                         SEQUENCE LISTING

<110>  Lallemand Inc.
 
<120>  OPTIMIZED YEAST HOST CELLS FOR THE PRODUCTION OF GLUTATHIONE

<130>  55729550-8PCT

<150>  US 62/315,796
<151>  2016-03-31

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  507
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Thr Lys Ser Glu Gln Gln Ala Asp Ser Arg His Asn Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Lys Pro Gln Ile Tyr Ala Lys Leu Glu Leu Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Met Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Glu Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Leu 
        195                 200                 205             


Lys Glu Gln Asn Asp Lys Ile Gln Ile Val Gly Ala Asp Pro Phe Gly 
    210                 215                 220                 


Ser Ile Leu Ala Gln Pro Glu Asn Leu Asn Lys Thr Asp Ile Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Val Pro Gln Val Leu Asp 
                245                 250                 255     


Arg Lys Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Thr Ala Val Val Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asn Leu Trp Asp Asp Asp Val Leu Ala Arg Phe Asp Ser Ser Lys 
            340                 345                 350         


Leu Glu Ala Ser Thr Thr Lys Tyr Ala Asp Val Phe Gly Asn Ala Thr 
        355                 360                 365             


Val Lys Asp Leu His Leu Lys Pro Val Val Ser Val Lys Glu Thr Ala 
    370                 375                 380                 


Lys Val Thr Asp Val Ile Lys Ile Leu Lys Asp Asn Gly Phe Asp Gln 
385                 390                 395                 400 


Leu Pro Val Leu Thr Glu Asp Gly Lys Leu Ser Gly Leu Val Thr Leu 
                405                 410                 415     


Ser Glu Leu Leu Arg Lys Leu Ser Ile Asn Asn Ser Asn Asn Asp Asn 
            420                 425                 430         


Thr Ile Lys Gly Lys Tyr Leu Asp Phe Lys Lys Leu Asn Asn Phe Asn 
        435                 440                 445             


Asp Val Ser Ser Tyr Asn Glu Asn Lys Ser Gly Lys Lys Lys Phe Ile 
    450                 455                 460                 


Lys Phe Asp Glu Asn Ser Lys Leu Ser Asp Leu Asn Arg Phe Phe Glu 
465                 470                 475                 480 


Lys Asn Ser Ser Ala Val Ile Thr Asp Gly Leu Lys Pro Ile His Ile 
                485                 490                 495     


Val Thr Lys Met Asp Leu Leu Ser Tyr Leu Ala 
            500                 505         


<210>  2
<211>  353
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated CYS4p

<400>  2

Met Thr Lys Ser Glu Gln Gln Ala Asp Ser Arg His Asn Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Lys Pro Gln Ile Tyr Ala Lys Leu Glu Leu Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Met Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Glu Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Leu 
        195                 200                 205             


Lys Glu Gln Asn Asp Lys Ile Gln Ile Val Gly Ala Asp Pro Phe Gly 
    210                 215                 220                 


Ser Ile Leu Ala Gln Pro Glu Asn Leu Asn Lys Thr Asp Ile Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Val Pro Gln Val Leu Asp 
                245                 250                 255     


Arg Lys Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Thr Ala Val Val Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asn Leu Trp Asp Asp Asp Val Leu Ala Arg Phe Asp Ser Ser Lys 
            340                 345                 350         


Leu 
    


<210>  3
<211>  656
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Ser Val Ser Thr Ala Lys Arg Ser Leu Asp Val Val Ser Pro Gly 
1               5                   10                  15      


Ser Leu Ala Glu Phe Glu Gly Ser Lys Ser Arg His Asp Glu Ile Glu 
            20                  25                  30          


Asn Glu His Arg Arg Thr Gly Thr Arg Asp Gly Glu Asp Ser Glu Gln 
        35                  40                  45              


Pro Lys Lys Lys Gly Ser Lys Thr Ser Lys Lys Gln Asp Leu Asp Pro 
    50                  55                  60                  


Glu Thr Lys Gln Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala 
65                  70                  75                  80  


Phe Arg Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Lys Lys Val 
                85                  90                  95      


Gln Ser Leu Glu Ser Ile Gln Gln Gln Asn Glu Val Glu Ala Thr Phe 
            100                 105                 110         


Leu Arg Asp Gln Leu Ile Thr Leu Val Asn Glu Leu Lys Lys Tyr Arg 
        115                 120                 125             


Pro Glu Thr Arg Asn Asp Ser Lys Val Leu Glu Tyr Leu Ala Arg Arg 
    130                 135                 140                 


Asp Pro Asn Leu Leu Phe Ser Lys Asn Asn Val Asn His Ser Asn Ser 
145                 150                 155                 160 


Glu Pro Ile Asp Thr Pro Asn Asp Asp Ile Gln Glu Asn Val Lys Gln 
                165                 170                 175     


Lys Met Asn Phe Thr Phe Gln Tyr Pro Leu Asp Asn Asp Asn Asp Asn 
            180                 185                 190         


Asp Asp Ser Lys Asn Val Gly Lys Gln Leu Pro Ser Pro Asn Asp Pro 
        195                 200                 205             


Ser His Ser Ala Pro Met Pro Ile Asn Gln Thr Gln Lys Lys Leu Ser 
    210                 215                 220                 


Asp Ala Thr Asp Ser Ser Ser Ala Thr Leu Asp Ser Leu Ser Asn Ser 
225                 230                 235                 240 


Asn Asp Val Leu Asn Asn Thr Pro Asn Ser Ser Thr Ser Met Asp Trp 
                245                 250                 255     


Leu Asp Asn Val Ile Tyr Thr Asn Arg Phe Val Ser Gly Asp Asp Gly 
            260                 265                 270         


Ser Asn Ser Lys Thr Lys Asn Leu Asp Ser Asn Met Phe Ser Asn Asp 
        275                 280                 285             


Phe Asn Phe Glu Asn Gln Phe Asp Glu Gln Val Ser Glu Phe Cys Ser 
    290                 295                 300                 


Lys Met Asn Gln Val Cys Gly Thr Arg Gln Cys Pro Ile Pro Lys Lys 
305                 310                 315                 320 


Pro Ile Ser Ala Leu Asp Lys Glu Val Phe Ala Ser Ser Ser Ile Leu 
                325                 330                 335     


Ser Ser Asn Ser Pro Ala Leu Thr Asn Thr Trp Glu Ser His Ser Asn 
            340                 345                 350         


Ile Thr Asp Asn Thr Pro Ala Asn Val Ile Ala Thr Asp Ala Thr Lys 
        355                 360                 365             


Tyr Glu Asn Ser Phe Ser Gly Phe Gly Arg Leu Gly Phe Asp Met Ser 
    370                 375                 380                 


Ala Asn His Tyr Val Val Asn Asp Asn Ser Thr Gly Ser Thr Asp Ser 
385                 390                 395                 400 


Thr Asp Ser Thr Gly Ser Thr Gly Ser Thr Gly Asn Lys Asn Lys Lys 
                405                 410                 415     


Asn Asn Asn Asn Ser Asp Asp Val Leu Pro Phe Ile Ser Glu Ser Pro 
            420                 425                 430         


Phe Asp Met Asn Gln Val Thr Asn Phe Phe Ser Pro Gly Ser Thr Gly 
        435                 440                 445             


Ile Gly Asn Asn Ala Ala Ser Asn Thr Asn Pro Ser Leu Leu Gln Ser 
    450                 455                 460                 


Ser Lys Glu Asp Ile Pro Phe Ile Asn Ala Asn Leu Ala Phe Pro Asp 
465                 470                 475                 480 


Asp Asn Ser Thr Asn Ile Gln Leu Gln Pro Phe Ser Glu Ser Gln Ser 
                485                 490                 495     


Gln Asn Lys Phe Asp Tyr Asp Met Phe Phe Arg Asp Ser Ser Lys Glu 
            500                 505                 510         


Gly Asn Asn Leu Phe Gly Glu Phe Leu Glu Asp Asp Asp Asp Asp Lys 
        515                 520                 525             


Lys Ala Ala Asn Met Ser Asp Asp Glu Ser Ser Leu Ile Lys Asn Gln 
    530                 535                 540                 


Leu Ile Asn Glu Glu Pro Glu Leu Pro Lys Gln Tyr Leu Gln Ser Val 
545                 550                 555                 560 


Pro Gly Asn Glu Ser Glu Ile Ser Gln Lys Asn Gly Ser Ser Leu Gln 
                565                 570                 575     


Asn Ala Asp Lys Ile Asn Asn Gly Asn Asp Asn Asp Asn Asp Asn Asp 
            580                 585                 590         


Val Val Pro Ser Lys Glu Gly Ser Leu Leu Arg Cys Ser Glu Ile Trp 
        595                 600                 605             


Asp Arg Ile Thr Thr His Pro Lys Tyr Ser Asp Ile Asp Val Asp Gly 
    610                 615                 620                 


Leu Cys Ser Glu Leu Met Ala Lys Ala Lys Cys Ser Glu Arg Gly Val 
625                 630                 635                 640 


Val Ile Asn Ala Glu Asp Val Gln Leu Ala Leu Asn Lys His Met Asn 
                645                 650                 655     


<210>  4
<211>  656
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated YAP1p


<220>
<221>  VARIANT
<222>  (626)..(626)
<223>  Xaa can be Asp, Leu, Arg, His, Glu, Ser, Thr, Asn, Gln, Lys, Ser,
       Tyr, Met or Trp

<400>  4

Met Ser Val Ser Thr Ala Lys Arg Ser Leu Asp Val Val Ser Pro Gly 
1               5                   10                  15      


Ser Leu Ala Glu Phe Glu Gly Ser Lys Ser Arg His Asp Glu Ile Glu 
            20                  25                  30          


Asn Glu His Arg Arg Thr Gly Thr Arg Asp Gly Glu Asp Ser Glu Gln 
        35                  40                  45              


Pro Lys Lys Lys Gly Ser Lys Thr Ser Lys Lys Gln Asp Leu Asp Pro 
    50                  55                  60                  


Glu Thr Lys Gln Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala 
65                  70                  75                  80  


Phe Arg Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Lys Lys Val 
                85                  90                  95      


Gln Ser Leu Glu Ser Ile Gln Gln Gln Asn Glu Val Glu Ala Thr Phe 
            100                 105                 110         


Leu Arg Asp Gln Leu Ile Thr Leu Val Asn Glu Leu Lys Lys Tyr Arg 
        115                 120                 125             


Pro Glu Thr Arg Asn Asp Ser Lys Val Leu Glu Tyr Leu Ala Arg Arg 
    130                 135                 140                 


Asp Pro Asn Leu Leu Phe Ser Lys Asn Asn Val Asn His Ser Asn Ser 
145                 150                 155                 160 


Glu Pro Ile Asp Thr Pro Asn Asp Asp Ile Gln Glu Asn Val Lys Gln 
                165                 170                 175     


Lys Met Asn Phe Thr Phe Gln Tyr Pro Leu Asp Asn Asp Asn Asp Asn 
            180                 185                 190         


Asp Asp Ser Lys Asn Val Gly Lys Gln Leu Pro Ser Pro Asn Asp Pro 
        195                 200                 205             


Ser His Ser Ala Pro Met Pro Ile Asn Gln Thr Gln Lys Lys Leu Ser 
    210                 215                 220                 


Asp Ala Thr Asp Ser Ser Ser Ala Thr Leu Asp Ser Leu Ser Asn Ser 
225                 230                 235                 240 


Asn Asp Val Leu Asn Asn Thr Pro Asn Ser Ser Thr Ser Met Asp Trp 
                245                 250                 255     


Leu Asp Asn Val Ile Tyr Thr Asn Arg Phe Val Ser Gly Asp Asp Gly 
            260                 265                 270         


Ser Asn Ser Lys Thr Lys Asn Leu Asp Ser Asn Met Phe Ser Asn Asp 
        275                 280                 285             


Phe Asn Phe Glu Asn Gln Phe Asp Glu Gln Val Ser Glu Phe Cys Ser 
    290                 295                 300                 


Lys Met Asn Gln Val Cys Gly Thr Arg Gln Cys Pro Ile Pro Lys Lys 
305                 310                 315                 320 


Pro Ile Ser Ala Leu Asp Lys Glu Val Phe Ala Ser Ser Ser Ile Leu 
                325                 330                 335     


Ser Ser Asn Ser Pro Ala Leu Thr Asn Thr Trp Glu Ser His Ser Asn 
            340                 345                 350         


Ile Thr Asp Asn Thr Pro Ala Asn Val Ile Ala Thr Asp Ala Thr Lys 
        355                 360                 365             


Tyr Glu Asn Ser Phe Ser Gly Phe Gly Arg Leu Gly Phe Asp Met Ser 
    370                 375                 380                 


Ala Asn His Tyr Val Val Asn Asp Asn Ser Thr Gly Ser Thr Asp Ser 
385                 390                 395                 400 


Thr Asp Ser Thr Gly Ser Thr Gly Ser Thr Gly Asn Lys Asn Lys Lys 
                405                 410                 415     


Asn Asn Asn Asn Ser Asp Asp Val Leu Pro Phe Ile Ser Glu Ser Pro 
            420                 425                 430         


Phe Asp Met Asn Gln Val Thr Asn Phe Phe Ser Pro Gly Ser Thr Gly 
        435                 440                 445             


Ile Gly Asn Asn Ala Ala Ser Asn Thr Asn Pro Ser Leu Leu Gln Ser 
    450                 455                 460                 


Ser Lys Glu Asp Ile Pro Phe Ile Asn Ala Asn Leu Ala Phe Pro Asp 
465                 470                 475                 480 


Asp Asn Ser Thr Asn Ile Gln Leu Gln Pro Phe Ser Glu Ser Gln Ser 
                485                 490                 495     


Gln Asn Lys Phe Asp Tyr Asp Met Phe Phe Arg Asp Ser Ser Lys Glu 
            500                 505                 510         


Gly Asn Asn Leu Phe Gly Glu Phe Leu Glu Asp Asp Asp Asp Asp Lys 
        515                 520                 525             


Lys Ala Ala Asn Met Ser Asp Asp Glu Ser Ser Leu Ile Lys Asn Gln 
    530                 535                 540                 


Leu Ile Asn Glu Glu Pro Glu Leu Pro Lys Gln Tyr Leu Gln Ser Val 
545                 550                 555                 560 


Pro Gly Asn Glu Ser Glu Ile Ser Gln Lys Asn Gly Ser Ser Leu Gln 
                565                 570                 575     


Asn Ala Asp Lys Ile Asn Asn Gly Asn Asp Asn Asp Asn Asp Asn Asp 
            580                 585                 590         


Val Val Pro Ser Lys Glu Gly Ser Leu Leu Arg Cys Ser Glu Ile Trp 
        595                 600                 605             


Asp Arg Ile Thr Thr His Pro Lys Tyr Ser Asp Ile Asp Val Asp Gly 
    610                 615                 620                 


Leu Xaa Ser Glu Leu Met Ala Lys Ala Lys Cys Ser Glu Arg Gly Val 
625                 630                 635                 640 


Val Ile Asn Ala Glu Asp Val Gln Leu Ala Leu Asn Lys His Met Asn 
                645                 650                 655     


<210>  5
<211>  656
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated YAP1p

<400>  5

Met Ser Val Ser Thr Ala Lys Arg Ser Leu Asp Val Val Ser Pro Gly 
1               5                   10                  15      


Ser Leu Ala Glu Phe Glu Gly Ser Lys Ser Arg His Asp Glu Ile Glu 
            20                  25                  30          


Asn Glu His Arg Arg Thr Gly Thr Arg Asp Gly Glu Asp Ser Glu Gln 
        35                  40                  45              


Pro Lys Lys Lys Gly Ser Lys Thr Ser Lys Lys Gln Asp Leu Asp Pro 
    50                  55                  60                  


Glu Thr Lys Gln Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala 
65                  70                  75                  80  


Phe Arg Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Lys Lys Val 
                85                  90                  95      


Gln Ser Leu Glu Ser Ile Gln Gln Gln Asn Glu Val Glu Ala Thr Phe 
            100                 105                 110         


Leu Arg Asp Gln Leu Ile Thr Leu Val Asn Glu Leu Lys Lys Tyr Arg 
        115                 120                 125             


Pro Glu Thr Arg Asn Asp Ser Lys Val Leu Glu Tyr Leu Ala Arg Arg 
    130                 135                 140                 


Asp Pro Asn Leu Leu Phe Ser Lys Asn Asn Val Asn His Ser Asn Ser 
145                 150                 155                 160 


