                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> METHODS AND COMPOSITIONS RELATING TO HOMOLOGY-DIRECTED REPAIR

<130> 701039-085691-PCT

<140>
<141>

<150> 62/316,797
<151> 2016-04-01

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 418
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Gly Thr Glu Glu Ala Ile Leu Gly Gly Arg Asp Ser His Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ser Val Leu Cys Phe Gly Gln Cys Gln Tyr Thr 
            20                  25                  30          


Ala Glu Glu Tyr Gln Ala Ile Gln Lys Ala Leu Arg Gln Arg Leu Gly 
        35                  40                  45              


Pro Glu Tyr Ile Ser Ser Arg Met Ala Gly Gly Gly Gln Lys Val Cys 
    50                  55                  60                  


Tyr Ile Glu Gly His Arg Val Ile Asn Leu Ala Asn Glu Met Phe Gly 
65                  70                  75                  80  


Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val Asp Phe Val 
                85                  90                  95      


Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala Phe Val Arg 
            100                 105                 110         


Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly Tyr Gly Val 
        115                 120                 125             


Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys Ala Arg Lys 
    130                 135                 140                 


Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Ser Phe Gly Asn 
145                 150                 155                 160 


Ala Leu Gly Asn Cys Ile Leu Asp Lys Asp Tyr Leu Arg Ser Leu Asn 
                165                 170                 175     


Lys Leu Pro Arg Gln Leu Pro Leu Glu Val Asp Leu Thr Lys Ala Lys 
            180                 185                 190         


Arg Gln Asp Leu Glu Pro Ser Val Glu Glu Ala Arg Tyr Asn Ser Cys 
        195                 200                 205             


Arg Pro Asn Met Ala Leu Gly His Pro Gln Leu Gln Gln Val Thr Ser 
    210                 215                 220                 


Pro Ser Arg Pro Ser His Ala Val Ile Pro Ala Asp Gln Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Ser Leu Ser Ser Ser Ala Val Glu Ser Glu Ala Thr His Gln 
                245                 250                 255     


Arg Lys Leu Arg Gln Lys Gln Leu Gln Gln Gln Phe Arg Glu Arg Met 
            260                 265                 270         


Glu Lys Gln Gln Val Arg Val Ser Thr Pro Ser Ala Glu Lys Ser Glu 
        275                 280                 285             


Ala Ala Pro Pro Ala Pro Pro Val Thr His Ser Thr Pro Val Thr Val 
    290                 295                 300                 


Ser Glu Pro Leu Leu Glu Lys Asp Phe Leu Ala Gly Val Thr Gln Glu 
305                 310                 315                 320 


Leu Ile Lys Thr Leu Glu Asp Asn Ser Glu Lys Trp Ala Val Thr Pro 
                325                 330                 335     


Asp Ala Gly Asp Gly Val Val Lys Pro Ser Ser Arg Ala Asp Pro Ala 
            340                 345                 350         


Gln Thr Ser Asp Thr Leu Ala Leu Asn Asn Gln Met Val Thr Gln Asn 
        355                 360                 365             


Arg Thr Pro His Ser Val Cys His Gln Lys Pro Gln Ala Lys Ser Gly 
    370                 375                 380                 


Ser Trp Asp Leu Gln Thr Tyr Ser Ala Asp Gln Arg Thr Thr Gly Asn 
385                 390                 395                 400 


Trp Glu Ser His Arg Lys Ser Gln Asp Met Lys Lys Arg Lys Tyr Asp 
                405                 410                 415     


Pro Ser 
        


<210> 2
<211> 226
<212> PRT
<213> Homo sapiens

<400> 2
Met Ser Gly Thr Glu Glu Ala Ile Leu Gly Gly Arg Asp Ser His Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ser Val Leu Cys Phe Gly Gln Cys Gln Tyr Thr 
            20                  25                  30          


Ala Glu Glu Tyr Gln Ala Ile Gln Lys Ala Leu Arg Gln Arg Leu Gly 
        35                  40                  45              


Pro Glu Tyr Ile Ser Ser Arg Met Ala Gly Gly Gly Gln Lys Val Cys 
    50                  55                  60                  


Tyr Ile Glu Gly His Arg Val Ile Asn Leu Ala Asn Glu Met Phe Gly 
65                  70                  75                  80  


Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val Asp Phe Val 
                85                  90                  95      


Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala Phe Val Arg 
            100                 105                 110         


Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly Tyr Gly Val 
        115                 120                 125             


Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys Ala Arg Lys 
    130                 135                 140                 


Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Leu Pro Leu Leu 
145                 150                 155                 160 


Gly Val Ser Gly Arg Ile Leu Tyr Ser Leu Phe Ser Val His Ser Val 
                165                 170                 175     


Met Cys Ala Gly Gly Leu Pro Thr Pro Thr Ala Ser Ala Gln Thr Ala 
            180                 185                 190         


Pro Ser Ser Pro Cys Ser Ser Ala Val Leu Arg Tyr Ala Gln Glu Phe 
        195                 200                 205             


Trp Glu Cys Thr Trp Lys Leu Tyr Ser Gly Gln Arg Leu Pro Glu Ile 
    210                 215                 220                 


Thr Lys 
225     


<210> 3
<211> 341
<212> PRT
<213> Homo sapiens

<400> 3
Met Phe Gly Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val 
1               5                   10                  15      


Asp Phe Val Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala 
            20                  25                  30          


Phe Val Arg Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly 
        35                  40                  45              


Tyr Gly Val Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys 
    50                  55                  60                  


