                         SEQUENCE LISTING

<110>  Genentech, Inc.
       F. Hoffmann-La Roche AG
 
<120>  METHODS FOR MONITORING AND TREATING CANCER

<130>  50474-128WO2

<150>  US 62/323,280
<151>  2016-04-15

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1975
<212>  RNA
<213>  Homo sapiens

<400>  1
acuuuccccc cucggcgccc caccggcucc cgcgcgccuc cccucgcgcc cgagcuucga       60

gccaagcagc guccugggga gcgcgucaug gccuuaccag ugaccgccuu gcuccugccg      120

cuggccuugc ugcuccacgc cgccaggccg agccaguucc gggugucgcc gcuggaucgg      180

accuggaacc ugggcgagac aguggagcug aagugccagg ugcugcuguc caacccgacg      240

ucgggcugcu cguggcucuu ccagccgcgc ggcgccgccg ccagucccac cuuccuccua      300

uaccucuccc aaaacaagcc caaggcggcc gaggggcugg acacccagcg guucucgggc      360

aagagguugg gggacaccuu cguccucacc cugagcgacu uccgccgaga gaacgagggc      420

uacuauuucu gcucggcccu gagcaacucc aucauguacu ucagccacuu cgugccgguc      480

uuccugccag cgaagcccac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      540

aucgcgucgc agccccuguc ccugcgccca gaggcgugcc ggccagcggc ggggggcgca      600

gugcacacga gggggcugga cuucgccugu gauaucuaca ucugggcgcc ccuggccggg      660

acuugugggg uccuucuccu gucacugguu aucacccuuu acugcaacca caggaaccga      720

agacguguuu gcaaaugucc ccggccugug gucaaaucgg gagacaagcc cagccuuucg      780

gcgagauacg ucuaacccug ugcaacagcc acuacauuac uucaaacuga gauccuuccu      840

uuugagggag caaguccuuc ccuuucauuu uuuccagucu uccucccugu guauucauuu      900

ucaugauuau uauuuuagug ggggcggggu gggaaagauu acuuuuucuu uauguguuug      960

acgggaaaca aaacuaggua aaaucuacag uacaccacaa gggucacaau acuguugugc     1020

gcacaucgcg guagggcgug gaaaggggca ggccagagcu acccgcagag uucucagaau     1080

caugcugaga gagcuggagg cacccaugcc aucucaaccu cuuccccgcc cguuuuacaa     1140

agggggaggc uaaagcccag agacagcuug aucaaaggca cacagcaagu caggguugga     1200

gcaguagcug gagggaccuu gucucccagc ucagggcucu uuccuccaca ccauucaggu     1260

cuuucuuucc gaggccccug ucucagggug aggugcuuga gucuccaacg gcaagggaac     1320

aaguacuucu ugauaccugg gauacugugc ccagagccuc gaggagguaa ugaauuaaag     1380

aagagaacug ccuuuggcag aguucuauaa uguaaacaau aucagacuuu uuuuuuuuau     1440

aaucaagccu aaaauuguau agaccuaaaa uaaaaugaag uggugagcuu aacccuggaa     1500

aaugaauccc ucuaucucua aagaaaaucu cugugaaacc ccuacgugga ggcggaauug     1560

cucucccagc ccuugcauug cagaggggcc caugaaagag gacaggcuac cccuuuacaa     1620

auagaauuug agcaucagug agguuaaacu aaggcccucu ugaaucucug aauuugagau     1680

acaaacaugu uccugggauc acugaugacu uuuuauacuu uguaaagaca auuguuggag     1740

agccccucac acagcccugg ccuccgcuca acuagcagau acagggauga ggcagaccug     1800

acucucuuaa ggaggcugag agcccaaacu gcugucccaa acaugcacuu ccuugcuuaa     1860

gguaugguac aagcaaugcc ugcccauugg agagaaaaaa cuuaaguaga uaaggaaaua     1920

agaaccacuc auaauucuuc accuuaggaa uaaucuccug uuaauauggu guaca          1975


<210>  2
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  3
<211>  1411
<212>  RNA
<213>  Homo sapiens

<400>  3
gcgacugucu ccgccgagcc cccggggcca ggugucccgg gcgcgccacg augcggccgc       60

ggcuguggcu ccuccuggcc gcgcagcuga caguucucca uggcaacuca guccuccagc      120

agaccccugc auacauaaag gugcaaacca acaagauggu gaugcugucc ugcgaggcua      180

aaaucucccu caguaacaug cgcaucuacu ggcugagaca gcgccaggca ccgagcagug      240

acagucacca cgaguuccug gcccucuggg auuccgcaaa agggacuauc cacggugaag      300

agguggaaca ggagaagaua gcuguguuuc gggaugcaag ccgguucauu cucaaucuca      360

caagcgugaa gccggaagac aguggcaucu acuucugcau gaucgucggg agccccgagc      420

ugaccuucgg gaagggaacu cagcugagug ugguugauuu ccuucccacc acugcccagc      480

ccaccaagaa guccacccuc aagaagagag ugugccgguu acccaggcca gagacccaga      540

agggcccacu uuguagcccc aucacccuug gccugcuggu ggcuggcguc cugguucugc      600

ugguuucccu gggaguggcc auccaccugu gcugccggcg gaggagagcc cggcuucguu      660

ucaugaaaca auuuuacaaa uaagcagaga auacgguuuu gguguccugc uacaaaaaga      720

caucggucag uaaugagcac gauguggaaa aaugagagaa gggacacauu caacccugga      780

gaguucaaug gcugcugaag cugccugcuu uucacugcug caaggccuuu cuguguguga      840

ugugcauggg agcaacuugu ucguggguca ucgggaauac uagggagaag guuucauugc      900

ccccagggca cuucacagag ugugcuggag gacugaguaa gaaaugcugc ccaugccacc      960

gcuuccggcu ccugugcuuu cccugaacug ggaccuuuag ugguggccau uuagccacca     1020

ucuuugcagg uugcuuugcc cugguagggc aguaacauug gguccugggu cuuucauggg     1080

gugaugcugg gcuggcuccc ucuuggucuu cccaggcugg ggcugaccuu ccucgcagag     1140

aggccaggug cagguuggga augaggcuug cugagagggg cuguccaguu cccagaaggc     1200

auaucagucu cugagggcuu ccuuuggggc cgggaacuug cggguuugag gauaggaguu     1260

cacuucaucu ucucagcucc cauuucuacu cuuaaguuuc uccccauuuc uacucuuaag     1320

uuucucagcu cccauuucua cucucccaug gcuucaugcu ucuuucauuu uucuguuugu     1380

uuuauacaaa uguguuaguu guacaaauaa a                                    1411


<210>  4
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Arg Leu Trp Leu Leu Leu Ala Ala Gln Leu Thr Val Leu 
1               5                   10                  15      


His Gly Asn Ser Val Leu Gln Gln Thr Pro Ala Tyr Ile Lys Val Gln 
            20                  25                  30          


Thr Asn Lys Met Val Met Leu Ser Cys Glu Ala Lys Ile Ser Leu Ser 
        35                  40                  45              


Asn Met Arg Ile Tyr Trp Leu Arg Gln Arg Gln Ala Pro Ser Ser Asp 
    50                  55                  60                  


Ser His His Glu Phe Leu Ala Leu Trp Asp Ser Ala Lys Gly Thr Ile 
65                  70                  75                  80  


His Gly Glu Glu Val Glu Gln Glu Lys Ile Ala Val Phe Arg Asp Ala 
                85                  90                  95      


Ser Arg Phe Ile Leu Asn Leu Thr Ser Val Lys Pro Glu Asp Ser Gly 
            100                 105                 110         


Ile Tyr Phe Cys Met Ile Val Gly Ser Pro Glu Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr Gln Leu Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro 
    130                 135                 140                 


Thr Lys Lys Ser Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro 
145                 150                 155                 160 


Glu Thr Gln Lys Gly Pro Leu Cys Ser Pro Ile Thr Leu Gly Leu Leu 
                165                 170                 175     


Val Ala Gly Val Leu Val Leu Leu Val Ser Leu Gly Val Ala Ile His 
            180                 185                 190         


Leu Cys Cys Arg Arg Arg Arg Ala Arg Leu Arg Phe Met Lys Gln Phe 
        195                 200                 205             


Tyr Lys 
    210 


<210>  5
<211>  2061
<212>  RNA
<213>  Homo sapiens

<400>  5
augcaguugg gagagcagcu cuuggugagc ucagugaacc ugccuggcgc gcacuucuac       60

