                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       French, Brent
 
<120>  COMPOSITIONS AND METHODS FOR ADENO-ASSOCIATED VIRUS MEDIATED GENE
        EXPRESS IN MYOFIBROBLAST-LIKE CELLS

<130>  02245-02

<150>  US 62/301,985
<151>  2016-03-01

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  4385
<212>  DNA
<213>  adeno-associated virus 9

<400>  1
cagagaggga gtggccaact ccatcactag gggtaatcgc gaagcgcctc ccacgctgcc       60

gcgtcagcgc tgacgtagat tacgtcatag gggagtggtc ctgtattagc tgtcacgtga      120

gtgcttttgc gacattttgc gacaccacat ggccatttga ggtatatatg gccgagtgag      180

cgagcaggat ctccattttg accgcgaaat ttgaacgagc agcagccatg ccgggcttct      240

acgagattgt gatcaaggtg ccgagcgacc tggacgagca cctgccgggc atttctgact      300

cttttgtgaa ctgggtggcc gagaaggaat gggagctgcc cccggattct gacatggatc      360

ggaatctgat cgagcaggca cccctgaccg tggccgagaa gctgcagcgc gacttcctgg      420

tccaatggcg ccgcgtgagt aaggccccgg aggccctctt ctttgttcag ttcgagaagg      480

gcgagagcta ctttcacctg cacgttctgg tcgagaccac gggggtcaag tccatggtgc      540

taggccgctt cctgagtcag attcgggaga agctggtcca gaccatctac cgcgggatcg      600

agccgaccct gcccaactgg ttcgcggtga ccaagacgcg taatggcgcc ggcgggggga      660

acaaggtggt ggacgagtgc tacatcccca actacctcct gcccaagact cagcccgagc      720

tgcagtgggc gtggactaac atggaggagt atataagcgc gtgcttgaac ctggccgagc      780

gcaaacggct cgtggcgcag cacctgaccc acgtcagcca gacgcaggag cagaacaagg      840

agaatctgaa ccccaattct gacgcgcccg tgatcaggtc aaaaacctcc gcgcgctaca      900

tggagctggt cgggtggctg gtggaccggg gcatcacctc cgagaagcag tggatccagg      960

aggaccaggc ctcgtacatc tccttcaacg ccgcctccaa ctcgcggtcc cagatcaagg     1020

ccgcgctgga caatgccggc aagatcatgg cgctgaccaa atccgcgccc gactacctgg     1080

taggcccttc acttccggtg gacattacgc agaaccgcat ctaccgcatc ctgcagctca     1140

acggctacga ccctgcctac gccggctccg tctttctcgg ctgggcacaa aagaagttcg     1200

ggaaacgcaa caccatctgg ctgtttgggc cggccaccac gggaaagacc aacatcgcag     1260

aagccattgc ccacgccgtg cccttctacg gctgcgtcaa ctggaccaat gagaactttc     1320

ccttcaacga ttgcgtcgac aagatggtga tctggtggga ggagggcaag atgacggcca     1380

aggtcgtgga gtccgccaag gccattctcg gcggcagcaa ggtgcgcgtg gaccaaaagt     1440

gcaagtcgtc cgcccagatc gaccccactc ccgtgatcgt cacctccaac accaacatgt     1500

gcgccgtgat tgacgggaac agcaccacct tcgagcacca gcagcctctc caggaccgga     1560

tgtttaagtt cgaactcacc cgccgtctgg agcacgactt tggcaaggtg acaaagcagg     1620

aagtcaaaga gttcttccgc tgggccagtg atcacgtgac cgaggtggcg catgagtttt     1680

acgtcagaaa gggcggagcc agcaaaagac ccgcccccga tgacgcggat aaaagcgagc     1740

ccaagcgggc ctgcccctca gtcgcggatc catcgacgtc agacgcggaa ggagctccgg     1800

tggactttgc cgacaggtac caaaacaaat gttctcgtca cgcgggcatg cttcagatgc     1860

tgcttccctg caaaacgtgc gagagaatga atcagaattt caacatttgc ttcacacacg     1920

gggtcagaga ctgctcagag tgtttccccg gcgtgtcaga atctcaaccg gtcgtcagaa     1980

agaggacgta tcggaaactc tgtgcgattc atcatctgct ggggcgggct cccgagattg     2040

cttgctcggc ctgcgatctg gtcaacgtgg acctggatga ctgtgtttct gagcaataaa     2100