Ala Arg Lys Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Ser 
65                  70                  75                  80  


Phe Gly Asn Ala Leu Gly Asn Cys Ile Leu Asp Lys Asp Tyr Leu Arg 
                85                  90                  95      


Ser Leu Asn Lys Leu Pro Arg Gln Leu Pro Leu Glu Val Asp Leu Thr 
            100                 105                 110         


Lys Ala Lys Arg Gln Asp Leu Glu Pro Ser Val Glu Glu Ala Arg Tyr 
        115                 120                 125             


Asn Ser Cys Arg Pro Asn Met Ala Leu Gly His Pro Gln Leu Gln Gln 
    130                 135                 140                 


Val Thr Ser Pro Ser Arg Pro Ser His Ala Val Ile Pro Ala Asp Gln 
145                 150                 155                 160 


Asp Cys Ser Ser Arg Ser Leu Ser Ser Ser Ala Val Glu Ser Glu Ala 
                165                 170                 175     


Thr His Gln Arg Lys Leu Arg Gln Lys Gln Leu Gln Gln Gln Phe Arg 
            180                 185                 190         


Glu Arg Met Glu Lys Gln Gln Val Arg Val Ser Thr Pro Ser Ala Glu 
        195                 200                 205             


Lys Ser Glu Ala Ala Pro Pro Ala Pro Pro Val Thr His Ser Thr Pro 
    210                 215                 220                 


Val Thr Val Ser Glu Pro Leu Leu Glu Lys Asp Phe Leu Ala Gly Val 
225                 230                 235                 240 


Thr Gln Glu Leu Ile Lys Thr Leu Glu Asp Asn Ser Glu Lys Trp Ala 
                245                 250                 255     


Val Thr Pro Asp Ala Gly Asp Gly Val Val Lys Pro Ser Ser Arg Ala 
            260                 265                 270         


Asp Pro Ala Gln Thr Ser Asp Thr Leu Ala Leu Asn Asn Gln Met Val 
        275                 280                 285             


Thr Gln Asn Arg Thr Pro His Ser Val Cys His Gln Lys Pro Gln Ala 
    290                 295                 300                 


Lys Ser Gly Ser Trp Asp Leu Gln Thr Tyr Ser Ala Asp Gln Arg Thr 
305                 310                 315                 320 


Thr Gly Asn Trp Glu Ser His Arg Lys Ser Gln Asp Met Lys Lys Arg 
                325                 330                 335     


Lys Tyr Asp Pro Ser 
            340     


<210> 4
<211> 301
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Gly Thr Glu Glu Ala Ile Leu Gly Gly Arg Asp Ser His Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ser Val Leu Cys Phe Gly Gln Cys Gln Tyr Thr 
            20                  25                  30          


Ala Glu Glu Tyr Gln Ala Ile Gln Lys Ala Leu Arg Gln Arg Leu Gly 
        35                  40                  45              


Pro Glu Tyr Ile Ser Ser Arg Met Ala Gly Gly Gly Gln Lys Val Cys 
    50                  55                  60                  


Tyr Ile Glu Gly His Arg Val Ile Asn Leu Ala Asn Glu Met Phe Gly 
65                  70                  75                  80  


Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val Asp Phe Val 
                85                  90                  95      


Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala Phe Val Arg 
            100                 105                 110         


Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly Tyr Gly Val 
        115                 120                 125             


Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys Ala Arg Lys 
    130                 135                 140                 


Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Ser Phe Gly Asn 
145                 150                 155                 160 


Ala Leu Gly Asn Cys Ile Leu Asp Lys Asp Tyr Leu Arg Ser Leu Asn 
                165                 170                 175     


Lys Leu Pro Arg Gln Leu Pro Leu Glu Val Asp Leu Thr Lys Ala Lys 
            180                 185                 190         


Arg Gln Asp Leu Glu Pro Ser Val Glu Glu Ala Arg Tyr Asn Ser Cys 
        195                 200                 205             


Arg Pro Asn Met Ala Leu Gly His Pro Gln Leu Gln Gln Val Thr Ser 
    210                 215                 220                 


Pro Ser Arg Pro Ser His Ala Val Ile Pro Ala Asp Gln Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Ser Arg Gly Cys Cys Ser Gly Ala Arg Pro Arg Arg Arg Pro 
                245                 250                 255     


Leu Met Gln Lys Pro Glu Leu Ile Arg Arg Gly Glu Arg Gly His Ala 
            260                 265                 270         


Pro Ala Glu Ala Pro Ala Glu Ala Ala Ala Ala Ala Val Pro Gly Ala 
        275                 280                 285             


Asp Gly Glu Ala Ala Gly Ser Ser Leu His Ala Val Ser 
    290                 295                 300     


<210> 5
<211> 340
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ser Arg Ser 
65                  70                  75                  80  


Val Ala Arg Leu Glu Cys Asn Ser Val Ile Leu Val Tyr Cys Thr Leu 
                85                  90                  95      


Arg Leu Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Val 
            100                 105                 110         


Gly Thr Thr Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
        115                 120                 125             


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
    130                 135                 140                 


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
145                 150                 155                 160 


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
                165                 170                 175     


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
            180                 185                 190         


Ala Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
        195                 200                 205             


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
    210                 215                 220                 


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
225                 230                 235                 240 


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
                245                 250                 255     


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
            260                 265                 270         


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
305                 310                 315                 320 


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
                325                 330                 335     


