                               SEQUENCE LISTING

<110> STCUBE, INC.
      BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
 
<120> DUAL FUNCTION ANTIBODIES SPECIFIC TO GLYCOSYLATED PD-L1 AND 
      METHODS OF USE THEREOF

<130> 24258.105007

<140>
<141>

<150> 62/361,312
<151> 2016-07-12

<150> 62/314,652
<151> 2016-03-29

<160> 100   

<170> PatentIn version 3.5

<210> 1
<211> 290
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210> 2
<211> 350
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
aagtgcagct ggtggagtct gggggagcct tagtgaagcc tggagggtcc ctgaaactct       60

cctgtgcagc ctctggattc actttcagta actctgccat gtcttgggtt cgccagactc      120

cagagaagag gctggagtgg gtcgcaacca ttagtagtgc tggtagttat acctactatc      180

cagacagtgt gaagggtcga ttcaccatct ccagagacaa tgccaagaac accctgtacc      240

tgcaaatgag cagtctgagg tctgaggaca cggccttgta ttactgtaca agacattatg      300

attactactt tgactactgg ggccaaggcg ccactctcac agtctcctca                 350


<210> 3
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ala Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Tyr Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ala Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Phe Thr Phe Ser Asn Ser 
1               5           


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Asn Ser Ala Met Ser 
1               5   


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ser Ser Gly Gly Ser Tyr 
1               5       


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Thr Ile Ser Ser Ala Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 8
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Thr Arg His Tyr Asp Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Thr Arg His Tyr Asp Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 10
<211> 319
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ttgacctgca gtgccagctc aagtgtaagt tacatgcatt ggtaccagca gaagccagga      120

tcctccccca gactcgtgat ttatgacaca tccaacctgg cttctggagt ccctgttcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacag tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtgatcacc cgctcacgtt cggtgctggg      300

accaagctgg agctgaaac                                                   319


<210> 11
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Val Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Asp His Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210> 12
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gln Gln Trp Ser Asp His Pro Leu Thr 
1               5                   


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Gln Gln Trp Ser Asp His Pro Leu Thr 
1               5                   


<210> 18
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
gaagtgatgc tggtggagtc tgggggagcc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cttctggatt cagtttgagt aactatgtca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtaggta tatctactat      180

acagacagtg tgaagggtcg attcaccatc tccagggaca atgccaggaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccatgt attattgtgc aagagacggt      300

agtaccttgt actactttga ctattggggc caaggcacca ctctcacagt ctcctca         357


<210> 19
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Arg Tyr Ile Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ser Thr Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Gly Phe Ser Leu Ser Asn Tyr 
1               5           


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Asn Tyr Val Met Ser 
1               5   


<210> 22
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ser Ser Gly Gly Arg Tyr 
1               5       


<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Thr Ile Ser Ser Gly Gly Arg Tyr Ile Tyr Tyr Thr Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Asp Gly Ser Thr Leu Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 25
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Asp Gly Ser Thr Leu Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210> 26
<211> 378
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
caagtgcaga ttttcagctt cctgctaatc agtgcctcag tcatactgtc cagaggacaa       60

actgttctca cccagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg      120

acctgcagtg ccagctcaag tgtagattac atgtactggt accagcagaa gccaggatcc      180

tcccccagac tcctgattta tgacacatcc aacctggctt ctggagtccc tgttcgcttc      240

agtggcagtg ggtctgggac ctcttactct ctcacaatca gccgaatgga ggctgaagat      300

gctgccactt attactgcca gcagtggagt agttccccac ccatcacgtt cggtactggg      360

accaaggtgg agctgaaa                                                    378


<210> 27
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser Val Ile Leu 
1               5                   10                  15      


Ser Arg Gly Gln Thr Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            20                  25                  30          


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        35                  40                  45              


Asp Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu 
    50                  55                  60                  


Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met 
                85                  90                  95      


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Ser 
            100                 105                 110         


Pro Pro Ile Thr Phe Gly Thr Gly Thr Lys Val Glu Leu Lys 
        115                 120                 125     


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Ser Ala Ser Ser Ser Val Asp Tyr Met Tyr 
1               5                   10  


