                         SEQUENCE LISTING

<110>  Inserm
 
<120>  ANTIBODIES HAVING SPECIFICITY FOR BTLA AND USES THEREOF

<130>  BIO15432 OLIVE / MC

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH sequence of 629.3

<400>  1

Gln Val Gln Leu Arg Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Asn Thr Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Val Trp Gly Asp Gly Asn Thr Asn Tyr His Ser Val Val Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Leu Asn Ser Leu Gln Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Cys Tyr Gly Ser Arg Phe Asp Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence of 629.3

<400>  2

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ile Gly 
1               5                   10                  15      


Glu Gln Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys 
            100                 105                 110         


<210>  3
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA VH Region of the 629.3 mAb

<400>  3
caggtgcagc tgagggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acgtgcactg tctcagggtt ctcattaaac acctatggtg taagttgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagta gtatggggtg acgggaacac aaattatcat      180

tcagttgtca tatccagact gaccatcaat aaggataatt ccaagagcca agttttctta      240

aaactgaaca gtctgcaaac tgatgacaca gccacgtact actgtgccaa atgctacggt      300

agtaggttcg actacgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  4
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA VL region of the 629.3 mAb

<400>  4
gacattgtga tgtcacagtc tccatcttcc ctggctgtgt caataggaga gcaggtcact       60

atgagctgca aatccagtca gagtctgctc agcagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agagaccagg acagtctcct aaactgctga tctactgggc atccactcgg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

ccgacgttcg gtggaggcac caggctggaa atcaaa                                336


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:5

<400>  5

Val Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn 
1               5                   10                  15  


<210>  6
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:6

<400>  6

Pro Ser Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu 
1               5                   10              


<210>  7
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:7

<400>  7

Met Lys Thr Leu Pro Ala Met Leu Gly Thr Gly Lys Leu Phe Trp Val 
1               5                   10                  15      


Phe Phe Leu Ile Pro Tyr Leu Asp Ile Trp Asn Ile His Gly Lys Glu 
            20                  25                  30          


Ser Cys Asp Val Gln Leu Tyr Ile Lys Arg Gln Ser Glu His Ser Ile 
        35                  40                  45              


Leu Ala Gly Asp Pro Phe Glu Leu Glu Cys Pro Val Lys Tyr Cys Ala 
    50                  55                  60                  


Asn Arg Pro His Val Thr Trp Cys Lys Leu Asn Gly Thr Thr Cys Val 
65                  70                  75                  80  


Lys Leu Glu Asp Arg Gln Thr Ser Trp Lys Glu Glu Lys Asn Ile Ser 
                85                  90                  95      


Phe Phe Ile Leu His Phe Glu Pro Val Leu Pro Asn Asp Asn Gly Ser 
            100                 105                 110         


Tyr Arg Cys Ser Ala Asn Phe Gln Ser Asn Leu Ile Glu Ser His Ser 
        115                 120                 125             


Thr Thr Leu Tyr Val Thr Asp Val Lys Ser Ala Ser Glu Arg Pro Ser 
    130                 135                 140                 


Lys Asp Glu Met Ala Ser Arg Pro Trp Leu Leu Tyr Arg Leu Leu Pro 
145                 150                 155                 160 


Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys Leu Phe Cys 
                165                 170                 175     


Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala 
            180                 185                 190         


Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr 
        195                 200                 205             


Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly 
    210                 215                 220                 


Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser 
225                 230                 235                 240 


Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val 
                245                 250                 255     


Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala 
            260                 265                 270         


Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg 
        275                 280                 285             


Ser 
    