Glu Pro Ile Asp Thr Pro Asn Asp Asp Ile Gln Glu Asn Val Lys Gln 
                165                 170                 175     


Lys Met Asn Phe Thr Phe Gln Tyr Pro Leu Asp Asn Asp Asn Asp Asn 
            180                 185                 190         


Asp Asp Ser Lys Asn Val Gly Lys Gln Leu Pro Ser Pro Asn Asp Pro 
        195                 200                 205             


Ser His Ser Ala Pro Met Pro Ile Asn Gln Thr Gln Lys Lys Leu Ser 
    210                 215                 220                 


Asp Ala Thr Asp Ser Ser Ser Ala Thr Leu Asp Ser Leu Ser Asn Ser 
225                 230                 235                 240 


Asn Asp Val Leu Asn Asn Thr Pro Asn Ser Ser Thr Ser Met Asp Trp 
                245                 250                 255     


Leu Asp Asn Val Ile Tyr Thr Asn Arg Phe Val Ser Gly Asp Asp Gly 
            260                 265                 270         


Ser Asn Ser Lys Thr Lys Asn Leu Asp Ser Asn Met Phe Ser Asn Asp 
        275                 280                 285             


Phe Asn Phe Glu Asn Gln Phe Asp Glu Gln Val Ser Glu Phe Cys Ser 
    290                 295                 300                 


Lys Met Asn Gln Val Cys Gly Thr Arg Gln Cys Pro Ile Pro Lys Lys 
305                 310                 315                 320 


Pro Ile Ser Ala Leu Asp Lys Glu Val Phe Ala Ser Ser Ser Ile Leu 
                325                 330                 335     


Ser Ser Asn Ser Pro Ala Leu Thr Asn Thr Trp Glu Ser His Ser Asn 
            340                 345                 350         


Ile Thr Asp Asn Thr Pro Ala Asn Val Ile Ala Thr Asp Ala Thr Lys 
        355                 360                 365             


Tyr Glu Asn Ser Phe Ser Gly Phe Gly Arg Leu Gly Phe Asp Met Ser 
    370                 375                 380                 


Ala Asn His Tyr Val Val Asn Asp Asn Ser Thr Gly Ser Thr Asp Ser 
385                 390                 395                 400 


Thr Asp Ser Thr Gly Ser Thr Gly Ser Thr Gly Asn Lys Asn Lys Lys 
                405                 410                 415     


Asn Asn Asn Asn Ser Asp Asp Val Leu Pro Phe Ile Ser Glu Ser Pro 
            420                 425                 430         


Phe Asp Met Asn Gln Val Thr Asn Phe Phe Ser Pro Gly Ser Thr Gly 
        435                 440                 445             


Ile Gly Asn Asn Ala Ala Ser Asn Thr Asn Pro Ser Leu Leu Gln Ser 
    450                 455                 460                 


Ser Lys Glu Asp Ile Pro Phe Ile Asn Ala Asn Leu Ala Phe Pro Asp 
465                 470                 475                 480 


Asp Asn Ser Thr Asn Ile Gln Leu Gln Pro Phe Ser Glu Ser Gln Ser 
                485                 490                 495     


Gln Asn Lys Phe Asp Tyr Asp Met Phe Phe Arg Asp Ser Ser Lys Glu 
            500                 505                 510         


Gly Asn Asn Leu Phe Gly Glu Phe Leu Glu Asp Asp Asp Asp Asp Lys 
        515                 520                 525             


Lys Ala Ala Asn Met Ser Asp Asp Glu Ser Ser Leu Ile Lys Asn Gln 
    530                 535                 540                 


Leu Ile Asn Glu Glu Pro Glu Leu Pro Lys Gln Tyr Leu Gln Ser Val 
545                 550                 555                 560 


Pro Gly Asn Glu Ser Glu Ile Ser Gln Lys Asn Gly Ser Ser Leu Gln 
                565                 570                 575     


Asn Ala Asp Lys Ile Asn Asn Gly Asn Asp Asn Asp Asn Asp Asn Asp 
            580                 585                 590         


Val Val Pro Ser Lys Glu Gly Ser Leu Leu Arg Cys Ser Glu Ile Trp 
        595                 600                 605             


Asp Arg Ile Thr Thr His Pro Lys Tyr Ser Asp Ile Asp Val Asp Gly 
    610                 615                 620                 


Leu Asp Ser Glu Leu Met Ala Lys Ala Lys Cys Ser Glu Arg Gly Val 
625                 630                 635                 640 


Val Ile Asn Ala Glu Asp Val Gln Leu Ala Leu Asn Lys His Met Asn 
                645                 650                 655     


<210>  6
<211>  507
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Thr Lys Ser Glu Gln Gln Ala Asp Ser Arg His Asn Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Lys Pro Gln Ile Tyr Ala Lys Leu Glu Leu Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Met Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Glu Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Leu 
        195                 200                 205             


Lys Glu Gln Asn Asp Lys Ile Gln Ile Val Gly Ala Asp Pro Phe Gly 
    210                 215                 220                 


Ser Ile Leu Ala Gln Pro Glu Asn Leu Asn Lys Thr Asp Ile Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Val Pro Gln Val Leu Asp 
                245                 250                 255     


Arg Lys Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Thr Ala Val Val Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asn Leu Trp Asp Asp Asp Val Leu Ala Arg Phe Asp Ser Ser Lys 
            340                 345                 350         


Leu Glu Ala Ser Thr Thr Lys Tyr Ala Asp Val Phe Gly Asn Ala Thr 
        355                 360                 365             


Val Lys Asp Leu His Leu Lys Pro Val Val Ser Val Lys Glu Thr Ala 
    370                 375                 380                 


Lys Val Thr Asp Val Ile Lys Ile Leu Lys Asp Asn Gly Phe Asp Gln 
385                 390                 395                 400 


Leu Pro Val Leu Thr Glu Asp Gly Lys Leu Ser Gly Leu Val Thr Leu 
                405                 410                 415     


Ser Glu Leu Leu Arg Lys Leu Ser Ile Asn Asn Ser Asn Asn Asp Asn 
            420                 425                 430         


Thr Ile Lys Gly Lys Tyr Leu Asp Phe Lys Lys Leu Asn Asn Phe Asn 
        435                 440                 445             


Asp Val Ser Ser Tyr Asn Glu Asn Lys Ser Gly Lys Lys Lys Phe Ile 
    450                 455                 460                 


Lys Phe Asp Glu Asn Ser Lys Leu Ser Asp Leu Asn Arg Phe Phe Glu 
465                 470                 475                 480 


Lys Asn Ser Ser Ala Val Ile Thr Asp Gly Leu Lys Pro Ile His Ile 
                485                 490                 495     


Val Thr Lys Met Asp Leu Leu Ser Tyr Leu Ala 
            500                 505         


<210>  7
<211>  656
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Ser Val Ser Thr Ala Lys Arg Ser Leu Asp Val Val Ser Pro Gly 
1               5                   10                  15      


Ser Leu Ala Glu Phe Glu Gly Ser Lys Ser Arg His Asp Glu Ile Glu 
            20                  25                  30          


Asn Glu His Arg Arg Thr Gly Thr Arg Asp Gly Glu Asp Ser Glu Gln 
        35                  40                  45              


Pro Lys Lys Lys Gly Ser Lys Thr Ser Lys Lys Gln Asp Leu Asp Pro 
    50                  55                  60                  


Glu Thr Lys Gln Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala 
65                  70                  75                  80  


Phe Arg Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Lys Lys Val 
                85                  90                  95      


Gln Ser Leu Glu Ser Ile Gln Gln Gln Asn Glu Val Glu Ala Thr Phe 
            100                 105                 110         


Leu Arg Asp Gln Leu Ile Thr Leu Val Asn Glu Leu Lys Lys Tyr Arg 
        115                 120                 125             


Pro Glu Thr Arg Asn Asp Ser Lys Val Leu Glu Tyr Leu Ala Arg Arg 
    130                 135                 140                 


Asp Pro Asn Leu Leu Phe Ser Lys Asn Asn Val Asn His Ser Asn Ser 
145                 150                 155                 160 


Glu Pro Ile Asp Thr Pro Asn Asp Asp Ile Gln Glu Asn Val Lys Gln 
                165                 170                 175     


Lys Met Asn Phe Thr Phe Gln Tyr Pro Leu Asp Asn Asp Asn Asp Asn 
            180                 185                 190         


Asp Asp Ser Lys Asn Val Gly Lys Gln Leu Pro Ser Pro Asn Asp Pro 
        195                 200                 205             


Ser His Ser Ala Pro Met Pro Ile Asn Gln Thr Gln Lys Lys Leu Ser 
    210                 215                 220                 


Asp Ala Thr Asp Ser Ser Ser Ala Thr Leu Asp Ser Leu Ser Asn Ser 
225                 230                 235                 240 


Asn Asp Val Leu Asn Asn Thr Pro Asn Ser Ser Thr Ser Met Asp Trp 
                245                 250                 255     


Leu Asp Asn Val Ile Tyr Thr Asn Arg Phe Val Ser Gly Asp Asp Gly 
            260                 265                 270         


Ser Asn Ser Lys Thr Lys Asn Leu Asp Ser Asn Met Phe Ser Asn Asp 
        275                 280                 285             


Phe Asn Phe Glu Asn Gln Phe Asp Glu Gln Val Ser Glu Phe Cys Ser 
    290                 295                 300                 


Lys Met Asn Gln Val Cys Gly Thr Arg Gln Cys Pro Ile Pro Lys Lys 
305                 310                 315                 320 


Pro Ile Ser Ala Leu Asp Lys Glu Val Phe Ala Ser Ser Ser Ile Leu 
                325                 330                 335     


Ser Ser Asn Ser Pro Ala Leu Thr Asn Thr Trp Glu Ser His Ser Asn 
            340                 345                 350         


Ile Thr Asp Asn Thr Pro Ala Asn Val Ile Ala Thr Asp Ala Thr Lys 
        355                 360                 365             


Tyr Glu Asn Ser Phe Ser Gly Phe Gly Arg Leu Gly Phe Asp Met Ser 
    370                 375                 380                 


Ala Asn His Tyr Val Val Asn Asp Asn Ser Thr Gly Ser Thr Asp Ser 
385                 390                 395                 400 


Thr Asp Ser Thr Gly Ser Thr Gly Ser Thr Gly Asn Lys Asn Lys Lys 
                405                 410                 415     


Asn Asn Asn Asn Ser Asp Asp Val Leu Pro Phe Ile Ser Glu Ser Pro 
            420                 425                 430         


Phe Asp Met Asn Gln Val Thr Asn Phe Phe Ser Pro Gly Ser Thr Gly 
        435                 440                 445             


Ile Gly Asn Asn Ala Ala Ser Asn Thr Asn Pro Ser Leu Leu Gln Ser 
    450                 455                 460                 


Ser Lys Glu Asp Ile Pro Phe Ile Asn Ala Asn Leu Ala Phe Pro Asp 
465                 470                 475                 480 


Asp Asn Ser Thr Asn Ile Gln Leu Gln Pro Phe Ser Glu Ser Gln Ser 
                485                 490                 495     


Gln Asn Lys Phe Asp Tyr Asp Met Phe Phe Arg Asp Ser Ser Lys Glu 
            500                 505                 510         


Gly Asn Asn Leu Phe Gly Glu Phe Leu Glu Asp Asp Asp Asp Asp Lys 
        515                 520                 525             


Lys Ala Ala Asn Met Ser Asp Asp Glu Ser Ser Leu Ile Lys Asn Gln 
    530                 535                 540                 


Leu Ile Asn Glu Glu Pro Glu Leu Pro Lys Gln Tyr Leu Gln Ser Val 
545                 550                 555                 560 


Pro Gly Asn Glu Ser Glu Ile Ser Gln Lys Asn Gly Ser Ser Leu Gln 
                565                 570                 575     


Asn Ala Asp Lys Ile Asn Asn Gly Asn Asp Asn Asp Asn Asp Asn Asp 
            580                 585                 590         


Val Val Pro Ser Lys Glu Gly Ser Leu Leu Arg Cys Ser Glu Ile Trp 
        595                 600                 605             


Asp Arg Ile Thr Thr His Pro Lys Tyr Ser Asp Ile Asp Val Asp Gly 
    610                 615                 620                 


Leu Cys Ser Glu Leu Met Ala Lys Ala Lys Cys Ser Glu Arg Gly Val 
625                 630                 635                 640 


Val Ile Asn Ala Glu Asp Val Gln Leu Ala Leu Asn Lys His Met Asn 
                645                 650                 655     


<210>  8
<211>  419
<212>  PRT
<213>  Saccharomyces bayanus

<400>  8

Met Thr Lys Ser Glu Gln Gln Thr Asp Ser Arg His Asp Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Arg Pro Gln Ile Tyr Ala Lys Leu Glu Ile Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Val Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Pro Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Gln Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Thr Gly Ile Ala Lys Tyr Ile 
        195                 200                 205             


Lys Glu Gln Asn Glu Lys Ile Gln Ile Val Gly Ala Asp Pro Leu Gly 
    210                 215                 220                 


Ser Ile Leu Ala Val Pro Glu Asn Leu Asn Lys Thr Asp Val Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Ile Pro Asp Val Leu Asn 
                245                 250                 255     


Arg Asp Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Ala Ala Val Met Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asp Leu Trp Asp Asp Glu Ile Leu Thr Arg Phe Asp Ala Ser Lys 
            340                 345                 350         


Pro Glu Ala Ser Thr Asn Thr Tyr Ala Asp Val Phe Gly Asp Ala Thr 
        355                 360                 365             


Val Lys Asp Leu His Leu Lys Pro Val Val Ser Val Lys Glu Thr Ala 
    370                 375                 380                 


Lys Val Ala Asp Val Ile Lys Ile Leu Lys Asp Asn Gly Phe Asp Gln 
385                 390                 395                 400 


Leu Pro Val Leu Ala Glu Asp Gly Lys Leu Ser Gly Leu Val Ile Tyr 
                405                 410                 415     


Met Ser Cys 
            


<210>  9
<211>  645
<212>  PRT
<213>  Saccharomyces bayanus

<400>  9

Met Ser Ile Ser Ala Ala Lys Arg Ser Leu Asp Leu Val Ser Ser Ser 
1               5                   10                  15      


Ser Leu Ala Gln Ser Asp Asp Ser Val Ser His His Asp Glu Val Glu 
            20                  25                  30          


Asn Asp His Ile His Asp Asp Met His Asp Asn Asp Asp Asn Asp Gln 
        35                  40                  45              


Pro Arg Arg Lys Gly Ser Lys Thr Ser Lys Lys Gln Asp Leu Asp Pro 
    50                  55                  60                  


Glu Thr Lys Leu Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala 
65                  70                  75                  80  


Phe Arg Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Lys Lys Val 
                85                  90                  95      


His Ser Leu Glu Ser Ile Gln Gln Glu Asn Glu Val Glu Ala Thr Phe 
            100                 105                 110         


Leu Arg Asp Gln Leu Val Thr Leu Val Ser Glu Leu Lys Lys Tyr Arg 
        115                 120                 125             


Pro Glu Thr Arg Asn Asp Ser Lys Val Leu Glu Tyr Leu Ala Arg Arg 
    130                 135                 140                 


Asp Pro Asn Leu His Pro Pro Asn Ser Asn Thr Asn Asn Asn Ser Glu 
145                 150                 155                 160 


Pro Ile Val Thr Pro Asn Asp Asp Ile Gln Lys Asn Val Lys Gln Lys 
                165                 170                 175     


Met Asn Phe Thr Phe Gln Tyr Pro Leu Asp Asn Asp Asp Asn Asp Gly 
            180                 185                 190         


Lys Asn Met Glu Lys Gln Leu Pro Ser Pro Asn Asp Pro Asn His Ser 
        195                 200                 205             


Ala His Val Pro Ile Ala Pro Thr Gln Lys Lys Leu Ser Asp Ala Thr 
    210                 215                 220                 


Asp Ser Ser Thr Ala Thr Leu Asp Ser Phe Ser Asn Asn Asn Asp Val 
225                 230                 235                 240 


Leu Asn Ile Thr Pro Asn Ser Ser Ser Ser Met Asp Trp Leu Asp Asn 
                245                 250                 255     


Val Met Tyr Thr Asn Lys Phe Val Ala Gly Gly Asp Gln Lys Asn Ala 
            260                 265                 270         


Ser Asn Glu Ser Lys Ser Lys Pro Lys Gly Val Asp Ser Asn Met Phe 
        275                 280                 285             