tgacttaaac caggtatggc tgccgatggt tatcttccag attggctcga ggacaacctc     2160

tctgagggca ttcgcgagtg gtgggcgctg aaacctggag ccccgaagcc caaagccaac     2220

cagcaaaagc aggacgacgg ccggggtctg gtgcttcctg gctacaagta cctcggaccc     2280

ttcaacggac tcgacaaggg ggagcccgtc aacgcggcgg acgcagcggc cctcgagcac     2340

ggcaaggcct acgaccagca gctgcaggcg ggtgacaatc cgtacctgcg gtataaccac     2400

gccgacgccg agtttcagga gcgtctgcaa gaagatacgt cttttggggg caacctcggg     2460

cgagcagtct tccaggccaa gaagcgggtt ctcgaacctc tcggtctggt tgaggaaggc     2520

gctaagacgg ctcctggaaa gaagagaccg gtagagccat caccccagcg ttctccagac     2580

tcctctacgg gcatcggcaa gaaaggccaa cagcccgcca gaaaaagact caattttggt     2640

cagactggcg actcagagtc agttccagac cctcaacctc tcggagaacc tccagcagcg     2700

ccctctggtg tgggacctaa tacaatggct gcaggcggtg gcgcaccaat ggcagacaat     2760

aacgaaggcg ccgacggagt gggtaattcc tcgggaaatt ggcattgcga ttccacatgg     2820

ctgggggaca gagtcatcac caccagcacc cgaacctggg cattgcccac ctacaacaac     2880

cacctctaca agcaaatctc caatggaaca tcgggaggaa gcaccaacga caacacctac     2940

tttggctaca gcaccccctg ggggtatttt gacttcaaca gattccactg ccacttctca     3000

ccacgtgact ggcagcgact catcaacaac aactggggat tccggccaaa gagactcaac     3060

ttcaagctgt tcaacatcca ggtcaaggag gttacgacga acgaaggcac caagaccatc     3120

gccaataacc ttaccagcac cgtccaggtc tttacggact cggagtacca gctaccgtac     3180

gtcctaggct ctgcccacca aggatgcctg ccaccgtttc ctgcagacgt cttcatggtt     3240

cctcagtacg gctacctgac gctcaacaat ggaagtcaag cgttaggacg ttcttctttc     3300

tactgtctgg aatacttccc ttctcagatg ctgagaaccg gcaacaactt tcagttcagc     3360

tacactttcg aggacgtgcc tttccacagc agctacgcac acagccagag tctagatcga     3420

ctgatgaacc ccctcatcga ccagtaccta tactacctgg tcagaacaca gacaactgga     3480

actgggggaa ctcaaacttt ggcattcagc caagcaggcc ctagctcaat ggccaatcag     3540

gctagaaact gggtacccgg gccttgctac cgtcagcagc gcgtctccac aaccaccaac     3600

caaaataaca acagcaactt tgcgtggacg ggagctgcta aattcaagct gaacgggaga     3660

gactcgctaa tgaatcctgg cgtggctatg gcatcgcaca aagacgacga ggaccgcttc     3720

tttccatcaa gtggcgttct catatttggc aagcaaggag ccgggaacga tggagtcgac     3780

tacagccagg tgctgattac agatgaggaa gaaattaaag ccaccaaccc tgtagccaca     3840

gaggaatacg gagcagtggc catcaacaac caggccgcta acacgcaggc gcaaactgga     3900

cttgtgcata accagggagt tattcctggt atggtctggc agaaccggga cgtgtacctg     3960

cagggcccta tttgggctaa aatacctcac acagatggca actttcaccc gtctcctctg     4020

atgggtggat ttggactgaa acacccacct ccacagattc taattaaaaa tacaccagtg     4080

ccggcagatc ctcctcttac cttcaatcaa gccaagctga actctttcat cacgcagtac     4140

agcacgggac aagtcagcgt ggaaatcgag tgggagctgc agaaagaaaa cagcaagcgc     4200

tggaatccag agatccagta tacttcaaac tactacaaat ctacaaatgt ggactttgct     4260

gtcaatacca aaggtgttta ctctgagcct cgccccattg gtactcgtta cctcacccgt     4320

aatttgtaat tgcctgttaa tcaataaacc ggttaattcg tttcagttga actttggtct     4380

ctgcg                                                                 4385


<210>  2
<211>  4393
<212>  DNA
<213>  adeno-associated virus 8

<400>  2
cagagaggga gtggccaact ccatcactag gggtagcgcg aagcgcctcc cacgctgccg       60

