                         SEQUENCE LISTING

<110>  Fraunhofer-Gesellschaft zur Frderung der angewandten 
       Forschung e.V.
 
<120>  Prevention of graft rejection by prior use of modified grafts

<130>  F68779PC

<150>  EP 16000373.7
<151>  2016-02-15

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Anti-CD4 Heavy Chain


<220>
<221>  CDS
<222>  (1)..(360)

<400>  1
gag gtt cag ctc cag cag tct ggg act gtg ctg gca agg cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala           
1               5                   10                  15                

tcc gtg cag atg tcc tgc aag gct tct ggc tac agc ttt gcc aac tac         96
Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr           
            20                  25                  30                    

tgg atg cac tgg gta aaa cag agg cct gga cag ggt cta caa tgg att        144
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile           
        35                  40                  45                        

ggt gct ctt tat cct gga aat gtt gat act acc tac aac cag aag ttc        192
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag gac aag gcc aaa ctg act gca gtc aca tcc gcc agc act gcc tac        240
Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc agc ctg aca aat gag gac tct gcg gtc tat tac tgt        288
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca aga atg ggt act act tta gaa gcc ccc ctt gac tat tgg ggc caa        336
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc act ctc aca gtc tcc tca                                        360
Gly Thr Thr Leu Thr Val Ser Ser                                           
        115                 120                                           


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain VH4


<220>
<221>  CDS
<222>  (1)..(360)

<400>  3
gag gtt cag ctc cag cag tct ggg act gag ctg aaa agg cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Lys Arg Pro Gly Ala           
1               5                   10                  15                

tcc gtg aag atg tcc tgc aag gct tct ggc tac acc ttt gcc aac tac         96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr           
            20                  25                  30                    

tgg atg cac tgg gta aaa cag gcc cct gga cag ggt cta caa tgg att        144
Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile           
        35                  40                  45                        

ggt gct ctt tat cct gga aat gtt gat act acc tac aac cag aag ttc        192
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag gac aag gcc aaa ctg act gca gtc aca tcc gcc agc act gcc tac        240
Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc agc ctg aca aat gag gac tct gcg gtc tat tac tgt        288
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca aga atg ggt act act tta gaa gcc ccc ctt gac tat tgg ggc caa        336
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc act gtc aca gtc tcc tca                                        360
Gly Thr Thr Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  4
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain VH3


<220>
<221>  CDS
<222>  (1)..(360)

<400>  5
gag gtt cag ctc cag cag tct ggg tct gag ctg aaa agg cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Arg Pro Gly Ala           
1               5                   10                  15                

tcc gtg aag atg tcc tgc aag gct tct ggc tac acc ttt gcc aac tac         96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr           
            20                  25                  30                    

tgg atg cac tgg gta aaa cag gcc cct gga cag ggt cta caa tgg att        144
Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile           
        35                  40                  45                        

ggt gct ctt tat cct gga aat gtt gat act acc tac aac cag aag ttc        192
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag gac aag gcc aaa ctg act gca gtc aca tcc gcc agc act gcc tac        240
Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc agc ctg aca aat gag gac acc gcg gtc tat tac tgt        288
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca aga atg ggt act act tta gaa gcc ccc ctt gac tat tgg ggc caa        336
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctt gtc aca gtc tcc tca                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  6
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain VH2


<220>
<221>  CDS
<222>  (1)..(360)

<400>  7
gag gtt cag ctc cag cag tct ggg tct gag ctg aaa agg cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Arg Pro Gly Ala           
1               5                   10                  15                

tcc gtg aag gtg tcc tgc aag gct tct ggc tac acc ttt gcc aac tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr           
            20                  25                  30                    

tgg atg cac tgg gta aaa cag gcc cct gga cag ggt cta caa tgg att        144
Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile           
        35                  40                  45                        

ggt gct ctt tat cct gga aat gtt gat act acc tac aac cag aag ttc        192
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag gac aag gcc aaa ctg act gca gac aca tcc gcc agc act gcc tac        240
Lys Asp Lys Ala Lys Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc agc ctg aca aat gag gac acc gcg gtc tat tac tgt        288
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca aga atg ggt act act tta gaa gcc ccc ctt gac tat tgg ggc caa        336
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctt gtc aca gtc tcc tca                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  8
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Leu Thr Ala Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  9
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain VH1


<220>
<221>  CDS
<222>  (1)..(360)

<400>  9
gag gtt cag ctc cag cag tct ggg tct gag ctg aaa agg cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Arg Pro Gly Ala           
1               5                   10                  15                

tcc gtg aag gtg tcc tgc aag gct tct ggc tac acc ttt gcc aac tac         96
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr           
            20                  25                  30                    

tgg atg cac tgg gta aga cag gcc cct gga cag ggt cta caa tgg att        144
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile           
        35                  40                  45                        

ggt gct ctt tat cct gga aat gtt gat act acc tac aac cag aag ttc        192
Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag gac aag gcc aaa atc act aga gac aca tcc gcc agc act gcc tac        240
Lys Asp Lys Ala Lys Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc agc agc ctg aca aat gag gac acc gcg gtc tat tac tgt        288
Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

aca aga atg ggt act act tta gaa gcc ccc ctt gac tat tgg ggc caa        336
Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggc acc ctt gtc aca gtc tcc tca                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  10
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Ala Leu Tyr Pro Gly Asn Val Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Lys Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Met Gly Thr Thr Leu Glu Ala Pro Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  11
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mouse Anti-CD4 Light Chain


