                         SEQUENCE LISTING

<110>  WEINER, David
       MUTHUMANI, Karupiah
       Flingai, Seleeke
       SARDESAI, Niranjan
       Elliott, Sarah
       Yan, Jian
       Patel, Ami
 
<120>  DNA ANTIBODY CONSTRUCTS AND METHOD OF USING SAME

<130>  206108-0033-30-WO.606194

<150>  US 62/311,316
<151>  2016-03-21

<150>  US 62/396,750
<151>  2016-09-19

<150>  US 62/417,093
<151>  2016-11-03

<150>  US 62/417,093
<151>  2016-11-03

<150>  US 62/332,381
<151>  2016-05-04

<150>  US 62/376,162
<151>  2016-08-17

<150>  US 62/429,454
<151>  2016-12-02

<150>  US 62/429,473
<151>  2016-12-02

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of HIV-1 Env-4E10 Ig

<400>  1

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg 
            20                  25                  30          


Pro Gly Ser Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Ser Phe 
        35                  40                  45              


Ser Thr Tyr Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Val Ile Pro Leu Leu Thr Ile Thr Asn Tyr Ala 
65                  70                  75                  80  


Pro Arg Phe Gln Gly Arg Ile Thr Ile Thr Ala Asp Arg Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Leu Glu Leu Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Gly Thr Thr Gly Trp Gly Trp Leu Gly Lys 
        115                 120                 125             


Pro Ile Gly Ala Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys 
465                 470                 475                 480 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
            500                 505                 510         


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Glu Ile Val 
        515                 520                 525             


Leu Thr Gln Ser Pro Gly Thr Gln Ser Leu Ser Pro Gly Glu Arg Ala 
    530                 535                 540                 


Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Asn Asn Lys Leu Ala 
545                 550                 555                 560 


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly 
                565                 570                 575     


Ala Ser Ser Arg Pro Ser Gly Val Ala Asp Arg Phe Ser Gly Ser Gly 
            580                 585                 590         


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp 
        595                 600                 605             


Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gln Ser Leu Ser Thr Phe 
    610                 615                 620                 


Gly Gln Gly Thr Lys Val Glu Lys Arg Thr Val Ala Ala Pro Ser Val 
625                 630                 635                 640 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                645                 650                 655     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            660                 665                 670         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        675                 680                 685             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    690                 695                 700                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
705                 710                 715                 720 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                725                 730                 735     


Gly Glu 
        


<210>  2
<211>  768
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of HIV-1 Env-PG9 Ig

<400>  2

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Phe Leu 
            20                  25                  30          


Arg Gly Val Gln Cys Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val 
        35                  40                  45              


Gln Pro Gly Ser Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp 
    50                  55                  60                  


Phe Ser Arg Gln Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly 
65                  70                  75                  80  


Leu Glu Trp Val Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His 
                85                  90                  95      


Ala Asp Ser Val Trp Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys 
            100                 105                 110         


Asp Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala 
        115                 120                 125             


Thr Tyr Phe Cys Val Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly 
    130                 135                 140                 


Tyr Asn Tyr Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met 
145                 150                 155                 160 


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
                165                 170                 175     


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
            180                 185                 190         


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
        195                 200                 205             


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
    210                 215                 220                 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
225                 230                 235                 240 


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
                245                 250                 255     


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
            260                 265                 270         


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser 
            500                 505                 510         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        515                 520                 525             


Asn Pro Gly Pro Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr 
    530                 535                 540                 


Cys Cys Pro Gly Gly Ser Asn Ser Gln Ser Ala Leu Thr Gln Pro Ala 
545                 550                 555                 560 


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Asn Gly 
                565                 570                 575     


Thr Ser Asn Asp Val Gly Gly Tyr Glu Ser Val Ser Trp Tyr Gln Gln 
            580                 585                 590         


His Pro Gly Lys Ala Pro Lys Val Val Ile Tyr Asp Val Ser Lys Arg 
        595                 600                 605             


Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
    610                 615                 620                 


Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Gly Asp Tyr 
625                 630                 635                 640 


Tyr Cys Lys Ser Leu Thr Ser Thr Arg Arg Arg Val Phe Gly Thr Gly 
                645                 650                 655     


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
            660                 665                 670         


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
        675                 680                 685             


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
    690                 695                 700                 


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
705                 710                 715                 720 


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
                725                 730                 735     


Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr 
            740                 745                 750         


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
        755                 760                 765             


<210>  3
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the Heavy Chain (VH-CH1) of HIV-1 
       Env Fab

<400>  3
aagcttgccg ccaccatgga gactgataca ctgctgctgt gggtgctgct gctgtgggtg       60

ccagggtcaa ccggagatgg ggctcaggtc cagctggtcc agagcggcgg acagatgaag      120

aaacccggcg agagcatgag gatctcctgc agagcatctg gatacgagtt catcgactgt      180

accctgaact ggattaggct ggctcctgga aagagaccag agtggatggg gtggctgaaa      240

ccacgagggg gagcagtgaa ttacgcccgg cccctgcagg gacgagtgac catgaccagg      300

gacgtgtaca gcgataccgc cttcctggag ctgcggtccc tgacagtgga cgatactgct      360

gtctacttct gcacacgcgg aaagaactgt gactataatt gggattttga acactggggc      420

cggggaacac ccgtgatcgt cagctccccc agtactaagg gaccttcagt gtttccactg      480

gccccctcta gtaaatccac ctctggaggg acagccgctc tgggatgcct ggtgaaagat      540

tatttccccg aacctgtgac cgtcagttgg aactcagggg ctctgacttc tggcgtgcac      600

acctttcctg cagtcctgca gtcaagcggg ctgtacagtc tgtcctctgt ggtcactgtg      660

cctagttcaa gcctgggcac tcagacctat atttgtaacg tgaatcataa gccatccaat      720

acaaaagtgg acaaaaaagc cgaacccaaa tcctgttacc cttatgatgt gcccgactac      780

gcctgactcg ag                                                          792


<210>  4
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain (VL-CL) of HIV-1 Env Fab

<400>  4
aagcttgccg ccaccatgga aaccgataca ctgctgctgt gggtgctgct gctgtgggtg       60

ccaggaagta ccggggatgg ggctcaggtc cagattgtgc tgactcagtc ccctgggacc      120

ctgtctctga gtccaggcga gacagctatc atttcatgcc gaactagcca gtacggcagc      180

ctggcttggt atcagcagcg accaggacag gcaccacgac tggtcatcta ctcaggcagc      240

acaagggccg ctggcatccc cgacaggttc tccggcagca ggtgggggcc tgattacaac      300

ctgactatct ctaatctgga gagtggggac tttggcgtgt actattgcca gcagtatgag      360

ttcttcggcc agggaactaa ggtgcaggtg gacatcaaaa gaaccgtggc agccccatcc      420

gtcttcattt ttcccccttc tgatgagcag ctgaagtcag gcaccgccag cgtggtctgt      480

ctgctgaaca atttctaccc ccgggaagcc aaggtgcagt ggaaagtgga caacgctctg      540

cagagtggaa attcacagga gagcgtgacc gaacaggact ccaaggattc tacatatagt      600

ctgagcagca ccctgaccct gagtaaagca gattacgaga agcacaaagt gtatgcctgt      660

gaagtcacac atcagggcct gaggagcccc gtgactaaaa gtttcaaccg aggagagtgc      720

tacccttatg atgtgcccga ctacgcctaa ctcgag                                756


<210>  5
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 IgG

<400>  5

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro 
            20                  25                  30          


Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile 
        35                  40                  45              


Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu 
    50                  55                  60                  


Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg 
65                  70                  75                  80  


Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr 
                85                  90                  95      


Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His 
        115                 120                 125             


Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg 
465                 470                 475                 480 


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Met Asp Trp Thr Trp Ile Leu Phe Leu 
            500                 505                 510         


Val Ala Ala Ala Thr Arg Val His Ser Glu Ile Val Leu Thr Gln Ser 
        515                 520                 525             


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys 
    530                 535                 540                 


Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly 
545                 550                 555                 560 


Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly 
                565                 570                 575     


Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu 
            580                 585                 590         


Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln 
        595                 600                 605             


Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  6
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized Nucleic Acid Sequence Encoding IgG Heavy Chain

<400>  6
ggatccgcca ccatggaaac cgacactctg ctgctgtggg tgctgctgct gtgggtgccc       60

ggctcaacag gcgacggcgc tcaggtccag ctggtccagt ctggagctgt gatcaagacc      120

cctggcagct ccgtcaaaat ttcttgcaga gcaagtggct acaacttccg ggactatagc      180

atccactggg tgcggctgat tcctgataag ggatttgagt ggatcggctg gatcaagcca      240

ctgtggggcg ctgtgtccta cgcaaggcag ctgcaggggc gcgtctccat gacacgacag      300

ctgtctcagg acccagacga tcccgattgg ggggtggcct acatggagtt cagtggactg      360

actcccgcag acaccgccga atatttttgc gtgcggagag gctcctgcga ctactgtggg      420

gatttcccat ggcagtattg gtgtcaggga actgtggtcg tggtctctag tgcatcaacc      480

aagggcccca gcgtgtttcc tctggcccca tcaagcaaaa gtacatcagg aggaactgca      540

gctctgggat gtctggtgaa ggattacttc cccgagcctg tgaccgtcag ctggaactcc      600

ggagcactga cctccggagt gcacacattt cccgctgtcc tgcagtcctc tgggctgtac      660

tctctgagtt cagtggtcac agtgcctagc tcctctctgg gcacccagac atatatctgc      720

aacgtcaatc ataagccaag taatactaaa gtggacaaga aagtcgaacc caaatcatgt      780

tacccctatg acgtgcctga ttatgcttga taactcgag                             819


<210>  7
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized Nucleic Acid Sequence Encoding IgG Light Chain

<400>  7
ggatccgcca ccatggagac tgatacactg ctgctgtggg tgctgctgct gtgggtgcct       60

ggctcaaccg gcgacggggc tcaggtccag attgtgctga cccagagccc tggcatcctg      120

tcactgagcc caggagagac cgcaacactg ttctgcaagg cctcccaggg cgggaacgct      180

atgacatggt accagaaacg gagaggacag gtgccccgac tgctgatcta tgacacttca      240

aggcgagcaa gcggagtgcc tgatcgattt gtcggcagcg gctctgggac agacttcttt      300

ctgactatta ataagctgga cagagaggat ttcgctgtgt actattgcca gcagtttgaa      360

ttctttggac tgggcagcga gctggaagtg cacaggaccg tcgccgctcc aagtgtgttc      420

atttttcccc ctagcgatga gcagctgaaa tccgggacag cctctgtggt ctgtctgctg      480

aacaatttct acccccgcga agcaaaggtg cagtggaaag tcgacaacgc cctgcagagt      540

ggcaattcac aggagagcgt gaccgaacag gactccaagg attctacata tagtctgagc      600

tccactctga ccctgtctaa agctgattac gagaagcaca aagtgtatgc atgcgaagtc      660

actcatcagg gcctgtctag tcctgtgacc aagagcttta accgagggga gtgttaccca      720

tatgacgtcc ccgattacgc ctgataactc gag                                   753


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE1 Signal Peptide of VRC-1 IgG

<400>  8

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  9
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Region of VRC01 IgG

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys Gly 
        115                 120                 125     


<210>  10
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy region 1 (CH1) of VRC01 IgG

<400>  10

Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
1               5                   10                  15      


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
            20                  25                  30          


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
        35                  40                  45              


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
    50                  55                  60                  


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
65                  70                  75                  80  


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys 
                85                  90                  95      


Ser Cys 
        


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Region of VRC01 IgG

<400>  11

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy Region 2 (CH2) of VRC01 IgG

<400>  12

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy Region 3 (CH3) of VRC01 IgG

<400>  13

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site of VRC01 IgG

<400>  14

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  15
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG Linker and P2A Peptide of VRC01 IgG

<400>  15

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  16
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Region (VL) of VRC01 IgG

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Light Region (CL, kappa) of VRC01 IgG

<400>  17

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG Heavy Chain Signal Peptide of HIV-1 Env-PG9 Ig

<400>  18

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  19
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Region of HIV-1 Env-PG9 Ig

<400>  19

Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Phe Leu Arg Gly Val 
1               5                   10                  15      


Gln Cys Gln Arg Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly 
            20                  25                  30          


Ser Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg 
        35                  40                  45              


Gln Gly Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Val Ala Phe Ile Lys Tyr Asp Gly Ser Glu Lys Tyr His Ala Asp Ser 
65                  70                  75                  80  


Val Trp Gly Arg Leu Ser Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu 
                85                  90                  95      


Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Thr Tyr Phe 
            100                 105                 110         


Cys Val Arg Glu Ala Gly Gly Pro Asp Tyr Arg Asn Gly Tyr Asn Tyr 
        115                 120                 125             


Tyr Asp Phe Tyr Asp Gly Tyr Tyr Asn Tyr His Tyr Met Asp Val Trp 
    130                 135                 140                 


Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
145                 150                 


<210>  20
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy region 1 (CH1) of HIV-1 Env-PG9 Ig

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Region of HIV-1 Env-PG9 Ig

<400>  21

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  22
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy Region 2 (CH2) of HIV-1 Env-PG9 Ig

<400>  22

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  23
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy Region 3 (CH3) of HIV-1 Env-PG9 Ig

<400>  23

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site of HIV-1 Env-PG9 Ig

<400>  24

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  25
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG Linker and P2A Peptide of HIV-1 Env-PG9 Ig

<400>  25

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lamba Light Chain Signal Peptide of HIV-1 Env-PG9 Ig

<400>  26

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser 
            20  


<210>  27
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Region (VL) of HIV-1 Env-PG9 Ig

<400>  27

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Asn Gly Thr Ser Asn Asp Val Gly Gly Tyr 
            20                  25                  30          


Glu Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Val Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Lys Ser Leu Thr Ser Thr 
                85                  90                  95      


Arg Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  28
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Light Region (CL, lamba) of HIV-1 Env-PG9 Ig

<400>  28

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG Heavy Chain Signal Peptide of HIV-1 Env-4E10 Ig

<400>  29

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  30
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy Region of HIV-1 Env-4E10 Ig

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Thr Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Ser Thr Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Val Ile Pro Leu Leu Thr Ile Thr Asn Tyr Ala Pro Arg Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Thr Gly Trp Gly Trp Leu Gly Lys Pro Ile Gly 
            100                 105                 110         


Ala Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  31
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy region 1 (CH1) of HIV-1 Env-4E10 Ig

<400>  31

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge Region of HIV-1 Env-4E10 Ig

<400>  32

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  33
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy Region 2 (CH2) of HIV-1 Env-4E10 Ig

<400>  33

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Heavy Region 3 (CH3) of HIV-1 Env-4E10 Ig

<400>  34

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin Cleavage Site of HIV-1 Env-4E10 Ig

<400>  35

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  36
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSG Linker and P2A Peptide of HIV-1 Env-4E10 Ig

<400>  36

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Kappa Light Chain Signal Peptide of HIV-1 Env-4E10 Ig

<400>  37

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  38
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Light Region (VL) of HIV-1 Env-4E10 Ig

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Gln Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Asn Asn 
            20                  25                  30          


Lys Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Pro Ser Gly Val Ala Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Gln Ser Leu 
                85                  90                  95      


Ser Thr Phe Gly Gln Gly Thr Lys Val Glu 
            100                 105     


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant Light Region (CL, kappa) of HIV-1 Env-4E10 Ig

<400>  39

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
1               5                   10                  15      


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
            20                  25                  30          


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
        35                  40                  45              


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
    50                  55                  60                  


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
65                  70                  75                  80  


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
                85                  90                  95      


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105         


<210>  40
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the VH-CH1 of anti-Her-2 Fab

<400>  40
ggatccgcca ccatggactg gacatggatt ctgtttctgg tcgccgccgc tacaagagtg       60

cattccgaag tgcagctggt cgagagtgga gggggactgg tgcagcccgg cggatctctg      120

cgactgagtt gcgccgcttc aggcttcacc tttacagact acaccatgga ttgggtgaga      180

caggcacctg gcaagggact ggagtgggtg gctgatgtca acccaaatag tgggggctca      240

atctacaacc agaggttcaa gggcaggttc accctgagcg tggacaggtc caaaaacact      300

ctgtatctgc agatgaattc tctgcgggct gaagataccg cagtctacta ttgcgcccgc      360

aatctgggcc caagcttcta ctttgactat tgggggcagg gcacactggt gactgtcagc      420

tccgcttcta caaagggacc aagcgtgttc ccactggcac cctctagtaa atccacctct      480

ggagggacag cagccctggg ctgtctggtg aaagactatt tccccgagcc tgtgactgtc      540

agctggaact ccggagcact gactagcgga gtgcacacct ttccagccgt cctgcagtca      600

agcggcctgt actccctgtc ctctgtggtc acagtgccta gttcaagcct gggaactcag      660

acctatattt gtaatgtgaa ccataaacca agcaatacaa aggtggacaa gaaggtggaa      720

ccaaaatcct gctgataact cgag                                             744


<210>  41
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the VH-CH1 of anti-Her-2 Fab

<400>  41

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr 
        35                  40                  45              


Asp Tyr Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln 
65                  70                  75                  80  


Arg Phe Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


<210>  42
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the VL-CL of anti-Her-2 Fab

<400>  42
ggatccgcca ccatggattg gacttggatt ctgttcctgg tcgccgccgc tacccgcgtg       60

cattccgata ttcagatgac tcagagcccc tcctcactgt cagccagcgt gggcgaccga      120

gtcaccatca catgcaaagc ttctcaggat gtgagtattg gggtcgcatg gtaccagcag      180

aagccaggca aagcacccaa gctgctgatc tattccgcct cttacaggta tacaggagtg      240

cccagcagat tcagtggctc aggaagcggg actgacttta ctctgaccat cagctccctg      300

cagcctgagg atttcgctac ctactattgc cagcagtact atatctaccc atataccttt      360

ggccagggaa caaaagtgga gatcaagcgg accgtggccg ctccctccgt cttcattttt      420

cccccttctg acgaacagct gaagagcgga acagcaagcg tggtctgtct gctgaacaat      480

ttctaccctc gcgaggccaa agtgcagtgg aaggtcgata acgctctgca gtccgggaat      540

tctcaggaga gtgtgactga acaggactca aaagatagca cctattccct gtctagtaca      600

ctgactctga gcaaggcaga ctacgaaaag cacaaagtgt atgcctgtga ggtcacccac      660

caggggctgt caagtcccgt caccaagtcc ttcaatagag gcgaatgctg ataactcgag      720


<210>  43
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the VL-CL of anti-Her-2 Fab

<400>  43

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser 
        35                  40                  45              


Ile Gly Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr 
            100                 105                 110         


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  44
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding anti-DENV Human IgG

<400>  44
ggatccgcca ccatggactg gacttggagg attctgtttc tggtcgccgc cgctactggg       60

actcacgctc aggcacatct ggtcgaatct ggaggaggag tggtccagcc tggccgatcc      120

ctgcgactgt cttgcgcagc tagcgccttc aacttcagca caaacgcaat gcactgggtg      180

cgacaggcac caggcaaggg actggagtgg gtcgctgtga tctcatacga cggaagccat      240

aagtactatg cagattctgt gaaaggccgg ttcaccattt ccagggacaa ttctaagaac      300

accctgtatc tgcagatgaa tagcctgcgc gcagccgata ccgcagtgta ctattgcgca      360

actgtcggcg tgctgacctg gccagtgaac gccgaatact ttcaccattg gggacagggc      420

agtctggtct cagtgagctc cgcaagtact aagggaccat cagtgttccc actggcaccc      480

tctagtaaat ctactagtgg cgggaccgct gcactgggat gtctggtgaa ggactatttc      540

cccgagcctg tcaccgtgag ctggaattcc ggagccctga caagcggcgt ccacactttt      600

cccgctgtgc tgcagtcaag cggactgtac tccctgtcct ctgtggtcac tgtgcctagt      660

tcaagcctgg gcactcagac ctatatctgc aatgtgaacc acaagccctc taacaccaaa      720

gtcgacaaga aagtggaacc taagagctgt gataaaacac atacttgccc accttgtcca      780

gcaccagagc tgctgggagg accaagcgtg ttcctgtttc cacccaagcc taaagacaca      840

ctgatgatta gccggacacc tgaagtcact tgcgtggtcg tggacgtgtc ccacgaggac      900

cccgaagtca agtttaattg gtacgtggat ggcgtcgagg tgcataacgc caagaccaaa      960

ccccgggagg aacagtacaa tagcacatat agagtcgtgt ccgtcctgac tgtgctgcat     1020

caggattggc tgaatgggaa ggagtataag tgcaaagtgt ctaacaaggc tctgcctgca     1080

ccaatcgaga aaaccattag caaggctaaa ggccagccta gggaaccaca ggtgtacaca     1140

ctgcctccaa gtcgcgacga gctgaccaag aatcaggtct ccctgacatg tctggtgaaa     1200

ggcttctatc catcagatat cgccgtggag tgggaaagca acgggcagcc cgaaaacaat     1260

tacaagacca caccccctgt gctggactct gatggcagtt tctttctgta ttctaagctg     1320

accgtggaca aaagtagatg gcagcagggg aatgtctttt catgtagcgt gatgcacgag     1380

gccctgcaca accattacac acagaagtcc ctgtctctga gtcccggaaa gaggggccgc     1440

aaacggagat cagggagcgg agctactaat ttcagcctgc tgaaacaggc aggggatgtg     1500

gaggaaaacc ccggacctat ggcttggacc ccactgttcc tgtttctgct gacatgctgt     1560

cccgggggca gcaattctca gagtgtcctg acacagccac catcagtgag cggagcacca     1620

ggacagaggg tgaccatctc ctgcacaggc agcagcagca acattggcgc cgggtacgac     1680

gtgcattggt atcagcagct gcccggcacc gctcctaagc tgctgatctg tggcaacaat     1740

aaccgcccat ctggggtgcc cgatcgattc tccggctcta aaagtgggac ttcagccagc     1800

ctggctatta ccggcctgca ggccgaggac gaagctgatt actattgcca gagctacgac     1860

tcaagcctga ccggagtcgt gttcggagga ggaaccaagc tgacagtcct gggacagcct     1920

aaagccgctc caagcgtgac actgtttcct ccatcctctg aggaactgca ggcaaacaag     1980

gccaccctgg tgtgcctgat ttccgacttc taccccgggg cagtcactgt ggcttggaag     2040

gcagatagtt cacctgtcaa agccggagtg gagactacca caccatcaaa gcagagcaat     2100

aacaaatacg cagccagctc ctatctgtcc ctgacccctg agcagtggaa gtctcacaaa     2160

tcctattctt gccaggtcac tcacgaagga agcactgtgg agaaaactgt cgcaccaacc     2220

gaatgtagtt gataactcga g                                               2241


<210>  45
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of anti-DENV Human IgG

<400>  45

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ala His Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Asn Phe 
        35                  40                  45              


Ser Thr Asn Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser His Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Val Gly Val Leu Thr Trp Pro Val Asn Ala Glu 
        115                 120                 125             


Tyr Phe His His Trp Gly Gln Gly Ser Leu Val Ser Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Ala Trp Thr Pro Leu Phe Leu Phe Leu 
            500                 505                 510         


Leu Thr Cys Cys Pro Gly Gly Ser Asn Ser Gln Ser Val Leu Thr Gln 
        515                 520                 525             


Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys 
    530                 535                 540                 


Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr 
545                 550                 555                 560 


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Cys Gly Asn Asn 
                565                 570                 575     


Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
            580                 585                 590         


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala 
        595                 600                 605             


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Thr Gly Val Val Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
625                 630                 635                 640 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
                645                 650                 655     


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
            660                 665                 670         


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
        675                 680                 685             


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
    690                 695                 700                 


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
705                 710                 715                 720 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
                725                 730                 735     


Glu Cys Ser 
            


<210>  46
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Heavy Chain

<400>  46

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ala Gln Val Gln Leu Val Gln Ser Gly Ala 
            20                  25                  30          


Val Ile Lys Thr Pro Gly Ser Ser Val Lys Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gly Tyr Asn Phe Arg Asp Tyr Ser Ile His Trp Val Arg Leu Ile Pro 
    50                  55                  60                  


Asp Lys Gly Phe Glu Trp Ile Gly Trp Ile Lys Pro Leu Trp Gly Ala 
65                  70                  75                  80  


Val Ser Tyr Ala Arg Gln Leu Gln Gly Arg Val Ser Met Thr Arg Gln 
                85                  90                  95      


Leu Ser Gln Asp Pro Asp Asp Pro Asp Trp Gly Val Ala Tyr Met Glu 
            100                 105                 110         


Phe Ser Gly Leu Thr Pro Ala Asp Thr Ala Glu Tyr Phe Cys Val Arg 
        115                 120                 125             


Arg Gly Ser Cys Asp Tyr Cys Gly Asp Phe Pro Trp Gln Tyr Trp Cys 
    130                 135                 140                 


Gln Gly Thr Val Val Val Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
145                 150                 155                 160 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                165                 170                 175     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            180                 185                 190         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        195                 200                 205             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    210                 215                 220                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
225                 230                 235                 240 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
            260                 265 


<210>  47
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG Light Chain

<400>  47

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ala Gln Val Gln Ile Val Leu Thr Gln Ser 
            20                  25                  30          


Pro Gly Ile Leu Ser Leu Ser Pro Gly Glu Thr Ala Thr Leu Phe Cys 
        35                  40                  45              


Lys Ala Ser Gln Gly Gly Asn Ala Met Thr Trp Tyr Gln Lys Arg Arg 
    50                  55                  60                  


Gly Gln Val Pro Arg Leu Leu Ile Tyr Asp Thr Ser Arg Arg Ala Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Val Gly Ser Gly Ser Gly Thr Asp Phe Phe 
                85                  90                  95      


Leu Thr Ile Asn Lys Leu Asp Arg Glu Asp Phe Ala Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Phe Glu Phe Phe Gly Leu Gly Ser Glu Leu Glu Val His Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Tyr Pro Tyr Asp Val Pro 
225                 230                 235                 240 


Asp Tyr Ala 
            


<210>  48
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Heavy Chain (VH-CH1) of HIV-1 Env Fab

<400>  48

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ala Gln Val Gln Leu Val Gln Ser Gly Gly 
            20                  25                  30          


Gln Met Lys Lys Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser 
        35                  40                  45              


Gly Tyr Glu Phe Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro 
    50                  55                  60                  


Gly Lys Arg Pro Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala 
65                  70                  75                  80  


Val Asn Tyr Ala Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp 
                85                  90                  95      


Val Tyr Ser Asp Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp 
            100                 105                 110         


Asp Thr Ala Val Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn 
        115                 120                 125             


Trp Asp Phe Glu His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser 
    130                 135                 140                 


Pro Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Ala Glu Pro Lys Ser Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                245                 250                 255     


<210>  49
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Light Chain (VL-CL) of HIV-1 Env Fab

<400>  49

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Gly Ala Gln Val Gln Ile Val Leu Thr Gln Ser 
            20                  25                  30          


Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser Cys 
        35                  40                  45              


Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro Gly 
    50                  55                  60                  


Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala Gly 
65                  70                  75                  80  


Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn Leu 
                85                  90                  95      


Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Tyr Pro Tyr Asp Val 
225                 230                 235                 240 


Pro Asp Tyr Ala 
                


<210>  50
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding HIV-1 PG9 Fab

<400>  50
ggatccgcca ccatggcaag acccctgtgc accctgctgc tgctgatggc aaccctggcc       60

ggagccctgg cacagagcgc cctgacccag cccgcaagcg tctccggctc accaggccag      120

agcatcacta ttagttgcaa cgggactagc aacgacgtgg gaggctatga gagtgtcagc      180

tggtaccagc agcatcccgg aaaagcacca aaagtggtca tctacgatgt cagtaaaagg      240

ccaagtgggg tctcaaatag gttctcaggg agtaaatctg ggaatacagc atctctgacc      300

atctccggac tgggcgcaga agatgaaggc gactactatt gcaaaagcct gacctcaacc      360

agacggcgag tctttgggac aggcaccaag ctgacagtcc tgacagtcgc tgccccctcc      420

gtcttcattt ttccaccttc agatgagcag ctgaaatctg gcactgcatc tgtggtctgc      480

ctgctgaaca acttctatcc acgagaggcc aaggtgcagt ggaaagtgga taacgcactg      540

cagtccggca atagtcagga aagcgtgact gagcaggatt ccaaggacag tacctatagc      600

ctgtccagta cactgaccct gtccaaggct gactacgaaa aacataaggt gtatgcatgt      660

gaagtgactc accagggact gaggtcacca gtcactaagt cttttaacag gggagagtgc      720

ggcgggggag gatctggagg cggcggctct ggagggggag gctcaggggg cggaggaagc      780

ggcggaggag ggtccggagg aggaggcagt cagagactgg tcgaaagcgg gggaggagtg      840

gtgcagcctg ggtcctcact gagactgtca tgcgctgcca gtggctttga tttttcacga      900

cagggaatgc attgggtcag gcaggcaccc ggacagggcc tggaatgggt cgccttcatt      960

aagtacgacg gaagcgagaa gtaccatgcc gactcagtgt ggggaaggct gagcatctca     1020

agggacaact caaaggacac cctgtacctg cagatgaata gcctgagagt ggaagatacc     1080

gctacttatt tctgcgtgcg agaggccgga gggccagatt accggaacgg gtacaattac     1140

tatgatttct acgacggcta ctacaattac cattatatgg atgtctgggg caaaggaact     1200

acagtcaccg tgagctccgc aagtactaag ggaccttccg tgtttcctct ggctcccagt     1260

tccaaaagta catccggagg aacagccgct ctgggatgtc tggtcaagga ctattttccc     1320

gagcccgtga ctgtctcctg gaacagcggg gctctgacaa gcggggtgca cacctttcct     1380

gccgtgctgc agtccagtgg gctgtacagt ctgtctagtg tcgtcactgt gccaagctca     1440

agtctgggga cccagacata catttgtaat gtgaaccata aaccctcaaa caccaaagtg     1500

gacaagaaag tggaacctaa aagctgataa ctcgag                               1536


<210>  51
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of HIV-1 PG9 Fab

<400>  51

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly 
            20                  25                  30          


Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Asn Gly Thr Ser Asn Asp 
        35                  40                  45              


Val Gly Gly Tyr Glu Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Val Val Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val 
65                  70                  75                  80  


Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr 
                85                  90                  95      


Ile Ser Gly Leu Gly Ala Glu Asp Glu Gly Asp Tyr Tyr Cys Lys Ser 
            100                 105                 110         


Leu Thr Ser Thr Arg Arg Arg Val Phe Gly Thr Gly Thr Lys Leu Thr 
        115                 120                 125             


Val Leu Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Arg Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Val Val Gln Pro Gly Ser Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Asp Phe Ser Arg Gln Gly Met His Trp Val Arg Gln 
    290                 295                 300                 


Ala Pro Gly Gln Gly Leu Glu Trp Val Ala Phe Ile Lys Tyr Asp Gly 
305                 310                 315                 320 


Ser Glu Lys Tyr His Ala Asp Ser Val Trp Gly Arg Leu Ser Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asp Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Val Glu Asp Thr Ala Thr Tyr Phe Cys Val Arg Glu Ala Gly Gly Pro 
        355                 360                 365             


Asp Tyr Arg Asn Gly Tyr Asn Tyr Tyr Asp Phe Tyr Asp Gly Tyr Tyr 
    370                 375                 380                 


Asn Tyr His Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val 
385                 390                 395                 400 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
                405                 410                 415     


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
            420                 425                 430         


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
        435                 440                 445             


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
    450                 455                 460                 


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
465                 470                 475                 480 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
                485                 490                 495     


Asp Lys Lys Val Glu Pro Lys Ser 
            500                 


<210>  52
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding HIV-1 4E10 Fab

<400>  52
ggatccgcca ccatggcaag acctctgtgc actctgctgc tgctgatggc tactctggcc       60

ggggctctgg ctgagattgt cctgacccag tcccctggca ctcagtcact gtcccccggc      120

gagcgcgcaa ctctgtcctg cagagcaagc cagtccgtcg ggaacaacaa gctggcatgg      180

taccagcagc gcccaggaca ggcacccagg ctgctgatct acggagcaag ctcccggcct      240

agcggagtcg ctgatagatt ctccggaagc ggctccggga ccgatttcac tctgaccatc      300

tccaggctgg aacctgagga ttttgccgtg tattactgtc agcagtacgg gcagagcctg      360

tcaactttcg gccagggaac taaagtcgaa aagagaaccg tggccgcacc aagcgtcttt      420

atttttcccc ctagcgatga acagctgaaa tccgggactg cttccgtggt ctgcctgctg      480

aataacttct atccaagaga ggcaaaggtg cagtggaaag tggacaacgc cctgcagagc      540

ggaaactcac aggaatctgt gacagagcag gactccaagg atagcacata cagtctgtcc      600

tcaactctga ccctgtccaa agctgactat gagaagcata aagtctacgc atgtgaggtg      660

acccaccagg gactgaggtc ccccgtcact aagtccttca atagaggcga gtgcgggggc      720

gggggcagtg gcggaggggg aagtgggggc ggagggagtg gcggcggcgg gagtggcggc      780

ggcggctcag ggggcggcgg ctcccaggtc cagctggtcc agagcggagc cgaggtcaag      840

agaccaggct cttcagtcac cgtgagctgc aaagccagcg gaggctcctt tagcacttac      900

gccctgtcat gggtgcggca ggccccaggc cgaggcctgg agtggatggg cggcgtgatc      960

cccctgctga ccattactaa ctatgcccct agatttggag gccggatcac catcacagct     1020

gacagatcca catccacagc ttacctggag ctgaacagtc tgaggcccga ggacactgca     1080

gtctactact gtgcacgaga aggcaccact ggatgggggt ggctggggaa gcccatcggg     1140

gcttttgcac attggggcgg agggacactg gtgactgtga gctctgccag cactaaaggg     1200

cccagtgtct tccctctggc cccaagttcc aagagtacat cagggggcac cgccgcactg     1260

gggtgtctgg tgaaggatta cttcccagag cccgtgacag tcagttggaa cagcggcgct     1320

ctgaccagtg gggtgcacac tttcccagcc gtgctgcaga gttcagggct gtactccctg     1380

tcctcagtgg tgactgtgcc ctcaagcagt ctggggactc agacttacat ttgtaatgtg     1440

aaccataaac cctcaaatac taaagtggac aaaaaagtgg aaccaaagag ctgataactc     1500

gag                                                                   1503


<210>  53
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of HIV-1 4E10 Fab

<400>  53

Met Ala Arg Pro Leu Cys Thr Leu Leu Leu Leu Met Ala Thr Leu Ala 
1               5                   10                  15      