Ser Asn Asp Phe Asn Phe Glu Asn Gln Phe Asp Glu Gln Val Ser Glu 
    290                 295                 300                 


Phe Cys Ser Lys Met Asn Gln Ala Cys Gly Thr Lys Gln Cys Pro Ile 
305                 310                 315                 320 


Pro Lys Lys Ser Val His Gln Leu Asp Lys Glu Val Phe Ala Ser Ser 
                325                 330                 335     


Ser Val Leu Ser Ala Asn Ser Pro Val Leu Thr Asn Thr Trp Asp Ser 
            340                 345                 350         


His Ser Asn Val Thr Thr Asn Thr Pro Ala Asn Ile Thr Thr Asn Gly 
        355                 360                 365             


Ser Ser Ser Ser Ser Phe Gly Gln Pro Gly Phe Asp Leu Asn Thr Asn 
    370                 375                 380                 


His Tyr Ala Thr Asn Asp Lys Tyr Thr Asp Asn Ser Asp Asn Asn Lys 
385                 390                 395                 400 


Thr Asn Asn Tyr Asn Asp Ile Leu Pro Phe Ile Ser Glu Ser Pro Phe 
                405                 410                 415     


Asp Met Asn Gln Val Thr Asn Phe Phe Ser Pro Gly Thr Asn Asn Thr 
            420                 425                 430         


Thr Asn Ala Asn Thr Thr Asn Ser His Asn Pro Ser Leu Gln Gln Ser 
        435                 440                 445             


Thr Lys Asp Asp Ile Pro Phe Ile Asn Thr Ser Leu Ala Phe Pro Asp 
    450                 455                 460                 


Asp Asn Pro Thr Asn Ile Gln Leu Gln Pro Leu Ser Gln Ser Gln His 
465                 470                 475                 480 


Gln Asn Lys Phe Asp Tyr Asp Met Phe Phe Arg Asp Ser Ser Lys Glu 
                485                 490                 495     


Gly Asn Asn Leu Phe Glu Glu Phe Leu Glu Glu Asp Asp Asp Asp Asp 
            500                 505                 510         


Asp Asp Asp Gly Asn Asp Gly Asn Asp Asn Asp Gly Glu Ala Val Asn 
        515                 520                 525             


Ala Ser Asp Asp Glu Ser Asn Leu Ile Lys Asn Lys Leu Ile Asn Glu 
    530                 535                 540                 


Glu Pro Gln Gln Gln Ser Gln Cys His Leu Ser Thr Pro Lys Asn Gly 
545                 550                 555                 560 


Ser Glu Val Leu Gln Asn Lys Asn Ser Ser Asn Ser Glu Asp Val Asn 
                565                 570                 575     


Asp Asn Asp Asn Glu Val Val Pro Ser Lys Glu Gly Ser Leu Leu Arg 
            580                 585                 590         


Cys Ser Glu Ile Trp Asp Arg Ile Thr Thr His Pro Lys Tyr Ser Asp 
        595                 600                 605             


Ile Asp Val Asp Gly Leu Cys Ser Glu Leu Met Ala Lys Ala Lys Cys 
    610                 615                 620                 


Ser Glu Arg Gly Val Val Ile Asn Ala Glu Asp Val Gln Leu Ala Leu 
625                 630                 635                 640 


Asn Lys His Met Asn 
                645 


<210>  10
<211>  507
<212>  PRT
<213>  Saccharomyces kudriavzevii


<220>
<221>  misc_feature
<222>  (476)..(476)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Met Thr Lys Ser Glu Gln Gln Ala Asp Ser Arg His Asn Val Ile Asp 
1               5                   10                  15      


Leu Val Gly Asn Thr Pro Leu Ile Ala Leu Lys Lys Leu Pro Lys Ala 
            20                  25                  30          


Leu Gly Ile Lys Pro Gln Ile Tyr Ala Lys Leu Glu Leu Tyr Asn Pro 
        35                  40                  45              


Gly Gly Ser Ile Lys Asp Arg Ile Ala Lys Ser Met Val Glu Glu Ala 
    50                  55                  60                  


Glu Ala Ser Gly Arg Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Ala Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Lys 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn 
145                 150                 155                 160 


Met Met Asn Pro Glu Ala His Tyr Phe Gly Thr Gly Arg Glu Ile Gln 
                165                 170                 175     


Arg Gln Leu Glu Asp Leu Asn Leu Phe Asp Asn Leu Arg Ala Val Val 
            180                 185                 190         


Ala Gly Ala Gly Thr Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Leu 
        195                 200                 205             


Lys Glu Gln Asn Asp Lys Ile Gln Ile Val Gly Ala Asp Pro Phe Gly 
    210                 215                 220                 


Ser Ile Leu Ala Gln Pro Glu Asn Leu Asn Lys Thr Asp Ile Thr Asp 
225                 230                 235                 240 


Tyr Lys Val Glu Gly Ile Gly Tyr Asp Phe Val Pro Gln Val Leu Asp 
                245                 250                 255     


Arg Lys Leu Ile Asp Val Trp Tyr Lys Thr Asp Asp Lys Pro Ser Phe 
            260                 265                 270         


Lys Tyr Ala Arg Gln Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly 
        275                 280                 285             


Ser Ser Gly Ser Ala Phe Thr Ala Val Val Lys Tyr Cys Glu Asp His 
    290                 295                 300                 


Pro Glu Leu Thr Glu Asp Asp Val Ile Val Ala Ile Phe Pro Asp Ser 
305                 310                 315                 320 


Ile Arg Ser Tyr Leu Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys 
                325                 330                 335     


Asn Asn Leu Trp Asp Asp Asp Val Leu Ala Arg Phe Asp Ser Pro Lys 
            340                 345                 350         


Leu Glu Ala Ser Thr Thr Lys Tyr Ala Asp Val Phe Gly Asn Ala Thr 
        355                 360                 365             


Val Lys Asp Leu His Leu Lys Pro Val Val Ser Val Lys Glu Thr Ala 
    370                 375                 380                 


Lys Val Thr Asp Val Ile Lys Ile Leu Lys Asp Asn Gly Phe Asp Gln 
385                 390                 395                 400 


Leu Pro Val Leu Thr Glu Asp Gly Lys Leu Ser Gly Leu Val Thr Leu 
                405                 410                 415     


Ser Glu Leu Leu Arg Lys Leu Ser Ile Asn Asn Ser Asn Asn Asp Asn 
            420                 425                 430         


Thr Ile Lys Gly Lys Tyr Leu Asp Phe Lys Lys Leu Asn Asn Phe Asn 
        435                 440                 445             


Asp Val Ser Ser Tyr Asn Glu Asn Lys Ser Gly Lys Lys Lys Phe Ile 
    450                 455                 460                 


Lys Phe Asp Glu Asn Ser Lys Leu Ser Asp Leu Xaa Arg Phe Phe Glu 
465                 470                 475                 480 


Lys Asn Ser Ser Ala Val Ile Thr Asp Gly Leu Lys Pro Ile His Ile 
                485                 490                 495     


Val Thr Lys Met Asp Leu Leu Ser Tyr Leu Ala 
            500                 505         


<210>  11
<211>  665
<212>  PRT
<213>  Saccharomyces kudriavzevii

<400>  11

Met Ser Val Ser Thr Ala Lys Arg Ser Leu Asp Leu Ala Ser Pro Gly 
1               5                   10                  15      


Ser Leu Ala Glu Phe Asp Asp Ser Ala Ala His His Asp Glu Ile Glu 
            20                  25                  30          


Asn Glu His Arg His Asp Ser Thr Arg Asp Asp Asp Asp Asn Glu Gln 
        35                  40                  45              


Pro Lys Lys Lys Gly Thr Lys Ile Ser Lys Lys Gln Asp Leu Asp Pro 
    50                  55                  60                  


Glu Thr Lys Gln Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala 
65                  70                  75                  80  


Phe Arg Glu Arg Lys Glu Arg Lys Met Met Glu Leu Glu Lys Lys Val 
                85                  90                  95      


Gln Gly Leu Glu Asn Ile Gln Gln Gln Asn Glu Val Glu Ala Thr Phe 
            100                 105                 110         


Leu Arg Asp Gln Leu Val Thr Leu Val Asn Glu Leu Lys Lys Tyr Arg 
        115                 120                 125             


Pro Glu Thr Arg Asn Asp Ser Lys Val Leu Glu Tyr Leu Ala Ser Arg 
    130                 135                 140                 


Asp Pro Asn Leu Pro Thr Ser Asn Asn Ser Thr Asn Ser Ser Ser Asn 
145                 150                 155                 160 


Arg Pro Ile Ile Thr Pro Ser Glu Glu Ile Gln Glu Asn Val Arg Gln 
                165                 170                 175     


Lys Met Asn Phe Thr Phe Gln Tyr Ala Leu Asp Asn Asp Ser Lys Asn 
            180                 185                 190         


Leu Glu Lys Gln Leu Pro Ser Pro Asn Asp Pro Ser His Ser Ala Pro 
        195                 200                 205             


Ile Pro Thr Thr Gln Ala Gln Lys Lys Ser Ser Asp Ala Thr Asp Ser 
    210                 215                 220                 


Ser Thr Ala Thr Leu Asp Ser Leu Ser Asn Ser His Asp Val Leu Asn 
225                 230                 235                 240 


Asn Thr Pro Asn Ser Ser Ser Ser Met Asp Trp Leu Asp Asn Val Ile 
                245                 250                 255     


Tyr Thr Asn Arg Phe Val Ala Gly Gly Asp Gly Ser Lys Leu Glu Val 
            260                 265                 270         


Lys Asn Val Asp Ser Asn Met Phe Ser Asn Asn Phe Asn Phe Glu Asn 
        275                 280                 285             


Gln Phe Asp Glu Gln Val Ser Glu Phe Cys Ser Lys Met Asn Gln Val 
    290                 295                 300                 


Cys Gly Thr Arg Gln Cys Pro Ile Pro Lys Lys Pro Val Ser Thr Leu 
305                 310                 315                 320 


Asp Gln Glu Val Phe Ala Ser Ser Ser Ile Leu Ser Ala Asn Ser Pro 
                325                 330                 335     


Ala Leu Thr Asn Thr Trp Glu Ser His Ser Asn Ile Thr Ala Asn Thr 
            340                 345                 350         


Pro Ala Asn Ile Thr Thr Asn Asp Thr Ser Leu Ser Gly Phe Gly Gln 
        355                 360                 365             


Leu Gly Phe Glu Leu Thr Thr Ser Arg His Ala Ala Glu Glu Asn Ser 
    370                 375                 380                 


Thr Gly Asn Thr Asp Asn Asp Asn Asn Ser Gly Asp Ser Ser Asn Asn 
385                 390                 395                 400 


Lys Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Ser Asn Asn Asn 
                405                 410                 415     


Lys Asn Asn Asn Asn Asn Gly Asp Asp Gly Gly Val Ile Pro Phe Ile 
            420                 425                 430         


Ser Asp Ser Pro Phe Asp Met Asn Gln Val Thr Asn Phe Phe Ser Pro 
        435                 440                 445             


Gly Ser Thr Asn Asn Ile Asn Ile Ala Ala Ser Ser Ala Asn Pro Ser 
    450                 455                 460                 


Leu Ser Gln Asn Thr Lys Asp Asp Val Pro Phe Ile Asn Ala Gly Leu 
465                 470                 475                 480 


Ala Phe Pro Asp Glu Asn Pro Thr Asn Ile Gln Leu Gln Pro Phe Ser 
                485                 490                 495     


Glu Ser Gln Ser Gln Asn Lys Phe Asp Tyr Asp Met Phe Phe Arg Asp 
            500                 505                 510         


Ser Ser Arg Ala Gly Asn Ser Leu Phe Glu Glu Phe Leu Glu Glu Glu 
        515                 520                 525             


Glu Asp Asp Asp Asp Asp Asp Asn Asn Asn Glu Lys Ala Thr Asn Ala 
    530                 535                 540                 


Ser Asp Asp Glu Ser Ser Leu Ile Arg Asn Gln Leu Ile Asn Glu Glu 
545                 550                 555                 560 


Pro Gln Pro Leu Asn Gln Asn Ser Leu Ser Ser Leu Asn Asn Glu Lys 
                565                 570                 575     


Glu Thr Ser Pro Lys Thr Asn Ser Gly Gly Thr Gln Asn Ala Asn Asp 
            580                 585                 590         


Ser Asp Gly Asn Asp Asn Asp Asn Asp Val Val Pro Ser Lys Glu Gly 
        595                 600                 605             


Ser Leu Leu Arg Cys Ser Glu Ile Trp Asp Arg Ile Thr Thr His Pro 
    610                 615                 620                 


Lys Tyr Ser Asp Ile Asp Val Asp Gly Leu Cys Ser Glu Leu Met Ala 
625                 630                 635                 640 


Lys Ala Lys Cys Ser Glu Arg Gly Val Val Ile Asn Ala Glu Asp Val 
                645                 650                 655     


Gln Leu Ala Leu Asn Lys His Met Asn 
            660                 665 


<210>  12
<211>  493
<212>  PRT
<213>  Candida utilis

<400>  12

Met Ser Glu Arg Asp Ser Lys Ile Pro Ala Leu Asn Glu Asn Ile Leu 
1               5                   10                  15      


Glu Leu Ile Gly Asn Thr Pro Leu Val Lys Leu Asn Lys Val Pro Gln 
            20                  25                  30          


Ser Leu Gly Ile Lys Pro Gln Val Leu Ala Lys Val Glu Leu Phe Asn 
        35                  40                  45              


Ala Gly Gly Ser Ile Lys Asp Arg Ile Ala Leu Arg Met Val Glu Glu 
    50                  55                  60                  


Ala Glu Arg Glu Gly Arg Ile Lys Pro Gly Tyr Val Leu Cys Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Ala Gly Ala Val Lys 
                85                  90                  95      


Gly Tyr Arg Val Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ser Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Asn 
        115                 120                 125             


Glu Ala Ala Phe Asp Ser Pro Glu Ser His Ile Gly Val Ala Lys Arg 
    130                 135                 140                 


Leu Glu Lys Glu Ile Lys Asn Cys Val Ile Leu Asp Gln Tyr Gly Asn 
145                 150                 155                 160 


Ile Asn Asn Pro Asp Ala His Tyr Tyr Thr Thr Gly Tyr Glu Ile Trp 
                165                 170                 175     


Lys Gln Thr Gly Gly Lys Leu Asn Ala Leu Val Ala Gly Ala Gly Thr 
            180                 185                 190         


Gly Gly Thr Ile Thr Gly Ile Ser Arg Tyr Leu Lys Glu Gln Asp Pro 
        195                 200                 205             


Ser Ile Thr Val Val Gly Ala Asp Pro Val Gly Ser Ile Leu Ala Val 
    210                 215                 220                 


Pro Glu Thr Leu Asn Lys Thr Asp Val Thr Gln Tyr Lys Val Glu Gly 
225                 230                 235                 240 


Ile Gly Tyr Asp Phe Ile Pro Asp Val Leu Lys Arg Glu Ser Val Asp 
                245                 250                 255     


Gln Trp Tyr Lys Thr Glu Asp Gln Glu Ser Phe Thr Leu Ala Arg Arg 
            260                 265                 270         


Ile Ile Ser Glu Glu Gly Ile Leu Val Gly Gly Ser Ser Gly Ser Ala 
        275                 280                 285             


Met Ala Ala Val Val Lys Tyr Cys Asn Asp His Pro Glu Leu Thr Glu 
    290                 295                 300                 


Lys Asp Thr Ile Val Val Val Phe Pro Asp Ser Ile Arg Ser Tyr Leu 
305                 310                 315                 320 


Thr Lys Phe Ala Asp Asp Glu Trp Met Lys Ser Asn Gly Phe Glu Ile 
                325                 330                 335     


Asn Thr Lys Pro Lys Ala Glu Asp Leu Gln Thr Glu Thr Ile Ala Ser 
            340                 345                 350         


Leu Asn Leu Lys Pro Val Val Ala Val Tyr Ser Asp Glu Lys Val Gln 
        355                 360                 365             


Thr Val Ile Lys Leu Leu Lys Asp Asn Gly Phe Asp Gln Leu Pro Val 
    370                 375                 380                 


Leu Ala Lys Gly Thr Glu Lys Leu Ile Gly Leu Ile Thr Leu Ser Lys 
385                 390                 395                 400 


Leu Leu Lys Ser Val Ser Ser Gly Ser Val Ser Leu Asn Asp Asn Ile 
                405                 410                 415     