ccgcuggaga gugcgcgagg cggcagcggc gggagcgcug gccaccuccc cagcgcggcc      120

cccucuccuc agaaguugga cuuaggcaaa gcguccaaga aguuuuccgg cagucucucc      180

ugcgaggcgg ugagcgggga gccugcagcc gccagcgcag gggcccccgc ggccaugcuu      240

agugacaccg acgccgggga cgcauuugcc agcgcugcgg caguggccaa gccggggccc      300

ccggacggcc gcaagggcuc ccccugcggg gaggaggagc ugcccuccgc cgcugcagcc      360

gccgccgccg ccgccgccgc ggcugcggcc acugcgcgcu acuccaugga cagccugagc      420

uccgugcggu acuaccucca gucccccggu ccucaggggu cggagcuggc ugcgcccugc      480

ucacucuucc cguaccaggc ggcggcuggg gcgccccacg gaccugugua cccggcuccu      540

aacggggcgc gcuaccccua cggcuccaug cugccccccg gcggcuuccc cgcggcugcg      600

ugcccacccg ggagggcgca guucggccca ggagccggug cgggcagugg cgcgggcggu      660

aucaacggcg ggggcggcgg cccgggcacc uaucaguaca gccagggggc uccgcucuac      720

gggccguacc cuggagccgc agcggcggga ucuugcggag gacugggggg ccuggggguu      780

ccaaguucug gcuuccgugc ccacgucuac cugugcaacc ggccucugug gcucaaauuc      840

caccggcacc aaacugagau gaucaucacc aaacagggca ggcgcauguu uccuuucuug      900

agcuucaaca uaaacggacu caaccccacc gcccacuaca auguuuucgu ggaagugguu      960

cuggccgacc cuaaccacug gcgcuuccag gggggcaaau gggugaccug uggcaaagcc     1020

gacaauaaca ugcagggcaa caaaauguau guucacccag agucuccuaa uacugguucc     1080

cacuggauga gacaggagau uucauucggg aaauuaaaac ucaccaauaa caaaggcgca     1140

aauaacaaca acacccagau gauagucuua caauccuuac acaaauacca accccgacug     1200

cauauuguug aaguuacaga ggauggcgug gaggacuuga augagcccuc aaagacccag     1260

acuuuuaccu ucucagaaac gcaauucauu gcagugacug ccuaccaaaa caccgauauu     1320

acucaacuaa agauugauca uaaccccuuu gcaaaaggcu ucagagacaa cuaugauuca     1380

ucccaucaga uugucccugg aggucgguac ggcguucaau ccuucuuccc ggagcccuuu     1440

gucaacacuu uaccucaagc ccgcuauuau aauggcgaga gaaccgugcc acagaccaac     1500

ggccuccuuu caccccaaca gagcgaagag guggccaacc cuccccagcg guggcuuguc     1560

acgccugucc agcaaccugg gaccaacaaa cuagacauca guuccuauga aucugaauau     1620

acuucuagca cauugcuccc auauggcauu aaauccuugc cccuucagac aucccaugcc     1680

cugggguauu acccagaccc aaccuuuccu gcaauggcag gguggggagg ucgagguucu     1740

uaccagagga agauggcagc uggacuacca uggaccucca gaacaagccc cacuguguuc     1800

ucugaagauc agcucuccaa ggagaaagug aaagaggaaa uuggcucuuc uuggauagag     1860

acacccccuu ccaucaaauc ucuagauucc aaugauucag gaguauacac cagugcuugu     1920

aagcgaaggc ggcugucucc uagcaacucc aguaaugaaa auucacccuc cauaaagugu     1980

ggggacauua augcugaaga guauaguaaa gacaccucaa aaggcauggg aggguauuau     2040

gcuuuuuaca caagucccua g                                               2061


<210>  6
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser His Gln Ile 
    450                 455                 460                 


Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro Glu Pro Phe 
465                 470                 475                 480 


Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu Arg Thr Val 
                485                 490                 495     


Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu Glu Val Ala 
            500                 505                 510         


Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln Pro Gly Thr 
        515                 520                 525             


Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr Ser Ser Thr 
    530                 535                 540                 


Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr Ser His Ala 
545                 550                 555                 560 


Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala Gly Trp Gly 
                565                 570                 575     


Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu Pro Trp Thr 
            580                 585                 590         


Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu Ser Lys Glu 
        595                 600                 605             


Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr Pro Pro Ser 
    610                 615                 620                 


Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr Ser Ala Cys 
625                 630                 635                 640 


Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu Asn Ser Pro 
                645                 650                 655     


Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser Lys Asp Thr 
            660                 665                 670         


Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr Pro 
        675                 680                 685     


<210>  7
<211>  849
<212>  RNA
<213>  Homo sapiens

<400>  7
augaggaacu ccuauagauu ucuggcaucc ucucucucag uugucguuuc ucuccugcua       60

auuccugaag augucuguga aaaaauuauu ggaggaaaug aaguaacucc ucauucaaga      120

cccuacaugg uccuacuuag ucuugacaga aaaaccaucu gugcuggggc uuugauugca      180

aaagacuggg uguugacugc agcucacugu aacuugaaca aaagguccca ggucauucuu      240

ggggcucacu caauaaccag ggaagagcca acaaaacaga uaaugcuugu uaagaaagag      300

uuucccuauc caugcuauga cccagccaca cgcgaaggug accuuaaacu uuuacagcug      360

acggaaaaag caaaaauuaa caaauaugug acuauccuuc aucuaccuaa aaagggggau      420

gaugugaaac caggaaccau gugccaaguu gcaggguggg ggaggacuca caauagugca      480

ucuugguccg auacucugag agaagucaau aucaccauca uagacagaaa agucugcaau      540

gaucgaaauc acuauaauuu uaacccugug auuggaauga auaugguuug ugcuggaagc      600

cuccgaggug gaagagacuc gugcaaugga gauucuggaa gcccuuuguu gugcgagggu      660

guuuuccgag gggucacuuc cuuuggccuu gaaaauaaau gcggagaccc ucgugggccu      720

ggugucuaua uucuucucuc aaagaaacac cucaacugga uaauuaugac uaucaaggga      780

gcaguuuaaa uaaccguuuc cuuucauuua cuguggcuuc uuaaucuuuu cacaaauaaa      840

aucaauuug                                                              849


<210>  8
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Asn Ser Tyr Arg Phe Leu Ala Ser Ser Leu Ser Val Val Val 
1               5                   10                  15      


Ser Leu Leu Leu Ile Pro Glu Asp Val Cys Glu Lys Ile Ile Gly Gly 
            20                  25                  30          


Asn Glu Val Thr Pro His Ser Arg Pro Tyr Met Val Leu Leu Ser Leu 
        35                  40                  45              


Asp Arg Lys Thr Ile Cys Ala Gly Ala Leu Ile Ala Lys Asp Trp Val 
    50                  55                  60                  


Leu Thr Ala Ala His Cys Asn Leu Asn Lys Arg Ser Gln Val Ile Leu 
65                  70                  75                  80  


Gly Ala His Ser Ile Thr Arg Glu Glu Pro Thr Lys Gln Ile Met Leu 
                85                  90                  95      


Val Lys Lys Glu Phe Pro Tyr Pro Cys Tyr Asp Pro Ala Thr Arg Glu 
            100                 105                 110         


Gly Asp Leu Lys Leu Leu Gln Leu Met Glu Lys Ala Lys Ile Asn Lys 
        115                 120                 125             


Tyr Val Thr Ile Leu His Leu Pro Lys Lys Gly Asp Asp Val Lys Pro 
    130                 135                 140                 


Gly Thr Met Cys Gln Val Ala Gly Trp Gly Arg Thr His Asn Ser Ala 
145                 150                 155                 160 


Ser Trp Ser Asp Thr Leu Arg Glu Val Asn Ile Thr Ile Ile Asp Arg 
                165                 170                 175     


Lys Val Cys Asn Asp Arg Asn His Tyr Asn Phe Asn Pro Val Ile Gly 
            180                 185                 190         


Met Asn Met Val Cys Ala Gly Ser Leu Arg Gly Gly Arg Asp Ser Cys 
        195                 200                 205             


Asn Gly Asp Ser Gly Ser Pro Leu Leu Cys Glu Gly Val Phe Arg Gly 
    210                 215                 220                 


Val Thr Ser Phe Gly Leu Glu Asn Lys Cys Gly Asp Pro Arg Gly Pro 
225                 230                 235                 240 


Gly Val Tyr Ile Leu Leu Ser Lys Lys His Leu Asn Trp Ile Ile Met 
                245                 250                 255     


Thr Ile Lys Gly Ala Val 
            260         


<210>  9
<211>  934
<212>  RNA
<213>  Homo sapiens

<400>  9
ugagaagaug caaccaaucc ugcuucugcu ggccuuccuc cugcugccca gggcagaugc       60

aggggagauc aucgggggac augaggccaa gccccacucc cgccccuaca uggcuuaucu      120

uaugaucugg gaucagaagu cucugaagag gugcgguggc uuccugauac aagacgacuu      180

cgugcugaca gcugcucacu guuggggaag cuccauaaau gucaccuugg gggcccacaa      240

uaucaaagaa caggagccga cccagcaguu uaucccugug aaaagaccca ucccccaucc      300

agccuauaau ccuaagaacu ucuccaacga caucaugcua cugcagcugg agagaaaggc      360

caagcggacc agagcugugc agccccucag gcuaccuagc aacaaggccc aggugaagcc      420

agggcagaca ugcagugugg ccggcugggg gcagacggcc ccccugggaa aacacucaca      480

cacacuacaa gaggugaaga ugacagugca ggaagaucga aagugcgaau cugacuuacg      540

ccauuauuac gacaguacca uugaguugug cgugggggac ccagagauua aaaagacuuc      600

cuuuaagggg gacucuggag gcccucuugu guguaacaag guggcccagg gcauugucuc      660

cuauggacga aacaauggca ugccuccacg agccugcacc aaagucucaa gcuuuguaca      720

cuggauaaag aaaaccauga aacgcuacua acuacaggaa gcaaacuaag cccccgcugu      780

aaugaaacac cuucucugga gccaagucca gauuuacacu gggagaggug ccagcaacug      840

aauaaauacc ucucccagug uaaaucugga gccaagucca gauuuacacu gggagaggug      900

ccagcaacug aauaaauacc ucuuagcuga gugg                                  934


<210>  10
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Pro Ile Leu Leu Leu Leu Ala Phe Leu Leu Leu Pro Arg Ala 
1               5                   10                  15      


Asp Ala Gly Glu Ile Ile Gly Gly His Glu Ala Lys Pro His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Tyr Leu Met Ile Trp Asp Gln Lys Ser Leu Lys Arg 
        35                  40                  45              


Cys Gly Gly Phe Leu Ile Arg Asp Asp Phe Val Leu Thr Ala Ala His 
    50                  55                  60                  


Cys Trp Gly Ser Ser Ile Asn Val Thr Leu Gly Ala His Asn Ile Lys 
65                  70                  75                  80  


Glu Gln Glu Pro Thr Gln Gln Phe Ile Pro Val Lys Arg Pro Ile Pro 
                85                  90                  95      


His Pro Ala Tyr Asn Pro Lys Asn Phe Ser Asn Asp Ile Met Leu Leu 
            100                 105                 110         


Gln Leu Glu Arg Lys Ala Lys Arg Thr Arg Ala Val Gln Pro Leu Arg 
        115                 120                 125             


Leu Pro Ser Asn Lys Ala Gln Val Lys Pro Gly Gln Thr Cys Ser Val 
    130                 135                 140                 


Ala Gly Trp Gly Gln Thr Ala Pro Leu Gly Lys His Ser His Thr Leu 
145                 150                 155                 160 


Gln Glu Val Lys Met Thr Val Gln Glu Asp Arg Lys Cys Glu Ser Asp 
                165                 170                 175     


Leu Arg His Tyr Tyr Asp Ser Thr Ile Glu Leu Cys Val Gly Asp Pro 
            180                 185                 190         