Gly Ala Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Gln Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Gly Asn Asn Lys Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Pro Ser Gly Val Ala 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Gly Gln Ser Leu Ser Thr Phe Gly Gln Gly Thr Lys Val Glu Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Arg Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
            260                 265                 270         


Ala Glu Val Lys Arg Pro Gly Ser Ser Val Thr Val Ser Cys Lys Ala 
        275                 280                 285             


Ser Gly Gly Ser Phe Ser Thr Tyr Ala Leu Ser Trp Val Arg Gln Ala 
    290                 295                 300                 


Pro Gly Arg Gly Leu Glu Trp Met Gly Gly Val Ile Pro Leu Leu Thr 
305                 310                 315                 320 


Ile Thr Asn Tyr Ala Pro Arg Phe Gly Gly Arg Ile Thr Ile Thr Ala 
                325                 330                 335     


Asp Arg Ser Thr Ser Thr Ala Tyr Leu Glu Leu Asn Ser Leu Arg Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu Gly Thr Thr Gly Trp 
        355                 360                 365             


Gly Trp Leu Gly Lys Pro Ile Gly Ala Phe Ala His Trp Gly Gly Gly 
    370                 375                 380                 


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
385                 390                 395                 400 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                405                 410                 415     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            420                 425                 430         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        435                 440                 445             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    450                 455                 460                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
465                 470                 475                 480 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
                485                 490             


<210>  54
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the HIV-1 VRC01 IgG1 Heavy Chain 
       (VH/CH1/Hinge/CH2/CH3)

<400>  54
ggatccgcca ccatggattg gacatggatt ctgttcctgg tcgccgccgc aactagagtg       60

cattcacagg tgcagctggt gcagtcaggc gggcagatga agaaacccgg cgagagtatg      120

cgaatctcat gccgggctag cgggtacgaa ttcatcgact gtaccctgaa ctggattaga      180

ctggcacctg ggaagaggcc agagtggatg ggatggctga aacctagagg cggggcagtg      240

aattacgcca gaccactgca gggcagggtc actatgaccc gcgacgtgta ttctgatacc      300

gcattcctgg agctgcgaag tctgacagtc gacgatactg ccgtgtactt ctgcacacgg      360

ggcaagaact gtgactataa ttgggatttt gaacactggg gcagggggac acctgtcatt      420

gtgagctccc caagtactaa gggaccctca gtgtttcccc tggccccttc tagtaaaagt      480

acctcaggag gcacagccgc tctgggatgc ctggtgaagg attacttccc tgagccagtc      540

accgtgagtt ggaactcagg cgccctgaca agcggggtcc atacttttcc agctgtgctg      600

cagtcaagcg ggctgtactc cctgtcctct gtggtcacag tgcccagttc aagcctggga      660

acacagactt atatctgtaa cgtcaatcac aagcctagca atactaaagt ggacaagaaa      720

gccgagccta agagctgcga accaaagtcc tgtgataaaa cccatacatg ccctccctgt      780

ccagctcctg aactgctggg cggcccatcc gtgttcctgt ttccacccaa gcccaaagac      840

accctgatga ttagcaggac tcctgaggtc acctgcgtgg tcgtggacgt gtcccacgag      900

gaccccgaag tcaagtttaa ctggtacgtg gatggcgtcg aagtgcataa tgccaagaca      960

aaaccccggg aggaacagta caactctacc tatagagtcg tgagtgtcct gacagtgctg     1020

caccaggact ggctgaacgg gaaggagtat aagtgcaaag tgtctaataa ggccctgcca     1080

gctcccatcg agaaaacaat ttccaaggca aaaggccagc caagggaacc ccaggtgtac     1140

actctgcctc catcccgcga cgagctgact aagaaccagg tctctctgac ctgtctggtg     1200

aaaggattct atccaagcga tatcgccgtg gagtgggaat ccaatggcca gcccgagaac     1260

aattacaaga ccacaccccc tgtgctggac agcgatggct ccttctttct gtattcaaag     1320

ctgaccgtgg ataaaagccg ctggcagcag gggaacgtct ttagctgctc cgtgatgcac     1380

gaagctctgc acaatcatta cacccagaag tctctgagtc tgtcacctgg caagtgataa     1440

ctcgag                                                                1446


<210>  55
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the HIV-1 VRC01 IgG1 Heavy Chain 
       (VH/CH1/CH2/CH3)

<400>  55

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro 
            20                  25                  30          


Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile 
        35                  40                  45              


Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu 
    50                  55                  60                  


Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg 
65                  70                  75                  80  


Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr 
                85                  90                  95      


Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr 
            100                 105                 110         


Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His 
        115                 120                 125             


Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser Pro Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  56
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the HIV-1 VRC01 IgG Light Chain 
       (VL/CL)

<400>  56
ggatccgcca ccatggattg gacttggatt ctgttcctgg tggcagccgc taccagagtc       60

cattccgaaa ttgtgctgac ccagtctccc ggaacactgt ctctgagtcc tggcgagaca      120

gccatcattt cctgtaggac ttctcagtac gggagtctgg catggtatca gcagcgacca      180

ggacaggctc ctcgactggt catctactca ggaagcactc gggcagccgg cattcccgac      240

cgattctccg ggtctcggtg gggacctgat tacaacctga ccatctcaaa tctggaaagc      300

ggagactttg gcgtgtacta ttgccagcag tatgagttct ttgggcaggg aaccaaggtc      360

caggtggaca tcaaacgcac agtcgctgca ccaagcgtgt tcatctttcc accctcagat      420

gaacagctga agtccggcac cgcctctgtg gtgtgcctgc tgaacaattt ctacccccgg      480

gaggcaaagg tccagtggaa agtggacaac gccctgcagt ctggcaatag tcaggagtca      540

gtgactgaac aggacagcaa ggattccacc tattctctgt cctctactct gaccctgagc      600

aaagctgatt acgagaagca caaagtgtat gcatgtgagg tcacccacca gggactgcgg      660

tcacccgtca ccaagagctt caatcgcgga gagtgttgat aactcgag                   708


<210>  57
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the HIV-1 VRC01 IgG Light Chain (VL/CL)

<400>  57

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser 
            20                  25                  30          


Pro Gly Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser 
        35                  40                  45              


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile 
    50                  55                  60                  


Tyr Ser Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Arg Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser 
                85                  90                  95      


Gly Asp Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln 
            100                 105                 110         


Gly Thr Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    130                 135                 140                 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
145                 150                 155                 160 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                165                 170                 175     


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            180                 185                 190         


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        195                 200                 205             


Glu Val Thr His Gln Gly Leu Arg Ser Pro Val Thr Lys Ser Phe Asn 
    210                 215                 220                 


Arg Gly Glu Cys 
225             


<210>  58
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the Heavy Chain (VH-CH1) of the 
       CHIKV-Env-Fab

<400>  58
ggatccgcca ccatggattg gacatggagg attctgtttc tggtcgccgc cgctactgga       60

actcacgctc aggtgcagct ggtgcagtca gggtccgaac tgaagaaacc aggggcatct      120

gtgaaggtca gttgcaaagc ctcaggctac accctgacac ggtatgccat gacttgggtg      180

cgccaggctc ctggacaggg actggagtgg atgggctgga tcaacactta caccggaaat      240

ccaacttatg tgcaggggtt caccggccga ttcgtgtttt ctctggacac ttccgtctct      300

accgcctttc tgcacattac aagtctgaag gcagaggaca ctgccgtgta cttctgcgct      360

agggaaggcg gagcaagagg ctttgattat tggggccagg gaaccctggt gacagtcagc      420

tccgccagca caaagggacc ctccgtgttc ccactggctc cctctagtaa aagtacatca      480

gggggcactg ccgctctggg atgtctggtc aaagattact tccccgaacc tgtgaccgtc      540

agctggaact ccggagctct gaccagcggg gtgcatacat ttcccgcagt cctgcagtca      600

agcggactgt actccctgtc ctctgtggtc acagtgccta gttcaagcct ggggacacag      660

acttatatct gtaatgtgaa ccataagcca agcaacacca aagtggacaa aaaagtggaa      720

cctaagagct gctgataact cgag                                             744


<210>  59
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Heavy Chain (VH-CH1) of the 
       CHIKV-Env-Fab

<400>  59

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Leu 
        35                  40                  45              


Thr Arg Tyr Ala Met Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Asn Pro Thr Tyr Val 
65                  70                  75                  80  


Gln Gly Phe Thr Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Ser 
                85                  90                  95      


Thr Ala Phe Leu His Ile Thr Ser Leu Lys Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Gly Gly Ala Arg Gly Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


<210>  60
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding the Light Chain (VL-CL) of the 
       CHIKV-Env-Fab

<400>  60
ggatccgcca ccatggcatg gaccccactg ttcctgttcc tgctgacttg ttgtcctggc       60

gggagcaatt cacagagcgt cctgacccag cccccttctg tgtccggagc accaggacag      120

cgagtcacaa tctcttgcac tggaagctcc tctaacattg gggccagcca cgacgtgcat      180

tggtaccagc agctgccagg gaccgctccc acactgctga tctatgtgaa ctctaatagg      240

cctagtggcg tcccagatag attttcaggg agcaagtccg gcacctctgc tagtctggca      300

attacaggac tgcaggctga ggacgaagca gattactatt gccagagtta cgactcaaac      360

ctgtcaggca gcgcagtgtt cggaggagga actaagctga ccgtcctggg acagcccaaa      420

gccgctcctt ctgtgaccct gtttccccct agttcagagg aactgcaggc caacaaggct      480

actctggtgt gtctgatctc cgacttctac cctggagcag tgaccgtcgc atggaaggcc      540

gatagctccc cagtgaaagc tggggtcgag accacaactc ccagcaagca gtccaacaac      600

aagtacgcag cctctagtta tctgtcactg acacctgaac agtggaagag ccacaaatcc      660

tattcttgcc aagtgactca tgagggcagt accgtggaaa agacagtcgc cccaactgag      720

tgttcctgat aactcgag                                                    738


<210>  61
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of the Light Chain (VL-CL) of the 
       CHIKV-Env-Fab

<400>  61

Met Ala Trp Thr Pro Leu Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly 
1               5                   10                  15      


Gly Ser Asn Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly 
            20                  25                  30          


Ala Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn 
        35                  40                  45              


Ile Gly Ala Ser His Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr 
    50                  55                  60                  


Ala Pro Thr Leu Leu Ile Tyr Val Asn Ser Asn Arg Pro Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala 
                85                  90                  95      


Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
            100                 105                 110         


Tyr Asp Ser Asn Leu Ser Gly Ser Ala Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235             


<210>  62
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding HIV-1 Env-4E10 Ig

<400>  62
ggatccgcca ccatggattg gacatggagg attctgtttc tggtcgccgc cgctacagga       60

actcacgccc aggtgcagct ggtgcagtca ggagccgaag tgaagcgacc aggcagctcc      120

gtcactgtgt cctgcaaagc atctggcgga tcattcagca cctacgccct gagctgggtg      180

agacaggctc ctggacgagg actggaatgg atgggaggcg tcatcccact gctgacaatt      240

actaactacg ccccccgatt tcagggcagg atcaccatta cagcagaccg ctccacttct      300

accgcctatc tggagctgaa tagcctgaga ccagaagata ccgcagtgta ctattgcgcc      360

cgggagggaa ccacaggatg gggatggctg ggaaagccca tcggggcttt cgcacactgg      420

ggccagggaa ccctggtcac agtgtctagt gccagcacaa agggcccctc cgtgtttccc      480

ctggctcctt caagcaaaag tacttcagga gggaccgccg ctctgggatg tctggtgaag      540

gactacttcc ctgagccagt caccgtgtcc tggaactctg gcgctctgac ctccggagtg      600

catacatttc ccgcagtcct gcagtcctct gggctgtact ctctgagttc agtggtcact      660

gtgcctagct cctctctggg cacacagact tatatctgca acgtgaatca caagccctcc      720

aataccaaag tcgacaagaa agtggaacct aagtcttgtg ataaaaccca tacatgccca      780

ccttgtccag cacctgagct gctgggcgga ccttccgtgt tcctgtttcc acccaagcca      840

aaagacacac tgatgattag ccggacacct gaagtgactt gtgtggtcgt ggacgtcagc      900

cacgaggacc ccgaagtgaa gttcaactgg tacgtggatg gcgtcgaggt gcataatgcc      960

aagaccaaac ccagggagga acagtacaac tctacttata gggtcgtgag tgtcctgacc     1020

gtgctgcacc aggactggct gaacgggaag gagtataagt gcaaagtgtc caataaggcc     1080

ctgccagctc ccatcgagaa aacaatttct aaggctaaag gccagccacg cgaaccccag     1140

gtgtacactc tgcctcccag cagggacgag ctgaccaaga accaggtgag tctgacatgt     1200

ctggtcaaag gcttctatcc aagcgatatc gccgtggagt gggaatccaa tggacagccc     1260

gaaaacaatt acaagactac cccccctgtg ctggacagtg atggatcatt ctttctgtat     1320

tccaagctga ccgtggacaa atctcgctgg cagcagggga acgtctttag ctgctccgtg     1380

atgcacgagg ccctgcacaa tcattacaca cagaagtctc tgagtctgtc accaggcaag     1440

cggggacgca aaaggagaag cgggtccggc gctactaact tcagcctgct gaaacaggca     1500

ggggatgtgg aggaaaatcc tggcccaatg gtcctgcaga cccaggtgtt tatctcactg     1560

ctgctgtgga ttagcggggc ttatggcgaa atcgtgctga ctcagagccc cggaacccag     1620

tctctgagtc ctggggagcg cgctacactg agctgtcgag catcacagag cgtggggaac     1680

aataagctgg catggtacca gcagaggcct ggccaggctc caagactgct gatctatggc     1740

gcaagttcac ggcctagcgg agtggcagac cgcttctccg gatctgggag tggcaccgat     1800

tttactctga ccattagcag gctggagcca gaagacttcg ctgtgtacta ttgccagcag     1860

tacggccagt cactgagcac atttggacag gggactaagg tcgaaaaaag aaccgtggca     1920

gccccaagtg tcttcatttt tccaccctca gacgagcagc tgaagagtgg aacagcctca     1980

gtcgtgtgtc tgctgaacaa tttctacccc agggaggcca aggtccagtg gaaagtggat     2040

aacgctctgc agagcggcaa ttcccaggag tctgtgacag aacaggacag taaggattca     2100

acttatagcc tgagctccac actgactctg tccaaagcag attacgagaa gcacaaagtg     2160

tatgcctgcg aagtcaccca tcagggactg tctagtcctg tgacaaagtc ttttaacaga     2220

ggggagtgat aactcgag                                                   2238


<210>  63
<211>  2328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding HIV-1 Env-PG9 Ig

<400>  63
ggatccgcca ccatggactg gacttggagg attctgtttc tggtcgccgc cgcaactgga       60

actcacgctg aatttggact gtcatgggtc tttctggtgg cctttctgcg aggggtccag      120

tgccagaggc tggtggagtc cggaggagga gtggtccagc caggcagctc cctgcgactg      180

agttgtgccg cttcagggtt cgacttttct agacagggca tgcactgggt gcggcaggca      240

ccaggacagg gactggagtg ggtggctttc atcaagtacg acggaagtga aaaatatcat      300

gccgattcag tgtgggggcg gctgtcaatt agccgcgaca actccaagga taccctgtac      360

ctgcagatga attctctgag ggtcgaggac acagctactt atttctgcgt gagggaagca      420

ggcggacctg attacagaaa cgggtataat tactatgact tttacgatgg ctactataac      480

taccactata tggacgtgtg gggcaaggga accacagtca cagtgtctag tgcatcaact      540

aaaggcccaa gcgtgtttcc cctggcccct tcaagcaagt ccacttctgg aggaaccgca      600

gcactgggat gtctggtgaa ggattacttc cctgagccag tcaccgtgag ttggaactca      660

ggcgccctga ctagcggagt ccataccttt cctgctgtgc tgcagtcctc tgggctgtac      720

agcctgagtt cagtggtcac agtgccaagc tcctctctgg gcacccagac atatatctgc      780

aacgtgaatc acaagcctag caatactaag gtcgacaaaa gagtggaacc aaagagctgt      840

gataaaactc atacctgccc accttgtcca gcacctgagc tgctgggagg gccttccgtg      900

ttcctgtttc cacccaagcc aaaagacacc ctgatgatta gccggacacc agaagtcact      960

tgcgtggtcg tggacgtgag ccacgaggac cccgaagtca agtttaactg gtacgtggat     1020

ggcgtcgagg tgcataatgc taagacaaaa ccacgggagg aacagtacaa ctccacatat     1080

cgcgtcgtgt ctgtcctgac tgtgctgcac caggactggc tgaacggcaa ggagtataag     1140

tgcaaagtgt ccaataaggc actgccagcc cccatcgaga aaaccatttc taaggccaaa     1200

ggccagccac gagaacccca ggtgtacaca ctgcctccaa gtagggacga gctgactaag     1260

aaccaggtct ctctgacctg tctggtgaaa ggcttctatc cctctgatat cgctgtggag     1320

tgggaaagta atggacagcc tgaaaacaat tacaagacta ccccccctgt gctggacagc     1380

gatggcagct tcttcctgta tagcaagctg accgtggaca aatccagatg gcagcagggg     1440

aacgtcttta gttgctcagt gatgcacgag gcactgcaca atcattacac ccagaaaagc     1500

ctgtccctgt ctcctggcaa gaggggaaga aaaaggagaa gtgggtcagg cgcaacaaac     1560

ttcagcctgc tgaagcaggc cggagatgtg gaggaaaatc ctgggccaat ggcttggacc     1620

cccctgttcc tgtttctgct gacatgctgt cctggcggaa gcaactccca gtctgcactg     1680

acacagccag caagtgtgtc agggagccca ggacagagca tcaccatttc ctgtaacggc     1740

acaagcaatg acgtcggggg ctacgagtcc gtgtcttggt atcagcagca tcctggaaag     1800

gccccaaaag tcgtgatcta cgatgtcagc aaacgcccct ctggggtgag taaccgattc     1860

agtggatcaa agagcgggaa taccgcttct ctgacaatta gtggcctgca ggcagaggac     1920

gaaggagatt actattgcaa atcactgaca agcactcggc gccgagtctt cggaaccggg     1980

acaaagctga ctgtgctggg ccagcccaaa gctgcaccta gcgtgaccct gtttccaccc     2040

agttcagagg aactgcaggc taataaggca acactggtgt gtctgatctc cgacttctac     2100

cctggcgctg tcactgtggc ctggaaggct gatagctccc cagtcaaagc aggagtggaa     2160

acaactaccc cctccaagca gtctaacaac aagtacgccg cttctagtta tctgtcactg     2220

actcccgagc agtggaagag ccacaaatcc tattcttgcc aggtgaccca tgagggctcc     2280

actgtcgaaa agaccgtggc ccctacagag tgttcttgat aactcgag                  2328


<210>  64
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence Encoding VRC01 IgG

<400>  64
ggatccgcca ccatggattg gacatggatt ctgttcctgg tcgccgccgc aactagagtg       60

cattcacagg tgcagctggt gcagtcaggc gggcagatga agaaacccgg cgagagtatg      120

cgaatctcat gccgggctag cgggtacgaa ttcatcgact gtaccctgaa ctggattaga      180

ctggcacctg ggaagaggcc agagtggatg ggatggctga aacctagagg cggggcagtg      240

aattacgcca gaccactgca gggcagggtc actatgaccc gcgacgtgta ttctgatacc      300

gcattcctgg agctgcgaag tctgacagtc gacgatactg ccgtgtactt ctgcacacgg      360

ggcaagaact gtgactataa ttgggatttt gaacactggg gcagggggac acctgtcatt      420

gtgagctccc caagtactaa gggaccctca gtgtttcccc tggccccttc tagtaaaagt      480

acctcaggag gcacagccgc tctgggatgc ctggtgaagg attacttccc tgagccagtc      540

accgtgagtt ggaactcagg cgccctgaca agcggggtcc atacttttcc agctgtgctg      600

cagtcaagcg ggctgtactc cctgtcctct gtggtcacag tgcccagttc aagcctggga      660

acacagactt atatctgtaa cgtcaatcac aagcctagca atactaaagt ggacaagaaa      720

gccgagccta agagctgcga accaaagtcc tgtgataaaa cccatacatg ccctccctgt      780

ccagctcctg aactgctggg cggcccatcc gtgttcctgt ttccacccaa gcccaaagac      840

accctgatga ttagcaggac tcctgaggtc acctgcgtgg tcgtggacgt gtcccacgag      900

gaccccgaag tcaagtttaa ctggtacgtg gatggcgtcg aagtgcataa tgccaagaca      960

aaaccccggg aggaacagta caactctacc tatagagtcg tgagtgtcct gacagtgctg     1020

caccaggact ggctgaacgg gaaggagtat aagtgcaaag tgtctaataa ggccctgcca     1080

gctcccatcg agaaaacaat ttccaaggca aaaggccagc caagggaacc ccaggtgtac     1140

actctgcctc catcccgcga cgagctgact aagaaccagg tctctctgac ctgtctggtg     1200

aaaggattct atccaagcga tatcgccgtg gagtgggaat ccaatggcca gcccgagaac     1260

aattacaaga ccacaccccc tgtgctggac agcgatggct ccttctttct gtattcaaag     1320

ctgaccgtgg ataaaagccg ctggcagcag gggaacgtct ttagctgctc cgtgatgcac     1380

gaagctctgc acaatcatta cacccagaag tctctgagtc tgtcacctgg caagagggga     1440

cgaaaacgga gaagcggcag cggagctaca aacttcagcc tgctgaaaca ggcaggcgac     1500

gtggaggaaa atcctgggcc aatggattgg acttggattc tgttcctggt ggcagccgct     1560

accagagtcc attccgaaat tgtgctgacc cagtctcccg gaacactgtc tctgagtcct     1620

ggcgagacag ccatcatttc ctgtaggact tctcagtacg ggagtctggc atggtatcag     1680

cagcgaccag gacaggctcc tcgactggtc atctactcag gaagcactcg ggcagccggc     1740

attcccgacc gattctccgg gtctcggtgg ggacctgatt acaacctgac catctcaaat     1800

ctggaaagcg gagactttgg cgtgtactat tgccagcagt atgagttctt tgggcaggga     1860

accaaggtcc aggtggacat caaacgcaca gtcgctgcac caagcgtgtt catctttcca     1920

ccctcagatg aacagctgaa gtccggcacc gcctctgtgg tgtgcctgct gaacaatttc     1980

tacccccggg aggcaaaggt ccagtggaaa gtggacaacg ccctgcagtc tggcaatagt     2040

caggagtcag tgactgaaca ggacagcaag gattccacct attctctgtc ctctactctg     2100

accctgagca aagctgatta cgagaagcac aaagtgtatg catgtgaggt cacccaccag     2160

ggactgcggt cacccgtcac caagagcttc aatcgcggag agtgttgata actcgag        2217


<210>  65
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV snapi nucleic acid sequence

<400>  65
ggatccgcca ccatggactg gacttggatt ctgtttctgg tcgccgccgc tacccgagtg       60

cattcacagg tgcagctgca gcagcctggg gccgctctgg tgaagccagg agctagcgca      120

atgatgtcct gcaaagcctc tggctacact ttcacctcct attggatcac ctgggtgaag      180

cagcgacctg gacagggact ggagtggatc ggcgacatct acccaggcac cgggagaaca      240

atctacaagg aaaaattcaa gacaaaagcc acactgactg tggacaccag ctcctctaca      300

gcttttatgc agctgaacag cctgacttcc gaggatagcg ccgtgtacta ttgcgcaaga      360

ggatacggct ctccttacta tgccctggac tattgggggc agggaactag cgtcaccgtg      420

agttcagcat ctaccaaggg accaagcgtg ttcccactgg cacctagctc caaatccact      480

tctggcggga ccgccgctct gggatgtctg gtgaaggatt acttccctga gccagtcaca      540

gtgagttgga actcaggggc tctgaccagc ggagtccaca catttcctgc agtgctgcag      600

tctagtggac tgtactccct gtcaagcgtg gtcactgtcc catcctctag tctgggcacc      660

cagacatata tctgcaacgt gaatcacaag ccatccaata ccaaagtcga taagaaagtg      720

gagcccaagt cttgtgacaa aactcatacc tgccctccct gtccagcacc tgaactgctg      780

ggaggcccaa gcgtgttcct gtttccaccc aagcctaaag acaccctgat gattagcagg      840

acaccagagg tcacttgcgt ggtcgtggac gtgagccacg aagaccccga ggtcaagttc      900

aactggtacg tggatggcgt cgaagtgcat aatgccaaga caaaaccccg ggaggaacag      960

tacaactcaa cctatcgggt cgtgagcgtc ctgacagtgc tgcaccagga ctggctgaac     1020

ggaaaggagt acaagtgcaa agtgtctaat aaggccctgc cagctcccat cgaaaaaacc     1080

attagcaagg ctaaaggcca gccaagagag ccccaggtgt acacactgcc tccatcaagg     1140

gacgaactga caaagaacca ggtcagcctg acttgtctgg tgaaaggctt ctatcccagc     1200

gatatcgcag tggaatggga gtccaatggg cagcctgaga acaattacaa gaccacaccc     1260

cctgtgctgg acagcgatgg gtccttcttt ctgtattcca agctgacagt ggataaatct     1320

cggtggcagc agggaaacgt ctttagttgc tcagtgatgc acgaagccct gcacaatcat     1380

tacactcaga agagcctgtc cctgtctccc ggaaagaggg gccgcaaacg gagaagtggc     1440

tcaggggcaa ccaacttctc tctgctgaaa caggccggcg atgtggagga aaatcctggg     1500

ccaatggact ggacatggat tctgttcctg gtggcagccg ctacaagggt ccattccgac     1560

attgtgctga ctcagtctcc tgcaagtctg gccgtgtctc agggacagcg agcaaccatc     1620

agttgtaagg ctagccagtc cgtcgactac gatggggaca gttacgtgaa ctggtatcag     1680

cagaagcctg gacagtcccc aaaactgctg atctatgatg ctagtaatct ggagtcaggc     1740

attcccgcac gattctctgg aagtggctca gggacagact tcaccctgaa cattcaccct     1800

gtcgaggaag aggacgtggc tacctactat tgccaggaaa gcaatgagga cccccgcact     1860

ttcgggggag gcaccaagct ggagatcaaa cgaactgtcg cagcccccag cgtgttcatc     1920

tttccaccct cagacgaaca gctgaagagc ggaaccgcat ccgtggtgtg cctgctgaac     1980

aacttctacc cccgcgaggc caaggtccag tggaaagtgg ataacgctct gcagtcaggc     2040

aatagccagg aatccgtgac tgagcaggat tctaaggaca gtacctattc actgtcaagc     2100

acactgactc tgagcaaagc agactacgaa aagcataaag tgtatgcctg cgaagtcacc     2160

caccaggggc tgaggtctcc agtcactaag tctttcaaca gaggggaatg ctgataactc     2220

gag                                                                   2223


<210>  66
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DVSF-1 WT nucleic acid sequence

<400>  66
ggatccgcca ccatggactg gacttggagg attctgtttc tggtcgccgc cgctactggg       60

actcacgctc aggcacatct ggtcgaatct ggaggaggag tggtccagcc tggccgatcc      120

ctgcgactgt cttgcgcagc tagcgccttc aacttcagca caaacgcaat gcactgggtg      180

cgacaggcac caggcaaggg actggagtgg gtcgctgtga tctcatacga cggaagccat      240

aagtactatg cagattctgt gaaaggccgg ttcaccattt ccagggacaa ttctaagaac      300

accctgtatc tgcagatgaa tagcctgcgc gcagccgata ccgcagtgta ctattgcgca      360

actgtcggcg tgctgacctg gccagtgaac gccgaatact ttcaccattg gggacagggc      420

agtctggtct cagtgagctc cgcaagtact aagggaccat cagtgttccc actggcaccc      480

tctagtaaat ctactagtgg cgggaccgct gcactgggat gtctggtgaa ggactatttc      540

cccgagcctg tcaccgtgag ctggaattcc ggagccctga caagcggcgt ccacactttt      600

cccgctgtgc tgcagtcaag cggactgtac tccctgtcct ctgtggtcac tgtgcctagt      660

tcaagcctgg gcactcagac ctatatctgc aatgtgaacc acaagccctc taacaccaaa      720

gtcgacaaga aagtggaacc taagagctgt gataaaacac atacttgccc accttgtcca      780

gcaccagagc tgctgggagg accaagcgtg ttcctgtttc cacccaagcc taaagacaca      840

ctgatgatta gccggacacc tgaagtcact tgcgtggtcg tggacgtgtc ccacgaggac      900

cccgaagtca agtttaattg gtacgtggat ggcgtcgagg tgcataacgc caagaccaaa      960

ccccgggagg aacagtacaa tagcacatat agagtcgtgt ccgtcctgac tgtgctgcat     1020

caggattggc tgaatgggaa ggagtataag tgcaaagtgt ctaacaaggc tctgcctgca     1080

ccaatcgaga aaaccattag caaggctaaa ggccagccta gggaaccaca ggtgtacaca     1140

ctgcctccaa gtcgcgacga gctgaccaag aatcaggtct ccctgacatg tctggtgaaa     1200

ggcttctatc catcagatat cgccgtggag tgggaaagca acgggcagcc cgaaaacaat     1260

tacaagacca caccccctgt gctggactct gatggcagtt tctttctgta ttctaagctg     1320

accgtggaca aaagtagatg gcagcagggg aatgtctttt catgtagcgt gatgcacgag     1380

gccctgcaca accattacac acagaagtcc ctgtctctga gtcccggaaa gaggggccgc     1440

aaacggagat cagggagcgg agctactaat ttcagcctgc tgaaacaggc aggggatgtg     1500

gaggaaaacc ccggacctat ggcttggacc ccactgttcc tgtttctgct gacatgctgt     1560

cccgggggca gcaattctca gagtgtcctg acacagccac catcagtgag cggagcacca     1620

ggacagaggg tgaccatctc ctgcacaggc agcagcagca acattggcgc cgggtacgac     1680

gtgcattggt atcagcagct gcccggcacc gctcctaagc tgctgatctg tggcaacaat     1740

aaccgcccat ctggggtgcc cgatcgattc tccggctcta aaagtgggac ttcagccagc     1800

ctggctatta ccggcctgca ggccgaggac gaagctgatt actattgcca gagctacgac     1860

tcaagcctga ccggagtcgt gttcggagga ggaaccaagc tgacagtcct gggacagcct     1920

aaagccgctc caagcgtgac actgtttcct ccatcctctg aggaactgca ggcaaacaag     1980

gccaccctgg tgtgcctgat ttccgacttc taccccgggg cagtcactgt ggcttggaag     2040

gcagatagtt cacctgtcaa agccggagtg gagactacca caccatcaaa gcagagcaat     2100

aacaaatacg cagccagctc ctatctgtcc ctgacccctg agcagtggaa gtctcacaaa     2160

tcctattctt gccaggtcac tcacgaagga agcactgtgg agaaaactgt cgcaccaacc     2220

gaatgtagtt gataactcga g                                               2241


<210>  67
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVSF-1 WT amino acid sequence

<400>  67

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ala His Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Asn Phe 
        35                  40                  45              


Ser Thr Asn Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser His Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Val Gly Val Leu Thr Trp Pro Val Asn Ala Glu 
        115                 120                 125             


Tyr Phe His His Trp Gly Gln Gly Ser Leu Val Ser Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Ala Trp Thr Pro Leu Phe Leu Phe Leu 
            500                 505                 510         


Leu Thr Cys Cys Pro Gly Gly Ser Asn Ser Gln Ser Val Leu Thr Gln 
        515                 520                 525             


Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys 
    530                 535                 540                 


Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr 
545                 550                 555                 560 


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Cys Gly Asn Asn 
                565                 570                 575     


Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
            580                 585                 590         


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala 
        595                 600                 605             


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Thr Gly Val Val Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
625                 630                 635                 640 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
                645                 650                 655     


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
            660                 665                 670         


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
        675                 680                 685             


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
    690                 695                 700                 


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
705                 710                 715                 720 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
                725                 730                 735     


Glu Cys Ser 
            


<210>  68
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DVSF-1 LALA nucleic acid sequence

<400>  68
ggatccgcca ccatggactg gacttggagg attctgtttc tggtcgccgc cgctactggg       60

actcacgctc aggcacatct ggtcgaatct ggaggaggag tggtccagcc tggccgatcc      120

ctgcgactgt cttgcgcagc tagcgccttc aacttcagca caaacgcaat gcactgggtg      180

cgacaggcac caggcaaggg actggagtgg gtcgctgtga tctcatacga cggaagccat      240

aagtactatg cagattctgt gaaaggccgg ttcaccattt ccagggacaa ttctaagaac      300

accctgtatc tgcagatgaa tagcctgcgc gcagccgata ccgcagtgta ctattgcgca      360

actgtcggcg tgctgacctg gccagtgaac gccgaatact ttcaccattg gggacagggc      420

agtctggtct cagtgagctc cgcaagtact aagggaccat cagtgttccc actggcaccc      480

tctagtaaat ctactagtgg cgggaccgct gcactgggat gtctggtgaa ggactatttc      540

cccgagcctg tcaccgtgag ctggaattcc ggagccctga caagcggcgt ccacactttt      600

cccgctgtgc tgcagtcaag cggactgtac tccctgtcct ctgtggtcac tgtgcctagt      660

tcaagcctgg gcactcagac ctatatctgc aatgtgaacc acaagccctc taacaccaaa      720

gtcgacaaga aagtggaacc taagagctgt gataaaacac atacttgccc accttgtcca      780

gcaccagagg cagctggagg accaagcgtg ttcctgtttc cacccaagcc taaagacaca      840

ctgatgatta gccggacacc tgaagtcact tgcgtggtcg tggacgtgtc ccacgaggac      900

cccgaagtca agtttaattg gtacgtggat ggcgtcgagg tgcataacgc caagaccaaa      960

ccccgggagg aacagtacaa tagcacatat agagtcgtgt ccgtcctgac tgtgctgcat     1020

caggattggc tgaatgggaa ggagtataag tgcaaagtgt ctaacaaggc tctgcctgca     1080

ccaatcgaga aaaccattag caaggctaaa ggccagccta gggaaccaca ggtgtacaca     1140

ctgcctccaa gtcgcgacga gctgaccaag aatcaggtct ccctgacatg tctggtgaaa     1200

ggcttctatc catcagatat cgccgtggag tgggaaagca acgggcagcc cgaaaacaat     1260

tacaagacca caccccctgt gctggactct gatggcagtt tctttctgta ttctaagctg     1320

accgtggaca aaagtagatg gcagcagggg aatgtctttt catgtagcgt gatgcacgag     1380

gccctgcaca accattacac acagaagtcc ctgtctctga gtcccggaaa gaggggccgc     1440

aaacggagat cagggagcgg agctactaat ttcagcctgc tgaaacaggc aggggatgtg     1500

gaggaaaacc ccggacctat ggcttggacc ccactgttcc tgtttctgct gacatgctgt     1560

cccgggggca gcaattctca gagtgtcctg acacagccac catcagtgag cggagcacca     1620

ggacagaggg tgaccatctc ctgcacaggc agcagcagca acattggcgc cgggtacgac     1680

gtgcattggt atcagcagct gcccggcacc gctcctaagc tgctgatctg tggcaacaat     1740

aaccgcccat ctggggtgcc cgatcgattc tccggctcta aaagtgggac ttcagccagc     1800

ctggctatta ccggcctgca ggccgaggac gaagctgatt actattgcca gagctacgac     1860

tcaagcctga ccggagtcgt gttcggagga ggaaccaagc tgacagtcct gggacagcct     1920

aaagccgctc caagcgtgac actgtttcct ccatcctctg aggaactgca ggcaaacaag     1980

gccaccctgg tgtgcctgat ttccgacttc taccccgggg cagtcactgt ggcttggaag     2040

gcagatagtt cacctgtcaa agccggagtg gagactacca caccatcaaa gcagagcaat     2100

aacaaatacg cagccagctc ctatctgtcc ctgacccctg agcagtggaa gtctcacaaa     2160

tcctattctt gccaggtcac tcacgaagga agcactgtgg agaaaactgt cgcaccaacc     2220

gaatgtagtt gataactcga g                                               2241


<210>  69
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVSF-1 LALA amino acid sequence