Asp Ala Lys Asp 
            340 


<210> 6
<211> 339
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210> 7
<211> 280
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Ile Val Ser Glu Glu Arg Lys Arg Gly Asn Gln Asn Leu Gln 
            260                 265                 270         


Asn Leu Arg Leu Ser Leu Ser Ser 
        275                 280 


<210> 8
<211> 340
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Thr Glu Ser Arg Ser 
65                  70                  75                  80  


Val Ala Arg Leu Glu Cys Asn Ser Val Ile Leu Val Tyr Cys Thr Leu 
                85                  90                  95      


Arg Leu Ser Gly Ser Ser Asp Ser Pro Ala Ser Ala Ser Arg Val Val 
            100                 105                 110         


Gly Thr Thr Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly 
        115                 120                 125             


Glu Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr 
    130                 135                 140                 


Cys Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr 
145                 150                 155                 160 


Ile Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala 
                165                 170                 175     


Glu Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr 
            180                 185                 190         


Ala Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala 
        195                 200                 205             


Ser Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser 
    210                 215                 220                 


Ala Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser 
225                 230                 235                 240 


Ala Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu 
                245                 250                 255     


Ala Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala 
            260                 265                 270         


Gln Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile 
        275                 280                 285             


Gly Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg 
    290                 295                 300                 


Lys Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys 
305                 310                 315                 320 


Leu Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly 
                325                 330                 335     


Asp Ala Lys Asp 
            340 


<210> 9
<211> 1417
<212> PRT
<213> Homo sapiens

<400> 9
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210> 10
<211> 1286
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Glu  Ser Leu Ser Ser Asp  Pro Glu Val 
    1115                 1120                 1125             


Leu Leu  Gln Ile Asp Gly Val  Thr Glu Asp Lys Leu  Glu Lys Tyr 
    1130                 1135                 1140             


Gly Ala  Glu Val Ile Ser Val  Leu Gln Lys Tyr Ser  Glu Trp Thr 
    1145                 1150                 1155             


Ser Pro  Ala Glu Asp Ser Ser  Pro Gly Ile Ser Leu  Ser Ser Ser 
    1160                 1165                 1170             


Arg Gly  Pro Gly Arg Ser Ala  Ala Glu Glu Leu Asp  Glu Glu Ile 
    1175                 1180                 1185             


Pro Val  Ser Ser His Tyr Phe  Ala Ser Lys Thr Arg  Asn Glu Arg 
    1190                 1195                 1200             


Lys Arg  Lys Lys Met Pro Ala  Ser Gln Arg Ser Lys  Arg Arg Lys 
    1205                 1210                 1215             


Thr Ala  Ser Ser Gly Ser Lys  Ala Lys Gly Gly Ser  Ala Thr Cys 
    1220                 1225                 1230             


Arg Lys  Ile Ser Ser Lys Thr  Lys Ser Ser Ser Ile  Ile Gly Ser 
    1235                 1240                 1245             


Ser Ser  Ala Ser His Thr Ser  Gln Ala Thr Ser Gly  Ala Asn Ser 
    1250                 1255                 1260             


Lys Leu  Gly Ile Met Ala Pro  Pro Lys Pro Ile Asn  Arg Pro Phe 
    1265                 1270                 1275             


Leu Lys  Pro Ser Tyr Ala Phe  Ser 
    1280                 1285     


<210> 11
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 11
Met Glu His Ile Cys Lys Leu Ile Asp Thr Ile Pro Asp Asp Lys Leu 
1               5                   10                  15      


Lys Leu Leu Asp Cys Gly Asn Glu Leu Leu Gln Gln Arg Asn Ile Arg 
            20                  25                  30          


Arg Lys Leu Leu Thr Glu Val Asp Phe Asn Lys Ser Asp Ala Ser Leu 
        35                  40                  45              


Leu Gly Ser Leu Trp Arg Tyr Arg Pro Asp Ser Leu Asp Gly Pro Met 
    50                  55                  60                  


Glu Gly Asp Ser Cys Pro Thr Gly Asn Ser Met Lys Glu Leu Asn Phe 
65                  70                  75                  80  


Ser His Leu Pro Ser Asn Ser Val Ser Pro Gly Asp Cys Leu Leu Thr 
                85                  90                  95      


Thr Thr Leu Gly Lys Thr Gly Phe Ser Ala Thr Arg Lys Asn Leu Phe 
            100                 105                 110         


Glu Arg Pro Leu Phe Asn Thr His Leu Gln Lys Ser Phe Val Ser Ser 
        115                 120                 125             


Asn Trp Ala Glu Thr Pro Arg Leu Gly Lys Lys Asn Glu Ser Ser Tyr 
    130                 135                 140                 


Phe Pro Gly Asn Val Leu Thr Ser Thr Ala Val Lys Asp Gln Asn Lys 
145                 150                 155                 160 


His Thr Ala Ser Ile Asn Asp Leu Glu Arg Glu Thr Gln Pro Ser Tyr 
                165                 170                 175     


Asp Ile Asp Asn Phe Asp Ile Asp Asp Phe Asp Asp Asp Asp Asp Trp 
            180                 185                 190         


Glu Asp Ile Met His Asn Leu Ala Ala Ser Lys Ser Ser Thr Ala Ala 
        195                 200                 205             


Tyr Gln Pro Ile Lys Glu Gly Arg Pro Ile Lys Ser Val Ser Glu Arg 
    210                 215                 220                 


Leu Ser Ser Ala Lys Thr Asp Cys Leu Pro Val Ser Ser Thr Ala Gln 
225                 230                 235                 240 