cgtcagcgct gacgtaaatt acgtcatagg ggagtggtcc tgtattagct gtcacgtgag      120

tgcttttgcg gcattttgcg acaccacgtg gccatttgag gtatatatgg ccgagtgagc      180

gagcaggatc tccattttga ccgcgaaatt tgaacgagca gcagccatgc cgggcttcta      240

cgagatcgtg atcaaggtgc cgagcgacct ggacgagcac ctgccgggca tttctgactc      300

gtttgtgaac tgggtggccg agaaggaatg ggagctgccc ccggattctg acatggatcg      360

gaatctgatc gagcaggcac ccctgaccgt ggccgagaag ctgcagcgcg acttcctggt      420

ccaatggcgc cgcgtgagta aggccccgga ggccctcttc tttgttcagt tcgagaaggg      480

cgagagctac tttcacctgc acgttctggt cgagaccacg ggggtcaagt ccatggtgct      540

aggccgcttc ctgagtcaga ttcgggaaaa gcttggtcca gaccatctac ccgcggggtc      600

gagccccacc ttgcccaact ggttcgcggt gaccaaagac gcggtaatgg cgccggcggg      660

ggggaacaag gtggtggacg agtgctacat ccccaactac ctcctgccca agactcagcc      720

cgagctgcag tgggcgtgga ctaacatgga ggagtatata agcgcgtgct tgaacctggc      780

cgagcgcaaa cggctcgtgg cgcagcacct gacccacgtc agccagacgc aggagcagaa      840

caaggagaat ctgaacccca attctgacgc gcccgtgatc aggtcaaaaa cctccgcgcg      900

ctatatggag ctggtcgggt ggctggtgga ccggggcatc acctccgaga agcagtggat      960

ccaggaggac caggcctcgt acatctcctt caacgccgcc tccaactcgc ggtcccagat     1020

caaggccgcg ctggacaatg ccggcaagat catggcgctg accaaatccg cgcccgacta     1080

cctggtgggg ccctcgctgc ccgcggacat tacccagaac cgcatctacc gcatcctcgc     1140

tctcaacggc tacgaccctg cctacgccgg ctccgtcttt ctcggctggg ctcagaaaaa     1200

gttcgggaaa cgcaacacca tctggctgtt tggacccgcc accaccggca agaccaacat     1260

tgcggaagcc atcgcccacg ccgtgccctt ctacggctgc gtcaactgga ccaatgagaa     1320

ctttcccttc aatgattgcg tcgacaagat ggtgatctgg tgggaggagg gcaagatgac     1380

ggccaaggtc gtggagtccg ccaaggccat tctcggcggc agcaaggtgc gcgtggacca     1440

aaagtgcaag tcgtccgccc agatcgaccc cacccccgtg atcgtcacct ccaacaccaa     1500

catgtgcgcc gtgattgacg ggaacagcac caccttcgag caccagcagc ctctccagga     1560

ccggatgttt aagttcgaac tcacccgccg tctggagcac gactttggca aggtgacaaa     1620

gcaggaagtc aaagagttct tccgctgggc cagtgatcac gtgaccgagg tggcgcatga     1680

gttttacgtc agaaagggcg gagccagcaa aagacccgcc cccgatgacg cggataaaag     1740

cgagcccaag cgggcctgcc cctcagtcgc ggatccatcg acgtcagacg cggaaggagc     1800

tccggtggac tttgccgaca ggtaccaaaa caaatgttct cgtcacgcgg gcatgcttca     1860

gatgctgttt ccctgcaaaa cgtgcgagag aatgaatcag aatttcaaca tttgcttcac     1920

acacggggtc agagactgct cagagtgttt ccccggcgtg tcagaatctc aaccggtcgt     1980

cagaaagagg acgtatcgga aactctgtgc gattcatcat ctgctggggc gggctcccga     2040

gattgcttgc tcggcctgcg atctggtcaa cgtggacctg gatgactgtg tttctgagca     2100

ataaatgact taaaccaggt atggctgccg atggttatct tccagattgg ctcgaggaca     2160

acctctctga gggcattcgc gagtggtggg cgctgaaacc tggagccccg aagcccaaag     2220

ccaaccagca aaagcaggac gacggccggg gtctggtgct tcctggctac aagtacctcg     2280

gacccttcaa cggactcgac aagggggagc ccgtcaacgc ggcggacgca gcggccctcg     2340

agcacgacaa ggcctacgac cagcagctgc aggcgggtga caatccgtac ctgcggtata     2400

accacgccga cgccgagttt caggagcgtc tgcaagaaga tacgtctttt gggggcaacc     2460

tcgggcgagc agtcttccag gccaagaagc gggttctcga acctctcggt ctggttgagg     2520

aaggcgctaa gacggctcct ggaaagaaga gaccggtaga gccatcaccc cagcgttctc     2580

cagactcctc tacgggcatc ggcaagaaag gccaacagcc cgccagaaaa agactcaatt     2640

ttggtcagac tggcgactca gagtcagttc cagaccctca acctctcgga gaacctccag     2700

cagcgccctc tggtgtggga cctaatacaa tggctgcagg cggtggcgca ccaatggcag     2760

acaataacga aggcgccgac ggagtgggta gttcctcggg aaattggcat tgcgattcca     2820

catggctggg cgacagagtc atcaccacca gcacccgaac ctgggccctg cccacctaca     2880

acaaccacct ctacaagcaa atctccaacg ggacatcggg aggagccacc aacgacaaca     2940

cctacttcgg ctacagcacc ccctgggggt attttgactt taacagattc cactgccact     3000

tttcaccacg tgactggcag cgactcatca acaacaactg gggattccgg cccaagagac     3060

tcagcttcaa gctcttcaac atccaggtca aggaggtcac gcagaatgaa ggcaccaaga     3120

ccatcgccaa taacctcacc agcaccatcc aggtgtttac ggactcggag taccagctgc     3180

cgtacgttct cggctctgcc caccagggct gcctgcctcc gttcccggcg gacgtgttca     3240

tgattcccca gtacggctac ctaacactca acaacggtag tcaggccgtg ggacgctcct     3300

ccttctactg cctggaatac tttccttcgc agatgctgag aaccggcaac aacttccagt     3360

ttacttacac cttcgaggac gtgcctttcc acagcagcta cgcccacagc cagagcttgg     3420

accggctgat gaatcctctg attgaccagt acctgtacta cttgtctcgg actcaaacaa     3480

caggaggcac ggcaaatacg cagactctgg gcttcagcca aggtgggcct aatacaatgg     3540

ccaatcaggc aaagaactgg ctgccaggac cctgttaccg ccaacaacgc gtctcaacga     3600

caaccgggca aaacaacaat agcaactttg cctggactgc tgggaccaaa taccatctga     3660

atggaagaaa ttcattggct aatcctggca tcgctatggc aacacacaaa gacgacgagg     3720

agcgtttttt tcccagtaac gggatcctga tttttggcaa acaaaatgct gccagagaca     3780

atgcggatta cagcgatgtc atgctcacca gcgaggaaga aatcaaaacc actaaccctg     3840

tggctacaga ggaatacggt atcgtggcag ataacttgca gcagcaaaac acggctcctc     3900

aaattggaac tgtcaacagc cagggggcct tacccggtat ggtctggcag aaccgggacg     3960

tgtacctgca gggtcccatc tgggccaaga ttcctcacac ggacggcaac ttccacccgt     4020

ctccgctgat gggcggcttt ggcctgaaac atcctccgcc tcagatcctg atcaagaaca     4080

cgcctgtacc tgcggatcct ccgaccacct tcaaccagtc aaagctgaac tctttcatca     4140

cgcaatacag caccggacag gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca     4200

gcaagcgctg gaaccccgag atccagtaca cctccaacta ctacaaatct acaagtgtgg     4260

actttgctgt taatacagaa ggcgtgtact ctgaaccccg ccccattggc acccgttacc     4320

tcacccgtaa tctgtaattg cctgttaatc aataaaccgg ttgattcgtt tcagttgaac     4380

tttggtctct gcg                                                        4393


<210>  3
<211>  6354
<212>  DNA
<213>  Plasmid with luciferase and mouse periostin promoter