<400>  69

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ala His Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Asn Phe 
        35                  40                  45              


Ser Thr Asn Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser His Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Val Gly Val Leu Thr Trp Pro Val Asn Ala Glu 
        115                 120                 125             


Tyr Phe His His Trp Gly Gln Gly Ser Leu Val Ser Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Ala Trp Thr Pro Leu Phe Leu Phe Leu 
            500                 505                 510         


Leu Thr Cys Cys Pro Gly Gly Ser Asn Ser Gln Ser Val Leu Thr Gln 
        515                 520                 525             


Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Arg Val Thr Ile Ser Cys 
    530                 535                 540                 


Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Trp Tyr 
545                 550                 555                 560 


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Cys Gly Asn Asn 
                565                 570                 575     


Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
            580                 585                 590         


Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln Ala Glu Asp Glu Ala 
        595                 600                 605             


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Leu Thr Gly Val Val Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
625                 630                 635                 640 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
                645                 650                 655     


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
            660                 665                 670         


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
        675                 680                 685             


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
    690                 695                 700                 


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
705                 710                 715                 720 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
                725                 730                 735     


Glu Cys Ser 
            


<210>  70
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DVSF-2 WT nucleic acid sequence

<400>  70
ggatccgcca ccatggactg gacatggaga atcctgttcc tggtcgccgc cgcaaccggg       60

acacacgccg aagtgcagct ggtggaatct ggagggggat gggtgcagcc aggagggtcc      120

ctgcgactgt cttgcgccgc tagtggcttc actttttcca gatacgacat gcactgggtc      180

aggcaggtga ccggaaaggg cctggaatgg gtgagcgcaa tcaccacagc cggagacaca      240

tactatcccg attctgtgaa gggccggttc accattagtc gggagaacgc caaaagctcc      300

ctgtatctgc agatgaacaa tctgagagct ggcgacaccg cactgtacta ttgcgctagg      360

ggccccccta cagattgctc tagtggacga tgtctgggag tcggagtggg actggaccca      420

tgggggcagg gaacactggt cactgtgtca agcgcctcca caaagggacc ctctgtgttc      480

cctctggctc catcctctaa aagtacttca ggaggaaccg cagcactggg atgtctggtg      540

aaggattact tcccagagcc cgtcaccgtg agctggaact ccggagctct gactagcggc      600

gtccatacct ttcctgcagt gctgcagagt tcaggcctgt acagcctgag ctccgtggtc      660

accgtgccat ctagttcact ggggacccag acatatatct gcaacgtgaa tcacaagcca      720

tctaatacaa aagtcgacaa gaaagtggaa cccaagagtt gtgataaaac tcatacctgc      780

ccaccatgtc ctgcaccaga gctgctggga ggaccatccg tgttcctgtt tcctccaaag      840

cccaaagaca cactgatgat tagcaggaca cccgaagtca cttgcgtggt cgtggacgtg      900

agccacgagg accccgaagt caagtttaac tggtacgtgg atggcgtcga ggtgcataat      960

gccaagacca aaccccggga ggaacagtac aacagtacct atagagtcgt gtcagtcctg     1020

acagtgctgc accaggactg gctgaacggg aaagagtata agtgcaaagt gtccaataag     1080

gcactgcccg cccctatcga gaaaaccatt tctaaggcca aaggacagcc ccgagaacct     1140

caggtgtaca cactgccccc tagccgcgac gagctgacaa agaaccaggt ctccctgact     1200

tgtctggtga aagggttcta tccttcagat atcgccgtgg agtgggaaag caatggacag     1260

ccagaaaaca attacaagac taccccaccc gtgctggact ctgatggcag tttctttctg     1320

tatagcaagc tgaccgtgga caaatcccgc tggcagcagg ggaacgtctt tagctgctcc     1380

gtgatgcatg aggccctgca caatcattac actcagaagt ctctgagtct gtcacctgga     1440

aagaggggac gaaaacgaag aagcggctcc ggagcaacca acttcagcct gctgaaacag     1500

gccggggatg tggaggaaaa tccaggaccc atggcatgga ctcctctgtt cctgtttctg     1560

ctgacctgct gtccaggcgg gagcaacagc tcctacgagg tgacccagcc tccatctgtc     1620

agtgtgtcac ccggccagac cgcttcaatc acatgtagcg gggacaagct gggaaagaaa     1680

tacacaagtt ggtatcagca gaaaccagga cagtcacccc tgctggtcat ctaccaggat     1740

actaagcgcc ctagcggcat tccagaacgg ttcagcggct ccaactctgg gaatacagct     1800

actctgacca tctccggcac ccaggccatg gacgaggctg attactattg ccaggcatgg     1860

gattctacaa ctcacgtcat tttcggaggc gggaccaagc tgacagtgct ggggcagccc     1920

aaagctgcac ctagcgtcac cctgtttccc ccttctagtg aggaactgca ggctaataag     1980

gcaacactgg tgtgtctgat ttccgacttc tacccaggag cagtcactgt ggcatggaag     2040

gctgattcaa gccccgtcaa agccggagtg gaaaccacaa ctccttcaaa gcagagcaac     2100

aacaagtacg ccgcttcctc ttatctgtcc ctgactcccg agcagtggaa gtctcacaaa     2160

agttattcat gccaggtgac ccatgagggc tccactgtcg aaaagaccgt ggcccctaca     2220

gagtgttctt gataactcga g                                               2241


<210>  71
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVSF-2 WT amino acid sequence

<400>  71

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Thr Ala Gly Asp Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Gly Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Pro Thr Asp Cys Ser Ser Gly Arg Cys Leu 
        115                 120                 125             


Gly Val Gly Val Gly Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg 
465                 470                 475                 480 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Trp Thr Pro Leu 
            500                 505                 510         


Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly Gly Ser Asn Ser Ser Tyr 
        515                 520                 525             


Glu Val Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala 
    530                 535                 540                 


Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Lys Lys Tyr Thr Ser Trp 
545                 550                 555                 560 


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Leu Leu Val Ile Tyr Gln Asp 
                565                 570                 575     


Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
            580                 585                 590         


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu 
        595                 600                 605             


Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Thr Thr His Val Ile Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
625                 630                 635                 640 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
                645                 650                 655     


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
            660                 665                 670         


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
        675                 680                 685             


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
    690                 695                 700                 


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
705                 710                 715                 720 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
                725                 730                 735     


Glu Cys Ser 
            


<210>  72
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DVSF-2 LALA nucleic acid sequence

<400>  72
ggatccgcca ccatggactg gacatggaga atcctgttcc tggtcgccgc cgctactggg       60

actcacgccg aagtgcagct ggtcgagagt ggagggggat gggtgcagcc cggcggcagc      120

ctgaggctgt cttgcgccgc tagtggcttc actttttcta gatacgacat gcactgggtc      180

cggcaggtga ccgggaaggg actggaatgg gtgagcgcca tcaccacagc aggggacaca      240

tactatcccg attctgtgaa gggcaggttc accattagta gggagaacgc aaaaagctcc      300

ctgtatctgc agatgaacaa tctgagagcc ggcgacaccg ctctgtacta ttgcgccagg      360

ggccctccca cagattgctc tagtggacgc tgtctgggag tcggagtggg actggaccca      420

tggggacagg ggacactggt caccgtgagc agcgcctcca ctaagggacc aagcgtgttc      480

cctctggcac catcctctaa aagtacttca gggggcaccg cagccctggg atgtctggtg      540

aaggattact tcccagagcc cgtcacagtg agctggaact ccggggccct gacttccgga      600

gtccacacct ttcctgctgt gctgcagagt tcaggcctgt actctctgag ctccgtggtc      660

acagtgccat ctagttcact gggaacccag acatatatct gcaacgtgaa tcacaagcca      720

agtaatacta aagtcgacaa gaaagtggaa cccaagtctt gtgataaaac tcatacctgc      780

ccaccctgtc ctgcaccaga ggctgcagga gggccatccg tgttcctgtt tcctccaaag      840

cccaaagaca ccctgatgat tagccggaca cccgaagtca cttgcgtggt cgtggacgtg      900

tcccacgagg accccgaagt caagtttaac tggtacgtgg atggcgtcga ggtgcataat      960

gccaagacaa aacccaggga ggaacagtac aacagtacct atagagtcgt gtcagtcctg     1020

acagtgctgc accaggactg gctgaacgga aaggagtata agtgcaaagt gtctaataag     1080

gctctgcccg cacctatcga gaaaaccatt agcaaggcca aagggcagcc ccgagaacct     1140

caggtgtaca cactgccccc ttcccgcgac gagctgacaa agaaccaggt ctctctgact     1200

tgtctggtga aaggattcta tccttcagat atcgccgtgg agtgggaaag caatgggcag     1260

ccagaaaaca attacaagac taccccaccc gtgctggact ctgatggcag tttctttctg     1320

tatagcaagc tgaccgtgga caaatcccgc tggcagcagg gaaacgtctt tagctgctcc     1380

gtgatgcatg aggccctgca caatcattac acccagaagt ctctgagtct gtcacctggg     1440

aagcgaggac gaaaaaggag aagcggctcc ggagctacaa acttctccct gctgaaacag     1500

gcaggagatg tggaggaaaa tccagggccc atggcctgga ctcctctgtt cctgtttctg     1560

ctgacctgct gtccaggcgg aagcaacagc tcctacgagg tgacccagcc tccaagcgtg     1620

agcgtgagcc caggccagac cgcttcaatc acatgtagcg gagacaagct ggggaagaaa     1680

tacactagtt ggtatcagca gaaaccaggg cagtcacccc tgctggtcat ctaccaggat     1740

accaagcgcc ctagcggcat tccagaacga ttcagcggct ccaactctgg aaatacagcc     1800

actctgacca tcagcggcac ccaggcaatg gacgaggccg attactattg ccaggcttgg     1860

gattccacaa ctcacgtcat tttcgggggc ggaaccaagc tgacagtgct gggacagccc     1920

aaagccgctc cttccgtcac cctgtttccc ccttctagtg aggaactgca ggccaataag     1980

gccaccctgg tgtgcctgat tagcgacttc taccccggag ctgtcactgt ggcatggaag     2040

gccgattcaa gccccgtcaa agcaggggtg gaaaccacaa ctccttcaaa gcagagcaac     2100

aacaagtacg cagcctcctc ttatctgtcc ctgacccctg agcagtggaa gtctcataaa     2160

agttattcat gtcaggtcac ccatgagggc agcacagtgg aaaaaaccgt ggcaccaaca     2220

gaatgtagct gataactcga g                                               2241


<210>  73
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVSF-2 LALA amino acid sequence

<400>  73

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Trp Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Asp Met His Trp Val Arg Gln Val Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Thr Ala Gly Asp Thr Tyr Tyr Pro Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Gly Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Pro Thr Asp Cys Ser Ser Gly Arg Cys Leu 
        115                 120                 125             


Gly Val Gly Val Gly Leu Asp Pro Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg 
465                 470                 475                 480 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ala Trp Thr Pro Leu 
            500                 505                 510         


Phe Leu Phe Leu Leu Thr Cys Cys Pro Gly Gly Ser Asn Ser Ser Tyr 
        515                 520                 525             


Glu Val Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala 
    530                 535                 540                 


Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Lys Lys Tyr Thr Ser Trp 
545                 550                 555                 560 


Tyr Gln Gln Lys Pro Gly Gln Ser Pro Leu Leu Val Ile Tyr Gln Asp 
                565                 570                 575     


Thr Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
            580                 585                 590         


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu 
        595                 600                 605             


Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Ser Thr Thr His Val Ile Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
625                 630                 635                 640 


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
                645                 650                 655     


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
            660                 665                 670         


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
        675                 680                 685             


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
    690                 695                 700                 


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Lys Ser Tyr Ser Cys 
705                 710                 715                 720 


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
                725                 730                 735     


Glu Cys Ser 
            


<210>  74
<211>  2229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DVSF-3 WT nucleic acid sequence

<400>  74
ggatccgcca ccatggactg gacatggaga atcctgttcc tggtcgccgc cgcaaccggg       60

acacacgccg aagtgcagct ggtggaatca gggggagggc tggtgcagcc tggaagaagt      120

ctgaggctgt catgcgccgc tagcggcttc acctttgacg attacgccat gttctgggtg      180

aggcaggctc caggcaaggg actggaatgg atcagcggca tttcctggaa ctctgcaact      240

atcgggtatg ccgactccgt gaaaggacgg tttaccattt caagagacaa cgccaagaaa      300

agcctggatc tgcagatgaa ttccctgcgg cccgacgata ccgctctgta ctattgcgca      360

aagggaggac ctagaggcct gcagctgctg agctcctggg tggactactg gggacagggc      420

actctggtca ccgtgtctag tgcttccaca aagggacctt ctgtgttccc actggcaccc      480

tcaagcaaat caacaagcgg aggaactgca gcactgggat gtctggtgaa ggattatttc      540

cccgagcctg tcaccgtgag ttggaactca ggagcactga cttccggagt ccacaccttt      600

ccagcagtgc tgcagtcctc tggactgtac agcctgagtt cagtggtcac agtgcctagc      660

tcctctctgg gcacacagac ttatatctgc aacgtgaatc acaagcctag caatactaaa      720

gtcgacaaga aagtggaacc aaagtcctgt gataaaaccc atacatgccc accttgtcca      780

gcaccagagc tgctgggggg accaagcgtg ttcctgtttc cacccaagcc caaagacaca      840

ctgatgattt ctcggacccc tgaagtcaca tgtgtggtcg tggacgtgag ccacgaggac      900

cccgaagtca agttcaactg gtacgtggat ggcgtcgagg tgcataatgc taagaccaaa      960

ccccgagagg aacagtacaa cagcacttat cgggtcgtgt ccgtcctgac cgtgctgcac     1020

caggactggc tgaacgggaa ggagtataag tgcaaagtgt ccaataaggc cctgcctgct     1080

ccaatcgaga aaacaatttc taaggcaaaa ggacagcctc gcgaaccaca ggtgtacact     1140

ctgcctccat cccgagacga gctgaccaag aaccaggtct ctctgacatg tctggtgaaa     1200

ggcttctatc caagtgatat cgctgtggag tgggaaagca atgggcagcc cgaaaacaat     1260

tacaagacca caccccctgt gctggacagc gatggctcct tctttctgta ttctaagctg     1320

accgtggata aaagtagatg gcagcagggg aacgtctttt cctgctctgt gatgcatgag     1380

gccctgcaca atcattacac acagaagagt ctgtcactga gcccagggaa gcgaggacgg     1440

aaacggagat ccgggtctgg agcaaccaac ttctccctgc tgaaacaggc aggcgacgtg     1500

gaggaaaatc caggacctat ggtcctgcag acccaggtgt ttatctctct gctgctgtgg     1560

attagtggcg cctacgggga tatccagatg acacagtccc ccagttcact gagtgcctca     1620

gtcggcgaca gggtgactat cacctgtcgc gctagccagg atattaggcg ctacctgaac     1680

tggtatcagc agcgaccagg acgagtgcct cagctgctga tctacactac ctccaccctg     1740

cagtctggag tcccaagtag gttcagcggc tccgggtctg tgacagactt tacactgact     1800

attagctccc tgcagcccga agatttcggc acttactatt gccagcagag ttattcacca     1860

ccccacacat ttggacaggg cactaagctg gaaatcaaaa ctgtcgctgc accctcagtg     1920

ttcatttttc ctccatctga cgagcagctg aagtcaggca ccgccagcgt cgtgtgtctg     1980

ctgaacaatt tctaccctcg cgaggctaag gtccagtgga aagtggataa cgcactgcag     2040

tctgggaata gtcaggagtc agtgacagaa caggacagca aggattccac ttattctctg     2100

tctagtaccc tgacactgag caaagccgac tacgagaagc acaaagtcta tgcttgcgaa     2160

gtgacccatc aggggctgag aagtcccgtg acaaagagct tcaacagggg agagtgttga     2220

taactcgag                                                             2229


<210>  75
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DVSF-3 WT amino acid sequence

<400>  75

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Gly Ile Ser Trp Asn Ser Ala Thr Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys 
                85                  90                  95      


Ser Leu Asp Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Gly Pro Arg Gly Leu Gln Leu Leu Ser Ser 
        115                 120                 125             


Trp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln 
        515                 520                 525             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    530                 535                 540                 


Cys Arg Ala Ser Gln Asp Ile Arg Arg Tyr Leu Asn Trp Tyr Gln Gln 
545                 550                 555                 560 


Arg Pro Gly Arg Val Pro Gln Leu Leu Ile Tyr Thr Thr Ser Thr Leu 
                565                 570                 575     


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Val Thr Asp 
            580                 585                 590         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr 
        595                 600                 605             


Tyr Cys Gln Gln Ser Tyr Ser Pro Pro His Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Leu Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
625                 630                 635                 640 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                645                 650                 655     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            660                 665                 670         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        675                 680                 685             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    690                 695                 700                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
705                 710                 715                 720 


Gly Leu Arg Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735 


<210>  76
<211>  2229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DVSF-3 LALA nucleic acid sequence

<400>  76
ggatccgcca ccatggactg gacttggaga atcctgtttc tggtcgccgc cgcaactgga       60

acccacgccg aggtgcagct ggtcgaatca gggggaggcc tggtgcagcc tgggagaagt      120

ctgcggctgt catgcgccgc tagcggcttc acctttgacg attacgcaat gttctgggtg      180

aggcaggcac caggcaaggg actggaatgg atcagcggca tttcctggaa ctctgctacc      240

atcggatatg cagacagcgt gaaagggagg tttacaattt ctagagacaa cgccaagaaa      300

agtctggatc tgcagatgaa ttcactgcgc cccgacgata ccgccctgta ctattgcgct      360

aagggcggac ccaggggcct gcagctgctg agctcctggg tggactactg ggggcagggc      420

actctggtca ccgtgtctag tgcctccaca aagggcccta gcgtgttccc actggctccc      480

tcaagcaaat caacaagcgg gggcactgca gccctgggat gtctggtgaa ggattatttc      540

cccgagcctg tcaccgtgag ttggaactca ggggctctga ctagcggcgt ccacaccttt      600

cccgcagtgc tgcagtcctc tggcctgtac agcctgagtt cagtggtcac tgtccctagc      660

tcctctctgg gaacacagac ttatatctgc aacgtgaatc acaagccttc caataccaaa      720

gtcgacaaga aagtggaacc aaagtcttgt gataaaaccc atacatgccc tccctgtcca      780

gcaccagagg ctgcaggagg gccaagcgtg ttcctgtttc cacccaagcc caaagacaca      840

ctgatgatta gccggacccc tgaagtcaca tgcgtggtcg tggacgtgag ccacgaggac      900

cccgaagtca agtttaactg gtacgtggat ggcgtcgagg tgcataatgc taagaccaaa      960

ccccgagagg aacagtacaa cagtacttat agggtcgtgt cagtcctgac cgtgctgcac     1020

caggactggc tgaacgggaa ggagtataag tgcaaagtgt ccaataaggc actgcctgcc     1080

ccaatcgaga aaactatttc taaggctaaa ggccagccta gagaaccaca ggtgtacacc     1140

ctgcctccaa gccgggacga gctgaccaag aaccaggtca gcctgacatg tctggtgaaa     1200

ggattctatc catccgatat cgcagtggag tgggaatcta atgggcagcc cgaaaacaat     1260

tacaagacca caccccctgt gctggacagc gatggcagct tcttcctgta tagcaagctg     1320

accgtggata aatcccgctg gcagcagggg aacgtctttt cctgctctgt gatgcatgag     1380

gccctgcaca atcattacac acagaagagt ctgtcactga gcccaggaaa gcgagggagg     1440

aaaaggagat ccggatctgg ggctactaac ttctccctgc tgaagcaggc aggcgacgtg     1500

gaggaaaatc ccggacctat ggtcctgcag acacaggtgt ttatcagcct gctgctgtgg     1560

atttccggcg cttacggaga tatccagatg actcagtccc ccagttcact gagtgcatca     1620

gtcggcgacc gggtgactat cacctgtcgc gcctctcagg atattcggcg ctacctgaat     1680

tggtatcagc agcgaccagg acgagtgcct cagctgctga tctacactac ctccacactg     1740

cagtctggcg tcccaagtag gttcagcggc tccggatctg tgactgactt tacactgact     1800

attagctccc tgcagcccga ggatttcggc acctactatt gccagcagag ttattcacca     1860

ccccacacat ttgggcaggg cactaagctg gaaatcaaaa ccgtcgccgc tcccagcgtg     1920

ttcatctttc ctccaagtga cgagcagctg aagtcaggaa cagccagcgt ggtgtgcctg     1980

ctgaacaatt tctaccctag agaagccaag gtccagtgga aagtggataa cgctctgcag     2040

tctgggaata gtcaggagtc agtgacagaa caggacagca aggattccac ttattctctg     2100

tctagtaccc tgacactgag caaagcagac tacgagaagc ataaagtgta tgcctgcgaa     2160

gtcacccacc aggggctgcg gtcaccagtc acaaaatcct ttaacagagg cgaatgctga     2220

taactcgag                                                             2229


<210>  77
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DSVF-3 LALA amino acid sequence

<400>  77

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Gly Ile Ser Trp Asn Ser Ala Thr Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys 
                85                  90                  95      


Ser Leu Asp Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Gly Pro Arg Gly Leu Gln Leu Leu Ser Ser 
        115                 120                 125             


Trp Val Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln 
        515                 520                 525             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    530                 535                 540                 


Cys Arg Ala Ser Gln Asp Ile Arg Arg Tyr Leu Asn Trp Tyr Gln Gln 
545                 550                 555                 560 


Arg Pro Gly Arg Val Pro Gln Leu Leu Ile Tyr Thr Thr Ser Thr Leu 
                565                 570                 575     


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Val Thr Asp 
            580                 585                 590         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Gly Thr Tyr 
        595                 600                 605             


Tyr Cys Gln Gln Ser Tyr Ser Pro Pro His Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Leu Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
625                 630                 635                 640 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                645                 650                 655     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            660                 665                 670         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        675                 680                 685             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    690                 695                 700                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
705                 710                 715                 720 


Gly Leu Arg Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735 


<210>  78
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-PSMA nucleic acid sequence

<400>  78
ggatccgcca ccatggattg gacatggagg attctgtttc tggtcgccgc cgccacagga       60

acccacgccg aagtgcagct ggtgcagtca ggagccgagg tgaagaaacc aggcgaaagt      120

ctgaaaatct catgcaaagg aagtgggtac tcattcacta gcaactggat tggatgggtg      180

cggcagatgc caggcaaggg actggagtgg atgggaatca tctaccccgg ggactccgat      240

acacgctata gtccttcatt tcagggccag gtgacaatct ctgccgacaa aagcatttcc      300

actgcttatc tgcagtggag ctccctgaag gcttccgata ccgcaatgta ctattgcgcc      360

aggcagacag gcttcctgtg gtctagtgac ctgtggggga gaggcaccct ggtcacagtg      420

tcaagcgcct ctaccaaagg accaagcgtg ttcccactgg ctccttcctc taagtctact      480

agtggcggaa ccgccgctct gggatgtctg gtgaaggatt acttccctga gccagtcaca      540

gtgtcctgga actctggcgc tctgaccagc ggagtccaca catttcccgc agtgctgcag      600

agttcaggcc tgtactccct gagctccgtg gtcacagtcc cttctagttc actgggaact      660

cagacctata tctgcaacgt gaatcacaaa ccttccaata ctaaggtcga caagaaagtg      720

gaaccaaaat cttgtgataa gacacatact tgccctccct gtccagcacc tgagctgctg      780

ggcggcccaa gcgtgttcct gtttccaccc aagcccaaag ataccctgat gattagcagg      840

acaccagaag tcacttgcgt ggtcgtggac gtgtcccacg aggaccccga agtcaagttc      900

aactggtacg tggacggcgt cgaggtgcat aatgctaaga ccaaaccaag agaggaacag      960

tacaactcaa cctatcgggt cgtgagcgtc ctgacagtgc tgcaccagga ctggctgaac     1020

ggaaaggagt ataagtgcaa agtgtctaac aaggccctgc cagctcccat cgagaagact     1080

attagcaagg ctaaagggca gccacgcgaa ccccaggtgt acaccctgcc tccatcacga     1140

gatgagctga caaaaaacca ggtctctctg acttgtctgg tgaagggatt ctatccctct     1200

gacatcgcag tggagtggga aagtaatggg cagcctgaaa acaattacaa gaccacaccc     1260

cctgtgctgg acagtgatgg atcattcttt ctgtatagta aactgaccgt ggataagtca     1320

agatggcagc aggggaacgt cttttcatgc agcgtgatgc atgaggccct gcacaatcat     1380

tacacccaga agtccctgtc tctgagtcct ggcaaacggg gacgcaagag gagatcagga     1440

agcggggcta caaacttctc cctgctgaag caggcagggg acgtggagga aaatcctggc     1500

ccaatggtcc tgcagaccca ggtgtttatc tccctgctgc tgtggatttc tggggcatac     1560

ggcgccatcc agctgacaca gtctcccagc tccctgtccg catctgtcgg cgaccgagtg     1620

accatcacat gtagggccag ccaggatatt tctagtgctc tggcatggta ccagcagaag     1680

cctgggaaag caccaaagct gctgatctat gatgcctcaa gcctggaatc cggagtgcct     1740

agccggttct ccggatacgg aagtgggaca gactttactc tgaccattaa cagcctgcag     1800

cctgaggatt tcgccactta ctattgccag cagttcaata gctatccact gacttttgga     1860

gggggcacca aagtggaaat caagcgaact gtcgcagccc ctagcgtgtt catttttcca     1920

ccctccgatg agcagctgaa gagcggcacc gcttccgtgg tgtgcctgct gaacaacttc     1980

tacccacgcg aggccaaagt ccagtggaag gtggacaacg ctctgcagtc tggaaatagt     2040

caggagtcag tgactgaaca ggacagcaaa gattccacct attctctgtc ctctacactg     2100

actctgagca aggcagacta cgagaagcat aaagtgtatg cctgcgaagt cacccaccag     2160

gggctgtcct caccagtcac taaatctttc aatcggggag aatgttgata actcgag        2217


<210>  79
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-PSMA amino acid sequence

<400>  79

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ser Asn Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser 
65                  70                  75                  80  


Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Thr Gly Phe Leu Trp Ser Ser Asp Leu Trp 
        115                 120                 125             


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
465                 470                 475                 480 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
            500                 505                 510         


Ser Gly Ala Tyr Gly Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
        515                 520                 525             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    530                 535                 540                 


Asp Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
545                 550                 555                 560 


Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro 
                565                 570                 575     


Ser Arg Phe Ser Gly Tyr Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            580                 585                 590         


Asn Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe 
        595                 600                 605             


Asn Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  80
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV-snapi amino acid sequence

<400>  80

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Lys Pro 
            20                  25                  30          


Gly Ala Ser Ala Met Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        35                  40                  45              


Ser Tyr Trp Ile Thr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Asp Ile Tyr Pro Gly Thr Gly Arg Thr Ile Tyr Lys Glu 
65                  70                  75                  80  


Lys Phe Lys Thr Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr 
                85                  90                  95      


Ala Phe Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Tyr Gly Ser Pro Tyr Tyr Ala Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
465                 470                 475                 480 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg 
            500                 505                 510         


Val His Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val 
        515                 520                 525             


Ser Gln Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val 
    530                 535                 540                 


Asp Tyr Asp Gly Asp Ser Tyr Val Asn Trp Tyr Gln Gln Lys Pro Gly 
545                 550                 555                 560 


Gln Ser Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Ser Gly 
                565                 570                 575     


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
            580                 585                 590         


Asn Ile His Pro Val Glu Glu Glu Asp Val Ala Thr Tyr Tyr Cys Gln 
        595                 600                 605             


Glu Ser Asn Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
    610                 615                 620                 


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
625                 630                 635                 640 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
                645                 650                 655     


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
            660                 665                 670         


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
        675                 680                 685             


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
    690                 695                 700                 


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
705                 710                 715                 720 


Arg Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730             


<210>  81
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV E1 consensus

<400>  81

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Tyr Glu His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro 
            20                  25                  30          


Tyr Lys Thr Leu Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu 
        35                  40                  45              


Met Glu Leu Leu Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr 
    50                  55                  60                  


Ile Thr Cys Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys 
65                  70                  75                  80  


Cys Gly Thr Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys 
                85                  90                  95      


Lys Val Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys 
            100                 105                 110         


Phe Cys Asp Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys 
        115                 120                 125             


Ser Glu Ser Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr 
    130                 135                 140                 


Ala Ser Ala Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile 
145                 150                 155                 160 


Thr Val Thr Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp 
                165                 170                 175     


Ala Lys Phe Ile Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp 
            180                 185                 190         


Asn Lys Ile Val Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro 
        195                 200                 205             


Pro Phe Gly Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg 
    210                 215                 220                 


Thr Pro Glu Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln 
225                 230                 235                 240 


Arg Pro Ala Val Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser 
                245                 250                 255     


Gly Phe Lys Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr 
            260                 265                 270         


Ala Pro Phe Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn 
        275                 280                 285             


Cys Ala Val Gly Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala 
    290                 295                 300                 


Phe Thr Arg Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu 
305                 310                 315                 320 


Val Pro Ala Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile 
                325                 330                 335     


Lys Tyr Ala Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr 
            340                 345                 350         


Asn Ala Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser 
        355                 360                 365             


Gln Leu Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg 
    370                 375                 380                 


Val Gln Val Cys Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro 
385                 390                 395                 400 


Pro Lys Asp His Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly 
                405                 410                 415     


Val Gln Asp Ile Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr 
            420                 425                 430         


Gly Gly Val Gly Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val 
        435                 440                 445             


Val Leu Cys Val Ser Phe Ser Arg His 
    450                 455         


<210>  82
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV E2 consensus

<400>  82

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro 
            20                  25                  30          


Tyr Leu Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser 
        35                  40                  45              


Pro Val Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu 
    50                  55                  60                  


Lys Ile Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His 
65                  70                  75                  80  


Asp Trp Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala 
                85                  90                  95      


Glu Arg Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr 
            100                 105                 110         


Gly Thr Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr 
        115                 120                 125             


Leu Thr Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr 
    130                 135                 140                 


His Pro Phe His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His 
145                 150                 155                 160 


Ser Arg Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln 
                165                 170                 175     


Ser Thr Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp 
            180                 185                 190         


Thr Pro Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile 
        195                 200                 205             


Thr Val Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser 
    210                 215                 220                 


Asn Glu Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val 
225                 230                 235                 240 


Asp Gln Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn 
                245                 250                 255     


Ser Pro Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys 
            260                 265                 270         


Ile His Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys 
        275                 280                 285             


Ala Arg Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu 
    290                 295                 300                 


Leu Tyr Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu 
305                 310                 315                 320 


Glu Pro Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val 
                325                 330                 335     


Leu Thr Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu 
            340                 345                 350         


Pro Tyr Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly 
        355                 360                 365             


His Pro His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met 
    370                 375                 380                 


Thr Val Val Val Val Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val 
385                 390                 395                 400 


Gly Met Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr 
                405                 410                 415     


Pro Tyr Glu Leu Thr Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu 
            420                 425                 430         


Ile Cys Cys Ile Arg Thr Ala Lys Ala 
        435                 440     


<210>  83
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV capsid consensus

<400>  83

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Met Glu Phe Ile Pro Thr Gln Thr Phe Tyr Asn Arg Arg Tyr 
            20                  25                  30          


Gln Pro Arg Pro Trp Thr Pro Arg Pro Thr Ile Gln Val Ile Arg Pro 
        35                  40                  45              


Arg Pro Arg Pro Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile Ser 
    50                  55                  60                  


Ala Val Asn Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys Pro Arg 
65                  70                  75                  80  


Arg Asn Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln 
                85                  90                  95      


Asn Asn Thr Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln 
            100                 105                 110         


Lys Lys Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu 
        115                 120                 125             


Asn Asp Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr 
    130                 135                 140                 


Ala Cys Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly 
145                 150                 155                 160 


Thr Ile Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg Ser Ser 
                165                 170                 175     


Lys Tyr Asp Leu Glu Cys Ala Gln Ile Pro Val His Met Lys Ser Asp 
            180                 185                 190         


Ala Ser Lys Phe Thr His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His 
        195                 200                 205             


His Gly Ala Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly 
    210                 215                 220                 


Ala Gly Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly 
225                 230                 235                 240 


Arg Val Val Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr 
                245                 250                 255     


Ala Leu Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr 
            260                 265                 270         


Pro Glu Gly Ala Glu Glu Trp 
        275                 


<210>  84
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV E1 consensus

<400>  84

Tyr Glu His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys 
1               5                   10                  15      


Thr Leu Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu 
            20                  25                  30          


Leu Leu Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr 
        35                  40                  45              


Cys Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly 
    50                  55                  60                  


Thr Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val 
65                  70                  75                  80  


Phe Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys 
                85                  90                  95      


Asp Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu 
            100                 105                 110         


Ser Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser 
        115                 120                 125             


Ala Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val 
    130                 135                 140                 


Thr Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys 
145                 150                 155                 160 


Phe Ile Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys 
                165                 170                 175     


Ile Val Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe 
            180                 185                 190         


Gly Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro 
        195                 200                 205             


Glu Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro 
    210                 215                 220                 


