                         SEQUENCE LISTING

<110>  Acceleron Pharma, Inc.
 
<120>  BMPRII POLYPEPTIDES AND USES THEREOF

<130>  A0904.70011WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/319,241
<151>  2016-04-06

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  1038
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Asn Leu Ser His Asn Arg Arg Val Pro Lys Ile Gly Pro Tyr Pro 
    530                 535                 540                 


Asp Tyr Ser Ser Ser Ser Tyr Ile Glu Asp Ser Ile His His Thr Asp 
545                 550                 555                 560 


Ser Ile Val Lys Asn Ile Ser Ser Glu His Ser Met Ser Ser Thr Pro 
                565                 570                 575     


Leu Thr Ile Gly Glu Lys Asn Arg Asn Ser Ile Asn Tyr Glu Arg Gln 
            580                 585                 590         


Gln Ala Gln Ala Arg Ile Pro Ser Pro Glu Thr Ser Val Thr Ser Leu 
        595                 600                 605             


Ser Thr Asn Thr Thr Thr Thr Asn Thr Thr Gly Leu Thr Pro Ser Thr 
    610                 615                 620                 


Gly Met Thr Thr Ile Ser Glu Met Pro Tyr Pro Asp Glu Thr Asn Leu 
625                 630                 635                 640 


His Thr Thr Asn Val Ala Gln Ser Ile Gly Pro Thr Pro Val Cys Leu 
                645                 650                 655     


Gln Leu Thr Glu Glu Asp Leu Glu Thr Asn Lys Leu Asp Pro Lys Glu 
            660                 665                 670         


Val Asp Lys Asn Leu Lys Glu Ser Ser Asp Glu Asn Leu Met Glu His 
        675                 680                 685             


Ser Leu Lys Gln Phe Ser Gly Pro Asp Pro Leu Ser Ser Thr Ser Ser 
    690                 695                 700                 


Ser Leu Leu Tyr Pro Leu Ile Lys Leu Ala Val Glu Ala Thr Gly Gln 
705                 710                 715                 720 


Gln Asp Phe Thr Gln Thr Ala Asn Gly Gln Ala Cys Leu Ile Pro Asp 
                725                 730                 735     


Val Leu Pro Thr Gln Ile Tyr Pro Leu Pro Lys Gln Gln Asn Leu Pro 
            740                 745                 750         


Lys Arg Pro Thr Ser Leu Pro Leu Asn Thr Lys Asn Ser Thr Lys Glu 
        755                 760                 765             


Pro Arg Leu Lys Phe Gly Ser Lys His Lys Ser Asn Leu Lys Gln Val 
    770                 775                 780                 


Glu Thr Gly Val Ala Lys Met Asn Thr Ile Asn Ala Ala Glu Pro His 
785                 790                 795                 800 


Val Val Thr Val Thr Met Asn Gly Val Ala Gly Arg Asn His Ser Val 
                805                 810                 815     


Asn Ser His Ala Ala Thr Thr Gln Tyr Ala Asn Gly Thr Val Leu Ser 
            820                 825                 830         


Gly Gln Thr Thr Asn Ile Val Thr His Arg Ala Gln Glu Met Leu Gln 
        835                 840                 845             


Asn Gln Phe Ile Gly Glu Asp Thr Arg Leu Asn Ile Asn Ser Ser Pro 
    850                 855                 860                 


Asp Glu His Glu Pro Leu Leu Arg Arg Glu Gln Gln Ala Gly His Asp 
865                 870                 875                 880 


Glu Gly Val Leu Asp Arg Leu Val Asp Arg Arg Glu Arg Pro Leu Glu 
                885                 890                 895     


Gly Gly Arg Thr Asn Ser Asn Asn Asn Asn Ser Asn Pro Cys Ser Glu 
            900                 905                 910         


Gln Asp Val Leu Ala Gln Gly Val Pro Ser Thr Ala Ala Asp Pro Gly 
        915                 920                 925             


Pro Ser Lys Pro Arg Arg Ala Gln Arg Pro Asn Ser Leu Asp Leu Ser 
    930                 935                 940                 


Ala Thr Asn Val Leu Asp Gly Ser Ser Ile Gln Ile Gly Glu Ser Thr 
945                 950                 955                 960 