Asn Ile Asn Phe Ser Glu Ser Ile Gln Asn Tyr Thr Asp Lys Ser Ala 
                245                 250                 255     


Gln Asn Leu Ala Ser Arg Asn Leu Lys His Glu Arg Phe Gln Ser Leu 
            260                 265                 270         


Ser Phe Pro His Thr Lys Glu Met Met Lys Ile Phe His Lys Lys Phe 
        275                 280                 285             


Gly Leu His Asn Phe Arg Thr Asn Gln Leu Glu Ala Ile Asn Ala Ala 
    290                 295                 300                 


Leu Leu Gly Glu Asp Cys Phe Ile Leu Met Pro Thr Gly Gly Gly Lys 
305                 310                 315                 320 


Ser Leu Cys Tyr Gln Leu Pro Ala Cys Val Ser Pro Gly Val Thr Val 
                325                 330                 335     


Val Ile Ser Pro Leu Arg Ser Leu Ile Val Asp Gln Val Gln Lys Leu 
            340                 345                 350         


Thr Ser Leu Asp Ile Pro Ala Thr Tyr Leu Thr Gly Asp Lys Thr Asp 
        355                 360                 365             


Ser Glu Ala Thr Asn Ile Tyr Leu Gln Leu Ser Lys Lys Asp Pro Ile 
    370                 375                 380                 


Ile Lys Leu Leu Tyr Val Thr Pro Glu Lys Ile Cys Ala Ser Asn Arg 
385                 390                 395                 400 


Leu Ile Ser Thr Leu Glu Asn Leu Tyr Glu Arg Lys Leu Leu Ala Arg 
                405                 410                 415     


Phe Val Ile Asp Glu Ala His Cys Val Ser Gln Trp Gly His Asp Phe 
            420                 425                 430         


Arg Gln Asp Tyr Lys Arg Met Asn Met Leu Arg Gln Lys Phe Pro Ser 
        435                 440                 445             


Val Pro Val Met Ala Leu Thr Ala Thr Ala Asn Pro Arg Val Gln Lys 
    450                 455                 460                 


Asp Ile Leu Thr Gln Leu Lys Ile Leu Arg Pro Gln Val Phe Ser Met 
465                 470                 475                 480 


Ser Phe Asn Arg His Asn Leu Lys Tyr Tyr Val Leu Pro Lys Lys Pro 
                485                 490                 495     


Lys Lys Val Ala Phe Asp Cys Leu Glu Trp Ile Arg Lys His His Pro 
            500                 505                 510         


Tyr Asp Ser Gly Ile Ile Tyr Cys Leu Ser Arg Arg Glu Cys Asp Thr 
        515                 520                 525             


Met Ala Asp Thr Leu Gln Arg Asp Gly Leu Ala Ala Leu Ala Tyr His 
    530                 535                 540                 


Ala Gly Leu Ser Asp Ser Ala Arg Asp Glu Val Gln Gln Lys Trp Ile 
545                 550                 555                 560 


Asn Gln Asp Gly Cys Gln Val Ile Cys Ala Thr Ile Ala Phe Gly Met 
                565                 570                 575     


Gly Ile Asp Lys Pro Asp Val Arg Phe Val Ile His Ala Ser Leu Pro 
            580                 585                 590         


Lys Ser Val Glu Gly Tyr Tyr Gln Glu Ser Gly Arg Ala Gly Arg Asp 
        595                 600                 605             


Gly Glu Ile Ser His Cys Leu Leu Phe Tyr Thr Tyr His Asp Val Thr 
    610                 615                 620                 


Arg Leu Lys Arg Leu Ile Met Met Glu Lys Asp Gly Asn His His Thr 
625                 630                 635                 640 


Arg Glu Thr His Phe Asn Asn Leu Tyr Ser Met Val His Tyr Cys Glu 
                645                 650                 655     


Asn Ile Thr Glu Cys Arg Arg Ile Gln Leu Leu Ala Tyr Phe Gly Glu 
            660                 665                 670         


Asn Gly Phe Asn Pro Asp Phe Cys Lys Lys His Pro Asp Val Ser Cys 
        675                 680                 685             


Asp Asn Cys Cys Lys Thr Lys Asp Tyr Lys Thr Arg Asp Val Thr Asp 
    690                 695                 700                 


Asp Val Lys Ser Ile Val Arg Phe Val Gln Glu His Ser Ser Ser Gln 
705                 710                 715                 720 


Gly Met Arg Asn Ile Lys His Val Gly Pro Ser Gly Arg Phe Thr Met 
                725                 730                 735     


Asn Met Leu Val Asp Ile Phe Leu Gly Ser Lys Ser Ala Lys Ile Gln 
            740                 745                 750         


Ser Gly Ile Phe Gly Lys Gly Ser Ala Tyr Ser Arg His Asn Ala Glu 
        755                 760                 765             


Arg Leu Phe Lys Lys Leu Ile Leu Asp Lys Ile Leu Asp Glu Asp Leu 
    770                 775                 780                 


Tyr Ile Asn Ala Asn Asp Gln Ala Ile Ala Tyr Val Met Leu Gly Asn 
785                 790                 795                 800 


Lys Ala Gln Thr Val Leu Asn Gly Asn Leu Lys Val Asp Phe Met Glu 
                805                 810                 815     


Thr Glu Asn Ser Ser Ser Val Lys Lys Gln Lys Ala Leu Val Ala Lys 
            820                 825                 830         


Val Ser Gln Arg Glu Glu Met Val Lys Lys Cys Leu Gly Glu Leu Thr 
        835                 840                 845             