Ala Val Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe 
225                 230                 235                 240 


Lys Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro 
                245                 250                 255     


Phe Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala 
            260                 265                 270         


Val Gly Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr 
        275                 280                 285             


Arg Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro 
    290                 295                 300                 


Ala Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr 
305                 310                 315                 320 


Ala Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala 
                325                 330                 335     


Val Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu 
            340                 345                 350         


Gln Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln 
        355                 360                 365             


Val Cys Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys 
    370                 375                 380                 


Asp His Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln 
385                 390                 395                 400 


Asp Ile Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly 
                405                 410                 415     


Val Gly Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu 
            420                 425                 430         


Cys Val Ser Phe Ser Arg His 
        435                 


<210>  85
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV E2 consensus

<400>  85

Ser Thr Lys Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu 
1               5                   10                  15      


Ala His Cys Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val 
            20                  25                  30          


Ala Leu Glu Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile 
        35                  40                  45              


Gln Val Ser Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp 
    50                  55                  60                  


Thr Lys Leu Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg 
65                  70                  75                  80  


Ala Gly Leu Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr 
                85                  90                  95      


Met Gly His Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr 
            100                 105                 110         


Val Gly Phe Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro 
        115                 120                 125             


Phe His His Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg 
    130                 135                 140                 


Pro Gln His Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr 
145                 150                 155                 160 


Ala Ala Thr Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro 
                165                 170                 175     


Asp Arg Thr Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val 
            180                 185                 190         


Asn Gly Gln Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu 
        195                 200                 205             


Gly Leu Thr Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln 
    210                 215                 220                 


Cys His Ala Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro 
225                 230                 235                 240 


Leu Val Pro Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His 
                245                 250                 255     


Ile Pro Phe Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg 
            260                 265                 270         


Asn Pro Thr Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr 
        275                 280                 285             


Pro Asp His Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro 
    290                 295                 300                 


Asn Tyr Gln Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr 
305                 310                 315                 320 


Val Pro Thr Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr 
                325                 330                 335     


Lys Tyr Trp Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro 
            340                 345                 350         


His Glu Ile Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val 
        355                 360                 365             


Val Val Val Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met 
    370                 375                 380                 


Ala Ala Gly Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr 
385                 390                 395                 400 


Glu Leu Thr Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys 
                405                 410                 415     


Cys Ile Arg Thr Ala Lys Ala 
            420             


<210>  86
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV capsid consensus

<400>  86

Met Glu Phe Ile Pro Thr Gln Thr Phe Tyr Asn Arg Arg Tyr Gln Pro 
1               5                   10                  15      


Arg Pro Trp Thr Pro Arg Pro Thr Ile Gln Val Ile Arg Pro Arg Pro 
            20                  25                  30          


Arg Pro Gln Arg Gln Ala Gly Gln Leu Ala Gln Leu Ile Ser Ala Val 
        35                  40                  45              


Asn Lys Leu Thr Met Arg Ala Val Pro Gln Gln Lys Pro Arg Arg Asn 
    50                  55                  60                  


Arg Lys Asn Lys Lys Gln Lys Gln Lys Gln Gln Ala Pro Gln Asn Asn 
65                  70                  75                  80  


Thr Asn Gln Lys Lys Gln Pro Pro Lys Lys Lys Pro Ala Gln Lys Lys 
                85                  90                  95      


Lys Lys Pro Gly Arg Arg Glu Arg Met Cys Met Lys Ile Glu Asn Asp 
            100                 105                 110         


Cys Ile Phe Glu Val Lys His Glu Gly Lys Val Thr Gly Tyr Ala Cys 
        115                 120                 125             


Leu Val Gly Asp Lys Val Met Lys Pro Ala His Val Lys Gly Thr Ile 
    130                 135                 140                 


Asp Asn Ala Asp Leu Ala Lys Leu Ala Phe Lys Arg Ser Ser Lys Tyr 
145                 150                 155                 160 


Asp Leu Glu Cys Ala Gln Ile Pro Val His Met Lys Ser Asp Ala Ser 
                165                 170                 175     


Lys Phe Thr His Glu Lys Pro Glu Gly Tyr Tyr Asn Trp His His Gly 
            180                 185                 190         


Ala Val Gln Tyr Ser Gly Gly Arg Phe Thr Ile Pro Thr Gly Ala Gly 
        195                 200                 205             


Lys Pro Gly Asp Ser Gly Arg Pro Ile Phe Asp Asn Lys Gly Arg Val 
    210                 215                 220                 


Val Ala Ile Val Leu Gly Gly Ala Asn Glu Gly Ala Arg Thr Ala Leu 
225                 230                 235                 240 


Ser Val Val Thr Trp Asn Lys Asp Ile Val Thr Lys Ile Thr Pro Glu 
                245                 250                 255     


Gly Ala Glu Glu Trp 
            260     


<210>  87
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV Env consensus

<400>  87

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr 
            20                  25                  30          


Phe Pro Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu 
        35                  40                  45              


Pro Glu Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly 
    50                  55                  60                  


Tyr Tyr Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln 
65                  70                  75                  80  


Arg Arg Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp Thr Trp 
                85                  90                  95      


Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Ser Thr Lys 
            100                 105                 110         


Asp Asn Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys 
        115                 120                 125             


Pro Asp Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu 
    130                 135                 140                 


Arg Ile Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser 
145                 150                 155                 160 


Leu Gln Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu 
                165                 170                 175     


Arg Tyr Met Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu 
            180                 185                 190         


Phe Val Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His 
        195                 200                 205             


Phe Ile Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe 
    210                 215                 220                 


Thr Asp Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His 
225                 230                 235                 240 


Asp Pro Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His 
                245                 250                 255     


Gly Lys Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr 
            260                 265                 270         


Thr Glu Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr 
        275                 280                 285             


Leu Met Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln 
    290                 295                 300                 


Thr Val Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr 
305                 310                 315                 320 


Thr Thr Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala 
                325                 330                 335     


Ala Val Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro 
            340                 345                 350         


Arg Asn Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe 
        355                 360                 365             


Pro Leu Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr 
    370                 375                 380                 


Val Thr Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His 
385                 390                 395                 400 


Pro Thr Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln 
                405                 410                 415     


Glu Glu Trp Val Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr 
            420                 425                 430         


Glu Gly Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp 
        435                 440                 445             


Pro Gln Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile 
    450                 455                 460                 


Ile Leu Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val 
465                 470                 475                 480 


Ser Val Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly 
                485                 490                 495     


Met Cys Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr 
            500                 505                 510         


Pro Gly Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg 
        515                 520                 525             


Thr Ala Lys Ala Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp 
    530                 535                 540                 


Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Tyr 
545                 550                 555                 560 


Glu His Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr 
                565                 570                 575     


Leu Val Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu 
            580                 585                 590         


Leu Ser Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys 
        595                 600                 605             


Glu Tyr Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr 
    610                 615                 620                 


Ala Glu Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe 
625                 630                 635                 640 


Thr Gly Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp 
                645                 650                 655     


Ala Glu Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser 
            660                 665                 670         


Cys Lys Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala 
        675                 680                 685             


Ser Ala Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr 
    690                 695                 700                 


Ala Tyr Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe 
705                 710                 715                 720 


Ile Val Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile 
                725                 730                 735     


Val Val Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly 
            740                 745                 750         


Ala Gly Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu 
        755                 760                 765             


Ser Lys Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala 
    770                 775                 780                 


Val Gly Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys 
785                 790                 795                 800 


Tyr Trp Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe 
                805                 810                 815     


Gly Cys Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val 
            820                 825                 830         


Gly Asn Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg 
        835                 840                 845             


Val Val Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala 
    850                 855                 860                 


Cys Thr His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala 
865                 870                 875                 880 


Ala Ser Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val 
                885                 890                 895     


Thr Ile Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln 
            900                 905                 910         


Ile Ser Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val 
        915                 920                 925             


Cys Ser Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp 
    930                 935                 940                 


His Ile Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp 
945                 950                 955                 960 


Ile Ser Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly Val 
                965                 970                 975     


Gly Leu Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu Cys 
            980                 985                 990         


Val Ser Phe Ser Arg His 
        995             


<210>  88
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIKV Env consensus

<400>  88

Ser Leu Ala Ile Pro Val Met Cys Leu Leu Ala Asn Thr Thr Phe Pro 
1               5                   10                  15      


Cys Ser Gln Pro Pro Cys Thr Pro Cys Cys Tyr Glu Lys Glu Pro Glu 
            20                  25                  30          


Glu Thr Leu Arg Met Leu Glu Asp Asn Val Met Arg Pro Gly Tyr Tyr 
        35                  40                  45              


Gln Leu Leu Gln Ala Ser Leu Thr Cys Ser Pro His Arg Gln Arg Arg 
    50                  55                  60                  


Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp Thr Trp Ile Leu 
65                  70                  75                  80  


Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Ser Thr Lys Asp Asn 
                85                  90                  95      


Phe Asn Val Tyr Lys Ala Thr Arg Pro Tyr Leu Ala His Cys Pro Asp 
            100                 105                 110         


Cys Gly Glu Gly His Ser Cys His Ser Pro Val Ala Leu Glu Arg Ile 
        115                 120                 125             


Arg Asn Glu Ala Thr Asp Gly Thr Leu Lys Ile Gln Val Ser Leu Gln 
    130                 135                 140                 


Ile Gly Ile Lys Thr Asp Asp Ser His Asp Trp Thr Lys Leu Arg Tyr 
145                 150                 155                 160 


Met Asp Asn His Met Pro Ala Asp Ala Glu Arg Ala Gly Leu Phe Val 
                165                 170                 175     


Arg Thr Ser Ala Pro Cys Thr Ile Thr Gly Thr Met Gly His Phe Ile 
            180                 185                 190         


Leu Ala Arg Cys Pro Lys Gly Glu Thr Leu Thr Val Gly Phe Thr Asp 
        195                 200                 205             


Ser Arg Lys Ile Ser His Ser Cys Thr His Pro Phe His His Asp Pro 
    210                 215                 220                 


Pro Val Ile Gly Arg Glu Lys Phe His Ser Arg Pro Gln His Gly Lys 
225                 230                 235                 240 


Glu Leu Pro Cys Ser Thr Tyr Val Gln Ser Thr Ala Ala Thr Thr Glu 
                245                 250                 255     


Glu Ile Glu Val His Met Pro Pro Asp Thr Pro Asp Arg Thr Leu Met 
            260                 265                 270         


Ser Gln Gln Ser Gly Asn Val Lys Ile Thr Val Asn Gly Gln Thr Val 
        275                 280                 285             


Arg Tyr Lys Cys Asn Cys Gly Gly Ser Asn Glu Gly Leu Thr Thr Thr 
    290                 295                 300                 


Asp Lys Val Ile Asn Asn Cys Lys Val Asp Gln Cys His Ala Ala Val 
305                 310                 315                 320 


Thr Asn His Lys Lys Trp Gln Tyr Asn Ser Pro Leu Val Pro Arg Asn 
                325                 330                 335     


Ala Glu Leu Gly Asp Arg Lys Gly Lys Ile His Ile Pro Phe Pro Leu 
            340                 345                 350         


Ala Asn Val Thr Cys Arg Val Pro Lys Ala Arg Asn Pro Thr Val Thr 
        355                 360                 365             


Tyr Gly Lys Asn Gln Val Ile Met Leu Leu Tyr Pro Asp His Pro Thr 
    370                 375                 380                 


Leu Leu Ser Tyr Arg Asn Met Gly Glu Glu Pro Asn Tyr Gln Glu Glu 
385                 390                 395                 400 


Trp Val Met His Lys Lys Glu Val Val Leu Thr Val Pro Thr Glu Gly 
                405                 410                 415     


Leu Glu Val Thr Trp Gly Asn Asn Glu Pro Tyr Lys Tyr Trp Pro Gln 
            420                 425                 430         


Leu Ser Thr Asn Gly Thr Ala His Gly His Pro His Glu Ile Ile Leu 
        435                 440                 445             


Tyr Tyr Tyr Glu Leu Tyr Pro Thr Met Thr Val Val Val Val Ser Val 
    450                 455                 460                 


Ala Thr Phe Ile Leu Leu Ser Met Val Gly Met Ala Ala Gly Met Cys 
465                 470                 475                 480 


Met Cys Ala Arg Arg Arg Cys Ile Thr Pro Tyr Glu Leu Thr Pro Gly 
                485                 490                 495     


Ala Thr Val Pro Phe Leu Leu Ser Leu Ile Cys Cys Ile Arg Thr Ala 
            500                 505                 510         


Lys Ala Arg Gly Arg Lys Arg Arg Ser Ala Thr Met Asp Trp Thr Trp 
        515                 520                 525             


Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val His Ser Tyr Glu His 
    530                 535                 540                 


Val Thr Val Ile Pro Asn Thr Val Gly Val Pro Tyr Lys Thr Leu Val 
545                 550                 555                 560 


Asn Arg Pro Gly Tyr Ser Pro Met Val Leu Glu Met Glu Leu Leu Ser 
                565                 570                 575     


Val Thr Leu Glu Pro Thr Leu Ser Leu Asp Tyr Ile Thr Cys Glu Tyr 
            580                 585                 590         


Lys Thr Val Ile Pro Ser Pro Tyr Val Lys Cys Cys Gly Thr Ala Glu 
        595                 600                 605             


Cys Lys Asp Lys Asn Leu Pro Asp Tyr Ser Cys Lys Val Phe Thr Gly 
    610                 615                 620                 


Val Tyr Pro Phe Met Trp Gly Gly Ala Tyr Cys Phe Cys Asp Ala Glu 
625                 630                 635                 640 


Asn Thr Gln Leu Ser Glu Ala His Val Glu Lys Ser Glu Ser Cys Lys 
                645                 650                 655     


Thr Glu Phe Ala Ser Ala Tyr Arg Ala His Thr Ala Ser Ala Ser Ala 
            660                 665                 670         


Lys Leu Arg Val Leu Tyr Gln Gly Asn Asn Ile Thr Val Thr Ala Tyr 
        675                 680                 685             


Ala Asn Gly Asp His Ala Val Thr Val Lys Asp Ala Lys Phe Ile Val 
    690                 695                 700                 


Gly Pro Met Ser Ser Ala Trp Thr Pro Phe Asp Asn Lys Ile Val Val 
705                 710                 715                 720 


Tyr Lys Gly Asp Val Tyr Asn Met Asp Tyr Pro Pro Phe Gly Ala Gly 
                725                 730                 735     


Arg Pro Gly Gln Phe Gly Asp Ile Gln Ser Arg Thr Pro Glu Ser Lys 
            740                 745                 750         


Asp Val Tyr Ala Asn Thr Gln Leu Val Leu Gln Arg Pro Ala Val Gly 
        755                 760                 765             


Thr Val His Val Pro Tyr Ser Gln Ala Pro Ser Gly Phe Lys Tyr Trp 
    770                 775                 780                 


Leu Lys Glu Arg Gly Ala Ser Leu Gln His Thr Ala Pro Phe Gly Cys 
785                 790                 795                 800 


Gln Ile Ala Thr Asn Pro Val Arg Ala Val Asn Cys Ala Val Gly Asn 
                805                 810                 815     


Met Pro Ile Ser Ile Asp Ile Pro Glu Ala Ala Phe Thr Arg Val Val 
            820                 825                 830         


Asp Ala Pro Ser Leu Thr Asp Met Ser Cys Glu Val Pro Ala Cys Thr 
        835                 840                 845             


His Ser Ser Asp Phe Gly Gly Val Ala Ile Ile Lys Tyr Ala Ala Ser 
    850                 855                 860                 


Lys Lys Gly Lys Cys Ala Val His Ser Met Thr Asn Ala Val Thr Ile 
865                 870                 875                 880 


Arg Glu Ala Glu Ile Glu Val Glu Gly Asn Ser Gln Leu Gln Ile Ser 
                885                 890                 895     


Phe Ser Thr Ala Leu Ala Ser Ala Glu Phe Arg Val Gln Val Cys Ser 
            900                 905                 910         


Thr Gln Val His Cys Ala Ala Glu Cys His Pro Pro Lys Asp His Ile 
        915                 920                 925             


Val Asn Tyr Pro Ala Ser His Thr Thr Leu Gly Val Gln Asp Ile Ser 
    930                 935                 940                 


Ala Thr Ala Met Ser Trp Val Gln Lys Ile Thr Gly Gly Val Gly Leu 
945                 950                 955                 960 


Val Val Ala Val Ala Ala Leu Ile Leu Ile Val Val Leu Cys Val Ser 
                965                 970                 975     


Phe Ser Arg His 
            980 


<210>  89
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV E1 consensus

<400>  89
atggactgga cctggatcct gtttctggtc gctgctgcca cccgggtgca cagctacgag       60

cacgtgaccg tgatccccaa caccgtgggc gtgccctaca agaccctggt gaacaggccc      120

ggctacagcc ccatggtgct ggaaatggaa ctgctgtccg tgaccctgga acccaccctg      180

agcctggact acatcacctg cgagtacaag acagtgatcc ccagccccta cgtgaagtgc      240

tgcggcaccg ccgagtgcaa ggacaagaac ctgcccgact acagctgcaa ggtgttcacc      300

ggcgtgtacc ccttcatgtg gggcggagcc tactgcttct gcgacgccga gaacacccag      360

ctgtccgagg cccacgtgga gaagagcgag agctgcaaga ccgagttcgc cagcgcctac      420

cgggcccaca cagccagcgc cagcgccaag ctgcgggtgc tgtaccaggg caacaacatc      480

accgtgaccg cctacgccaa cggcgaccac gccgtgacag tgaaggacgc caagttcatc      540

gtgggcccca tgagcagcgc ctggaccccc ttcgacaaca agatcgtggt gtacaagggc      600

gacgtgtaca acatggacta cccccccttc ggagccggca gacccggcca gttcggcgac      660

atccagagcc ggacccccga gagcaaggac gtgtacgcca atacccagct ggtgctgcag      720

agacccgccg tgggcaccgt gcacgtgcct tacagccagg cccccagcgg cttcaagtac      780

tggctgaaag agaggggcgc cagcctgcag cacaccgccc ccttcggctg ccagatcgcc      840

accaaccccg tgcgggccgt gaattgtgcc gtgggcaaca tgcccatcag catcgacatc      900

cccgaggccg ccttcaccag ggtggtggac gcccccagcc tgaccgacat gagctgcgag      960

gtgcccgcct gcacccacag cagcgacttc ggcggcgtgg ccatcatcaa gtacgccgcc     1020

agcaagaaag gcaagtgcgc cgtgcacagc atgaccaatg ccgtgaccat ccgggaggcc     1080

gagatcgagg tggagggcaa cagccagctg cagatcagct tcagcaccgc cctggccagc     1140

gccgagttcc gggtgcaggt ctgcagcacc caggtgcact gtgccgccga gtgtcacccc     1200

cccaaggacc acatcgtgaa ctaccccgcc agccacacca ccctgggcgt gcaggacatc     1260

agcgccaccg ccatgagctg ggtgcagaag atcacaggcg gcgtcggcct ggtggtggcc     1320

gtggccgccc tgatcctgat cgtggtgctg tgcgtgagct tcagccggca ctga           1374


<210>  90
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV E2 consensus

<400>  90
atggactgga cctggatcct gttcctggtc gctgctgcca caagagtgca cagcagcacc       60

aaggacaact tcaacgtgta caaggccacc cggccctacc tggcccactg ccccgattgc      120

ggcgagggcc acagctgcca cagccccgtg gccctggaac ggatccggaa cgaggccacc      180

gacggcaccc tgaagatcca ggtgtccctg cagatcggca tcaagaccga cgacagccac      240

gactggacca agctgcggta catggacaac cacatgcccg ccgacgccga gagagccggc      300

ctgttcgtcc ggaccagcgc cccctgcacc atcaccggca ccatgggcca cttcatcctg      360

gcccggtgcc ccaagggcga gacactgacc gtgggcttca ccgacagccg gaagatcagc      420

cactcctgca cccacccctt ccaccacgac ccccccgtga tcggccggga gaagttccac      480

agcaggcccc agcacggcaa agagctgccc tgcagcacct acgtgcagag caccgccgcc      540

acaaccgagg aaatcgaggt gcacatgccc cccgataccc ccgaccggac cctgatgagc      600

cagcagagcg gcaacgtgaa gatcaccgtg aacggccaga ccgtgcggta caagtgcaac      660

tgcggcggca gcaacgaggg cctgaccacc accgacaagg tgatcaacaa ctgcaaggtg      720

gaccagtgcc acgccgccgt gaccaaccac aagaagtggc agtacaacag ccccctggtg      780

ccccggaatg ccgagctggg cgaccggaag ggcaagatcc acatcccctt ccccctggcc      840

aacgtgacct gccgggtgcc caaggcccgg aaccccaccg tgacctacgg caagaaccag      900

gtgatcatgc tgctgtaccc cgaccacccc accctgctgt cctaccggaa catgggcgag      960

gaacccaact accaagagga gtgggtcatg cacaagaaag aagtggtgct gaccgtcccc     1020

accgagggcc tggaagtgac ctggggcaac aacgagccct acaagtactg gccccagctg     1080

tccaccaacg gcaccgccca cggccacccc cacgagatca tcctgtacta ctacgagctg     1140

taccctacca tgaccgtggt ggtggtgtcc gtggccacct ttatcctgct gtccatggtc     1200

ggcatggccg ctggcatgtg catgtgcgcc aggaggcgct gtatcacccc ctacgagctg     1260

acacctggcg ccaccgtgcc ctttctgctg tccctgatct gctgcatccg gaccgccaag     1320

gcctga                                                                1326


<210>  91
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV capsid consensus

<400>  91
atggactgga cctggatcct gttcctggtg gccgctgcca cccgggtgca cagcatggaa       60

ttcatcccca cccagacctt ctacaaccgg cgctaccagc ccagaccctg gacccccagg      120

cccaccatcc aggtgatccg gcccaggccc agaccccaga ggcaggccgg gcagctggca      180

cagctgatca gcgccgtgaa caagctgacc atgagagccg tgccccagca gaagcccagg      240

cggaaccgga agaacaagaa gcagaagcag aaacagcagg ccccccagaa caacaccaac      300

cagaagaagc agccccccaa gaagaagcct gcccagaaga agaagaaacc cggcaggcgg      360

gagcggatgt gcatgaagat cgagaacgac tgcatcttcg aggtgaagca cgagggcaag      420

gtgaccggct acgcctgcct ggtcggcgac aaagtgatga agcccgccca cgtgaagggc      480

accatcgaca acgccgacct ggccaagctg gccttcaagc ggagcagcaa gtacgacctg      540

gaatgcgccc agatccccgt gcacatgaag agcgacgcca gcaagttcac ccacgagaag      600

cccgagggct actacaactg gcaccacgga gccgtgcagt acagcggcgg caggttcacc      660

atccccacag gcgccggaaa gcccggcgac agcggcaggc ccatcttcga caacaagggc      720

cgggtggtgg ccatcgtgct gggcggagcc aacgagggcg ccaggaccgc cctgagcgtg      780

gtgacctgga acaaggacat cgtgaccaag atcacccccg agggcgccga agagtggtga      840


<210>  92
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV E1 consensus

<400>  92
tacgagcacg tgaccgtgat ccccaacacc gtgggcgtgc cctacaagac cctggtgaac       60

aggcccggct acagccccat ggtgctggaa atggaactgc tgtccgtgac cctggaaccc      120

accctgagcc tggactacat cacctgcgag tacaagacag tgatccccag cccctacgtg      180

aagtgctgcg gcaccgccga gtgcaaggac aagaacctgc ccgactacag ctgcaaggtg      240

ttcaccggcg tgtacccctt catgtggggc ggagcctact gcttctgcga cgccgagaac      300

acccagctgt ccgaggccca cgtggagaag agcgagagct gcaagaccga gttcgccagc      360

gcctaccggg cccacacagc cagcgccagc gccaagctgc gggtgctgta ccagggcaac      420

aacatcaccg tgaccgccta cgccaacggc gaccacgccg tgacagtgaa ggacgccaag      480

ttcatcgtgg gccccatgag cagcgcctgg acccccttcg acaacaagat cgtggtgtac      540

aagggcgacg tgtacaacat ggactacccc cccttcggag ccggcagacc cggccagttc      600

ggcgacatcc agagccggac ccccgagagc aaggacgtgt acgccaatac ccagctggtg      660

ctgcagagac ccgccgtggg caccgtgcac gtgccttaca gccaggcccc cagcggcttc      720

aagtactggc tgaaagagag gggcgccagc ctgcagcaca ccgccccctt cggctgccag      780

atcgccacca accccgtgcg ggccgtgaat tgtgccgtgg gcaacatgcc catcagcatc      840

gacatccccg aggccgcctt caccagggtg gtggacgccc ccagcctgac cgacatgagc      900

tgcgaggtgc ccgcctgcac ccacagcagc gacttcggcg gcgtggccat catcaagtac      960

gccgccagca agaaaggcaa gtgcgccgtg cacagcatga ccaatgccgt gaccatccgg     1020

gaggccgaga tcgaggtgga gggcaacagc cagctgcaga tcagcttcag caccgccctg     1080

gccagcgccg agttccgggt gcaggtctgc agcacccagg tgcactgtgc cgccgagtgt     1140

caccccccca aggaccacat cgtgaactac cccgccagcc acaccaccct gggcgtgcag     1200

gacatcagcg ccaccgccat gagctgggtg cagaagatca caggcggcgt cggcctggtg     1260

gtggccgtgg ccgccctgat cctgatcgtg gtgctgtgcg tgagcttcag ccggcactga     1320


<210>  93
<211>  1273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV E1 consensus

<400>  93
cagcaccaag gacaacttca acgtgtacaa ggccacccgg ccctacctgg cccactgccc       60

cgattgcggc gagggccaca gctgccacag ccccgtggcc ctggaacgga tccggaacga      120

ggccaccgac ggcaccctga agatccaggt gtccctgcag atcggcatca agaccgacga      180

cagccacgac tggaccaagc tgcggtacat ggacaaccac atgcccgccg acgccgagag      240

agccggcctg ttcgtccgga ccagcgcccc ctgcaccatc accggcacca tgggccactt      300

catcctggcc cggtgcccca agggcgagac actgaccgtg ggcttcaccg acagccggaa      360

gatcagccac tcctgcaccc accccttcca ccacgacccc cccgtgatcg gccgggagaa      420

gttccacagc aggccccagc acggcaaaga gctgccctgc agcacctacg tgcagagcac      480

cgccgccaca accgaggaaa tcgaggtgca catgcccccc gatacccccg accggaccct      540

gatgagccag cagagcggca acgtgaagat caccgtgaac ggccagaccg tgcggtacaa      600

gtgcaactgc ggcggcagca acgagggcct gaccaccacc gacaaggtga tcaacaactg      660

caaggtggac cagtgccacg ccgccgtgac caaccacaag aagtggcagt acaacagccc      720

cctggtgccc cggaatgccg agctgggcga ccggaagggc aagatccaca tccccttccc      780

cctggccaac gtgacctgcc gggtgcccaa ggcccggaac cccaccgtga cctacggcaa      840

gaaccaggtg atcatgctgc tgtaccccga ccaccccacc ctgctgtcct accggaacat      900

gggcgaggaa cccaactacc aagaggagtg ggtcatgcac aagaaagaag tggtgctgac      960

cgtccccacc gagggcctgg aagtgacctg gggcaacaac gagccctaca agtactggcc     1020

ccagctgtcc accaacggca ccgcccacgg ccacccccac gagatcatcc tgtactacta     1080

cgagctgtac cctaccatga ccgtggtggt ggtgtccgtg gccaccttta tcctgctgtc     1140

catggtcggc atggccgctg gcatgtgcat gtgcgccagg aggcgctgta tcacccccta     1200

cgagctgaca cctggcgcca ccgtgccctt tctgctgtcc ctgatctgct gcatccggac     1260

cgccaaggcc tga                                                        1273


<210>  94
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV capsid consensus

<400>  94
atggaattca tccccaccca gaccttctac aaccggcgct accagcccag accctggacc       60

cccaggccca ccatccaggt gatccggccc aggcccagac cccagaggca ggccgggcag      120

ctggcacagc tgatcagcgc cgtgaacaag ctgaccatga gagccgtgcc ccagcagaag      180

cccaggcgga accggaagaa caagaagcag aagcagaaac agcaggcccc ccagaacaac      240

accaaccaga agaagcagcc ccccaagaag aagcctgccc agaagaagaa gaaacccggc      300

aggcgggagc ggatgtgcat gaagatcgag aacgactgca tcttcgaggt gaagcacgag      360

ggcaaggtga ccggctacgc ctgcctggtc ggcgacaaag tgatgaagcc cgcccacgtg      420

aagggcacca tcgacaacgc cgacctggcc aagctggcct tcaagcggag cagcaagtac      480

gacctggaat gcgcccagat ccccgtgcac atgaagagcg acgccagcaa gttcacccac      540

gagaagcccg agggctacta caactggcac cacggagccg tgcagtacag cggcggcagg      600

ttcaccatcc ccacaggcgc cggaaagccc ggcgacagcg gcaggcccat cttcgacaac      660

aagggccggg tggtggccat cgtgctgggc ggagccaacg agggcgccag gaccgccctg      720

agcgtggtga cctggaacaa ggacatcgtg accaagatca cccccgaggg cgccgaagag      780

tggtga                                                                 786


<210>  95
<211>  3008
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV Env consensus

<400>  95
atggactgga cctggatcct gttcctggtg gctgctgcca cccgcgtgca cagcagcctg       60

gccatccccg tgatgtgcct gctggccaac accaccttcc cttgcagcca gcccccctgc      120

accccctgct gctacgagaa agagcccgag gaaaccctgc ggatgctgga agataacgtg      180

atgaggcccg gctactacca gctgctccag gccagcctga cctgctcccc ccaccggcag      240

cggcggcgcg ggcgcaaacg ccgctctgcc accatggact ggacctggat cctgttcctg      300

gtcgctgctg ccacaagagt gcacagcagc accaaggaca acttcaacgt gtacaaggcc      360

acccggccct acctggccca ctgccccgat tgcggcgagg gccacagctg ccacagcccc      420

gtggccctgg aacggatccg gaacgaggcc accgacggca ccctgaagat ccaggtgtcc      480

ctgcagatcg gcatcaagac cgacgacagc cacgactgga ccaagctgcg gtacatggac      540

aaccacatgc ccgccgacgc cgagagagcc ggcctgttcg tccggaccag cgccccctgc      600

accatcaccg gcaccatggg ccacttcatc ctggcccggt gccccaaggg cgagacactg      660

accgtgggct tcaccgacag ccggaagatc agccactcct gcacccaccc cttccaccac      720

gacccccccg tgatcggccg ggagaagttc cacagcaggc cccagcacgg caaagagctg      780

ccctgcagca cctacgtgca gagcaccgcc gccacaaccg aggaaatcga ggtgcacatg      840

ccccccgata cccccgaccg gaccctgatg agccagcaga gcggcaacgt gaagatcacc      900

gtgaacggcc agaccgtgcg gtacaagtgc aactgcggcg gcagcaacga gggcctgacc      960

accaccgaca aggtgatcaa caactgcaag gtggaccagt gccacgccgc cgtgaccaac     1020

cacaagaagt ggcagtacaa cagccccctg gtgccccgga atgccgagct gggcgaccgg     1080

aagggcaaga tccacatccc cttccccctg gccaacgtga cctgccgggt gcccaaggcc     1140

cggaacccca ccgtgaccta cggcaagaac caggtgatca tgctgctgta ccccgaccac     1200

cccaccctgc tgtcctaccg gaacatgggc gaggaaccca actaccaaga ggagtgggtc     1260

atgcacaaga aagaagtggt gctgaccgtc cccaccgagg gcctggaagt gacctggggc     1320

aacaacgagc cctacaagta ctggccccag ctgtccacca acggcaccgc ccacggccac     1380

ccccacgaga tcatcctgta ctactacgag ctgtacccta ccatgaccgt ggtggtggtg     1440

tccgtggcca cctttatcct gctgtccatg gtcggcatgg ccgctggcat gtgcatgtgc     1500

gccaggaggc gctgtatcac cccctacgag ctgacacctg gcgccaccgt gccctttctg     1560

ctgtccctga tctgctgcat ccggaccgcc aaggcccgcg ggcgcaaacg ccgctctgcc     1620

accatggact ggacctggat cctgtttctg gtcgctgctg ccacccgggt gcacagctac     1680

gagcacgtga ccgtgatccc caacaccgtg ggcgtgccct acaagaccct ggtgaacagg     1740

cccggctaca gccccatggt gctggaaatg gaactgctgt ccgtgaccct ggaacccacc     1800

ctgagcctgg actacatcac ctgcgagtac aagacagtga tccccagccc ctacgtgaag     1860

tgctgcggca ccgccgagtg caaggacaag aacctgcccg actacagctg caaggtgttc     1920

accggcgtgt accccttcat gtggggcgga gcctactgct tctgcgacgc cgagaacacc     1980

cagctgtccg aggcccacgt ggagaagagc gagagctgca agaccgagtt cgccagcgcc     2040

taccgggccc acacagccag cgccagcgcc aagctgcggg tgctgtacca gggcaacaac     2100

atcaccgtga ccgcctacgc caacggcgac cacgccgtga cagtgaagga cgccaagttc     2160

atcgtgggcc ccatgagcag cgcctggacc cccttcgaca acaagatcgt ggtgtacaag     2220

ggcgacgtgt acaacatgga ctaccccccc ttcggagccg gcagacccgg ccagttcggc     2280

gacatccaga gccggacccc cgagagcaag gacgtgtacg ccaataccca gctggtgctg     2340

cagagacccg ccgtgggcac cgtgcacgtg ccttacagcc aggcccccag cggcttcaag     2400

tactggctga aagagagggg cgccagcctg cagcacaccg cccccttcgg ctgccagatc     2460

gccaccaacc ccgtgcgggc cgtgaattgt gccgtgggca acatgcccat cagcatcgac     2520

atccccgagg ccgccttcac cagggtggtg gacgccccca gcctgaccga catgagctgc     2580

gaggtgcccg cctgcaccca cagcagcgac ttcggcggcg tggccatcat caagtacgcc     2640

gccagcaaga aaggcaagtg cgccgtgcac agcatgacca atgccgtgac catccgggag     2700

gccgagatcg aggtggaggg caacagccag ctgcagatca gcttcagcac cgccctggcc     2760

agcgccgagt tccgggtgca ggtctgcagc acccaggtgc actgtgccgc cgagtgtcac     2820

ccccccaagg accacatcgt gaactacccc gccagccaca ccaccctggg cgtgcaggac     2880

atcagcgcca ccgccatgag ctgggtgcag aagatcacag gcggcgtcgg cctggtggtg     2940

gccgtggccg ccctgatcct gatcgtggtg ctgtgcgtga gcttcagccg gcactgatga     3000

gcggccgc                                                              3008


<210>  96
<211>  2954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIKV Env consensus