<400>  3
gaactcgatc gagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg       60

gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt      120

ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc      180

tacgtagcca tgctctagag acctctgtag gctggctggt gatactcaat tttatttcat      240

gtatacacaa cattttaaag atggaaatta gtacatgatt cttgatttaa attctttcaa      300

gctaacaatc tttttttttt ttttaaagtg gcctcagtca aagacactaa agatcaccga      360

gtcttgcata gagtttccat ttacaggact agagaaagct agtggagaca cagatcgggt      420

gcggaggtag tgagaagcac ttttcctaag aaggtgcagg gttgactcca aggcttggct      480

gggttataag agttacatgt attatttatt ctatatgtaa gcaacttttg agctcatgtg      540

ccatggcaac ctatggaccg catgttaata tagaagcatt ttaaaattag tgatacaatc      600

aagaccaagg gcatcctgct tatggtttgt gtgcacaggc ttacagagtg cagagtccgc      660

gaggagtccc agggactgct ggagtttgag gttggtttca cagtggtgag taagcgtggc      720

agtgtaatga cctcatggtc tcccgaggcc agataacaga gaactgccta taaatcagca      780

tgccgcggct agagagaaac ggccctgttt ctcagacaca ctatctctct tcagctacat      840

aatgaaccat ttctttctca gtaatgactt acatctctgg gtcagacttt gcagccctgg      900

aaagtcggac ttcattttca tgatttccgt catcttcccg actggtagga aaattgcagg      960

ggtcagtagt gtcagcatag tttcacagag ctgaagagaa agggccctgt gtggagagcg     1020

acttttgatg agagccccgg aagagagtgt gcccttccgg ggattttttt cccagtctct     1080

tctacaactt cagctagcca attgaggggc atgtgtctct tccacataag ctgtggaaat     1140

cacactttaa atgcattgta catctatcca ggatttgggt taaatgcccc tgtgatttct     1200

cttctccgtg ttctgctgtg gagtgattta agtgcaatca gatcaaacca ggaaagtaac     1260

tgagctcaga gacacagagt gtggtggcag agacagaagg cagagagatc cctaaactca     1320

gaatcagctc ttttcgcaat gtaaacctat agaagtgaaa aacgggctca ccatgattga     1380

aaacaaatag gagacagagt tcagattgct cagaacccag gagatttcca gggacagccc     1440

agggctgctg gtgcttctgt aaggccatcg caagcttcag gttggcccag cgccccctcc     1500

cacagccttg ctccctccca cagcccagag ctatataaac tcagctctcc agagcacagg     1560

ccagatctct tcctggacgg agctcagggc tgaaggaatt ggatggggac cgaaccatgg     1620

aagacgccaa aaacataaag aaaggcccgg cgccattcta tccgctggaa gatggaaccg     1680

ctggagagca actgcataag gctatgaaga gatacgccct ggttcctgga acaattgctt     1740

ttacagatgc acatatcgag gtggacatca cttacgctga gtacttcgaa atgtccgttc     1800

ggttggcaga agctatgaaa cgatatgggc tgaatacaaa tcacagaatc gtcgtatgca     1860

gtgaaaactc tcttcaattc tttatgccgg tgttgggcgc gttatttatc ggagttgcag     1920

ttgcgcccgc gaacgacatt tataatgaac gtgaattgct caacagtatg ggcatttcgc     1980

agcctaccgt ggtgttcgtt tccaaaaagg ggttgcaaaa aattttgaac gtgcaaaaaa     2040

agctcccaat catccaaaaa attattatca tggattctaa aacggattac cagggatttc     2100

agtcgatgta cacgttcgtc acatctcatc tacctcccgg ttttaatgaa tacgattttg     2160

tgccagagtc cttcgatagg gacaagacaa ttgcactgat catgaactcc tctggatcta     2220

ctggtctgcc taaaggtgtc gctctgcctc atagaactgc ctgcgtgaga ttctcgcatg     2280

ccagagatcc tatttttggc aatcaaatca ttccggatac tgcgatttta agtgttgttc     2340

cattccatca cggttttgga atgtttacta cactcggata tttgatatgt ggatttcgag     2400

tcgtcttaat gtatagattt gaagaagagc tgtttctgag gagccttcag gattacaaga     2460

ttcaaagtgc gctgctggtg ccaaccctat tctccttctt cgccaaaagc actctgattg     2520

acaaatacga tttatctaat ttacacgaaa ttgcttctgg tggcgctccc ctctctaagg     2580

aagtcgggga agcggttgcc aagaggttcc atctgccagg tatcaggcaa ggatatgggc     2640

tcactgagac tacatcagct attctgatta cacccgaggg ggatgataaa ccgggcgcgg     2700

tcggtaaagt tgttccattt tttgaagcga aggttgtgga tctggatacc gggaaaacgc     2760

tgggcgttaa tcaaagaggc gaactgtgtg tgagaggtcc tatgattatg tccggttatg     2820

taaacaatcc ggaagcgacc aacgccttga ttgacaagga tggatggcta cattctggag     2880

acatagctta ctgggacgaa gacgaacact tcttcatcgt tgaccgcctg aagtctctga     2940

ttaagtacaa aggctatcag gtggctcccg ctgaattgga atccatcttg ctccaacacc     3000

ccaacatctt cgacgcaggt gtcgcaggtc ttcccgacga tgacgccggt gaacttcccg     3060

ccgccgttgt tgttttggag cacggaaaga cgatgacgga aaaagagatc gtggattacg     3120

tcgccagtca agtaacaacc gcgaaaaagt tgcgcggagg agttgtgttt gtggacgaag     3180

taccgaaagg tcttaccgga aaactcgacg caagaaaaat cagagagatc ctcataaagg     3240

ccaagaaggg cggaaagatc gccgtgtaat tctagcggcc gctcgaggcc ggcaaggccg     3300

gatccacaaa caccattgtc acactccagt atacacaaac accattgtca cactccagat     3360

atcacaaaca ccattgtcac actccagaat tcggatccag acatgataag atacattgat     3420

gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt     3480

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat     3540

tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta aagcaagtaa     3600

aacctctaca aatgtggtat ggctgattat gatccggctg cctcgcgcgt ttcggtgatg     3660

acggtgaaaa cctctgacac atgcagctcc cggagacggt cacagcttgt ctgtaagcgg     3720

atgccgggag cagacaagcc cgtcagggcg cgtcagcggg tgttggcggg tgtcggggcg     3780

cagccatgag gtcgaccgta gataagtagc atggcgggtt aatcattaac tacaaggaac     3840

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3900

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3960

gccagctgaa gctatcagat ctgccggtct ccctatagtg agtcgtatta atttcgataa     4020

gccaggttaa cctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     4080

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag     4140

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     4200

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     4260

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     4320

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     4380

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     4440

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     4500

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     4560

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     4620

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     4680

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     4740

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     4800

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     4860

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     4920

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     4980

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     5040

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     5100

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     5160

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     5220

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     5280

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     5340

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     5400

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     5460

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     5520

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     5580

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     5640

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     5700

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     5760

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     5820

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     5880

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     5940

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     6000

cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta acctataaaa     6060

ataggcgtat cacgaggccc tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct     6120

gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac     6180

aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg     6240

catcagagca gattgtactg agagtgcacc atatggacat attgtcgtta gaacgcggct     6300

acaattaata cataacctta tgtatcatac acatacgatt taggtgacac tata           6354


<210>  4
<211>  5353
<212>  DNA
<213>  plasmid wth GFP and mouse periostion promoter

