Cys Lys Gly Arg Gly Asp Val Arg 
            20                  25                  30          


Arg Val Cys Tyr Cys Arg 
        35              


<210>  118
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 4J

<400>  118

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Gly Arg Gly Asp Asn Lys 
            20                  25                  30          


Val Lys Cys Tyr Cys Arg 
        35              


<210>  119
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5A

<400>  119

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Gly Arg Gly Asp Asn Arg 
            20                  25                  30          


Leu Lys Cys Tyr Cys Arg 
        35              


<210>  120
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5B

<400>  120

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Glu Arg Gly Asp Gly Met 
            20                  25                  30          


Lys Lys Cys Tyr Cys Arg 
        35              


<210>  121
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5C

<400>  121

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Met Arg 
            20                  25                  30          


Arg Arg Cys Tyr Cys Arg 
        35              


<210>  122
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5D

<400>  122

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Gln Gly Arg Gly Asp Gly Asp 
            20                  25                  30          


Val Lys Cys Tyr Cys Arg 
        35              


<210>  123
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5E

<400>  123

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Ser Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Val Cys Tyr Cys Arg 
        35              


<210>  124
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5F

<400>  124

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Glu Arg Gly Asp Gly Met 
            20                  25                  30          


Ile Arg Cys Tyr Cys Arg 
        35              


<210>  125
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5G

<400>  125

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Ser Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Val Cys Tyr Cys Arg 
        35              


<210>  126
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5H

<400>  126

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Met Lys 
            20                  25                  30          


Met Lys Cys Tyr Cys Arg 
        35              


<210>  127
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5I

<400>  127

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Ile Gly Arg Gly Asp Val Arg 
            20                  25                  30          


Arg Arg Cys Tyr Cys Arg 
        35              


<210>  128
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 5J

<400>  128

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Glu Arg Gly Asp Gly Arg 
            20                  25                  30          


Lys Lys Cys Tyr Cys Arg 
        35              


<210>  129
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 6B

<400>  129

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Arg Asp 
            20                  25                  30          


Met Lys Cys Tyr Cys Arg 
        35              


<210>  130
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 6C

<400>  130

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Thr Gly Arg Gly Asp Glu Lys 
            20                  25                  30          


Leu Arg Cys Tyr Cys Arg 
        35              


<210>  131
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 6E

<400>  131

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Glu Arg Gly Asp Gly Asn 
            20                  25                  30          


Arg Arg Cys Tyr Cys Arg 
        35              


<210>  132
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 6F

<400>  132

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Ser Arg Gly Asp Val Val 
            20                  25                  30          


Arg Lys Cys Tyr Cys Arg 
        35              


<210>  133
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AgRp 7C

<400>  133

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Tyr Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Arg Cys Tyr Cys Arg 
        35              


<210>  134
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (2)..(51)
<223>  "Gly Gly Gly Gly Ser" is present at least one time, but may 
       repeat up to ten times

<400>  134

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser 
    50      


<210>  135
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  135

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  136
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  136

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser 
            20      


<210>  137
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  "Gly Gly Gly Gly Ser" is present at least one time, but may 
       repeat up to six times

<400>  137

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  138
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  "Gly Gly Gly Ser" is present at least one time, but may repeat up
       to six times

<400>  138

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  


<210>  139
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: peptide

<400>  139

Glu Pro Lys Ser Cys 
1               5   


<210>  140
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (lipo-G0T10-CG)

<400>  140

Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Cys Gly 
1               5                   10          


<210>  141
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (lipo-G2T8-CG)

<400>  141

Gly Gly Thr Thr Thr Thr Thr Thr Thr Thr Cys Gly 
1               5                   10          


<210>  142
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (lipo-G4T6-CG)

<400>  142

Gly Gly Gly Gly Thr Thr Thr Thr Thr Thr Cys Gly 
1               5                   10          


<210>  143
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (lipo-G6T4-CG)

<400>  143

Gly Gly Gly Gly Gly Gly Thr Thr Thr Thr Cys Gly 
1               5                   10          


<210>  144
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (lipo-G8T2-CG)

<400>  144

Gly Gly Gly Gly Gly Gly Gly Gly Thr Thr Cys Gly 
1               5                   10          


<210>  145
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: (lipo-G10T0-CG)

<400>  145

Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Cys Gly 
1               5                   10          


<210>  146
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: tumor-associated antigen HPV E743-62

<400>  146

Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys 
1               5                   10                  15      


Cys Lys Cys Asp 
            20  


<210>  147
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: lipophilic-CpG oligonucleotide


<220>
<221>  misc_feature
<223>  Lipophilic compound, such as diacyl lipid, on 5 end

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Guanine repeat linker: At least one "g" is present and up to four
       may be absent or present

<400>  147
gggggtccat gacgttcctg acgtt                                             25