Glu Ser Ile Ile Leu Asp Phe Arg Lys Leu Asn Asn Phe Asp Asp Val 
            420                 425                 430         


Asn Leu Phe Asn Asp Asn Lys Ser Ser Lys Lys Lys Phe Gln Gln Ile 
        435                 440                 445             


Thr Thr Lys Thr Thr Leu Lys Glu Leu Asn Lys Phe Phe Glu Lys Asn 
    450                 455                 460                 


Ala Cys Ala Ile Val Thr Asp Glu Asn Leu Lys Pro Val His Val Val 
465                 470                 475                 480 


Thr Lys Val Asp Leu Leu Asp Tyr Phe Val Gly Gly Ile 
                485                 490             


<210>  13
<211>  438
<212>  PRT
<213>  Candida utilis

<400>  13

Met Thr Glu Tyr Ala Lys Arg His Thr Asp Ser Leu Leu Glu Asn Pro 
1               5                   10                  15      


Glu Ser Lys Arg Pro Glu Pro Asp Ala Thr Ala Thr Ser Glu Gly Val 
            20                  25                  30          


Leu Lys Lys Pro Asn Lys Pro Gly Arg Lys Pro Leu Asp Thr Glu Pro 
        35                  40                  45              


Lys Asn Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala Phe Arg 
    50                  55                  60                  


Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Glu Lys Ile Thr Thr 
65                  70                  75                  80  


Leu Glu Asp Glu Lys Arg Phe Ala Thr Thr Glu Ser Glu Phe Leu Arg 
                85                  90                  95      


Leu Gln Val Gln Met Leu Thr Gln Glu Leu Ala Lys His Arg Gly Thr 
            100                 105                 110         


Thr Asp Leu Ser Asp Leu Lys Leu Pro Leu Phe Thr Ser Pro Thr Glu 
        115                 120                 125             


Thr Asn Ser Thr Pro Asn Ser Glu Val Ser Thr Val Leu Thr Ser Val 
    130                 135                 140                 


Gly Ser Asp Asn Glu Leu Lys Arg Thr Gln Gln Glu Phe Ser Phe Glu 
145                 150                 155                 160 


Phe Pro Trp Ser Arg Lys Ser Ser Thr Thr Asn Ser Lys Arg Ser Pro 
                165                 170                 175     


Asn Ala Ser Asn Ala Ser Ser Asn Asn Val Pro Thr Leu Ala Ser Asp 
            180                 185                 190         


Ala Ser Thr Cys Ser Ser Gln Ser Ser Pro Phe Asp Leu Tyr Asn Ser 
        195                 200                 205             


Glu Glu Gln Asn Glu Leu Pro Leu Phe Asn Lys Val Val Lys Asp Ser 
    210                 215                 220                 


Thr Lys Met Pro Thr Glu Lys Phe Asn Phe Ser Glu His Phe Asp Glu 
225                 230                 235                 240 


Gly Val Asn Phe Cys Ser Asp Leu Gly Lys Ala Cys Gly Thr Arg Glu 
                245                 250                 255     


Cys Pro Ile Pro Glu Val Lys Ser Asn Thr Asn Thr Pro Leu Pro Val 
            260                 265                 270         


Glu Leu Asp His Asn Asp Pro Leu Asn Ser Leu Glu Asp Pro Ala Leu 
        275                 280                 285             


Asp Phe Asn Phe Gly Thr Phe Asp Pro Thr Val Ala Phe Ala Asn Glu 
    290                 295                 300                 


Ser Ser Tyr Ala Asp Leu Phe Asp Ser His Gly Glu Ser Asp Pro Leu 
305                 310                 315                 320 


Val Gly Leu Val Thr Glu Glu Ser Ala Tyr Asp Pro Phe Ser Met Phe 
                325                 330                 335     


Lys Asp Thr His Ala Arg Val Val Glu Arg Arg Glu Glu Ala Glu His 
            340                 345                 350         


Glu Glu Glu Glu Glu Pro Gln Gln Glu Gln Glu Gln Glu Gln Glu Gln 
        355                 360                 365             


Glu Gln Asp Pro Asp Val Val Pro Ser Asn Glu His Arg Leu Met Lys 
    370                 375                 380                 


Cys Thr Glu Ile Trp Asp Arg Ile Thr Ser His Pro Lys Tyr Ala Asp 
385                 390                 395                 400 


Ile Asp Ile Asp Gly Leu Cys Ser Glu Leu Arg Ser Lys Ala Lys Cys 
                405                 410                 415     


Ser Asp Lys Gly Val Val Ile Asp Tyr Lys Asp Val Asn Gln Val Ile 
            420                 425                 430         


Gln Arg Asn Ile Arg Lys 
        435             


<210>  14
<211>  497
<212>  PRT
<213>  Torulaspora delbrueckii

<400>  14

Met Thr Val Asp Thr Arg Thr Asn Val Ile Asp Leu Val Gly Asn Thr 
1               5                   10                  15      


Pro Met Val Glu Leu Thr Lys Leu Pro Ala Ala Leu Gly Val Lys Pro 
            20                  25                  30          


Arg Val Tyr Ala Lys Leu Glu Leu Tyr Asn Pro Gly Gly Ser Ile Lys 
        35                  40                  45              


Asp Arg Ile Ala Lys Ser Met Ile Glu Tyr Ala Glu Ala Ala Gly Glu 
    50                  55                  60                  


Ile His Pro Asp Arg Thr Thr Leu Ile Glu Pro Thr Ser Gly Asn Thr 
65                  70                  75                  80  


Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys Gly Tyr Arg Thr Ile 
                85                  90                  95      


Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys Val Ser Val Leu Lys 
            100                 105                 110         


Ala Leu Gly Ala Glu Ile Val Arg Thr Pro Thr Glu Ala Ala Trp Asp 
        115                 120                 125             


Ser Pro Glu Ser His Ile Gly Val Ala Glu Arg Leu Gln Lys Glu Ile 
    130                 135                 140                 


Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn Pro Arg Asn Pro Glu 
145                 150                 155                 160 


Ala His Tyr Leu Gly Thr Gly Lys Glu Ile Gln Asp Gln Leu Glu Lys 
                165                 170                 175     


Leu Gly Lys Phe Asp Ser Leu Lys Ala Val Ile Ala Gly Ala Gly Thr 
            180                 185                 190         


Gly Gly Thr Ile Ser Gly Ile Ser Lys Trp Leu Lys Gly Lys Asn Glu 
        195                 200                 205             


Asp Ile Lys Ile Val Gly Ala Asp Pro Val Gly Ser Ile Leu Ala Gln 
    210                 215                 220                 


Pro Gln Ser Leu Asn Glu Thr Ser Ala Pro Gly Tyr Lys Val Glu Gly 
225                 230                 235                 240 


Ile Gly Tyr Asp Phe Val Pro Asn Val Leu Asp Arg Ser Leu Val Asp 
                245                 250                 255     


Val Trp Tyr Lys Thr Glu Asp Lys Ala Ser Phe Lys Tyr Ala Arg Gln 
            260                 265                 270         


Leu Ile Ser Asn Glu Gly Val Leu Ile Gly Gly Ser Ser Gly Ser Ala 
        275                 280                 285             


Phe Thr Ala Leu Leu Lys Tyr Val Ala Glu His Pro Glu Leu Thr Glu 
    290                 295                 300                 


Asp Asp Val Leu Val Val Val Phe Pro Asp Ser Ile Arg Ser Tyr Leu 
305                 310                 315                 320 


Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys Asn Asp Leu Trp Asp 
                325                 330                 335     


Asp Glu Val Leu Ala Arg Val Lys Gln Thr Ser Thr Val Thr Lys Lys 
            340                 345                 350         


Asp Pro Phe Asn Gly Ala Lys Val Gln Asp Leu His Leu Lys Pro Val 
        355                 360                 365             


Val Ser Val Lys Glu Ser Ala Ser Leu Ala Glu Val Ile Lys Ile Leu 
    370                 375                 380                 


Lys Asp Asn Ala Phe Asp Gln Leu Pro Val Leu Thr Glu Asp Gly Lys 
385                 390                 395                 400 


Leu Ser Gly Leu Val Thr Leu Ser Leu Leu Leu Arg Lys Ile Ser Asn 
                405                 410                 415     


Gly Thr Ser Lys Asp Asp Ser Ile Lys Asp Ile Tyr Phe Asp Phe Lys 
            420                 425                 430         


Lys Leu Asn Asn Phe Asp Gln Val Ser Ser Tyr Asn Glu Asn Lys Ser 
        435                 440                 445             


Gly Lys Lys Lys Phe Thr Val Phe Thr Asn Gly Ser Lys Leu Ser Asp 
    450                 455                 460                 


Leu Asn Ser Phe Phe Glu Lys Asn Ser Ser Ala Ile Ile Thr Asp Gly 
465                 470                 475                 480 


Leu Arg Pro Val His Ile Val Thr Lys Ile Asp Leu Leu Asn Tyr Leu 
                485                 490                 495     


Ala 
    


<210>  15
<211>  466
<212>  PRT
<213>  Torulaspora delbrueckii

<400>  15

Met Glu Arg Ala Leu Pro Pro Leu Ile Ser Arg Thr Ser Thr Arg Ser 
1               5                   10                  15      


Asn Thr Ser Ser Met Ser Ala Met Ser Ala Ser Thr Val Lys Arg Pro 
            20                  25                  30          


Leu Glu Gln Ser Ser Ser Pro Met Ala Pro Ala Ala Lys Gly Ser Lys 
        35                  40                  45              


Pro Gly Arg Lys Pro Leu Asp Glu Glu Thr Lys Asn Lys Arg Thr Ala 
    50                  55                  60                  


Gln Asn Arg Ala Ala Gln Arg Ala Phe Arg Glu Arg Lys Glu Lys Lys 
65                  70                  75                  80  


Met Lys Glu Leu Glu Asp Lys Val Gln Ser Leu Glu Gln Ala Asn Arg 
                85                  90                  95      


Asp Thr Val Val Glu Ser Glu Phe Leu Arg Ser Gln Leu Leu Thr Leu 
            100                 105                 110         


Val Asn Glu Leu Lys Lys Tyr Arg Pro Ala Lys Ala Asn Asp Leu Gln 
        115                 120                 125             


Val Leu Asp Tyr Leu Ala Lys His Glu Arg Thr Glu Pro Thr Asp Lys 
    130                 135                 140                 


Glu Ile Glu Gln Ser Val Gln Lys Lys Met Asp Phe Thr Phe Ala Phe 
145                 150                 155                 160 


Pro Trp Lys Asp Arg Lys Glu Ala Glu Ala Gln Ala Gln His Phe Pro 
                165                 170                 175     


Ser Pro Gly Ser Ser Met Leu Ser Ser Ser Ser Ala Ser Val Asn Ser 
            180                 185                 190         


Ala Ala Ser Pro Ser Asn Lys Arg Arg Ser Thr Ala Ser Arg Ser Thr 
        195                 200                 205             


Ser Thr Ser Thr Ser Thr Thr Gly Trp Met Asp Asn Val Phe Tyr Ser 
    210                 215                 220                 


Asp Asp Ala Gln Lys Leu Pro Gln Phe Ala Ile Lys Gly Asp Ser Thr 
225                 230                 235                 240 


Ala Asp Pro Leu Phe Ser Asn Glu Phe Asn Phe Asp Asp Gln Phe Asp 
                245                 250                 255     


Glu Gln Val Ser Gln Phe Cys Thr Lys Met Asn Lys Ala Cys Gly Thr 
            260                 265                 270         


Arg Glu Cys Pro Ile Pro Gly Phe Thr Pro Gln Met Ala Ser Pro Gln 
        275                 280                 285             


Val Ala Ser Pro Gln Ile Leu Thr Asn Ser Trp Asp Thr Val Ala Ser 
    290                 295                 300                 


Pro Ala Phe Gly Gln Gln Ser Leu Ala Pro Ser Lys Lys Gln Leu Thr 
305                 310                 315                 320 


Lys Thr Pro Pro Ser Gln Pro Glu Leu Pro Phe Ile Asp Pro Thr Met 
                325                 330                 335     


Ala Phe Pro Thr Asp Asp Asp Glu Gly Leu Phe Phe Arg Thr His Arg 
            340                 345                 350         


Asp Glu Asn Ser Leu Phe Ala Glu Leu Leu Asp Glu Val Glu Pro Thr 
        355                 360                 365             


Asp Asn Asn Phe Val Asn Glu Asn Leu Ile Asn Glu Glu Pro Ser Thr 
    370                 375                 380                 


Thr Thr Ala Val Ala Glu Glu Thr Arg Pro Lys Pro Lys Thr Glu Thr 
385                 390                 395                 400 


Asp Val Val Pro Ser Arg Asp Gly Lys Leu Leu Lys Cys Ser Glu Val 
                405                 410                 415     


Trp Asp Arg Ile Thr Thr His Pro Lys Tyr Ser Ala Ile Asp Ile Asp 
            420                 425                 430         


Gly Leu Cys Gly Glu Leu Met Thr Lys Ala Lys Cys Ser Glu Lys Gly 
        435                 440                 445             


Val Val Val Gln Ala Glu Asp Val Gln Arg Val Leu Asp Lys His Met 
    450                 455                 460                 


Asp Val 
465     


<210>  16
<211>  500
<212>  PRT
<213>  Zygosaccharomyces bailii

<400>  16

Met Val Val Asp Thr Arg Thr Asn Val Ile Asp Leu Val Gly Asn Thr 
1               5                   10                  15      


Pro Leu Ile Glu Leu Lys Thr Leu Pro Lys Ala Leu Gly Ile Lys Pro 
            20                  25                  30          


Lys Val Tyr Ala Lys Leu Glu Leu Tyr Asn Pro Gly Gly Ser Ile Lys 
        35                  40                  45              


Asp Arg Ile Ala Lys Thr Met Ile Glu Tyr Ala Glu Lys Asn Gly Glu 
    50                  55                  60                  


Ile His Pro Asp Arg Thr Thr Leu Ile Glu Pro Thr Ser Gly Asn Thr 
65                  70                  75                  80  


Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys Gly Tyr Arg Thr Ile 
                85                  90                  95      


Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys Val Ser Val Leu Lys 
            100                 105                 110         


Ala Leu Gly Ala Glu Ile Val Arg Thr Pro Thr Ser Ala Ala Trp Asp 
        115                 120                 125             


Ser Pro Glu Ser His Ile Gly Val Ala Lys Arg Leu Glu Lys Glu Ile 
    130                 135                 140                 


Pro Gly Ala Val Ile Leu Asp Gln Tyr Asn Asn Pro Arg Asn Pro Glu 
145                 150                 155                 160 


Ala His Tyr Tyr Gly Thr Gly Lys Glu Ile Gln Glu Gln Leu Gln Asn 
                165                 170                 175     


Leu Asn Glu Phe Asp Asn Leu Lys Ala Val Ile Ala Gly Ala Gly Thr 
            180                 185                 190         


Gly Gly Thr Ile Thr Gly Ile Ser Lys Tyr Leu Lys Glu Gln Asn Asp 
        195                 200                 205             


Asn Ile Thr Ile Val Gly Ala Asp Pro Phe Gly Ser Ile Leu Ala Gln 
    210                 215                 220                 


Pro Glu Ser Leu Asn Lys Thr Asp Val Gly Glu Tyr Lys Val Glu Gly 
225                 230                 235                 240 


Ile Gly Tyr Asp Phe Val Pro Lys Val Leu Asn Arg Asn Glu Ile Asp 
                245                 250                 255     


Thr Trp Tyr Lys Thr Asp Asp Lys Asp Ser Phe Val Tyr Ala Arg Gln 
            260                 265                 270         


Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly Ser Ser Gly Ser Ala 
        275                 280                 285             


Phe Ser Ala Leu Val Lys Tyr Ala Lys Asp His Pro Glu Leu Asp Glu 
    290                 295                 300                 


Asn Asp Val Leu Val Ala Ile Phe Pro Asp Ser Ile Arg Ser Tyr Leu 
305                 310                 315                 320 


Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Lys Asn Asn Leu Trp Ser 
                325                 330                 335     


Asp Asp Val Leu Ala Arg Val Gly Thr Lys Gly Pro Ser Asn Ile Asp 
            340                 345                 350         


Arg Lys Asp Pro Phe His Gly Ala Thr Val Gln Asp Leu Lys Leu Lys 
        355                 360                 365             


