                         SEQUENCE LISTING

<110>  Zhao, Aizhi
       Wen, Weihong
       Han, Yueheng
 
<120>  Anti-PSMA antibodies and use thereof

<130>  168273.00100

<150>  62/321975
<151>  2016-04-13

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Ser Ser Asn Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys 
1               5                   10                  15      


Ala Phe Leu Asp Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr 
            20                  25                  30          


Asn Phe Thr Gln Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln 
        35                  40                  45              


Leu Ala Lys Gln Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser 
    50                  55                  60                  


Val Glu Leu Ala His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr 
65                  70                  75                  80  


His Pro Asn Tyr Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe 
                85                  90                  95      


Asn Thr Ser Leu Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser 
            100                 105                 110         


Asp Ile Val Pro Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu 
        115                 120                 125             


Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys 
    130                 135                 140                 


Leu Glu Arg Asp Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala 
145                 150                 155                 160 


Arg Tyr Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu 
                165                 170                 175     


Ala Gly Ala Lys Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe 
            180                 185                 190         


Ala Pro Gly Val Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly 
        195                 200                 205             


Gly Val Gln Arg Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro 
    210                 215                 220                 


Leu Thr Pro Gly Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile 
225                 230                 235                 240 


Ala Glu Ala Val Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr 
                245                 250                 255     


Tyr Asp Ala Gln Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro 
            260                 265                 270         


Asp Ser Ser Trp Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro 
        275                 280                 285             


Gly Phe Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His Ile His 
    290                 295                 300                 


Ser Thr Asn Glu Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg 
305                 310                 315                 320 


Gly Ala Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp 
                325                 330                 335     


Ser Trp Val Phe Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val 
            340                 345                 350         


His Glu Ile Val Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg 
        355                 360                 365             


Pro Arg Arg Thr Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly 
    370                 375                 380                 


Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln 
385                 390                 395                 400 


Glu Arg Gly Val Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn 
                405                 410                 415     


Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His 
            420                 425                 430         


Asn Leu Thr Lys Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys 
        435                 440                 445             


Ser Leu Tyr Glu Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser 
    450                 455                 460                 


Gly Met Pro Arg Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val 
465                 470                 475                 480 


Phe Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys 
                485                 490                 495     


Asn Trp Glu Thr Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val 
            500                 505                 510         


Tyr Glu Thr Tyr Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys 
        515                 520                 525             


Tyr His Leu Thr Val Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu 
    530                 535                 540                 


Ala Asn Ser Ile Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val 
545                 550                 555                 560 


Leu Arg Lys Tyr Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro 
                565                 570                 575     


Gln Glu Met Lys Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala 
            580                 585                 590         


Val Lys Asn Phe Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln 
        595                 600                 605             


Asp Phe Asp Lys Ser Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln 
    610                 615                 620                 


Leu Met Phe Leu Glu Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp 
625                 630                 635                 640 


Arg Pro Phe Tyr Arg His Val Ile Tyr Ala Pro Ser Ser His Asn Lys 
                645                 650                 655     


Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile 
            660                 665                 670         


Glu Ser Lys Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln 
        675                 680                 685             


Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser 
    690                 695                 700                 


Glu Val Ala 
705         


<210>  2
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  2
cagtctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag tgtcattatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttctc atgtacactg gtaccagcag      120

gttccaggaa cagcccccaa actcctcatc tatggaaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcaggtt ccctggccat cactggactc      240

cagcctgagg atgaggctga ttattattgt gcaacatggg atgacagtct gaatggtgta      300

atattcggcg gagggaccaa ggtcaccgtc ctaggcggat cctctaggtc aagttccagc      360

ggcggcggtg gcagcggagg cggcggtgag gtgcagctgg tggagtctgg gggagccctg      420

gccaagcctg gggggtccct gagactctcc tgtgcagcct ctggatccac cctcagtggc      480

tatgctatgc actgggtccg ccaggctcca ggcaaggggc tggagtgggt ggcagttata      540

tcatatgatg gaagcaataa atactacgca gactccgtga agggccgatt caccatctcc      600

agagacaatt ccaagaacac gctgtttctg caaatgaaca gcctgagacc tgaggacacg      660

gctgtgtact attgtgctaa aggccttact tggggactcg gtgacaatga tgctctcgat      720

atctggggcc ccgggaccac ggtcaccgtc tcctca                                756


<210>  3
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  3

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys Pro Gly 
    130                 135                 140                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Ser Gly 
145                 150                 155                 160 


Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser 
            180                 185                 190         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        195                 200                 205             


Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala Leu Asp 
225                 230                 235                 240 


Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
                245                 250         


<210>  4
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  4
cagtctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag tgtcattatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttctc atgtacactg gtaccagcag      120

gttccaggaa cagcccccaa actcctcatc tatggaaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcaggtt ccctggccat cactggactc      240

cagcctgagg atgaggctga ttattattgt gcaacatggg atgacagtct gaatggtgta      300

atattcggcg gagggaccaa ggtcaccgtc cta                                   333


<210>  5
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  6
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  6
cagtctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag tgtcattatc       60

tcctgcactg ggagc                                                        75


<210>  7
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ile Ile Ser Cys Thr Gly Ser 
            20                  25  


<210>  8
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  8
agctccaaca tcggggcagg ttctcat                                           27


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Ser Asn Ile Gly Ala Gly Ser His 
1               5                   


<210>  10
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  10
gtacactggt accagcaggt tccaggaaca gcccccaaac tcctcatcta t                51


<210>  11
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  11

Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  12
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  12
ggaaacacc                                                                9


<210>  13
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Asn Thr 
1           


<210>  14
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  14
aatcggccct caggggtccc tgaccgattc tctggctcca agtctggcac ctcaggttcc       60

ctggccatca ctggactcca gcctgaggat gaggctgatt attattgt                   108


<210>  15
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  15

Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
1               5                   10                  15      


Thr Ser Gly Ser Leu Ala Ile Thr Gly Leu Gln Pro Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  16
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  16
gcaacatggg atgacagtct gaatggtgta ata                                    33


<210>  17
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Thr Trp Asp Asp Ser Leu Asn Gly Val Ile 
1               5                   10      


<210>  18
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  18
ttcggcggag ggaccaaggt caccgtccta                                        30


