                         SEQUENCE LISTING

<110>  Orphazyme ApS
 
<120>  Heat Shock Protein 70 and Diseases Associated with Dysregulation 
       of Cholesterol Homeostasis

<130>  P4168PC00

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  2
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser Cys 
1               5                   10                  15      


Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp Gln 
            20                  25                  30          


Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg 
        35                  40                  45              


Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln Asn 
    50                  55                  60                  


Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp Pro 
65                  70                  75                  80  


Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn Asp 
                85                  90                  95      


Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys Ala 
            100                 105                 110         


Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys Glu 
        115                 120                 125             


Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile Thr 
    130                 135                 140                 


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
145                 150                 155                 160 


Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr 
                165                 170                 175     


Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu Arg 
            180                 185                 190         


Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser Ile 
        195                 200                 205             


Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly Asp 
    210                 215                 220                 


Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His Phe 
225                 230                 235                 240 


Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn Lys 
                245                 250                 255     


Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg Thr 
            260                 265                 270         


Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe Glu 
        275                 280                 285             


Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu Leu 
    290                 295                 300                 


Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala Leu 
305                 310                 315                 320 


Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu Val 
                325                 330                 335     


Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp Phe 
            340                 345                 350         


Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala Val 
        355                 360                 365             


Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys Ser 
    370                 375                 380                 


Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser Leu 
385                 390                 395                 400 


Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg Asn 
                405                 410                 415     


Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser Asp 
            420                 425                 430         


Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala Met 
        435                 440                 445             


Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile Pro 
    450                 455                 460                 


Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp 
465                 470                 475                 480 


Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly Lys 
                485                 490                 495     


Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys Glu 
            500                 505                 510         


Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu Asp 
        515                 520                 525             


Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser Tyr 
    530                 535                 540                 


Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly Lys 
545                 550                 555                 560 


Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu Val 
                565                 570                 575     


Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe Glu 
            580                 585                 590         


His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser Gly 
        595                 600                 605             


Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala Gln 
    610                 615                 620                 


Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val Asp 
625                 630                 635                 640 


<210>  3
<211>  2445
<212>  DNA
<213>  Homo sapiens

<400>  3
ataaaagccc aggggcaagc ggtccggata acggctagcc tgaggagctg ctgcgacagt       60

