                         SEQUENCE LISTING

<110>  CAMRIS INTERNATIONAL, INC.
 
<120>  NOVEL ANTIGEN FOR USE IN MALARIA VACCINE

<130>  F8122-00008

<140>
<141>

<150>  US 62/296,464
<151>  2016-02-17

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  816
<212>  PRT
<213>  Plasmodium yoelii

<400>  1

Met Gly Asp Val Asp Asn Val Leu Ile Ser Ile Lys Lys Ile Glu Ser 
1               5                   10                  15      


Ile Lys Ser Gln Leu Asn Gln Leu Asn Lys Ile Ile Gln Asn Glu Phe 
            20                  25                  30          


Gly Ser Tyr Cys Gly Arg Lys Asn Arg Ser Ile Asn Leu Glu Ile His 
        35                  40                  45              


His Asn Glu Phe Asp Lys Ser Ile Phe Lys Arg Leu Tyr Ser Ser Trp 
    50                  55                  60                  


Arg Met Glu Asp Leu Asn Asn Phe Asn Gly Lys Ser Val Ile Lys Ile 
65                  70                  75                  80  


Met Glu Arg Asn Pro Tyr Val Ile Phe Phe Phe Phe Phe Ile Met Ile 
                85                  90                  95      


Phe Ile Ile Val Tyr Leu Ile Ser Phe Ile Leu Tyr Thr Lys Trp Phe 
            100                 105                 110         


Lys Lys Leu Leu Lys Lys Phe Ser Asn Ser His Lys Asn Asn Lys Asp 
        115                 120                 125             


Lys Glu Glu Asp Trp Val Lys Lys Asn Lys Ala Tyr Arg Asn Ser Asn 
    130                 135                 140                 


Ser Thr His Gly Thr Ile Asn Lys Asp Asn Tyr Asn Gln Glu Leu Asp 
145                 150                 155                 160 


Glu Leu His Asn Ser Asp Glu Asn Glu Glu Asn Ser Asn Val Ile Asn 
                165                 170                 175     


Ile Val Lys Lys Arg Ala Tyr Asn Leu Val Ile Asn Leu Ile Val Cys 
            180                 185                 190         


Ser Phe Leu Ile Cys Leu Ile Phe Leu Gly Ile Trp Thr Ile Phe Ile 
        195                 200                 205             


Phe Ala Asp Thr Gln Lys Gly Ile Asn Met Asn Ile Cys Gly Leu Ser 
    210                 215                 220                 


Lys Thr Val Glu Gln Phe Leu Ile Asp Lys Cys Pro Asp Thr Lys Asn 
225                 230                 235                 240 


Val Asn Pro Gln Cys Tyr Ser Leu Glu His Val Ile Asn Asp Ala Val 
                245                 250                 255     


Ser Val Met Asn Gln Tyr Gln Leu Thr Lys Glu Phe Val Lys Asn Lys 
            260                 265                 270         


Thr Asn Leu Asn Lys Asn Lys Gly Leu Pro Ile Val Leu Lys Tyr Gln 
        275                 280                 285             


Thr Gly Phe Asn Met Leu Ala Lys Leu Arg Asp Asn Ile Asp Lys Asn 
    290                 295                 300                 


Val Lys Lys Leu Glu Asn Gly Tyr Leu His Thr Tyr Pro Val Leu Thr 
305                 310                 315                 320 


Lys Leu Arg Phe Thr Leu Asp Glu Ile Val Ser Lys Gly Glu Asn Leu 
                325                 330                 335     


Leu Asn Gln Ala Glu Ser Ile Ile Asp Ser Ser Lys Glu Glu Ile Gly 
            340                 345                 350         


Lys Ile Phe Asn Asn Val Asp Asn Ala Ile Ala Asn Thr Val His Asn 
        355                 360                 365             


Asn Val Pro Ser Leu Ser Ser Lys Ile Ser Gly Leu Gly Ile Tyr Ile 
    370                 375                 380                 


Lys Lys Gln Asp Glu Asn Leu Lys Ile Arg Tyr Ile Leu Asn Lys Phe 
385                 390                 395                 400 


Thr Val Thr Met Ile Ile Leu Ser Ile Val Ile Leu Leu Phe Ser Leu 
                405                 410                 415     


Leu Val Leu Ile Gly Met Leu Ser Tyr Met Tyr Phe Leu Ile Arg Gly 
            420                 425                 430         


His Ser Ile Asn Glu Lys Phe Phe Ser Lys Leu Leu Gly Phe Phe Ser 
        435                 440                 445             


Gly Thr Phe Gly Phe Leu Ala Ile Ile Ile Leu Ile Ile Gly Thr Ala 
    450                 455                 460                 


Leu Leu Ser Leu Ser Val Leu Gly Gly Thr Ser Cys Ile Ile Ser Asp 
465                 470                 475                 480 


Arg Ile Leu Lys Asn Glu Phe Thr Phe Asp Phe Leu Ser Glu Asn Lys 
                485                 490                 495     


Ile Gly Tyr Cys Leu Gln Asn Pro Asp Glu Ser Ile Ile Asn Lys Asn 
            500                 505                 510         


Ile Val Lys Lys Tyr Ala Asn Thr Leu Asp Ser Leu Asn Thr Asn Asp 
        515                 520                 525             


Ile Tyr Asn Ser Val Glu Gly Tyr Ser Gly Tyr Phe Asp Lys Ile Lys 
    530                 535                 540                 


Asp Glu Tyr Lys Gln His Ser Lys Ile Ile Asn Glu Asn Met Trp Ile 
545                 550                 555                 560 