<210>  19
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
1               5                   10  


<210>  20
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  20
gaggtgcagc tggtggagtc tgggggagcc ctggccaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatc caccctcagt ggctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgttt      240

ctgcaaatga acagcctgag acctgaggac acggctgtgt actattgtgc taaaggcctt      300

acttggggac tcggtgacaa tgatgctctc gatatctggg gccccgggac cacggtcacc      360

gtctcctca                                                              369


<210>  21
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Ser Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala Leu Asp Ile 
            100                 105                 110         


Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  22
<211>  75
<212>  DNA
<213>  Homo sapiens

<400>  22
gaggtgcagc tggtggagtc tgggggagcc ctggccaagc ctggggggtc cctgagactc       60

tcctgtgcag cctct                                                        75


<210>  23
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  24
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  24
ggatccaccc tcagtggcta tgct                                              24


<210>  25
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ser Thr Leu Ser Gly Tyr Ala 
1               5               


<210>  26
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  26
atgcactggg tccgccaggc tccaggcaag gggctggagt gggtggcagt t                51


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Val 
    


<210>  28
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  28
atatcatatg atggaagcaa taaa                                              24


<210>  29
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  29

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  30
<211>  114
<212>  DNA
<213>  Homo sapiens

<400>  30
tactacgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg       60

ctgtttctgc aaatgaacag cctgagacct gaggacacgg ctgtgtacta ttgt            114


<210>  31
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  31

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  32
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  32
gctaaaggcc ttacttgggg actcggtgac aatgatgctc tcgatatc                    48


<210>  33
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala Leu Asp Ile 
1               5                   10                  15      


<210>  34
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  34
tggggccccg ggaccacggt caccgtctcc tca                                    33


<210>  35
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  35

Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  36
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  36
ggcggatcct ctaggtcaag ttccagcggc ggcggtggca gcggaggcgg cggt             54


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  37

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  38
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  38
gtacactggt accagcaggc tccaggaaca gcccccaaac tcctcatcta t                51


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  39

Val His Trp Tyr Gln Gln Ala Pro Gly Thr Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  40
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  40
gaaaacacc                                                                9


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  41

Glu Asn Thr 
1           


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  42
ttcggcggag ggaccaaggc caccgtccta                                        30


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  43

Phe Gly Gly Gly Thr Lys Ala Thr Val Leu 
1               5                   10  


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  44
ggattcaccc tcagtggcta tgct                                              24


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  45

Gly Phe Thr Leu Ser Gly Tyr Ala 
1               5               


<210>  46
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  46
tactacgcag actccgtgaa gggccgattc accgtctcca gagacaattc caagaacacg       60

ctgtttctgc aaatgaacag cctgagacct gaggacacgg ctgtgtacta ttgt            114


<210>  47
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  47

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  48
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  48
gctaaaggcc ttacttgggg actcggtgac aatgatgctc tcggtatc                    48


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  49

Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala Leu Gly Ile 
1               5                   10                  15      


<210>  50
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  50
tggggccccg agaccacggt caccgtctcc tca                                    33


<210>  51
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  51

Trp Gly Pro Glu Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  52
<211>  1419
<212>  DNA
<213>  Homo sapiens

<400>  52
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgtgag       60

gtgcagctgg tggagtctgg gggagccctg gccaagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac cctcagtggc tatgctatgc actgggtccg ccaggctcca      180

ggcaaggggc tggagtgggt ggcagttata tcatatgatg gaagcaataa atactacgca      240

gactccgtga agggccgatt caccgtctcc agagacaatt ccaagaacac gctgtttctg      300

caaatgaaca gcctgagacc tgaggacacg gctgtgtact attgtgctaa aggccttacc      360

tggggactcg gtgacaatga tgctctcgat atctggggcc ccgggaccac ggtcaccgtc      420

tcctcagcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      480

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      540

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      600

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      660

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      720

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaatga                            1419


<210>  53
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
        35                  40                  45              


Ser Gly Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala 
        115                 120                 125             


Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
    130                 135                 140                 


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
145                 150                 155                 160 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
                165                 170                 175     


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
            180                 185                 190         


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
        195                 200                 205             


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
    210                 215                 220                 


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
225                 230                 235                 240 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  54
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  54
atggagtttg ggctgagctg ggttttcctc gttgctcttt taagaggtgt ccagtgt          57


<210>  55
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Leu Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  56
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  56
gaggtgcagc tggtggagtc tgggggagcc ctggccaagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccctcagt ggctatgcta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa cacgctgttt      240

ctgcaaatga acagcctgag acctgaggac acggctgtgt actattgtgc taaaggcctt      300

acctggggac tcggtgacaa tgatgctctc gatatctggg gccccgggac cacggtcacc      360

gtctcctca                                                              369


<210>  57
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala Leu Asp Ile 
            100                 105                 110         


Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  58
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  58
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      360

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      540

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      600

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      960

cagaagagcc tctccctgtc tccgggtaaa                                       990


<210>  59
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  60
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  60
atggcctggt ctcctctcct cctcactctc ctcgctcact gcacagggtc ctgggcccag       60

tctgtgctga ctcagccgcc ctcagtgtct ggggccccag ggcagagtgt cattatctcc      120

tgcactggga gcagctccaa catcggggca ggttctcatg tacactggta ccagcaggtt      180

ccaggaacag cccccaaact cctcatctat gaaaacacca atcggccctc aggggtccct      240

gaccgattct ctggctccaa gtctggcacc tcaggttccc tggccatcac tggactccag      300

cctgaggatg aggctgatta ttattgtgca acatgggatg acagtctgaa tggtgtaata      360

ttcggcggag ggaccaaggc caccgtccta ggtcagccca aggctgcccc ctcggtcact      420

ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      480

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      540

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      600

tatctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      660

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttcatg a               711


<210>  61
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Trp Ser Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala 
            20                  25                  30          


Pro Gly Gln Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile 
        35                  40                  45              


Gly Ala Gly Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile 
                85                  90                  95      


Thr Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp 
            100                 105                 110         


Asp Asp Ser Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Ala Thr 
        115                 120                 125             


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
    130                 135                 140                 


Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
145                 150                 155                 160 


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
                165                 170                 175     


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
            180                 185                 190         


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
        195                 200                 205             