<400>  4
gaactcgatc gagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg       60

gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt      120

ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc      180

tacgtagcca tgctctagag acctctgtag gctggctggt gatactcaat tttatttcat      240

gtatacacaa cattttaaag atggaaatta gtacatgatt cttgatttaa attctttcaa      300

gctaacaatc tttttttttt ttttaaagtg gcctcagtca aagacactaa agatcaccga      360

gtcttgcata gagtttccat ttacaggact agagaaagct agtggagaca cagatcgggt      420

gcggaggtag tgagaagcac ttttcctaag aaggtgcagg gttgactcca aggcttggct      480

gggttataag agttacatgt attatttatt ctatatgtaa gcaacttttg agctcatgtg      540

ccatggcaac ctatggaccg catgttaata tagaagcatt ttaaaattag tgatacaatc      600

aagaccaagg gcatcctgct tatggtttgt gtgcacaggc ttacagagtg cagagtccgc      660

gaggagtccc agggactgct ggagtttgag gttggtttca cagtggtgag taagcgtggc      720

agtgtaatga cctcatggtc tcccgaggcc agataacaga gaactgccta taaatcagca      780

tgccgcggct agagagaaac ggccctgttt ctcagacaca ctatctctct tcagctacat      840

aatgaaccat ttctttctca gtaatgactt acatctctgg gtcagacttt gcagccctgg      900

aaagtcggac ttcattttca tgatttccgt catcttcccg actggtagga aaattgcagg      960

ggtcagtagt gtcagcatag tttcacagag ctgaagagaa agggccctgt gtggagagcg     1020

acttttgatg agagccccgg aagagagtgt gcccttccgg ggattttttt cccagtctct     1080

tctacaactt cagctagcca attgaggggc atgtgtctct tccacataag ctgtggaaat     1140

cacactttaa atgcattgta catctatcca ggatttgggt taaatgcccc tgtgatttct     1200

cttctccgtg ttctgctgtg gagtgattta agtgcaatca gatcaaacca ggaaagtaac     1260

tgagctcaga gacacagagt gtggtggcag agacagaagg cagagagatc cctaaactca     1320

gaatcagctc ttttcgcaat gtaaacctat agaagtgaaa aacgggctca ccatgattga     1380

aaacaaatag gagacagagt tcagattgct cagaacccag gagatttcca gggacagccc     1440

agggctgctg gtgcttctgt aaggccatcg caagcttcag gttggcccag cgccccctcc     1500

cacagccttg ctccctccca cagcccagag ctatataaac tcagctctcc agagcacagg     1560

ccagatctct tcctggacgg agctcagggc tgaaggaatt ctgcagtcga cggtaccgcg     1620

ggcccgggat ccaccggtcg ccaccatggt gagcaagggc gaggagctgt tcaccggggt     1680

ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc cacaagttca gcgtgtccgg     1740

cgagggcgag ggcgatgcca cctacggcaa gctgaccctg aagttcatct gcaccaccgg     1800

caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctacggcg tgcagtgctt     1860

cagccgctac cccgaccaca tgaagcagca cgacttcttc aagtccgcca tgcccgaagg     1920

ctacgtccag gagcgcacca tcttcttcaa ggacgacggc aactacaaga cccgcgccga     1980

ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa     2040

ggaggacggc aacatcctgg ggcacaagct ggagtacaac tacaacagcc acaacgtcta     2100

tatcatggcc gacaagcaga agaacggcat caaggtgaac ttcaagatcc gccacaacat     2160

cgaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca tcggcgacgg     2220

ccccgtgctg ctgcccgaca accactacct gagcacccag tccgccctga gcaaagaccc     2280

caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg ggatcactct     2340

cggcatggac gagctgtaca agtaaagcgg ccgctcgagg ccggcaaggc cggatccaga     2400

catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg     2460

ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa     2520

acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga     2580

ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg atccggctgc     2640

ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc     2700

acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt     2760

gttggcgggt gtcggggcgc agccatgagg tcgaccgtag ataagtagca tggcgggtta     2820

atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     2880

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     2940

tcagtgagcg agcgagcgcg ccagctgaag ctatcagatc tgccggtctc cctatagtga     3000

gtcgtattaa tttcgataag ccaggttaac ctgcattaat gaatcggcca acgcgcgggg     3060

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     3120

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     3180

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     3240

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     3300

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     3360

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     3420

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     3480

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     3540

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     3600

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     3660

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     3720

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     3780

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     3840

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     3900

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     3960

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     4020

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     4080

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     4140

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     4200

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     4260

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     4320

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     4380

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     4440

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     4500

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     4560

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     4620

agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa     4680

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     4740

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     4800

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     4860

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     4920

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4980

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc     5040

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtctcgc gcgtttcggt     5100

gatgacggtg aaaacctctg acacatgcag ctcccggaga cggtcacagc ttgtctgtaa     5160

gcggatgccg ggagcagaca agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg     5220

ggctggctta actatgcggc atcagagcag attgtactga gagtgcacca tatggacata     5280

ttgtcgttag aacgcggcta caattaatac ataaccttat gtatcataca catacgattt     5340

aggtgacact ata                                                        5353


<210>  5
<211>  5740
<212>  DNA
<213>  plasmid with cre, mouse periostin promoter, and mammalian miR122