Ile Ile Pro Thr Asp Asn Asn Lys Tyr Val Lys Asn Val Lys Ser Asp 
                565                 570                 575     


Ile Ile Lys Lys Ser Leu Leu Gly Thr Cys Leu Thr Lys Glu Ser Ala 
            580                 585                 590         


Gln Phe Glu Glu Tyr His Leu Met Gly Thr Asp Ala Tyr Met Lys Tyr 
        595                 600                 605             


Ile Asn Lys Phe Gly Leu Leu Asn Asn Tyr Glu Met Cys Phe Glu Asp 
    610                 615                 620                 


Pro Ser Cys Glu Asn Asn Asp Arg Lys Tyr Asn Ile Asn Tyr Asn Ser 
625                 630                 635                 640 


Lys Val Thr Asp Pro Lys Tyr Leu Asp Val Lys Arg Asn Arg Val Met 
                645                 650                 655     


Leu Tyr Gln Asp Ser Asp Phe Asp Asn Val Leu Glu Val Phe Ile Leu 
            660                 665                 670         


Lys Ser Lys Ile Asn Asn Asp Lys Ile Phe Asn Ile Ser Asp Leu Asp 
        675                 680                 685             


Glu Thr Lys Lys Glu Asn Ile Thr Trp Arg Glu Tyr Thr Pro Lys Asn 
    690                 695                 700                 


Gly Ala Gly Glu Asn Lys Lys Ser Ile Val Gln Thr Tyr Phe Glu Lys 
705                 710                 715                 720 


Ala Ile Glu Tyr Met Lys Phe Glu Asn Val Leu Thr Leu Leu Lys Glu 
                725                 730                 735     


Val Asn Asn His Ile Asn Ser Phe Lys Asn Val Ile Ile Glu Lys Ala 
            740                 745                 750         


Asn Ser Leu Val Asp Asn Thr Asn Cys Ser Arg Phe Ile Asn Val Leu 
        755                 760                 765             


Thr Asn Ile Arg His Asn Tyr Cys Asp Asn Gly Ile Leu Lys Leu Thr 
    770                 775                 780                 


Arg Leu Ser Val Ile Leu Ile Ser Cys Gly Phe Val Ser Phe Cys Leu 
785                 790                 795                 800 


Trp Tyr Leu Phe Leu Phe Phe Trp Ile Tyr His Gln Met Lys Ile Ile 
                805                 810                 815     


<210>  2
<211>  2451
<212>  DNA
<213>  Plasmodium yoelii

<400>  2
atgggagacg ttgacaatgt gttaataagt atcaaaaaaa tagaatcaat aaaaagccaa       60