<400>  96
agcctggcca tccccgtgat gtgcctgctg gccaacacca ccttcccttg cagccagccc       60

ccctgcaccc cctgctgcta cgagaaagag cccgaggaaa ccctgcggat gctggaagat      120

aacgtgatga ggcccggcta ctaccagctg ctccaggcca gcctgacctg ctccccccac      180

cggcagcggc ggcgcgggcg caaacgccgc tctgccacca tggactggac ctggatcctg      240

ttcctggtcg ctgctgccac aagagtgcac agcagcacca aggacaactt caacgtgtac      300

aaggccaccc ggccctacct ggcccactgc cccgattgcg gcgagggcca cagctgccac      360

agccccgtgg ccctggaacg gatccggaac gaggccaccg acggcaccct gaagatccag      420

gtgtccctgc agatcggcat caagaccgac gacagccacg actggaccaa gctgcggtac      480

atggacaacc acatgcccgc cgacgccgag agagccggcc tgttcgtccg gaccagcgcc      540

ccctgcacca tcaccggcac catgggccac ttcatcctgg cccggtgccc caagggcgag      600

acactgaccg tgggcttcac cgacagccgg aagatcagcc actcctgcac ccaccccttc      660

caccacgacc cccccgtgat cggccgggag aagttccaca gcaggcccca gcacggcaaa      720

gagctgccct gcagcaccta cgtgcagagc accgccgcca caaccgagga aatcgaggtg      780

cacatgcccc ccgatacccc cgaccggacc ctgatgagcc agcagagcgg caacgtgaag      840

atcaccgtga acggccagac cgtgcggtac aagtgcaact gcggcggcag caacgagggc      900

ctgaccacca ccgacaaggt gatcaacaac tgcaaggtgg accagtgcca cgccgccgtg      960

accaaccaca agaagtggca gtacaacagc cccctggtgc cccggaatgc cgagctgggc     1020

gaccggaagg gcaagatcca catccccttc cccctggcca acgtgacctg ccgggtgccc     1080

aaggcccgga accccaccgt gacctacggc aagaaccagg tgatcatgct gctgtacccc     1140

gaccacccca ccctgctgtc ctaccggaac atgggcgagg aacccaacta ccaagaggag     1200

tgggtcatgc acaagaaaga agtggtgctg accgtcccca ccgagggcct ggaagtgacc     1260

tggggcaaca acgagcccta caagtactgg ccccagctgt ccaccaacgg caccgcccac     1320

ggccaccccc acgagatcat cctgtactac tacgagctgt accctaccat gaccgtggtg     1380

gtggtgtccg tggccacctt tatcctgctg tccatggtcg gcatggccgc tggcatgtgc     1440

atgtgcgcca ggaggcgctg tatcaccccc tacgagctga cacctggcgc caccgtgccc     1500

tttctgctgt ccctgatctg ctgcatccgg accgccaagg cccgcgggcg caaacgccgc     1560

tctgccacca tggactggac ctggatcctg tttctggtcg ctgctgccac ccgggtgcac     1620

agctacgagc acgtgaccgt gatccccaac accgtgggcg tgccctacaa gaccctggtg     1680

aacaggcccg gctacagccc catggtgctg gaaatggaac tgctgtccgt gaccctggaa     1740

cccaccctga gcctggacta catcacctgc gagtacaaga cagtgatccc cagcccctac     1800

gtgaagtgct gcggcaccgc cgagtgcaag gacaagaacc tgcccgacta cagctgcaag     1860

gtgttcaccg gcgtgtaccc cttcatgtgg ggcggagcct actgcttctg cgacgccgag     1920

aacacccagc tgtccgaggc ccacgtggag aagagcgaga gctgcaagac cgagttcgcc     1980

agcgcctacc gggcccacac agccagcgcc agcgccaagc tgcgggtgct gtaccagggc     2040

aacaacatca ccgtgaccgc ctacgccaac ggcgaccacg ccgtgacagt gaaggacgcc     2100

aagttcatcg tgggccccat gagcagcgcc tggaccccct tcgacaacaa gatcgtggtg     2160

tacaagggcg acgtgtacaa catggactac ccccccttcg gagccggcag acccggccag     2220

ttcggcgaca tccagagccg gacccccgag agcaaggacg tgtacgccaa tacccagctg     2280

gtgctgcaga gacccgccgt gggcaccgtg cacgtgcctt acagccaggc ccccagcggc     2340

ttcaagtact ggctgaaaga gaggggcgcc agcctgcagc acaccgcccc cttcggctgc     2400

cagatcgcca ccaaccccgt gcgggccgtg aattgtgccg tgggcaacat gcccatcagc     2460

atcgacatcc ccgaggccgc cttcaccagg gtggtggacg cccccagcct gaccgacatg     2520

agctgcgagg tgcccgcctg cacccacagc agcgacttcg gcggcgtggc catcatcaag     2580

tacgccgcca gcaagaaagg caagtgcgcc gtgcacagca tgaccaatgc cgtgaccatc     2640

cgggaggccg agatcgaggt ggagggcaac agccagctgc agatcagctt cagcaccgcc     2700

ctggccagcg ccgagttccg ggtgcaggtc tgcagcaccc aggtgcactg tgccgccgag     2760

tgtcaccccc ccaaggacca catcgtgaac taccccgcca gccacaccac cctgggcgtg     2820

caggacatca gcgccaccgc catgagctgg gtgcagaaga tcacaggcgg cgtcggcctg     2880

gtggtggccg tggccgccct gatcctgatc gtggtgctgt gcgtgagctt cagccggcac     2940

tgatgagcgg ccgc                                                       2954


<210>  97
<211>  2223
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid sequence encoding CHIKV1-IgG

<400>  97
ggatccgcca ccatggactg gacttggatt ctgtttctgg tcgccgccgc tacccgagtg       60

cattcacagg tgcagctgca gcagcctggg gccgctctgg tgaagccagg agctagcgca      120

atgatgtcct gcaaagcctc tggctacact ttcacctcct attggatcac ctgggtgaag      180

cagcgacctg gacagggact ggagtggatc ggcgacatct acccaggcac cgggagaaca      240

atctacaagg aaaaattcaa gacaaaagcc acactgactg tggacaccag ctcctctaca      300

gcttttatgc agctgaacag cctgacttcc gaggatagcg ccgtgtacta ttgcgcaaga      360

ggatacggct ctccttacta tgccctggac tattgggggc agggaactag cgtcaccgtg      420

agttcagcat ctaccaaggg accaagcgtg ttcccactgg cacctagctc caaatccact      480

tctggcggga ccgccgctct gggatgtctg gtgaaggatt acttccctga gccagtcaca      540

gtgagttgga actcaggggc tctgaccagc ggagtccaca catttcctgc agtgctgcag      600

tctagtggac tgtactccct gtcaagcgtg gtcactgtcc catcctctag tctgggcacc      660

cagacatata tctgcaacgt gaatcacaag ccatccaata ccaaagtcga taagaaagtg      720

gagcccaagt cttgtgacaa aactcatacc tgccctccct gtccagcacc tgaactgctg      780

ggaggcccaa gcgtgttcct gtttccaccc aagcctaaag acaccctgat gattagcagg      840

acaccagagg tcacttgcgt ggtcgtggac gtgagccacg aagaccccga ggtcaagttc      900

aactggtacg tggatggcgt cgaagtgcat aatgccaaga caaaaccccg ggaggaacag      960

tacaactcaa cctatcgggt cgtgagcgtc ctgacagtgc tgcaccagga ctggctgaac     1020

ggaaaggagt acaagtgcaa agtgtctaat aaggccctgc cagctcccat cgaaaaaacc     1080

attagcaagg ctaaaggcca gccaagagag ccccaggtgt acacactgcc tccatcaagg     1140

gacgaactga caaagaacca ggtcagcctg acttgtctgg tgaaaggctt ctatcccagc     1200

gatatcgcag tggaatggga gtccaatggg cagcctgaga acaattacaa gaccacaccc     1260

cctgtgctgg acagcgatgg gtccttcttt ctgtattcca agctgacagt ggataaatct     1320

cggtggcagc agggaaacgt ctttagttgc tcagtgatgc acgaagccct gcacaatcat     1380

tacactcaga agagcctgtc cctgtctccc ggaaagaggg gccgcaaacg gagaagtggc     1440

tcaggggcaa ccaacttctc tctgctgaaa caggccggcg atgtggagga aaatcctggg     1500

ccaatggact ggacatggat tctgttcctg gtggcagccg ctacaagggt ccattccgac     1560

attgtgctga ctcagtctcc tgcaagtctg gccgtgtctc agggacagcg agcaaccatc     1620

agttgtaagg ctagccagtc cgtcgactac gatggggaca gttacgtgaa ctggtatcag     1680

cagaagcctg gacagtcccc aaaactgctg atctatgatg ctagtaatct ggagtcaggc     1740

attcccgcac gattctctgg aagtggctca gggacagact tcaccctgaa cattcaccct     1800

gtcgaggaag aggacgtggc tacctactat tgccaggaaa gcaatgagga cccccgcact     1860

ttcgggggag gcaccaagct ggagatcaaa cgaactgtcg cagcccccag cgtgttcatc     1920

tttccaccct cagacgaaca gctgaagagc ggaaccgcat ccgtggtgtg cctgctgaac     1980

aacttctacc cccgcgaggc caaggtccag tggaaagtgg ataacgctct gcagtcaggc     2040

aatagccagg aatccgtgac tgagcaggat tctaaggaca gtacctattc actgtcaagc     2100

acactgactc tgagcaaagc agactacgaa aagcataaag tgtatgcctg cgaagtcacc     2160

caccaggggc tgaggtctcc agtcactaag tctttcaaca gaggggaatg ctgataactc     2220

gag                                                                   2223


<210>  98
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding CHIKV2-IgG

<400>  98
ggatccgcca ccatggattg gacatggatt ctgtttctgg tcgccgccgc cacaagggtc       60

cactctcagg tgcagctggt gcagtcaggc tccgaactga agaaacccgg agcttctgtc      120

aaggtgagtt gcaaagcatc agggtacact ctgaccagat atgcaatgac ctgggtgcgg      180

caggcacctg gacagggact ggagtggatg ggctggatca acacatacac tggaaatcca      240

acttatgtgc agggcttcac cggacggttc gtcttttctc tggacacaag cgtgtccact      300

gcctttctgc acattacaag cctgaaggca gaggacactg ccgtgtactt ctgcgcccga      360

gaaggcggag ctaggggctt tgattattgg gggcagggca cactggtcac tgtgagctcc      420

gcttctacaa agggacctag cgtgttccca ctggcaccct ctagtaaatc taccagtggg      480

ggcacagccg ctctgggatg tctggtgaag gattacttcc ccgagcctgt caccgtgtca      540

tggaacagcg gggcactgac ctccggagtc catacatttc ccgccgtgct gcagtcaagc      600

ggactgtaca gcctgtcctc tgtggtcact gtgcctagtt caagcctggg gacccagaca      660

tatatctgca acgtgaatca caagccttct aataccaagg tcgacaaaag ggtggaacca      720

aagagctgtg ataaaactca tacctgccct ccctgtccag ctccagagct gctgggaggg      780

ccatccgtgt tcctgtttcc acccaagcct aaagacacac tgatgatttc cagaactcca      840

gaagtcacct gcgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      900

tacgtggatg gcgtcgaggt gcataatgcc aagaccaaac ccagggagga acagtacaac      960

tcaacatata gagtcgtgag cgtcctgact gtgctgcacc aggactggct gaacggcaag     1020

gagtataagt gcaaagtgag caataaggcc ctgcctgctc caatcgagaa aacaatttcc     1080

aaggctaaag gccagcctcg ggaaccacag gtgtacactc tgcctccaag tcgcgacgag     1140

ctgaccaaga accaggtctc tctgacatgt ctggtgaaag gcttttatcc cagtgatatc     1200

gccgtggagt gggaatcaaa tggacagcct gaaaacaatt acaagaccac accccctgtg     1260

ctggactccg atggatcttt ctttctgtat tccaagctga cagtggataa atctcgctgg     1320

cagcagggga acgtcttctc atgcagcgtg atgcacgagg ccctgcacaa tcattacact     1380

cagaagtccc tgtctctgag tcctgggaag cggggccgca aaaggagatc aggaagcggg     1440

gccaccaact ttagcctgct gaaacaggct ggggacgtgg aggaaaatcc cggccctatg     1500

gactggacct ggattctgtt cctggtggca gccgctaccc gagtccattc ccagtctgtg     1560

ctgacacagc cacccagtgt ctcaggagca ccaggacagc gagtgacaat cagctgtact     1620

ggcagcagca gcaacattgg ggcctcccac gacgtgcatt ggtaccagca gctgcccggc     1680

accgctccta cactgctgat ctatgtcaac agcaatcgcc catccggagt gcccgatcga     1740

ttcagcggct ccaagtctgg aactagtgca tcactggcca ttaccggcct gcaggctgag     1800

gacgaagcag attactattg ccagagttac gactcaaacc tgagcgggtc cgccgtcttc     1860

ggcggaggga ctaagctgac cgtgctgggc cagcctaaag cagccccatc cgtgaccctg     1920

tttcctccat caagcgagga actgcaggct aataaggcca ccctggtgtg cctgatcagc     1980

gacttctacc caggagcagt caccgtggca tggaaggctg attcctctcc agtcaaagcc     2040

ggcgtggaaa ctaccacacc cagcaagcag tccaacaaca agtacgctgc aagttcatat     2100

ctgtccctga cccccgagca gtggaagtct cacaaatctt atagttgcca ggtgacccat     2160

gaaggctcaa ctgtggaaaa aactgtcgct cctactgaat gctcatgata actcgag        2217


<210>  99
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding CHIKV3-IgG

<400>  99
ggatccgcca ccatggattg gacatggatt ctgtttctgg tcgctgctgc cacacgggtg       60

cattctcagg tccagctgca ggagtcaggg ccagggctgg tcaagccttc cgaaaccctg      120

tctctgacat gcaccgtgag cggcgacagt atcagctcct actcatggag ctggattcgg      180

cagccccctg gcaaaggact ggagtggatc ggctacattc actatacagg aagcactaac      240

tataatccat cactgaagag ccgcctgacc atcagtgtgg acgcctcaaa aaaccagttc      300

tccctgaagc tgtctagtgt cactgccgct gacaccgccg tgtactattg cgcacgggat      360

tggggcggat actcaagctc ctggacatat gggatggacg tgtgggggca gggcaccaca      420

gtcacagtgt ctagtgcaag cactaaaggc ccctccgtgt ttccactggc cccctcaagc      480

aagtccacat ctgggggcac tgcagccctg ggatgtctgg tgaaggatta cttccccgag      540

cctgtcaccg tgtcctggaa ctctggagcc ctgacttccg gggtccatac ctttcccgct      600

gtgctgcagt cctctgggct gtactctctg agttcagtgg tcacagtgcc tagctcctct      660

ctgggcaccc agacatatat ctgcaacgtg aatcacaagc ctagcaatac taaggtcgac      720

aaaagggtgg aaccaaaaag ctgtgataag actcatacct gcccaccctg tccagcacca      780

gagctgctgg gagggccaag cgtgttcctg tttcctccaa agcccaaaga caccctgatg      840

atttccagaa ccccagaagt cacatgcgtg gtcgtggacg tgtctcacga ggaccccgaa      900

gtcaagttca actggtacgt ggatggcgtc gaggtgcata atgctaagac aaaaccacgc      960

gaggaacagt acaattctac atatcgagtc gtgagtgtcc tgactgtgct gcaccaggac     1020

tggctgaacg gaaaggagta caagtgcaaa gtgagcaaca aggccctgcc tgccccaatc     1080

gagaagacaa ttagcaaggc taaagggcag cctagggaac cacaggtgta cactctgccc     1140

ccttccagag acgagctgac caaaaaccag gtctctctga catgtctggt gaagggcttc     1200

tatcccagcg atatcgcagt ggagtgggaa agcaatggac agcctgaaaa caattacaag     1260

actaccccac ccgtgctgga cagtgatggc tcattctttc tgtattcaaa actgaccgtg     1320

gataagagcc ggtggcagca gggaaacgtc tttagttgct cagtgatgca cgaggccctg     1380

cacaatcatt acacacagaa aagcctgtcc ctgtctcctg ggaaacgggg ccgcaagagg     1440

agaagtggat caggggccac taacttcagc ctgctgaagc aggctgggga cgtggaggaa     1500

aatcccggcc ctatggattg gacctggatt ctgttcctgg tcgctgcagc cactcgcgtg     1560

cattccgaca ttcagatgac ccagtctccc agttcactga gcgcctccgt cggagatcga     1620

gtgacaatca cttgtagggc aagccagggg atttctaaca gtctggcctg gtaccagcag     1680

aagcccggaa aagctcctaa gctgctgctg tatgctgcaa gcagactgga atccggggtg     1740

ccttctcggt tctcaggcag cggcagcgga accgactaca ccctgacaat tagctccctg     1800

cagcctgagg atttcgccac atactattgc cagcagtact attccacccc atatacattt     1860

ggccagggaa ctaaactgga aatcaagcga accgtcgccg ctccaagcgt gttcatcttt     1920

cctccatctg acgagcagct gaagagtgga accgcttcag tggtgtgcct gctgaacaac     1980

ttctaccccc gcgaggcaaa agtccagtgg aaggtggata acgccctgca gagcggcaat     2040

tcccaggagt ctgtgaccga acaggacagt aaagattcaa catatagcct gtctagtact     2100

ctgaccctga gcaaggctga ctacgagaag cacaaagtgt atgcatgcga agtgacccac     2160

caggggctga gttctccagt gactaaatct ttcaacagag gcgaatgttg ataactcgag     2220


<210>  100
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic Acid Sequence encoding CHIKV4-IgG

<400>  100
ggatccgcca ccatggactg gacatggatt ctgttcctgg tcgctgctgc tactcgggtg       60

catagcgaag tgaggctggt cgaaagtggg ggcgggctgg agcagcccgg cggcagcctg      120

aagctgtctt gcgccgctag tggcttcacc tttagcgact acttcatgta ttgggtcaga      180

cagacacctg agaagcggct ggaatgggtg gcctacatca gcaacggcgg aatttcaaca      240

ttctatagcg acgccgtgaa aggccggttt accatctccc gagataacgc taggaataca      300

ctgtacctgc agatgtcccg gctgaagtct gaagacacag caatctacta ttgcgtccgc      360

caggtgtatg ggcagggcta cttcgattat tggggacagg ggaccacact ggctgtcagc      420

tccgcaagca ctaagggacc ctccgtgttt cccctggccc cttctagtaa aagtacctca      480

ggagggacag cagccctggg gtgtctggtg aaggactact tccctgagcc agtcaccgtg      540

tcatggaaca gcggagctct gacatccggg gtccacactt ttcctgcagt gctgcagtca      600

agcggactgt actctctgtc ctctgtggtc accgtgccaa gttcaagcct ggggacacag      660

acttatatct gcaacgtgaa tcacaagcca tccaatacaa aagtcgacaa gaaagtggaa      720

cccaagtctt gtgataaaac ccatacatgc cctccctgtc cagctcctga gctgctgggc      780

ggaccatccg tgttcctgtt tccacccaag cctaaagaca cactgatgat tagccggact      840

cccgaagtca cctgcgtggt cgtggacgtg tcccacgagg accccgaagt caagttcaac      900

tggtacgtgg atggcgtcga ggtgcataat gccaagacca aacctcgcga ggaacagtac      960

aactctactt atcgagtcgt gagtgtcctg accgtgctgc accaggactg gctgaacggc     1020

aaggagtata agtgcaaagt gtctaataag gcactgccag cccccatcga gaaaactatt     1080

agcaaggcta aaggacagcc aagggaaccc caggtgtaca ccctgcctcc atctagagac     1140

gagctgacca agaaccaggt cagcctgaca tgtctggtga aagggttcta tccttctgat     1200

atcgcagtgg agtgggaaag taatggccag ccagaaaaca attacaagac tacccctccc     1260

gtgctggact ccgatgggtc tttctttctg tattcaaagc tgaccgtgga taaaagccgc     1320

tggcagcagg gcaacgtctt tagctgctcc gtgatgcatg aggccctgca caatcattac     1380

actcagaaat ctctgagtct gtcaccaggg aagcgaggac gaaaaaggag aagcggctcc     1440

ggagctacca acttcagcct gctgaagcag gcaggcgacg tggaggaaaa tcctggacca     1500

atggattgga cttggattct gttcctggtg gctgcagcca cccgagtcca ctcccagatc     1560

gtgctgattc agtctccagc cattatgtct gctagtctgg gcgagcgcgt cactatgacc     1620

tgtacagcca gcagcagcgt gagcagcagc tacctgcatt ggtatcagca gaagcctggc     1680

tctagtccaa aactgtggat ctactcaagc ttcagtctgg catcaggagt gccagcaagg     1740

ttttcaggga gcggctccgg aacatcttac agtctgacaa ttagcactat ggaggctgaa     1800

gacgctgcaa cttactattg ccaccagtat ctgagaagcc catggacctt cggcggcggc     1860

agcaagctgg aaatcaaaac tgtcgccgct cccagcgtgt tcatctttcc accctcagac     1920

gagcagctga agagtgggac cgcctcagtg gtgtgcctgc tgaacaactt ctaccctaga     1980

gaagccaagg tccagtggaa agtggataac gctctgcaga gcggaaattc ccaggagtct     2040

gtgacagaac aggacagtaa ggattcaact tatagcctgt cctctactct gaccctgtcc     2100

aaagcagatt acgagaagca taaagtgtat gcctgcgagg tcacccacca ggggctgcgg     2160

tctcccgtca caaagagctt caacaggggc gaatgttgat aactcgag                  2208


<210>  101
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-3F12E9-VH

<400>  101

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala 
    130             


<210>  102
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-3F12E9-VL

<400>  102

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  103
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8A9F9-VH

<400>  103

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  104
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8A9F9-VL

<400>  104

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Arg Ser Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  105
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8D10F4-VH

<400>  105

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Lys Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr 
        


<210>  106
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8D10F4-VL

<400>  106

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  107
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-IC2A6-VH

<400>  107

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  108
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-IC2A6-VH

<400>  108

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Cys Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  109
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-ID4G7-VH

<400>  109

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  110
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-ID4G7-VL

<400>  110

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Phe Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  111
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (3F12E9)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  111

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala His 
225                 230                 235                 240 


His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys 
    450                 455                 460                 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
                485                 490                 495     


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val Val 
            500                 505                 510         


Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala 
        515                 520                 525             


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys 
    530                 535                 540                 


Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg 
545                 550                 555                 560 


Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe 
                565                 570                 575     


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
            580                 585                 590         


Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe 
        595                 600                 605             


Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  112
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG heavy signal peptide-VH-CH1-Hinge Region-CH2-CH3-custom
       Furin cleavage site-'GSG' Linker and P2A Peptide-human kappa 
       light chain signal peptide-VL-CL (kappa)

<400>  112

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg 
    450                 455                 460                 


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
465                 470                 475                 480 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
                485                 490                 495     


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
            500                 505                 510         


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
        515                 520                 525             


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
    530                 535                 540                 


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
            580                 585                 590         


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
        595                 600                 605             


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  113
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG heavy signal peptide-VH-CH1-Hinge Region-CH2-CH3-custom
       Furin cleavage site-'GSG' Linker and P2A Peptide-human kappa 
       light chain signal peptide-VL-CL (kappa)

<400>  113

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala 
225                 230                 235                 240 


His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
465                 470                 475                 480 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
                485                 490                 495     


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val 
            500                 505                 510         


Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
        515                 520                 525             


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
    530                 535                 540                 


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
            580                 585                 590         


Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Ser Thr His 
        595                 600                 605             


Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    610                 615                 620                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
625                 630                 635                 640 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                645                 650                 655     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            660                 665                 670         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        675                 680                 685             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    690                 695                 700                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
705                 710                 715                 720 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 


<210>  114
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8A9F9)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  114

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  115
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8D10F4)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  115

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala 
225                 230                 235                 240 


His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
465                 470                 475                 480 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
                485                 490                 495     


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val 
            500                 505                 510         


Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
        515                 520                 525             


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
    530                 535                 540                 


Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
            580                 585                 590         


Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser Thr His 
        595                 600                 605             


Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  116
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8D10F4)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  116

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  117
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (1D4G7)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  117

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
                245                 250                 255     


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asn Ile Val Leu Thr Gln 
        515                 520                 525             


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
    530                 535                 540                 


Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
545                 550                 555                 560 


Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu 
                565                 570                 575     


Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
            580                 585                 590         


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
625                 630                 635                 640 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                645                 650                 655     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            660                 665                 670         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        675                 680                 685             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    690                 695                 700                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
705                 710                 715                 720 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                725                 730                 735     


Arg Gly Glu Cys 
            740 


<210>  118
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (1D4G7)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  118

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys 
465                 470                 475                 480 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
            500                 505                 510         


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asn Ile Val 
        515                 520                 525             


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
    530                 535                 540                 


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser 
545                 550                 555                 560 


Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                565                 570                 575     


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
            580                 585                 590         


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu 
        595                 600                 605             


Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Tyr Pro 
    610                 615                 620                 


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
625                 630                 635                 640 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                645                 650                 655     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            660                 665                 670         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        675                 680                 685             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    690                 695                 700                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
705                 710                 715                 720 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                725                 730                 735     


Ser Phe Asn Arg Gly Glu Cys 
            740             


<210>  119
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8A9F9)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2 (with LALA variant at 4th and 5th
       residue)-CH3-custom Furin cleavage site-'GSG' Linker and P2A 
       Peptide-human kappa light chain signal peptide-VL-CL (kappa)

<400>  119

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  120
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (3F12E9)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2 (with LALA variant at 4th and 5th
       residue)-CH3-custom Furin cleavage site-'GSG' Linker and P2A 
       Peptide-human kappa light chain signal peptide-VL-CL (kappa)

<400>  120

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg 
    450                 455                 460                 


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
465                 470                 475                 480 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
                485                 490                 495     


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
            500                 505                 510         


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
        515                 520                 525             


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
    530                 535                 540                 


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
            580                 585                 590         


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
        595                 600                 605             


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  121
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (IC2A6)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  121

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Val Thr Gly Arg Phe Thr Ile Ser Arg Asp 
    130                 135                 140                 


Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu 
145                 150                 155                 160 


Asp Thr Ala Met Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp 
                165                 170                 175     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
            180                 185                 190         


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
        195                 200                 205             


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
    210                 215                 220                 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
225                 230                 235                 240 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
                245                 250                 255     


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
            260                 265                 270         


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met 
        275                 280                 285             


Val Pro His Ala His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                325                 330                 335     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            500                 505                 510         


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
        515                 520                 525             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
    530                 535                 540                 


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
545                 550                 555                 560 


Tyr Gly Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Cys 
                565                 570                 575     


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
            580                 585                 590         


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
        595                 600                 605             


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    610                 615                 620                 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
625                 630                 635                 640 


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe 
                645                 650                 655     


Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            660                 665                 670         


Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        675                 680                 685             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    690                 695                 700                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
705                 710                 715                 720 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                725                 730                 735     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            740                 745                 750         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        755                 760                 765             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    770                 775                 780 


<210>  122
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (IC2A6)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  122

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Val Thr Gly Arg Phe Thr Ile Ser Arg Asp 
    130                 135                 140                 


Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu 
145                 150                 155                 160 


Asp Thr Ala Met Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp 
                165                 170                 175     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
            180                 185                 190         


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
        195                 200                 205             


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
    210                 215                 220                 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
225                 230                 235                 240 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
                245                 250                 255     


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
            260                 265                 270         


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
        275                 280                 285             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
        515                 520                 525             


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
545                 550                 555                 560 


Ser Gly Ala Tyr Gly Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
                565                 570                 575     


Pro Val Cys Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
            580                 585                 590         


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
        595                 600                 605             


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
    610                 615                 620                 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
625                 630                 635                 640 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
                645                 650                 655     


Phe Cys Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr 
            660                 665                 670         


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
        675                 680                 685             


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
    690                 695                 700                 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
705                 710                 715                 720 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
                725                 730                 735     


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
            740                 745                 750         


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
        755                 760                 765             


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    770                 775                 780                 


<210>  123
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-prME

<400>  123

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu 
            20                  25                  30          


Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp 
        35                  40                  45              


Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys 
    50                  55                  60                  


Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser 
65                  70                  75                  80  


Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp 
                85                  90                  95      


Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His 
            100                 105                 110         


His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro 
        115                 120                 125             


Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu 
    130                 135                 140                 


Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe 
145                 150                 155                 160 


Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu 
                165                 170                 175     


Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu 
            180                 185                 190         


Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp 
        195                 200                 205             


Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu 
    210                 215                 220                 


His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp 
225                 230                 235                 240 


Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser 
                245                 250                 255     


Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys 
            260                 265                 270         


Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr 
        275                 280                 285             


Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
    290                 295                 300                 


Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser 
305                 310                 315                 320 


Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg 
                325                 330                 335     


Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn 
            340                 345                 350         


Asp Ile Gly His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr 
        355                 360                 365             


Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu 
    370                 375                 380                 


Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr 
385                 390                 395                 400 


Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe 
                405                 410                 415     


His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro 
            420                 425                 430         


His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala 
        435                 440                 445             


Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His 
    450                 455                 460                 


Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly 
465                 470                 475                 480 


Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu 
                485                 490                 495     


Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe 
            500                 505                 510         


Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val 
        515                 520                 525             


Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala 
    530                 535                 540                 


Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn 
545                 550                 555                 560 


Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu 
                565                 570                 575     


Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys 
            580                 585                 590         


Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala 
        595                 600                 605             


Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp 
    610                 615                 620                 


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly 
625                 630                 635                 640 


Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly 
                645                 650                 655     


Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp 
            660                 665                 670         


Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala 
        675                 680                 685             


Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
    690                 695                 700         


<210>  124
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-prME (construct 1)

<400>  124
atggactgga cctggattct gtttctggtc gctgctgcta caagagtgca ttctgggatt       60

attggactgc tgctgactac tgccatggca gcagagatca ccaggagagg cagcgcctac      120

tatatgtacc tggaccggtc tgatgccggc aaggccatca gctttgccac cacactgggc      180

gtgaataagt gccacgtgca gatcatggac ctgggccaca tgtgcgatgc caccatgtcc      240

tacgagtgtc caatgctgga cgagggcgtg gagcccgacg atgtggattg ctggtgtaac      300

accacatcta catgggtggt gtatggcacc tgtcaccaca agaagggaga ggcacggcgc      360

agcaggagag cagtgacact gccctctcac agcaccagga agctgcagac aagaagccag      420

acctggctgg agtcccggga gtatacaaag cacctgatca aggtggagaa ctggatcttt      480

cgcaatccag gattcgcact ggtggcagtg gcaatcgcat ggctgctggg cagctccacc      540

tcccagaaag tgatctacct ggtcatgatc ctgctgatcg cccctgccta ttccatcagg      600

tgcatcggcg tgtctaatag agacttcgtg gagggcatgt ctggcggcac ctgggtggat      660

gtggtgctgg agcacggcgg atgcgtgaca gtgatggccc aggacaagcc aaccgtggat      720

atcgagctgg tgaccacaac cgtgagcaac atggccgagg tgaggtccta ctgctatgag      780

gcctccatct ctgacatggc cagcgattcc agatgtccca cccagggcga ggcctacctg      840

gacaagcagt ccgatacaca gtacgtgtgc aagcggaccc tggtggacag gggatgggga      900

aatggatgtg gcctgtttgg caagggctct ctggtgacat gcgccaagtt cacctgttct      960

aagaagatga ccggcaagag catccagccc gagaacctgg agtacaggat catgctgagc     1020

gtgcacggca gccagcactc cggcatgaca gtgaacgaca tcggctatga gaccgatgag     1080

aatagggcca aggtggaggt gacacctaac agcccaagag ccgaggccac cctgggcggc     1140

tttggctccc tgggactgga ctgcgagcct agaacaggcc tggacttctc cgatctgtac     1200

tatctgacca tgaacaataa gcactggctg gtgcacaagg agtggtttca cgacatccca     1260

ctgccatggc acgcaggagc agatacagga accccacact ggaacaataa ggaggccctg     1320

gtggagttca aggatgccca cgccaagcgc cagacagtgg tggtgctggg cagccaggag     1380

ggagcagtgc acaccgccct ggcaggcgcc ctggaggccg agatggacgg cgccaagggc     1440

aagctgtttt ccggccacct gaagtgccgg ctgaagatgg ataagctgcg cctgaagggc     1500

gtgtcttaca gcctgtgcac agccgccttc accttcacca aggtgcctgc cgagaccctg     1560

cacggcacag tgaccgtgga ggtgcagtat gccggcacag acggcccctg taagatccct     1620

gtgcagatgg ccgtggatat gcagacactg acccctgtgg gccggctgat caccgcaaat     1680

ccagtgatca cagagtccac cgagaactct aagatgatgc tggagctgga ccctcccttc     1740

ggcgacagct acatcgtgat cggcgtgggc gacaagaaga tcacacacca ctggcaccgc     1800

tccggctcta caatcggcaa ggccttcgag gcaaccgtgc ggggcgccaa gaggatggcc     1860

gtgctgggcg acaccgcatg ggattttggc tccgtgggcg gcgtgttcaa ctctctgggc     1920

aagggcatcc accagatctt cggcgccgcc tttaagtctc tgttcggcgg aatgtcttgg     1980

ttcagccaga tcctgatcgg cacactgctg gtgtggctgg gcctgaacac caagaatggc     2040

agcatctctc tgacttgtct ggccctggga ggcgtgatga ttttcctgtc cactgccgtg     2100

tctgcctgat aa                                                         2112


<210>  125
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-prME (construct 1)

<400>  125

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu 
            20                  25                  30          


Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp 
        35                  40                  45              


Ala Gly Lys Ala Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys 
    50                  55                  60                  


His Val Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser 
65                  70                  75                  80  


Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp 
                85                  90                  95      


Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His 
            100                 105                 110         


His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro 
        115                 120                 125             


Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu 
    130                 135                 140                 


Ser Arg Glu Tyr Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe 
145                 150                 155                 160 


Arg Asn Pro Gly Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu 
                165                 170                 175     


Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu 
            180                 185                 190         


Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp 
        195                 200                 205             


Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu 
    210                 215                 220                 


His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp 
225                 230                 235                 240 


Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser 
                245                 250                 255     


Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys 
            260                 265                 270         


Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr 
        275                 280                 285             


Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
    290                 295                 300                 


Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser 
305                 310                 315                 320 


Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg 
                325                 330                 335     


Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly Met Thr Val Asn 
            340                 345                 350         


Asp Ile Gly Tyr Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr 
        355                 360                 365             


Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu 
    370                 375                 380                 


Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr 
385                 390                 395                 400 


Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe 
                405                 410                 415     


His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro 
            420                 425                 430         


His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala 
        435                 440                 445             


Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His 
    450                 455                 460                 


Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly 
465                 470                 475                 480 


Lys Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu 
                485                 490                 495     


Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe 
            500                 505                 510         


Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val 
        515                 520                 525             


Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala 
    530                 535                 540                 


Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn 
545                 550                 555                 560 


Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu 
                565                 570                 575     


Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys 
            580                 585                 590         


Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala 
        595                 600                 605             


Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp 
    610                 615                 620                 


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly 
625                 630                 635                 640 


Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly 
                645                 650                 655     


Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp 
            660                 665                 670         


Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala 
        675                 680                 685             


Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
    690                 695                 700         


<210>  126
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-NS1

<400>  126
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca tagcgtggga       60

tgcagcgtgg acttcagcaa gaaggagacc cgctgcggaa caggcgtgtt cgtgtacaac      120

gacgtggagg cttggagaga ccggtacaag taccaccccg atagccctag aagactggcc      180

gcagccgtga aacaggcttg ggaagaggga atttgcggca tcagcagcgt gtcccggatg      240

gagaacatca tgtggaagag cgtggagggc gagctgaacg ctatcctgga ggagaacggc      300

gtgcagctga cagtggtcgt gggatcagtg aagaacccca tgtggagagg ccctcagagg      360

ctgccagtgc cagtgaacga actgcctcac ggttggaagg cttggggcaa gagctacttc      420

gtgagggccg ccaagaccaa caacagcttc gtggtggacg gcgataccct caaggagtgt      480

cctctgaagc accgggcttg gaacagcttc ctggtggaag accacggctt tggcgtgttc      540

cacacaagcg tctggctgaa ggtccgcgaa gactacagcc tggagtgcga tccagcagtg      600

atcggcacag ccgtgaaggg aaaagaggcc gctcacagcg acctgggcta ttggatcgag      660

agcgagaaga acgacacttg gaggctgaag cgggcccacc tgatcgagat gaagacttgc      720

gagtggccca agagccacac tctgtggaca gacggcgtgg aagagagcga cctgatcatc      780

cctaagagcc tggccggacc tctgtctcat cacaacacca gggagggcta cagaacccag      840

gtgaagggac cttggcacag cgaagagctg gagatccgct tcgaggagtg tccaggaacc      900

aaggtgcacg tggaggagac ttgcggaacc agaggcccta gcctgagaag cacaacagcc      960

agcggacgcg tgatcgagga gtggtgttgt agggagtgca ccatgcctcc tctgagcttc     1020

agggccaagg acggttgttg gtacggcatg gagatcaggc ccagaaagga gccagagagc     1080

aacctcgtgc ggtctatggt gacagccgga agctgataa                            1119


<210>  127
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-NS1

<400>  127

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Gly Cys Ser Val Asp Phe Ser Lys Lys Glu Thr Arg Cys 
            20                  25                  30          


Gly Thr Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp Arg Asp Arg 
        35                  40                  45              


Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala Ala Val Lys 
    50                  55                  60                  


Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser Ser Val Ser Arg Met 
65                  70                  75                  80  


Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu Leu Asn Ala Ile Leu 
                85                  90                  95      


Glu Glu Asn Gly Val Gln Leu Thr Val Val Val Gly Ser Val Lys Asn 
            100                 105                 110         


Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val Pro Val Asn Glu Leu 
        115                 120                 125             


Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val Arg Ala Ala 
    130                 135                 140                 


Lys Thr Asn Asn Ser Phe Val Val Asp Gly Asp Thr Leu Lys Glu Cys 
145                 150                 155                 160 


Pro Leu Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu Asp His Gly 
                165                 170                 175     


Phe Gly Val Phe His Thr Ser Val Trp Leu Lys Val Arg Glu Asp Tyr 
            180                 185                 190         


Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val Lys Gly Lys 
        195                 200                 205             


Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile Glu Ser Glu Lys Asn 
    210                 215                 220                 


Asp Thr Trp Arg Leu Lys Arg Ala His Leu Ile Glu Met Lys Thr Cys 
225                 230                 235                 240 


Glu Trp Pro Lys Ser His Thr Leu Trp Thr Asp Gly Val Glu Glu Ser 
                245                 250                 255     


Asp Leu Ile Ile Pro Lys Ser Leu Ala Gly Pro Leu Ser His His Asn 
            260                 265                 270         


Thr Arg Glu Gly Tyr Arg Thr Gln Val Lys Gly Pro Trp His Ser Glu 
        275                 280                 285             


Glu Leu Glu Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val His Val 
    290                 295                 300                 


Glu Glu Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala 
305                 310                 315                 320 


Ser Gly Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro 
                325                 330                 335     


Pro Leu Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu Ile 
            340                 345                 350         


Arg Pro Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met Val Thr 
        355                 360                 365             


Ala Gly Ser 
    370     


<210>  128
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-capsid

<400>  128
atggactgga cttggatcct gtttctggtg gccgccgcca caagagtgca tagcaagaac       60

cccaagaaga agagcggcgg cttcaggatc gtgaacatgc tgaagcgggg cgtggctaga      120

gtgaaccctc tgggaggcgg actgaagaga ctgccagcag gactgctcct gggacacgga      180

cctattcgca tggtgctggc catcctggct ttcctgaggt tcaccgccat caagcccagc      240

ctgggactga tcaaccgctg gggttcagtc ggcaagaagg aggccatgga gatcatcaag      300

aagttcaaga aggacctggc cgccatgctg aggatcatca acgcccggaa ggagcggaag      360

agaagaggag ccgacaccag catcggcatc atcggactgc tgctgacaac cgccatggct      420

gccgagatct gatgatga                                                    438


<210>  129
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-capsid

<400>  129

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn 
            20                  25                  30          


Met Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Gly Leu 
        35                  40                  45              


Lys Arg Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met 
    50                  55                  60                  


Val Leu Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser 
65                  70                  75                  80  


Leu Gly Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met 
                85                  90                  95      


Glu Ile Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile 
            100                 105                 110         


Ile Asn Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile 
        115                 120                 125             


Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile 
    130                 135                 140             


<210>  130
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME MR766

<400>  130
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca ttcaggagcc       60

gacacctcta tcggcatcgt gggactgctg ctgaccacag ccatggccgc cgaaattacc      120

aggaggggca gcgcctacta catgtacctg gacagaagcg acgccggaaa agccatcagc      180

ttcgccacaa ccctgggcgt caacaagtgc cacgtgcaga tcatggacct gggccacatg      240

tgcgacgcca caatgagcta cgagtgccct atgctggacg agggagtgga accagacgac      300

gtcgactgtt ggtgcaacac cacctccact tgggtcgtgt acggcacttg ccaccacaag      360

aagggcgagg ccagaagaag cagaagagcc gtgaccctgc ctagccacag caccagaaag      420

ctgcagacca ggagccagac ttggctggaa agccgcgagt acaccaagca cctgatcaag      480

gtggagaatt ggatcttccg gaaccccggc ttcacactgg tggccgtggc aatcgcttgg      540

ctgctgggat ctagcaccag ccagaaagtg atctacctgg tcatgatcct gctgatcgcc      600

ccagcctaca gcatccgctg tatcggagtg agcaaccggg acttcgtgga gggaatgagc      660

ggaggaactt gggtggacgt ggtgctggaa cacggaggtt gcgtgacagt gatggctcag      720

gacaagccca ccgtggatat cgagctggtg accaccaccg tgtccaacat ggccgaagtg      780

cgcagctact gctacgaggc cagtatctcc gacatggcca gcgatagccg ctgtcctaca      840

cagggagagg cctatctgga caagcagagc gacacccagt acgtctgcaa gaggaccctc      900

gtggatagag gctggggaaa cggttgcgga ctgttcggaa agggcagcct cgtgacttgc      960

gccaagttca cttgcagcaa gaagatgacc ggcaagtcta tccagcccga gaacctggag     1020

taccggatca tgctgagcgt gcacggaagc cagcacagcg gcatgatcgt gaacgacgag     1080

ggatacgaga ccgacgagaa cagggccaag gtggaagtga cccctaacag ccctagagcc     1140

gaagccacac tgggaggatt tggcagcctg ggactggatt gcgagcctag aacaggcctg     1200

gacttcagcg acctgtacta cctgaccatg aacaacaagc attggctggt gcacaaggag     1260

tggttccacg acatccctct gccttggcac gcaggagccg atacaggcac acctcattgg     1320

aacaacaagg aggccctggt ggagttcaag gacgctcacg ccaagagaca gacagtggtg     1380

gtgctgggaa gccaggaagg agcagtgcat acagccctgg caggagctct ggaagcagaa     1440

atggacggcg ctaagggcag actgttcagc ggacacctca agtgccggct gaagatggac     1500

aagctgcggc tgaagggcgt gtcttacagc ctctgcaccg cagccttcac cttcaccaag     1560

gtgccagcag agacactgca cggaacagtg accgtggaag tgcagtacgc cggaacagac     1620

ggaccttgca aagtgccagc ccagatggca gtggacatgc agacactgac cccagtggga     1680

aggctgatca ccgctaaccc cgtcatcacc gagagcaccg agaacagcaa gatgatgctg     1740

gagctggacc cccccttcgg cgatagctac atcgtgatcg gcgtgggcga caagaagatc     1800

acccaccatt ggcacagaag cggcagcaca atcggcaagg ctttcgaggc caccgtgaga     1860

ggagctaaga gaatggccgt gctgggagac accgcttggg attttggcag cgtgggagga     1920

gtgttcaaca gcctgggcaa gggcatccac cagatcttcg gagccgcctt caagagcctg     1980

ttcggcggca tgtcttggtt cagccagatc ctgatcggaa cactcctcgt ctggctggga     2040

ctgaacacca agaacggcag catcagcctg acttgtctgg ccctgggagg cgtgatgatc     2100

ttcctgagca ccgccgtgtc cgcttgataa                                      2130


<210>  131
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME MR766

<400>  131

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Asp Thr Ser Ile Gly Ile Val Gly Leu Leu Leu Thr 
            20                  25                  30          


Thr Ala Met Ala Ala Glu Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
        35                  40                  45              


Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala Ile Ser Phe Ala Thr Thr 
    50                  55                  60                  


Leu Gly Val Asn Lys Cys His Val Gln Ile Met Asp Leu Gly His Met 
65                  70                  75                  80  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
                85                  90                  95      


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
            100                 105                 110         


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
        115                 120                 125             


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
    130                 135                 140                 


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Lys 
145                 150                 155                 160 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Thr Leu Val Ala Val 
                165                 170                 175     


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
            180                 185                 190         


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
        195                 200                 205             


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
    210                 215                 220                 


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
225                 230                 235                 240 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
                245                 250                 255     


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
            260                 265                 270         


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
        275                 280                 285             


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
    290                 295                 300                 


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys 
305                 310                 315                 320 


Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
                325                 330                 335     


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
            340                 345                 350         


Ser Gly Met Ile Val Asn Asp Glu Gly Tyr Glu Thr Asp Glu Asn Arg 
        355                 360                 365             


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
    370                 375                 380                 


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
385                 390                 395                 400 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
                405                 410                 415     


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
            420                 425                 430         


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
        435                 440                 445             


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
    450                 455                 460                 


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
465                 470                 475                 480 


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
                485                 490                 495     


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
            500                 505                 510         


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
        515                 520                 525             


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
    530                 535                 540                 


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
545                 550                 555                 560 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
                565                 570                 575     


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
            580                 585                 590         


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly 
        595                 600                 605             


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
    610                 615                 620                 


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
625                 630                 635                 640 


Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
                645                 650                 655     


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
            660                 665                 670         


Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
        675                 680                 685             


Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr 
    690                 695                 700                 


Ala Val Ser Ala 
705             


<210>  132
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME Brazil

<400>  132
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca ttcaggagcc       60

gacacatcag tgggcatcgt gggactgctg ctgacaacag ctatggccgc cgaagtgacc      120

agaagaggca gcgcctacta catgtacctg gaccggaacg acgccggaga ggccattagc      180

tttcctacca ccctgggcat gaacaagtgc tacatccaga tcatggacct gggccacatg      240

tgcgacgcta caatgagcta cgagtgcccc atgctggacg aaggagtgga gccagacgac      300

gtggattgtt ggtgcaacac cacctccact tgggtcgtgt acggcacctg tcaccacaaa      360

aagggcgaag ccaggagaag cagaagagcc gtgaccctgc ctagccactc taccaggaag      420

ctgcagacca ggagccagac ttggctggag agcagggagt acaccaagca cctgatccgc      480

gtggagaatt ggatcttcag aaaccccggc ttcgccctgg cagccgcagc aattgcttgg      540

ctgctgggat ctagcaccag ccagaaggtc atctacctgg tcatgatcct gctgatcgcc      600

cccgcttaca gcatccgctg tatcggcgtg tccaacaggg acttcgtgga gggcatgagc      660

ggaggaactt gggtggacgt ggtgctggaa cacggaggtt gtgtgaccgt gatggctcag      720

gacaagccta ccgtggacat cgagctggtg accacaaccg tgtccaacat ggccgaggtc      780

cgcagctatt gctacgaggc cagcatcagc gatatggcca gcgatagcag gtgtcccacc      840

cagggtgaag cttacctgga caagcagagc gacacccagt acgtgtgcaa gcggacactg      900

gtggatagag gctggggaaa cggttgcggc ctgtttggca agggaagcct ggtgacctgc      960

gccaagttcg catgcagcaa gaagatgacc ggcaagagca tccagcccga gaacctggag     1020

taccggatca tgctgagcgt gcacggatct cagcatagcg gaatgatcgt gaacgacacc     1080

ggccacgaga ccgacgaaaa cagggccaag gtggaaatca cccccaactc tcctagagcc     1140

gaggccacac tgggaggttt tggaagcctg ggcctggatt gcgagcctag aacaggcctg     1200

gacttcagcg acctgtacta cctgaccatg aacaacaagc attggctggt gcacaaggag     1260

tggttccacg acatccctct gccttggcac gcaggagcag atacaggaac cccccattgg     1320

aacaacaagg aggccctggt ggagttcaag gacgctcacg ccaagagaca gacagtggtg     1380

gtgctgggaa gccaggaagg agcagtgcac acagctctgg caggagctct ggaagccgaa     1440

atggacggag ccaagggcag actgtcctcc ggacacctca agtgccggct gaagatggac     1500

aagctgcggc tgaagggcgt gtcttatagc ctctgcacag ccgctttcac cttcaccaag     1560

atccccgcag agaccctgca cggaacagtg accgtggaag tgcagtacgc cggaacagac     1620

ggaccttgca aggtgccagc tcagatggca gtggacatgc agaccctgac cccagtggga     1680

agactgatca ccgctaaccc cgtcatcacc gagagcaccg agaacagcaa gatgatgctg     1740

gagctggacc cccccttcgg cgatagctac atcgtgatcg gcgtgggcga gaaaaagatc     1800

acccaccatt ggcacaggag cggcagcaca atcggcaagg cctttgaggc caccgtgaga     1860

ggagccaaga gaatggccgt gctgggagat accgcttggg atttcggcag cgtgggaggc     1920

gccctgaaca gcctgggcaa gggcattcac cagatcttcg gagccgcctt caagagcctg     1980

ttcggcggca tgtcttggtt cagccagatc ctgatcggca cactgctcat gtggctgggc     2040

ctgaacacca agaacggcag catcagcctg atgtgtctgg ctctgggagg cgtgctgatc     2100

ttcctgagca ccgctgtgtc cgcttgataa                                      2130


<210>  133
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME Brazil

<400>  133

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr 
            20                  25                  30          


Thr Ala Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
        35                  40                  45              


Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr 
    50                  55                  60                  


Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met 
65                  70                  75                  80  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
                85                  90                  95      


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
            100                 105                 110         


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
        115                 120                 125             


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
    130                 135                 140                 


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg 
145                 150                 155                 160 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala 
                165                 170                 175     


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
            180                 185                 190         


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
        195                 200                 205             


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
    210                 215                 220                 


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
225                 230                 235                 240 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
                245                 250                 255     


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
            260                 265                 270         


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
        275                 280                 285             


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
    290                 295                 300                 


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys 
305                 310                 315                 320 


Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
                325                 330                 335     


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
            340                 345                 350         


Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg 
        355                 360                 365             


Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
    370                 375                 380                 


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
385                 390                 395                 400 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
                405                 410                 415     


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
            420                 425                 430         


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
        435                 440                 445             


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
    450                 455                 460                 


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
465                 470                 475                 480 


Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg 
                485                 490                 495     


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
            500                 505                 510         


Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly 
        515                 520                 525             


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
    530                 535                 540                 


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
545                 550                 555                 560 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
                565                 570                 575     


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
            580                 585                 590         


Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser Gly 
        595                 600                 605             


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
    610                 615                 620                 


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
625                 630                 635                 640 


Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
                645                 650                 655     


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
            660                 665                 670         


Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
        675                 680                 685             


Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile Phe Leu Ser Thr 
    690                 695                 700                 


Ala Val Ser Ala 
705             


<210>  134
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader

<400>  134

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  135
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-2G4

<400>  135

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Met Gln 
            20                  25                  30          


Pro Gly Gly Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His 
65                  70                  75                  80  


Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Arg Ser Val Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Gly Ile Tyr Tyr Cys Thr Arg Gly Asn Gly Asn Tyr Arg Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly 
465                 470                 475                 480 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                485                 490                 495     


Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu 
            500                 505                 510         


Trp Ile Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ala 
        515                 520                 525             


Ser Leu Ser Val Ser Val Gly Glu Thr Val Ser Ile Thr Cys Arg Ala 
    530                 535                 540                 


Ser Glu Asn Ile Tyr Ser Ser Leu Ala Trp Tyr Gln Gln Lys Gln Gly 
545                 550                 555                 560 


Lys Ser Pro Gln Leu Leu Val Tyr Ser Ala Thr Ile Leu Ala Asp Gly 
                565                 570                 575     


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser Leu 
            580                 585                 590         


Lys Ile Asn Ser Leu Gln Ser Glu Asp Phe Gly Thr Tyr Tyr Cys Gln 
        595                 600                 605             


His Phe Trp Gly Thr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
    610                 615                 620                 


Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  136
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGX9226, DMAb-2G4

<400>  136
atggattgga catggaggat tctgtttctg gtcgccgccg caactggaac ccacgctgaa       60

gtgcagctgc aggagtcagg aggaggactg atgcagcccg gcggaagcat gaagctgtcc      120

tgcgtggcat ctggcttcac ctttagtaac tactggatga attgggtccg ccagtcacct      180

gagaagggac tggaatgggt ggctgagatc cgactgaaaa gcaacaatta cgccacccac      240

tatgctgagt cagtgaaggg gcgattcaca attagcaggg acgattctaa aagaagtgtg      300

tatctgcaga tgaacactct gagagccgaa gacaccggaa tctactattg cacacggggc      360

aacggaaatt accgcgctat ggattattgg gggcagggca cttccgtcac cgtgagctcc      420

gcaagcacaa agggaccctc cgtgtttccc ctggcccctt ctagtaaaag cacctccgga      480

ggaacagcag ctctgggatg tctggtgaag gactacttcc ctgagccagt caccgtgtca      540

tggaacagcg gagccctgac ctctggggtc catacatttc ctgctgtgct gcagtcaagc      600

gggctgtact ccctgtcctc tgtggtcact gtgccaagtt caagcctggg cactcagacc      660

tatatctgca acgtgaatca caagcccagc aataccaaag tcgacaagaa agtggagcct      720

aagtcctgtg ataaaacaca tacttgccca ccttgtccag cacctgaact gctgggagga      780

cctagcgtgt tcctgtttcc acccaagcca aaagacacac tgatgatttc ccgcactcct      840

gaggtcacct gtgtggtcgt ggacgtgtct cacgaggacc ccgaagtcaa gttcaactgg      900

tacgtggatg gcgtcgaagt gcataatgcc aagaccaaac ccagggagga acagtacaac      960

tctacctata gggtcgtgag tgtcctgaca gtgctgcacc aggactggct gaacggcaag     1020

gagtataagt gcaaagtgag caataaggct ctgccagcac ccatcgaaaa aactatttcc     1080

aaggccaaag gacagccaag agagccccag gtgtacaccc tgcctccatc tcgggacgaa     1140

ctgacaaaga accaggtcag tctgacttgt ctggtgaaag gcttctatcc atccgatatc     1200

gctgtggagt gggaatctaa tggacagccc gagaacaatt acaagaccac accccctgtg     1260

ctggactccg atgggtcttt ctttctgtat agtaagctga ccgtggataa atcacggtgg     1320

cagcagggca acgtcttttc ttgcagtgtg atgcatgaag ccctgcacaa tcattacaca     1380

cagaagtcac tgagcctgtc cccaggcaag cgaggacgaa aaaggagatc tggaagtggg     1440

gctactaact tcagcctgct gaaacaggca ggcgacgtgg aggaaaatcc tggaccaatg     1500

gtcctgcaga cccaggtgtt tatctcactg ctgctgtgga ttagcggggc ttacggcgat     1560

attcagatga cacagtcccc agcatcactg agcgtctccg tgggagaaac agtgtccatc     1620

acttgtcgcg cctctgagaa catctacagc agcctggctt ggtatcagca gaagcaggga     1680

aaaagccccc agctgctggt ctactccgca acaatcctgg ccgacggggt gccttctagg     1740

ttctctggca gtggatcagg gacacagtat agcctgaaga ttaatagtct gcagtcagag     1800

gattttggga cttactattg ccagcacttc tggggcacac catacacttt tggcggaggg     1860

actaagctgg agatcaaaac cgtcgcagcc ccctctgtgt tcatttttcc acccagtgac     1920

gaacagctga agagtggcac cgcctcagtc gtgtgtctgc tgaacaattt ctaccctaga     1980

gaggcaaagg tccagtggaa agtggataac gccctgcaga gcggcaattc ccaggaatct     2040

gtgactgagc aggacagtaa ggattcaacc tatagcctgt ccaacaccct gacactgagc     2100

aaagctgact acgaaaagca caaagtctat gcatgcgagg tgacacatca gggactgagt     2160

tcaccagtga ctaagtcctt taatcggggg gagtgttgat aa                        2202


<210>  137
<211>  711
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-4G7

<400>  137

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr Gly Phe 
            20                  25                  30          


Ser Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Thr Tyr Tyr Gly Gly Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Tyr Tyr Gly Ser Thr Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
465                 470                 475                 480 


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
                485                 490                 495     


Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser 
            500                 505                 510         


Val Gly Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr 
        515                 520                 525             


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu 
    530                 535                 540                 


Leu Val Tyr Asn Ala Lys Thr Leu Ile Glu Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu 
                565                 570                 575     


Gln Pro Glu Asp Phe Gly Ser Tyr Phe Cys Gln His His Phe Gly Thr 
            580                 585                 590         


Pro Phe Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile Lys Thr Val Ala 
        595                 600                 605             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    610                 615                 620                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
625                 630                 635                 640 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                645                 650                 655     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            660                 665                 670         


Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        675                 680                 685             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    690                 695                 700                 


Ser Phe Asn Arg Gly Glu Cys 
705                 710     


<210>  138
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9229, DMAb-4G7

<400>  138
atggattgga catggaggat tctgtttctg gtcgccgccg ccactggaac ccacgcccag       60

gtgcagctgc agcagtcagg gcctgagctg gaaatgcctg gcgcttctgt gaaaatcagt      120

tgcaaggcat caggaagctc cttcacaggg tttagcatga actgggtgaa acagagcaat      180

gggaagtccc tggagtggat cggcaacatt gacacctact atggcggaac cacatacaat      240

cagaagttca aaggcaaggc tacactgact gtggacaaat ctagttcaac cgcatatatg      300

cagctgaaga gcctgacatc cgaggattct gcagtgtact attgcgctag atcagcatac      360

tatggcagca ctttcgccta ctggggccag ggaaccctgg tcacagtgag ctccgcctcc      420

accaaaggac catctgtgtt tcccctggct ccttctagta agagtacatc aggaggaact      480

gcagctctgg gatgtctggt gaaggattat ttccctgagc cagtcaccgt gagttggaac      540

tcaggcgcac tgacttctgg agtccacacc tttcctgccg tgctgcagtc aagcggcctg      600

tacagcctgt cctctgtggt caccgtgcca agttcaagcc tgggaaccca gacatatatc      660

tgcaacgtga atcacaaacc ctctaataca aaggtcgaca agaaagtgga acctaaaagc      720

tgtgataaga ctcatacctg cccaccttgt ccagcacctg agctgctggg agggccttcc      780

gtgttcctgt ttccacccaa accaaaggac acactgatga ttagcagaac ccctgaagtc      840

acatgtgtgg tcgtggacgt gtcccacgag gaccccgaag tcaagttcaa ctggtacgtg      900

gatggcgtcg aggtgcataa tgctaaaacc aagccccgag aggaacagta caactctact      960

tatagggtcg tgagtgtcct gaccgtgctg caccaggact ggctgaacgg caaggagtat     1020

aaatgcaagg tgtctaacaa ggccctgcca gctcccatcg agaagacaat tagcaaagct     1080

aagggacagc caagagaacc ccaggtgtac actctgcctc catctcggga cgagctgacc     1140

aaaaaccagg tcagtctgac atgtctggtg aagggattct atccaagcga tatcgcagtg     1200

gagtgggaat ccaatgggca gcccgaaaac aattacaaga ctaccccccc tgtgctggac     1260

agcgatggca gcttcttcct gtattccaaa ctgacagtgg ataagtctcg gtggcagcag     1320

gggaacgtct ttagctgctc cgtgatgcat gaggccctgc acaatcatta cactcagaag     1380

tctctgagtc tgtcaccagg caaacgagga cgaaagagga gaagcgggtc cggagcaacc     1440

aacttctccc tgctgaagca ggctggagac gtggaggaaa atcctgggcc aatggtcctg     1500

cagacacagg tgtttatctc actgctgctg tggattagcg gggcctacgg cgatattcag     1560

atgactcaga gccccgcatc tctgagtgcc tcagtcggcg agacagtgac tatcacctgt     1620

cgcgcaagtg aaaacatcta ctcatatctg gcctggtacc agcagaaaca ggggaagagc     1680

ccccagctgc tggtctataa tgctaaaacc ctgatcgaag gagtgccttc ccgattcagc     1740

ggcagcgggt ctggcacaca gtttagcctg aagattaact ccctgcagcc agaggacttc     1800

ggcagctact tttgccagca ccatttcgga actcccttca cctttggcag cgggacagag     1860

ctggaaatca aaactgtcgc agcccccagt gtgttcattt ttccaccctc agacgaacag     1920

ctgaagtctg ggaccgccag tgtcgtgtgt ctgctgaaca atttttaccc tcgggaggct     1980

aaagtccagt ggaaggtgga taacgcactg cagtctggaa atagtcagga gtcagtgaca     2040

gaacaggaca gcaaagattc cacttatagt ctgtcaaaca cactgactct gtctaaggcc     2100

gactacgaga aacacaaggt ctatgcttgc gaagtgactc atcaggggct gtcctctcct     2160

gtgaccaaga gcttcaatcg cggcgagtgt tgataa                               2196


<210>  139
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAB4

<400>  139

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Leu Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Ser Gly Val Gly Val Gly Trp Phe Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala Leu Ile Trp Trp Asp Asp Asp Lys Tyr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Lys Ser Gln Leu Ser Ile Ser Lys Asp Phe Ser Arg 
                85                  90                  95      


Asn Gln Val Phe Leu Lys Ile Ser Asn Val Asp Ile Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Arg Asp Pro Phe Gly Tyr Asp Asn Ala Met 
        115                 120                 125             


Gly Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser 
465                 470                 475                 480 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                485                 490                 495     


Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu 
            500                 505                 510         


Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Gln 
        515                 520                 525             


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Ser Leu Thr Cys Lys 
    530                 535                 540                 


Ala Ser Gln Asn Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
545                 550                 555                 560 


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Arg Tyr Thr 
                565                 570                 575     


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
            580                 585                 590         


Leu Thr Ile Ser Asn Met Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys 
        595                 600                 605             


Gln Gln Tyr Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
    610                 615                 620                 


Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
625                 630                 635                 640 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
                645                 650                 655     


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
            660                 665                 670         


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
        675                 680                 685             


Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp 
    690                 695                 700                 


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
705                 710                 715                 720 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730             


<210>  140
<211>  2226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9230, DMAb4

<400>  140
ggatccgccg ccaccatgga ctggacttgg agaattctgt tcctggtcgc agcagccact       60

gggacacacg cacaggtgac actgaaagag agcggacccg gaatcctgaa accaagccag      120

actctgtccc tgacctgcag cctgtccggc ttctctctga gtacctcagg agtcggagtg      180

ggatggtttc gacagccaag cggaaaggga ctggagtggc tggccctgat ctggtgggac      240

gatgacaagt actataaccc ttcactgaaa agccagctga gcatttccaa ggatttctct      300

cgcaaccagg tctttctgaa gatcagtaat gtggatattg ccgacactgc tacctactat      360

tgcgctagga gagatccatt cggctacgac aatgcaatgg gatattgggg ccagggaacc      420

tccgtcacag tgagctccgc atccacaaaa gggccctctg tgtttcccct ggccccttct      480

agtaagtcta caagtggcgg aactgccgct ctgggctgtc tggtgaagga ctacttccct      540

gagccagtca ccgtgtcctg gaactctgga gccctgactt ctggggtcca cacctttcct      600

gctgtgctgc agtcaagcgg actgtacagc ctgtcctctg tggtcaccgt gccaagttca      660

agcctgggga cacagactta tatctgcaac gtgaatcaca agccatctaa tacaaaagtc      720

gataagaaag tggaacccaa gagctgtgac aaaacccata catgcccacc ttgtccagca      780

cctgagctgc tgggaggacc aagcgtgttc ctgtttccac ccaagcctaa agatacactg      840

atgatttcca ggacccccga agtgacatgt gtggtcgtgg atgtgtctca cgaggaccct      900

gaagtcaagt tcaactggta cgtggacggc gtcgaggtgc ataatgctaa gaccaaacct      960

cgcgaggaac agtacaacag tacatatcga gtcgtgtcag tgctgaccgt cctgcaccag     1020

gactggctga acggaaagga gtataagtgc aaagtgagca acaaggcact gccagccccc     1080

atcgagaaga ctatttccaa ggcaaaaggg cagccaaggg aaccccaggt gtacaccctg     1140

cctccaagca gagatgagct gactaaaaac caggtctccc tgacctgtct ggtgaagggg     1200

ttctatccta gtgacatcgc tgtggagtgg gaatcaaatg gccagccaga aaacaattac     1260

aagaccacac cccctgtgct ggatagtgac ggctcattct ttctgtattc aaagctgacc     1320

gtggataaaa gcagatggca gcagggaaac gtcttctcat gcagcgtgat gcatgaggcc     1380

ctgcacaatc attacactca gaaatccctg tctctgagtc ccggcaagcg aggaaggaaa     1440

cggcgctcag ggagcggcgc tacaaacttt tccctgctga agcaggcagg ggacgtggag     1500

gaaaatcctg gcccaatggt cctgcagacc caggtgttca tcagcctgct gctgtggatt     1560

tccggggcct acggcgatat tgtgatgacc cagagccaga agttcatgtc cacatctgtc     1620

ggcgaccggg tgtctctgac ctgtaaggcc agtcagaacg tcggaactgc tgtggcatgg     1680

tatcagcaga agcctgggca gtccccaaaa ctgctgatct acagtgcttc aaacagatat     1740

accggcgtgc ctgatcggtt caccggaagc gggtccggca cagactttac tctgaccatt     1800

tctaatatgc agagtgaaga tctggctgac tacttctgcc agcagtactc ctcttatcca     1860

ctgacatttg gagcagggac taagctggaa atcaaaacag tcgcagcccc ctccgtgttc     1920

atttttccac cctctgatga gcagctgaag tcaggcactg ccagcgtcgt gtgtctgctg     1980

aacaatttct accccaggga ggccaaggtc cagtggaaag tggacaacgc tctgcagagc     2040

ggaaattccc aggagtctgt gactgaacag gatagtaaag actcaaccta ttctctgagt     2100

aacacactga ctctgtccaa ggcagactac gagaagcaca aagtctatgc ctgcgaagtg     2160

acccatcagg gcctgagttc accagtgaca aagtctttta atcgcggaga gtgttgataa     2220

ctcgag                                                                2226


<210>  141
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-10

<400>  141

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Arg Ser Tyr Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Gly Thr Ala Gly Asp Thr Tyr Tyr Pro Gly 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Val Arg Phe Gly Asp Thr Ala Val Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
            500                 505                 510         


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
        515                 520                 525             


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
    530                 535                 540                 


Ile Ser Ser Phe Leu Asn Trp His Gln Gln Lys Pro Gly Lys Ala Pro 
545                 550                 555                 560 


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            580                 585                 590         


Ser Leu Gln Pro Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr 
        595                 600                 605             


Ile Ser Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Thr 
    610                 615                 620                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
625                 630                 635                 640 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                645                 650                 655     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            660                 665                 670         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        675                 680                 685             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    690                 695                 700                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
705                 710                 715                 720 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 