Glu Ile Lys Lys Thr Ser Phe Lys Gly Asp Ser Gly Gly Pro Leu Val 
        195                 200                 205             


Cys Asn Lys Val Ala Gln Gly Ile Val Ser Tyr Gly Arg Asn Asn Gly 
    210                 215                 220                 


Met Pro Pro Arg Ala Cys Thr Lys Val Ser Ser Phe Val His Trp Ile 
225                 230                 235                 240 


Lys Lys Thr Met Lys Arg Tyr 
                245         


<210>  11
<211>  1193
<212>  RNA
<213>  Homo sapiens

<400>  11
ugaagaucag cuauuagaag agaaagauca guuaaguccu uuggaccuga ucagcuugau       60

acaagaacua cugauuucaa cuucuuuggc uuaauucucu cggaaacgau gaaauauaca      120

aguuauaucu uggcuuuuca gcucugcauc guuuuggguu cucuuggcug uuacugccag      180

gacccauaug uaaaagaagc agaaaaccuu aagaaauauu uuaaugcagg ucauucagau      240

guagcggaua auggaacucu uuucuuaggc auuuugaaga auuggaaaga ggagagugac      300

agaaaaauaa ugcagagcca aauugucucc uuuuacuuca aacuuuuuaa aaacuuuaaa      360

gaugaccaga gcauccaaaa gaguguggag accaucaagg aagacaugaa ugucaaguuu      420

uucaauagca acaaaaagaa acgagaugac uucgaaaagc ugacuaauua uucgguaacu      480

gacuugaaug uccaacgcaa agcaauacau gaacucaucc aagugauggc ugaacugucg      540

ccagcagcua aaacagggaa gcgaaaaagg agucagaugc uguuucaagg ucgaagagca      600

ucccaguaau gguuguccug ccugcaauau uugaauuuua aaucuaaauc uauuuauuaa      660

uauuuaacau uauuuauaug gggaauauau uuuuagacuc aucaaucaaa uaaguauuua      720

uaauagcaac uuuuguguaa ugaaaaugaa uaucuauuaa uauauguauu auuuauaauu      780

ccuauauccu gugacugucu cacuuaaucc uuuguuuucu gacuaauuag gcaaggcuau      840

gugauuacaa ggcuuuaucu caggggccaa cuaggcagcc aaccuaagca agaucccaug      900

gguugugugu uuauuucacu ugaugauaca augaacacuu auaagugaag ugauacuauc      960

caguuacugc cgguuugaaa auaugccugc aaucugagcc agugcuuuaa uggcauguca     1020

gacagaacuu gaauguguca ggugacccug augaaaacau agcaucucag gagauuucau     1080

gccuggugcu uccaaauauu guugacaacu gugacuguac ccaaauggaa aguaacucau     1140

uuguuaaaau uaucaauauc uaauauauau gaauaaagug uaaguucaca acu            1193


<210>  12
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  13
<211>  1668
<212>  RNA
<213>  Homo sapiens

<400>  13
auggcagccc gucugcuccu ccugggcauc cuucuccugc ugcugccccu gcccgucccu       60

gccccgugcc acacagccgc acgcucagag ugcaagcgca gccacaaguu cgugccuggu      120

gcauggcugg ccggggaggg uguggacgug accagccucc gccgcucggg cuccuuccca      180

guggacacac aaagguuccu gcggcccgac ggcaccugca cccucuguga aaaugcccua      240

caggagggca cccuccagcg ccugccucug gcgcucacca acuggcgggc ccagggcucu      300

ggcugccagc gccauguaac cagggccaaa gucagcucca cugaagcugu ggcccgggau      360

gcggcucgua gcauccgcaa cgacuggaag gucgggcugg acgugacucc uaagcccacc      420

agcaaugugc augugucugu ggccggcuca cacucacagg cagccaacuu ugcagcccag      480

aagacccacc aggaccagua cagcuucagc acugacacgg uggagugccg cuucuacagu      540

uuccaugugg uacacacucc cccgcugcac ccugacuuca agagggcccu cggggaccug      600

ccccaccacu ucaacgccuc cacccagccc gccuaccuca ggcuuaucuc caacuacggc      660

acccacuuca uccgggcugu ggagcugggu ggccgcauau cggcccucac ugcccugcgc      720

accugcgagc uggcccugga agggcucacg gacaacgagg uggaggacug ccugacuguc      780

gaggcccagg ucaacauagg cauccacggc agcaucucug ccgaagccaa ggccugugag      840

gagaagaaga agaagcacaa gaugacggcc uccuuccacc aaaccuaccg ggagcgccac      900

ucggaagugg uuggcggcca ucacaccucc auuaacgacc ugcuguucgg gauccaggcc      960

gggcccgagc aguacucagc cuggguaaac uccgugcccg gcagcccugg ccugguggac     1020

uacacccugg aaccccugca cgugcugcug gacagccagg acccgcggcg ggaggcacug     1080

aggagggccc ugagucagua ccugacggac agggcucgcu ggagggacug cagccggccg     1140

ugcccaccag ggcggcagaa gagcccccga gacccaugcc agugugugug ccauggcuca     1200

gcggucacca cccaggacug cugcccucgg cagaggggcc uggcccagcu ggaggugacc     1260

uucauccaag cauggagccu guggggggac ugguucacug ccacggaugc cuaugugaag     1320

cucuucuuug guggccagga gcugaggacg agcaccgugu gggacaauaa caaccccauc     1380

uggucagugc ggcuggauuu uggggaugug cuccuggcca caggggggcc ccugagguug     1440

caggucuggg aucaggacuc uggcagggac gaugaccucc uuggcaccug ugaucaggcu     1500

cccaagucug guucccauga ggugagaugc aaccugaauc auggccaccu aaaauuccgc     1560

uaucaugcca ggugcuugcc ccaccuggga ggaggcaccu gccuggacua ugucccccaa     1620

augcuucugg gggagccucc aggaaaccgg aguggggccg ugugguga                  1668


<210>  14
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ala Arg Leu Leu Leu Leu Gly Ile Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Pro Val Pro Ala Pro Cys His Thr Ala Ala Arg Ser Glu Cys Lys 
            20                  25                  30          


Arg Ser His Lys Phe Val Pro Gly Ala Trp Leu Ala Gly Glu Gly Val 
        35                  40                  45              


Asp Val Thr Ser Leu Arg Arg Ser Gly Ser Phe Pro Val Asp Thr Gln 
    50                  55                  60                  


Arg Phe Leu Arg Pro Asp Gly Thr Cys Thr Leu Cys Glu Asn Ala Leu 
65                  70                  75                  80  


Gln Glu Gly Thr Leu Gln Arg Leu Pro Leu Ala Leu Thr Asn Trp Arg 
                85                  90                  95      


Ala Gln Gly Ser Gly Cys Gln Arg His Val Thr Arg Ala Lys Val Ser 
            100                 105                 110         


Ser Thr Glu Ala Val Ala Arg Asp Ala Ala Arg Ser Ile Arg Asn Asp 
        115                 120                 125             


Trp Lys Val Gly Leu Asp Val Thr Pro Lys Pro Thr Ser Asn Val His 
    130                 135                 140                 


Val Ser Val Ala Gly Ser His Ser Gln Ala Ala Asn Phe Ala Ala Gln 
145                 150                 155                 160 


Lys Thr His Gln Asp Gln Tyr Ser Phe Ser Thr Asp Thr Val Glu Cys 
                165                 170                 175     


Arg Phe Tyr Ser Phe His Val Val His Thr Pro Pro Leu His Pro Asp 
            180                 185                 190         


Phe Lys Arg Ala Leu Gly Asp Leu Pro His His Phe Asn Ala Ser Thr 
        195                 200                 205             


Gln Pro Ala Tyr Leu Arg Leu Ile Ser Asn Tyr Gly Thr His Phe Ile 
    210                 215                 220                 


Arg Ala Val Glu Leu Gly Gly Arg Ile Ser Ala Leu Thr Ala Leu Arg 
225                 230                 235                 240 


Thr Cys Glu Leu Ala Leu Glu Gly Leu Thr Asp Asn Glu Val Glu Asp 
                245                 250                 255     


Cys Leu Thr Val Glu Ala Gln Val Asn Ile Gly Ile His Gly Ser Ile 
            260                 265                 270         


Ser Ala Glu Ala Lys Ala Cys Glu Glu Lys Lys Lys Lys His Lys Met 
        275                 280                 285             


Thr Ala Ser Phe His Gln Thr Tyr Arg Glu Arg His Ser Glu Val Val 
    290                 295                 300                 


Gly Gly His His Thr Ser Ile Asn Asp Leu Leu Phe Gly Ile Gln Ala 
305                 310                 315                 320 


Gly Pro Glu Gln Tyr Ser Ala Trp Val Asn Ser Leu Pro Gly Ser Pro 
                325                 330                 335     


Gly Leu Val Asp Tyr Thr Leu Glu Pro Leu His Val Leu Leu Asp Ser 
            340                 345                 350         


Gln Asp Pro Arg Arg Glu Ala Leu Arg Arg Ala Leu Ser Gln Tyr Leu 
        355                 360                 365             


Thr Asp Arg Ala Arg Trp Arg Asp Cys Ser Arg Pro Cys Pro Pro Gly 
    370                 375                 380                 


Arg Gln Lys Ser Pro Arg Asp Pro Cys Gln Cys Val Cys His Gly Ser 
385                 390                 395                 400 


Ala Val Thr Thr Gln Asp Cys Cys Pro Arg Gln Arg Gly Leu Ala Gln 
                405                 410                 415     


Leu Glu Val Thr Phe Ile Gln Ala Trp Gly Leu Trp Gly Asp Trp Phe 
            420                 425                 430         


Thr Ala Thr Asp Ala Tyr Val Lys Leu Phe Phe Gly Gly Gln Glu Leu 
        435                 440                 445             


Arg Thr Ser Thr Val Trp Asp Asn Asn Asn Pro Ile Trp Ser Val Arg 
    450                 455                 460                 


Leu Asp Phe Gly Asp Val Leu Leu Ala Thr Gly Gly Pro Leu Arg Leu 
465                 470                 475                 480 