<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ser Ala Ser Ser Ser Val Asp Tyr Met Tyr 
1               5                   10  


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Gln Gln Trp Ser Ser Ser Pro Pro Ile Thr 
1               5                   10  


<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Gln Gln Trp Ser Ser Ser Pro Pro Ile Thr 
1               5                   10  


<210> 34
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
tcaattgtca tattgctac                                                    19


<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
ttgactccat ctttcttca                                                    19


<210> 36
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
gtggtagagt atggtagcca aatgacaatt gaatgcaaa                              39


<210> 37
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
tttgcattca attgtcattt ggctaccata ctctaccac                              39


<210> 38
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
gagaggagaa gcttttccag gtgaccagca cactgag                                37


<210> 39
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
ctcagtgtgc tggtcacctg gaaaagcttc tcctctc                                37


<210> 40
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
gaccagcaca ctgagaatcc agacaacaac taatgagat                              39


<210> 41
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
atctcattag ttgttgtctg gattctcagt gtgctggtc                              39


<210> 42
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
gagagaggag aagcttttcc aagtgaccag cacactgaga                             40


<210> 43
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
tctcagtgtg ctggtcactt ggaaaagctt ctcctctctc                             40


<210> 44
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
gcataacgaa cctaaccctc ag                                                22


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
gcccaatgtc cactgtgata                                                   20


<210> 46
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
gtaacctcag tcacctgcc                                                    19


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
attccgctcc acaatctctg                                                   20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 48
tcttcaacct cacgctcaag                                                   20


<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 49
gtgtgcaaag acgtcatcat c                                                 21


<210> 50
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 50
caccatcacc ctcctttcta ttc                                               23


<210> 51
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 51
gaacaacagg tctgggattt ct                                                22


<210> 52
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 52
gccttttgcc atcgacatg                                                    19


<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 53
agtcagattc ttgcatccct g                                                 21


<210> 54
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
caaggagagc attaggacca ag                                                22


<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
ccccattaaa cctcaggact g                                                 21


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
tcgtcatggt gtggtattcc                                                   20


<210> 57
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
caggaagatg ggctgatcc                                                    19


<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 58
gaccgcactc atcttacacc                                                   20


<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 59
ggaggttggc tgaaggaata c                                                 21


<210> 60
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 60
tcccctgctt taaccatcg                                                    19


<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 61
ttgtcaccta tactggcgtt g                                                 21


<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 62
ctgagtgatg gaacgagtga g                                                 21


<210> 63
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
tagagatgac cagatgcaac g                                                 21


<210> 64
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
gagtccaact tcacggctta t                                                 21


<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 65
agtggtccag gaagacatag a                                                 21


<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 66
tgtgagggaa agatcaagtg g                                                 21


<210> 67
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 67
gctctccaag gtaaatgagg ac                                                22


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
ccactgagtt cgtcaagagg                                                   20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
acttccttgc catctgtcac                                                   20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 70
tggctcgctg ataagttctg                                                   20


<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 71
gtgagtctgg tttgggagaa g                                                 21


<210> 72
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 72
gcaaagacct gtacgccaac a                                                 21


<210> 73
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 73
tgcatcctgt cggcaatg                                                     18


<210> 74
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      consensus sequence


<220>
<221> MOD_RES
<222> (21)..(21)
<223> Ile, Met or Leu

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Asp or Asn

<400> 74
Ala Phe Thr Ile Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Xaa Glu Cys Arg Phe Pro Val Glu Lys Gln Leu Xaa 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210> 75
<211> 53
<212> PRT
<213> Homo sapiens

<400> 75
Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly 
    50              


<210> 76
<211> 53
<212> PRT
<213> Mus musculus

<400> 76
Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Arg Glu Leu Asp 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Glu Gln Val Ile 
        35                  40                  45              


Gln Phe Val Ala Gly 
    50              


<210> 77
<211> 53
<212> PRT
<213> Rattus norvegicus

<400> 77
Ala Phe Thr Ile Thr Ala Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Met Glu Cys Arg Phe Pro Val Glu Gln Lys Leu Asp 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Lys Glu Asp Lys Glu Val Ile 
        35                  40                  45              