<210>  142
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9244, DMAb-10

<400>  142
ggatccgccg ccaccatgga ctggacttgg agaatcctgt tcctggtcgc cgccgctact       60

gggactcatg ccgaggtgca gctggtcgaa tctggagggg gcctggtgca gcctggcggc      120

agcctgaggc tgtcctgcgc agcatctggc ttcaccttta ggagctacga catgcactgg      180

gtgcgccagg caacaggcaa gggactggag tgggtgtctg ccatcggaac cgcaggcgat      240

acatactatc caggctccgt gaagggcagg ttcaccatct cccgcgagaa cgccaagaat      300

tctctgtacc tgcagatgaa cagcctgaga gccgaggaca ccgccgtgta ctattgcgcc      360

agggtgcgct tcggcgacac agcagtggat tattggggcc agggcaccct ggtgacagtg      420

agctccgcct ccaccaaggg accaagcgtg ttcccactgg caccttctag caagtccacc      480

tctggcggca cagccgccct gggctgtctg gtgaaggatt acttccctga gccagtgaca      540

gtgtcctgga actctggcgc cctgaccagc ggagtgcaca catttcctgc cgtgctgcag      600

tcctctggcc tgtactccct gagctccgtg gtgaccgtgc catctagctc cctgggcacc      660

cagacatata tctgcaacgt gaatcacaag cctagcaata caaaggtgga caagaaggtg      720

gagccaaagt cctgtgataa gacccacaca tgccctccct gtccagcacc tgagctgctg      780

ggcggcccaa gcgtgttcct gtttccaccc aagcccaagg acaccctgat gatcagccgg      840

accccagagg tgacatgcgt ggtggtggac gtgtcccacg aggaccccga ggtgaagttt      900

aactggtacg tggatggcgt ggaggtgcac aatgccaaga ccaagccccg ggaggagcag      960

tacaacagca cctatagagt ggtgtccgtg ctgacagtgc tgcaccagga ctggctgaac     1020

ggcaaggagt ataagtgcaa ggtgagcaat aaggccctgc cagcccccat cgagaagacc     1080

atctccaagg caaagggaca gccaagggag ccacaggtgt acacactgcc tccatcccgc     1140

gacgagctga ccaagaacca ggtgtctctg acatgtctgg tgaagggctt ctatccctct     1200

gatatcgccg tggagtggga gagcaatggc cagcctgaga acaattacaa gaccacaccc     1260

cctgtgctgg acagcgatgg ctccttcttt ctgtattcca agctgaccgt ggacaagtct     1320

cggtggcagc agggcaacgt gtttagctgc tccgtgatgc acgaggccct gcacaatcac     1380

tacacccaga agtctctgag cctgtcccca ggcaagaggg gaagaaagcg gagatctggc     1440

agcggcgcca caaacttcag cctgctgaag caggccggcg atgtggagga gaatcctggc     1500

ccaatggtgc tgcagaccca ggtgtttatc tctctgctgc tgtggatcag cggcgcctat     1560

ggcgacatcc agatgacaca gtccccttct agcctgtccg cctctgtggg cgatcgggtg     1620

accatcacat gtagagccag ccagtccatc tcctctttcc tgaactggca ccagcagaag     1680

cctggcaagg ccccaaagct gctgatctac gcagccagct ccctgcagag cggagtgccc     1740

tccaggttct ctggcagcgg ctccggaacc gactttaccc tgacaatctc tagcctgcag     1800

cctgaggatt ttgccatcta ctattgccag cagtcttata tcagcccctt cacctttggc     1860

cctggcacaa aggtggacat caagaccgtg gccgccccaa gcgtgttcat ctttccaccc     1920

tccgatgagc agctgaagtc tggcacagcc agcgtggtgt gcctgctgaa caatttctac     1980

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caattctcag     2040

gagagcgtga ccgagcagga ctccaaggat tctacatatt ctctgagctc taccctgaca     2100

ctgagcaagg ccgattacga gaagcacaag gtgtatgcct gcgaggtcac ccaccagggg     2160

ctgtcaagtc cagtcactaa gtccttcaat cggggcgaat gctgataact cgag           2214


<210>  143
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb-11

<400>  143

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Val 
        35                  40                  45              


Arg Ser Asn Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Leu Ile Tyr Ser Gly Gly Leu Thr Ala Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Val Ala Ser Ser Ala Gly Thr Phe Tyr Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser 
465                 470                 475                 480 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                485                 490                 495     


Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu 
            500                 505                 510         


Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro 
        515                 520                 525             


Arg Ser Leu Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg 
    530                 535                 540                 


Ser Ser Gln Ser Leu Leu His Arg Asn Gly Tyr Asn Tyr Leu Asp Trp 
545                 550                 555                 560 


Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly 
                565                 570                 575     


Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser 
            580                 585                 590         


Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val 
        595                 600                 605             


Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Ser Trp Thr Phe 
    610                 615                 620                 


Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro Ser Val 
625                 630                 635                 640 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
                645                 650                 655     


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
            660                 665                 670         


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
        675                 680                 685             


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
    690                 695                 700                 


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
705                 710                 715                 720 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
                725                 730                 735     


Gly Glu Cys 
            


<210>  144
<211>  2244
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9256, DMAb-11

<400>  144
ggatccgccg ccaccatgga ctggacctgg agaatcctgt tcctggtggc agcagcaacc       60

ggaacacacg cagaggtgca gctggtggag agcggcggcg gcctgatcca gccaggcggc      120

agcctgaggc tgtcctgcgc agcatctgga tttgccgtga ggagcaacta cctgtcctgg      180

gtgagacagg caccaggcaa gggactggag tgggtgtctc tgatctacag cggcggcctg      240

accgcatatg cagacagcgt ggagggcagg ttcaccatct ccagagataa ctctaagaat      300

acactgtatc tgcagatgaa ttccctgcgg gtggaggaca ccgccctgta ctattgcgcc      360

cgcgtggcca gctccgccgg cacattctac tatggcatgg acgtgtgggg ccagggcacc      420

acagtgaccg tgtctagcgc ctccacaaag ggaccaagcg tgttcccact ggcaccttcc      480

tctaagtcca cctctggcgg cacagccgcc ctgggctgtc tggtgaagga ttacttccct      540

gagccagtga ccgtgtcttg gaacagcggc gccctgacca gcggagtgca cacatttcct      600

gccgtgctgc agagctccgg cctgtactcc ctgtctagcg tggtgaccgt gccatcctct      660

agcctgggca cccagacata tatctgcaac gtgaatcaca agcctagcaa tacaaaggtg      720

gacaagaagg tggagccaaa gtcctgtgat aagacccaca catgccctcc ctgtccagca      780

cctgagctgc tgggcggccc aagcgtgttc ctgtttccac ccaagcccaa ggacacactg      840

atgatctcta ggaccccaga ggtgacatgc gtggtggtgg acgtgagcca cgaggacccc      900

gaggtgaagt ttaactggta cgtggatggc gtggaggtgc acaatgccaa gaccaagcca      960

agggaggagc agtacaacag cacctataga gtggtgtccg tgctgacagt gctgcaccag     1020

gactggctga acggcaagga gtataagtgc aaggtgtcca ataaggccct gccagccccc     1080

atcgagaaga ccatctctaa ggcaaaggga cagccaaggg agccacaggt gtacacactg     1140

cctccatcca gagacgagct gaccaagaac caggtgtctc tgacatgtct ggtgaagggc     1200

ttctatccct ctgatatcgc cgtggagtgg gagagcaatg gccagcctga gaacaattac     1260

aagaccacac cccctgtgct ggactccgat ggctctttct ttctgtattc caagctgacc     1320

gtggataagt ctcggtggca gcagggcaac gtgtttagct gctccgtgat gcacgaggcc     1380

ctgcacaatc actacaccca gaagtctctg agcctgtccc ctggcaagag gggaaggaag     1440

aggagatctg gcagcggcgc cacaaacttc agcctgctga agcaggcagg cgacgtggag     1500

gagaatcctg gaccaatggt gctgcagacc caggtgttta tctctctgct gctgtggatc     1560

agcggcgcct acggcgatat cgtgatgacc cagtcccctc gctccctgtc tgtgacacct     1620

ggcgagccag ccagcatctc ctgtcggtcc tctcagtctc tgctgcaccg caacggctac     1680

aattatctgg actggtacct gcagaagccc ggccagtccc ctcagctgct gatctatctg     1740

ggcagcaaca gggcatccgg agtgccagac cgcttctctg gcagcggctc cggaaccgac     1800

ttcaccctga agatcagcag ggtggaggcc gaggatgtgg gcgtgtacta ttgcatgcag     1860

gccctgcaga ccccctcctg gacattcggc cagggcacca aggtggagat caagacagtg     1920

gccgccccta gcgtgttcat ctttccaccc tccgacgagc agctgaagtc tggcaccgcc     1980

agcgtggtgt gcctgctgaa caacttctac cccagagagg ccaaggtgca gtggaaggtg     2040

gataacgccc tgcagagcgg caattcccag gagtctgtga ccgagcagga cagcaaggat     2100

tccacatatt ctctgagctc caccctgaca ctgagcaagg ccgactacga gaagcacaag     2160

gtgtatgcct gcgaggtgac ccaccagggc ctgtctagcc ctgtgacaaa gtccttcaac     2220

agaggcgagt gttgataact cgag                                            2244


<210>  145
<211>  741
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb12

<400>  145

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ala Thr Phe 
        35                  40                  45              


Gly Ser Asp Thr Val Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Met Gly Gly Ile Ile Pro Phe Phe Gly Glu Ala Asn Tyr Ala 
65                  70                  75                  80  


Gln Arg Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Gln Ile Asn Glu Met Ala Thr Phe Gly Glu Ile 
        115                 120                 125             


His Tyr Tyr Thr Tyr Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg 
465                 470                 475                 480 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
            500                 505                 510         


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Gly Ser 
        515                 520                 525             


Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val 
    530                 535                 540                 


Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Tyr Tyr Ala Ser Trp 
545                 550                 555                 560 


Tyr Gln Gln Lys Pro Arg Gln Ala Pro Val Leu Val Phe Tyr Gly Lys 
                565                 570                 575     


Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser 
            580                 585                 590         


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Ala Gln Ala Glu Asp Glu 
        595                 600                 605             


Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Ser Asn His Leu Val 
    610                 615                 620                 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ser Thr Val Ala Ala Pro 
625                 630                 635                 640 


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
                645                 650                 655     


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
            660                 665                 670         


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
        675                 680                 685             


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn 
    690                 695                 700                 


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
705                 710                 715                 720 


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
                725                 730                 735     


Asn Arg Gly Glu Cys 
            740     


<210>  146
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9260, DMAb12

<400>  146
catggactgg acctggagaa tcctgttcct ggtggcagca gcaaccggaa cacacgcaca       60

ggtgcagctg gtgcagagcg gagcagaggt gaagaagcca ggcagctccg tgaaggtgtc      120

ctgcaaggca tctggagcca ccttcggctc cgataccgtg acatgggtgc gccaggcacc      180

aggacaggga ctggagtgga tgggcggcat catccctttc tttggcgagg ccaactacgc      240

ccagcggttt cagggcagag tgaccatcac agccgacaag tccaccaata cagcctacat      300

ggagctgtct agcctgcggt ctgaggatac cgccgtgtat ttctgcgcca gacagatcaa      360

cgagatggcc acctttggcg agatccacta ctatacatac atggacgtgt ggggacaggg      420

caccctggtg acagtgtcct ctgcctccac caagggacct agcgtgttcc cactggcacc      480

tagctccaag tctaccagcg gcggcacagc cgccctggga tgtctggtga aggattattt      540

ccctgagcca gtgacagtgt cctggaactc tggcgccctg accagcggag tgcacacatt      600

tcccgccgtg ctgcagtcta gcggcctgta ctccctgtcc tctgtggtga ccgtgcctag      660

ctcctctctg ggcacccaga catatatctg caacgtgaat cacaagcctt ctaatacaaa      720

ggtggacaag aaggtggagc caaagagctg tgataagacc cacacatgcc ctccctgtcc      780

agcacctgag ctgctgggcg gcccaagcgt gttcctgttt ccacccaagc ccaaggacac      840

cctgatgatc agcaggaccc ctgaggtgac atgcgtggtg gtggacgtgt cccacgagga      900

ccccgaggtg aagttcaact ggtacgtgga tggcgtggag gtgcacaatg ccaagaccaa      960

gccccgggag gagcagtaca acagcaccta tagagtggtg tccgtgctga cagtgctgca     1020

ccaggactgg ctgaacggca aggagtataa gtgcaaggtg tctaataagg ccctgccagc     1080

ccccatcgag aagaccatct ccaaggcaaa gggacagcca agggagccac aggtgtacac     1140

actgcctcca agccgcgacg agctgaccaa gaaccaggtg tccctgacat gtctggtgaa     1200

gggcttctat ccatccgata tcgccgtgga gtgggagtct aatggccagc ccgagaacaa     1260

ttacaagacc acaccccctg tgctggacag cgatggctcc ttctttctgt attccaagct     1320

gaccgtggac aagtctcggt ggcagcaggg caacgtgttt tcctgctctg tgatgcacga     1380

ggccctgcac aatcactaca cccagaagag cctgtccctg tctcctggca agaggggaag     1440

gaagcggaga agcggctccg gagccacaaa cttcagcctg ctgaagcagg ccggcgatgt     1500

ggaggagaat cctggcccaa tggtgctgca gacccaggtg tttatctctc tgctgctgtg     1560

gatcagcgga gcatacggcg gctccgagct gacacaggac ccagccgtga gcgtggccct     1620

gggacagacc gtgaggatca catgtcaggg cgatagcctg cgcaactact atgcctcctg     1680

gtaccagcag aagcctcggc aggccccagt gctggtgttc tatggcaaga acaataggcc     1740

ctctggcatc cctgaccgct ttagcggcag ctcctctggc aataccgcaa gcctgacaat     1800

ctccggagca caggcagagg acgaggcaga ttactattgc aacagcagag atagctcctc     1860

taatcacctg gtgttcggcg gcggaaccaa gctgacagtg ctgtctaccg tggccgcccc     1920

aagcgtgttc atctttccac cctccgacga gcagctgaag tctggcacag ccagcgtggt     1980

gtgcctgctg aacaacttct acccccggga ggccaaggtg cagtggaagg tggataacgc     2040

cctgcagtct ggcaatagcc aggagtccgt gaccgagcag gactctaagg atagcacata     2100

ttctctgagc aacaccctga cactgagcaa ggccgactac gagaagcaca aggtgtatgc     2160

atgcgaggtg acccaccagg gactgagctc cccagtgaca aagtccttca atagaggcga     2220

gtgttgataa ct                                                         2232


<210>  147
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DMAb13

<400>  147

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Val Ser Gly Leu Thr Phe 
        35                  40                  45              


Ser Asn Phe Gly Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Phe Ile Arg Phe Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Gly Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Phe Cys Gly Arg Val Leu Tyr Gly Ala Ala Ala Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
465                 470                 475                 480 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
            500                 505                 510         


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
        515                 520                 525             


Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Thr Ser Ser His Ser 
    530                 535                 540                 


Leu Leu Tyr Ser Ser Asp Asn Lys Asn Tyr Leu Thr Trp Tyr Gln Gln 
545                 550                 555                 560 


Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
                565                 570                 575     


Gln Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
            580                 585                 590         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr 
        595                 600                 605             


Tyr Cys Gln Gln Tyr Tyr Thr Lys Ser Phe Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Val Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
625                 630                 635                 640 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                645                 650                 655     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            660                 665                 670         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        675                 680                 685             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys 
    690                 695                 700                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
705                 710                 715                 720 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735 


<210>  148
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX9261, DMAb13

<400>  148
catggactgg acctggagaa tcctgttcct ggtggcagca gcaaccggaa cacacgcaca       60

ggtgcagctg gtggagagcg gcggcggcgt ggtgcagcct ggcggctctc tgagactgag      120

ctgcgaggtg tccggcctga ccttcagcaa ctttggaatg cagtgggtga ggcaggcacc      180

aggcaaggga ctggagtggg tggccttcat ccgctttgac ggctctaata agtactatgc      240

cgatagcgtg aagggccggt tcaccatctc tagagacaac agcaagaata cagtgtacct      300

gcagatgggc agcctgaggg cagaggacac cgccgtgtac ttctgcggac gcgtgctgta      360

tggagcagca gcagattttt ggggacaggg caccctggtg acagtgagct ccgcctctac      420

aaagggacca agcgtgtttc cactggcacc ctctagcaag tccacctctg gcggcacagc      480

cgccctgggc tgtctggtga aggattactt ccccgagcct gtgaccgtga gctggaactc      540

cggcgccctg acctccggag tgcacacatt tccagccgtg ctgcagtcct ctggcctgta      600

cagcctgagc tccgtggtga ccgtgccctc tagctccctg ggcacccaga catatatctg      660

caacgtgaat cacaagccaa gcaatacaaa ggtggacaag aaggtggagc ccaagtcctg      720

tgataagacc cacacatgcc ctccctgtcc agcaccagag ctgctgggcg gcccaagcgt      780

gttcctgttt ccacccaagc ctaaggacac cctgatgatc tctagaaccc ccgaggtgac      840

atgcgtggtg gtggacgtga gccacgagga ccccgaggtg aagttcaact ggtacgtgga      900

tggcgtggag gtgcacaatg ccaagacaaa gcctcgggag gagcagtaca actccaccta      960

tagagtggtg tctgtgctga cagtgctgca ccaggactgg ctgaacggca aggagtataa     1020

gtgcaaggtg tccaataagg ccctgcctgc cccaatcgag aagaccatct ctaaggcaaa     1080

gggacagcct cgggagccac aggtgtacac actgcctcca tccagagacg agctgaccaa     1140

gaaccaggtg tctctgacat gtctggtgaa gggcttctat ccttctgata tcgccgtgga     1200

gtgggagagc aatggccagc cagagaacaa ttacaagacc acaccccctg tgctggactc     1260

tgatggcagc ttctttctgt attccaagct gaccgtggac aagtctcggt ggcagcaggg     1320

caacgtgttt agctgctccg tgatgcacga ggccctgcac aatcactaca cccagaagtc     1380

tctgagcctg tccccaggca agaggggaag gaagcggaga tctggcagcg gagccacaaa     1440

cttctccctg ctgaagcagg caggcgatgt ggaggagaat ccaggaccta tggtgctgca     1500

gacccaggtg tttatcagcc tgctgctgtg gatctccggc gcctatggcg acatcgtgat     1560

gacacagtcc ccagattctc tggccgtgtc cctgggagag agggcaacca tcaactgtac     1620

atctagccac agcctgctgt actcctctga caacaagaat tacctgacct ggtatcagca     1680

gaaggccggc cagccaccca agctgctgat ctattgggca tccaccaggc agtctggagt     1740

gccagaccgc ttctccggct ctggcagcgg cacagagttt accctgacaa tcagctccct     1800

gcaggccgag gatgtggccg tgtactattg ccagcagtac tataccaaga gcttcacatt     1860

tggccagggc accaaggtgg agatcaagac agtggccgcc cccagcgtgt tcatctttcc     1920

tccatccgac gagcagctga agagcggaac cgcatccgtg gtgtgcctgc tgaacaattt     1980

ctaccctagg gaggccaagg tgcagtggaa ggtggataac gccctgcaga gcggcaattc     2040

ccaggagtct gtgaccgagc aggacagcaa ggattccaca tattccctgt ctaacaccct     2100

gacactgtcc aaggccgatt acgagaagca caaggtgtat gcctgcgagg tgacccacca     2160

gggcctgtct agccctgtga caaagagctt taatcgcggc gagtgttgat aact           2214


<210>  149
<211>  2067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Marburg GP1 Consensus

<400>  149
ggatccgcca ccatgaagac cacatgcctg ttcatcagcc tgatcctgat ccagggcgtg       60

aagaccctgc caatcctgga gatcgcctcc aacaatcagc cccagaacgt ggacagcgtg      120

tgctctggca ccctgcagaa gacagaggat gtgcacctga tgggcttcac actgagcgga      180

cagaaggtgg cagactcccc actggaggcc tctaagaggt gggcctttag aaccggcgtg      240

ccccctaaga acgtggagta caccgagggc gaggaggcca agacatgcta taatatctcc      300

gtgaccgatc ccagcggcaa gtccctgctg ctggacccac ccacaaacat cagggattac      360

cctaagtgta agaccatcca ccacatccag ggccagaatc cacacgcaca gggaatcgcc      420

ctgcacctgt ggggcgcctt ctttctgtac gacaggatcg ccagcaccac aatgtataga      480

ggcaaggtgt tcacagaggg caacatcgcc gccatgatcg tgaataagac cgtgcacaag      540

atgatctttt ctaggcaggg ccagggctac agacacatga acctgacaag caccaataag      600

tattggacaa gctccaacgg cacacagacc aatgacaccg gatgcttcgg cgccctgcag      660

gagtacaact ccaccaagaa tcagacatgt gccccatcta agatccctct gccactgcca      720

acagcaaggc cagaggtgaa gctgacatct accagcacag acgccaccaa gctgaacacc      780

acagacccca attccgacga tgaggatctg accacatccg gctctggcag cggagagcag      840

gagccttata ccacatctga tgccgccacc aagcagggcc tgtctagcac catgcctcca      900

acacctagcc cacagccctc cacacctcag caggagggca acaataccaa ccactctcag      960

ggagcagtga ccgagcctgg caagacaaac accacagccc agccaagcat gccccctcac     1020

aataccacag ccatcagcac caacaataca tccaagcaca acttttctac ccctagcgtg     1080

ccactgcaga atgccaccaa ctacaataca cagtccaccg ccacagagaa cgagcagaca     1140

tccgccccct ctaagaccac actgccaccc accgagaacc ctaccacagc caagagcacc     1200

aattccacaa agtctccaac cacaaccgtg cccaacacaa ccaataagca ctccacctct     1260

cctagcccaa cccccaaccc tacagcccag cacctggtgt atttcaggag aaagcggaat     1320

atcctgtggc gcgagggcga catgttcccc tttctggatg gcctgatcaa cgcccctatc     1380

gacttcgatc cagtgcccaa taccaagaca atctttgacg agtcctctag ctccggagca     1440

agcgccgagg aggatcagca cgcctctcct aacatcagcc tgacactgtc ctactttcca     1500

aagatcaacg agaataccgc ctattccggc gagaacgaga atgactgcga tgccgagctg     1560

aggatctgga gcgtgcagga ggacgatctg gcagcaggac tgtcctggat tcccttcttc     1620

ggacctggaa tcgagggact gtacaccgca ggactgatca agaaccagaa caacctggtg     1680

tgcagactgc ggcgcctggc caatcagaca gccaagtccc tggagctgct gctgcgggtg     1740

acaaccgagg agcgcacctt ctctctgatc aaccggcacg ccatcgactt tctgctggca     1800

agatggggcg gcacctgcaa ggtgctggga ccagactgct gtatcggcat cgaggatctg     1860

tctcggaata tcagcgagca gatcgaccag atcaagaagg atgagcagaa ggagggaacc     1920

ggatggggac tgggcggcaa gtggtggaca agcgattggg gcgtgctgac caacctgggc     1980

atcctgctgc tgctgtctat cgccgtgctg atcgccctga gctgcatctg tcgcatcttc     2040

accaagtata tcggctgata actcgag                                         2067


<210>  150
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Marburg GP1 Consensus

<400>  150

Met Lys Thr Thr Cys Leu Phe Ile Ser Leu Ile Leu Ile Gln Gly Val 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Asn Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ala Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Ile Pro Leu Pro Leu Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Val Lys Leu Thr Ser Thr Ser Thr Asp Ala Thr Lys Leu Asn Thr 
                245                 250                 255     


Thr Asp Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Ala Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Ser Thr 
    290                 295                 300                 


Pro Gln Gln Glu Gly Asn Asn Thr Asn His Ser Gln Gly Ala Val Thr 
305                 310                 315                 320 


Glu Pro Gly Lys Thr Asn Thr Thr Ala Gln Pro Ser Met Pro Pro His 
                325                 330                 335     


Asn Thr Thr Ala Ile Ser Thr Asn Asn Thr Ser Lys His Asn Phe Ser 
            340                 345                 350         


Thr Pro Ser Val Pro Leu Gln Asn Ala Thr Asn Tyr Asn Thr Gln Ser 
        355                 360                 365             


Thr Ala Thr Glu Asn Glu Gln Thr Ser Ala Pro Ser Lys Thr Thr Leu 
    370                 375                 380                 


Pro Pro Thr Glu Asn Pro Thr Thr Ala Lys Ser Thr Asn Ser Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Thr Val Pro Asn Thr Thr Asn Lys His Ser Thr Ser 
                405                 410                 415     


Pro Ser Pro Thr Pro Asn Pro Thr Ala Gln His Leu Val Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Asn Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Pro Asn Ile Ser Leu Thr Leu Ser Tyr Phe Pro 
                485                 490                 495     


Lys Ile Asn Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Ala Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  151
<211>  2067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Marburg GP2 Consensus

<400>  151
ggatccgcca ccatgcggac cacatgcttc tttatcagcc tgatcctgat ccagggcatc       60

aagaccctgc caatcctgga gatcgcctcc aacgaccagc cccagaatgt ggatagcgtg      120

tgctccggca ccctgcagaa gacagaggac gtgcacctga tgggcttcac actgtctggc      180

cagaaggtgg ccgatagccc cctggaggcc tctaagaggt gggcctttag aaccggcgtg      240

ccccctaaga acgtggagta caccgagggc gaggaggcca agacatgcta taatatcagc      300

gtgaccgacc cttctggcaa gagcctgctg ctggacccac ccacaaacgt gcgcgattac      360

cctaagtgta agaccatcca ccacatccag ggccagaatc cacacgcaca gggaatcgcc      420

ctgcacctgt ggggcgcctt ctttctgtac gataggatcg cctccaccac aatgtataga      480

ggcaaggtgt tcacagaggg caacatcgcc gccatgatcg tgaataagac cgtgcacaag      540

atgatctttt ccaggcaggg ccagggctac agacacatga acctgacatc taccaataag      600

tattggacca gctccaacgg cacacagacc aatgacaccg gctgcttcgg cacactgcag      660

gagtacaact ccaccaagaa tcagacatgt gccccttcta agacccctcc accccctcca      720

acagcaaggc cagagatcaa gcctacaagc accccaacag acgccaccag actgaacacc      780

acaaacccca attccgacga tgaggatctg accacaagcg gctccggctc tggagagcag      840

gagccttata ccacatccga cgccgtgacc aagcagggcc tgtctagcac catgccccct      900

acaccttccc cacagccagg aacacctcag cagggcggca acaataccaa ccactctcag      960

gacgccacca cagagctgga taacacaaat accacagccc agccacccat gccaagccac     1020

aataccacaa ccatcagcac caacaataca tccaagcaca acctgtccac cctgtctgag     1080

cctccacaga atacaaccaa cccaaatacc cagagcatgg tgacagagaa cgagaagacc     1140

agcgcccctc ccaaggccac cctgccaccc acagagaatc ccacaaccga gaagtctacc     1200

aacaatacaa agagccctac aaccctggag ccaaacaaga caaatggcca cttcaccagc     1260

ccctcctcta cacctaactc cacaacccag cacctgatct actttaggag aaagcggtcc     1320

atcctgtggc gcgagggcga catgttcccc tttctggatg gcctgatcaa cgcccctatc     1380

gacttcgatc ctgtgccaaa taccaagaca atctttgacg agagctcctc tagcggagca     1440

agcgccgagg aggatcagca cgcctcctct aacatcagcc tgaccctgtc ctacctgcca     1500

cacacctccg agaatacagc ctattctggc gagaacgaga atgactgcga tgccgagctg     1560

cggatctggt ctgtgcagga ggacgatctg gcagcaggac tgagctggat tcccctgttc     1620

ggaccaggaa tcgagggact gtataccgcc ggcctgatca agaaccagaa caacctggtg     1680

tgcaggctgc ggcgcctggc aaatcagaca gccaagtctc tggagctgct gctgcgggtg     1740

acaaccgagg agcgcacctt cagcctgatc aaccggcacg ccatcgactt tctgctgacc     1800

cgctggggcg gcacatgcaa ggtgctggga ccagactgct gtatcggcat cgaggatctg     1860

tctaggaaca tcagcgagca gatcgaccag atcaagaagg atgagcagaa ggagggaacc     1920

ggatggggac tgggcggcaa gtggtggaca agcgattggg gcgtgctgac caacctgggc     1980

atcctgctgc tgctgtctat cgccgtgctg atcgccctga gctgcatctg tagaatcttt     2040

accaagtata tcggctgata actcgag                                         2067


<210>  152
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Marburg GP2 Consensus

<400>  152

Met Arg Thr Thr Cys Phe Phe Ile Ser Leu Ile Leu Ile Gln Gly Ile 
1               5                   10                  15      


Lys Thr Leu Pro Ile Leu Glu Ile Ala Ser Asn Asp Gln Pro Gln Asn 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Thr Asn 
            100                 105                 110         


Val Arg Asp Tyr Pro Lys Cys Lys Thr Ile His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Ile Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Lys 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Gly Thr Gln Thr Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Thr Leu Gln Glu Tyr Asn Ser Thr Lys Asn Gln 
    210                 215                 220                 


Thr Cys Ala Pro Ser Lys Thr Pro Pro Pro Pro Pro Thr Ala Arg Pro 
225                 230                 235                 240 


Glu Ile Lys Pro Thr Ser Thr Pro Thr Asp Ala Thr Arg Leu Asn Thr 
                245                 250                 255     


Thr Asn Pro Asn Ser Asp Asp Glu Asp Leu Thr Thr Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Glu Pro Tyr Thr Thr Ser Asp Ala Val Thr Lys Gln 
        275                 280                 285             


Gly Leu Ser Ser Thr Met Pro Pro Thr Pro Ser Pro Gln Pro Gly Thr 
    290                 295                 300                 


Pro Gln Gln Gly Gly Asn Asn Thr Asn His Ser Gln Asp Ala Thr Thr 
305                 310                 315                 320 


Glu Leu Asp Asn Thr Asn Thr Thr Ala Gln Pro Pro Met Pro Ser His 
                325                 330                 335     


Asn Thr Thr Thr Ile Ser Thr Asn Asn Thr Ser Lys His Asn Leu Ser 
            340                 345                 350         


Thr Leu Ser Glu Pro Pro Gln Asn Thr Thr Asn Pro Asn Thr Gln Ser 
        355                 360                 365             


Met Val Thr Glu Asn Glu Lys Thr Ser Ala Pro Pro Lys Ala Thr Leu 
    370                 375                 380                 


Pro Pro Thr Glu Asn Pro Thr Thr Glu Lys Ser Thr Asn Asn Thr Lys 
385                 390                 395                 400 


Ser Pro Thr Thr Leu Glu Pro Asn Lys Thr Asn Gly His Phe Thr Ser 
                405                 410                 415     


Pro Ser Ser Thr Pro Asn Ser Thr Thr Gln His Leu Ile Tyr Phe Arg 
            420                 425                 430         


Arg Lys Arg Ser Ile Leu Trp Arg Glu Gly Asp Met Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Asn Ala Pro Ile Asp Phe Asp Pro Val Pro Asn Thr 
    450                 455                 460                 


Lys Thr Ile Phe Asp Glu Ser Ser Ser Ser Gly Ala Ser Ala Glu Glu 
465                 470                 475                 480 


Asp Gln His Ala Ser Ser Asn Ile Ser Leu Thr Leu Ser Tyr Leu Pro 
                485                 490                 495     


His Thr Ser Glu Asn Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Leu Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Arg Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Gln Ile Lys Lys Asp Glu Gln Lys Glu Gly Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  153
<211>  2067
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Marburg GP3 Consensus

<400>  153
ggatccgcca ccatgaagac aatctacttc ctgatctctc tgatcctgat ccagagcatc       60

aagaccctgc cagtgctgga gatcgcctcc aactctcagc cccaggacgt ggatagcgtg      120

tgctctggca ccctgcagaa gacagaggac gtgcacctga tgggcttcac actgtccggc      180

cagaaggtgg ccgattcccc tctggaggcc tctaagaggt gggcctttag aaccggcgtg      240

ccccctaaga acgtggagta caccgagggc gaggaggcca agacatgcta taatatctcc      300

gtgaccgacc caagcggcaa gtccctgctg ctggacccac cctctaacat cagggattac      360

cccaagtgta agaccgtgca ccacatccag ggccagaatc ctcacgcaca gggaatcgcc      420

ctgcacctgt ggggcgcctt ctttctgtac gatcgggtgg ccagcaccac aatgtatcgc      480

ggcaaggtgt tcacagaggg caacatcgcc gccatgatcg tgaataagac cgtgcaccgg      540

atgatctttt ctcgccaggg ccagggctac aggcacatga acctgaccag cacaaataag      600

tattggacaa gctccaacga gacccagaga aatgacacag gctgctttgg catcctgcag      660

gagtataact ccaccaacaa tcagacatgt cctccaagcc tgaagccccc ttccctgcct      720

accgtgacac catctatcca cagcaccaac acacagatca ataccgccaa gagcggcaca      780

atgaaccctt ctagcgacga tgaggacctg atgatcagcg gctccggctc tggagagcag      840

ggaccacaca ccacactgaa tgtggtgacc gagcagaagc agtcctctac catcctgtcc      900

acaccatctc tgcacctgag cacatcccag cacgagcaga actctaccaa tcccagccgg      960

cacgcagtga ccgagcacaa cggcacagac cccaccacac agcctgccac cctgctgaac     1020

aatacaaata ccacacctac ctacaacaca ctgaagtata atctgagcac accatcccca     1080

cccaccagga acatcacaaa caatgatacc cagagagagc tggccgagtc cgagcagacc     1140

aacgcccagc tgaataccac actggaccca acagagaacc ccaccacagg ccaggatacc     1200

aactctacca caaatatcat catgaccaca tccgacatca cctctaagca cccaacaaat     1260

agctcccctg attctagccc aaccacacgc cctccaatct acttcaggaa gaagaggagc     1320

atcttttgga aggagggcga catcttcccc tttctggatg gcctgatcag caccgagatc     1380

gacttcgatc caatccccaa caccgagaca atcttcgacg agtctcccag ctttaacacc     1440

tccacaaatg aggagcagca cacaccccct aacatcagcc tgaccttctc ctactttcct     1500

gacaagaatg gcgataccgc ctatagcggc gagaacgaga atgactgcga tgccgagctg     1560

cggatctgga gcgtgcagga ggacgatctg gcagcaggac tgtcctggat tcccttcttc     1620

ggccctggca tcgagggcct gtataccgcc ggcctgatca agaaccagaa caacctggtg     1680

tgccgcctga ggagactggc caatcagaca gccaagagcc tggagctgct gctgagggtg     1740

accacagagg agagaacctt ctccctgatc aaccggcacg ccatcgactt tctgctgacc     1800

cgctggggcg gcacatgcaa ggtgctggga ccagactgct gtatcggcat cgaggatctg     1860

tctaagaata tcagcgagca gatcgacaag atcaggaagg atgagcagaa ggaggagacc     1920

ggatggggac tgggcggcaa gtggtggaca agcgattggg gcgtgctgac caacctgggc     1980

atcctgctgc tgctgtccat cgccgtgctg atcgccctgt cttgcatctg tagaatcttc     2040

accaagtaca tcggctgata actcgag                                         2067


<210>  154
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Marburg GP3 Consensus

<400>  154

Met Lys Thr Ile Tyr Phe Leu Ile Ser Leu Ile Leu Ile Gln Ser Ile 
1               5                   10                  15      


Lys Thr Leu Pro Val Leu Glu Ile Ala Ser Asn Ser Gln Pro Gln Asp 
            20                  25                  30          


Val Asp Ser Val Cys Ser Gly Thr Leu Gln Lys Thr Glu Asp Val His 
        35                  40                  45              


Leu Met Gly Phe Thr Leu Ser Gly Gln Lys Val Ala Asp Ser Pro Leu 
    50                  55                  60                  


Glu Ala Ser Lys Arg Trp Ala Phe Arg Thr Gly Val Pro Pro Lys Asn 
65                  70                  75                  80  


Val Glu Tyr Thr Glu Gly Glu Glu Ala Lys Thr Cys Tyr Asn Ile Ser 
                85                  90                  95      