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
    210                 215                 220                 


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 235     


<210>  62
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  62
atggcctggt ctcctctcct cctcactctc ctcgctcact gcacagggtc ctgggcc          57


<210>  63
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Trp Ser Pro Leu Leu Leu Thr Leu Leu Ala His Cys Thr Gly 
1               5                   10                  15      


Ser Trp Ala 
            


<210>  64
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  64
cagtctgtgc tgactcagcc gccctcagtg tctggggccc cagggcagag tgtcattatc       60

tcctgcactg ggagcagctc caacatcggg gcaggttctc atgtacactg gtaccagcag      120

gttccaggaa cagcccccaa actcctcatc tatgaaaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcaggtt ccctggccat cactggactc      240

cagcctgagg atgaggctga ttattattgt gcaacatggg atgacagtct gaatggtgta      300

atattcggcg gagggaccaa ggccaccgtc cta                                   333


<210>  65
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  65

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Ala Thr Val Leu 
            100                 105                 110     


<210>  66
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  66
ggtcagccca aggctgcccc ctcggtcact ctgttcccgc cctcctctga ggagcttcaa       60

gccaacaagg ccacactggt gtgtctcata agtgacttct acccgggagc cgtgacagtg      120

gcctggaagg cagatagcag ccccgtcaag gcgggagtgg agaccaccac accctccaaa      180

caaagcaaca acaagtacgc ggccagcagc tatctgagcc tgacgcctga gcagtggaag      240

tcccacagaa gctacagctg ccaggtcacg catgaaggga gcaccgtgga gaagacagtg      300

gcccctacag aatgttca                                                    318


<210>  67
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  68
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala Leu Asp Ile 
            100                 105                 110         


Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  69
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  69

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser 
                85                  90                  95      


Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Ala Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  70
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  70
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  71
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  72
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  72
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  73
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  73

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  74
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  74
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  75
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  75

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  76
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  76
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  77
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  77

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  78
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  78
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  79
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  79

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  80
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  80
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccgtctagac agtctgtgct gactcagccg ccctcagtgt ctggggcccc agggcagagt      120

gtcattatct cctgcactgg gagcagctcc aacatcgggg caggttctca tgtacactgg      180

taccagcagg ttccaggaac agcccccaaa ctcctcatct atgaaaacac caatcggccc      240

tcaggggtcc ctgaccgatt ctctggctcc aagtctggca cctcaggttc cctggccatc      300

actggactcc agcctgagga tgaggctgat tattattgtg caacatggga tgacagtctg      360

aatggtgtaa tattcggcgg agggaccaag gccaccgtcc taggcggatc ctctaggtca      420

agttccagcg gcggcggtgg cagcggaggc ggcggtgagg tgcagctggt ggagtctggg      480

ggagccctgg ccaagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc      540

ctcagtggct atgctatgca ctgggtccgc caggctccag gcaaggggct ggagtgggtg      600

gcagttatat catatgatgg aagcaataaa tactacgcag actccgtgaa gggccgattc      660

accgtctcca gagacaattc caagaacacg ctgtttctgc aaatgaacag cctgagacct      720

gaggacacgg ctgtgtacta ttgtgctaaa ggccttacct ggggactcgg tgacaatgat      780

gctctcgata tctggggccc cgggaccacg gtcaccgtct cctcaagatc caccacgacg      840

ccagcgccgc gaccaccaac accggcgccc accatcgcgt cgcagcccct gtccctgcgc      900

ccagaggcgt gccggccagc ggcggggggc gcagtgcaca cgagggggct ggacttcgcc      960

tgtgatatct acatctgggc gcccttggcc gggacttgtg gggtccttct cctgtcactg     1020

gttatcaccc tttactgcaa acggggcaga aagaaactcc tgtatatatt caaacaacca     1080

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1140

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1200

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1260

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1320

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1380

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1440

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     1500

taa                                                                   1503


<210>  81
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  81

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Arg Gln Ser Val Leu Thr Gln Pro Pro Ser 
            20                  25                  30          


Val Ser Gly Ala Pro Gly Gln Ser Val Ile Ile Ser Cys Thr Gly Ser 
        35                  40                  45              


Ser Ser Asn Ile Gly Ala Gly Ser His Val His Trp Tyr Gln Gln Val 
    50                  55                  60                  


Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Gly 
                85                  90                  95      


Ser Leu Ala Ile Thr Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr 
            100                 105                 110         


Cys Ala Thr Trp Asp Asp Ser Leu Asn Gly Val Ile Phe Gly Gly Gly 
        115                 120                 125             


Thr Lys Ala Thr Val Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Ala Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Phe Thr Leu Ser Gly Tyr Ala Met His Trp Val Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser 
        195                 200                 205             


Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg 
    210                 215                 220                 


Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Gly Leu Thr Trp Gly Leu 
                245                 250                 255     


Gly Asp Asn Asp Ala Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr 
            260                 265                 270         


Val Ser Ser Arg Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro 
        275                 280                 285             


Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys 
    290                 295                 300                 


Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala 
305                 310                 315                 320 


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
                325                 330                 335     


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
            340                 345                 350         


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
        355                 360                 365             


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
    370                 375                 380                 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
385                 390                 395                 400 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
                405                 410                 415     


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
            420                 425                 430         


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
        435                 440                 445             


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
    450                 455                 460                 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
465                 470                 475                 480 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
                485                 490                 495     


Leu Pro Pro Arg 
            500 


<210>  82
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  82
caggtgcagc tgcagcagag cggcgcggaa ctggcgcgcc cgggcgcgag cgtgaaaatg       60

agctgcaaag cgagcggcta tacctttacc cgctatacca tgcattgggt gaaacagcgc      120

ccgggccagg gcctggaatg gattggctat attaacccga gccgcggcta taccaactat      180

aaccagaaat ttaaagataa agcgaccctg accaccgata aaagcagcag caccgcgtat      240

atgcagctga gcagcctgac cagcgaagat agcgcggtgt attattgcgc gcgctattat      300

gatgatcatt attgcctgga ttattggggc cagggcacca ccctgaccgt gagcagcggc      360

ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gccagattgt gctgacccag      420

agcccggcga ttatgagcgc gagcccgggc gaaaaagtga ccatgacctg cagcgcgagc      480

agcagcgtga gctatatgaa ctggtatcag cagaaaagcg gcaccagccc gaaacgctgg      540

atttatgata ccagcaaact ggcgagcggc gtgccggcgc attttcgcgg cagcggcagc      600

ggcaccagct atagcctgac cattagcggc atggaagcgg aagatgcggc gacctattat      660

tgccagcagt ggagcagcaa cccgtttacc tttggcagcg gcaccaaact ggaaattaac      720

cgc                                                                    723


<210>  83
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<400>  83

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
    130                 135                 140                 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
        195                 200                 205             


Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
225                 230                 235                 240 


Arg 
    


<210>  84
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  84
caggtgcagc tgcagcagag cggcgcggaa ctggcgcgcc cgggcgcgag cgtgaaaatg       60

agctgcaaag cgagcggcta tacctttacc cgctatacca tgcattgggt gaaacagcgc      120

ccgggccagg gcctggaatg gattggctat attaacccga gccgcggcta taccaactat      180

aaccagaaat ttaaagataa agcgaccctg accaccgata aaagcagcag caccgcgtat      240

atgcagctga gcagcctgac cagcgaagat agcgcggtgt attattgcgc gcgctattat      300

gatgatcatt attgcctgga ttattggggc cagggcacca ccctgaccgt gagcagc         357


<210>  85
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  85

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  86
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  86
cagattgtgc tgacccagag cccggcgatt atgagcgcga gcccgggcga aaaagtgacc       60

atgacctgca gcgcgagcag cagcgtgagc tatatgaact ggtatcagca gaaaagcggc      120

accagcccga aacgctggat ttatgatacc agcaaactgg cgagcggcgt gccggcgcat      180

tttcgcggca gcggcagcgg caccagctat agcctgacca ttagcggcat ggaagcggaa      240

gatgcggcga cctattattg ccagcagtgg agcagcaacc cgtttacctt tggcagcggc      300

accaaactgg aaattaaccg c                                                321


<210>  87
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  87

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn Arg 
            100                 105         


<210>  88
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  humanized scFv

<400>  88
caggtgcagc tggtgcagag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcaaag cgagcggcta tacctttacc cgctatacca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg gattggctat attaacccga gccgcggcta taccaactat      180

aaccagaaag tgaaagatcg ctttaccatt agcaccgata aaagcaaaag caccgcgttt      240

ctgcagatgg atagcctgcg cccggaagat accggcgtgt atttttgcgc gcgctattat      300

gatgatcatt attgcctgga ttattggggc cagggcacca ccctgaccgt gagcagcggc      360

ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gcgatattca gatgacccag      420

agcccgagca gcctgagcgc gagcgtgggc gatcgcgtga ccattacctg cagcgcgagc      480

agcagcgtga gctatatgaa ctggtatcag cagaccccgg gcaaagcgcc gaaacgctgg      540

atttatgata ccagcaaact ggcgagcggc gtgccgagcc gctttagcgg cagcggcagc      600

ggcaccgatt atacctttac cattagcagc ctgcagccgg aagatattgc gacctattat      660

tgccagcagt ggagcagcaa cccgtttacc tttggccagg gcaccaaact gcagattacc      720

cgc                                                                    723


<210>  89
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized scFv

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
145                 150                 155                 160 


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp 
    210                 215                 220                 


Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr 
225                 230                 235                 240 


Arg 
    


<210>  90
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  90
caggtgcagc tggtgcagag cggcggcggc gtggtgcagc cgggccgcag cctgcgcctg       60

agctgcaaag cgagcggcta tacctttacc cgctatacca tgcattgggt gcgccaggcg      120

ccgggcaaag gcctggaatg gattggctat attaacccga gccgcggcta taccaactat      180

aaccagaaag tgaaagatcg ctttaccatt agcaccgata aaagcaaaag caccgcgttt      240

ctgcagatgg atagcctgcg cccggaagat accggcgtgt atttttgcgc gcgctattat      300

gatgatcatt attgcctgga ttattggggc cagggcacca ccctgaccgt gagcagc         357


<210>  91
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  91

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser Lys Ser Thr Ala Phe 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  92
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  92
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgca gcgcgagcag cagcgtgagc tatatgaact ggtatcagca gaccccgggc      120

aaagcgccga aacgctggat ttatgatacc agcaaactgg cgagcggcgt gccgagccgc      180

tttagcggca gcggcagcgg caccgattat acctttacca ttagcagcct gcagccggaa      240

gatattgcga cctattattg ccagcagtgg agcagcaacc cgtttacctt tggccagggc      300

accaaactgc agattacccg c                                                321


<210>  93
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Gln Ile Thr Arg 
            100                 105         


<210>  94
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  94
gagcccaaat ctgctgacaa aactcacaca tgcccaccgt gccca                       45


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated IgG1 hinge amino acid sequence

<400>  95

Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  96
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated IgG4 Fc (N297A) nucleic acid sequence

<400>  96
gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact       60

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac      120

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag      180

ccgcgggagg agcagttcgc tagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      240

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc      300

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc      360

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa      420

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac      480

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta      540

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag      600

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa a               651


<210>  97
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated IgG4 Fc (N297A) amino acid sequence

<400>  97

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


<210>  98
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mutated IgG1 Hinge-IgG4 Fc nucleic acid sequence

<400>  98
gagcccaaat ctgctgacaa aactcacaca tgcccaccgt gcccagcacc tgagttcctg       60

gggggaccat cagtcttcct gttcccccca aaacccaagg acactctcat gatctcccgg      120

acccctgagg tcacgtgcgt ggtggtggac gtgagccagg aagaccccga ggtccagttc      180

aactggtacg tggatggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      240

ttcgctagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaac      300

ggcaaggagt acaagtgcaa ggtctccaac aaaggcctcc cgtcctccat cgagaaaacc      360

atctccaaag ccaaagggca gccccgagag ccacaggtgt acaccctgcc cccatcccag      420

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctaccccagc      480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      540

cccgtgctgg actccgacgg ctccttcttc ctctacagca ggctaaccgt ggacaagagc      600

aggtggcagg aggggaatgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac      660

tacacacaga agagcctctc cctgtctctg ggtaaa                                696


<210>  99
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated IgG1 Hinge-IgG4 Fc amino acid sequence