ttaaaccagt taaacaaaat tatacaaaat gaatttgggt cttattgtgg gcgaaaaaat      120

agaagtataa atcttgaaat acatcataat gaatttgata aaagtatatt caaacgttta      180

tattcatcat ggagaatgga agatcttaat aattttaacg ggaaaagtgt tataaaaata      240

atggaaagaa atccatatgt tatatttttt ttttttttta taatgatttt tattattgtt      300

tatttaattt catttatttt gtatactaaa tggtttaaaa aattattaaa aaaattttcg      360

aattcacaca aaaataataa agataaagaa gaagattggg taaaaaaaaa taaagcttat      420

agaaattcta atagcacaca tggtactatt aataaggata attataatca ggaacttgat      480

gagcttcata atagtgatga aaatgaagaa aatagtaatg ttataaatat tgtaaaaaag      540

agagcttata atttagtaat taatttgata gtttgttctt ttcttatttg tcttattttt      600

ttgggaattt ggacaatatt tatttttgca gatacacaaa aaggaattaa tatgaatatc      660

tgtggattat caaaaacagt tgaacagttt cttattgata aatgccccga cacaaaaaat      720

gtaaatccac aatgttattc tttagagcat gttattaatg atgctgtttc agtaatgaat      780

cagtatcaac tcaccaaaga atttgttaaa aataaaacga atttgaacaa gaataagggc      840

ttgcctattg ttttaaagta ccaaaccgga ttcaacatgc tagcaaaact tagagacaac      900

atagataaaa atgttaaaaa attagagaac ggatatcttc acacatatcc agttttaaca      960

aaacttagat ttactttgga tgaaattgtt tcgaagggag agaatctatt aaatcaggct     1020

gaatctatta ttgattcttc aaaagaagaa attggaaaaa tattcaataa tgtagataat     1080

gctatagcta atactgtaca taataatgtt ccgtctttat catcaaaaat aagtggatta     1140

ggaatatata taaaaaaaca agacgaaaat ttaaaaatac gatatatatt aaataaattt     1200

acagttacaa tgataatttt aagtatagtc atattattat tttcattact tgtgttaata     1260

ggaatgttat cttatatgta ttttttaata agaggccatt caataaatga aaaatttttt     1320

tcaaaattac ttggtttttt tagtggaaca tttggatttt tagcaattat aattttaata     1380

ataggtacgg cattattaag tttatctgtt ttgggtggaa caagttgtat tatatctgat     1440

cgaatattaa aaaatgaatt tacttttgat tttttaagcg aaaataaaat tggttattgt     1500

ttacagaatc cagatgaatc tattattaat aaaaatattg taaaaaaata tgcaaacact     1560

cttgactctt taaatacaaa tgatatatat aatagtgttg aaggctatag tggttatttt     1620

gataaaatta aggatgaata taaacaacat tctaaaatta taaatgaaaa tatgtggata     1680

attattccta cagataataa taaatatgta aaaaatgtta aatcagatat tattaaaaaa     1740

tcattattag gaacatgttt aacaaaagaa agtgcccaat ttgaagagta tcatcttatg     1800

ggaacagatg cttatatgaa atatataaat aaatttggtt tgctaaataa ttatgagatg     1860

tgttttgaag acccatcatg tgaaaataac gacagaaaat acaatatcaa ttataactct     1920

aaagttacag acccaaaata tcttgatgtt aaacgtaata gagtcatgct ttatcaagat     1980

agcgattttg ataatgtact tgaagtgttc atattaaaat caaaaattaa taatgataaa     2040

atttttaata ttagcgattt agatgaaaca aagaaggaaa atataacatg gagagaatat     2100

acaccaaaaa atggagccgg agaaaataaa aaatctattg ttcaaacata ttttgagaaa     2160

gctattgaat atatgaaatt tgaaaatgtt ttaactttac ttaaagaagt taataatcat     2220

ataaattcat ttaaaaatgt tattattgaa aaagctaatt cattagtaga taatacaaat     2280

tgtagtagat ttattaatgt actaactaat ataagacata attattgtga caatggaatt     2340

ttaaaattaa ctcgattatc agtcatactt atttcatgtg gatttgtttc cttttgtctt     2400

tggtaccttt tccttttttt ttggatatac catcaaatga agattatttg a              2451


<210>  3
<211>  791
<212>  PRT
<213>  Plasmodium falciparum

<400>  3

Met Val Asp Phe Asn Asp Leu Ser Val Glu Leu Lys Lys Thr Glu Leu 
1               5                   10                  15      


Ile Lys Glu Asp Leu Arg Asn Leu Ser His Ile Ile Asn Asn Glu Phe 
            20                  25                  30          


Ser Tyr Phe Cys Gln Asn Glu Asn Lys Asn Val Ser Phe Asn Asn Asn 
        35                  40                  45              


Ile Ser Ser Tyr Tyr Asn Asp Asp Ile Phe Ser Lys Ser Thr Leu Asn 
    50                  55                  60                  


Asn Leu Tyr Thr Ser Trp Lys Leu Glu Asp Phe Ser His Phe Asp Phe 
65                  70                  75                  80  


Ser Ser Ile Leu Asp Ile Leu Lys Arg Asn Gln Tyr Val Met Cys Ser 
                85                  90                  95      


Ile Tyr Phe Leu Leu Ile Phe Ser Cys Ile Tyr Phe Leu Thr Leu Leu 
            100                 105                 110         


Leu Tyr Thr Lys Cys Ile Lys Thr Thr Leu Lys Lys Trp Phe Cys Arg 
        115                 120                 125             


Tyr Cys Ser Glu Asn Ile Asn Glu Asn Asn Ser Asn His Asn Glu Gln 
    130                 135                 140                 


Arg Thr Val Leu Gln Asn Val Ile Asn Lys Ser Cys Tyr Phe Ile Thr 
145                 150                 155                 160 


Tyr Ser Ser Ile Ile Cys Leu Leu Leu Phe Leu Leu Leu Ser Gly Ile 
                165                 170                 175     


Thr Tyr Met His Tyr Phe Ile Lys Thr Lys Lys Gly Ile His Ser Asn 
            180                 185                 190         


Ile Cys Asn Ile Tyr Thr Arg Leu Asp Lys Phe Leu Leu Asn Lys Cys 
        195                 200                 205             


Leu Asp Pro Lys Lys Val Asp Thr Ser Cys Tyr Ser Ala Glu His Ile 
    210                 215                 220                 


Leu Asn Asp Leu Ser Ser Ile Leu Glu Glu Tyr Lys Lys Val Lys Gln 
225                 230                 235                 240 


Gln Ala Lys Asp Asp Thr Leu Leu Asp Glu Asn Thr Pro Phe Pro Leu 
                245                 250                 255     


Leu Glu Arg Tyr Ile Thr Thr Phe Asn Lys Leu Asn Val Leu Lys Asn 
            260                 265                 270         


Asn Ile Asn Lys Asn Asn Thr Thr Leu Glu Asn Glu Tyr Phe His Thr 
        275                 280                 285             


Tyr Pro Ala Leu Lys Gly Ile Ser Glu Thr Leu Thr Thr Ile Ile Ser 
    290                 295                 300                 


Glu Gly Asn Lys Asn Phe Gly Asn Ala Arg Asn Val Ile Lys Glu Val 
305                 310                 315                 320 


Lys Ser Thr Ile Lys Tyr Ser Phe His Thr Val Asp Glu Thr Ile Arg 
                325                 330                 335     


Asn Val Phe Lys Asp Ser Val Pro Lys Ile Thr Gly Leu Ile Thr Gln 
            340                 345                 350         


Ala Gly Lys Ser Ile Lys Gly Ile Asn Asn Lys Tyr Lys Ile Lys Glu 
        355                 360                 365             


Arg Ile Pro Lys Tyr Thr Asn Ile Ile Leu Leu Thr Asn Ile Ile Leu 
    370                 375                 380                 


Leu Leu Pro Pro Phe Leu Ile Leu Leu Gly Ile Ile Ile Phe Met Ile 
385                 390                 395                 400 


Phe Ile Leu Met Gly Tyr Ile Gln Lys Asn Asn Asn Phe Phe Ile Lys 
                405                 410                 415     


Leu Phe Gly His Phe Ser Ala Tyr Phe Gly Leu Leu Thr Ile Ile Ile 
            420                 425                 430         


Leu Ser Phe Gly Ile Leu Phe Leu Ser Thr Ser Val Ile Gly Gly Thr 
        435                 440                 445             


Ser Cys Ile Leu Ser Glu Arg Ile Leu Lys Asn Glu Leu Arg Phe Asp 
    450                 455                 460                 