Gln Asp Gly Lys Ser Gly Ser Gly Glu Lys Ile Lys Lys Arg Val Lys 
                965                 970                 975     


Thr Pro Tyr Ser Leu Lys Arg Trp Arg Pro Ser Thr Trp Val Ile Ser 
            980                 985                 990         


Thr Glu Ser Leu Asp Cys Glu Val  Asn Asn Asn Gly Ser  Asn Arg Ala 
        995                 1000                 1005             


Val His  Ser Lys Ser Ser Thr  Ala Val Tyr Leu Ala  Glu Gly Gly 
    1010                 1015                 1020             


Thr Ala  Thr Thr Met Val Ser  Lys Asp Ile Gly Met  Asn Cys Leu 
    1025                 1030                 1035             


<210>  2
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Gln Asn Gln Glu Arg Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln 
1               5                   10                  15      


Asp Leu Gly Ile Gly Glu Ser Arg Ile Ser His Glu Asn Gly Thr Ile 
            20                  25                  30          


Leu Cys Ser Lys Gly Ser Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys 
        35                  40                  45              


Gly Asp Ile Asn Leu Val Lys Gln Gly Cys Trp Ser His Ile Gly Asp 
    50                  55                  60                  


Pro Gln Glu Cys His Tyr Glu Glu Cys Val Val Thr Thr Thr Pro Pro 
65                  70                  75                  80  


Ser Ile Gln Asn Gly Thr Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu 
                85                  90                  95      


Cys Asn Val Asn Phe Thr Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro 
            100                 105                 110         


Leu Ser Pro Pro His Ser Phe Asn Arg Asp Glu Thr 
        115                 120                 


<210>  3
<211>  3114
<212>  DNA
<213>  Homo sapiens

<400>  3
atgacttcct cgctgcagcg gccctggcgg gtgccctggc taccatggac catcctgctg       60