Gln Val Trp Asp Gln Asp Ser Gly Arg Asp Asp Asp Leu Leu Gly Thr 
                485                 490                 495     


Cys Asp Gln Ala Pro Lys Ser Gly Ser His Glu Val Arg Cys Asn Leu 
            500                 505                 510         


Asn His Gly His Leu Lys Phe Arg Tyr His Ala Arg Cys Leu Pro His 
        515                 520                 525             


Leu Gly Gly Gly Thr Cys Leu Asp Tyr Val Pro Gln Met Leu Leu Gly 
    530                 535                 540                 


Glu Pro Pro Gly Asn Arg Ser Gly Ala Val Trp 
545                 550                 555 


<210>  15
<211>  2545
<212>  RNA
<213>  Homo sapiens

<400>  15
auccaauaca ggagugacuu ggaacuccau ucuaucacua ugaagaaaag ugguguucuu       60

uuccucuugg gcaucaucuu gcugguucug auuggagugc aaggaacccc aguagugaga      120

aagggucgcu guuccugcau cagcaccaac caagggacua uccaccuaca auccuugaaa      180

gaccuuaaac aauuugcccc aagcccuucc ugcgagaaaa uugaaaucau ugcuacacug      240

aagaauggag uucaaacaug ucuaaaccca gauucagcag augugaagga acugauuaaa      300

aagugggaga aacaggucag ccaaaagaaa aagcaaaaga augggaaaaa acaucaaaaa      360

aagaaaguuc ugaaaguucg aaaaucucaa cguucucguc aaaagaagac uacauaagag      420

accacuucac caauaaguau ucuguguuaa aaauguucua uuuuaauuau accgcuauca      480

uuccaaagga ggauggcaua uaauacaaag gcuuauuaau uugacuagaa aauuuaaaac      540

auuacucuga aauuguaacu aaaguuagaa aguugauuuu aagaauccaa acguuaagaa      600

uuguuaaagg cuaugauugu cuuuguucuu cuaccaccca ccaguugaau uucaucaugc      660

uuaaggccau gauuuuagca auacccaugu cuacacagau guucacccaa ccacauccca      720

cucacaacag cugccuggaa gagcagcccu aggcuuccac guacugcagc cuccagagag      780

uaucugaggc acaugucagc aaguccuaag ccuguuagca ugcuggugag ccaagcaguu      840

ugaaauugag cuggaccuca ccaagcugcu guggccauca accucuguau uugaaucagc      900

cuacaggccu cacacacaau gugucugaga gauucaugcu gauuguuauu ggguaucacc      960

acuggagauc accagugugu ggcuuucaga gccuccuuuc uggcuuugga agccauguga     1020

uuccaucuug cccgcucagg cugaccacuu uauuucuuuu uguuccccuu ugcuucauuc     1080

aagucagcuc uucuccaucc uaccacaaug cagugccuuu cuucucucca gugcaccugu     1140

cauaugcucu gauuuaucug agucaacucc uuucucaucu uguccccaac accccacaga     1200

agugcuuucu ucucccaauu cauccucacu caguccagcu uaguucaagu ccugccucuu     1260

aaauaaaccu uuuuggacac acaaauuauc uuaaaacucc uguuucacuu gguucaguac     1320

cacaugggug aacacucaau gguuaacuaa uucuugggug uuuauccuau cucuccaacc     1380

agauugucag cuccuugagg gcaagagcca caguauauuu cccuguuucu uccacagugc     1440

cuaauaauac uguggaacua gguuuuaaua auuuuuuaau ugauguuguu augggcagga     1500

uggcaaccag accauugucu cagagcaggu gcuggcucuu uccuggcuac uccauguugg     1560

cuagccucug guaaccucuu acuuauuauc uucaggacac ucacuacagg gaccagggau     1620

gaugcaacau ccuugucuuu uuaugacagg auguuugcuc agcuucucca acaauaagaa     1680

gcacguggua aaacacuugc ggauauucug gacuguuuuu aaaaaauaua caguuuaccg     1740

aaaaucauau aaucuuacaa ugaaaaggac uuuauagauc agccagugac caaccuuuuc     1800

ccaaccauac aaaaauuccu uuucccgaag gaaaagggcu uucucaauaa gccucagcuu     1860

ucuaagaucu aacaagauag ccaccgagau ccuuaucgaa acucauuuua ggcaaauaug     1920

aguuuuauug uccguuuacu uguuucagag uuuguauugu gauuaucaau uaccacacca     1980

ucucccauga agaaagggaa cggugaagua cuaagcgcua gaggaagcag ccaagucggu     2040

uaguggaagc augauuggug cccaguuagc cucugcagga uguggaaacc uccuuccagg     2100

ggagguucag ugaauugugu aggagagguu gucuguggcc agaauuuaaa ccuauacuca     2160

cuuucccaaa uugaaucacu gcucacacug cugaugauuu agagugcugu ccgguggaga     2220

ucccacccga acgucuuauc uaaucaugaa acucccuagu uccuucaugu aacuucccug     2280

aaaaaucuaa guguuucaua aauuugagag ucugugaccc acuuaccuug caucucacag     2340

guagacagua uauaacuaac aaccaaagac uacauauugu cacugacaca cacguuauaa     2400

ucauuuauca uauauauaca uacaugcaua cacucucaaa gcaaauaauu uuucacuuca     2460

aaacaguauu gacuuguaua ccuuguaauu ugaaauauuu ucuuuguuaa aauagaaugg     2520

uaucaauaaa uagaccauua aucag                                           2545


<210>  16
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Lys Lys Ser Gly Val Leu Phe Leu Leu Gly Ile Ile Leu Leu Val 
1               5                   10                  15      


Leu Ile Gly Val Gln Gly Thr Pro Val Val Arg Lys Gly Arg Cys Ser 
            20                  25                  30          


Cys Ile Ser Thr Asn Gln Gly Thr Ile His Leu Gln Ser Leu Lys Asp 
        35                  40                  45              


Leu Lys Gln Phe Ala Pro Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile 
    50                  55                  60                  


Ala Thr Leu Lys Asn Gly Val Gln Thr Cys Leu Asn Pro Asp Ser Ala 
65                  70                  75                  80  


Asp Val Lys Glu Leu Ile Lys Lys Trp Glu Lys Gln Val Ser Gln Lys 
                85                  90                  95      


Lys Lys Gln Lys Asn Gly Lys Lys His Gln Lys Lys Lys Val Leu Lys 
            100                 105                 110         


Val Arg Lys Ser Gln Arg Ser Arg Gln Lys Lys Thr Thr 
        115                 120                 125 


<210>  17
<211>  1172
<212>  RNA
<213>  Homo sapiens

<400>  17
gagacauucc ucaauugcuu agacauauuc ugagccuaca gcagaggaac cuccagucuc       60

agcaccauga aucaaacugc gauucugauu ugcugccuua ucuuucugac ucuaaguggc      120

auucaaggag uaccucucuc uagaaccgua cgcuguaccu gcaucagcau uaguaaucaa      180

ccuguuaauc caaggucuuu agaaaaacuu gaaauuauuc cugcaagcca auuuugucca      240

cguguugaga ucauugcuac aaugaaaaag aagggugaga agagaugucu gaauccagaa      300

ucgaaggcca ucaagaauuu acugaaagca guuagcaagg aaaugucuaa aagaucuccu      360

uaaaaccaga ggggagcaaa aucgaugcag ugcuuccaag gauggaccac acagaggcug      420

ccucucccau cacuucccua cauggaguau augucaagcc auaauuguuc uuaguuugca      480

guuacacuaa aaggugacca augaugguca ccaaaucagc ugcuacuacu ccuguaggaa      540

gguuaauguu caucauccua agcuauucag uaauaacucu acccuggcac uauaauguaa      600

gcucuacuga ggugcuaugu ucuuagugga uguucugacc cugcuucaaa uauuucccuc      660

accuuuccca ucuuccaagg guacuaagga aucuuucugc uuugggguuu aucagaauuc      720

ucagaaucuc aaauaacuaa aagguaugca aucaaaucug cuuuuuaaag aaugcucuuu      780

acuucaugga cuuccacugc cauccuccca aggggcccaa auucuuucag uggcuaccua      840

cauacaauuc caaacacaua caggaaggua gaaauaucug aaaauguaug uguaaguauu      900

cuuauuuaau gaaagacugu acaaaguaua agucuuagau guauauauuu ccuauauugu      960

uuucagugua cauggaauaa cauguaauua aguacuaugu aucaaugagu aacaggaaaa     1020

uuuuaaaaau acagauagau auaugcucug cauguuacau aagauaaaug ugcugaaugg     1080

uuuucaaaua aaaaugaggu acucuccugg aaauauuaag aaagacuauc uaaauguuga     1140

aagaucaaaa gguuaauaaa guaauuauaa cu                                   1172


<210>  18
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asn Gln Thr Ala Ile Leu Ile Cys Cys Leu Ile Phe Leu Thr Leu 
1               5                   10                  15      


Ser Gly Ile Gln Gly Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys 
            20                  25                  30          


Ile Ser Ile Ser Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu 
        35                  40                  45              


Glu Ile Ile Pro Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala 
    50                  55                  60                  


Thr Met Lys Lys Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys 
65                  70                  75                  80  


Ala Ile Lys Asn Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg 
                85                  90                  95      