Glu Val Cys Lys Ser Leu Gly Lys Val Phe Gly Val His Tyr Phe Asn 
    850                 855                 860                 


Ile Phe Asn Thr Val Thr Leu Lys Lys Leu Ala Glu Ser Leu Ser Ser 
865                 870                 875                 880 


Asp Pro Glu Val Leu Leu Gln Ile Asp Gly Val Thr Glu Asp Lys Leu 
                885                 890                 895     


Glu Lys Tyr Gly Ala Glu Val Ile Ser Val Leu Gln Lys Tyr Ser Glu 
            900                 905                 910         


Trp Thr Ser Pro Ala Glu Asp Ser Ser Pro Gly Ile Ser Leu Ser Ser 
        915                 920                 925             


Ser Arg Gly Pro Gly Arg Ser Ala Ala Glu Glu Leu Asp Glu Glu Ile 
    930                 935                 940                 


Pro Val Ser Ser His Tyr Phe Ala Ser Lys Thr Arg Asn Glu Arg Lys 
945                 950                 955                 960 


Arg Lys Lys Met Pro Ala Ser Gln Arg Ser Lys Arg Arg Lys Thr Ala 
                965                 970                 975     


Ser Ser Gly Ser Lys Ala Lys Gly Gly Ser Ala Thr Cys Arg Lys Ile 
            980                 985                 990         


Ser Ser Lys Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
        995                 1000                 1005             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1010                 1015                 1020             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1025                 1030                 1035             


Tyr Ala  Phe Ser 
    1040         


<210> 12
<211> 1977
<212> PRT
<213> Homo sapiens

<400> 12
Met Pro Gly Glu Gln Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp 
1               5                   10                  15      


Phe Ser Gln Gln Asp Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro 
            20                  25                  30          


Glu Ser Gln Val Leu Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu 
        35                  40                  45              


Ser Arg His Leu Pro Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu 
    50                  55                  60                  


Asp Val Val Ser Asn Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp 
65                  70                  75                  80  


Gly Asn Ser Gly Phe Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp 
                85                  90                  95      


Pro Val Asp Ser Ser Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val 
            100                 105                 110         


Ile Glu Gln Leu Pro Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met 
        115                 120                 125             


Ser Val Glu Ser Ala Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu 
    130                 135                 140                 


Glu Gln Lys Glu Lys Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr 
145                 150                 155                 160 


His Ser Leu Gly Ala Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly 
                165                 170                 175     


Val Leu Glu Leu Ser Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro 
            180                 185                 190         


Tyr Glu Val Asp Lys Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly 
        195                 200                 205             


Tyr Thr Arg Leu Ser Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu 
    210                 215                 220                 


Glu Gln Ser Asn Glu Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp 
225                 230                 235                 240 


Ile Pro Val Thr Ala Gln Pro Ser Lys Asp Val His Val Val Lys Glu 
                245                 250                 255     


Gln Asn Pro Pro Pro Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys 
            260                 265                 270         


Ala Ser Val Ala Ala Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu 
        275                 280                 285             


Leu Met Glu Ser Gly Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val 
    290                 295                 300                 


Leu Ser Thr Gln Glu Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser 
305                 310                 315                 320 


Ser Asp Gly Cys Ser Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu 
                325                 330                 335     


Ala Ser Thr Pro Ala Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln 
            340                 345                 350         


Arg Ser Leu Val Gln Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val 
        355                 360                 365             


Ala Pro Ser Pro Asp Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser 
    370                 375                 380                 


Ser Pro Thr Glu Gln Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser 
385                 390                 395                 400 


Val Leu Ser Glu Glu Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser 
                405                 410                 415     


Gly Glu Pro Val Glu Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr 
            420                 425                 430         


Val Ser Pro Gln Ala Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe 
        435                 440                 445             


Pro Pro Gly Ser Leu Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp 
    450                 455                 460                 


Ile Phe Ile Pro Ser Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys 
465                 470                 475                 480 


Lys Asp Gly Asp Met His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys 
                485                 490                 495     


Thr Ser Glu Ile Glu Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser 
            500                 505                 510         


Leu Thr Gly Asp Ser Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser 
        515                 520                 525             


Gln Ser Pro Lys Met Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp 
    530                 535                 540                 


Gly Glu Asn Thr Gln Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu 
545                 550                 555                 560 


Asn Ser Lys Phe Val Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro 
                565                 570                 575     


Ala Gln Asp Gly Glu Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys 
            580                 585                 590         


Gly Asp Asp Thr Asp Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly 
        595                 600                 605             


Cys Lys Gly Arg Glu Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu 
    610                 615                 620                 


Thr Cys Asp Ser Gly Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser 
625                 630                 635                 640 


Glu Ala Leu Ser Ser Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys 
                645                 650                 655     


Glu His His Pro Glu Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile 
            660                 665                 670         


Pro Glu Thr Pro Cys Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn 
        675                 680                 685             


Met Glu Ser Val Pro Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln 
    690                 695                 700                 


Gly Leu Cys Leu Gln Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala 
705                 710                 715                 720 


Met Glu Val Glu Thr Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu 
                725                 730                 735     


Ala Ile Leu Asp Gln Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu 
            740                 745                 750         


Glu Ala Thr Ser Glu Asp Ser Ser Val Val Ile Val Asp Val Lys Glu 
        755                 760                 765             


Pro Ser Pro Arg Val Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu 
    770                 775                 780                 


Lys Cys Ser Asp Ser Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu 
785                 790                 795                 800 