gtcagcactg cggctgcttc gcagaatcaa gaacggctat gtgcgtttaa agatccgtat      120

cagcaagacc ttgggatagg tgagagtaga atctctcatg aaaatgggac aatattatgc      180

tcgaaaggta gcacctgcta tggcctttgg gagaaatcaa aaggggacat aaatcttgta      240

aaacaaggat gttggtctca cattggagat ccccaagagt gtcactatga agaatgtgta      300

gtaactacca ctcctccctc aattcagaat ggaacatacc gtttctgctg ttgtagcaca      360

gatttatgta atgtcaactt tactgagaat tttccacctc ctgacacaac accactcagt      420

ccacctcatt catttaaccg agatgagaca ataatcattg ctttggcatc agtctctgta      480

ttagctgttt tgatagttgc cttatgcttt ggatacagaa tgttgacagg agaccgtaaa      540

caaggtcttc acagtatgaa catgatggag gcagcagcat ccgaaccctc tcttgatcta      600

gataatctga aactgttgga gctgattggc cgaggtcgat atggagcagt atataaaggc      660

tccttggatg agcgtccagt tgctgtaaaa gtgttttcct ttgcaaaccg tcagaatttt      720

atcaacgaaa agaacattta cagagtgcct ttgatggaac atgacaacat tgcccgcttt      780

atagttggag atgagagagt cactgcagat ggacgcatgg aatatttgct tgtgatggag      840

tactatccca atggatcttt atgcaagtat ttaagtctcc acacaagtga ctgggtaagc      900

tcttgccgtc ttgctcattc tgttactaga ggactggctt atcttcacac agaattacca      960

cgaggagatc attataaacc tgcaatttcc catcgagatt taaacagcag aaatgtccta     1020

gtgaaaaatg atggaacctg tgttattagt gactttggac tgtccatgag gctgactgga     1080

aatagactgg tgcgcccagg ggaggaagat aatgcagcca taagcgaggt tggcactatc     1140

agatatatgg caccagaagt gctagaagga gctgtgaact tgagggactg tgaatcagct     1200

ttgaaacaag tagacatgta tgctcttgga ctaatctatt gggagatatt tatgagatgt     1260

acagacctct tcccagggga atccgtacca gagtaccaga tggcttttca gacagaggtt     1320

ggaaaccatc ccacttttga ggatatgcag gttctcgtgt ctagggaaaa acagagaccc     1380

aagttcccag aagcctggaa agaaaatagc ctggcagtga ggtcactcaa ggagacaatc     1440

gaagactgtt gggaccagga tgcagaggct cggcttactg cacagtgtgc tgaggaaagg     1500

atggctgaac ttatgatgat ttgggaaaga aacaaatctg tgagcccaac agtcaatcca     1560

atgtctactg ctatgcagaa tgaacgcaac ctgtcacata ataggcgtgt gccaaaaatt     1620

ggtccttatc cagattattc ttcctcctca tacattgaag actctatcca tcatactgac     1680

agcatcgtga agaatatttc ctctgagcat tctatgtcca gcacaccttt gactataggg     1740

gaaaaaaacc gaaattcaat taactatgaa cgacagcaag cacaagctcg aatccccagc     1800

cctgaaacaa gtgtcaccag cctctccacc aacacaacaa ccacaaacac cacaggactc     1860

acgccaagta ctggcatgac tactatatct gagatgccat acccagatga aacaaatctg     1920

cataccacaa atgttgcaca gtcaattggg ccaacccctg tctgcttaca gctgacagaa     1980

gaagacttgg aaaccaacaa gctagaccca aaagaagttg ataagaacct caaggaaagc     2040

tctgatgaga atctcatgga gcactctctt aaacagttca gtggcccaga cccactgagc     2100

agtactagtt ctagcttgct ttacccactc ataaaacttg cagtagaagc aactggacag     2160

caggacttca cacagactgc aaatggccaa gcatgtttga ttcctgatgt tctgcctact     2220

cagatctatc ctctccccaa gcagcagaac cttcccaaga gacctactag tttgcctttg     2280

aacaccaaaa attcaacaaa agagccccgg ctaaaatttg gcagcaagca caaatcaaac     2340

ttgaaacaag tcgaaactgg agttgccaag atgaatacaa tcaatgcagc agaacctcat     2400

gtggtgacag tcaccatgaa tggtgtggca ggtagaaacc acagtgttaa ctcccatgct     2460

gccacaaccc aatatgccaa tgggacagta ctatctggcc aaacaaccaa catagtgaca     2520

catagggccc aagaaatgtt gcagaatcag tttattggtg aggacacccg gctgaatatt     2580

aattccagtc ctgatgagca tgagccttta ctgagacgag agcaacaagc tggccatgat     2640

gaaggtgttc tggatcgtct tgtggacagg agggaacggc cactagaagg tggccgaact     2700

aattccaata acaacaacag caatccatgt tcagaacaag atgttcttgc acagggtgtt     2760

ccaagcacag cagcagatcc tgggccatca aagcccagaa gagcacagag gcctaattct     2820

ctggatcttt cagccacaaa tgtcctggat ggcagcagta tacagatagg tgagtcaaca     2880

caagatggca aatcaggatc aggtgaaaag atcaagaaac gtgtgaaaac tccctattct     2940

cttaagcggt ggcgcccctc cacctgggtc atctccactg aatcgctgga ctgtgaagtc     3000

aacaataatg gcagtaacag ggcagttcat tccaaatcca gcactgctgt ttaccttgca     3060

gaaggaggca ctgctacaac catggtgtct aaagatatag gaatgaactg tctg           3114


<210>  4
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  4
tcgcagaatc aagaacggct atgtgcgttt aaagatccgt atcagcaaga ccttgggata       60

ggtgagagta gaatctctca tgaaaatggg acaatattat gctcgaaagg tagcacctgc      120

tatggccttt gggagaaatc aaaaggggac ataaatcttg taaaacaagg atgttggtct      180

cacattggag atccccaaga gtgtcactat gaagaatgtg tagtaactac cactcctccc      240

tcaattcaga atggaacata ccgtttctgc tgttgtagca cagatttatg taatgtcaac      300

tttactgaga attttccacc tcctgacaca acaccactca gtccacctca ttcatttaac      360

cgagatgaga ca                                                          372


<210>  5
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala Ser Gln Asn Gln Glu Arg 
            20                  25                  30          


Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu 
        35                  40                  45              


Ser Arg Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser 
    50                  55                  60                  


Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val 
65                  70                  75                  80  


Lys Gln Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr 
                85                  90                  95      


