﻿               SEQUENCE LISTING

<110> IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH

<120> Combination of an apelin antagonist and an angiogenesis inhibitor for the treatment of cancer

<130> R70739

<150> EP 16164235.0
<151> 07.04.2016

<160> 23

<170> BiSSAP 1.3

<210> 1
<211> 77
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin-77

<400> 1
Met Asn Leu Arg Leu Cys Val Gln Ala Leu Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      
Leu Thr Ala Val Cys Gly Gly Ser Leu Met Pro Leu Pro Asp Gly Asn 
            20                  25                  30          
Gly Leu Glu Asp Gly Asn Val Arg His Leu Val Gln Pro Arg Gly Ser 
        35                  40                  45              
Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg 
    50                  55                  60                  
Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
65                  70                  75          

<210> 2
<211> 55
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin-55

<400> 2
Gly Ser Leu Met Pro Leu Pro Asp Gly Asn Gly Leu Glu Asp Gly Asn 
1               5                   10                  15      
Val Arg His Leu Val Gln Pro Arg Gly Ser Arg Asn Gly Pro Gly Pro 
            20                  25                  30          
Trp Gln Gly Gly Arg Arg Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser 
        35                  40                  45              
His Lys Gly Pro Met Pro Phe 
    50                  55  

<210> 3
<211> 36
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin-36

<400> 3
Leu Val Gln Pro Arg Gly Ser Arg Asn Gly Pro Gly Pro Trp Gln Gly 
1               5                   10                  15      
Gly Arg Arg Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser His Lys Gly 
            20                  25                  30          
Pro Met Pro Phe 
        35      

<210> 4
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin-17

<400> 4
Lys Phe Arg Arg Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro 
1               5                   10                  15      
Phe 
    

<210> 5
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<221> MOD_RES
<222> 1
<223> PYRROLIDONE CARBOXYLIC ACID

<220> 
<223> pyr-apelin-13

<400> 5
Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              

<210> 6
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin-13

<400> 6
Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10              

<210> 7
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin-12

<400> 7
Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10          

<210> 8
<211> 21
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin epitope

<400> 8
Val Gln Pro Arg Gly Ser Arg Asn Gly Pro Gly Pro Trp Gln Gly Gly 
1               5                   10                  15      
Arg Arg Lys Phe Arg 
            20      

<210> 9
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin epitope

<400> 9
Arg Gly Ser Arg Asn Gly Pro Gly Pro Trp Gln Gly 
1               5                   10          

<210> 10
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin epitope

<400> 10
Arg Asn Gly Pro Gly Pro Trp 
1               5           

<210> 11
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin epitope

<400> 11
Pro Arg Leu Ser His Lys Gly Pro Met Pro Phe 
1               5                   10      

<210> 12
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin epitope

<400> 12
Pro Arg Leu Ser His Lys Gly 
1               5           

<210> 13
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin epitope

<400> 13
Leu Ser His Lys Gly Pro Met Pro 
1               5               

<210> 14
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin F13A

<400> 14
Gln Arg Pro Arg Leu Ser His Lys Gly Pro Met Pro Ala 
1               5                   10              

<210> 15
<211> 26
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 15
Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      
Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser 
            20                  25      

<210> 16
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 16
Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln Ser Glu Cys 
1               5                   10                  15      
Glu Tyr Thr Asp 
            20  

<210> 17
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 17
Asn Tyr Tyr Gly Ala Asp Asn Gln Ser Glu Cys Glu Tyr Thr Asp 
1               5                   10                  15  

<210> 18
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 18
Asp Asn Gln Ser Glu Cys Glu Tyr Thr Asp 
1               5                   10  

<210> 19
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 19
Ser Glu Cys Glu Tyr Thr Asp 
1               5           

<210> 20
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 20
Gly Asp Leu Glu Asn Thr Thr Lys 
1               5               

<210> 21
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> apelin receptor epitope

<400> 21
Asp Leu Glu Asn Thr Thr 
1               5       

<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> ALX40-4C

<400> 22
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   

<210> 23
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> cyclo(1-6)CRPRLC-KH-cyclo(9-14)CRPRLC

<400> 23
Cys Arg Pro Arg Leu Cys Lys His Cys Arg Pro Arg Leu Cys 
1               5                   10                  