<400>  99

Glu Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230         


<210>  100
<211>  1547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv1 MCS-G4S-hOKT3 scFv-IgG1 hinge - IgG4 Fc expression cassette
       nucleic acid sequence

<400>  100
actagtgcca ccatggagtt tgggctgagc tgggtcttcc tggtggctat cttgaagggt       60

gtccagtgtg aattcaagct ttctagaagc gctgctagcg gtggaggtgg atcccaggtc      120

cagctggtgc agtcaggggg gggagtcgtg cagcccggtc ggtctctgcg tctgtcttgt      180

aaggcatccg gttatacttt taccaggtac acaatgcact gggtgcggca ggctcctggc      240

aagggcctgg agtggatcgg ctatatcaac ccatccaggg gctacaccaa ctataatcag      300

aaggtgaagg accggttcac catctctaca gataagagca agtctacagc ctttctgcag      360

atggactccc tgagacctga ggataccggc gtgtacttct gcgctcgcta ctatgacgat      420

cattactgtc tggactattg gggccagggc accacactga cagtgtccag cggaggagga      480

ggctccggag gaggaggcag cggcggcggc ggctctgaca tccagatgac ccagagccca      540

tcttccctgt ccgccagcgt gggcgataga gtgaccatca catgctccgc ctcctcctcc      600

gtgtcctaca tgaactggta tcagcagaca cccggcaagg cccctaagag atggatctac      660

gatacctcca agctggcctc cggagtgccc tctcgcttct ctggctccgg cagcggcaca      720

gactatacct ttacaatcag ctctctgcag cctgaggata tcgctaccta ctattgtcag      780

cagtggtcca gcaatccatt cacctttggc cagggcacaa agctgcagat caccaggctc      840

gagccaaaga gcgccgacaa gacccacaca tgcccccctt gtccagctcc cgagtttctg      900

ggcggcccat ccgtgttcct gtttccaccc aagcccaagg atacactgat gatcagccgg      960

accccagagg tgacatgcgt ggtggtggac gtgtctcagg aggaccccga ggtgcagttc     1020

aactggtacg tggacggcgt ggaggtgcac aatgccaaga ccaagcccag ggaggagcag     1080

tttgcttcta cataccgggt ggtgtccgtg ctgaccgtgc tgcatcagga ttggctgaac     1140

ggcaaggagt ataagtgcaa ggtgtccaat aagggcctgc cttcttccat cgagaagaca     1200

atcagcaagg ctaagggaca gcctcgcgag ccacaggtgt acaccctgcc tccatctcag     1260

gaggagatga caaagaacca ggtgtccctg acctgtctgg tgaagggctt ctatccctcc     1320

gacatcgctg tggagtggga gagcaatggc cagcctgaga acaattacaa gaccacaccc     1380

cctgtgctgg acagcgatgg ctctttcttt ctgtatagca gactgaccgt ggataagtct     1440

cgctggcagg agggcaacgt gttctcctgt tccgtgatgc acgaggcact gcacaaccac     1500

tacactcaga aatcactgtc actgtccctg ggcaagtagg cggccgc                   1547


<210>  101
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv1 MCS-G4S-hOKT3 scFv-IgG1 hinge - IgG4 Fc expression cassette
       amino acid sequence

<400>  101

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Met Cys Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
65                  70                  75                  80  


Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys 
                85                  90                  95      


Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp 
            100                 105                 110         


Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            180                 185                 190         


Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Lys Leu Gln Ile Thr Arg Leu Glu Pro Lys Ser Ala Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
305                 310                 315                 320 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                485                 490                 495     


<210>  102
<211>  1547
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv1 MCS-G4S-mOKT3 scFv-IgG1 hinge - IgG4 Fc expression cassette
       nucleic acid sequence

<400>  102
actagtgcca ccatggagtt tgggctgagc tgggtcttcc tggtggctat cttgaagggt       60

gtccagtgtg aattcaagct ttctagaagc gctgctagcg gtggaggtgg atcccaggtc      120

cagctgcagc agagcggtgc cgaactggcc cgtcccggag caagcgtgaa aatgtcctgt      180

aaagcaagtg gctatacctt caccaggtac acaatgcact gggtgaagca gaggccagga      240

cagggcctgg agtggatcgg ctatatcaac ccctctaggg gctacacaaa ctataatcag      300

aagttcaagg acaaggccac cctgaccacc gataagtcca gctctacagc ttacatgcag      360

ctgtccagcc tgaccagcga ggactctgcc gtgtactatt gcgctagata ctatgacgat      420

cattactgtc tggattattg gggccagggc accacactga cagtgtcttc cggaggagga      480

ggcagcggag gaggaggctc tggcggcggc ggctcccaga tcgtgctgac ccagtcccca      540

gctatcatgt ccgcctcccc tggagagaag gtgaccatga catgcagcgc cagctcttcc      600

gtgtcttaca tgaattggta tcagcagaag tccggcacaa gccctaagag atggatctac      660

gacacctcta agctggcctc cggagtgcca gctcactttc gcggctccgg cagcggcacc      720

tcttattccc tgacaatcag cggcatggag gctgaggatg ccgctaccta ctattgtcag      780

cagtggtcat caaatccttt caccttcggt tcagggacaa aactggagat caataggctc      840

gagccaaaga gcgccgacaa gacccacaca tgcccccctt gtccagctcc cgagtttctg      900

ggcggcccat ccgtgttcct gtttccaccc aagcccaagg atacactgat gatcagccgg      960

accccagagg tgacatgcgt ggtggtggac gtgtctcagg aggaccccga ggtgcagttc     1020

aactggtacg tggacggcgt ggaggtgcac aatgccaaga ccaagcccag ggaggagcag     1080

tttgcttcta cataccgggt ggtgtccgtg ctgaccgtgc tgcatcagga ttggctgaac     1140

ggcaaggagt ataagtgcaa ggtgtccaat aagggcctgc cttcttccat cgagaagaca     1200

atcagcaagg ctaagggaca gcctcgcgag ccacaggtgt acaccctgcc tccatctcag     1260

gaggagatga caaagaacca ggtgtccctg acctgtctgg tgaagggctt ctatccctcc     1320

gacatcgctg tggagtggga gagcaatggc cagcctgaga acaattacaa gaccacaccc     1380

cctgtgctgg acagcgatgg ctctttcttt ctgtatagca gactgaccgt ggataagtct     1440

cgctggcagg agggcaacgt gttctcctgt tccgtgatgc acgaggcact gcacaaccac     1500

tacactcaga aatcactgtc actgtccctg ggcaagtagg cggccgc                   1547


<210>  103
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv1 MCS-G4S-mOKT3 scFv-IgG1 hinge - IgG4 Fc expression cassette
       amino acid sequence