Ile Leu Asn Asn Thr Leu Ile Asp Tyr Cys Ile Lys Asn Glu Ser Ala 
465                 470                 475                 480 


Pro Leu Ile Asp Asp Asp Ile Thr Thr Ser Phe Val Ala Lys Ile Asn 
                485                 490                 495     


Ser Phe Asp Thr Gly His Ile Asp His Asn Ile Asn Glu Tyr Glu Lys 
            500                 505                 510         


His Phe Thr Ile Leu Lys Glu Ser Phe Phe His Lys Ser Leu Lys Phe 
        515                 520                 525             


Met Asp Tyr Ile Trp Ile Val Ile Met Lys Arg Glu Asn Asn Thr Phe 
    530                 535                 540                 


Leu Asn Arg Ile Arg Thr Glu Gln Val Lys Lys Ser Leu Leu Ile Thr 
545                 550                 555                 560 


Gly Ile Ile Asn Glu Asn Ile Lys Tyr Glu Asn Met Glu Ala Ile Gly 
                565                 570                 575     


Ile Arg Ser Tyr Leu Thr Thr Leu Asn Lys Ile Ile Phe Pro Glu Asn 
            580                 585                 590         


Asn Gly Lys Ile Cys Phe Asn Asp Ile Ile Cys Glu Lys Glu Asn Asn 
        595                 600                 605             


Thr Tyr Asn Ile Thr Glu Asn Ser Lys Thr Thr Asp Gln Lys Tyr Arg 
    610                 615                 620                 


Asn Ile Arg Asp Gly Met Asp Glu His Leu Arg Asn Asp Leu Asp Ala 
625                 630                 635                 640 


Ile Val Gln Leu Phe Val Tyr Lys Ala Arg Ile Leu Lys Glu Asn Ile 
                645                 650                 655     


Phe Asp Ile Asn Asp Leu Asp Ser Asn Glu Lys Asn Lys Ile Gly Trp 
            660                 665                 670         


Ser Glu Tyr Thr Pro Arg Asn Ile Asn Gly Thr Gln Lys Lys Ser Ile 
        675                 680                 685             


Ile Asn Thr Phe Leu Val Asn Val Ile Glu Ser Ile Asn Phe Ser Glu 
    690                 695                 700                 


Ile Ile Asn Phe Phe Asp Lys Met Arg Asp Gln Phe Asn Val Leu Lys 
705                 710                 715                 720 


Asp Leu Ile Leu Leu Lys Ile Asp Thr Leu Thr Glu Asn Thr Lys Cys 
                725                 730                 735     


Asn Lys Leu Val Lys Glu Leu Ile Asn Val Arg Lys Asp Tyr Cys Asn 
            740                 745                 750         


Asn Val Val Leu Asn Leu Ser Thr Leu Ser Val Tyr Leu Ile Ile Phe 
        755                 760                 765             


Ser Ile Thr Ser Phe Leu Leu Trp Tyr Leu Phe Leu Phe Leu Trp Phe 
    770                 775                 780                 


Tyr Tyr Asn Ile Lys Pro Ser 
785                 790     


<210>  4
<211>  2375
<212>  DNA
<213>  Plasmodium falciparum

<400>  4
atggtagact tcaacgattt aagcgttgaa ctaaaaaaaa cagaattaat aaaagaggac       60