Pro Val Val Ser Val Lys Glu Asn Ala Ala Val Ala Asp Ala Ile Gln 
    370                 375                 380                 


Ile Leu Arg Gln Asn Ala Phe Asp Gln Leu Pro Val Leu Ala Glu Asp 
385                 390                 395                 400 


Gly Lys Leu Ser Gly Leu Val Thr Leu Ser Gln Leu Leu Lys Lys Leu 
                405                 410                 415     


Ser Asn Gly Thr Ala Thr Lys Glu Asp Lys Ile Lys Ser Phe Tyr Ile 
            420                 425                 430         


Asp Phe Arg Lys Leu Asn Asn Phe Asp Asp Val Ser Ser Tyr Asn Glu 
        435                 440                 445             


Asn Lys Ser Gly Lys Lys Lys Phe Val Gln Phe Thr Asn Ser Ser Lys 
    450                 455                 460                 


Leu Ser Asp Leu Asn Asn Phe Phe Glu Lys Asn Ser Ser Ala Ile Ile 
465                 470                 475                 480 


Thr Glu Gly Ser Lys Pro Val His Ile Val Thr Lys Ile Asp Leu Leu 
                485                 490                 495     


Asp Tyr Leu Ile 
            500 


<210>  17
<211>  547
<212>  PRT
<213>  Zygosaccharomyces bailii

<400>  17

Met Ser Ala Thr Ser Ala Lys Arg Pro Leu Glu Pro Thr Val Ser Leu 
1               5                   10                  15      


Glu Phe Ala Asn Asp Glu Ala Glu Lys Ser Pro Thr Ser Glu Glu Pro 
            20                  25                  30          


Arg Lys Lys Gly Gly Lys Pro Gly Arg Lys Pro Leu Asp Ser Glu Ala 
        35                  40                  45              


Lys Asn Lys Arg Thr Ala Gln Asn Arg Ala Ala Gln Arg Ala Phe Arg 
    50                  55                  60                  


Glu Arg Lys Glu Arg Lys Met Lys Glu Leu Glu Glu Lys Val His Ala 
65                  70                  75                  80  


Leu Glu Glu Met Asn Gln Gln Ser Leu Val Glu Thr Glu Phe Leu Arg 
                85                  90                  95      


Ser Gln Leu Val Thr Leu Val Asn Glu Leu Lys Lys Tyr Arg Pro Gln 
            100                 105                 110         


Asn Gln Ala Asp Ser Gln Val Leu Glu Tyr Leu Ala Lys Thr Glu Asn 
        115                 120                 125             


Asp Asn Asp Ala Ala Gly Gln Gln Thr Arg Gln Glu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Leu Gln Glu Ser Val Arg Arg Lys Met Ser Phe Thr Phe Ala Phe 
145                 150                 155                 160 


Pro Trp Lys Asn Glu Ile Lys Ser Glu Glu Lys Ala Gly Ser Pro Ala 
                165                 170                 175     


Ala Thr Glu Gln Pro Arg Asn Asp Asn Leu Gln Phe Pro Ser Pro Gly 
            180                 185                 190         


Ser Ser Ser Lys Ser Ser Ser Val Ser Thr Ser Ser Ser Leu Ser Lys 
        195                 200                 205             


Lys Lys Ile Gly Leu Tyr Thr Pro Gly Thr Thr Asp Ser Asn Ala Asn 
    210                 215                 220                 


Asn Asn Asn Leu Ser Ser Ser Thr Ser Asn Leu Asn Asn Gly Ser Phe 
225                 230                 235                 240 


Thr Pro Gly Ser Ser Ser Thr Gly Trp Met Asp Asn Val Phe Tyr Asn 
                245                 250                 255     


Asp Asp Ala Gln Gln Leu Pro Gln Phe Tyr Gln Ser Ala Thr Asp Asn 
            260                 265                 270         


Ser Gly Thr Thr Asn Asn Lys Leu Leu Glu Asp Asn Thr Ser Val Pro 
        275                 280                 285             


Tyr Gly Tyr Asp Ser Val Thr Phe Ser Asn Gln Phe Asn Phe Asp Asp 
    290                 295                 300                 


Gln Phe Asp Glu Gln Val Ser Glu Phe Cys Ala Lys Leu Gly Gln Val 
305                 310                 315                 320 


Cys Gly Thr Lys Asp Cys Pro Val Pro Lys Gln Lys Thr Ala Ser Ser 
                325                 330                 335     


Thr Pro Asn Ile Thr Asn Ser Pro Leu Val Leu Ser Asn Thr Trp Gly 
            340                 345                 350         


Ser Pro Ser Lys His Gln Gly Glu Lys Ile Val Thr Thr Val Ser Ala 
        355                 360                 365             


Pro Ala Pro Ser Asp Lys Thr Ala Ala Ala Glu Gly Lys Asp Ala Gly 
    370                 375                 380                 


Thr Thr Lys Ser Gly Glu Leu Pro Phe Ile Asp Thr Ser Leu Ala Phe 
385                 390                 395                 400 


Pro Glu Glu Gln Asp Leu Phe Arg Asp Ser Gln Pro Asp Asn Leu Phe 
                405                 410                 415     


Ala Glu Phe Ile Glu Asp Glu Pro Glu Arg Asp Asp Asp Pro Phe Leu 
            420                 425                 430         


Ala Ala Asn Leu Ile Asn Glu Glu Pro Gln Gly Pro Gln Gln Gln Asn 
        435                 440                 445             


Ile Gln Pro Gln Lys His Glu Gln Asp Gln Ile Gln Thr Gln Gln Gln 
    450                 455                 460                 


Arg Gln Gln Gln Asp Ala Lys Gln His Gln Ala Thr Asp Val Ala Asp 
465                 470                 475                 480 


Cys Asp Gly Val Val Pro Ser Arg Asp Gly Lys Leu Leu Lys Cys Ser 
                485                 490                 495     


Glu Val Trp Asp Arg Ile Thr Ser His Pro Lys Tyr Thr Asp Met Asp 
            500                 505                 510         


Ile Asp Gly Leu Cys Leu Glu Leu Met Ala Lys Ala Lys Cys Ser Glu 
        515                 520                 525             


Lys Gly Val Val Val Gln Ala Glu Asp Val Gln Arg Ala Leu Ala Asn 
    530                 535                 540                 


Arg Leu Asp 
545         


<210>  18
<211>  552
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  18

Met Ser Gly Gln Thr Glu Thr Leu Ser Ser Thr Ser Asn Ile Pro Ile 
1               5                   10                  15      


Ala Lys Ala Glu Pro Glu Gln Ser Ala Asp Phe Ser Ala Ser His Lys 
            20                  25                  30          


Lys Arg Gly Pro Val Ser Asp Arg Ser Ser Arg Arg Thr Ser Ser Glu 
        35                  40                  45              


Glu Val Asp Leu Met Pro Asn Val Asp Asp Glu Val Asp Gly Asp Val 
    50                  55                  60                  


Lys Pro Lys Lys Ile Gly Arg Lys Asn Ser Asp Gln Glu Pro Ser Ser 
65                  70                  75                  80  


Lys Arg Lys Ala Gln Asn Arg Ala Ala Gln Arg Ala Phe Arg Lys Arg 
                85                  90                  95      


Lys Glu Asp His Leu Lys Ala Leu Glu Thr Gln Val Val Thr Leu Lys 
            100                 105                 110         


Glu Leu His Ser Ser Thr Thr Leu Glu Asn Asp Gln Leu Arg Gln Lys 
        115                 120                 125             


Val Arg Gln Leu Glu Glu Glu Leu Arg Ile Leu Lys Asp Gly Ser Phe 
    130                 135                 140                 


Thr Phe Glu Met Ser Leu Pro His Arg Asn Pro Ser Leu Ser Ser Leu 
145                 150                 155                 160 


Pro Thr Thr Gly Phe Ser Ser Asn Phe Ala His Met Lys Asp Gly Ile 
                165                 170                 175     


Ser Pro Gln Ser Asn Leu His Leu Ser Pro Asn Ser Ile Glu Lys Pro 
            180                 185                 190         


Asn Met His Gln Asn Val Leu His Asn Asp Arg Ser Ala Asp Asn Leu 
        195                 200                 205             


Asn His Arg Tyr Gln Val Pro Pro Thr Leu Val Asp Ser Asn Ser Ala 
    210                 215                 220                 


Gln Gly Thr Leu Ser Pro Glu Thr Pro Ser Ser Ser Asp Ser Pro Ser 
225                 230                 235                 240 


Asn Leu Tyr Leu Asn Tyr Pro Lys Arg Lys Ser Ile Thr His Leu His 
                245                 250                 255     


His Asp Cys Ser Ala Leu Ser Asn Gly Glu Asn Gly Glu Asp Val Ala 
            260                 265                 270         


Asp Gly Lys Gln Phe Cys Gln Lys Leu Ser Thr Ala Cys Gly Ser Ile 
        275                 280                 285             


Ala Cys Ser Met Leu Thr Lys Thr Thr Pro His Arg Ala Ser Val Asp 
    290                 295                 300                 


Ile Leu Ser Asn Leu His Glu Ser Thr Val Ser Pro Pro Met Ala Asp 
305                 310                 315                 320 


Glu Ser Val Gln Arg Ser Ser Glu Val Ser Lys Ser Ile Pro Asn Val 
                325                 330                 335     


Glu Leu Ser Leu Asn Val Asn Gln Gln Phe Val Ser Pro Phe Gly Gly 
            340                 345                 350         


Thr Asp Ser Phe Pro Leu Pro Thr Asp Thr Gly Leu Asp Ser Leu Phe 
        355                 360                 365             


Glu Pro Asp Ser Ala Ile Glu Asn Ser His Leu Lys Asn Val Val Met 
    370                 375                 380                 


Glu Pro Glu Leu Phe Gln Ala Trp Arg Glu Pro Ala Glu Ser Leu Asp 
385                 390                 395                 400 


Lys Glu Phe Phe Asn Asp Glu Gly Glu Ile Asp Asp Val Phe His Asn 
                405                 410                 415     


Tyr Phe His Asn Ser Asn Glu Asn Gly Asp Leu Ile Thr Asn Ser Leu 
            420                 425                 430         


His Gly Leu Asp Phe Leu Glu Asn Ala Asn Glu Ser Phe Pro Glu Gln 
        435                 440                 445             


Met Tyr Pro Phe Ile Lys His Asn Lys Asp Tyr Ile Ser Asn His Pro 
    450                 455                 460                 


Asp Glu Val Pro Pro Asp Gly Leu Pro Gln Lys Gly Lys His Asp Thr 
465                 470                 475                 480 


Ser Ser Gln Met Pro Ser Glu Asn Glu Ile Val Pro Ala Lys Glu Arg 
                485                 490                 495     


Ala Tyr Leu Ser Cys Pro Lys Val Trp Ser Lys Ile Ile Asn His Pro 
            500                 505                 510         


Arg Phe Glu Ser Phe Asp Ile Asp Asp Leu Cys Ser Lys Leu Lys Asn 
        515                 520                 525             


Lys Ala Lys Cys Ser Ser Ser Gly Val Leu Leu Asp Glu Arg Asp Val 
    530                 535                 540                 


Glu Ala Ala Leu Asn Gln Phe Asn 
545                 550         


<210>  19
<211>  494
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  19

Met Ser Ser Val Pro Pro Leu Tyr Glu Asn Ala Leu Asp Leu Ile Gly 
1               5                   10                  15      


Asn Thr Pro Leu Ile Lys Leu Asn Lys Ile Pro Gln Ser Tyr Gly Ile 
            20                  25                  30          


Lys Ala Lys Val Tyr Ala Lys Val Glu Leu Phe Asn Ala Gly Gly Ser 
        35                  40                  45              


Ile Lys Asp Arg Ile Ser Lys Asn Met Ile Leu Glu Ala Glu Lys Ser 
    50                  55                  60                  


Gly Arg Ile Lys Pro Gly Tyr Thr Leu Ile Glu Pro Thr Ser Gly Asn 
65                  70                  75                  80  


Thr Gly Ile Gly Leu Ala Leu Val Ala Ala Val Lys Gly Tyr Arg Thr 
                85                  90                  95      


Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys Val Ser Val Leu 
            100                 105                 110         


Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr Glu Ala Ala Trp 
        115                 120                 125             


Asp Ala Pro Glu Ser His Ile Gly Val Ala Lys Lys Leu Glu Lys Glu 
    130                 135                 140                 


Ile Pro Asn Ser Val Ile Leu Asp Gln Tyr Ser Asn Pro Ala Asn Pro 
145                 150                 155                 160 


Asp Ala His Tyr Tyr Gly Thr Gly Phe Glu Ile Trp Glu Gln Thr Lys 
                165                 170                 175     


Gly Lys Val Thr His Leu Val Ala Gly Ala Gly Thr Gly Gly Thr Ile 
            180                 185                 190         


Thr Gly Ile Ser Arg Tyr Leu Lys Glu Lys Asn Pro Lys Val Glu Val 
        195                 200                 205             


Thr Gly Ala Asp Pro Lys Gly Ser Ile Leu Ala Gln Pro Glu Ser Leu 
    210                 215                 220                 


Asn Thr Ser Thr Glu Gly Tyr Leu Val Glu Gly Ile Gly Tyr Asp Phe 
225                 230                 235                 240 


Ile Pro Asp Val Leu Asn Arg Lys Tyr Val Asp Asn Trp Ile Lys Thr 
                245                 250                 255     


Glu Asp Ala Glu Ser Phe Lys Leu Ala Arg Arg Ile Ile Arg Glu Glu 
            260                 265                 270         


Gly Ile Leu Val Gly Gly Ser Ser Gly Ser Ala Leu Gln Ala Ala Leu 
        275                 280                 285             


Gln Val Ala Lys Asp Leu Thr Glu Asp Asp Val Val Val Val Val Phe 
    290                 295                 300                 


Pro Asp Ser Ile Arg Ser Tyr Leu Ser Lys Phe Ala Asp Asp Glu Trp 
305                 310                 315                 320 


Met Lys Ile Asn Asn Phe Ala Val Asp Glu Thr Ser Ser Ser Gly Asn 
                325                 330                 335     


Lys Ser Asp Asp Phe Leu Ala Ser Lys Thr Ile Arg Asp Leu Val Ala 
            340                 345                 350         


Gly Lys Ala Pro Val Val Thr Val Thr Leu Ser Asp Thr Val Gly Lys 
        355                 360                 365             


Thr Phe Asp Leu Leu His Asp Asn Gly Phe Asp Gln Leu Pro Val Leu 
    370                 375                 380                 


Asn Asn Ser Gly Lys Leu Val Gly Leu Val Thr Leu Ser Lys Ile Leu 
385                 390                 395                 400 


Lys Ser Leu Ser Thr Lys Lys Val Gln Leu Thr Asn Ser Ile Ala Ser 
                405                 410                 415     


Val Ile Ile Asp Phe Arg Lys Leu Ala Asp Phe Glu Lys Ser Phe Thr 
            420                 425                 430         


Ile Ala Lys Glu Ser Gly Phe Thr Lys Arg Ser Tyr Glu Pro Ile Thr 
        435                 440                 445             


Leu Asp Thr Pro Leu Ala Leu Leu Asn Lys Phe Phe Glu Thr Asn Ser 
    450                 455                 460                 


Asn Ala Ile Ile Thr Asp Asp Glu Leu Lys Pro Val Gln Ile Val Thr 
465                 470                 475                 480 


Lys Val Asp Leu Ile Ser Phe Leu Thr Lys Asn Val Ala Phe 
                485                 490                 


<210>  20
<211>  493
<212>  PRT
<213>  Kluyveromyces lactis

<400>  20

Met Gly Tyr Asp Thr Arg His Asp Val Ile Asp Leu Val Gly Asn Thr 
1               5                   10                  15      


Pro Leu Ile Arg Leu Gln Lys Leu Pro Lys Ala Ile Gly Ile Lys Pro 
            20                  25                  30          


Lys Val Tyr Ala Lys Leu Glu Leu Tyr Asn Pro Gly Gly Ser Ile Lys 
        35                  40                  45              


Asp Arg Ile Ala Lys Ser Met Ile Glu Ala Ala Glu Glu Glu Gly Ile 
    50                  55                  60                  


Ile His Pro Ser Arg Ser Thr Leu Ile Glu Pro Thr Ser Gly Asn Thr 
65                  70                  75                  80  


Gly Ile Gly Leu Ala Leu Ile Gly Ala Ile Lys Gly Tyr Arg Thr Ile 
                85                  90                  95      


Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys Val Ser Val Leu Lys 
            100                 105                 110         


Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr Ala Ala Ala Trp Asp 
        115                 120                 125             


Ser Pro Glu Ser His Ile Gly Val Ala Leu Arg Leu Glu Lys Glu Ile 
    130                 135                 140                 


Pro Gly Gly Ile Ile Leu Asp Gln Tyr Asn Asn Met Lys Asn Pro Glu 
145                 150                 155                 160 


Ala His Tyr Phe Gly Thr Gly Lys Glu Ile His His Gln Leu Glu Asp 
                165                 170                 175     


Leu Ser Leu Phe Ser Lys Leu Lys Ala Val Val Ala Gly Ala Gly Thr 
            180                 185                 190         


Gly Gly Thr Ile Ser Gly Ile Ser Lys Tyr Ile Lys Glu Gln Asn Asp 
        195                 200                 205             


Lys Ile Ala Ile Val Gly Ala Asp Pro Val Gly Ser Ile Leu Ala Val 
    210                 215                 220                 


Pro Glu Lys Leu Asn Glu Thr Asp Val Thr Glu Tyr Lys Val Glu Gly 
225                 230                 235                 240 


Ile Gly Tyr Asp Phe Val Pro Lys Val Leu Asn Arg Asp Ser Val Asp 
                245                 250                 255     


His Trp Val Lys Thr Asp Asp Lys Ser Ser Phe Lys Tyr Ala Arg Gln 
            260                 265                 270         


Leu Ile Ser Asn Glu Gly Val Leu Val Gly Gly Ser Ser Gly Ser Ala 
        275                 280                 285             


Phe Thr Ala Leu Val Asp Tyr Cys Asn Glu His Pro Glu Leu Thr Glu 
    290                 295                 300                 


Asp Asp Val Ile Val Val Ile Phe Pro Asp Ser Val Arg Ser Tyr Leu 
305                 310                 315                 320 


Thr Lys Phe Val Asp Asp Glu Trp Leu Lys Thr Asn Gly Leu Trp Asp 
                325                 330                 335     


Asp Ala Ile Ala Thr Pro Ile Val Gln Lys Glu Thr Asp Val Phe Glu 
            340                 345                 350         


Asp Ala Thr Val Lys Asp Leu Asn Leu Lys Pro Val Val Ser Val Glu 
        355                 360                 365             


Glu Asp Ala Ser Val Ala Thr Val Ile Lys Ile Leu Arg Asp Asn Ser 
    370                 375                 380                 


Phe Asp Gln Leu Pro Val Leu Thr Lys Asp Gly Lys Leu Cys Gly Leu 
385                 390                 395                 400 


Val Thr Leu Ser Gln Leu Leu Lys Lys Leu Ser Thr Ser Lys Asp Val 
                405                 410                 415     


Ser Ser Ile Lys Ser Leu Phe Phe Asp Phe Arg Lys Leu Asn Asn Phe 
            420                 425                 430         


Asp Asp Ile Ser Ser Tyr Asn Ala Asp Lys Ser His Lys Lys Ile Phe 
        435                 440                 445             


Val Arg Phe Asp Val Asn Thr Thr Leu Ser Glu Leu Asn Ser Phe Phe 
    450                 455                 460                 


Glu Lys Asn Ser Ala Ala Ile Ile Thr Glu Gly Leu Asn Pro Val His 
465                 470                 475                 480 


Ile Val Thr Lys Val Asp Leu Leu Ser Tyr Leu Ala Lys 
                485                 490             


<210>  21
<211>  583
<212>  PRT
<213>  Kluyveromyces lactis

<400>  21

Met Ser Thr Ser Thr Ala Lys Arg Pro Phe Asp Asn Lys Arg Ala Gly 
1               5                   10                  15      


Ser Pro Asp Asp Gly Thr Asp Ser Asp Ser Gly Gly Asn Asn Ser Gly 
            20                  25                  30          


Ser Ser Pro Ala Ser Lys Arg Arg Glu Arg Lys Pro Gly Arg Lys Pro 
        35                  40                  45              


Leu Glu Thr Glu Ala Lys Asp Lys Arg Thr Ala Gln Asn Arg Ala Ala 
    50                  55                  60                  


Gln Arg Ala Phe Arg Glu Arg Arg Glu Arg Lys Met Lys Glu Leu Glu 
65                  70                  75                  80  


Asp Lys Val Ser Gln Leu Glu Ser Leu Asn Lys Gln Ser Glu Leu Glu 
                85                  90                  95      


Thr Lys Phe Leu Arg Asn Gln Val Thr Asn Leu Leu Ser Glu Leu Lys 
            100                 105                 110         


Arg Tyr Asn Pro Glu Leu Pro Lys Lys Arg Asp Ser Ile Leu Leu Asp 
        115                 120                 125             


Tyr Leu Ala Lys Gln Arg Lys Ala Ser Ile Asp Ser Asn Pro Asp Phe 
    130                 135                 140                 


Ser Ala Ala Ala Asn Lys Ala Ala Asn Ser Lys Asp Ser Ser Thr Ala 
145                 150                 155                 160 


Ile Ser Ser Ser Asn Phe Gln Phe Glu Phe Pro Trp Lys Met Asp Pro 
                165                 170                 175     


Ser Lys Ile Pro Ser Pro Ser Ser Asp Ser Thr Ser Pro Ser Ala Ser 
            180                 185                 190         


Thr Ser Ile Leu Asp Asn Ala Asn Asn Lys Ser Val Ser Ser Thr Asn 
        195                 200                 205             


Leu Asn His Ser Arg Ser Ser Ile Ser Asn Ser Ser Ser Ser Pro Ser 
    210                 215                 220                 


Asn Val Asn Gly Leu Ser Ser Arg Lys His Ser Asn Thr Leu Asn Leu 
225                 230                 235                 240 


Tyr Gln Thr Gln Ser Asn Val Thr Ser Glu Phe Asp Phe Asp Ser Gln 
                245                 250                 255     


Phe Asp Glu Ser Val Ser Ser Phe Cys Ser Lys Leu Ser Met Ala Cys 
            260                 265                 270         


Gly Thr Lys Ser Asn Pro Ile Pro Lys Ala Ser Pro Val Ser Thr Pro 
        275                 280                 285             


Ser Ser Ser Asp Leu Leu Lys Pro Lys Ser Asn Ser Asn Val Asn Ile 
    290                 295                 300                 


Thr Asn His Asn Asn Asn Lys Ile Asn Ser Lys Asp Leu Ser Ser Ser 
305                 310                 315                 320 


Ala Pro Leu His Asp Ser Ala Ser Ala Ser Ala Leu Asn Asn His Asp 
                325                 330                 335     


Ser Val Asn Ala Val Ser Asn Gln Phe Ser Val Asp Lys Gln Tyr Asn 
            340                 345                 350         


Asp Ser Ser His Ser Gln Ala Thr Pro Asn Gly Leu Asp Asn Asp Ser 
        355                 360                 365             


Ser Val Ser Ala Trp Gln Gln Pro Ser Phe Gly Gln Leu Gly Phe Arg 
    370                 375                 380                 


Thr Asp Gln Leu Phe Asp Leu Asp Leu Asp Ser Ala Ser Pro Ile Thr 
385                 390                 395                 400 


Lys Gln Lys Asp Asn Asn Tyr Ser Thr Thr Thr Asn Asn Thr Asn Ser 
                405                 410                 415     


Pro Ala Lys Ala Asp Gly Met Tyr Trp Asn Phe Asn Thr Pro Leu Ser 
            420                 425                 430         


Asn Met Val Ser Arg Asn Met Gln Asn Pro Glu Ile Pro Phe Ile Asp 
        435                 440                 445             


Thr Gly Leu Ala Phe Pro Asp Tyr Asp Asp Pro Leu Leu Asp Ile Leu 
    450                 455                 460                 


Lys Glu Glu Gln Glu Asn Glu Gln Val Glu Gly Asp Ser Asp Pro Ile 
465                 470                 475                 480 


Gln Ala Leu Ile Asn Glu Glu Pro Ser Met Pro Leu Cys His Asp Pro 
                485                 490                 495     


Ala Ala Asn Ala Gly Ala Ser Val Ser Glu Thr Asp Lys Leu Ser Asn 
            500                 505                 510         


Gln Glu Glu Ile Val Gln Asp Ile Ile Pro Ser Asn Asp Gly Lys Leu 
        515                 520                 525             


Leu Lys Cys Ser Glu Val Trp Asp Arg Ile Thr Ala His Pro Arg Tyr 
    530                 535                 540                 


Ser Asp Leu Asp Ile Asp Gly Leu Cys Leu Glu Leu Arg Thr Lys Ala 
545                 550                 555                 560 


Lys Cys Ser Glu Lys Gly Val Val Val Asn Ala Glu Asp Val Gln Lys 
                565                 570                 575     


Ala Leu Ile Ser His Met Gln 
            580             


<210>  22
<211>  501
<212>  PRT
<213>  Pichia pastoris

<400>  22

Met Ser Asp Asn Asn Gln Pro Leu Pro Pro Val Ser Asn Ser Ile Leu 
1               5                   10                  15      


Glu His Ile Gly Lys Thr Pro Leu Val Lys Leu Asn Arg Ile Pro Lys 
            20                  25                  30          


Ile Leu Asn Leu Lys Pro Gln Val Tyr Ala Lys Val Glu Leu Phe Asn 
        35                  40                  45              


Ser Gly Gly Ser Ile Lys Asp Arg Ile Ala Leu Arg Met Val Glu Gln 
    50                  55                  60                  


Ala Glu Lys Glu Gly Arg Ile Lys Pro Gly Tyr Thr Leu Ile Glu Pro 
65                  70                  75                  80  


Thr Ser Gly Asn Thr Gly Ile Gly Leu Ala Leu Val Gly Ala Val Lys 
                85                  90                  95      


Gly Tyr Arg Thr Ile Ile Thr Leu Pro Glu Lys Met Ser Asn Glu Lys 
            100                 105                 110         


Val Ala Val Leu Lys Ala Leu Gly Ala Glu Ile Ile Arg Thr Pro Thr 
        115                 120                 125             


Glu Ala Ala Trp Asp Ser Pro Glu Ser His Ile Gly Val Ala Arg Arg 
    130                 135                 140                 


Leu Glu Lys Glu Ile Pro Asn Ala Val Ile Leu Asp Gln Tyr Gly Asn 
145                 150                 155                 160 


Val Asn Asn Pro Asp Ala His Phe Tyr Thr Thr Gly Ala Glu Ile Trp 
                165                 170                 175     


Asp Gln Thr Asn Gly Lys Val Thr His Val Val Ala Gly Ala Gly Thr 
            180                 185                 190         


Gly Gly Thr Ile Thr Gly Ile Ala Lys Phe Leu Lys Ser Lys Asn Pro 
        195                 200                 205             


Asn Ile Gln Ile Ile Gly Ala Asp Pro His Gly Ser Ile Leu Ala Leu 
    210                 215                 220                 


Pro Glu Ser Leu Asn Thr Ser Asn Glu Gln Tyr Lys Val Glu Gly Ile 
225                 230                 235                 240 


Gly Tyr Asp Phe Ile Pro Glu Val Leu Asp Arg Glu Ile Val Asp Thr 
                245                 250                 255     


Trp Tyr Lys Thr Asp Asp Lys Asp Ser Phe Lys Leu Ala Arg Gln Leu 
            260                 265                 270         


Ile Ser Glu Glu Gly Ile Leu Val Gly Gly Ser Ser Gly Ser Ala Leu 
        275                 280                 285             


Ser Ala Ala Val Lys Ile Ile Asn Asp Ala Lys Leu Asp Glu Ser Ala 
    290                 295                 300                 


Val Val Val Val Val Cys Pro Asp Ser Ile Arg Ser Tyr Leu Thr Lys 
305                 310                 315                 320 


Phe Ala Asp Asp Asp Trp Met Lys Leu Asn Gly Phe Thr Glu Asp Glu 
                325                 330                 335     


Pro Ala Pro Leu Lys Arg Lys Ser Ser Phe Ser Lys Asp Thr Leu Ser 
            340                 345                 350         


Ser Tyr Thr Ile Lys Asp Leu Ala Leu Lys Pro Val Val Ser Val Thr 
        355                 360                 365             


Ile Asp Asp Ser Ile Glu Ser Thr Ile Asn Ile Leu Gln Thr Lys Gly 
    370                 375                 380                 


Phe Asp Gln Leu Pro Val Leu Lys Asn Asp Lys Leu Ala Gly Ile Val 
385                 390                 395                 400 


Thr Leu Ser Gln Leu Leu Arg Leu Leu Ser Asn Lys Lys Ile His Leu 
                405                 410                 415     


Thr Ser Lys Val Glu Ser Ala Tyr Phe Asp Phe Ser Lys Leu Glu Asn 
            420                 425                 430         


Phe Glu Lys Ser Tyr Asn Ile Asn Lys Glu Ser Thr Asn Lys Arg Arg 
        435                 440                 445             


Glu Tyr Gln Lys Ile Thr Thr Ser Thr Thr Leu Ala Lys Leu Asn Lys 
    450                 455                 460                 


Phe Phe Glu Thr Ser Ser Ala Ala Ile Val Glu Asn Asp Lys Gly Gln 
465                 470                 475                 480 


Pro Ile His Ile Val Ser Lys Val Asp Leu Leu Ser Phe Leu Ala Ser 
                485                 490                 495     


Lys Gly Glu Phe Asn 
            500     


<210>  23
<211>  461
<212>  PRT
<213>  Pichia pastoris

<400>  23

Met Ser Asp Val Val Asn Lys Arg Ala Ala Thr Ser Ser Thr Gln Thr 
1               5                   10                  15      


Asn Lys Arg Gln Glu Leu Ser Ser Ala Leu Thr Lys Pro Gly Arg Lys 
            20                  25                  30          


Pro Val Gln Thr Glu Pro Lys Asp Lys Arg Thr Ala Gln Asn Arg Ala 
        35                  40                  45              


Ala Gln Arg Ala Phe Arg Glu Arg Lys Glu Lys Lys Met Lys Glu Leu 
    50                  55                  60                  


Glu Thr Lys Val Glu Glu Leu Glu Arg Gln Lys Ser Gln Leu Asn Thr 
65                  70                  75                  80  


Glu Ser Glu Phe Leu Arg Ser Gln Val Glu Thr Leu Ile His Glu Leu 
                85                  90                  95      


Ser Lys Tyr Arg Gly Glu Thr Asp Val Leu Ser Leu Leu Pro Thr Ser 
            100                 105                 110         


Ile Pro Gln Glu Ser Lys Lys Met Val Arg Thr Pro Ser Ser Asn Thr 
        115                 120                 125             


Thr Asn Ser Ser Ser Val Gly Val Thr Pro Ser Ser Ser Thr Leu Arg 
    130                 135                 140                 


Ser Ser Ser Ser Ser Gly Val Tyr Glu Phe Pro Trp Lys Leu Ser Asn 
145                 150                 155                 160 


Ser Gln Asn Pro Ser Gly Ser Asn Ser Pro Leu Asp Leu Thr Lys Ala 
                165                 170                 175     


Gly Gln Leu Pro Ser Pro Thr Ser Ile Asn Gln Asn Pro Gly Leu Thr 
            180                 185                 190         


Ala Glu Ser Val Lys Ser Ser Ser Val Ser Ser Glu Ser Pro Asn Ser 
        195                 200                 205             


Asn Ile Glu Asp Phe Leu Asn Ser Arg Asn Ser Asn Phe Asp Asn Arg 
    210                 215                 220                 


Phe Asp Glu Ser Val Asp Gly Phe Cys Ser Asn Leu Gly Gln Ala Cys 
225                 230                 235                 240 


Gly Asn Lys Asp Ile Pro Leu Pro Lys Glu Thr Ser Ser Ile Arg Asn 
                245                 250                 255     


Pro Gly Val Ile Asp Ser Leu Ser Asn Phe Asn Ser Asn Ser Asp Ile 
            260                 265                 270         


Gln Thr Leu Phe Ser Pro Asn Ser Leu Gln Asn Asp Pro Leu Ala Glu 
        275                 280                 285             


Phe Asp Pro Thr Pro Ile Asp Gln Asn Leu Val Phe Gly Leu Asn Ala 
    290                 295                 300                 


Pro Glu Thr Asn Leu Asp Gly Leu Phe Gly Asp Phe Asn Lys Tyr His 
305                 310                 315                 320 