Ser Pro 
        


<210>  19
<211>  995
<212>  RNA
<213>  Homo sapiens

<400>  19
gaauucggcc aaagaggccu acuuccaaga agagcagcaa agcugaagua gcagcaacag       60

caccagcagc aacagcaaaa aacaaacaug agugugaagg gcauggcuau agccuuggcu      120

gugauauugu gugcuacagu uguucaaggc uuccccaugu ucaaaagagg acgcugucuu      180

ugcauaggcc cugggguaaa agcagugaaa guggcagaua uugagaaagc cuccauaaug      240

uacccaagua acaacuguga caaaauagaa gugauuauua cccugaaaga aaauaaagga      300

caacgaugcc uaaaucccaa aucgaagcaa gcaaggcuua uaaucaaaaa aguugaaaga      360

aagaauuuuu aaaaauauca aaacauauga aguccuggaa aagggcaucu gaaaaaccua      420

gaacaaguuu aacugugacu acugaaauga caagaauucu acaguaggaa acugagacuu      480

uucuaugguu uugugacuuu caacuuuugu acaguuaugu gaaggaugaa agguggguga      540

aaggaccaaa aacagaaaua cagucuuccu gaaugaauga caaucagaau uccacugccc      600

aaaggagucc aacaauuaaa uggauuucua ggaaaagcua ccuuaagaaa ggcugguuac      660

caucggaguu uacaaagugc uuucacguuc uuacuuguug uauuauacau ucaugcauuu      720

cuaggcuaga gaaccuucua gauuugaugc uuacaacuau ucuguuguga cuaugagaac      780

auuucugucu cuagaaguua ucugucugua uugaucuuua ugcuauauua cuaucugugg      840

uuacagugga gacauugaca uuauuacugg agucaagccc uuauaaguca aaagcaccua      900

ugugucguaa agcauuccuc aaacauuuaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      960

aaaaaaaaaa aaaaaaaaaa aaaaaaagcg gccgc                                 995


<210>  20
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Val Lys Gly Met Ala Ile Ala Leu Ala Val Ile Leu Cys Ala 
1               5                   10                  15      


Thr Val Val Gln Gly Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys 
            20                  25                  30          


Ile Gly Pro Gly Val Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala 
        35                  40                  45              


Ser Ile Met Tyr Pro Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile 
    50                  55                  60                  


Thr Leu Lys Glu Asn Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys 
65                  70                  75                  80  


Gln Ala Arg Leu Ile Ile Lys Lys Val Glu Arg Lys Asn Phe 
                85                  90                  


<210>  21
<211>  1216
<212>  RNA
<213>  Homo sapiens

<400>  21
uucggcacuu gggagaagau guuugaaaaa acugacucug cuaaugagcc uggacucaga       60

gcucaagucu gaacucuacc uccagacaga augaaguuca ucucgacauc ucugcuucuc      120

augcugcugg ucagcagccu cucuccaguc caagguguuc uggaggucua uuacacaagc      180

uugaggugua gaugugucca agagagcuca gucuuuaucc cuagacgcuu cauugaucga      240

auucaaaucu ugccccgugg gaaugguugu ccaagaaaag aaaucauagu cuggaagaag      300

aacaagucaa uugugugugu ggacccucaa gcugaaugga uacaaagaau gauggaagua      360

uugagaaaaa gaaguucuuc aacucuacca guuccagugu uuaagagaaa gauucccuga      420

ugcugauauu uccacuaaga acaccugcau ucuucccuua ucccugcucu ggauuuuagu      480

uuugugcuua guuaaaucuu uuccagggag aaagaacuuc cccauacaaa uaaggcauga      540

ggacuaugug aaaaauaacc uugcaggagc ugauggggca aacucaagcu ucuucacuca      600

cagcacccua uauacacuug gaguuugcau ucuuauucau cagggaggaa aguuucuuug      660

aaaauaguua uucaguuaua aguaauacag gauuauuuug auuauauacu uguuguuuaa      720

uguuuaaaau uucuuagaaa acaauggaau gagaauuuaa gccucaaauu ugaacaugug      780

gcuugaauua agaagaaaau uauggcauau auuaaaagca ggcuucuaug aaagacucaa      840

aaagcugccu gggaggcaga uggaacuuga gccugucaag aggcaaagga auccauguag      900

uagauauccu cugcuuaaaa acucacuacg gaggagaauu aaguccuacu uuuaaagaau      960

uucuuuauaa aauuuacugu cuaagauuaa uagcauucga agauccccag acuucauaga     1020

auacucaggg aaagcauuua aagggugaug uacacaugua uccuuucaca cauuugccuu     1080

gacaaacuuc uuucacucac aucuuuuuca cugacuuuuu uugugggggc ggggccgggg     1140

ggacucuggu aucuaauucu uuaaugauuc cuauaaaucu aaugacauuc aauaaaguug     1200

agcaaacauu uuacuu                                                     1216


<210>  22
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  23
<211>  1770
<212>  RNA
<213>  Homo sapiens

<400>  23
gaggagugga uuacauauuc caacaguugu uauuacauug guaaggaaag aagaacuugg       60

gaagaaagag uuugcuggcc ugugcuucga agaacucuga ucugcuuucu auagauaaug      120

aggaagaaau gguaugugug gggacuuccc aguuggcugu aaguugccau uugaacuaaa      180

cgaaauagau caggaacuga ggacauaucu aaauuuucua guuuuauaga aggcuuuuau      240

ccacaagaau caagaucuuc ccucucugag caggaauccu uugugcauug aagacuuuag      300

auuccucucu gcgguagacg ugcacuuaua aguauuugau gggguggauu cguggucgga      360

ggucucgaca cagcugggag augagugaau uucauaauua uaacuuggau cugaagaaga      420

gugauuuuuc aacacgaugg caaaagcaaa gauguccagu agucaaaagc aaauguagag      480

aaaaugcauc uccauuuuuu uucugcugcu ucaucgcugu agccauggga auccguuuca      540

uuauuauggu agcaauaugg agugcuguau uccuaaacuc auuauucaac caagaaguuc      600

aaauucccuu gaccgaaagu uacuguggcc cauguccuaa aaacuggaua uguuacaaaa      660

auaacugcua ccaauuuuuu gaugagagua aaaacuggua ugagagccag gcuucuugua      720

ugucucaaaa ugccagccuu cugaaaguau acagcaaaga ggaccaggau uuacuuaaac      780

uggugaaguc auaucauugg augggacuag uacacauucc aacaaaugga ucuuggcagu      840

gggaagaugg cuccauucuc ucacccaacc uacuaacaau aauugaaaug cagaagggag      900

acugugcacu cuaugccucg agcuuuaaag gcuauauaga aaacuguuca acuccaaaua      960

cauacaucug caugcaaagg acuguguaaa gaugaucaac caucucaaua aaagccagga     1020

acagagaaga gauuacacca gcgguaacac ugccaaccga gacuaaagga aacaaacaaa     1080

aacaggacaa aaugaccaaa gacugucaga uuucuuagac uccacaggac caaaccauag     1140

aacaauuuca cugcaaacau gcaugauucu ccaagacaaa agaagagaga uccuaaaggc     1200

aauucagaua uccccaaggc ugccucuccc accacaagcc cagaguggau gggcuggggg     1260

aggggugcug uuuuaauuuc uaaagguagg accaacaccc aggggaucag ugaaggaaga     1320

gaaggccagc agaucaguga gagugcaacc ccacccucca caggaaauug ccucaugggc     1380

agggccacag cagagagaca cagcaugggc agugccuucc cugccugugg gggucaugcu     1440

gccacuuuua auggguccuc cacccaacgg ggucagggag guggugcugc cccagugggc     1500

caugauuauc uuaaaggcau uauucuccag ccuuaagauc uuaggacguu uccuuugcua     1560

ugauuuguac uugcuugagu cccaugacug uuucucuucc ucucuuucuu ccuuuuggaa     1620

uaguaauauc cauccuaugu uugucccacu auuguauuuu ggaagcacau aacuuguuug     1680

guuucacagg uucacaguua agaaggaauu uugccucuga auaaauagaa ucuugagucu     1740

caugcaaaaa aaaaaaaaaa aaaaaaaaaa                                      1770


<210>  24
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  25
<211>  1083
<212>  RNA
<213>  Homo sapiens

<400>  25
cagagagcaa uauggcuggu uccccaacau gccucacccu caucuauauc cuuuggcagc       60

ucacaggguc agcagccucu ggacccguga aagagcuggu cgguuccguu gguggggccg      120

ugacuuuccc ccugaagucc aaaguaaagc aaguugacuc uauugucugg accuucaaca      180

caaccccucu ugucaccaua cagccagaag ggggcacuau cauagugacc caaaaucgua      240

auagggagag aguagacuuc ccagauggag gcuacucccu gaagcucagc aaacugaaga      300

agaaugacuc agggaucuac uaugugggga uauacagcuc aucacuccag cagcccucca      360

cccaggagua cgugcugcau gucuacgagc accugucaaa gccuaaaguc accauggguc      420

ugcagagcaa uaagaauggc accuguguga ccaaucugac augcugcaug gaacaugggg      480

aagaggaugu gauuuauacc uggaaggccc uggggcaagc agccaaugag ucccauaaug      540

gguccauccu ccccaucucc uggagauggg gagaaaguga uaugaccuuc aucugcguug      600

ccaggaaccc ugucagcaga aacuucucaa gccccauccu ugccaggaag cucugugaag      660

gugcugcuga ugacccagau uccuccaugg uccuccugug ucuccuguug gugccccucc      720

ugcucagucu cuuuguacug gggcuauuuc uuugguuucu gaagagagag agacaagaag      780

aguacauuga agagaagaag agaguggaca uuugucggga aacuccuaac auaugccccc      840

auucuggaga gaacacagag uacgacacaa ucccucacac uaauagaaca auccuaaagg      900

aagauccagc aaauacgguu uacuccacug uggaaauacc gaaaaagaug gaaaaucccc      960

acucacugcu cacgaugcca gacacaccaa ggcuauuugc cuaugagaau guuaucuaga     1020

cagcagugca cugccccuaa gucucugcuc aaaaaaaaaa caauucucgg cccaaagaaa     1080

aca                                                                   1083


<210>  26
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Gly Ser Pro Thr Cys Leu Thr Leu Ile Tyr Ile Leu Trp Gln 
1               5                   10                  15      


Leu Thr Gly Ser Ala Ala Ser Gly Pro Val Lys Glu Leu Val Gly Ser 
            20                  25                  30          


Val Gly Gly Ala Val Thr Phe Pro Leu Lys Ser Lys Val Lys Gln Val 
        35                  40                  45              


Asp Ser Ile Val Trp Thr Phe Asn Thr Thr Pro Leu Val Thr Ile Gln 
    50                  55                  60                  


Pro Glu Gly Gly Thr Ile Ile Val Thr Gln Asn Arg Asn Arg Glu Arg 
65                  70                  75                  80  


Val Asp Phe Pro Asp Gly Gly Tyr Ser Leu Lys Leu Ser Lys Leu Lys 
                85                  90                  95      