<400>  103

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Met Cys Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr 
65                  70                  75                  80  


Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys 
                85                  90                  95      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu 
145                 150                 155                 160 


Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr 
                165                 170                 175     


Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys 
        195                 200                 205             


Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr 
225                 230                 235                 240 


Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Asn Arg Leu Glu Pro Lys Ser Ala Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
305                 310                 315                 320 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                485                 490                 495     


<210>  104
<211>  2265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-PSMA & hOKT3 bispecific Ab nucleic acid sequence (gy1-2)

<400>  104
atggagtttg ggctgagctg ggtcttcctg gtggctatct tgaagggtgt ccagtgtgaa       60

ttccagtctg tgctgactca gccgccctca gtgtctgggg ccccagggca gagtgtcatt      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt ctcatgtaca ctggtaccag      180

caggttccag gaacagcccc caaactcctc atctatgaaa acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag gttccctggc catcactgga      300

ctccagcctg aggatgaggc tgattattat tgtgcaacat gggatgacag tctgaatggt      360

gtaatattcg gcggagggac caaggccacc gtcctaggcg gatcctctag gtcaagttcc      420

agcggcggcg gtggcagcgg aggcggcggt gaggtgcagc tggtggagtc tgggggagcc      480

ctggccaagc ctggggggtc cctgagactc tcctgtgcag cctctggatt caccctcagt      540

ggctatgcta tgcactgggt ccgccaggct ccaggcaagg ggctggagtg ggtggcagtt      600

atatcatatg atggaagcaa taaatactac gcagactccg tgaagggccg attcaccgtc      660

tccagagaca attccaagaa cacgctgttt ctgcaaatga acagcctgag acctgaggac      720

acggctgtgt actattgtgc taaaggcctt acctggggac tcggtgacaa tgatgctctc      780

gatatctggg gccccgggac cacggtcacc gtctcctcag ctagcggtgg aggtggatcc      840

caggtccagc tggtgcagtc agggggggga gtcgtgcagc ccggtcggtc tctgcgtctg      900

tcttgtaagg catccggtta tacttttacc aggtacacaa tgcactgggt gcggcaggct      960

cctggcaagg gcctggagtg gatcggctat atcaacccat ccaggggcta caccaactat     1020

aatcagaagg tgaaggaccg gttcaccatc tctacagata agagcaagtc tacagccttt     1080

ctgcagatgg actccctgag acctgaggat accggcgtgt acttctgcgc tcgctactat     1140

gacgatcatt actgtctgga ctattggggc cagggcacca cactgacagt gtccagcgga     1200

ggaggaggct ccggaggagg aggcagcggc ggcggcggct ctgacatcca gatgacccag     1260

agcccatctt ccctgtccgc cagcgtgggc gatagagtga ccatcacatg ctccgcctcc     1320

tcctccgtgt cctacatgaa ctggtatcag cagacacccg gcaaggcccc taagagatgg     1380

atctacgata cctccaagct ggcctccgga gtgccctctc gcttctctgg ctccggcagc     1440

ggcacagact atacctttac aatcagctct ctgcagcctg aggatatcgc tacctactat     1500

tgtcagcagt ggtccagcaa tccattcacc tttggccagg gcacaaagct gcagatcacc     1560

aggctcgagc caaagagcgc cgacaagacc cacacatgcc ccccttgtcc agctcccgag     1620

tttctgggcg gcccatccgt gttcctgttt ccacccaagc ccaaggatac actgatgatc     1680

agccggaccc cagaggtgac atgcgtggtg gtggacgtgt ctcaggagga ccccgaggtg     1740

cagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag     1800

gagcagtttg cttctacata ccgggtggtg tccgtgctga ccgtgctgca tcaggattgg     1860

ctgaacggca aggagtataa gtgcaaggtg tccaataagg gcctgccttc ttccatcgag     1920

aagacaatca gcaaggctaa gggacagcct cgcgagccac aggtgtacac cctgcctcca     1980

tctcaggagg agatgacaaa gaaccaggtg tccctgacct gtctggtgaa gggcttctat     2040

ccctccgaca tcgctgtgga gtgggagagc aatggccagc ctgagaacaa ttacaagacc     2100

acaccccctg tgctggacag cgatggctct ttctttctgt atagcagact gaccgtggat     2160

aagtctcgct ggcaggaggg caacgtgttc tcctgttccg tgatgcacga ggcactgcac     2220

aaccactaca ctcagaaatc actgtcactg tccctgggca agtag                     2265


<210>  105
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA & hOKT3 bispecific Ab amino acid sequence (gy1-2)

<400>  105

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Phe Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Ser His Val His Trp Tyr Gln Gln Val Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            100                 105                 110         


Thr Trp Asp Asp Ser Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Ala Thr Val Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Ala 
145                 150                 155                 160 


Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Phe Thr Leu Ser Gly Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
        195                 200                 205             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp 
                245                 250                 255     


Asn Asp Ala Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser 
            260                 265                 270         


Ser Ala Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly 
        275                 280                 285             


Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala 
    290                 295                 300                 


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala 
305                 310                 315                 320 


Pro Gly Lys Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
                325                 330                 335     


Tyr Thr Asn Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr 
            340                 345                 350         


Asp Lys Ser Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro 
        355                 360                 365             


Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
    370                 375                 380                 


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
                405                 410                 415     


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            420                 425                 430         


Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
        435                 440                 445             


Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr 
    450                 455                 460                 


Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
            500                 505                 510         


Gln Gly Thr Lys Leu Gln Ile Thr Arg Leu Glu Pro Lys Ser Ala Asp 
        515                 520                 525             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
    530                 535                 540                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
545                 550                 555                 560 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
                565                 570                 575     