Thr Asp Pro Leu Ala Ser Leu Val Thr Glu Glu Ser Ile Phe Asp Pro 
                325                 330                 335     


Leu Arg Ala Thr Ser Asn Ser Val Ser His Ser Lys Pro Asn Pro Ile 
            340                 345                 350         


Thr Thr Thr Ser Leu His Asn Leu Glu Ala Lys His Lys Val Pro Glu 
        355                 360                 365             


Ala Asp Glu Asp Cys Asn Asp Asn Leu Asp Asn Met Val Val Pro Asn 
    370                 375                 380                 


Arg Glu Gly Ser Leu Leu Lys Cys Ser Glu Ile Trp Glu Arg Ile Thr 
385                 390                 395                 400 


Thr His Pro Arg Tyr Ser Glu Ile Asp Ile Asp Gly Leu Cys Met Glu 
                405                 410                 415     


Leu Lys His Lys Ala Lys Cys Ser Glu Ser Gly Val Val Val Asp Asp 
            420                 425                 430         


Ala Asp Val Asp Ser Leu Leu Gln Arg Ala Ala Leu Lys Tyr Pro Ile 
        435                 440                 445             


Lys Thr Glu Pro Asp Val Val Asp Phe Ser Met Phe Lys 
    450                 455                 460     


<210>  24
<211>  387
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Thr Glu Phe Glu Leu Pro Pro Lys Tyr Ile Thr Ala Ala Asn Asp 
1               5                   10                  15      


Leu Arg Ser Asp Thr Phe Thr Thr Pro Thr Ala Glu Met Ile Gln Ala 
            20                  25                  30          


Ala Leu Glu Ala Ser Ile Gly Asp Ala Val Tyr Gly Glu Asp Val Asp 
        35                  40                  45              


Thr Val Arg Leu Glu Gln Thr Val Ala Arg Met Ala Gly Lys Glu Ala 
    50                  55                  60                  


Gly Leu Phe Cys Val Ser Gly Thr Leu Ser Asn Gln Ile Ala Ile Arg 
65                  70                  75                  80  


Thr His Leu Met Gln Pro Pro Tyr Ser Ile Leu Cys Asp Tyr Arg Ala 
                85                  90                  95      


His Val Tyr Thr His Glu Ala Ala Gly Leu Ala Ile Leu Ser Gln Ala 
            100                 105                 110         


Met Val Val Pro Val Val Pro Ser Asn Gly Asp Tyr Leu Thr Leu Glu 
        115                 120                 125             


Asp Ile Lys Ser His Tyr Val Pro Asp Asp Gly Asp Ile His Gly Ala 
    130                 135                 140                 


Pro Thr Arg Leu Ile Ser Leu Glu Asn Thr Leu His Gly Ile Val Tyr 
145                 150                 155                 160 


Pro Leu Glu Glu Leu Val Arg Ile Lys Ala Trp Cys Met Glu Asn Gly 
                165                 170                 175     


Leu Lys Leu His Cys Asp Gly Ala Arg Ile Trp Asn Ala Ala Ala Gln 
            180                 185                 190         


Ser Gly Val Pro Leu Lys Gln Tyr Gly Glu Ile Phe Asp Ser Ile Ser 
        195                 200                 205             


Ile Cys Leu Ser Lys Ser Met Gly Ala Pro Ile Gly Ser Val Leu Val 
    210                 215                 220                 


Gly Asn Leu Lys Phe Val Lys Lys Ala Thr His Phe Arg Lys Gln Gln 
225                 230                 235                 240 


Gly Gly Gly Ile Arg Gln Ser Gly Met Met Ala Arg Met Ala Leu Val 
                245                 250                 255     


Asn Ile Asn Asn Asp Trp Lys Ser Gln Leu Leu Tyr Ser His Ser Leu 
            260                 265                 270         


Ala His Glu Leu Ala Glu Tyr Cys Glu Ala Lys Gly Ile Pro Leu Glu 
        275                 280                 285             


Ser Pro Ala Asp Thr Asn Phe Val Phe Ile Asn Leu Lys Ala Ala Arg 
    290                 295                 300                 


Met Asp Pro Asp Val Leu Val Lys Lys Gly Leu Lys Tyr Asn Val Lys 
305                 310                 315                 320 


Leu Met Gly Gly Arg Val Ser Phe His Tyr Gln Val Thr Arg Asp Thr 
                325                 330                 335     


Leu Glu Lys Val Lys Leu Ala Ile Ser Glu Ala Phe Asp Tyr Ala Lys 
            340                 345                 350         


Glu His Pro Phe Asp Cys Asn Gly Pro Thr Gln Ile Tyr Arg Ser Glu 
        355                 360                 365             


Ser Thr Glu Val Asp Val Asp Gly Asn Ala Ile Arg Glu Ile Lys Thr 
    370                 375                 380                 


Tyr Lys Tyr 
385         


<210>  25
<211>  387
<212>  PRT
<213>  Saccharomyces bayanus

<400>  25

Met Thr Glu Phe Glu Leu Pro Pro Lys Tyr Ile Thr Ala Ala Asn Asp 
1               5                   10                  15      


Leu Arg Ser Asp Thr Phe Thr Thr Pro Thr Ala Glu Met Met Gln Ala 
            20                  25                  30          


Ala Leu Glu Ala Ser Ile Gly Asp Ala Val Tyr Gly Glu Asp Val Asp 
        35                  40                  45              


Thr Val Arg Leu Glu Gln Thr Val Ala Arg Met Ala Gly Lys Glu Ala 
    50                  55                  60                  


Gly Leu Phe Cys Val Ser Gly Thr Leu Ser Asn Gln Ile Ala Ile Arg 
65                  70                  75                  80  


Thr His Leu Met Gln Pro Pro Tyr Ser Ile Leu Cys Asp Tyr Arg Ala 
                85                  90                  95      


His Val Tyr Thr His Glu Ala Ala Gly Leu Ala Ile Leu Ser Gln Ala 
            100                 105                 110         


Met Val Val Pro Val Val Pro Ser Asn Gly Asp Tyr Leu Thr Leu Glu 
        115                 120                 125             


Asp Ile Lys Ser His Tyr Val Pro Asp Asp Gly Asp Ile His Gly Ala 
    130                 135                 140                 


Pro Thr Arg Leu Ile Ser Leu Glu Asn Thr Leu His Gly Ile Val Tyr 
145                 150                 155                 160 


Pro Leu Glu Glu Leu Val Arg Ile Lys Ala Trp Cys Met Glu Asn Gly 
                165                 170                 175     


Leu Lys Leu His Cys Asp Gly Ala Arg Ile Trp Asn Ala Ala Ala Gln 
            180                 185                 190         


Ser Gly Val Pro Leu Lys Gln Tyr Gly Glu Ile Phe Asp Ser Ile Ser 
        195                 200                 205             


Ile Cys Leu Ser Lys Ser Met Gly Ala Pro Ile Gly Ser Val Leu Val 
    210                 215                 220                 


Gly Asn Leu Lys Phe Val Lys Lys Ala Thr His Phe Arg Lys Gln Gln 
225                 230                 235                 240 


Gly Gly Gly Ile Arg Gln Ser Gly Met Met Ala Arg Met Ala Leu Val 
                245                 250                 255     


Asn Ile Asn Asn Asp Trp Lys Ser Gln Leu Leu Tyr Ser His Ser Leu 
            260                 265                 270         


Ala His Glu Leu Ala Glu Tyr Cys Glu Ala Lys Gly Ile Pro Leu Glu 
        275                 280                 285             


Ser Pro Ala Asp Thr Asn Phe Val Phe Ile Asn Leu Lys Ala Ala Arg 
    290                 295                 300                 


Met Asp Pro Asp Val Leu Val Lys Lys Gly Leu Lys Tyr Asn Val Lys 
305                 310                 315                 320 


Leu Met Gly Gly Arg Val Ser Phe His Tyr Gln Val Thr Arg Asp Thr 
                325                 330                 335     


Leu Glu Lys Val Lys Leu Ala Ile Ser Glu Ala Phe Asp Tyr Ala Lys 
            340                 345                 350         


Glu His Pro Phe Asp Cys Asn Gly Pro Thr Gln Ile Tyr Arg Ser Glu 
        355                 360                 365             


Ser Thr Glu Val Asp Val Asp Gly Asn Ala Ile Arg Glu Ile Lys Thr 
    370                 375                 380                 


Tyr Lys Tyr 
385         


<210>  26
<211>  387
<212>  PRT
<213>  Saccharomyces kudriavzevii

<400>  26

Met Thr Glu Phe Glu Leu Pro Pro Lys Tyr Thr Thr Ala Ala Asn Asp 
1               5                   10                  15      


Leu Arg Ser Asp Thr Phe Thr Thr Pro Thr Pro Glu Met Met Gln Ala 
            20                  25                  30          


Ala Leu Glu Ala Ser Ile Gly Asp Ala Val Tyr Gly Glu Asp Val Asp 
        35                  40                  45              


Thr Val Arg Leu Glu Gln Thr Val Ala Arg Met Ala Ala Lys Glu Ala 
    50                  55                  60                  


Gly Leu Phe Cys Val Ser Gly Thr Leu Ser Asn Gln Ile Ala Ile Arg 
65                  70                  75                  80  


Thr His Leu Thr Gln Pro Pro Tyr Ser Ile Leu Cys Asp Tyr Arg Ala 
                85                  90                  95      


His Val Tyr Thr His Glu Ala Ala Gly Leu Ala Ile Leu Ser Gln Ala 
            100                 105                 110         


Met Val Val Pro Val Ile Pro Ser Asn Gly Asp Tyr Leu Thr Leu Glu 
        115                 120                 125             


Asp Ile Arg Ser His Tyr Val Pro Asp Asp Gly Asp Ile His Gly Ala 
    130                 135                 140                 


Pro Thr Arg Leu Ile Ser Leu Glu Asn Thr Leu His Gly Ile Val Tyr 
145                 150                 155                 160 


Pro Leu Glu Glu Leu Val Arg Ile Lys Ala Trp Cys Met Glu Asn Gly 
                165                 170                 175     


Leu Lys Leu His Cys Asp Gly Ala Arg Ile Trp Asn Ala Ala Ala Gln 
            180                 185                 190         


Ser Gly Val Pro Leu Lys Gln Tyr Gly Glu Ile Phe Asp Ser Ile Ser 
        195                 200                 205             


Ile Cys Leu Ser Lys Ser Met Gly Ala Pro Ile Gly Ser Val Leu Val 
    210                 215                 220                 


Gly Asn Leu Lys Phe Val Lys Lys Ala Thr His Phe Arg Lys Gln Gln 
225                 230                 235                 240 


Gly Gly Gly Ile Arg Gln Ser Gly Met Met Ala Arg Met Ala Leu Val 
                245                 250                 255     


Asn Ile Asn Asn Asp Trp Lys Ser Gln Leu Leu Tyr Ser His Ser Leu 
            260                 265                 270         


Ala His Glu Leu Ala Gln Phe Cys Lys Ala Lys Gly Ile Pro Leu Glu 
        275                 280                 285             


Ser Pro Ala Asp Thr Asn Phe Val Phe Ile Asn Leu Lys Ser Ala Arg 
    290                 295                 300                 


Met Asp Pro Asp Val Leu Val Lys Lys Gly Leu Lys Tyr Asn Val Lys 
305                 310                 315                 320 


Leu Met Gly Gly Arg Val Ser Phe His Tyr Gln Ile Thr Arg Asp Thr 
                325                 330                 335     


Leu Glu Lys Val Lys Leu Ala Ile Ser Glu Ala Phe Asp Tyr Ala Lys 
            340                 345                 350         


Glu His Pro Phe Asp Ser Asn Gly Pro Thr Lys Ile Tyr Arg Ser Glu 
        355                 360                 365             


Ser Thr Glu Val Asp Val Asp Gly Asn Ala Ile His Glu Ile Lys Thr 
    370                 375                 380                 


Tyr Lys Tyr 
385         


<210>  27
<211>  371
<212>  PRT
<213>  Cyberlindnera jadinii

<400>  27

Met Thr Val Ala Glu Leu Lys Pro Tyr Gln Ser Ala Ser Asn Asp Phe 
1               5                   10                  15      


Arg Ser Asp Thr Phe Thr Thr Pro Thr Glu Ala Met Ile Lys Ala Ala 
            20                  25                  30          


Leu Thr Ala Ser Ile Gly Asp Ser Val Tyr Asn Glu Asp Val Asp Thr 
        35                  40                  45              


Ile Ala Leu Glu Gln Lys Val Ala Lys Leu Ala Gly Lys Pro Ala Gly 
    50                  55                  60                  


Leu Tyr Cys Val Ser Gly Thr Leu Ser Asn Gln Ile Ala Ile Arg Thr 
65                  70                  75                  80  


His Leu Phe Gln Pro Pro Tyr Ser Ile Leu Cys Asp Tyr Arg Ala His 
                85                  90                  95      


Val Tyr Thr His Glu Ala Ala Gly Leu Ala Met Leu Ser Asn Ala Met 
            100                 105                 110         


Val Val Pro Val Arg Pro Ser Asn Gly Asp Tyr Leu Thr Leu Glu Asp 
        115                 120                 125             


Ile Lys Lys Asn Leu Val Pro Glu Asp Gly Asp Ile His Gly Ala Pro 
    130                 135                 140                 


Thr Lys Leu Ile Ser Leu Glu Asn Thr Leu His Gly Ile Val Tyr Pro 
145                 150                 155                 160 


Tyr Glu Glu Leu Leu Arg Ile Lys Gln Phe Cys Val Glu Asn Gly Tyr 
                165                 170                 175     


Lys Leu His Cys Asp Gly Ala Arg Ile Trp Asn Ala Ser Val Glu Thr 
            180                 185                 190         


Gly Val Pro Leu His Lys Tyr Gly Glu Ile Phe Asp Ser Ile Ser Ile 
        195                 200                 205             


Cys Leu Ser Lys Ser Ile Gly Ala Pro Met Gly Ser Val Leu Val Gly 
    210                 215                 220                 


Glu Leu Pro Phe Ile Lys Lys Cys Asn His Phe Lys Lys Gln Cys Gly 
225                 230                 235                 240 


Gly Gly Ile Arg Gln Ser Gly Met Met Ala Lys Met Ala Met Val Ala 
                245                 250                 255     


Ile Glu Asp Asn Leu Pro Leu Leu Lys Ser Ser His Glu Lys Ala Lys 
            260                 265                 270         


Asn Leu Gly Asp Phe Cys Ile Glu Asn Gly Ile Val Leu Glu Ser Pro 
        275                 280                 285             


Val Asp Thr Asn Phe Val Phe Ile Asp Leu Glu Ala Asn Tyr Ile Lys 
    290                 295                 300                 


Asp Asp Asp Leu Ile Lys Phe Gly Lys Lys His Asn Val Asn Leu Met 
305                 310                 315                 320 


Gly Gly Arg Ile Ala Phe His Tyr Gln Ile Ser Asp Glu Ala Leu Glu 
                325                 330                 335     


Asn Val Lys Leu Ala Val Trp Asp Ala Phe Glu Asn Ala Lys Lys Asn 
            340                 345                 350         


Pro Tyr Val His Asp Gly Pro Tyr Lys Met Tyr Arg Ser Pro Thr Pro 
        355                 360                 365             


Val Lys Tyr 
    370     


<210>  28
<211>  387
<212>  PRT
<213>  Torulaspora delbrueckii

<400>  28

Met Thr Ser Gln Leu Pro Leu Ala Tyr Ala Ser Ala Ser Asn Asp Leu 
1               5                   10                  15      


Arg Ser Asp Thr Phe Thr Thr Pro Thr Pro Glu Met Ile Glu Ala Ala 
            20                  25                  30          


Leu Thr Ala Ser Ile Gly Asp Ala Val Tyr Gln Glu Asp Met Asp Thr 
        35                  40                  45              


Cys Phe Leu Glu Asn Leu Val Ala Asn Leu Ala Gly Lys Glu Gln Gly 
    50                  55                  60                  


Leu Phe Cys Val Ser Gly Thr Leu Ser Asn Gln Ile Ala Leu Arg Thr 
65                  70                  75                  80  


His Leu Leu Gln Pro Pro Tyr Ser Val Leu Cys Asp Tyr Arg Ala His 
                85                  90                  95      


Val Tyr Thr His Glu Ala Ala Gly Leu Ala Ile Leu Ser Gln Ala Met 
            100                 105                 110         


