                         SEQUENCE LISTING

<110>  Universiteit Maastricht and Academisch Ziekenhuis 
       Maastricht
 
<120>  METHOD FOR THE TREATMENT OR PREVENTION OF OSTEOARTHRITIS

<130>  331 WO

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  homo sapiens

<400>  1

Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu 
1               5                   10                  15      


Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala Ile 
            20                  25                  30          


Val 
    


<210>  2
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  2

Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu 
1               5                   10                  15      


Ser Ala Phe Pro 
            20  


<210>  3
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  3

Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser 
1               5                   10                  15      


Ala Phe Pro Leu 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  4

Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala 
1               5                   10                  15      


Phe Pro Leu Asn 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  5

Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe 
1               5                   10                  15      


Pro Leu Asn Ser 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  6

Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro 
1               5                   10                  15      


Leu Asn Ser Tyr 
            20  


<210>  7
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  7

Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu 
1               5                   10                  15      


Asn Ser Tyr Met 
            20  


<210>  8
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  8

Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn 
1               5                   10                  15      


Ser Tyr Met Asn 
            20  


<210>  9
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  9

Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10                  15      


Tyr Met Asn Ala 
            20  


<210>  10
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  10

Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr 
1               5                   10                  15      


Met Asn Ala Thr 
            20  


<210>  11
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  11

Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met 
1               5                   10                  15      


Asn Ala Thr Asn 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  12

Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn 
1               5                   10                  15      


Ala Thr Asn His 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  13

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala 
1               5                   10                  15      


Thr Asn His Ala 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  14

Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr 
1               5                   10                  15      


Asn His Ala Ile 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  15

Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn 
1               5                   10                  15      


His Ala Ile Val 
            20  


<210>  16
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  16

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10          


<210>  17
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  17

Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe 
1               5                   10                  15      


Pro Leu Asn Ser 
            20  


<210>  18
<211>  19
<212>  PRT
<213>  homo sapiens

<400>  18

Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro 
1               5                   10                  15      


Leu Asn Ser 
            


<210>  19
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  19

Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu 
1               5                   10                  15      


Asn Ser 
        


<210>  20
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  20

Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn 
1               5                   10                  15      


Ser 
    


<210>  21
<211>  16
<212>  PRT
<213>  homo sapiens

<400>  21

Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10                  15      


<210>  22
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  22

Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10                  15  


<210>  23
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  23

Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10                  


<210>  24
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  24

Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10              


<210>  25
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  25

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser 
1               5                   10          


<210>  26
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  26

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr 
1               5                   10              


<210>  27
<211>  14
<212>  PRT
<213>  homo sapiens

<400>  27

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met 
1               5                   10                  


<210>  28
<211>  15
<212>  PRT
<213>  homo sapiens

<400>  28

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn 
1               5                   10                  15  


<210>  29
<211>  16
<212>  PRT
<213>  homo sapiens

<400>  29

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala 
1               5                   10                  15      


<210>  30
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  30

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala 
1               5                   10                  15      


Thr 
    


<210>  31
<211>  18
<212>  PRT
<213>  homo sapiens

<400>  31

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala 
1               5                   10                  15      


Thr Asn 
        


<210>  32
<211>  19
<212>  PRT
<213>  homo sapiens

<400>  32

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala 
1               5                   10                  15      


Thr Asn His 
            


<210>  33
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  33

Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn Ala 
1               5                   10                  15      


Thr Asn His Ala 
            20  


<210>  34
<211>  28
<212>  PRT
<213>  homo sapiens

<400>  34

Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe 
1               5                   10                  15      


Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala 
            20                  25              


<210>  35
<211>  27
<212>  PRT
<213>  homo sapiens

<400>  35

Pro Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro 
1               5                   10                  15      


Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala 
            20                  25          


<210>  36
<211>  26
<212>  PRT
<213>  homo sapiens

<400>  36

Glu Gly Tyr Ala Ala Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu 
1               5                   10                  15      


Asn Ser Tyr Met Asn Ala Thr Asn His Ala 
            20                  25      


<210>  37
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  37

Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  38

Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser Asp Gln 
1               5                   10                  15      


Arg Gln Ala Cys 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  39

Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp 
1               5                   10                  15      


Gln Asp Trp Ile 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  40

Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Tyr Tyr Cys Glu Gly Glu 
1               5                   10                  15      


Cys Ala Phe Pro 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  41

Phe Pro Leu Asn Ser Tyr Met Asn Ala Thr Asn His Ala Ile Val Gln 
1               5                   10                  15      


Thr Leu Val His 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  42

Val His Phe Ile Asn Pro Glu Thr Val Pro Lys Pro Cys Cys Ala Pro 
1               5                   10                  15      


Thr Gln Leu Asn 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  43

Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile 
1               5                   10                  15      


Leu Lys Lys Tyr 
            20  


<210>  44
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  44

Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ala 
1               5                   10                  15      


Cys Gly Cys His 
            20  


<210>  45
<211>  139
<212>  PRT
<213>  homo sapiens

<400>  45

Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210>  46
<211>  139
<212>  PRT
<213>  homo sapiens

<400>  46

Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Ser Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Ser Glu Gly Glu Ser Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Ser Ser Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Ser Gly Ser His 
    130                 135                 


<210>  47
<211>  28
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Xaa Xaa Xaa Gly Tyr Xaa Ala Xaa Tyr Ser Glu Gly Xaa Ser Xaa Xaa 
1               5                   10                  15      


Xaa Leu Xaa Xaa Xaa Met Asn Ala Thr Xaa His Ala 
            20                  25              


<210>  48
<211>  12
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  48

Tyr Ser Glu Gly Xaa Ser Xaa Xaa Xaa Leu Xaa Xaa 
1               5                   10          


<210>  49
<211>  20
<212>  PRT
<213>  homo sapiens

<400>  49

Ser Phe Ile Leu Lys Lys Val Leu Tyr Asp Arg Val Asn Asp Ser Ala 
1               5                   10                  15      


Asn Ile Tyr Ser 
            20  