Val Thr Asp Pro Ser Gly Lys Ser Leu Leu Leu Asp Pro Pro Ser Asn 
            100                 105                 110         


Ile Arg Asp Tyr Pro Lys Cys Lys Thr Val His His Ile Gln Gly Gln 
        115                 120                 125             


Asn Pro His Ala Gln Gly Ile Ala Leu His Leu Trp Gly Ala Phe Phe 
    130                 135                 140                 


Leu Tyr Asp Arg Val Ala Ser Thr Thr Met Tyr Arg Gly Lys Val Phe 
145                 150                 155                 160 


Thr Glu Gly Asn Ile Ala Ala Met Ile Val Asn Lys Thr Val His Arg 
                165                 170                 175     


Met Ile Phe Ser Arg Gln Gly Gln Gly Tyr Arg His Met Asn Leu Thr 
            180                 185                 190         


Ser Thr Asn Lys Tyr Trp Thr Ser Ser Asn Glu Thr Gln Arg Asn Asp 
        195                 200                 205             


Thr Gly Cys Phe Gly Ile Leu Gln Glu Tyr Asn Ser Thr Asn Asn Gln 
    210                 215                 220                 


Thr Cys Pro Pro Ser Leu Lys Pro Pro Ser Leu Pro Thr Val Thr Pro 
225                 230                 235                 240 


Ser Ile His Ser Thr Asn Thr Gln Ile Asn Thr Ala Lys Ser Gly Thr 
                245                 250                 255     


Met Asn Pro Ser Ser Asp Asp Glu Asp Leu Met Ile Ser Gly Ser Gly 
            260                 265                 270         


Ser Gly Glu Gln Gly Pro His Thr Thr Leu Asn Val Val Thr Glu Gln 
        275                 280                 285             


Lys Gln Ser Ser Thr Ile Leu Ser Thr Pro Ser Leu His Leu Ser Thr 
    290                 295                 300                 


Ser Gln His Glu Gln Asn Ser Thr Asn Pro Ser Arg His Ala Val Thr 
305                 310                 315                 320 


Glu His Asn Gly Thr Asp Pro Thr Thr Gln Pro Ala Thr Leu Leu Asn 
                325                 330                 335     


Asn Thr Asn Thr Thr Pro Thr Tyr Asn Thr Leu Lys Tyr Asn Leu Ser 
            340                 345                 350         


Thr Pro Ser Pro Pro Thr Arg Asn Ile Thr Asn Asn Asp Thr Gln Arg 
        355                 360                 365             


Glu Leu Ala Glu Ser Glu Gln Thr Asn Ala Gln Leu Asn Thr Thr Leu 
    370                 375                 380                 


Asp Pro Thr Glu Asn Pro Thr Thr Gly Gln Asp Thr Asn Ser Thr Thr 
385                 390                 395                 400 


Asn Ile Ile Met Thr Thr Ser Asp Ile Thr Ser Lys His Pro Thr Asn 
                405                 410                 415     


Ser Ser Pro Asp Ser Ser Pro Thr Thr Arg Pro Pro Ile Tyr Phe Arg 
            420                 425                 430         


Lys Lys Arg Ser Ile Phe Trp Lys Glu Gly Asp Ile Phe Pro Phe Leu 
        435                 440                 445             


Asp Gly Leu Ile Ser Thr Glu Ile Asp Phe Asp Pro Ile Pro Asn Thr 
    450                 455                 460                 


Glu Thr Ile Phe Asp Glu Ser Pro Ser Phe Asn Thr Ser Thr Asn Glu 
465                 470                 475                 480 


Glu Gln His Thr Pro Pro Asn Ile Ser Leu Thr Phe Ser Tyr Phe Pro 
                485                 490                 495     


Asp Lys Asn Gly Asp Thr Ala Tyr Ser Gly Glu Asn Glu Asn Asp Cys 
            500                 505                 510         


Asp Ala Glu Leu Arg Ile Trp Ser Val Gln Glu Asp Asp Leu Ala Ala 
        515                 520                 525             


Gly Leu Ser Trp Ile Pro Phe Phe Gly Pro Gly Ile Glu Gly Leu Tyr 
    530                 535                 540                 


Thr Ala Gly Leu Ile Lys Asn Gln Asn Asn Leu Val Cys Arg Leu Arg 
545                 550                 555                 560 


Arg Leu Ala Asn Gln Thr Ala Lys Ser Leu Glu Leu Leu Leu Arg Val 
                565                 570                 575     


Thr Thr Glu Glu Arg Thr Phe Ser Leu Ile Asn Arg His Ala Ile Asp 
            580                 585                 590         


Phe Leu Leu Thr Arg Trp Gly Gly Thr Cys Lys Val Leu Gly Pro Asp 
        595                 600                 605             


Cys Cys Ile Gly Ile Glu Asp Leu Ser Lys Asn Ile Ser Glu Gln Ile 
    610                 615                 620                 


Asp Lys Ile Arg Lys Asp Glu Gln Lys Glu Glu Thr Gly Trp Gly Leu 
625                 630                 635                 640 


Gly Gly Lys Trp Trp Thr Ser Asp Trp Gly Val Leu Thr Asn Leu Gly 
                645                 650                 655     


Ile Leu Leu Leu Leu Ser Ile Ala Val Leu Ile Ala Leu Ser Cys Ile 
            660                 665                 670         


Cys Arg Ile Phe Thr Lys Tyr Ile Gly 
        675                 680     


<210>  155
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  155

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        35                  40                  45              


Ser Ser Asn Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
65                  70                  75                  80  


Asp Tyr Ala Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val Phe Gly 
        115                 120                 125             


Val Asn Val Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg 
465                 470                 475                 480 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
                485                 490                 495     


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
            500                 505                 510         


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Ile 
        515                 520                 525             


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
    530                 535                 540                 


Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr Leu His 
545                 550                 555                 560 


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
                565                 570                 575     


Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
            580                 585                 590         


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
        595                 600                 605             


Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Val Glu Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
625                 630                 635                 640 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                645                 650                 655     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            660                 665                 670         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        675                 680                 685             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys 
    690                 695                 700                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
705                 710                 715                 720 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735 


<210>  156
<211>  745
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza B DMAb

<400>  156

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe 
        35                  40                  45              


Leu Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Arg Ile Lys Ser Asn Thr Asp Gly Gly Thr Thr Asp 
65                  70                  75                  80  


Tyr Ala Ala Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Thr Thr Asp Gly Pro Tyr Ser Asp Asp Phe Arg 
        115                 120                 125             


Ser Gly Tyr Ala Ala Arg Tyr Arg Tyr Phe Gly Met Asp Val Trp Gly 
    130                 135                 140                 


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
145                 150                 155                 160 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
                165                 170                 175     


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
            180                 185                 190         


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
        195                 200                 205             


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
    210                 215                 220                 


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
225                 230                 235                 240 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
                485                 490                 495     


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            500                 505                 510         


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
        515                 520                 525             


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser 
    530                 535                 540                 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
545                 550                 555                 560 


Ile Ser Thr Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
                565                 570                 575     


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
            580                 585                 590         


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        595                 600                 605             


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn 
    610                 615                 620                 


Ser Phe Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Thr 
625                 630                 635                 640 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
                645                 650                 655     


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
            660                 665                 670         


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
        675                 680                 685             


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
    690                 695                 700                 


Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
705                 710                 715                 720 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
                725                 730                 735     


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            740                 745 


<210>  157
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  157

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Asp Ile Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Ser Ser Asn Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Lys 
65                  70                  75                  80  


Pro Ser Leu Glu Ser Arg Leu Gly Ile Ser Val Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Lys Leu Ser Phe Val Ser Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Val Arg Ser Gly Tyr Pro Asp Thr Ala Tyr 
        115                 120                 125             


Tyr Phe Asp Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Ser Tyr Val Leu Thr Gln 
        515                 520                 525             


Pro Pro Ser Val Ser Val Ala Pro Gly Glu Thr Ala Arg Ile Ser Cys 
    530                 535                 540                 


Gly Gly Asn Asn Ile Gly Thr Lys Val Leu His Trp Tyr Gln Gln Thr 
545                 550                 555                 560 


Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro 
                565                 570                 575     


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
            580                 585                 590         


Thr Leu Thr Ile Ser Arg Val Glu Val Gly Asp Glu Ala Asp Tyr Tyr 
        595                 600                 605             


Cys Gln Val Trp Asp Ile Ser Thr Asp Gln Ala Val Phe Gly Gly Gly 
    610                 615                 620                 


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
625                 630                 635                 640 


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
                645                 650                 655     


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
            660                 665                 670         


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
        675                 680                 685             


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
    690                 695                 700                 


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
705                 710                 715                 720 


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                725                 730                 735     


<210>  158
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  158

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Ala Asn Tyr Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu 
        115                 120                 125             


Trp Leu Ser Gln Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
    130                 135                 140                 


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
145                 150                 155                 160 


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
                165                 170                 175     


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
            180                 185                 190         


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
        195                 200                 205             


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
    210                 215                 220                 


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
225                 230                 235                 240 


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly 
465                 470                 475                 480 


Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                485                 490                 495     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr 
            500                 505                 510         


Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp 
        515                 520                 525             


Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
    530                 535                 540                 


Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Thr Phe Asn Tyr 
545                 550                 555                 560 


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
                565                 570                 575     


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
            580                 585                 590         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        595                 600                 605             


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Tyr Arg 
    610                 615                 620                 


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val 
625                 630                 635                 640 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
                645                 650                 655     


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
            660                 665                 670         


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
        675                 680                 685             


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
    690                 695                 700                 


Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
705                 710                 715                 720 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
                725                 730                 735     


Lys Ser Phe Asn Arg Gly Glu Cys 
            740                 


<210>  159
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  159

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        35                  40                  45              


Ser Ser Asn Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
65                  70                  75                  80  


Asp Tyr Ala Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val Phe Gly 
        115                 120                 125             


Val Asn Val Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  160
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  160

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser 
        35                  40                  45              


Leu Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
            100                 105                 110         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys 
225                 


<210>  161
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  161

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val 
        35                  40                  45              


Ser Ser Asn Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg 
    50                  55                  60                  


Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn 
65                  70                  75                  80  


Asp Tyr Ala Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr 
                85                  90                  95      


Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val Phe Gly 
        115                 120                 125             


Val Asn Val Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Thr Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  162
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  162

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser 
        35                  40                  45              


Leu Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg 
            100                 105                 110         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Val Ala Ala Pro 
        115                 120                 125             


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
    130                 135                 140                 


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
145                 150                 155                 160 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
                165                 170                 175     


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn 
            180                 185                 190         


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
        195                 200                 205             


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
    210                 215                 220                 


Asn Arg Gly Glu Cys 
225                 


<210>  163
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  163
atggattgga cttggaggat tctgtttctg gtcgccgccg ctactggaac tcacgctcag       60

gtgcagctgc agcagtctgg acccggactg gtgaagcctt cacagactct gagcctgacc      120

tgcgccatct ccggcgactc tgtgagctcc aacaatgctg tctggaactg gattagacag      180

tccccatctc gggggctgga atggctggga cgaacatact ataggagcaa atggtacaat      240

gactatgctg agagtgtgaa gtcacgaatc acaattaacc cagatactag caagaatcag      300

ttctccctgc agctgaactc tgtgacaccc gaggatactg cagtctacta ttgcgcacgc      360

tccggacaca tcaccgtgtt cggagtcaat gtggacgcct ttgatatgtg gggacagggg      420

accacagtca cagtgtctag tgcaagtact aaaggcccat cagtgtttcc cctggcccct      480

tcaagcaaga gtacctcagg cggaacagcc gctctgggat gtctggtgaa ggactacttc      540

cctgagccag tcaccgtgag ctggaactcc ggagctctga ccagcggggt gcatacattt      600

cctgcagtcc tgcagtcctc tggcctgtac agcctgagtt cagtggtcac cgtgccaagc      660

tcctctctgg gaacacagac ttatatctgc aacgtgaatc acaaaccatc caatacaaag      720

gtcgacaaga aagtggaacc caaatcttgt gataagaccc atacatgccc tccctgtcca      780

gcacctgagc tgctgggcgg cccatccgtg ttcctgtttc cacccaagcc taaagacaca      840

ctgatgatta gccggactcc cgaagtgacc tgcgtggtcg tggacgtgag ccacgaggac      900

cccgaagtga agttcaactg gtacgtggat ggcgtcgagg tgcataatgc caagaccaaa      960

cctagggagg aacagtacaa cagcacttat agagtcgtgt ccgtcctgac cgtgctgcac     1020

caggattggc tgaacgggaa ggagtataag tgcaaagtgt ccaacaaggc cctgccagct     1080

cccatcgaga agaccatttc taaggccaaa ggccagccac gggaacccca ggtgtacaca     1140

ctgcctccaa gccgcgacga gctgaccaaa aaccaggtga gcctgacatg tctggtcaag     1200

ggattctatc ctagtgatat cgctgtggag tgggaatcta atgggcagcc agaaaacaat     1260

tacaagacta cccctcccgt gctggactct gatggaagtt tctttctgta ttcaaaactg     1320

accgtggaca agagccgctg gcagcagggg aacgtcttta gctgctccgt gatgcacgag     1380

gccctgcaca atcattacac tcagaaatct ctgagtctgt cacccggaaa acgaggacga     1440

aagaggagaa gcggctccgg agctaccaac ttctccctgc tgaagcaggc aggggatgtg     1500

gaggaaaatc ctggcccaat ggtcctgcag acacaggtgt ttatctctct gctgctgtgg     1560

attagtggcg cttacggaga catccagatg actcagtctc ctagttcact gtctgcaagt     1620

gtcggcgatc gcgtgactat tacctgtcga acctcacaga gcctgagctc ctacctgcat     1680

tggtatcagc agaagcctgg gaaagcacca aagctgctga tctatgcagc ctctagtctg     1740

cagtccggcg tgccctctag gttctccggg tctggcagtg gaactgactt tacactgact     1800

atttcaagcc tgcagcctga ggatttcgct acctactatt gccagcagag cagaactttt     1860

gggcagggca ccaaagtcga aatcaagaca gtggctgcac catccgtctt catttttcca     1920

ccctctgacg agcagctgaa gagtggaact gcctcagtgg tgtgcctgct gaacaatttc     1980

tacccccggg aagccaaagt ccagtggaag gtggataacg ctctgcagtc aggcaatagc     2040

caggagtccg tgacagaaca ggactctaaa gatagtactt attcactgag caacaccctg     2100

acactgagca aggcagacta cgagaagcac aaagtgtatg cctgcgaagt gacccaccag     2160

gggctgagca gtccagtgac caaatctttc aacaggggag aatgttgata a              2211


<210>  164
<211>  2241
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza B DMAb

<400>  164
atggactgga cttggaggat tctgtttctg gtggccgccg caactggcac tcatgccgag       60

gtgcagctgg tggaatcagg gggaggactg gtgaagcctg gcggatcact gcgactgagc      120

tgcgcagctt ccggactgac cttcctgaac gcttggatga gctgggtgcg acaggcacca      180

gggaaaggcc tggaatgggt cgggcgcatc aagagcaata cagacggcgg aaccacagat      240

tacgcagccc ccgtgaaagg caggttcacc atttctcggg acgatagtaa gaacacactg      300

tatctgcaga tgagctccct gaaaaccgag gacacagccg tgtactattg cactaccgat      360

ggcccctaca gcgacgattt ccgctccgga tatgctgcac ggtaccgcta ttttgggatg      420

gacgtgtggg gacaggggac aactgtcaca gtgtctagtg catctactaa gggacctagc      480

gtgttcccac tggccccctc aagcaaatca actagcggag ggaccgccgc tctgggatgt      540

ctggtgaagg attacttccc cgagcctgtc accgtgagct ggaactccgg ggccctgacc      600

tccggagtgc acacatttcc tgctgtcctg cagtcctctg ggctgtactc tctgagttca      660

gtggtcacag tgccaagctc ctctctgggc actcagacct atatctgcaa cgtgaatcac      720

aaacctagca atactaaggt cgacaagaaa gtggaaccaa aaagctgtga taagacacat      780

acttgccctc cctgtccagc tccagagctg ctgggcggac catccgtgtt cctgtttcca      840

cccaagccca aagacaccct gatgatttcc cggacaccag aagtgacttg cgtggtcgtg      900

gacgtgagcc acgaggaccc cgaagtgaag ttcaactggt acgtggatgg cgtcgaggtg      960

cataatgcca agacaaaacc cagggaggaa cagtacaact caacttatag agtcgtgagc     1020

gtcctgaccg tgctgcacca ggactggctg aacggcaagg agtataagtg caaagtgagc     1080

aacaaggccc tgcctgctcc aatcgagaag actattagca aggctaaagg acagcctcgg     1140

gaaccacagg tgtacaccct gcctccatcc cgcgacgagc tgaccaaaaa ccaggtgtct     1200

ctgacatgtc tggtcaaggg cttctatccc tctgatatcg ccgtggagtg ggaaagtaat     1260

ggacagcctg aaaacaatta caagaccaca ccccctgtgc tggactctga tggcagtttc     1320

tttctgtata gtaaactgac cgtggacaag tcaagatggc agcagggaaa cgtgttttcc     1380

tgctctgtca tgcatgaggc cctgcacaat cattacaccc agaagagtct gtcactgagc     1440

ccaggaaaac gagggaggaa gaggagatcc ggctctggag ccacaaactt ctccctgctg     1500

aagcaggctg gagacgtgga ggaaaatccc gggcctatgg tgctgcagac ccaggtcttt     1560

atctccctgc tgctgtggat ttctggcgct tacggagata tccagatgac acagtctccc     1620

agttcagtca gtgcatcagt gggcgaccgc gtcaccatca catgtcgagc atcacaggat     1680

attagcacct ggctggcctg gtaccagcag aagcccggaa aagctcctaa gctgctgatc     1740

tatgcagcca gctccctgca gtccggagtg ccctctaggt tcagcgggtc cggctctgga     1800

acagacttta ctctgaccat ttctagtctg cagcctgagg atttcgcaac ttactattgc     1860

cagcaggcca acagcttccc acccactttt gggcagggca ccaaactgga aatcaagact     1920

gtggctgcac ctagcgtctt catttttcct ccatccgacg agcagctgaa gagtggcacc     1980

gcctcagtgg tgtgcctgct gaacaacttc tacccaagag aagcaaaagt gcagtggaag     2040

gtcgataacg ccctgcagtc aggcaatagc caggagtccg tgacagaaca ggactctaag     2100

gatagtactt atagtctgtc aaatacactg actctgagca aagctgacta cgagaagcat     2160

aaagtgtatg catgcgaggt cactcaccag ggactgtctt cacccgtcac caaatctttc     2220

aatagaggag aatgctgata a                                               2241


<210>  165
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  165
atggactgga catggagaat cctgttcctg gtcgccgccg ctactgggac tcacgcagaa       60

gtgcagctgg tcgaatcagg gcctgggctg gtgaagccct cagacatcct gagcctgacc      120

tgcgccgtgt ctggctacag tatcagctcc aactactatt ggggatggat tcggcagccc      180

cctggcaagg gactggaatg gatcgggtcc atctaccact caggcagcac ctactataaa      240

ccttcactgg agagccgcct gggaatttcc gtggacacat ctaagaatca gttcagcctg      300

aaactgtcct ttgtctctgc cgctgatact gcagtgtact attgcgcccg acatgtcagg      360

tccggctacc cagacaccgc ttactatttt gataagtggg ggcagggcac cctggtcaca      420

gtgtctagtg ctagcaccaa gggcccctcc gtgttccctc tggcaccatc aagcaaatcc      480

acatctggcg gaactgcagc cctgggatgt ctggtgaagg attacttccc agagcccgtc      540

acagtgagtt ggaactcagg cgcactgact tctggagtcc acacctttcc cgccgtgctg      600

cagtcctctg gcctgtacag cctgagttca gtggtcacag tgcctagctc ctctctggga      660

actcagacct atatctgcaa cgtgaatcac aagccctcaa atactaaagt cgacaagaaa      720

gtggaaccta agtcttgtga taaaacacat acttgcccac catgtcctgc accagagctg      780

ctgggaggac caagcgtgtt cctgtttcct ccaaagccca aagacaccct gatgatctcc      840

agaacccctg aagtgacatg tgtggtcgtg gacgtctctc acgaggaccc cgaagtcaag      900

tttaactggt acgtggatgg cgtcgaggtg cataatgcta agacaaaacc ccgcgaggaa      960

cagtacaact caacctatcg agtcgtgagc gtcctgacag tgctgcacca ggactggctg     1020

aacggaaagg agtataagtg caaagtgagc aataaggcac tgcccgcccc tatcgagaaa     1080

actatttcca aggctaaagg gcagcccagg gaacctcagg tgtacaccct gcccccttct     1140

agagacgagc tgacaaagaa ccaggtcagt ctgacttgtc tggtgaaagg attttatcca     1200

agtgatatcg cagtggagtg ggaatcaaat gggcagcccg aaaacaatta caagaccaca     1260

ccacccgtgc tggacagcga tggcagcttc ttcctgtatt ccaagctgac cgtggacaaa     1320

tctcggtggc agcaggggaa cgtcttcagt tgctcagtga tgcacgaggc cctgcacaat     1380

cattacaccc agaagagcct gtccctgtct ccaggcaagc ggggacgcaa aaggagaagt     1440

ggatcagggg ccacaaactt ttccctgctg aaacaggctg gagatgtgga ggaaaatcca     1500

gggcccatgg tcctgcagac tcaggtgttc atcagcctgc tgctgtggat ttctggggcc     1560

tacggcagtt atgtgctgac acagcctcca agcgtctccg tggctcctgg cgaaactgca     1620

cgaatctcct gtggagggaa caatattggg actaaggtgc tgcattggta ccagcagacc     1680

ccaggacagg ctccagtgct ggtcgtgtat gacgatagtg acagaccttc aggcatcccc     1740

gagcggttct ctggaagtaa ctcagggaat accgccacac tgactatttc ccgcgtcgaa     1800

gtgggcgacg aagctgatta ctattgccaa gtgtgggaca tctctaccga tcaggccgtc     1860

ttcggcggag ggactaagct gaccgtgctg ggccagccca aagctgcacc ttccgtgaca     1920

ctgtttcccc ctagttcaga ggaactgcag gctaacaagg caaccctggt gtgtctgatt     1980

agcgacttct acccaggagc agtcacagtg gcatggaagg ctgatagctc ccctgtcaaa     2040

gccggcgtgg aaactaccac accatctaag cagagtaaca acaagtacgc cgcttctagt     2100

tatctgagcc tgacacctga gcagtggaag tcccacagga gctattcctg ccaagtgact     2160

catgagggca gtactgtcga aaaaaccgtg gccccaacag agtgtagctg ataa           2214


<210>  166
<211>  2238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  166
atggactgga cttggaggat tctgtttctg gtcgccgccg ctactgggac acacgctcag       60

gtgcagctgg tcgagagtgg ggggggagtg gtccagccag ggcgatctct gaggctgagt      120

tgcgccgctt caggcttcac cttcagcact tacgcaatgc actgggtgcg gcaggctcca      180

ggaaagggac tggagtgggt cgccgtgatc tcttacgacg ctaactataa gtactatgca      240

gatagtgtga aaggcagatt caccattagc cgggacaact ccaagaatac actgtacctg      300

cagatgaatt ccctgcgagc agaagacacc gccgtgtact attgcgccaa agattctcag      360

ctgcgcagtc tgctgtattt cgagtggctg tctcaggggt actttgacta ttggggccag      420

ggaaccctgg tcacagtgag ctccgccagt accaagggcc catcagtgtt tcctctggct      480

ccatctagta aatctacaag tggcggaact gcagccctgg gctgtctggt gaaggattac      540

ttcccagagc ccgtcacagt gtcctggaac tctggagctc tgacttccgg ggtgcatacc      600

tttcctgcag tcctgcagtc aagcgggctg tactctctgt cctctgtggt caccgtgcca      660

agttcaagcc tgggcactca gacctatatc tgcaacgtga atcacaagcc ttccaataca      720

aaagtcgaca agaaagtgga accaaagtct tgtgataaaa cacatacttg ccccccttgt      780

cctgctccag agctgctggg aggaccaagc gtgttcctgt ttccacccaa gcccaaagac      840

accctgatga ttagcaggac cccagaagtg acatgtgtgg tcgtggacgt cagccacgag      900

gaccccgaag tgaagttcaa ctggtacgtg gatggcgtcg aggtgcataa tgccaagaca      960

aaacctaggg aggaacagta caacagcact tatagagtcg tgtccgtcct gaccgtgctg     1020

caccaggact ggctgaacgg aaaggagtat aagtgcaaag tgtccaataa ggccctgccc     1080

gctcctatcg agaaaaccat ttctaaggct aaagggcagc cccgggaacc tcaggtgtac     1140

acactgcctc caagccgcga cgagctgacc aagaaccagg tgtccctgac atgtctggtc     1200

aaaggcttct atcccagtga tatcgccgtg gagtgggaat caaatggaca gcctgaaaac     1260

aattacaaga ccacaccccc tgtgctggac agtgatggct cattctttct gtattcaaag     1320

ctgaccgtgg acaaaagccg gtggcagcag ggaaacgtct tttcatgcag cgtgatgcat     1380

gaggctctgc acaatcatta cactcagaag tccctgtctc tgagtcccgg caagcgggga     1440

cgcaaaagga gatcagggag cggcgctaca aacttctccc tgctgaagca ggcaggcgat     1500

gtggaggaaa atccaggacc catggtcctg cagacacagg tgtttatctc tctgctgctg     1560

tggattagtg gggcctatgg cgacatcgtg atgactcaga gccctgattc cctggcagtg     1620

agcctgggag agcgagcaac aattaactgt aagtcctctc agagcgtgac tttcaactac     1680

aaaaattatc tggcatggta ccagcagaag cccggacagc cacccaaact gctgatctat     1740

tgggcctcaa ctcgcgaaag cggggtgcct gaccgattct ccggatctgg gagtggcacc     1800

gattttaccc tgacaattag ttcactgcag gctgaggacg tcgcagtgta ctattgccag     1860

cagcactaca ggactcctcc aaccttcgga caggggacaa aggtcgaaat caaaactgtg     1920

gctgcacctt ccgtcttcat ttttccccct tctgacgagc agctgaagtc cggcaccgcc     1980

tctgtcgtgt gtctgctgaa caatttttac ccaagagaag ccaaggtcca gtggaaagtg     2040

gataacgctc tgcagtctgg aaatagtcag gagtcagtga cagaacagga cagcaaggat     2100

tccacttatt cactgagcaa cactctgacc ctgagcaaag cagattacga gaagcacaaa     2160

gtgtatgcct gcgaagtcac tcatcaggga ctgagctccc ccgtgaccaa gagctttaat     2220

agaggggagt gttgataa                                                   2238


<210>  167
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  167
atggattgga cttggaggat tctgtttctg gtcgccgccg ctactggaac tcacgctcag       60

gtgcagctgc agcagtctgg acccggactg gtgaagcctt cacagactct gagcctgacc      120

tgcgccatct ccggcgactc tgtgagctcc aacaatgctg tctggaactg gattagacag      180

tccccatctc gggggctgga atggctggga cgaacatact ataggagcaa atggtacaat      240

gactatgctg agagtgtgaa gtcacgaatc acaattaacc cagatactag caagaatcag      300

ttctccctgc agctgaactc tgtgacaccc gaggatactg cagtctacta ttgcgcacgc      360

tccggacaca tcaccgtgtt cggagtcaat gtggacgcct ttgatatgtg gggacagggg      420

accacagtca cagtgtctag tgcaagtact aaaggcccat cagtgtttcc cctggcccct      480

tcaagcaaga gtacctcagg cggaacagcc gctctgggat gtctggtgaa ggactacttc      540

cctgagccag tcaccgtgag ctggaactcc ggagctctga ccagcggggt gcatacattt      600

cctgcagtcc tgcagtcctc tggcctgtac agcctgagtt cagtggtcac cgtgccaagc      660

tcctctctgg gaacacagac ttatatctgc aacgtgaatc acaaaccatc caatacaaag      720

gtcgacaaga aagtggaacc caaatcttgt gataagaccc atacatgccc tccctgtcca      780

gcacctgagc tgctgggcgg cccatccgtg ttcctgtttc cacccaagcc taaagacaca      840

ctgatgatta gccggactcc cgaagtgacc tgcgtggtcg tggacgtgag ccacgaggac      900

cccgaagtga agttcaactg gtacgtggat ggcgtcgagg tgcataatgc caagaccaaa      960

cctagggagg aacagtacaa cagcacttat agagtcgtgt ccgtcctgac cgtgctgcac     1020

caggattggc tgaacgggaa ggagtataag tgcaaagtgt ccaacaaggc cctgccagct     1080

cccatcgaga agaccatttc taaggccaaa ggccagccac gggaacccca ggtgtacaca     1140

ctgcctccaa gccgcgacga gctgaccaaa aaccaggtga gcctgacatg tctggtcaag     1200

ggattctatc ctagtgatat cgctgtggag tgggaatcta atgggcagcc agaaaacaat     1260

tacaagacta cccctcccgt gctggactct gatggaagtt tctttctgta ttcaaaactg     1320

accgtggaca agagccgctg gcagcagggg aacgtcttta gctgctccgt gatgcacgag     1380

gccctgcaca atcattacac tcagaaatct ctgagtctgt cacccggaaa atgataa        1437


<210>  168
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  168
atggtcctgc agacacaggt gtttatctct ctgctgctgt ggattagtgg cgcttacgga       60

gacatccaga tgactcagtc tcctagttca ctgtctgcaa gtgtcggcga tcgcgtgact      120

attacctgtc gaacctcaca gagcctgagc tcctacctgc attggtatca gcagaagcct      180

gggaaagcac caaagctgct gatctatgca gcctctagtc tgcagtccgg cgtgccctct      240

aggttctccg ggtctggcag tggaactgac tttacactga ctatttcaag cctgcagcct      300

gaggatttcg ctacctacta ttgccagcag agcagaactt ttgggcaggg caccaaagtc      360

gaaatcaaga cagtggctgc accatccgtc ttcatttttc caccctctga cgagcagctg      420

aagagtggaa ctgcctcagt ggtgtgcctg ctgaacaatt tctacccccg ggaagccaaa      480

gtccagtgga aggtggataa cgctctgcag tcaggcaata gccaggagtc cgtgacagaa      540

caggactcta aagatagtac ttattcactg agcaacaccc tgacactgag caaggcagac      600

tacgagaagc acaaagtgta tgcctgcgaa gtgacccacc aggggctgag cagtccagtg      660

accaaatctt tcaacagggg agaatgttga taa                                   693


<210>  169
<211>  1437
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  169
atggattgga catggaggat tctgtttctg gtcgccgccg caactggaac tcacgctcag       60

gtgcagctgc agcagtcagg gcctggcctg gtgaagccca gccagaccct gtccctgaca      120

tgcgccatct ccggcgactc tgtgagctcc aacaatgccg tgtggaactg gatcaggcag      180

tccccttctc gcggcctgga gtggctggga aggacctact atagaagcaa gtggtacaat      240

gactatgccg agagcgtgaa gtccaggatc accatcaacc cagatacatc taagaatcag      300

ttcagcctgc agctgaactc cgtgaccccc gaggatacag ccgtgtacta ttgcgccaga      360

tccggccaca tcaccgtgtt cggcgtgaat gtggacgcct ttgatatgtg gggccagggc      420

accacagtga ccgtgtctag cgcctctaca aagggcccaa gcgtgtttcc actggcaccc      480

tcctctaaga gcacctccgg cggcacagcc gccctgggct gtctggtgaa ggactacttc      540

ccagagcccg tgaccgtgtc ttggaacagc ggcgccctga ccagcggagt gcacacattt      600

cctgccgtgc tgcagagctc cggcctgtac tccctgtcta gcgtggtgac cgtgccatcc      660

tctagcctgg gcacccagac atatatctgc aacgtgaatc acaagccaag caatacaaag      720

gtggacaaga aggtggagcc caagtcctgt gataagaccc acacatgccc tccctgtcct      780

gcaccagagc tgctgggcgg cccaagcgtg ttcctgtttc cacccaagcc taaggacacc      840

ctgatgatct ctcggacccc cgaggtgaca tgcgtggtgg tggacgtgag ccacgaggac      900

cccgaggtga agttcaactg gtacgtggat ggcgtggagg tgcacaatgc caagacaaag      960

cctagggagg agcagtacaa ctccacctat agagtggtgt ctgtgctgac agtgctgcac     1020

caggattggc tgaacggcaa ggagtataag tgcaaggtgt ccaataaggc cctgcccgcc     1080

cctatcgaga agaccatctc taaggcaaag ggacagcctc gggagccaca ggtgtacaca     1140

ctgcctccat cccgcgacga gctgaccaag aaccaggtgt ctctgacatg tctggtgaag     1200

ggcttctatc cttctgatat cgccgtggag tgggagagca atggccagcc agagaacaat     1260

tacaagacca caccccctgt gctggactcc gatggctctt tctttctgta tagcaagctg     1320

accgtggaca agtcccgctg gcagcagggc aacgtgtttt cttgtagcgt gatgcacgaa     1380

gcactgcaca accattacac ccagaagtca ctgtcactgt ccccaggaaa atgataa        1437


<210>  170
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Influenza A DMAb

<400>  170
atggtgctgc agacccaggt gtttatttcc ctgctgctgt ggattagcgg cgcatacggc       60

gacattcaga tgactcagag cccttcaagc ctgtccgcct ctgtgggcga cagggtgacc      120

atcacatgca gaaccagcca gtccctgagc tcctacctgc actggtatca gcagaagcca      180

ggcaaggccc ccaagctgct gatctacgca gcctctagcc tgcagagcgg cgtgccttcc      240

cggttctctg gcagcggctc cggcaccgac tttaccctga caatctcctc tctgcagcca      300

gaggatttcg ccacatacta ttgccagcag tcccgcacct ttggccaggg cacaaaggtg      360

gagatcaaga ccgtggccgc cccctccgtg ttcatctttc ccccttctga cgagcagctg      420

aagtctggca cagccagcgt ggtgtgcctg ctgaacaatt tctaccctag ggaggccaag      480

gtgcagtgga aggtggataa cgccctgcag tccggcaatt ctcaggagag cgtgaccgag      540

caggactcca aggattctac atattctctg agcaacaccc tgacactgag caaggccgat      600

tacgagaagc acaaggtgta tgcctgtgag gtcactcacc aggggctgtc atcacccgtc      660

accaaatcct ttaatagggg agaatgttga taa                                   693


<210>  171
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amyloid beta  (X-Y) peptide

<400>  171

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile 
        35                  40                  45          