Val Val Pro Val Arg Pro Ala Asn Gly Asn Tyr Leu Thr Leu Asp Asp 
        115                 120                 125             


Ile Thr Ala His Tyr Val Pro Asp Asp Gly Asp Val His Gly Ala Pro 
    130                 135                 140                 


Thr Lys Val Ile Ser Leu Glu Asn Thr Leu His Gly Met Ile Thr Pro 
145                 150                 155                 160 


Ile Asp Glu Leu Val Arg Ile Arg Ala Trp Cys Ser Gln Asn Asn Ile 
                165                 170                 175     


Lys Leu His Cys Asp Gly Ala Arg Ile Trp Asn Ala Ala Ile Ala Ser 
            180                 185                 190         


Gly Val Pro Leu Lys Gln Phe Gly Glu Leu Phe Asp Ser Ile Ser Ile 
        195                 200                 205             


Cys Leu Ser Lys Ser Met Gly Ala Pro Ile Gly Ser Ile Leu Val Gly 
    210                 215                 220                 


Asp Ala Lys Phe Ile Lys Lys Ala Asn His Phe Arg Lys Gln Gln Gly 
225                 230                 235                 240 


Gly Gly Ile Arg Gln Ser Gly Met Met Ala Lys Met Ala Thr Val Ala 
                245                 250                 255     


Ile Asn Gly Asp Trp Lys Ala Lys Met Ser Tyr Ser His Arg Leu Ala 
            260                 265                 270         


Ser Asp Leu Ala Leu Phe Cys Lys Glu Asn Asp Ile Pro Leu Glu Ser 
        275                 280                 285             


Pro Thr Asp Thr Asn Phe Val Phe Leu Asp Leu Ser Lys Ala His Met 
    290                 295                 300                 


Asn Pro Asp Val Leu Val Lys Lys Gly Leu Lys Tyr Arg Ile Lys Leu 
305                 310                 315                 320 


Met Gly Gly Arg Ile Ala Phe His Tyr Gln Val Thr Gln Glu Thr Leu 
                325                 330                 335     


Glu Lys Ala Lys Cys Ala Ile Leu Glu Ser Phe Glu His Ala Lys Glu 
            340                 345                 350         


His Pro Phe Asn Gln Gln Gly Gln Thr Lys Ile Tyr Arg Ser Glu Ser 
        355                 360                 365             


Thr Asp Lys Ile Asp Ile Asp Gly Asn Ser Ile His Gly Ile Lys Thr 
    370                 375                 380                 


Tyr Lys Tyr 
385         


<210>  29
<211>  388
<212>  PRT
<213>  Zygosaccharomyces bailii

<400>  29

Met Pro Asp Tyr Glu Leu Pro Pro Val Tyr Thr Thr Ala Ser Asn Asp 
1               5                   10                  15      


Leu Arg Ser Asp Thr Phe Thr Thr Pro Thr Pro Glu Met Met Gln Ala 
            20                  25                  30          


Gly Ile Ala Ala Ser Ile Gly Asp Ala Val Tyr Gln Glu Asp Ile Asp 
        35                  40                  45              


Thr Ile Arg Leu Glu Gln Thr Val Ala Gln Leu Ala Gly Lys Glu Ala 
    50                  55                  60                  


Gly Leu Phe Cys Val Ser Gly Thr Leu Ser Asn Gln Ile Ala Val Arg 
65                  70                  75                  80  


Thr His Leu Thr Gln Pro Pro Tyr Ser Val Leu Cys Asp Tyr Arg Ser 
                85                  90                  95      


His Val Tyr Thr His Glu Ala Ala Gly Leu Ala Ile Leu Ser Gln Ala 
            100                 105                 110         


Met Val Val Pro Val Val Pro Ser Asn Gly Asn Tyr Met Thr Leu Glu 
        115                 120                 125             


Asp Ile Lys Arg His Tyr Val Pro Asp Asp Gly Asp Ile His Gly Ala 
    130                 135                 140                 


Pro Thr Arg Leu Val Ser Leu Glu Asn Thr Leu His Gly Ile Val Tyr 
145                 150                 155                 160 


Pro Leu Glu Glu Leu Leu Arg Ile Arg Ala Trp Cys Leu Glu Asn Asp 
                165                 170                 175     


Ile Arg Ile His Cys Asp Gly Ala Arg Leu Trp Asn Ala Ser Val Ala 
            180                 185                 190         


Ala Gly Val Pro Met Arg Gln Phe Gly Glu Leu Phe Asp Ser Ile Ser 
        195                 200                 205             


Ile Cys Leu Ser Lys Ser Met Gly Ala Pro Ile Gly Ser Val Leu Val 
    210                 215                 220                 


Gly Asp Leu Lys Phe Ile Lys Lys Cys Asn His Phe Arg Lys Gln Gln 
225                 230                 235                 240 


Gly Gly Gly Ile Arg Gln Ser Gly Met Met Cys Ala Met Ala Leu Thr 
                245                 250                 255     


Thr Val Thr Gly Asp Trp Lys Ser Lys Leu Leu His Ser His Gln Leu 
            260                 265                 270         


Ala His Glu Leu Ala Arg Phe Cys Ile Glu Lys Gly Ile Pro Leu Glu 
        275                 280                 285             


Ser Pro Ala Asp Thr Asn Phe Val Phe Ile Ser Leu Ser Gln Ala Lys 
    290                 295                 300                 


Met Asp Pro Asp Val Leu Val Lys Lys Gly Leu Lys Tyr Gly Val Lys 
305                 310                 315                 320 


Phe Met Gly Gly Arg Ile Ala Phe His Tyr Gln Val Asn Arg Asp Thr 
                325                 330                 335     


Leu Glu Lys Ala Lys Met Ala Ile Leu Glu Thr Phe Glu Tyr Ala Lys 
            340                 345                 350         


Glu His Pro Phe Asn Ser Glu Gly Glu Thr Lys Ile Tyr Arg Ser Glu 
        355                 360                 365             


Ser Thr Glu Arg Val Asp Ile Asp Gly Arg Pro Ile His Asp Ile Lys 
    370                 375                 380                 


Thr Tyr Lys Tyr 
385             


<210>  30
<211>  376
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  30

Met Ser Gly Ser Val Thr Ser Thr Thr Thr Glu Thr Arg Leu Cys Pro 
1               5                   10                  15      


Ser Asn Gln Gly Ser Ala Lys Lys Tyr Arg Pro Trp Asn Asp Phe Arg 
            20                  25                  30          


Ser Asp Thr Leu Thr Val Pro Thr Asp Glu Met Arg Arg Ile Met Tyr 
        35                  40                  45              


Glu Ala Ser Asp Gly Asp Cys Val Tyr Glu Glu Asp Glu Asp Thr Arg 
    50                  55                  60                  


Lys Leu Glu Val Tyr Val Ala Lys Leu Thr Gly Lys Glu Ala Ala Leu 
65                  70                  75                  80  


Phe Val Thr Ser Gly Thr Gln Gly Asn Gln Leu Cys Ile Arg Ser His 
                85                  90                  95      


Leu His Gln Pro Pro His Ser Ile Ile Cys Asp Asp Arg Ala His Ile 
            100                 105                 110         


Tyr Asn Trp Glu Ala Gly Ala Ile Gly Leu Phe Thr Gln Ala Ile Val 
        115                 120                 125             


Arg Pro Ile Ser Pro Lys Asn Asn Val Tyr Ile Thr Ala Glu Glu Ile 
    130                 135                 140                 


Glu Asn Lys Leu Ile Leu Gly Asn Asp Ile His Phe Ser Pro Thr Gly 
145                 150                 155                 160 


Leu Ile Cys Leu Glu Asn Thr Ile Lys Gly Ala Val Val Pro Leu Asp 
                165                 170                 175     


Glu Val Ala Arg Ile Ser Gly Leu Ala Lys Ala His Lys Ile Pro Leu 
            180                 185                 190         


His Cys Asp Gly Ala Arg Leu Trp Asp Ala Ala Val Ala Ser Asn Val 
        195                 200                 205             


Ser Ile Lys Glu Tyr Cys Ser Tyr Phe Asp Ser Val Ser Leu Cys Leu 
    210                 215                 220                 


Ser Lys Gly Leu Ala Ala Pro Val Gly Ser Ile Ile Val Gly Pro Arg 
225                 230                 235                 240 


Asp Phe Ile Ala Lys Ala Lys Trp Phe Arg Lys Ala Tyr Gly Gly Gly 
                245                 250                 255     


Leu Arg Gln Ser Gly Met Leu Ala Ala Ala Gly Leu Tyr Ser Ile Gln 
            260                 265                 270         


His Asn Phe Pro Leu Leu Lys Gln Val His Lys Tyr Ala Ile Glu Val 
        275                 280                 285             


Ala Glu Tyr Ala Glu Ser Leu Gly Ile Glu Leu Glu Val Pro Thr Gln 
    290                 295                 300                 


Ser Asn Met Val Thr Leu Ala Asn Ile Asn Val Ala Ile Leu Cys Asp 
305                 310                 315                 320 


Glu Ala Lys Lys Ser Gly Ile Ile Leu Met Gly Pro Arg Ile Val Phe 
                325                 330                 335     


His Ile Gln Ile Thr Pro Asp Ala Val Glu Ile Leu Lys Asn Val Leu 
            340                 345                 350         


Arg Arg Thr Val Glu Arg Gln Ala Val Glu Thr His Ile Val Ala Lys 
        355                 360                 365             


Pro Gly Glu Phe Cys Val Gly Tyr 
    370                 375     


<210>  31
<211>  395
<212>  PRT
<213>  Kluyveromyces lactis

<400>  31

Met Thr Ala Ser Asp Lys Lys Ser Thr Ala Ala Ala Pro Ser Glu Pro 
1               5                   10                  15      


Ala Tyr Thr Ser Ala Ala Asn Asp Leu Arg Ser Asp Thr Phe Thr Thr 
            20                  25                  30          


Pro Thr Lys Glu Met Leu Glu Ala Ala Phe Asn Ala Ser Ile Gly Asp 
        35                  40                  45              


Ala Val Tyr Asn Glu Asp Val Asp Thr Ile Glu Leu Glu Thr Val Val 
    50                  55                  60                  


Ala Arg Leu Ala Gly Lys Glu Ala Gly Leu Phe Cys Val Ser Gly Thr 
65                  70                  75                  80  


Leu Ser Asn Gln Ile Gly Leu Arg Thr His Leu Phe Gln Pro Pro Tyr 
                85                  90                  95      


Ser Ile Leu Cys Asp Tyr Arg Ala His Val Tyr Thr His Glu Ala Ala 
            100                 105                 110         


Gly Leu Ala Ile Leu Ser Gln Ala Met Val Thr Pro Val Ile Pro Ser 
        115                 120                 125             


Asn Gly Asp Tyr Met Thr Leu Glu Asp Ile Lys Ala His Tyr Ile Pro 
    130                 135                 140                 


Asp Asp Gly Asp Ile His Gly Ala Pro Thr Arg Val Leu Ser Leu Glu 
145                 150                 155                 160 


Asn Thr Leu His Gly Ile Val Tyr Pro Leu Glu Glu Leu Ile Arg Ile 
                165                 170                 175     


Lys Gly Trp Cys Leu Glu Asn Asp Ile Lys Leu His Cys Asp Gly Ala 
            180                 185                 190         


Arg Ile Trp Asn Ala Val Val Glu Ser Gly Val Ser Leu Lys Gln Tyr 
        195                 200                 205             


Gly Glu Ile Phe Asp Ser Ile Ser Ile Cys Leu Ser Lys Ser Met Gly 
    210                 215                 220                 


Ala Pro Met Gly Ser Val Leu Val Gly Ser Asn Lys Phe Val Lys Lys 
225                 230                 235                 240 


Cys Asn His Phe Arg Lys Gln Gln Gly Gly Gly Val Arg Gln Ser Gly 
                245                 250                 255     


Ile Met Cys Arg Met Ala Leu Cys Ala Val Asn Gly Asp Trp Lys Thr 
            260                 265                 270         


Lys Met Gly Tyr Ser His Gln Leu Ala His Glu Leu Ala Lys Phe Cys 
        275                 280                 285             


Lys Asp Asn Gly Ile Pro Leu Glu Ser Pro Ala Asp Thr Asn Phe Val 
    290                 295                 300                 


Phe Leu Asp Leu Gln Lys Ala Lys Met Asn Pro Asp Val Leu Val Lys 
305                 310                 315                 320 


Lys Gly Leu Lys Tyr Gly Val Lys Leu Met Gly Gly Arg Val Ser Phe 
                325                 330                 335     


His Tyr Gln Val Thr Arg Glu Thr Leu Glu Asn Val Lys Ser Ala Val 
            340                 345                 350         


Leu Glu Thr Phe Gln Tyr Ala Lys Glu Asn Pro Phe Asp Thr Asn Gly 
        355                 360                 365             


Pro Thr Lys Ile Tyr Arg Ser Glu Ser Thr Asp Phe Asp Ile His Gly 
    370                 375                 380                 


Asn Pro Ile Ser Asp Ile Lys Thr Tyr Lys Tyr 
385                 390                 395 


<210>  32
<211>  372
<212>  PRT
<213>  Pichia pastoris

<400>  32

Met Thr Lys Glu Asp Phe Pro Cys Ala Asn Glu Phe Arg Ser Asp Thr 
1               5                   10                  15      


Phe Thr Val Pro Thr Ala Ser Met Ile Gln Ser Val Ala Leu Ala Ser 
            20                  25                  30          


Val Gly Asp Ser Val Tyr Ala Glu Asp Leu Asp Thr Leu Asn Leu Glu 
        35                  40                  45              


Glu Lys Val Ala Gln Met Ala Asp Lys Glu Ala Gly Leu Phe Cys Val 
    50                  55                  60                  


Ser Gly Thr Leu Ser Asn Gln Ile Gly Leu Arg Ser His Leu Met Gln 
65                  70                  75                  80  


Pro Pro His Arg Ile Leu Cys Asp Ser Arg Ala His Val Tyr Met His 
                85                  90                  95      


Glu Ala Gly Gly Leu Ala Thr Leu Ser Gln Ala Met Val Thr Pro Val 
            100                 105                 110         


Thr Pro Arg Asn Gly Leu Tyr Leu Thr Leu Glu Asp Val Val Asp Asn 
        115                 120                 125             


Tyr Ile Pro Asp Asp Gly Asp Ile His Met Ala Pro Thr Lys Val Val 
    130                 135                 140                 


Ser Leu Glu Asn Thr Ile His Gly Ile Ile Thr Pro Leu Glu Glu Ile 
145                 150                 155                 160 


Ala Arg Ile Ser Glu Trp Cys Arg Glu Asn Asp Val Arg Leu His Cys 
                165                 170                 175     


Asp Gly Ala Arg Leu Trp Asn Ala Ser Val Glu Thr Asn Thr Pro Leu 
            180                 185                 190         


Ser Glu Tyr Gly Lys Leu Phe Asp Ser Ile Ser Leu Cys Leu Ser Lys 
        195                 200                 205             


Ser Leu Gly Ser Pro Met Gly Ser Val Leu Val Gly Asp Arg Lys Phe 
    210                 215                 220                 


Ile Asp Lys Ala Asn His Phe Lys Lys Gln Asn Gly Gly Gly Ile Arg 
225                 230                 235                 240 


Gln Ser Gly Phe Ile Ala Arg Met Ala Ser Ile Ala Ile Asp Glu Asn 
                245                 250                 255     


Leu Gly Lys Leu Arg Gln Ser His Glu Tyr Ala Lys Asp Val Ala Arg 
            260                 265                 270         


Phe Leu Gln Asp Asn Gly Val Pro Leu Glu Cys Pro Thr His Thr Asn 
        275                 280                 285             


Phe Val Phe Val Asp Gln Lys Lys Ala Arg Ile Asp Pro Asp His Leu 
    290                 295                 300                 


Val Ala Met Gly Glu Lys Tyr Asn Val Asn Ile Met Gly Thr Arg Phe 
305                 310                 315                 320 


Ala Phe His Phe Gln Asn Ser Lys Glu Ala Val Glu Arg Leu Lys Gln 
                325                 330                 335     


Ala Ile Met Glu Thr Phe Lys Tyr Ser Gln Glu His Pro Tyr Val Ser 
            340                 345                 350         


Thr Gly Ala Lys Arg Leu Tyr Thr Ser Lys Ser Arg Ser Asn Ser Pro 
        355                 360                 365             


Val Leu Lys Asn 
    370         