Lys Asn Asp Ser Gly Ile Tyr Tyr Val Gly Ile Tyr Ser Ser Ser Leu 
            100                 105                 110         


Gln Gln Pro Ser Thr Gln Glu Tyr Val Leu His Val Tyr Glu His Leu 
        115                 120                 125             


Ser Lys Pro Lys Val Thr Met Gly Leu Gln Ser Asn Lys Asn Gly Thr 
    130                 135                 140                 


Cys Val Thr Asn Leu Thr Cys Cys Met Glu His Gly Glu Glu Asp Val 
145                 150                 155                 160 


Ile Tyr Thr Trp Lys Ala Leu Gly Gln Ala Ala Asn Glu Ser His Asn 
                165                 170                 175     


Gly Ser Ile Leu Pro Ile Ser Trp Arg Trp Gly Glu Ser Asp Met Thr 
            180                 185                 190         


Phe Ile Cys Val Ala Arg Asn Pro Val Ser Arg Asn Phe Ser Ser Pro 
        195                 200                 205             


Ile Leu Ala Arg Lys Leu Cys Glu Gly Ala Ala Asp Asp Pro Asp Ser 
    210                 215                 220                 


Ser Met Val Leu Leu Cys Leu Leu Leu Val Pro Leu Leu Leu Ser Leu 
225                 230                 235                 240 


Phe Val Leu Gly Leu Phe Leu Trp Phe Leu Lys Arg Glu Arg Gln Glu 
                245                 250                 255     


Glu Tyr Ile Glu Glu Lys Lys Arg Val Asp Ile Cys Arg Glu Thr Pro 
            260                 265                 270         


Asn Ile Cys Pro His Ser Gly Glu Asn Thr Glu Tyr Asp Thr Ile Pro 
        275                 280                 285             


His Thr Asn Arg Thr Ile Leu Lys Glu Asp Pro Ala Asn Thr Val Tyr 
    290                 295                 300                 


Ser Thr Val Glu Ile Pro Lys Lys Met Glu Asn Pro His Ser Leu Leu 
305                 310                 315                 320 


Thr Met Pro Asp Thr Pro Arg Leu Phe Ala Tyr Glu Asn Val Ile 
                325                 330                 335 


<210>  27
<211>  3100
<212>  RNA
<213>  Homo sapiens

<400>  27
acucgucucu gguaaagucu gagcaggaca ggguggcuga cuggcagauc cagagguucc       60

cuuggcaguc cacgccaggc cuucaccaug gaucaguucc cugaaucagu gacagaaaac      120

uuugaguacg augauuuggc ugaggccugu uauauugggg acaucguggu cuuugggacu      180

guguuccugu ccauauucua cuccgucauc uuugccauug gccugguggg aaauuuguug      240

guaguguuug cccucaccaa cagcaagaag cccaagagug ucaccgacau uuaccuccug      300

aaccuggccu ugucugaucu gcuguuugua gccacuuugc ccuucuggac ucacuauuug      360

auaaaugaaa agggccucca caaugccaug ugcaaauuca cuaccgccuu cuucuucauc      420

ggcuuuuuug gaagcauauu cuucaucacc gucaucagca uugauaggua ccuggccauc      480

guccuggccg ccaacuccau gaacaaccgg accgugcagc auggcgucac caucagccua      540

ggcgucuggg cagcagccau uuugguggca gcaccccagu ucauguucac aaagcagaaa      600

gaaaaugaau gccuugguga cuaccccgag guccuccagg aaaucuggcc cgugcuccgc      660

aauguggaaa caaauuuucu uggcuuccua cucccccugc ucauuaugag uuauugcuac      720

uucagaauca uccagacgcu guuuuccugc aagaaccaca agaaagccaa agccauuaaa      780

cugauccuuc ugguggucau cguguuuuuc cucuucugga cacccuacaa cguuaugauu      840

uuccuggaga cgcuuaagcu cuaugacuuc uuucccaguu gugacaugag gaaggaucug      900

aggcuggccc ucagugugac ugagacgguu gcauuuagcc auuguugccu gaauccucuc      960

aucuaugcau uugcugggga gaaguucaga agauaccuuu accaccugua ugggaaaugc     1020

cuggcugucc ugugugggcg cucaguccac guugauuucu ccucaucuga aucacaaagg     1080

agcaggcaug gaaguguucu gagcagcaau uuuacuuacc acacgaguga uggagaugca     1140

uugcuccuuc ucugaaggga aucccaaagc cuugugucua cagagaaccu ggaguuccug     1200

aaccugaugc ugacuaguga ggaaagauuu uuguuguuau uucuuacagg cacaaaauga     1260

uggacccaau gcacacaaaa caacccuaga guguuguuga gaauugugcu caaaauuuga     1320

agaaugaaca aauugaacuc uuugaaugac aaagaguaga cauuucucuu acugcaaaug     1380

ucaucagaac uuuuugguuu gcagaugaca aaaauucaac ucagacuagu uuaguuaaau     1440

gaggguggug aauauuguuc auauuguggc acaagcaaaa gggugucuga gcccucaaag     1500

ugaggggaaa ccagggccug agccaagcua gaauucccuc ucucugacuc ucaaaucuuu     1560

uagucauuau agauccccca gacuuuacau gacacagcuu uaucaccaga gagggacuga     1620

cacccauguu ucucuggccc caagggaaaa uucccaggga agugcucuga uaggccaagu     1680

uuguaucagg ugcccauccc uggaaggugc uguuauccau ggggaaggga uauauaagau     1740

ggaagcuucc aguccaaucu cauggagaag cagaaauaca uauuuccaag aaguuggaug     1800

gguggguacu auucugauua cacaaaacaa augccacaca ucacccuuac caugugccug     1860

auccagccuc uccccugauu acaccagccu cgucuucauu aagcccucuu ccaucauguc     1920

cccaaaccug caagggcucc ccacugccua cugcaucgag ucaaaacuca aaugcuuggc     1980

uucucauacg uccaccaugg gguccuacca auagauuccc cauugccucc uccuucccaa     2040

aggacuccac ccauccuauc agccugucuc uuccauauga ccucaugcau cuccaccugc     2100

ucccaggcca guaagggaaa uagaaaaacc cugcccccaa auaagaaggg auggauucca     2160

accccaacuc caguagcuug ggacaaauca agcuucaguu uccuggucug uagaagaggg     2220

auaagguacc uuucacauag agaucauccu uuccagcaug aggaacuagc caccaacucu     2280

ugcaggucuc aacccuuuug ucugccucuu agacuucugc uuuccacacc ugcacugcug     2340

ugcugugccc aaguuguggu gcugacaaag cuuggaagag ccugcaggug ccuuggccgc     2400

gugcauagcc cagacacaga agaggcuggu ucuuacgaug gcacccagug agcacuccca     2460

agucuacaga gugauagccu uccguaaccc aacucuccug gacugccuug aauauccccu     2520

cccagucacc uugugcaagc cccugcccau cugggaaaau accccaucau ucaugcuacu     2580

gccaaccugg ggagccaggg cuaugggagc agcuuuuuuu uccccccuag aaacguuugg     2640

aacaauguaa aacuuuaaag cucgaaaaca auuguaauaa ugcuaaagaa aaagucaucc     2700

aaucuaacca caucaauauu gucauuccug uauucacccg uccagaccuu guucacacuc     2760

ucacauguuu agaguugcaa ucguaaugua cagaugguuu uauaaucuga uuuguuuucc     2820

ucuuaacguu agaccacaaa uagugcucgc uuucuaugua guuugguaau uaucauuuua     2880

gaagacucua ccagacugug uauucauuga agucagaugu gguaacuguu aaauugcugu     2940

guaucugaua gcucuuuggc agucuauaug uuuguauaau gaaugagaga auaagucaug     3000

uuccuucaag aucauguacc ccaauuuacu ugccauuacu caauugauaa acauuuaacu     3060

uguuuccaau guuuagcaaa uacauauuuu auagaacuuc                           3100


<210>  28
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  29
<211>  741
<212>  RNA
<213>  Homo sapiens

<400>  29
aaccgagagg cugagacuaa cccagaaaga uccaauucuc aaacugaagc ucgcacucuc       60

gccuccagca ugaaagucuc ugccgcccuu cugugccugc ugcucauagc agccaccuuc      120

auuccccaag ggcucgcuca gccagaugca aucaaugccc cagucaccug cuguuauaac      180

uucaccaaua ggaagaucuc agugcagagg cucgcgagcu auagaagaau caccagcagc      240

aaguguccca aagaagcugu gaucuucaag accauugugg ccaaggagau cugugcugac      300

cccaagcaga aguggguuca ggauuccaug gaccaccugg acaagcaaac ccaaacuccg      360

aagacuugaa cacucacucc acaacccaag aaucugcagc uaacuuauuu uccccuagcu      420

uuccccagac acccuguuuu auuuuauuau aaugaauuuu guuuguugau gugaaacauu      480

augccuuaag uaauguuaau ucuuauuuaa guuauugaug uuuuaaguuu aucuuucaug      540

guacuagugu uuuuuagaua cagagacuug gggaaauugc uuuuccucuu gaaccacagu      600

ucuaccccug ggauguuuug agggucuuug caagaaucau uaauacaaag aauuuuuuuu      660

aacauuccaa ugcauugcua aaauauuauu guggaaauga auauuuugua acuauuacac      720

caaauaaaua uauuuuugua c                                                741


<210>  30
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Lys Val Ser Ala Ala Leu Leu Cys Leu Leu Leu Ile Ala Ala Thr 
1               5                   10                  15      


Phe Ile Pro Gln Gly Leu Ala Gln Pro Asp Ala Ile Asn Ala Pro Val 
            20                  25                  30          


Thr Cys Cys Tyr Asn Phe Thr Asn Arg Lys Ile Ser Val Gln Arg Leu 
        35                  40                  45              


Ala Ser Tyr Arg Arg Ile Thr Ser Ser Lys Cys Pro Lys Glu Ala Val 
    50                  55                  60                  


Ile Phe Lys Thr Ile Val Ala Lys Glu Ile Cys Ala Asp Pro Lys Gln 
65                  70                  75                  80  


Lys Trp Val Gln Asp Ser Met Asp His Leu Asp Lys Gln Thr Gln Thr 
                85                  90                  95      