<400>  5
gaactcgatc gagcagctgc gcgctcgctc gctcactgag gccgcccggg caaagcccgg       60

gcgtcgggcg acctttggtc gcccggcctc agtgagcgag cgagcgcgca gagagggagt      120

ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc      180

tacgtagcca tgctctagag acctctgtag gctggctggt gatactcaat tttatttcat      240

gtatacacaa cattttaaag atggaaatta gtacatgatt cttgatttaa attctttcaa      300

gctaacaatc tttttttttt ttttaaagtg gcctcagtca aagacactaa agatcaccga      360

gtcttgcata gagtttccat ttacaggact agagaaagct agtggagaca cagatcgggt      420

gcggaggtag tgagaagcac ttttcctaag aaggtgcagg gttgactcca aggcttggct      480

gggttataag agttacatgt attatttatt ctatatgtaa gcaacttttg agctcatgtg      540

ccatggcaac ctatggaccg catgttaata tagaagcatt ttaaaattag tgatacaatc      600

aagaccaagg gcatcctgct tatggtttgt gtgcacaggc ttacagagtg cagagtccgc      660

gaggagtccc agggactgct ggagtttgag gttggtttca cagtggtgag taagcgtggc      720

agtgtaatga cctcatggtc tcccgaggcc agataacaga gaactgccta taaatcagca      780

tgccgcggct agagagaaac ggccctgttt ctcagacaca ctatctctct tcagctacat      840

aatgaaccat ttctttctca gtaatgactt acatctctgg gtcagacttt gcagccctgg      900

aaagtcggac ttcattttca tgatttccgt catcttcccg actggtagga aaattgcagg      960

ggtcagtagt gtcagcatag tttcacagag ctgaagagaa agggccctgt gtggagagcg     1020

acttttgatg agagccccgg aagagagtgt gcccttccgg ggattttttt cccagtctct     1080

tctacaactt cagctagcca attgaggggc atgtgtctct tccacataag ctgtggaaat     1140

cacactttaa atgcattgta catctatcca ggatttgggt taaatgcccc tgtgatttct     1200

cttctccgtg ttctgctgtg gagtgattta agtgcaatca gatcaaacca ggaaagtaac     1260

tgagctcaga gacacagagt gtggtggcag agacagaagg cagagagatc cctaaactca     1320

gaatcagctc ttttcgcaat gtaaacctat agaagtgaaa aacgggctca ccatgattga     1380

aaacaaatag gagacagagt tcagattgct cagaacccag gagatttcca gggacagccc     1440

agggctgctg gtgcttctgt aaggccatcg caagcttcag gttggcccag cgccccctcc     1500

cacagccttg ctccctccca cagcccagag ctatataaac tcagctctcc agagcacagg     1560

ccagatctct tcctggacgg agctcagggc tgaaggaatt cgatggggac cgaaaagctt     1620

gtccaccatg gtgcccaaga agaagaggaa agtctccaac ctgctgactg tgcaccaaaa     1680

cctgcctgcc ctccctgtgg atgccacctc tgatgaagtc aggaagaacc tgatggacat     1740

gttcagggac aggcaggcct tctctgaaca cacctggaag atgctcctgt ctgtgtgcag     1800

atcctgggct gcctggtgca agctgaacaa caggaaatgg ttccctgctg aacctgagga     1860

tgtgagggac tacctcctgt acctgcaagc cagaggcctg gctgtgaaga ccatccaaca     1920

gcacctgggc cagctcaaca tgctgcacag gagatctggc ctgcctcgcc cttctgactc     1980

caatgctgtg tccctggtga tgaggagaat cagaaaggag aatgtggatg ctggggagag     2040

agccaagcag gccctggcct ttgaacgcac tgactttgac caagtcagat ccctgatgga     2100

gaactctgac agatgccagg acatcaggaa cctggccttc ctgggcattg cctacaacac     2160

cctgctgcgc attgccgaaa ttgccagaat cagagtgaag gacatctccc gcaccgatgg     2220

tgggagaatg ctgatccaca ttggcaggac caagaccctg gtgtccacag ctggtgtgga     2280

gaaggccctg tccctggggg ttaccaagct ggtggagaga tggatctctg tgtctggtgt     2340

ggctgatgac cccaacaact acctgttctg ccgggtcaga aagaatggtg tggctgcccc     2400

ttctgccacc tcccaactgt ccacccgggc cctggaaggg atctttgagg ccacccaccg     2460

cctgatctat ggtgccaagg atgactctgg gcagagatac ctggcctggt ctggccactc     2520

tgccagagtg ggtgctgcca gggacatggc cagggctggt gtgtccatcc ctgaaatcat     2580

gcaggctggt ggctggacca atgtgaacat tgtgatgaac tacatcagaa acctggactc     2640

tgagactggg gccatggtga ggctgctcga ggatggggac tgaaaggatc cacaaacacc     2700

attgtcacac tccagtatac acaaacacca ttgtcacact ccagatatca caaacaccat     2760

tgtcacactc cagaattcgg atccagacat gataagatac attgatgagt ttggacaaac     2820

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     2880

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     2940

gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     3000

tggtatggct gattatgatc cggctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc     3060