ctgagaaatc taagccatat aataaataat gaatttagtt acttttgtca aaatgaaaac      120

aagaacgtat ctttcaacaa taatattagt agttattata atgatgatat attttctaaa      180

agtacattaa ataatttata tacatcttgg aaattagaag atttttctca ttttgatttc      240

agtagtattt tagatatatt aaaaagaaat caatatgtta tgtgtagtat atatttcctc      300

ctaatttttt cttgtatcta ttttttaaca ttattattat atacaaaatg tataaaaaca      360

acgttaaaaa aatggttctg tagatattgt agtgaaaata taaatgaaaa taatagtaat      420

cataatgaac aaagaacagt attacaaaat gttataaata aatcatgtta ttttattact      480

tattcatcta taatctgtct tttattattt cttctacttt ctggaattac atatatgcat      540

tattttataa aaacaaaaaa aggaatacat tctaatattt gtaatattta tacaaggctt      600

gataaattct tattaaataa atgtctagat ccaaaaaaag ttgatacctc gtgttattca      660

gctgaacata tattgaatga tctttcttcc atattggaag aatataaaaa ggtgaagcaa      720

caagcaaagg acgacacgtt gcttgacgag aacactccct tccccctact cgaaagatac      780

attacaacgt tcaataagct aaatgtacta aaaaacaata taaataaaaa taacacaaca      840

ctcgaaaacg aatacttcca cacatatcca gccctcaaag gaatcagcga aacactaaca      900

accattatta gtgaaggcaa taaaaatttc ggaaatgcca gaaatgttat taaagaagtt      960

aaaagcacaa taaaatattc gtttcatact gttgacgaaa ccataagaaa tgtatttaaa     1020

gatagtgtac ctaaaattac aggattaata acacaagctg ggaaatctat caaaggaata     1080

aataacaaat ataaaattaa agagcgtatt cctaaatata caaatattat tttattaact     1140

aatattattt tattgttacc accattctta atattattag gtatcataat ttttatgata     1200

tttattctta tgggatatat acaaaaaaat aataatttct tcataaaatt atttggtcat     1260

ttcagtgctt actttggttt actcactata attattttat cctttggaat actattctta     1320

agtacttcag tcataggagg cacatcttgt attttatcag aaagaatttt aaaaaatgaa     1380

ttacgttttg atatattaaa taatactctt atagattatt gtattaaaaa tgaaagcgca     1440

ccattaattg acgatgatat aacaacaagc tttgtcgcta aaattaattc tttcgataca     1500

ggacatatag atcataatat aaacgaatat gaaaaacatt ttacaatttt aaaagaatct     1560

ttttttcata agtcattaaa atttatggat tatatatgga ttgttataat gaaacgagaa     1620

aataatacat ttttaaatag aataagaact gaacaagtca aaaaatcgtt attaataaca     1680

ggtattataa acgaaaatat taaatatgaa aatatggaag ctataggtat cagatcctat     1740

ttaactacgt tgaacaaaat tatttttcct gaaaataatg gtaaaatatg ttttaatgat     1800

atcatatgtg aaaaggagaa taatacatat aatattactg agaattcaaa aacaaccgat     1860

cagaaatata gaaatatacg tgatggaatg gatgaacatc ttagaaacga tttggatgct     1920

ttgttcaact ctttgtttat aaagcacgta ttctaaaaga aaatatattc gatattaacg     1980

atcttgatag taacgaaaaa aacaaaatag gatggagcga atatacaccc agaaatataa     2040

atggaacaca aaaaaaatca atcattaata ctttcctagt aaatgttatt gaaagtatta     2100

acttttcaga aataataaat ttctttgata aaatgagaga tcaatttaat gtacttaaag     2160

acctaattct attaaaaatt gatacattaa cagaaaatac aaaatgtaat aaattagtaa     2220

aagaacttat taatgtcaga aaagattatt gtaataacgt cgttttgaat ttatctactt     2280

tatctgtata tttaattata ttttccatca cttcattttt attatggtat ctatttctat     2340

tcttgtggtt ctattataat attaaaccat catag                                2375


<210>  5
<211>  2370
<212>  DNA
<213>  Plasmodium vivax

<400>  5
atgagcgacg agtacaacct gagcatcgac ctgaagaaga cggagctgct gaaggagcac       60