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            580                 585                 590         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg 
        595                 600                 605             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    610                 615                 620                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
625                 630                 635                 640 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                645                 650                 655     


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            660                 665                 670         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        675                 680                 685             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    690                 695                 700                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
                725                 730                 735     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
            740                 745                 750         


Gly Lys 
        


<210>  106
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA & hOKT3 bispecific Ab amino acid sequence (gy1-2) 
       without signal peptide

<400>  106

Glu Phe Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro 
1               5                   10                  15      


Gly Gln Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Ala Gly Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr 
65                  70                  75                  80  


Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp 
                85                  90                  95      


Asp Ser Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Ala Thr Val 
            100                 105                 110         


Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
145                 150                 155                 160 


Ser Gly Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala 
225                 230                 235                 240 


Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val 
            260                 265                 270         


Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Tyr 
        275                 280                 285             


Thr Phe Thr Arg Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
305                 310                 315                 320 


Tyr Asn Gln Lys Val Lys Asp Arg Phe Thr Ile Ser Thr Asp Lys Ser 
                325                 330                 335     


Lys Ser Thr Ala Phe Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr 
            340                 345                 350         


Gly Val Tyr Phe Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            420                 425                 430         


Thr Pro Gly Lys Ala Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    450                 455                 460                 


Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Gln Gly Thr 
                485                 490                 495     


Lys Leu Gln Ile Thr Arg Leu Glu Pro Lys Ser Ala Asp Lys Thr His 
            500                 505                 510         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        515                 520                 525             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    530                 535                 540                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
545                 550                 555                 560 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                565                 570                 575     


Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser 
            580                 585                 590         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        595                 600                 605             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    610                 615                 620                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
625                 630                 635                 640 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                645                 650                 655     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            660                 665                 670         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        675                 680                 685             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    690                 695                 700                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
705                 710                 715                 720 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                725                 730                 735 


<210>  107
<211>  2265
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-PSMA & mOKT3 bispecific Ab nucleic acid sequence (gy1-2)

<400>  107
atggagtttg ggctgagctg ggtcttcctg gtggctatct tgaagggtgt ccagtgtgaa       60

ttccagtctg tgctgactca gccgccctca gtgtctgggg ccccagggca gagtgtcatt      120

atctcctgca ctgggagcag ctccaacatc ggggcaggtt ctcatgtaca ctggtaccag      180

caggttccag gaacagcccc caaactcctc atctatgaaa acaccaatcg gccctcaggg      240

gtccctgacc gattctctgg ctccaagtct ggcacctcag gttccctggc catcactgga      300

ctccagcctg aggatgaggc tgattattat tgtgcaacat gggatgacag tctgaatggt      360

gtaatattcg gcggagggac caaggccacc gtcctaggcg gatcctctag gtcaagttcc      420

agcggcggcg gtggcagcgg aggcggcggt gaggtgcagc tggtggagtc tgggggagcc      480

ctggccaagc ctggggggtc cctgagactc tcctgtgcag cctctggatt caccctcagt      540

ggctatgcta tgcactgggt ccgccaggct ccaggcaagg ggctggagtg ggtggcagtt      600

atatcatatg atggaagcaa taaatactac gcagactccg tgaagggccg attcaccgtc      660

tccagagaca attccaagaa cacgctgttt ctgcaaatga acagcctgag acctgaggac      720

acggctgtgt actattgtgc taaaggcctt acctggggac tcggtgacaa tgatgctctc      780

gatatctggg gccccgggac cacggtcacc gtctcctcag ctagcggtgg aggtggatcc      840

caggtccagc tgcagcagag cggtgccgaa ctggcccgtc ccggagcaag cgtgaaaatg      900

tcctgtaaag caagtggcta taccttcacc aggtacacaa tgcactgggt gaagcagagg      960

ccaggacagg gcctggagtg gatcggctat atcaacccct ctaggggcta cacaaactat     1020

aatcagaagt tcaaggacaa ggccaccctg accaccgata agtccagctc tacagcttac     1080

atgcagctgt ccagcctgac cagcgaggac tctgccgtgt actattgcgc tagatactat     1140

gacgatcatt actgtctgga ttattggggc cagggcacca cactgacagt gtcttccgga     1200

ggaggaggca gcggaggagg aggctctggc ggcggcggct cccagatcgt gctgacccag     1260

tccccagcta tcatgtccgc ctcccctgga gagaaggtga ccatgacatg cagcgccagc     1320

tcttccgtgt cttacatgaa ttggtatcag cagaagtccg gcacaagccc taagagatgg     1380

atctacgaca cctctaagct ggcctccgga gtgccagctc actttcgcgg ctccggcagc     1440

ggcacctctt attccctgac aatcagcggc atggaggctg aggatgccgc tacctactat     1500

tgtcagcagt ggtcatcaaa tcctttcacc ttcggttcag ggacaaaact ggagatcaat     1560

aggctcgagc caaagagcgc cgacaagacc cacacatgcc ccccttgtcc agctcccgag     1620

tttctgggcg gcccatccgt gttcctgttt ccacccaagc ccaaggatac actgatgatc     1680

agccggaccc cagaggtgac atgcgtggtg gtggacgtgt ctcaggagga ccccgaggtg     1740

cagttcaact ggtacgtgga cggcgtggag gtgcacaatg ccaagaccaa gcccagggag     1800

gagcagtttg cttctacata ccgggtggtg tccgtgctga ccgtgctgca tcaggattgg     1860

ctgaacggca aggagtataa gtgcaaggtg tccaataagg gcctgccttc ttccatcgag     1920

aagacaatca gcaaggctaa gggacagcct cgcgagccac aggtgtacac cctgcctcca     1980

tctcaggagg agatgacaaa gaaccaggtg tccctgacct gtctggtgaa gggcttctat     2040

ccctccgaca tcgctgtgga gtgggagagc aatggccagc ctgagaacaa ttacaagacc     2100

acaccccctg tgctggacag cgatggctct ttctttctgt atagcagact gaccgtggat     2160

aagtctcgct ggcaggaggg caacgtgttc tcctgttccg tgatgcacga ggcactgcac     2220

aaccactaca ctcagaaatc actgtcactg tccctgggca agtag                     2265


<210>  108
<211>  754
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA & mOKT3 bispecific Ab amino acid sequence (gy1-2)