Pro Lys Thr 
            


<210>  31
<211>  1160
<212>  RNA
<213>  Homo sapiens

<400>  31
ccuccgacag ccucuccaca gguaccauga aggucuccgc ggcacgccuc gcugucaucc       60

ucauugcuac ugcccucugc gcuccugcau cugccucccc auauuccucg gacaccacac      120

ccugcugcuu ugccuacauu gcccgcccac ugccccgugc ccacaucaag gaguauuucu      180

acaccagugg caagugcucc aacccagcag ucgucuuugu cacccgaaag aaccgccaag      240

ugugugccaa cccagagaag aaauggguuc gggaguacau caacucuuug gagaugagcu      300

aggauggaga guccuugaac cugaacuuac acaaauuugc cuguuucugc uugcucuugu      360

ccuagcuugg gaggcuuccc cucacuaucc uaccccaccc gcuccuugaa gggcccagau      420

ucugaccacg acgagcagca guuacaaaaa ccuuccccag gcuggacgug guggcucagc      480

cuuguaaucc cagcacuuug ggaggccaag guggguggau cacuugaggu caggaguucg      540

agacagccug gccaacauga ugaaacccca uguguacuaa aaauacaaaa aauuagccgg      600

gcgugguagc gggcgccugu agucccagcu acucgggagg cugaggcagg agaauggcgu      660

gaacccggga gcggagcuug cagugagccg agaucgcgcc acugcacucc agccugggcg      720

acagagcgag acuccgucuc aaaaaaaaaa aaaaaaaaaa aaaaaauaca aaaauuagcc      780

gcgugguggc ccacgccugu aaucccagcu acucgggagg cuaaggcagg aaaauuguuu      840

gaacccagga gguggaggcu gcagugagcu gagauugugc cacuucacuc cagccugggu      900

gacaaaguga gacuccguca caacaacaac aacaaaaagc uuccccaacu aaagccuaga      960

agagcuucug aggcgcugcu uugucaaaag gaagucucua gguucugagc ucuggcuuug     1020

ccuuggcuuu gcaagggcuc ugugacaagg aaggaaguca gcaugccucu agaggcaagg     1080

aagggaggaa cacugcacuc uuaagcuucc gccgucucaa ccccucacag gagcuuacug     1140

gcaaacauga aaaaucgggg                                                 1160


<210>  32
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Lys Val Ser Ala Ala Ala Leu Ala Val Ile Leu Ile Ala Thr Ala 
1               5                   10                  15      


Leu Cys Ala Pro Ala Ser Ala Ser Pro Tyr Ser Ser Asp Thr Thr Pro 
            20                  25                  30          


Cys Cys Phe Ala Tyr Ile Ala Arg Pro Leu Pro Arg Ala His Ile Lys 
        35                  40                  45              


Glu Tyr Phe Tyr Thr Ser Gly Lys Cys Ser Asn Pro Ala Val Val Phe 
    50                  55                  60                  


Val Thr Arg Lys Asn Arg Gln Val Cys Ala Asn Pro Glu Lys Lys Trp 
65                  70                  75                  80  


Val Arg Glu Tyr Ile Asn Ser Leu Glu Met Ser 
                85                  90      


<210>  33
<211>  3383
<212>  RNA
<213>  Homo sapiens

<400>  33
agaagagcug agacauccgu uccccuacaa gaaacucucc ccggguggaa caagauggau       60

uaucaagugu caaguccaau cuaugacauc aauuauuaua caucggagcc cugccaaaaa      120

aucaauguga agcaaaucgc agcccgccuc cugccuccgc ucuacucacu gguguucauc      180

uuugguuuug ugggcaacau gcuggucauc cucauccuga uaaacugcaa aaggcugaag      240

agcaugacug acaucuaccu gcucaaccug gccaucucug accuguuuuu ccuucuuacu      300

guccccuucu gggcucacua ugcugccgcc cagugggacu uuggaaauac aaugugucaa      360

cucuugacag ggcucuauuu uauaggcuuc uucucuggaa ucuucuucau cauccuccug      420

acaaucgaua gguaccuggc ugucguccau gcuguguuug cuuuaaaagc caggacgguc      480

accuuugggg uggugacaag ugugaucacu uggguggugg cuguguuugc gucucuccca      540

ggaaucaucu uuaccagauc ucaaaaagaa ggucuucauu acaccugcag cucucauuuu      600

ccauacaguc aguaucaauu cuggaagaau uuccagacau uaaagauagu caucuugggg      660

cugguccugc cgcugcuugu cauggucauc ugcuacucgg gaauccuaaa aacucugcuu      720

cggugucgaa augagaagaa gaggcacagg gcugugaggc uuaucuucac caucaugauu      780

guuuauuuuc ucuucugggc ucccuacaac auuguccuuc uccugaacac cuuccaggaa      840

uucuuuggcc ugaauaauug caguagcucu aacagguugg accaagcuau gcaggugaca      900

gagacucuug ggaugacgca cugcugcauc aaccccauca ucuaugccuu ugucggggag      960

aaguucagaa acuaccucuu agucuucuuc caaaagcaca uugccaaacg cuucugcaaa     1020

ugcuguucua uuuuccagca agaggcuccc gagcgagcaa gcucaguuua cacccgaucc     1080

acuggggagc aggaaauauc ugugggcuug ugacacggac ucaagugggc uggugaccca     1140

gucagaguug ugcacauggc uuaguuuuca uacacagccu gggcuggggg ugggguggga     1200

gaggucuuuu uuaaaaggaa guuacuguua uagagggucu aagauucauc cauuuauuug     1260

gcaucuguuu aaaguagauu agaucuuuua agcccaucaa uuauagaaag ccaaaucaaa     1320

auauguugau gaaaaauagc aaccuuuuua ucuccccuuc acaugcauca aguuauugac     1380

aaacucuccc uucacuccga aaguuccuua uguauauuua aaagaaagcc ucagagaauu     1440

gcugauucuu gaguuuagug aucugaacag aaauaccaaa auuauuucag aaauguacaa     1500

cuuuuuaccu aguacaaggc aacauauagg uuguaaaugu guuuaaaaca ggucuuuguc     1560

uugcuauggg gagaaaagac augaauauga uuaguaaaga aaugacacuu uucaugugug     1620

auuuccccuc caagguaugg uuaauaaguu ucacugacuu agaaccaggc gagagacuug     1680

uggccuggga gagcugggga agcuucuuaa augagaagga auuugaguug gaucaucuau     1740

ugcuggcaaa gacagaagcc ucacugcaag cacugcaugg gcaagcuugg cuguagaagg     1800

agacagagcu gguugggaag acauggggag gaaggacaag gcuagaucau gaagaaccuu     1860

gacggcauug cuccgucuaa gucaugagcu gagcagggag auccugguug guguugcaga     1920

agguuuacuc uguggccaaa ggagggucag gaaggaugag cauuuagggc aaggagacca     1980

ccaacagccc ucaggucagg gugaggaugg ccucugcuaa gcucaaggcg ugaggauggg     2040

aaggagggag guauucguaa ggaugggaag gagggaggua uucgugcagc auaugaggau     2100

gcagagucag cagaacuggg guggauuugg uuuggaagug agggucagag aggagucaga     2160

gagaaucccu agucuucaag cagauuggag aaacccuuga aaagacauca agcacagaag     2220

gaggaggagg agguuuaggu caagaagaag auggauuggu guaaaaggau gggucugguu     2280

ugcagagcuu gaacacaguc ucacccagac uccaggcugu cuuucacuga augcuucuga     2340

cuucauagau uuccuuccca ucccagcuga aauacugagg ggucuccagg aggagacuag     2400

auuuaugaau acacgaggua ugaggucuag gaacauacuu cagcucacac augagaucua     2460

ggugaggauu gauuaccuag uagucauuuc auggguuguu gggaggauuc uaugaggcaa     2520

ccacaggcag cauuuagcac auacuacaca uucaauaagc aucaaacucu uaguuacuca     2580

uucagggaua gcacugagca aagcauugag caaagggguc ccauauaggu gagggaagcc     2640

ugaaaaacua agaugcugcc ugcccagugc acacaagugu agguaucauu uucugcauuu     2700

aaccgucaau aggcaaaggg gggaagggac auauucauuu ggaaauaagc ugccuugagc     2760

cuuaaaaccc acaaaaguac aauuuaccag ccuccguauu ucagacugaa uggggguggg     2820

gggggcgccu uagguacuua uuccagaugc cuucuccaga caaaccagaa gcaacagaaa     2880

aaaucgucuc ucccucccuu ugaaaugaau auaccccuua guguuugggu auauucauuu     2940

caaagggaga gagagagguu uuuuucuguu cuuucucaua ugauugugca cauacuugag     3000

acuguuuuga auuuggggga uggcuaaaac caucauagua cagguaaggu gagggaauag     3060

uaagugguga gaacuacuca gggaaugaag gugucagaau aauaagaggu gcuacugacu     3120

uucucagccu cugaauauga acggugagca uuguggcugu cagcaggaag caacgaaggg     3180

aaaugucuuu ccuuuugcuc uuaaguugug gagagugcaa caguagcaua ggacccuacc     3240

cucugggcca agucaaagac auucugacau cuuaguauuu gcauauucuu auguauguga     3300

aaguuacaaa uugcuugaaa gaaaauaugc aucuaauaaa aaacaccuuc uaaaauaaaa     3360

aaaaaaaaaa aaaaaaaaaa aaa                                             3383


<210>  34
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  35
<211>  1635
<212>  RNA
<213>  Homo sapiens