Gln Phe Val Glu Gly 
    50              


<210> 78
<211> 53
<212> PRT
<213> Bos taurus

<400> 78
Ala Phe Thr Ile Thr Val Ser Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Arg Phe Pro Val Asp Lys Gln Leu Asn 
            20                  25                  30          


Leu Leu Val Leu Val Val Tyr Trp Glu Met Glu Asp Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210> 79
<211> 53
<212> PRT
<213> Sus scrofa

<400> 79
Ala Phe Thr Ile Thr Val Pro Lys Asp Met Tyr Glu Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Arg Phe Pro Val Asp Lys Gln Leu Asn 
            20                  25                  30          


Leu Leu Ala Leu Val Val Tyr Trp Glu Met Lys Asp Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210> 80
<211> 53
<212> PRT
<213> Equus caballus

<400> 80
Ala Phe Thr Ile Thr Val Thr Lys Asp Leu Tyr Val Val Asp Tyr Gly 
1               5                   10                  15      


Ser Asn Val Thr Ile Glu Cys Lys Phe Pro Val Glu Glu Pro Leu Asn 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asn Lys Lys Ile Ile 
        35                  40                  45              


Gln Phe Val Asn Gly 
    50              


<210> 81
<211> 23
<212> PRT
<213> Homo sapiens

<400> 81
Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys 
1               5                   10                  15      


Lys Phe Pro Val Glu Lys Gln 
            20              


<210> 82
<211> 11
<212> PRT
<213> Homo sapiens

<400> 82
Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile 
1               5                   10      


<210> 83
<211> 16
<212> PRT
<213> Homo sapiens

<400> 83
Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg 
1               5                   10                  15      


<210> 84
<211> 28
<212> PRT
<213> Homo sapiens

<400> 84
Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile Pro 
1               5                   10                  15      


Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr 
            20                  25              


<210> 85
<211> 61
<212> PRT
<213> Homo sapiens

<400> 85
Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg Gln 
1               5                   10                  15      


Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu 
            20                  25                  30          


Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys Met 
        35                  40                  45              


Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
    50                  55                  60      


<210> 86
<211> 21
<212> PRT
<213> Homo sapiens

<400> 86
Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr 
1               5                   10                  15      


Lys Arg Ile Thr Val 
            20      


<210> 87
<211> 408
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 87
atgaacttgt ggctcagctt ggttttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggagcctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtaac tctgccatgt cttgggttcg ccagactcca      180

gagaagaggc tggagtgggt cgcaaccatt agtagtgctg gtagttatac ctactatcca      240

gacagtgtga agggtcgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccttgtatt actgtacaag acattatgat      360

tactactttg actactgggg ccaaggcgcc actctcacag tctcctca                   408


<210> 88
<211> 136
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 88
Met Asn Leu Trp Leu Ser Leu Val Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Ser Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Ala Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Thr Arg His Tyr Asp Tyr Tyr Phe Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Ala Thr Leu Thr Val Ser Ser 
    130                 135     


<210> 89
<211> 385
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 89
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt catactgtcc       60

agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccttga cctgcagtgc cagctcaagt gtaagttaca tgcattggta ccagcagaag      180

ccaggatcct cccccagact cgtgatttat gacacatcca acctggcttc tggagtccct      240

gttcgcttca gtggcagtgg gtctgggacc tcttactctc tcacagtcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagtg atcacccgct cacgttcggt      360

gctgggacca agctggagct gaaac                                            385


<210> 90
<211> 128
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Leu Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Ser Ser 
    50                  55                  60                  


Pro Arg Leu Val Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Val 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Asp His Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


<210> 91
<211> 414
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 91
atgaacttcg ggctcagctt gattttcctt gtccttattt taaaaggtgt ccagtgtgaa       60

gtgatgctgg tggagtctgg gggagcctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagctt ctggattcag tttgagtaac tatgtcatgt cttgggttcg ccagactcca      180

gagaagaggc tggagtgggt cgcaaccatt agtagtggtg gtaggtatat ctactataca      240

gacagtgtga agggtcgatt caccatctcc agggacaatg ccaggaacac cctgtacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatgtatt attgtgcaag agacggtagt      360

accttgtact actttgacta ttggggccaa ggcaccactc tcacagtctc ctca            414


<210> 92
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 92
Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Met Leu Val Glu Ser Gly Gly Ala Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Asn Tyr Val Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Arg Tyr Ile Tyr Tyr Thr 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Gly Ser Thr Leu Tyr Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135             