<400>  108

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Phe Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser 
            20                  25                  30          


Gly Ala Pro Gly Gln Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser 
        35                  40                  45              


Asn Ile Gly Ala Gly Ser His Val His Trp Tyr Gln Gln Val Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu 
                85                  90                  95      


Ala Ile Thr Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            100                 105                 110         


Thr Trp Asp Asp Ser Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Ala Thr Val Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Ala 
145                 150                 155                 160 


Leu Ala Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Phe Thr Leu Ser Gly Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys 
        195                 200                 205             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn 
    210                 215                 220                 


Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp 
                245                 250                 255     


Asn Asp Ala Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser 
            260                 265                 270         


Ser Ala Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly 
        275                 280                 285             


Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala 
    290                 295                 300                 


Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg 
305                 310                 315                 320 


Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly 
                325                 330                 335     


Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr 
            340                 345                 350         


Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
        355                 360                 365             


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr 
    370                 375                 380                 


Cys Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile 
                405                 410                 415     


Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys 
            420                 425                 430         


Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp 
        435                 440                 445             


Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr 
    450                 455                 460                 


Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser 
465                 470                 475                 480 


Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala 
                485                 490                 495     


Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly 
            500                 505                 510         


Ser Gly Thr Lys Leu Glu Ile Asn Arg Leu Glu Pro Lys Ser Ala Asp 
        515                 520                 525             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
    530                 535                 540                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
545                 550                 555                 560 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
                565                 570                 575     


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            580                 585                 590         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg 
        595                 600                 605             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    610                 615                 620                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
625                 630                 635                 640 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                645                 650                 655     


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            660                 665                 670         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        675                 680                 685             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    690                 695                 700                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
705                 710                 715                 720 


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
                725                 730                 735     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
            740                 745                 750         


Gly Lys 
        


<210>  109
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-PSMA & mOKT3 bispecific Ab amino acid sequence (gy1-2)

<400>  109

Glu Phe Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro 
1               5                   10                  15      


Gly Gln Ser Val Ile Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly 
            20                  25                  30          


Ala Gly Ser His Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Glu Asn Thr Asn Arg Pro Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr 
65                  70                  75                  80  


Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp 
                85                  90                  95      


Asp Ser Leu Asn Gly Val Ile Phe Gly Gly Gly Thr Lys Ala Thr Val 
            100                 105                 110         


Leu Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Ala Lys 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu 
145                 150                 155                 160 


Ser Gly Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                165                 170                 175     


Glu Trp Val Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys Gly Leu Thr Trp Gly Leu Gly Asp Asn Asp Ala 
225                 230                 235                 240 


Leu Asp Ile Trp Gly Pro Gly Thr Thr Val Thr Val Ser Ser Ala Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu 
            260                 265                 270         


Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr 
        275                 280                 285             


Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln Arg Pro Gly Gln 
    290                 295                 300                 


Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn 
305                 310                 315                 320 


Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser 
                325                 330                 335     


Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp 
        355                 360                 365             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
                405                 410                 415     


Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln 
            420                 425                 430         


Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        435                 440                 445             


Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser 
    450                 455                 460                 


Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr 
465                 470                 475                 480 


Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr 
                485                 490                 495     


Lys Leu Glu Ile Asn Arg Leu Glu Pro Lys Ser Ala Asp Lys Thr His 
            500                 505                 510         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
        515                 520                 525             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    530                 535                 540                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
545                 550                 555                 560 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                565                 570                 575     


Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Tyr Arg Val Val Ser 
            580                 585                 590         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        595                 600                 605             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    610                 615                 620                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
625                 630                 635                 640 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                645                 650                 655     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            660                 665                 670         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        675                 680                 685             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    690                 695                 700                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
705                 710                 715                 720 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                725                 730                 735 


<210>  110
<211>  1184
<212>  DNA
<213>  Homo sapiens

<400>  110
cgtgaggctc cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt       60

tggggggagg ggtcggcaat tgaaccggtg cctagagaag gtggcgcggg gtaaactggg      120

aaagtgatgt cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa      180

gtgcagtagt cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacaggtaa      240

gtgccgtgtg tggttcccgc gggcctggcc tctttacggg ttatggccct tgcgtgcctt      300

gaattacttc cacctggctg cagtacgtga ttcttgatcc cgagcttcgg gttggaagtg      360

ggtgggagag ttcgaggcct tgcgcttaag gagccccttc gcctcgtgct tgagttgagg      420

cctggcctgg gcgctggggc cgccgcgtgc gaatctggtg gcaccttcgc gcctgtctcg      480

ctgctttcga taagtctcta gccatttaaa atttttgatg acctgctgcg acgctttttt      540

tctggcaaga tagtcttgta aatgcgggcc aagatctgca cactggtatt tcggtttttg      600

gggccgcggg cggcgacggg gcccgtgcgt cccagcgcac atgttcggcg aggcggggcc      660

tgcgagcgcg gccaccgaga atcggacggg ggtagtctca agctggccgg cctgctctgg      720

tgcctggcct cgcgccgccg tgtatcgccc cgccctgggc ggcaaggctg gcccggtcgg      780

caccagttgc gtgagcggaa agatggccgc ttcccggccc tgctgcaggg agctcaaaat      840

ggaggacgcg gcgctcggga gagcgggcgg gtgagtcacc cacacaaagg aaaagggcct      900

ttccgtcctc agccgtcgct tcatgtgact ccacggagta ccgggcgccg tccaggcacc      960

tcgattagtt ctcgagcttt tggagtacgt cgtctttagg ttggggggag gggttttatg     1020

cgatggagtt tccccacact gagtgggtgg agactgaagt taggccagct tggcacttga     1080

tgtaattctc cttggaattt gccctttttg agtttggatc ttggttcatt ctcaagcctc     1140

agacagtggt tcaaagtttt tttcttccat ttcaggtgtc gtga                      1184


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  111
gactacaagg acgacgatga c                                                 21


<210>  112
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  112
agtagaatca agacctagta gaggg                                             25


<210>  113
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  113
ctattgccag cattgctgc                                                    19


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  114
atagggacct agacttcagg                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  115
ccttctactc ctcctacacc                                                   20


<210>  116
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  116
ggagggcgtg aatgtaagc                                                    19