ttgaaagcca ttgccaaagt tatgcacaat gagttcgggt acttttgccc cagtggtgga      120

gtgaaggtcc cgcaggacca ccccaatgaa ttctcgaaga ccatatggag catcctttac      180

acgtcctgga ggatggaaga ttttacgagg ctgaatttaa aaagcgtttt gaacatcctc      240

aagaggaacc cctacgtgat ggggtgtgtg tacttcctca tcatcttcac gtgtgtatat      300

ctgttaacgt tattcctgta taccaagtgc tttcggaggt tgattaaagc cattcgttgc      360

aaaacgtgta ggaggaagaa acagaagcga gaacaacagg agagtgaaaa taaagattta      420

attgaaaatg tgaagaagcg attctttaac atcatgacgt acgtgttttt gagttcgctt      480

ctgtgtgttc tgattggttt gggcatctgg tatatgattt cttttttcaa aacgaggaat      540

gggatttata tgaatgtatg cagcgcgtcc acctcgattg agaacttcct caccgaccgc      600

tgctccgtgc agggcggcga ggtggactcg tcgtgctact ccctggagca catcgtgagc      660

gacgcggtgt ccatcgtgga gcagtaccaa gacatcaagc tgcagataaa ggcggacctg      720

ctggtggacg aggacagggc ggttccgctc ctcacaggct tcctcaccgt gttcgagaac      780

ctgaagaagc tgcagcagaa cgtggcgcgg aacaaccaca tcctggagga gcagtacttc      840

cacacgtacc ccgtgctgac gaggctgggc agagcgctcg acgcagtcat ccaggaggga      900

gaggcgaacc tccagcaggc gacaggcacc ctcgatgaag ccaagcaagc agtcaaagga      960

gccttcgaag aaatcgacca agttctggga gcaaccttta aagaaaatat ggaaaaggta     1020

aatgacaaaa ttacgctctt caataagtct ataaatagaa taatacacca gtataagata     1080

aagcaaaatt tgaagaagta cacgatttca attttgattg tgaagttggt tttgctcatt     1140

cctccccttc tcattctaat tgggttagtg cttttcatat tctttttggt gaaaggggac     1200

attggaaaca gcagtcattt ttttttggac ctctttggag tgttcagcgc ctactttgga     1260

tttttgacga tcgtcatttt gctaatcggg atagcaatgc tgagtgcgtc catcttgggg     1320

gggacgacct gcatcatcgc cgatagggtt ttaaaaaatg agctgaactt tgacgtgctg     1380

aatgataccc tgatcgatta ctgcctgaag aatgaggagt cgccccttct ctcggaggac     1440

atcaccaagg ggcttgtaga caacatgaag tctttggaca ccaccgaaat ggagaggagg     1500

gtgaatgaat acgattccta tttcaacgat atgaagagaa ccttccgcga aaatacaaga     1560

aattttgtca actacatgtg ggtggtcatt accaagccga acaacaacct gtatgtggat     1620

cgaattcggc taaacactct gaaaaagtcc ctcctagcga ccagcatcac tcgggacaat     1680

atcaaatttg gtaaattcaa cctctgggga acagatgaat actttgaaaa tctgaatcgc     1740

cactatttta ggggcaccca gtttgccctc tgctttgaaa atgaagaatg cgacagggag     1800

gaggacaagt ttaacatcaa ctttaggtcc tccataaatg accccaagta ccagaggatg     1860

aggaaccacc tcaggaataa tgatcttaga gaggacctag acaacgtggt ggagctattc     1920

atttacaagt ctagagttag gaccgaaaag atattctctg tggacgactt ggatagcagc     1980

atgacggaca aaatagggtg gagtgagtac acgccgagga ttaacaaaag ggaggggggg     2040

aaagaacaaa ccttcatttt gaggaagtac ctcgtggagg acattgaaaa tttgaacttc     2100

aaagacgtgg ttagcttctt cgagaaaatt aaacagaaat tcaacaccct cagagacacg     2160

atcattacga aggtgcagat gctcgtgaag aacaccaact gcagcagact cgttggcgag     2220

atgcacaatt tgaaacacat ctactgcgac cgagtcgtgc tgaacatgac catcctctcc     2280

gtcgcgctcg tctccttctc catcatttcg ttcttcctct ggtactgctt tttgttcttt     2340

tggctgtact accagatgaa gatgatgtga                                      2370


<210>  6
<211>  789
<212>  PRT
<213>  Plasmodium vivax

<400>  6

Met Ser Asp Glu Tyr Asn Leu Ser Ile Asp Leu Lys Lys Thr Glu Leu 
1               5                   10                  15      


Leu Lys Glu His Leu Lys Ala Ile Ala Lys Val Met His Asn Glu Phe 
            20                  25                  30          


Gly Tyr Phe Cys Pro Ser Gly Gly Val Lys Val Pro Gln Asp His Pro 
        35                  40                  45              


Asn Glu Phe Ser Lys Thr Ile Trp Ser Ile Leu Tyr Thr Ser Trp Arg 
    50                  55                  60                  


Met Glu Asp Phe Thr Arg Leu Asn Leu Lys Ser Val Leu Asn Ile Leu 
65                  70                  75                  80  


Lys Arg Asn Pro Tyr Val Met Gly Cys Val Tyr Phe Leu Ile Ile Phe 
                85                  90                  95      


Thr Cys Val Tyr Leu Leu Thr Leu Phe Leu Tyr Thr Lys Cys Phe Arg 
            100                 105                 110         


Arg Leu Ile Lys Ala Ile Arg Cys Lys Thr Cys Arg Arg Lys Lys Gln 
        115                 120                 125             


Lys Arg Glu Gln Gln Glu Ser Glu Asn Lys Asp Leu Ile Glu Asn Val 
    130                 135                 140                 


Lys Lys Arg Phe Phe Asn Ile Met Thr Tyr Val Phe Leu Ser Ser Leu 
145                 150                 155                 160 


Leu Cys Val Leu Ile Gly Leu Gly Ile Trp Tyr Met Ile Ser Phe Phe 
                165                 170                 175     


Lys Thr Arg Asn Gly Ile Tyr Met Asn Val Cys Ser Ala Ser Thr Ser 
            180                 185                 190         


Ile Glu Asn Phe Leu Thr Asp Arg Cys Ser Val Gln Gly Gly Glu Val 
        195                 200                 205             


Asp Ser Ser Cys Tyr Ser Leu Glu His Ile Val Ser Asp Ala Val Ser 
    210                 215                 220                 


Ile Val Glu Gln Tyr Gln Asp Ile Lys Leu Gln Ile Lys Ala Asp Leu 
225                 230                 235                 240 


Leu Val Asp Glu Asp Arg Ala Val Pro Leu Leu Thr Gly Phe Leu Thr 
                245                 250                 255     


Val Phe Glu Asn Leu Lys Lys Leu Gln Gln Asn Val Ala Arg Asn Asn 
            260                 265                 270         


His Ile Leu Glu Glu Gln Tyr Phe His Thr Tyr Pro Val Leu Thr Arg 
        275                 280                 285             


Leu Gly Arg Ala Leu Asp Ala Val Ile Gln Glu Gly Glu Ala Asn Leu 
    290                 295                 300                 


Gln Gln Ala Thr Gly Thr Leu Asp Glu Ala Lys Gln Ala Val Lys Gly 
305                 310                 315                 320 


Ala Phe Glu Glu Ile Asp Gln Val Leu Gly Ala Thr Phe Lys Glu Asn 
                325                 330                 335     


Met Glu Lys Val Asn Asp Lys Ile Thr Leu Phe Asn Lys Ser Ile Asn 
            340                 345                 350         


Arg Ile Ile His Gln Tyr Lys Ile Lys Gln Asn Leu Lys Lys Tyr Thr 
        355                 360                 365             


Ile Ser Ile Leu Ile Val Lys Leu Val Leu Leu Ile Pro Pro Leu Leu 
    370                 375                 380                 


Ile Leu Ile Gly Leu Val Leu Phe Ile Phe Phe Leu Val Lys Gly Asp 
385                 390                 395                 400 


Ile Gly Asn Ser Ser His Phe Phe Leu Asp Leu Phe Gly Val Phe Ser 
                405                 410                 415     


Ala Tyr Phe Gly Phe Leu Thr Ile Val Ile Leu Leu Ile Gly Ile Ala 
            420                 425                 430         


Met Leu Ser Ala Ser Ile Leu Gly Gly Thr Thr Cys Ile Ile Ala Asp 
        435                 440                 445             


Arg Val Leu Lys Asn Glu Leu Asn Phe Asp Val Leu Asn Asp Thr Leu 
    450                 455                 460                 


Ile Asp Tyr Cys Leu Lys Asn Glu Glu Ser Pro Leu Leu Ser Glu Asp 
465                 470                 475                 480 


Ile Thr Lys Gly Leu Val Asp Asn Met Lys Ser Leu Asp Thr Thr Glu 
                485                 490                 495     


Met Glu Arg Arg Val Asn Glu Tyr Asp Ser Tyr Phe Asn Asp Met Lys 
            500                 505                 510         


Arg Thr Phe Arg Glu Asn Thr Arg Asn Phe Val Asn Tyr Met Trp Val 
        515                 520                 525             