Glu Glu Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr 
            100                 105                 110         


Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr 
        115                 120                 125             


Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser 
    130                 135                 140                 


Phe Asn Arg Asp Glu Thr Ile Ile Ile Ala Leu Ala Ser Val Ser Val 
145                 150                 155                 160 


Leu Ala Val Leu Ile Val Ala Leu Cys Phe Gly Tyr Arg Met Leu Thr 
                165                 170                 175     


Gly Asp Arg Lys Gln Gly Leu His Ser Met Asn Met Met Glu Ala Ala 
            180                 185                 190         


Ala Ser Glu Pro Ser Leu Asp Leu Asp Asn Leu Lys Leu Leu Glu Leu 
        195                 200                 205             


Ile Gly Arg Gly Arg Tyr Gly Ala Val Tyr Lys Gly Ser Leu Asp Glu 
    210                 215                 220                 


Arg Pro Val Ala Val Lys Val Phe Ser Phe Ala Asn Arg Gln Asn Phe 
225                 230                 235                 240 


Ile Asn Glu Lys Asn Ile Tyr Arg Val Pro Leu Met Glu His Asp Asn 
                245                 250                 255     


Ile Ala Arg Phe Ile Val Gly Asp Glu Arg Val Thr Ala Asp Gly Arg 
            260                 265                 270         


Met Glu Tyr Leu Leu Val Met Glu Tyr Tyr Pro Asn Gly Ser Leu Cys 
        275                 280                 285             


Lys Tyr Leu Ser Leu His Thr Ser Asp Trp Val Ser Ser Cys Arg Leu 
    290                 295                 300                 


Ala His Ser Val Thr Arg Gly Leu Ala Tyr Leu His Thr Glu Leu Pro 
305                 310                 315                 320 


Arg Gly Asp His Tyr Lys Pro Ala Ile Ser His Arg Asp Leu Asn Ser 
                325                 330                 335     


Arg Asn Val Leu Val Lys Asn Asp Gly Thr Cys Val Ile Ser Asp Phe 
            340                 345                 350         


Gly Leu Ser Met Arg Leu Thr Gly Asn Arg Leu Val Arg Pro Gly Glu 
        355                 360                 365             


Glu Asp Asn Ala Ala Ile Ser Glu Val Gly Thr Ile Arg Tyr Met Ala 
    370                 375                 380                 


Pro Glu Val Leu Glu Gly Ala Val Asn Leu Arg Asp Cys Glu Ser Ala 
385                 390                 395                 400 


Leu Lys Gln Val Asp Met Tyr Ala Leu Gly Leu Ile Tyr Trp Glu Ile 
                405                 410                 415     


Phe Met Arg Cys Thr Asp Leu Phe Pro Gly Glu Ser Val Pro Glu Tyr 
            420                 425                 430         


Gln Met Ala Phe Gln Thr Glu Val Gly Asn His Pro Thr Phe Glu Asp 
        435                 440                 445             


Met Gln Val Leu Val Ser Arg Glu Lys Gln Arg Pro Lys Phe Pro Glu 
    450                 455                 460                 


Ala Trp Lys Glu Asn Ser Leu Ala Val Arg Ser Leu Lys Glu Thr Ile 
465                 470                 475                 480 


Glu Asp Cys Trp Asp Gln Asp Ala Glu Ala Arg Leu Thr Ala Gln Cys 
                485                 490                 495     


Ala Glu Glu Arg Met Ala Glu Leu Met Met Ile Trp Glu Arg Asn Lys 
            500                 505                 510         


Ser Val Ser Pro Thr Val Asn Pro Met Ser Thr Ala Met Gln Asn Glu 
        515                 520                 525             