<220>
<221>  CDS
<222>  (1)..(318)

<400>  11
caa att gtt ctc acc cag tct cca gca atc atg tct gca tct cca ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gtc gcc atg acc tgc agt gcc agg tca agt gta agt tac ttg         96
Glu Lys Val Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu           
            20                  25                  30                    

tac tgg tac cag cag aag cca gga tcc tcc ccc aga ctc ctg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr           
        35                  40                  45                        

gac aca tcc aac ctg gct tct gga gtc cct gtt cgc ttc att ggc agt        192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ile Gly Ser           
    50                  55                  60                            

ggg tct ggg acc tct tac tct ctc aca atc agc cga atg gag gct gaa        240
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc act tat tac tgc cag cag tgg agt gat tac ccg ctc acg        288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr           
                85                  90                  95                

ttc ggt gct ggg acc aag ctg gag ctg aaa                                318
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys                                   
            100                 105                                       


<210>  12
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  13
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain VK4


<220>
<221>  CDS
<222>  (1)..(318)

<400>  13
caa att gtt ctc acc cag tct cca gca atc ctg tct gca tct cca ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gcc gcc atg acc tgc agt gcc agg tca agt gta agt tac ttg         96
Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu           
            20                  25                  30                    

tac tgg tac cag cag aag cca ggg tcc tcc ccc aga ctc ctg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr           
        35                  40                  45                        

gac aca tcc aac ctg gct tct gga gtc cct tct cgc ttc att ggc agt        192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ile Gly Ser           
    50                  55                  60                            

ggg tct ggg acc gat tac tct ctc aca atc agc agc atg gag gct gaa        240
Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc act tat tac tgc cag cag tgg agt gat tac ccg ctc acg        288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr           
                85                  90                  95                

ttc ggt gct ggg acc aag ctg gag atc aaa                                318
Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  14
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  15
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain VK3


<220>
<221>  CDS
<222>  (1)..(318)

<400>  15
caa att gtt ctc acc cag tct cca gca acc ctg tct gca tct cca ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gcc gcc atg acc tgc agt gcc agg tca agt gta agt tac ttg         96
Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu           
            20                  25                  30                    

tac tgg tac cag cag aag cca ggg tcc tcc ccc aga ctc ctg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr           
        35                  40                  45                        

gac aca tcc aac ctg gct tct gga gtc cct tct cgc ttc att ggc agt        192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ile Gly Ser           
    50                  55                  60                            

ggg tct ggg acc gat tac tct ctc aca atc agc agc atg gag gct gaa        240
Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc act tat tac tgc cag cag tgg agt gat tac ccg ctc acg        288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr           
                85                  90                  95                

ttc ggt gct ggg acc aag ctg gag atc aaa                                318
Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  16
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ile Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  17
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain VK2


<220>
<221>  CDS
<222>  (1)..(318)

<400>  17
caa att gtt ctc acc cag tct cca gca acc ctg tct gca tct cca ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gcc gcc atg acc tgc agt gcc agg tca agt gta agt tac ttg         96
Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu           
            20                  25                  30                    

tac tgg tac cag cag aag cca ggg tcc tcc ccc aga ctc ctg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr           
        35                  40                  45                        

gac aca tcc aac ctg gct tct gga gtc cct tct cgc ttc agc ggc agt        192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggg tct ggg acc gat tac tct ctc aca atc agc agc atg gag gct gaa        240
Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc act tat tac tgc cag cag tgg agt gat tac ccg ctc acg        288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr           
                85                  90                  95                

ttc ggt gct ggg acc aag ctg gag atc aaa                                318
Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  18
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  19
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain VK1


<220>
<221>  CDS
<222>  (1)..(318)

<400>  19
caa att gtt ctc acc cag tct cca gca acc ctg tct gca tct cca ggg         48
Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly           
1               5                   10                  15                

gag aag gcc gcc atg acc tgc agt gcc agg tca agt gta agt tac ttg         96
Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu           
            20                  25                  30                    

tac tgg tac cag cag aag cca ggg tcc tcc ccc aga gcc ctg att tat        144
Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Ala Leu Ile Tyr           
        35                  40                  45                        

gac aca tcc aac ctg gct tct gga gtc cct tct cgc ttc agc ggc agt        192
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser           
    50                  55                  60                            

ggg tct ggg acc gat tac tct ctc aca atc agc agc atg gag gct gaa        240
Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu           
65                  70                  75                  80            

gat gct gcc act tat tac tgc cag cag tgg agt gat tac ccg ctc acg        288
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr           
                85                  90                  95                

ttc ggt gct ggg acc aag ctg gag atc aaa                                318
Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys                                   
            100                 105                                       


<210>  20
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Gln Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ala Ala Met Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Leu 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Ala Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     



<210>  21
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  cyclic peptide

<400>  21

Cys Asn Ser Asn Gln Ile Cys 
1               5           