Val Ile Thr Lys Pro Asn Asn Asn Leu Tyr Val Asp Arg Ile Arg Leu 
    530                 535                 540                 


Asn Thr Leu Lys Lys Ser Leu Leu Ala Thr Ser Ile Thr Arg Asp Asn 
545                 550                 555                 560 


Ile Lys Phe Gly Lys Phe Asn Leu Trp Gly Thr Asp Glu Tyr Phe Glu 
                565                 570                 575     


Asn Leu Asn Arg His Tyr Phe Arg Gly Thr Gln Phe Ala Leu Cys Phe 
            580                 585                 590         


Glu Asn Glu Glu Cys Asp Arg Glu Glu Asp Lys Phe Asn Ile Asn Phe 
        595                 600                 605             


Arg Ser Ser Ile Asn Asp Pro Lys Tyr Gln Arg Met Arg Asn His Leu 
    610                 615                 620                 


Arg Asn Asn Asp Leu Arg Glu Asp Leu Asp Asn Val Val Glu Leu Phe 
625                 630                 635                 640 


Ile Tyr Lys Ser Arg Val Arg Thr Glu Lys Ile Phe Ser Val Asp Asp 
                645                 650                 655     


Leu Asp Ser Ser Met Thr Asp Lys Ile Gly Trp Ser Glu Tyr Thr Pro 
            660                 665                 670         


Arg Ile Asn Lys Arg Glu Gly Gly Lys Glu Gln Thr Phe Ile Leu Arg 
        675                 680                 685             


Lys Tyr Leu Val Glu Asp Ile Glu Asn Leu Asn Phe Lys Asp Val Val 
    690                 695                 700                 


Ser Phe Phe Glu Lys Ile Lys Gln Lys Phe Asn Thr Leu Arg Asp Thr 
705                 710                 715                 720 


Ile Ile Thr Lys Val Gln Met Leu Val Lys Asn Thr Asn Cys Ser Arg 
                725                 730                 735     


Leu Val Gly Glu Met His Asn Leu Lys His Ile Tyr Cys Asp Arg Val 
            740                 745                 750         


Val Leu Asn Met Thr Ile Leu Ser Val Ala Leu Val Ser Phe Ser Ile 
        755                 760                 765             


Ile Ser Phe Phe Leu Trp Tyr Cys Phe Leu Phe Phe Trp Leu Tyr Tyr 
    770                 775                 780                 


Gln Met Lys Met Met 
785                 


<210>  7
<211>  413
<212>  PRT
<213>  Plasmodium falciparum

<400>  7
Met Asn Leu Leu Val Phe Phe Cys Phe Phe Leu Leu Ser Cys Ile Val 
1               5                   10                  15      


His Leu Ser Arg Cys Ser Asp Asn Asn Ser Tyr Ser Phe Glu Ile Val 
            20                  25                  30          


Asn Arg Ser Thr Trp Leu Asn Ile Ala Glu Arg Ile Phe Lys Gly Asn 
        35                  40                  45              


Ala Pro Phe Asn Phe Thr Ile Ile Pro Tyr Asn Tyr Val Asn Asn Ser 
    50                  55                  60                  


Thr Glu Glu Asn Asn Asn Lys Asp Ser Val Leu Leu Ile Ser Lys Asn 
65                  70                  75                  80  


Leu Lys Asn Ser Ser Asn Pro Val Asp Glu Asn Asn His Ile Ile Asp 
                85                  90                  95      


Ser Thr Lys Lys Asn Thr Ser Asn Asn Asn Asn Asn Asn Ser Asn Ile 
            100                 105                 110         


Val Gly Ile Tyr Glu Ser Gln Val His Glu Glu Lys Ile Lys Glu Asp 
        115                 120                 125             


Asn Thr Arg Gln Asp Asn Ile Asn Lys Lys Glu Asn Glu Ile Ile Asn 
    130                 135                 140                 


Asn Asn His Gln Ile Pro Val Ser Asn Ile Phe Ser Glu Asn Ile Asp 
145                 150                 155                 160 


Asn Asn Lys Asn Tyr Ile Glu Ser Asn Tyr Lys Ser Thr Tyr Asn Asn 
                165                 170                 175     


Asn Pro Glu Leu Ile His Ser Thr Asp Phe Ile Gly Ser Asn Asn Asn 
            180                 185                 190         


His Thr Phe Asn Phe Leu Ser Arg Tyr Asn Asn Ser Val Leu Asn Asn 
        195                 200                 205             


Met Gln Gly Asn Thr Lys Val Pro Gly Asn Val Pro Glu Leu Lys Ala 
    210                 215                 220                 


Arg Ile Phe Ser Glu Glu Glu Asn Thr Glu Val Glu Ser Ala Glu Asn 
225                 230                 235                 240 


Asn His Thr Asn Ser Leu Asn Pro Asn Glu Ser Cys Asp Gln Ile Ile 
                245                 250                 255     


Lys Leu Gly Asp Ile Ile Asn Ser Val Asn Glu Lys Ile Ile Ser Ile 
            260                 265                 270         


Asn Ser Thr Val Asn Asn Val Leu Cys Ile Asn Leu Asp Ser Val Asn 
        275                 280                 285             


Gly Asn Gly Phe Val Trp Thr Leu Leu Gly Val His Lys Lys Lys Pro 
    290                 295                 300                 


Leu Ile Asp Pro Ser Asn Phe Pro Thr Lys Arg Val Thr Gln Ser Tyr 
305                 310                 315                 320 


Val Ser Pro Asp Ile Ser Val Thr Asn Pro Val Pro Ile Pro Lys Asn 
                325                 330                 335     