<400>  35
ggcacgaggg cacugagcuc ugccgccugg cucuagccgc cugccuggcc cccgccggga       60

cucuugccca cccucagcca uggcuccgau aucucugucg uggcugcucc gcuuggccac      120

cuucugccau cugacugucc ugcuggcugg acagcaccac ggugugacga aaugcaacau      180

cacgugcagc aagaugacau caaagauacc uguagcuuug cucauccacu aucaacagaa      240

ccaggcauca ugcggcaaac gcgcaaucau cuuggagacg agacagcaca ggcuguucug      300

ugccgacccg aaggagcaau gggucaagga cgcgaugcag caucuggacc gccaggcugc      360

ugcccuaacu cgaaauggcg gcaccuucga gaagcagauc ggcgagguga agcccaggac      420

caccccugcc gccgggggaa uggacgaguc ugugguccug gagcccgaag ccacaggcga      480

aagcaguagc cuggagccga cuccuucuuc ccaggaagca cagagggccc uggggaccuc      540

cccagagcug ccgacgggcg ugacugguuc cucagggacc aggcuccccc cgacgccaaa      600

ggcucaggau ggagggccug ugggcacgga gcuuuuccga gugccucccg ucuccacugc      660

cgccacgugg cagaguucug cuccccacca accugggccc agccucuggg cugaggcaaa      720

gaccucugag gccccgucca cccaggaccc cuccacccag gccuccacug cguccucccc      780

agccccagag gagaaugcuc cgucugaagg ccagcgugug uggggucagg gacagagccc      840

caggccagag aacucucugg agcgggagga gauggguccc gugccagcgc acacggaugc      900

cuuccaggac ugggggccug gcagcauggc ccacgucucu guggucccug ucuccucaga      960

agggaccccc agcagggagc caguggcuuc aggcagcugg accccuaagg cugaggaacc     1020

cauccaugcc accauggacc cccagaggcu gggcguccuu aucacuccug ucccugacgc     1080

ccaggcugcc acccggaggc aggcgguggg gcugcuggcc uuccuuggcc uccucuucug     1140

ccugggggug gccauguuca ccuaccagag ccuccagggc ugcccucgaa agauggcagg     1200

agagauggcg gagggccuuc gcuacauccc ccggagcugu gguaguaauu cauauguccu     1260

ggugcccgug ugaacuccuc uggccugugu cuaguuguuu gauucagaca gcugccuggg     1320

aucccucauc cucauaccca cccccaccca agggccuggc cugagcuggg augauuggag     1380

gggggaggug ggauccucca ggugcacaag cuccaagcuc ccaggcauuc cccaggaggc     1440

cagccuugac cauucuccac cuuccaggga cagagggggu ggccucccaa cucaccccag     1500

ccccaaaacu cuccucugcu gcuggcuggu uagagguucc cuuugacgcc aucccagccc     1560

caaugaacaa uuauuuauua aaugcccagc cccuucugaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaa                                                      1635


<210>  36
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg Arg Gln Ala Val Gly Leu Leu Ala Phe Leu Gly Leu Leu 
            340                 345                 350         


Phe Cys Leu Gly Val Ala Met Phe Thr Tyr Gln Ser Leu Gln Gly Cys 
        355                 360                 365             


Pro Arg Lys Met Ala Gly Glu Met Ala Glu Gly Leu Arg Tyr Ile Pro 
    370                 375                 380                 


Arg Ser Cys Gly Ser Asn Ser Tyr Val Leu Val Pro Val 
385                 390                 395         


<210>  37
<211>  2154
<212>  RNA
<213>  Homo sapiens

<400>  37
ggaauuccgu agugcgaggc cgggcacagc cuuccugugu gguuuuaccg cccagagagc       60

gucauggacc uggggaaacc aaugaaaagc gugcuggugg uggcucuccu ugucauuuuc      120

cagguaugcc ugugucaaga ugaggucacg gacgauuaca ucggagacaa caccacagug      180

gacuacacuu uguucgaguc uuugugcucc aagaaggacg ugcggaacuu uaaagccugg      240

uuccucccua ucauguacuc caucauuugu uucgugggcc uacugggcaa ugggcugguc      300

guguugaccu auaucuauuu caagaggcuc aagaccauga ccgauaccua ccugcucaac      360

cuggcggugg cagacauccu cuuccuccug acccuucccu ucugggccua cagcgcggcc      420

aaguccuggg ucuucggugu ccacuuuugc aagcucaucu uugccaucua caagaugagc      480

uucuucagug gcaugcuccu acuucuuugc aucagcauug accgcuacgu ggccaucguc      540

caggcugucu cagcucaccg ccaccgugcc cgcguccuuc ucaucagcaa gcuguccugu      600

gugggcagcg ccauacuagc cacagugcuc uccaucccag agcuccugua cagugaccuc      660

cagaggagca gcagugagca agcgaugcga ugcucucuca ucacagagca uguggaggcc      720

uuuaucacca uccagguggc ccagauggug aucggcuuuc uggucccccu gcuggccaug      780

agcuucuguu accuugucau cauccgcacc cugcuccagg cacgcaacuu ugagcgcaac      840

aaggccauca aggugaucau cgcugugguc guggucuuca uagucuucca gcugcccuac      900

aauggggugg uccuggccca gacgguggcc aacuucaaca ucaccaguag caccugugag      960

cucaguaagc aacucaacau cgccuacgac gucaccuaca gccuggccug cguccgcugc     1020

ugcgucaacc cuuucuugua cgccuucauc ggcgucaagu uccgcaacga uaucuucaag     1080

cucuucaagg accugggcug ccucagccag gagcagcucc ggcagugguc uuccugucgg     1140

cacauccggc gcuccuccau gaguguggag gccgagacca ccaccaccuu cuccccauag     1200

gcgacucuuc ugccuggacu agagggaccu cucccagggu cccuggggug gggauaggga     1260

gcagaugcaa ugacucagga cauccccccg ccaaaagcug cucaggggaa aaagcagcuc     1320

uccccucaga gugcaagccc cugcuccaga agauagcuuc accccaaucc cagcuaccuc     1380

aaccaaugcc aaaaaaagac agggcugaua agcuaacacc agacagacaa cacugggaaa     1440

cagaggcuau uguccccuaa accaaaaacu gaaagugaaa guccagaaac uguucccacc     1500

ugcuggagug aaggggccaa ggagggugag ugcaaggggc gugggagugg ccugaagagu     1560

ccucugaaug aaccuucugg ccucccacag acucaaaugc ucagaccagc ucuuccgaaa     1620

accaggccuu aucuccaaga ccagagauag uggggagacu ucuuggcuug gugaggaaaa     1680

gcggacauca gcuggucaaa caaacucucu gaaccccucc cuccaucguu uucuucacug     1740

uccuccaagc cagcgggaau ggcagcugcc acgccgcccu aaaagcacac ucauccccuc     1800

acuugccgcg ucgcccuccc aggcucucaa caggggagag ugugguguuu ccugcaggcc     1860

aggccagcug ccuccgcgug aucaaagcca cacucugggc uccagagugg ggaugacaug     1920

cacucagcuc uuggcuccac ugggauggga ggagaggaca agggaaaugu caggggcggg     1980

gagggugaca guggccgccc aaggccacga gcuuguucuu uguucuuugu cacagggacu     2040

gaaaaccucu ccucauguuc ugcuuucgau ucguuaagag agcaacauuu uacccacaca     2100

cagauaaagu uuucccuuga ggaaacaaca gcuuuaaaaa aaaaaaagga auuc           2154


<210>  38
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asp Leu Gly Lys Pro Met Lys Ser Val Leu Val Val Ala Leu Leu 
1               5                   10                  15      


Val Ile Phe Gln Val Cys Leu Cys Gln Asp Glu Val Thr Asp Asp Tyr 
            20                  25                  30          


Ile Gly Asp Asn Thr Thr Val Asp Tyr Thr Leu Phe Glu Ser Leu Cys 
        35                  40                  45              


Ser Lys Lys Asp Val Arg Asn Phe Lys Ala Trp Phe Leu Pro Ile Met 
    50                  55                  60                  


Tyr Ser Ile Ile Cys Phe Val Gly Leu Leu Gly Asn Gly Leu Val Val 
65                  70                  75                  80  


Leu Thr Tyr Ile Tyr Phe Lys Arg Leu Lys Thr Met Thr Asp Thr Tyr 
                85                  90                  95      


Leu Leu Asn Leu Ala Val Ala Asp Ile Leu Phe Leu Leu Thr Leu Pro 
            100                 105                 110         


Phe Trp Ala Tyr Ser Ala Ala Lys Ser Trp Val Phe Gly Val His Phe 
        115                 120                 125             


Cys Lys Leu Ile Phe Ala Ile Tyr Lys Met Ser Phe Phe Ser Gly Met 
    130                 135                 140                 


Leu Leu Leu Leu Cys Ile Ser Ile Asp Arg Tyr Val Ala Ile Val Gln 
145                 150                 155                 160 


Ala Val Ser Ala His Arg His Arg Ala Arg Val Leu Leu Ile Ser Lys 
                165                 170                 175     


Leu Ser Cys Val Gly Ile Trp Ile Leu Ala Thr Val Leu Ser Ile Pro 
            180                 185                 190         


Glu Leu Leu Tyr Ser Asp Leu Gln Arg Ser Ser Ser Glu Gln Ala Met 
        195                 200                 205             


Arg Cys Ser Leu Ile Thr Glu His Val Glu Ala Phe Ile Thr Ile Gln 
    210                 215                 220                 


Val Ala Gln Met Val Ile Gly Phe Leu Val Pro Leu Leu Ala Met Ser 
225                 230                 235                 240 


Phe Cys Tyr Leu Val Ile Ile Arg Thr Leu Leu Gln Ala Arg Asn Phe 
                245                 250                 255     


Glu Arg Asn Lys Ala Ile Lys Val Ile Ile Ala Val Val Val Val Phe 
            260                 265                 270         


Ile Val Phe Gln Leu Pro Tyr Asn Gly Val Val Leu Ala Gln Thr Val 
        275                 280                 285             


Ala Asn Phe Asn Ile Thr Ser Ser Thr Cys Glu Leu Ser Lys Gln Leu 
    290                 295                 300                 


Asn Ile Ala Tyr Asp Val Thr Tyr Ser Leu Ala Cys Val Arg Cys Cys 
305                 310                 315                 320 


Val Asn Pro Phe Leu Tyr Ala Phe Ile Gly Val Lys Phe Arg Asn Asp 
                325                 330                 335     


Leu Phe Lys Leu Phe Lys Asp Leu Gly Cys Leu Ser Gln Glu Gln Leu 
            340                 345                 350         


Arg Gln Trp Ser Ser Cys Arg His Ile Arg Arg Ser Ser Met Ser Val 
        355                 360                 365             


Glu Ala Glu Thr Thr Thr Thr Phe Ser Pro 
    370                 375             