ccactacctt tttcgagagt gactcccgtt gtcccaaggc ttcccagagc gaacctgtgc      120

ggctgcaggc accggcgcgt cgagtttccg gcgtccggaa ggaccgagct cttctcgcgg      180

atccagtgtt ccgtttccag cccccaatct cagagcggag ccgacagaga gcagggaacc      240

ggcatggcca aagccgcggc gatcggcatc gacctgggca ccacctactc ctgcgtgggg      300

gtgttccaac acggcaaggt ggagatcatc gccaacgacc agggcaaccg caccaccccc      360

agctacgtgg ccttcacgga caccgagcgg ctcatcgggg atgcggccaa gaaccaggtg      420

gcgctgaacc cgcagaacac cgtgtttgac gcgaagcggc tgattggccg caagttcggc      480

gacccggtgg tgcagtcgga catgaagcac tggcctttcc aggtgatcaa cgacggagac      540

aagcccaagg tgcaggtgag ctacaagggg gagaccaagg cattctaccc cgaggagatc      600

tcgtccatgg tgctgaccaa gatgaaggag atcgccgagg cgtacctggg ctacccggtg      660

accaacgcgg tgatcaccgt gccggcctac ttcaacgact cgcagcgcca ggccaccaag      720

gatgcgggtg tgatcgcggg gctcaacgtg ctgcggatca tcaacgagcc cacggccgcc      780

gccatcgcct acggcctgga cagaacgggc aagggggagc gcaacgtgct catctttgac      840

ctgggcgggg gcaccttcga cgtgtccatc ctgacgatcg acgacggcat cttcgaggtg      900

aaggccacgg ccggggacac ccacctgggt ggggaggact ttgacaacag gctggtgaac      960

cacttcgtgg aggagttcaa gagaaaacac aagaaggaca tcagccagaa caagcgagcc     1020

gtgaggcggc tgcgcaccgc ctgcgagagg gccaagagga ccctgtcgtc cagcacccag     1080

gccagcctgg agatcgactc cctgtttgag ggcatcgact tctacacgtc catcaccagg     1140

gcgaggttcg aggagctgtg ctccgacctg ttccgaagca ccctggagcc cgtggagaag     1200

gctctgcgcg acgccaagct ggacaaggcc cagattcacg acctggtcct ggtcgggggc     1260

tccacccgca tccccaaggt gcagaagctg ctgcaggact tcttcaacgg gcgcgacctg     1320

aacaagagca tcaaccccga cgaggctgtg gcctacgggg cggcggtgca ggcggccatc     1380

ctgatggggg acaagtccga gaacgtgcag gacctgctgc tgctggacgt ggctcccctg     1440

tcgctggggc tggagacggc cggaggcgtg atgactgccc tgatcaagcg caactccacc     1500

atccccacca agcagacgca gatcttcacc acctactccg acaaccaacc cggggtgctg     1560

atccaggtgt acgagggcga gagggccatg acgaaagaca acaatctgtt ggggcgcttc     1620

gagctgagcg gcatccctcc ggcccccagg ggcgtgcccc agatcgaggt gaccttcgac     1680

atcgatgcca acggcatcct gaacgtcacg gccacggaca agagcaccgg caaggccaac     1740

aagatcacca tcaccaacga caagggccgc ctgagcaagg aggagatcga gcgcatggtg     1800

caggaggcgg agaagtacaa agcggaggac gaggtgcagc gcgagagggt gtcagccaag     1860

aacgccctgg agtcctacgc cttcaacatg aagagcgccg tggaggatga ggggctcaag     1920

ggcaagatca gcgaggcgga caagaagaag gtgctggaca agtgtcaaga ggtcatctcg     1980

tggctggacg ccaacacctt ggccgagaag gacgagtttg agcacaagag gaaggagctg     2040

gagcaggtgt gtaaccccat catcagcgga ctgtaccagg gtgccggtgg tcccgggcct     2100

gggggcttcg gggctcaggg tcccaaggga gggtctgggt caggccccac cattgaggag     2160

gtagattagg ggcctttcca agattgctgt ttttgttttg gagcttcaag actttgcatt     2220

tcctagtatt tctgtttgtc agttctcaat ttcctgtgtt tgcaatgttg aaattttttg     2280

gtgaagtact gaacttgctt tttttccggt ttctacatgc agagatgaat ttatactgcc     2340

atcttacgac tatttcttct ttttaataca cttaactcag gccatttttt aagttggtta     2400

cttcaaagta aataaacttt aaaattcaaa aaaaaaaaaa aaaaa                     2445


<210>  4
<211>  641
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  5
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser Cys 
1               5                   10                  15      


Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp Gln 
            20                  25                  30          


Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu Arg 
        35                  40                  45              


Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln Asn 
    50                  55                  60                  


Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp Pro 
65                  70                  75                  80  


Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn Asp 
                85                  90                  95      


Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys Ala 
            100                 105                 110         


Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys Glu 
        115                 120                 125             


Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile Thr 
    130                 135                 140                 


Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp Ala 
145                 150                 155                 160 


Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro Thr 
                165                 170                 175     


Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu Arg 
            180                 185                 190         


Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser Ile 
        195                 200                 205             


Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly Asp 
    210                 215                 220                 


Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His Phe 
225                 230                 235                 240 


Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn Lys 
                245                 250                 255     


Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg Thr 
            260                 265                 270         


Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe Glu 
        275                 280                 285             


Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu Leu 
    290                 295                 300                 


Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala Leu 
305                 310                 315                 320 


Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu Val 
                325                 330                 335     


Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp Phe 
            340                 345                 350         


Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala Val 
        355                 360                 365             


Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys Ser 
    370                 375                 380                 


Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser Leu 
385                 390                 395                 400 


Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg Asn 
                405                 410                 415     


Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser Asp 
            420                 425                 430         


Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala Met 
        435                 440                 445             


Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile Pro 
    450                 455                 460                 


Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile Asp 
465                 470                 475                 480 


Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly Lys 
                485                 490                 495     


Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys Glu 
            500                 505                 510         


Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu Asp 
        515                 520                 525             


Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser Tyr 
    530                 535                 540                 


Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly Lys 
545                 550                 555                 560 


Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu Val 
                565                 570                 575     


Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe Glu 
            580                 585                 590         


His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser Gly 
        595                 600                 605             


Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala Gln 
    610                 615                 620                 


Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val Asp 
625                 630                 635                 640 