Pro Cys Ala Glu Asn Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu 
                805                 810                 815     


Tyr Glu Gly Asp Leu Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu 
            820                 825                 830         


Gln Asp Ser Ser Gln Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro 
        835                 840                 845             


Leu Arg Leu Asp Gln Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr 
    850                 855                 860                 


Ser Asn Ser Leu Thr Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu 
865                 870                 875                 880 


Ser Ser Asp Ala Glu Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala 
                885                 890                 895     


Ser Gln Ser Phe Cys Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr 
            900                 905                 910         


Leu Pro Lys Glu Gly Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro 
        915                 920                 925             


Pro Leu Ile Gly His Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro 
    930                 935                 940                 


Ile Gly Ile Ser Asn Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val 
945                 950                 955                 960 


Met Ser Glu Ser Met Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly 
                965                 970                 975     


Lys Gly Asp Ser Gly Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu 
            980                 985                 990         


Arg Met Lys Leu Val Ser Pro Glu  Thr Glu Ala Ser Glu  Glu Ser Leu 
        995                 1000                 1005             


Gln Phe  Asn Leu Glu Lys Pro  Ala Thr Gly Glu Arg  Lys Asn Gly 
    1010                 1015                 1020             


Ser Thr  Ala Val Ala Glu Ser  Val Ala Ser Pro Gln  Lys Thr Met 
    1025                 1030                 1035             


Ser Val  Leu Ser Cys Ile Cys  Glu Ala Arg Gln Glu  Asn Glu Ala 
    1040                 1045                 1050             


Arg Ser  Glu Asp Pro Pro Thr  Thr Pro Ile Arg Gly  Asn Leu Leu 
    1055                 1060                 1065             


His Phe  Pro Ser Ser Gln Gly  Glu Glu Glu Lys Glu  Lys Leu Glu 
    1070                 1075                 1080             


Gly Asp  His Thr Ile Arg Gln  Ser Gln Gln Pro Met  Lys Pro Ile 
    1085                 1090                 1095             


Ser Pro  Val Lys Asp Pro Val  Ser Pro Ala Ser Gln  Lys Met Val 
    1100                 1105                 1110             


Ile Gln  Gly Pro Ser Ser Pro  Gln Gly Glu Ala Met  Val Thr Asp 
    1115                 1120                 1125             


Val Leu  Glu Asp Gln Lys Glu  Gly Arg Ser Thr Asn  Lys Glu Asn 
    1130                 1135                 1140             


Pro Ser  Lys Ala Leu Ile Glu  Arg Pro Ser Gln Asn  Asn Ile Gly 
    1145                 1150                 1155             


Ile Gln  Thr Met Glu Cys Ser  Leu Arg Val Pro Glu  Thr Val Ser 
    1160                 1165                 1170             


Ala Ala  Thr Gln Thr Ile Lys  Asn Val Cys Glu Gln  Gly Thr Ser 
    1175                 1180                 1185             


Thr Val  Asp Gln Asn Phe Gly  Lys Gln Asp Ala Thr  Val Gln Thr 
    1190                 1195                 1200             


Glu Arg  Gly Ser Gly Glu Lys  Pro Val Ser Ala Pro  Gly Asp Asp 
    1205                 1210                 1215             


Thr Glu  Ser Leu His Ser Gln  Gly Glu Glu Glu Phe  Asp Met Pro 
    1220                 1225                 1230             


Gln Pro  Pro His Gly His Val  Leu His Arg His Met  Arg Thr Ile 
    1235                 1240                 1245             


Arg Glu  Val Arg Thr Leu Val  Thr Arg Val Ile Thr  Asp Val Tyr 
    1250                 1255                 1260             


Tyr Val  Asp Gly Thr Glu Val  Glu Arg Lys Val Thr  Glu Glu Thr 
    1265                 1270                 1275             


Glu Glu  Pro Ile Val Glu Cys  Gln Glu Cys Glu Thr  Glu Val Ser 
    1280                 1285                 1290             


Pro Ser  Gln Thr Gly Gly Ser  Ser Gly Asp Leu Gly  Asp Ile Ser 
    1295                 1300                 1305             


Ser Phe  Ser Ser Lys Ala Ser  Ser Leu His Arg Thr  Ser Ser Gly 
    1310                 1315                 1320             


Thr Ser  Leu Ser Ala Met His  Ser Ser Gly Ser Ser  Gly Lys Gly 
    1325                 1330                 1335             


Ala Gly  Pro Leu Arg Gly Lys  Thr Ser Gly Thr Glu  Pro Ala Asp 
    1340                 1345                 1350             


Phe Ala  Leu Pro Ser Ser Arg  Gly Gly Pro Gly Lys  Leu Ser Pro 
    1355                 1360                 1365             


Arg Lys  Gly Val Ser Gln Thr  Gly Thr Pro Val Cys  Glu Glu Asp 
    1370                 1375                 1380             


Gly Asp  Ala Gly Leu Gly Ile  Arg Gln Gly Gly Lys  Ala Pro Val 
    1385                 1390                 1395             


Thr Pro  Arg Gly Arg Gly Arg  Arg Gly Arg Pro Pro  Ser Arg Thr 
    1400                 1405                 1410             


Thr Gly  Thr Arg Glu Thr Ala  Val Pro Gly Pro Leu  Gly Ile Glu 
    1415                 1420                 1425             


Asp Ile  Ser Pro Asn Leu Ser  Pro Asp Asp Lys Ser  Phe Ser Arg 
    1430                 1435                 1440             