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     3120

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgaggtcg     3180

accgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     3240

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     3300

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcca gctgaagcta     3360

tcagatctgc cggtctccct atagtgagtc gtattaattt cgataagcca ggttaacctg     3420

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     3480

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     3540

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     3600

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     3660

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     3720

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     3780

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     3840

ctttctcata gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     3900

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     3960

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     4020

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     4080

ggctacacta gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     4140

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     4200

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     4260

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     4320

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     4380

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     4440

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     4500

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     4560

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     4620

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     4680

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     4740

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     4800

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     4860

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     4920

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     4980

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     5040

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     5100

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     5160

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     5220

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     5280

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     5340

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaagtgcca     5400

cctgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag gcgtatcacg     5460

aggccctttc gtctcgcgcg tttcggtgat gacggtgaaa acctctgaca catgcagctc     5520

ccggagacgg tcacagcttg tctgtaagcg gatgccggga gcagacaagc ccgtcagggc     5580

gcgtcagcgg gtgttggcgg gtgtcggggc tggcttaact atgcggcatc agagcagatt     5640

gtactgagag tgcaccatat ggacatattg tcgttagaac gcggctacaa ttaatacata     5700

accttatgta tcatacacat acgatttagg tgacactata                           5740


<210>  6
<211>  1395
<212>  DNA
<213>  Mus musculus

<400>  6
gacctctgta ggctggctgg tgatactcaa ttttatttca tgtatacaca acattttaaa       60

gatggaaatt agtacatgat tcttgattta aattctttca agctaacaat cttttttttt      120

tttttaaagt ggcctcagtc aaagacacta aagatcaccg agtcttgcat agagtttcca      180

tttacaggac tagagaaagc tagtggagac acagatcggg tgcggaggta gtgagaagca      240

cttttcctaa gaaggtgcag ggttgactcc aaggcttggc tgggttataa gagttacatg      300

tattatttat tctatatgta agcaactttt gagctcatgt gccatggcaa cctatggacc      360

gcatgttaat atagaagcat tttaaaatta gtgatacaat caagaccaag ggcatcctgc      420

ttatggtttg tgtgcacagg cttacagagt gcagagtccg cgaggagtcc cagggactgc      480

tggagtttga ggttggtttc acagtggtga gtaagcgtgg cagtgtaatg acctcatggt      540

ctcccgaggc cagataacag agaactgcct ataaatcagc atgccgcggc tagagagaaa      600

cggccctgtt tctcagacac actatctctc ttcagctaca taatgaacca tttctttctc      660

agtaatgact tacatctctg ggtcagactt tgcagccctg gaaagtcgga cttcattttc      720

atgatttccg tcatcttccc gactggtagg aaaattgcag gggtcagtag tgtcagcata      780

gtttcacaga gctgaagaga aagggccctg tgtggagagc gacttttgat gagagccccg      840

gaagagagtg tgcccttccg gggatttttt tcccagtctc ttctacaact tcagctagcc      900

aattgagggg catgtgtctc ttccacataa gctgtggaaa tcacacttta aatgcattgt      960

acatctatcc aggatttggg ttaaatgccc ctgtgatttc tcttctccgt gttctgctgt     1020

ggagtgattt aagtgcaatc agatcaaacc aggaaagtaa ctgagctcag agacacagag     1080

tgtggtggca gagacagaag gcagagagat ccctaaactc agaatcagct cttttcgcaa     1140

tgtaaaccta tagaagtgaa aaacgggctc accatgattg aaaacaaata ggagacagag     1200

ttcagattgc tcagaaccca ggagatttcc agggacagcc cagggctgct ggtgcttctg     1260

taaggccatc gcaagcttca ggttggccca gcgccccctc ccacagcctt gctccctccc     1320

acagcccaga gctatataaa ctcagctctc cagagcacag gccagatctc ttcctggacg     1380

gagctcaggg ctgaa                                                      1395


<210>  7
<211>  4683
<212>  DNA
<213>  adeno-associated virus 6

<400>  7
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctggagg ggtggagtcg tgacgtgaat tacgtcatag      180