Ser Asn Thr Asn Lys Asp Asp Ser Ile Asn Asn Lys Gln Asp Gly Ser 
            340                 345                 350         


Gln Asn Asn Thr Thr Thr Asn His Phe Pro Lys Pro Arg Glu Gln Leu 
        355                 360                 365             


Val Gly Gly Ser Ser Met Leu Ile Ser Lys Ile Lys Pro His Lys Pro 
    370                 375                 380                 


Gly Lys Tyr Phe Ile Val Tyr Ser Tyr Tyr Arg Pro Phe Asp Pro Thr 
385                 390                 395                 400 


Arg Asp Thr Asn Thr Arg Ile Val Glu Leu Asn Val Gln 
                405                 410             


<210>  8
<211>  397
<212>  PRT
<213>  Plasmodium falciparum

<400>  8
Met Met Arg Lys Leu Ala Ile Leu Ser Val Ser Ser Phe Leu Phe Val 
1               5                   10                  15      


Glu Ala Leu Phe Gln Glu Tyr Gln Cys Tyr Gly Ser Ser Ser Asn Thr 
            20                  25                  30          


Arg Val Leu Asn Glu Leu Asn Tyr Asp Asn Ala Gly Thr Asn Leu Tyr 
        35                  40                  45              


Asn Glu Leu Glu Met Asn Tyr Tyr Gly Lys Gln Glu Asn Trp Tyr Ser 
    50                  55                  60                  


Leu Lys Lys Asn Ser Arg Ser Leu Gly Glu Asn Asp Asp Gly Asn Asn 
65                  70                  75                  80  


Glu Asp Asn Glu Lys Leu Arg Lys Pro Lys His Lys Lys Leu Lys Gln 
                85                  90                  95      


Pro Ala Asp Gly Asn Pro Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
            100                 105                 110         


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Val Asp Pro 
        115                 120                 125             


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    130                 135                 140                 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
145                 150                 155                 160 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                165                 170                 175     


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            180                 185                 190         


Asn Ala Asn Pro Asn Val Asp Pro Asn Ala Asn Pro Asn Ala Asn Pro 
        195                 200                 205             


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    210                 215                 220                 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
225                 230                 235                 240 


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                245                 250                 255     


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            260                 265                 270         


Asn Lys Asn Asn Gln Gly Asn Gly Gln Gly His Asn Met Pro Asn Asp 
        275                 280                 285             


Pro Asn Arg Asn Val Asp Glu Asn Ala Asn Ala Asn Ser Ala Val Lys 
    290                 295                 300                 


Asn Asn Asn Asn Glu Glu Pro Ser Asp Lys His Ile Lys Glu Tyr Leu 
305                 310                 315                 320 


Asn Lys Ile Gln Asn Ser Leu Ser Thr Glu Trp Ser Pro Cys Ser Val 
                325                 330                 335     


Thr Cys Gly Asn Gly Ile Gln Val Arg Ile Lys Pro Gly Ser Ala Asn 
            340                 345                 350         


Lys Pro Lys Asp Glu Leu Asp Tyr Ala Asn Asp Ile Glu Lys Lys Ile 
        355                 360                 365             


Cys Lys Met Glu Lys Cys Ser Ser Val Phe Asn Val Val Asn Ser Ser 
    370                 375                 380                 


Ile Gly Leu Ile Met Val Leu Ser Phe Leu Phe Leu Asn 
385                 390                 395         


<210>  9
<211>  229
<212>  PRT
<213>  Plasmodium falciparum

<400>  9
Met Lys Val Ser Lys Leu Val Leu Phe Ala His Ile Phe Phe Ile Ile 
1               5                   10                  15      


Asn Ile Leu Cys Gln Tyr Ile Cys Leu Asn Ala Ser Lys Val Asn Lys 
            20                  25                  30          


Lys Gly Lys Ile Ala Glu Glu Lys Lys Arg Lys Asn Ile Lys Asn Ile 
        35                  40                  45              


Asp Lys Ala Ile Glu Glu His Asn Lys Arg Lys Lys Leu Ile Tyr Tyr 
    50                  55                  60                  


Ser Leu Ile Ala Ser Gly Ala Ile Ala Ser Val Ala Ala Ile Leu Gly 
65                  70                  75                  80  


Leu Gly Tyr Tyr Gly Tyr Lys Lys Ser Arg Glu Asp Asp Leu Tyr Tyr 
                85                  90                  95      


Asn Lys Tyr Leu Glu Tyr Arg Asn Gly Glu Tyr Asn Ile Lys Tyr Gln 
            100                 105                 110         


Asp Gly Ala Ile Ala Ser Thr Ser Glu Phe Tyr Ile Glu Pro Glu Gly 
        115                 120                 125             


Ile Asn Lys Ile Asn Leu Asn Lys Pro Ile Ile Glu Asn Lys Asn Asn 
    130                 135                 140                 


Val Asp Val Ser Ile Lys Arg Tyr Asn Asn Phe Val Asp Ile Ala Arg 
145                 150                 155                 160 


Leu Ser Ile Gln Lys His Phe Glu His Leu Ser Asn Asp Gln Lys Asp 
                165                 170                 175     


Ser His Val Asn Asn Met Glu Tyr Met Gln Lys Phe Val Gln Gly Leu 
            180                 185                 190         


Gln Glu Asn Arg Asn Ile Ser Leu Ser Lys Tyr Gln Glu Asn Lys Ala 
        195                 200                 205             


Val Met Asp Leu Lys Tyr His Leu Gln Lys Val Tyr Ala Asn Tyr Leu 
    210                 215                 220                 


Ser Gln Glu Glu Asn 
225                 