<210>  6
<211>  2551
<212>  DNA
<213>  Homo sapiens

<400>  6
ggaaaacggc cagcctgagg agctgctgcg agggtccgct tcgtctttcg agagtgactc       60

ccgcggtccc aaggctttcc agagcgaacc tgtgcggctg caggcaccgg cgtgttgagt      120

ttccggcgtt ccgaaggact gagctcttgt cgcggatccc gtccgccgtt tccagccccc      180

agtctcagag cggagcccac agagcagggc accggcatgg ccaaagccgc ggcgatcggc      240

atcgacctgg gcaccaccta ctcctgcgtg ggggtgttcc aacacggcaa ggtggagatc      300

atcgccaacg accagggcaa ccgcaccacc cccagctacg tggccttcac ggacaccgag      360

cggctcatcg gggatgcggc caagaaccag gtggcgctga acccgcagaa caccgtgttt      420

gacgcgaagc ggctgatcgg ccgcaagttc ggcgacccgg tggtgcagtc ggacatgaag      480

cactggcctt tccaggtgat caacgacgga gacaagccca aggtgcaggt gagctacaag      540

ggggagacca aggcattcta ccccgaggag atctcgtcca tggtgctgac caagatgaag      600

gagatcgccg aggcgtacct gggctacccg gtgaccaacg cggtgatcac cgtgccggcc      660

tacttcaacg actcgcagcg ccaggccacc aaggatgcgg gtgtgatcgc ggggctcaac      720

gtgctgcgga tcatcaacga gcccacggcc gccgccatcg cctacggcct ggacagaacg      780

ggcaaggggg agcgcaacgt gctcatcttt gacctgggcg ggggcacctt cgacgtgtcc      840

atcctgacga tcgacgacgg catcttcgag gtgaaggcca cggccgggga cacccacctg      900

ggtggggagg actttgacaa caggctggtg aaccacttcg tggaggagtt caagagaaaa      960

cacaagaagg acatcagcca gaacaagcga gccgtgaggc ggctgcgcac cgcctgcgag     1020

agggccaaga ggaccctgtc gtccagcacc caggccagcc tggagatcga ctccctgttt     1080

gagggcatcg acttctacac gtccatcacc agggcgaggt tcgaggagct gtgctccgac     1140

ctgttccgaa gcaccctgga gcccgtggag aaggctctgc gcgacgccaa gctggacaag     1200

gcccagattc acgacctggt cctggtcggg ggctccaccc gcatccccaa ggtgcagaag     1260

ctgctgcagg acttcttcaa cgggcgcgac ctgaacaaga gcatcaaccc cgacgaggct     1320

gtggcctacg gggcggcggt gcaggcggcc atcctgatgg gggacaagtc cgagaacgtg     1380

caggacctgc tgctgctgga cgtggctccc ctgtcgctgg ggctggagac ggccggaggc     1440

gtgatgactg ccctgatcaa gcgcaactcc accatcccca ccaagcagac gcagatcttc     1500

accacctact ccgacaacca acccggggtg ctgatccagg tgtacgaggg cgagagggcc     1560

atgacgaaag acaacaatct gttggggcgc ttcgagctga gcggcatccc tccggccccc     1620

aggggcgtgc cccagatcga ggtgaccttc gacatcgatg ccaacggcat cctgaacgtc     1680

acggccacgg acaagagcac cggcaaggcc aacaagatca ccatcaccaa cgacaagggc     1740

cgcctgagca aggaggagat cgagcgcatg gtgcaggagg cggagaagta caaagcggag     1800

gacgaggtgc agcgcgagag ggtgtcagcc aagaacgccc tggagtccta cgccttcaac     1860

atgaagagcg ccgtggagga tgaggggctc aagggcaaga tcagcgaggc ggacaagaag     1920

aaggttctgg acaagtgtca agaggtcatc tcgtggctgg acgccaacac cttggccgag     1980

aaggacgagt ttgagcacaa gaggaaggag ctggagcagg tgtgtaaccc catcatcagc     2040

ggactgtacc agggtgccgg tggtcccggg cctggcggct tcggggctca gggtcccaag     2100

ggagggtctg ggtcaggccc taccattgag gaggtggatt aggggccttt gttctttagt     2160

atgtttgtct ttgaggtgga ctgttgggac tcaaggactt tgctgctgtt ttcctatgtc     2220

atttctgctt cagctctttg ctgcttcact tctttgtaaa gttgtaacct gatggtaatt     2280

agctggcttc attatttttg tagtacaacc gatatgttca ttagaattct ttgcatttaa     2340

tgttgatact gtaagggtgt ttcgttccct ttaaatgaat caacactgcc accttctgta     2400

cgagtttgtt tgtttttttt tttttttttt ttttttgctt ggcgaaaaca ctacaaaggc     2460

tgggaatgta tgtttttata atttgtttat ttaaatatga aaaataaaat gttaaacttt     2520

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a                                    2551