ggttagggag gtcctgtatt agaggtcacg tgagtgtttt gcgacatttt gcgacaccat      240

gtggtcacgc tgggtattta agcccgagtg agcacgcagg gtctccattt tgaagcggga      300

ggtttgaacg cgcagcgcca tgccggggtt ttacgagatt gtgattaagg tccccagcga      360

ccttgacgag catctgcccg gcatttctga cagctttgtg aactgggtgg ccgagaagga      420

atgggagttg ccgccagatt ctgacatgga tctgaatctg attgagcagg cacccctgac      480

cgtggccgag aagctgcagc gcgacttcct ggtccagtgg cgccgcgtga gtaaggcccc      540

ggaggccctc ttctttgttc agttcgagaa gggcgagtcc tacttccacc tccatattct      600

ggtggagacc acgggggtca aatccatggt gctgggccgc ttcctgagtc agattaggga      660

caagctggtg cagaccatct accgcgggat cgagccgacc ctgcccaact ggttcgcggt      720

gaccaagacg cgtaatggcg ccggaggggg gaacaaggtg gtggacgagt gctacatccc      780

caactacctc ctgcccaaga ctcagcccga gctgcagtgg gcgtggacta acatggagga      840

gtatataagc gcgtgtttaa acctggccga gcgcaaacgg ctcgtggcgc acgacctgac      900

ccacgtcagc cagacccagg agcagaacaa ggagaatctg aaccccaatt ctgacgcgcc      960

tgtcatccgg tcaaaaacct ccgcacgcta catggagctg gtcgggtggc tggtggaccg     1020

gggcatcacc tccgagaagc agtggatcca ggaggaccag gcctcgtaca tctccttcaa     1080

cgccgcctcc aactcgcggt cccagatcaa ggccgctctg gacaatgccg gcaagatcat     1140

ggcgctgacc aaatccgcgc ccgactacct ggtaggcccc gctccgcccg ccgacattaa     1200

aaccaaccgc atttaccgca tcctggagct gaacggctac gaccctgcct acgccggctc     1260

cgtctttctc ggctgggccc agaaaaggtt cggaaaacgc aacaccatct ggctgtttgg     1320

gccggccacc acgggcaaga ccaacatcgc ggaagccatc gcccacgccg tgcccttcta     1380

cggctgcgtc aactggacca atgagaactt tcccttcaac gattgcgtcg acaagatggt     1440

gatctggtgg gaggagggca agatgacggc caaggtcgtg gagtccgcca aggccattct     1500

cggcggcagc aaggtgcgcg tggaccaaaa gtgcaagtcg tccgcccaga tcgatcccac     1560

ccccgtgatc gtcacctcca acaccaacat gtgcgccgtg attgacggga acagcaccac     1620

cttcgagcac cagcagccgt tgcaggaccg gatgttcaaa tttgaactca cccgccgtct     1680

ggagcatgac tttggcaagg tgacaaagca ggaagtcaaa gagttcttcc gctgggcgca     1740

ggatcacgtg accgaggtgg cgcatgagtt ctacgtcaga aagggtggag ccaacaagag     1800

acccgccccc gatgacgcgg ataaaagcga gcccaagcgg gcctgcccct cagtcgcgga     1860

tccatcgacg tcagacgcgg aaggagctcc ggtggacttt gccgacaggt accaaaacaa     1920

atgttctcgt cacgcgggca tgcttcagat gctgtttccc tgcaaaacat gcgagagaat     1980

gaatcagaat ttcaacattt gcttcacgca cgggaccaga gactgttcag aatgtttccc     2040

cggcgtgtca gaatctcaac cggtcgtcag aaagaggacg tatcggaaac tctgtgccat     2100

tcatcatctg ctggggcggg ctcccgagat tgcttgctcg gcctgcgatc tggtcaacgt     2160

ggatctggat gactgtgttt ctgagcaata aatgacttaa accaggtatg gctgccgatg     2220

gttatcttcc agattggctc gaggacaacc tctctgaggg cattcgcgag tggtgggact     2280

tgaaacctgg agccccgaaa cccaaagcca accagcaaaa gcaggacgac ggccggggtc     2340

tggtgcttcc tggctacaag tacctcggac ccttcaacgg actcgacaag ggggagcccg     2400

tcaacgcggc ggatgcagcg gccctcgagc acgacaaggc ctacgaccag cagctcaaag     2460

cgggtgacaa tccgtacctg cggtataacc acgccgacgc cgagtttcag gagcgtctgc     2520

aagaagatac gtcttttggg ggcaacctcg ggcgagcagt cttccaggcc aagaagaggg     2580

ttctcgaacc ttttggtctg gttgaggaag gtgctaagac ggctcctgga aagaaacgtc     2640

cggtagagca gtcgccacaa gagccagact cctcctcggg cattggcaag acaggccagc     2700

agcccgctaa aaagagactc aattttggtc agactggcga ctcagagtca gtccccgacc     2760

cacaacctct cggagaacct ccagcaaccc ccgctgctgt gggacctact acaatggctt     2820

caggcggtgg cgcaccaatg gcagacaata acgaaggcgc cgacggagtg ggtaatgcct     2880

caggaaattg gcattgcgat tccacatggc tgggcgacag agtcatcacc accagcaccc     2940

gaacatgggc cttgcccacc tataacaacc acctctacaa gcaaatctcc agtgcttcaa     3000

cgggggccag caacgacaac cactacttcg gctacagcac cccctggggg tattttgatt     3060

tcaacagatt ccactgccat ttctcaccac gtgactggca gcgactcatc aacaacaatt     3120

ggggattccg gcccaagaga ctcaacttca agctcttcaa catccaagtc aaggaggtca     3180

cgacgaatga tggcgtcacg accatcgcta ataaccttac cagcacggtt caagtcttct     3240

cggactcgga gtaccagttg ccgtacgtcc tcggctctgc gcaccagggc tgcctccctc     3300

cgttcccggc ggacgtgttc atgattccgc agtacggcta cctaacgctc aacaatggca     3360

gccaggcagt gggacggtca tccttttact gcctggaata tttcccatcg cagatgctga     3420

gaacgggcaa taactttacc ttcagctaca ccttcgagga cgtgcctttc cacagcagct     3480

acgcgcacag ccagagcctg gaccggctga tgaatcctct catcgaccag tacctgtatt     3540

acctgaacag aactcagaat cagtccggaa gtgcccaaaa caaggacttg ctgtttagcc     3600

gggggtctcc agctggcatg tctgttcagc ccaaaaactg gctacctgga ccctgttacc     3660

ggcagcagcg cgtttctaaa acaaaaacag acaacaacaa cagcaacttt acctggactg     3720

gtgcttcaaa atataacctt aatgggcgtg aatctataat caaccctggc actgctatgg     3780

cctcacacaa agacgacaaa gacaagttct ttcccatgag cggtgtcatg atttttggaa     3840

aggagagcgc cggagcttca aacactgcat tggacaatgt catgatcaca gacgaagagg     3900

aaatcaaagc cactaacccc gtggccaccg aaagatttgg gactgtggca gtcaatctcc     3960

agagcagcag cacagaccct gcgaccggag atgtgcatgt tatgggagcc ttacctggaa     4020

tggtgtggca agacagagac gtatacctgc agggtcctat ttgggccaaa attcctcaca     4080

cggatggaca ctttcacccg tctcctctca tgggcggctt tggacttaag cacccgcctc     4140

ctcagatcct catcaaaaac acgcctgttc ctgcgaatcc tccggcagag ttttcggcta     4200

caaagtttgc ttcattcatc acccagtatt ccacaggaca agtgagcgtg gagattgaat     4260

gggagctgca gaaagaaaac agcaaacgct ggaatcccga agtgcagtat acatctaact     4320

atgcaaaatc tgccaacgtt gatttcactg tggacaacaa tggactttat actgagcctc     4380

gccccattgg cacccgttac ctcacccgtc ccctgtaatt gtgtgttaat caataaaccg     4440

gttaattcgt gtcagttgaa ctttggtctc atgtcgttat tatcttatct ggtcaccata     4500

gcaaccggtt acacattaac tgcttagttg cgcttcgcga atacccctag tgatggagtt     4560

gcccactccc tctatgcgcg ctcgctcgct cggtggggcc ggcagagcag agctctgccg     4620

tctgcggacc tttggtccgc aggccccacc gagcgagcga gcgcgcatag agggagtggg     4680

caa                                                                   4683


<210>  8
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  8
tccgtgttct gctgtggagt gatt                                              24


<210>  9
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  9
tagggatctc tctgccttct gtct                                              24