<210> 93
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 93
His His His His His His 
1               5       


<210> 94
<211> 53
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      consensus sequence


<220>
<221> MOD_RES
<222> (12)..(12)
<223> Ile or Val

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Leu, Ala, Val or Tyr

<220>
<221> MOD_RES
<222> (45)..(45)
<223> Ala, Thr, Pro, Leu, Val or Ile

<220>
<221> MOD_RES
<222> (46)..(46)
<223> His, Arg, Asp or Val

<220>
<221> MOD_RES
<222> (48)..(48)
<223> Pro or Ala

<400> 94
Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Xaa Asn Ala Thr Ala 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Gly Pro Glu Glu Asn 
            20                  25                  30          


His Thr Ala Glu Leu Val Ile Pro Glu Leu Pro Xaa Xaa Xaa Pro Xaa 
        35                  40                  45              


Asn Lys Arg Thr His 
    50              


<210> 95
<211> 53
<212> PRT
<213> Homo sapiens

<400> 95
Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn 
            20                  25                  30          


His Thr Ala Glu Leu Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro 
        35                  40                  45              


Asn Glu Arg Thr His 
    50              


<210> 96
<211> 53
<212> PRT
<213> Mus musculus

<400> 96
Gly Met Leu Leu Asn Val Thr Ser Ser Leu Arg Val Asn Ala Thr Ala 
1               5                   10                  15      


Asn Asp Val Phe Tyr Cys Thr Phe Trp Arg Ser Gln Pro Gly Gln Asn 
            20                  25                  30          


His Thr Ala Glu Leu Ile Ile Pro Glu Leu Pro Ala Thr His Pro Pro 
        35                  40                  45              


Gln Asn Arg Thr His 
    50              


<210> 97
<211> 53
<212> PRT
<213> Rattus norvegicus

<400> 97
Glu Lys Leu Leu Asn Val Thr Ser Val Leu Arg Val Asn Ala Thr Ala 
1               5                   10                  15      


Asn Asp Val Phe His Cys Thr Phe Trp Arg Val His Ser Gly Glu Asn 
            20                  25                  30          


His Thr Ala Glu Leu Ile Ile Pro Glu Leu Pro Val Pro Arg Leu Pro 
        35                  40                  45              


His Asn Arg Thr His 
    50              


<210> 98
<211> 52
<212> PRT
<213> Bos taurus

<400> 98
Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Ala 
1               5                   10                  15      


Asp Lys Ile Phe Tyr Cys Thr Phe Arg Arg Leu Gly His Glu Glu Asn 
            20                  25                  30          


Asn Thr Ala Glu Leu Val Ile Pro Glu Pro Tyr Leu Asp Pro Ala Lys 
        35                  40                  45              


Lys Arg Asn His 
    50          


<210> 99
<211> 52
<212> PRT
<213> Sus scrofa

<400> 99
Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Val Asn Ala Thr Thr 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Leu Gly Pro Glu Glu Asn 
            20                  25                  30          


Ser Thr Ala Val Leu Val Ile Pro Glu Pro Tyr Val Asp Pro Ala Arg 
        35                  40                  45              


Lys Arg Thr His 
    50          


<210> 100
<211> 52
<212> PRT
<213> Equus caballus

<400> 100
Glu Lys Leu Phe Asn Val Thr Ser Thr Leu Arg Ile Asn Ala Thr Ala 
1               5                   10                  15      


Asn Glu Ile Phe Tyr Cys Thr Phe Arg Arg Ser Gly Leu Glu Glu Asn 
            20                  25                  30          


Ser Thr Ala Glu Leu Val Ile Pro Glu Pro Leu Ile Val Pro Ala Asn 
        35                  40                  45              


Lys Arg Thr His 
    50          