Val Val  Pro Arg Val Pro Asp  Ser Thr Arg Arg Thr  Asp Val Gly 
    1445                 1450                 1455             


Ala Gly  Ala Leu Arg Arg Ser  Asp Ser Pro Glu Ile  Pro Phe Gln 
    1460                 1465                 1470             


Ala Ala  Ala Gly Pro Ser Asp  Gly Leu Asp Ala Ser  Ser Pro Gly 
    1475                 1480                 1485             


Asn Ser  Phe Val Gly Leu Arg  Val Val Ala Lys Trp  Ser Ser Asn 
    1490                 1495                 1500             


Gly Tyr  Phe Tyr Ser Gly Lys  Ile Thr Arg Asp Val  Gly Ala Gly 
    1505                 1510                 1515             


Lys Tyr  Lys Leu Leu Phe Asp  Asp Gly Tyr Glu Cys  Asp Val Leu 
    1520                 1525                 1530             


Gly Lys  Asp Ile Leu Leu Cys  Asp Pro Ile Pro Leu  Asp Thr Glu 
    1535                 1540                 1545             


Val Thr  Ala Leu Ser Glu Asp  Glu Tyr Phe Ser Ala  Gly Val Val 
    1550                 1555                 1560             


Lys Gly  His Arg Lys Glu Ser  Gly Glu Leu Tyr Tyr  Ser Ile Glu 
    1565                 1570                 1575             


Lys Glu  Gly Gln Arg Lys Trp  Tyr Lys Arg Met Ala  Val Ile Leu 
    1580                 1585                 1590             


Ser Leu  Glu Gln Gly Asn Arg  Leu Arg Glu Gln Tyr  Gly Leu Gly 
    1595                 1600                 1605             


Pro Tyr  Glu Ala Val Thr Pro  Leu Thr Lys Ala Ala  Asp Ile Ser 
    1610                 1615                 1620             


Leu Asp  Asn Leu Val Glu Gly  Lys Arg Lys Arg Arg  Ser Asn Val 
    1625                 1630                 1635             


Ser Ser  Pro Ala Thr Pro Thr  Ala Ser Ser Ser Ser  Ser Thr Thr 
    1640                 1645                 1650             


Pro Thr  Arg Lys Ile Thr Glu  Ser Pro Arg Ala Ser  Met Gly Val 
    1655                 1660                 1665             


Leu Ser  Gly Lys Arg Lys Leu  Ile Thr Ser Glu Glu  Glu Arg Ser 
    1670                 1675                 1680             


Pro Ala  Lys Arg Gly Arg Lys  Ser Ala Thr Val Lys  Pro Gly Ala 
    1685                 1690                 1695             


Val Gly  Ala Gly Glu Phe Val  Ser Pro Cys Glu Ser  Gly Asp Asn 
    1700                 1705                 1710             


Thr Gly  Glu Pro Ser Ala Leu  Glu Glu Gln Arg Gly  Pro Leu Pro 
    1715                 1720                 1725             


Leu Asn  Lys Thr Leu Phe Leu  Gly Tyr Ala Phe Leu  Leu Thr Met 
    1730                 1735                 1740             


Ala Thr  Thr Ser Asp Lys Leu  Ala Ser Arg Ser Lys  Leu Pro Asp 
    1745                 1750                 1755             


Gly Pro  Thr Gly Ser Ser Glu  Glu Glu Glu Glu Phe  Leu Glu Ile 
    1760                 1765                 1770             


Pro Pro  Phe Asn Lys Gln Tyr  Thr Glu Ser Gln Leu  Arg Ala Gly 
    1775                 1780                 1785             


Ala Gly  Tyr Ile Leu Glu Asp  Phe Asn Glu Ala Gln  Cys Asn Thr 
    1790                 1795                 1800             


Ala Tyr  Gln Cys Leu Leu Ile  Ala Asp Gln His Cys  Arg Thr Arg 
    1805                 1810                 1815             


Lys Tyr  Phe Leu Cys Leu Ala  Ser Gly Ile Pro Cys  Val Ser His 
    1820                 1825                 1830             


Val Trp  Val His Asp Ser Cys  His Ala Asn Gln Leu  Gln Asn Tyr 
    1835                 1840                 1845             


Arg Asn  Tyr Leu Leu Pro Ala  Gly Tyr Ser Leu Glu  Glu Gln Arg 
    1850                 1855                 1860             


Ile Leu  Asp Trp Gln Pro Arg  Glu Asn Pro Phe Gln  Asn Leu Lys 
    1865                 1870                 1875             


Val Leu  Leu Val Ser Asp Gln  Gln Gln Asn Phe Leu  Glu Leu Trp 
    1880                 1885                 1890             


Ser Glu  Ile Leu Met Thr Gly  Gly Ala Ala Ser Val  Lys Gln His 
    1895                 1900                 1905             


His Ser  Ser Ala His Asn Lys  Asp Ile Ala Leu Gly  Val Phe Asp 
    1910                 1915                 1920             


Val Val  Val Thr Asp Pro Ser  Cys Pro Ala Ser Val  Leu Lys Cys 
    1925                 1930                 1935             


Ala Glu  Ala Leu Gln Leu Pro  Val Val Ser Gln Glu  Trp Val Ile 
    1940                 1945                 1950             


Gln Cys  Leu Ile Val Gly Glu  Arg Ile Gly Phe Lys  Gln His Pro 
    1955                 1960                 1965             


Lys Tyr  Lys His Asp Tyr Val  Ser His 
    1970                 1975         


<210> 13
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Homing endonuclease
      peptide