Arg Arg 
    530 


<210>  6
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  6
atgacttcct cgctgcagcg gccctggcgg gtgccctggc taccatggac catcctgctg       60

gtcagcactg cggctgcttc gcagaatcaa gaacggctat gtgcgtttaa agatccgtat      120

cagcaagacc ttgggatagg tgagagtaga atctctcatg aaaatgggac aatattatgc      180

tcgaaaggta gcacctgcta tggcctttgg gagaaatcaa aaggggacat aaatcttgta      240

aaacaaggat gttggtctca cattggagat ccccaagagt gtcactatga agaatgtgta      300

gtaactacca ctcctccctc aattcagaat ggaacatacc gtttctgctg ttgtagcaca      360

gatttatgta atgtcaactt tactgagaat tttccacctc ctgacacaac accactcagt      420

ccacctcatt catttaaccg agatgagaca ataatcattg ctttggcatc agtctctgta      480

ttagctgttt tgatagttgc cttatgcttt ggatacagaa tgttgacagg agaccgtaaa      540

caaggtcttc acagtatgaa catgatggag gcagcagcat ccgaaccctc tcttgatcta      600

gataatctga aactgttgga gctgattggc cgaggtcgat atggagcagt atataaaggc      660

tccttggatg agcgtccagt tgctgtaaaa gtgttttcct ttgcaaaccg tcagaatttt      720

atcaacgaaa agaacattta cagagtgcct ttgatggaac atgacaacat tgcccgcttt      780

atagttggag atgagagagt cactgcagat ggacgcatgg aatatttgct tgtgatggag      840

tactatccca atggatcttt atgcaagtat ttaagtctcc acacaagtga ctgggtaagc      900

tcttgccgtc ttgctcattc tgttactaga ggactggctt atcttcacac agaattacca      960

cgaggagatc attataaacc tgcaatttcc catcgagatt taaacagcag aaatgtccta     1020

gtgaaaaatg atggaacctg tgttattagt gactttggac tgtccatgag gctgactgga     1080

aatagactgg tgcgcccagg ggaggaagat aatgcagcca taagcgaggt tggcactatc     1140

agatatatgg caccagaagt gctagaagga gctgtgaact tgagggactg tgaatcagct     1200

ttgaaacaag tagacatgta tgctcttgga ctaatctatt gggagatatt tatgagatgt     1260

acagacctct tcccagggga atccgtacca gagtaccaga tggcttttca gacagaggtt     1320

ggaaaccatc ccacttttga ggatatgcag gttctcgtgt ctagggaaaa acagagaccc     1380

aagttcccag aagcctggaa agaaaatagc ctggcagtga ggtcactcaa ggagacaatc     1440

gaagactgtt gggaccagga tgcagaggct cggcttactg cacagtgtgc tgaggaaagg     1500

atggctgaac ttatgatgat ttgggaaaga aacaaatctg tgagcccaac agtcaatcca     1560

atgtctactg ctatgcagaa tgaacgtagg                                      1590


<210>  7
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  8
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  8

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  9
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  10
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
    50                  55                  60                  


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
65                  70                  75                  80  


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                85                  90                  95      


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp 
            100                 105                 110         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        115                 120                 125             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    130                 135                 140                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
145                 150                 155                 160 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                165                 170                 175     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            180                 185                 190         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        195                 200                 205             


Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn 
    210                 215                 220                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
225                 230                 235                 240 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser 
                245                 250                 255     


Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser 
            260                 265                 270         


Leu Ser Leu Ser Pro Gly Lys 
        275                 


<210>  11
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  12
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Ser Ser Leu Gln Arg Pro Trp Arg Val Pro Trp Leu Pro Trp 
1               5                   10                  15      


Thr Ile Leu Leu Val Ser Thr Ala Ala Ala 
            20                  25      


<210>  13
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala 
            20                  


<210>  14
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Gly Ala Ser Gln Asn Gln Glu Arg Leu Cys 
            20                  25                  30          


Ala Phe Lys Asp Pro Tyr Gln Gln Asp Leu Gly Ile Gly Glu Ser Arg 
        35                  40                  45              


Ile Ser His Glu Asn Gly Thr Ile Leu Cys Ser Lys Gly Ser Thr Cys 
    50                  55                  60                  


Tyr Gly Leu Trp Glu Lys Ser Lys Gly Asp Ile Asn Leu Val Lys Gln 
65                  70                  75                  80  


Gly Cys Trp Ser His Ile Gly Asp Pro Gln Glu Cys His Tyr Glu Glu 
                85                  90                  95      


Cys Val Val Thr Thr Thr Pro Pro Ser Ile Gln Asn Gly Thr Tyr Arg 
            100                 105                 110         


Phe Cys Cys Cys Ser Thr Asp Leu Cys Asn Val Asn Phe Thr Glu Asn 
        115                 120                 125             