<400> 13
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
gggccactag ggacaggat                                                    19


<210> 15
<211> 184
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
tgaagcagca cgacttcttc aagtccgcca tgcccgaagg ctacgtccag gagcgcacca       60

tcttcttcaa ggacgacggc aactacaaga cccgcgccga ggtgaagttc gagggcgaca      120

ccctggtgaa ccgcatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg      180

ggca                                                                   184


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
aattatggag tatgtgtctg                                                   20


<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
acgttgatgg cagttgcagg tc                                                22


<210> 18
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
ctgacagagt tgctagacac tgggttg                                           27


<210> 19
<211> 184
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
ttccttagtc tttctttgaa gcagcaagta tgatgagcaa gctttctcac aagcatttgg       60

ttttaaatta tggagtatgt gtgtttaaac ctgtggagac gagagtaagt aaaactacag      120

gctttctaat gcctttctca gagcatctgt ttttgtttat atagaaaatt cagtttcagg      180

atca                                                                   184


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
gtcacctcca atgactaggg                                                   20


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
gtcttcccat caggctctca gctc                                              24


<210> 22
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gagctggagg tagagaccag ggt                                               23


<210> 23
<211> 184
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
aagaagggct cccatcacat caaccggtgg cgcattgcca cgaagcaggc caatggggag       60

gacatcgatg tcacctccaa tgactagttt aaacgggtgg gcaaccacaa acccacgagg      120

gcagagtgct gcttgctgct ggccaggccc ctgcgtgggc ccaagctgga ctctggccac      180

tccc                                                                   184


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
agtctgccgt tactgccctg                                                   20


<210> 25
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
tgccagaaga gccaaggaca ggta                                              24


<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
catcaagcgt cccatagact cacc                                              24


<210> 27
<211> 188
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atttgcttct gacacaactg tgttcactag caacctcaaa cagacaccat ggtgcatctg       60

actcctgagg agaagtctgc cgttactgcc gtttaaacct gtggggcaag gtgaacgtgg      120

atgaagttgg tggtgaggcc ctgggcaggt tggtatcaag gttacaagac aggtttaagg      180

agaccaat                                                               188


<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
tcactatgct gccgcccagt                                                   20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
ctgcaaaagg ctgaagagca                                                   20


<210> 30
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ccccaagatg actatcttta atgtc                                             25


<210> 31
<211> 184
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
catgactgac atctacctgc tcaacctggc catctctgac ctgtttttcc ttcttactgt       60

ccccttctgg gctcactatg ctgccgccgt ttaaaccagt gggactttgg aaatacaatg      120

tgtcaactct tgacagggct ctattttata ggcttcttct ctggaatctt cttcatcatc      180

ctcc                                                                   184


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
gctgtgtttg cgtctctccc                                                   20


<210> 33
<211> 192
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
gtccatgctg tgtttgcttt aaaagccagg acggtcacct ttggggtggt gacaagtgtg       60

atcacttggg tggtggctgt gtttgcgtct ctgtttaaac cccaggaatc atctttacca      120

gatctcaaaa agaaggtctt cattacacct gcagctctca ttttccatac agtcagtatc      180

aattctggaa ga                                                          192


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
gctactctct ctttctggcc                                                   20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
tgatcttggc tactatacca                                                   20


<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
gagctgcaag cctgttatgt g                                                 21


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
cgcaacccag taccacttac                                                   20


<210> 38
<211> 184
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 38
gaattggggc tcatcaatta tcaattcttt cacccttcaa ataattcttt tctttattca       60

atgcctgtag ctattgcatt aatgaccaca gcggtcatct ctacctgcga ccatggtata      120

gtagccaaga tcaagagagt gatcatggag agagacactt accctcggaa gtggggttta      180

ggtc                                                                   184


<210> 39
<211> 51
<212> DNA
<213> Homo sapiens

<400> 39
ccacagcggt catctctacc tgcgaccatg gtatagtagc caagatcaag a                51


<210> 40
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ccacagtggt catctctacc tgcgaccatg gtatagtagc caagatcaag a                51


<210> 41
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
ccacagcggt catctctacc tgcgatcatg gtatagtagc caagatcaag a                51


<210> 42
<211> 23
<212> DNA
<213> Homo sapiens

<400> 42
tcactatgct gccgcccagt ggg                                               23


<210> 43
<211> 23
<212> DNA
<213> Homo sapiens

<400> 43
gctgtgtttg cgtctctccc agg                                               23


<210> 44
<211> 23
<212> DNA
<213> Homo sapiens

<400> 44
gctgtgtccg cgcctctccc cgg                                               23


<210> 45
<211> 23
<212> DNA
<213> Homo sapiens

<400> 45
gctgtgtttg cgcctttccc agg                                               23


<210> 46
<211> 23
<212> DNA
<213> Homo sapiens

<400> 46
gctgtgtttg tgcctccccc agg                                               23


<210> 47
<211> 23
<212> DNA
<213> Homo sapiens

<400> 47
gctgtgctag cacctccccc agg                                               23


<210> 48
<211> 23
<212> DNA
<213> Homo sapiens

<400> 48
gctgtgtgct cgtctctccc tgg                                               23


<210> 49
<211> 23
<212> DNA
<213> Homo sapiens

<400> 49
tgggtgtctg cagctctccc agg                                               23


<210> 50
<211> 23
<212> DNA
<213> Homo sapiens

<400> 50
cacgagtgtg cgcctccccc agg                                               23