Phe Pro Pro Pro Asp Thr Thr Pro Leu Ser Pro Pro His Ser Phe Asn 
    130                 135                 140                 


Arg Asp Glu Thr Gly Gly Gly Thr His Thr Cys Pro Pro Cys Pro Ala 
145                 150                 155                 160 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                165                 170                 175     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            180                 185                 190         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        195                 200                 205             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    210                 215                 220                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
225                 230                 235                 240 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                245                 250                 255     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            260                 265                 270         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        275                 280                 285             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    290                 295                 300                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
305                 310                 315                 320 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                325                 330                 335     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            340                 345                 350         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        355                 360                 365             


Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375     


<210>  15
<211>  1128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial polynucleotide

<400>  15
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggagc agtcttcgtt       60

tcgcccggcg cctcgcagaa tcaagaacgc ctatgtgcgt ttaaagatcc gtatcagcaa      120

gaccttggga taggtgagag tagaatctct catgaaaatg ggacaatatt atgctcgaaa      180

ggtagcacct gctatggcct ttgggagaaa tcaaaagggg acataaatct tgtaaaacaa      240

ggatgttggt ctcacattgg agatccccaa gagtgtcact atgaagaatg tgtagtaact      300

accactcctc cctcaattca gaatggaaca taccgtttct gctgttgtag cacagattta      360

tgtaatgtca actttactga gaattttcca cctcctgaca caacaccact cagtccacct      420

cattcattta accgagatga gaccggtggt ggaactcaca catgcccacc gtgcccagca      480

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      540

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      600

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      660

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      720

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      780

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      840

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      900

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      960

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1020

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1080

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1128


<210>  16
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide

<400>  16

Ser Gln Asn Gln Glu Arg Leu Cys Ala Phe Lys Asp Pro Tyr Gln Gln 
1               5                   10                  15      


Asp Leu Gly Ile Gly Glu Ser Arg Ile Ser His Glu Asn Gly Thr Ile 
            20                  25                  30          


Leu Cys Ser Lys Gly Ser Thr Cys Tyr Gly Leu Trp Glu Lys Ser Lys 
        35                  40                  45              


Gly Asp Ile Asn Leu Val Lys Gln Gly Cys Trp Ser His Ile Gly Asp 
    50                  55                  60                  


Pro Gln Glu Cys His Tyr Glu Glu Cys Val Val Thr Thr Thr Pro Pro 
65                  70                  75                  80  


Ser Ile Gln Asn Gly Thr Tyr Arg Phe Cys Cys Cys Ser Thr Asp Leu 
                85                  90                  95      


Cys Asn Val Asn Phe Thr Glu Asn Phe Pro Pro Pro Asp Thr Thr Pro 
            100                 105                 110         


Leu Ser Pro Pro His Ser Phe Asn Arg Asp Glu Thr Gly Gly Gly Thr 
        115                 120                 125             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
145                 150                 155                 160 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                165                 170                 175     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            180                 185                 190         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        195                 200                 205             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    210                 215                 220                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
225                 230                 235                 240 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                245                 250                 255     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            260                 265                 270         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        275                 280                 285             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
305                 310                 315                 320 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                325                 330                 335     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350         


<210>  17
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  17
tcgcagaatc aagaacgcct atgtgcgttt aaagatccgt atcagcaaga ccttgggata       60

ggtgagagta gaatctctca tgaaaatggg acaatattat gctcgaaagg tagcacctgc      120

tatggccttt gggagaaatc aaaaggggac ataaatcttg taaaacaagg atgttggtct      180

cacattggag atccccaaga gtgtcactat gaagaatgtg tagtaactac cactcctccc      240

tcaattcaga atggaacata ccgtttctgc tgttgtagca cagatttatg taatgtcaac      300

tttactgaga attttccacc tcctgacaca acaccactca gtccacctca ttcatttaac      360

cgagatgaga ccggtggtgg aactcacaca tgcccaccgt gcccagcacc tgaactcctg      420

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      480

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      540

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      600

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      660

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      720

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      780

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      840

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      900

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc      960

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1020

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1056


<210>  18

<400>  18
000

<210>  19

<400>  19
000

<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Thr Gly Gly Gly 
1               


<210>  21
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Gly Gly Gly 
1           


