                         SEQUENCE LISTING

<110>  FRED HUTCHINSON CANCER RESEARCH CENTER
 
<120>  COMPOSITIONS AND METHODS TO PROGRAM THERAPEUTIC CELLS

<130>  F053-0046PCT

<150>  US 62/442,890
<151>  2017-01-05

<150>  US 62/322,581
<151>  2016-04-14

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  887
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  megaTAL protein specific for TCRalpha

<400>  1

Met Gly Ser Cys Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Pro Pro 
1               5                   10                  15      


Lys Lys Lys Arg Lys Val Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln 
            20                  25                  30          


Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val Ala Gln 
        35                  40                  45              


His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His Ile Val 
    50                  55                  60                  


Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val Thr Tyr 
65                  70                  75                  80  


Gln His Ile Ile Thr Ala Leu Pro Glu Ala Thr His Glu Asp Ile Val 
                85                  90                  95      


Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu 
            100                 105                 110         


Thr Asp Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly 
        115                 120                 125             


Gln Leu Val Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Met Glu Ala 
    130                 135                 140                 


Val His Ala Ser Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr 
145                 150                 155                 160 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
                165                 170                 175     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            180                 185                 190         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        195                 200                 205             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    210                 215                 220                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
225                 230                 235                 240 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                245                 250                 255     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            260                 265                 270         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        275                 280                 285             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    290                 295                 300                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
305                 310                 315                 320 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                325                 330                 335     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            340                 345                 350         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        355                 360                 365             


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
    370                 375                 380                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
385                 390                 395                 400 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                405                 410                 415     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
            420                 425                 430         


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        435                 440                 445             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
    450                 455                 460                 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
465                 470                 475                 480 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
                485                 490                 495     


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
            500                 505                 510         


Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp 
        515                 520                 525             


Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys 
    530                 535                 540                 


Leu Gly Gly Arg Pro Ala Met Asp Ala Val Lys Lys Gly Leu Pro His 
545                 550                 555                 560 


Ala Pro Glu Leu Ile Arg Arg Val Asn Arg Arg Ile Gly Glu Arg Thr 
                565                 570                 575     


Ser His Arg Val Ala Ile Ser Arg Val Gly Gly Ser Ser Arg Arg Glu 
            580                 585                 590         


Ser Ile Asn Pro Trp Ile Leu Thr Gly Phe Ala Asp Ala Glu Gly Ser 
        595                 600                 605             


Phe Ile Leu Asp Ile Arg Asn Arg Asn Asn Glu Ser Asn Arg Tyr Arg 
    610                 615                 620                 


Thr Ser Leu Arg Phe Gln Ile Thr Leu His Asn Lys Asp Lys Ser Ile 
625                 630                 635                 640 


Leu Glu Asn Ile Gln Ser Thr Trp Lys Val Gly Lys Ile Thr Asn Ser 
                645                 650                 655     


Gly Asp Arg Ala Val Met Leu Arg Val Thr Arg Phe Glu Asp Leu Lys 
            660                 665                 670         


Val Ile Ile Asp His Phe Glu Lys Tyr Pro Leu Ile Thr Gln Lys Leu 
        675                 680                 685             


Gly Asp Tyr Lys Leu Phe Lys Gln Ala Phe Ser Val Met Glu Asn Lys 
    690                 695                 700                 


Glu His Leu Lys Glu Asn Gly Ile Lys Glu Leu Val Arg Ile Lys Ala 
705                 710                 715                 720 


Lys Met Asn Trp Gly Leu Thr Asp Glu Leu Lys Lys Ala Phe Pro Glu 
                725                 730                 735     


Asn Ile Ser Lys Glu Arg Pro Leu Ile Asn Lys Asn Ile Pro Asn Phe 
            740                 745                 750         


Lys Trp Leu Ala Gly Phe Thr Ser Gly Asp Gly Tyr Phe Gly Val Asn 
        755                 760                 765             


Leu Lys Lys Val Lys Gly Asn Ala Lys Val Tyr Val Gly Leu Arg Phe 
    770                 775                 780                 


Ser Ile Ser Gln His Ile Arg Asp Lys Asn Leu Met Asn Ser Leu Ile 
785                 790                 795                 800 


Thr Tyr Leu Gly Cys Gly Ser Ile Trp Glu Lys Asn Lys Ser Glu Phe 
                805                 810                 815     


Ser Trp Leu Glu Phe Val Val Thr Lys Phe Ser Asp Ile Asn Asp Lys 
            820                 825                 830         


Ile Ile Pro Val Phe Gln Glu Asn Thr Leu Ile Gly Val Lys Leu Glu 
        835                 840                 845             


Asp Phe Glu Asp Trp Cys Lys Val Ala Lys Leu Ile Glu Glu Lys Lys 
    850                 855                 860                 


His Leu Thr Glu Ser Gly Leu Asp Glu Ile Lys Lys Ile Lys Leu Asn 
865                 870                 875                 880 


Met Asn Lys Gly Arg Val Phe 
                885         


<210>  2
<211>  2464
<212>  DNA
<213>  Homo sapiens

<400>  2
actctaaaac gagaagtaca agtgagttcc cccaaggggt cggccgcgcc tcttcctgtc       60

cccgccctgc cggctgcccc aggccagtgg agtggcagcc ccagaactgg gaccaccggg      120

ggtggtgagg cggcccggca ctgggagctg catctgaggc ttagtccctg agctctctgc      180

ctgcccagac tagctgcacc tcctcattcc ctgcgccccc ttcctctccg gaagccccca      240

ggatggtgag gtggtttcac cgagacctca gtgggctgga tgcagagacc ctgctcaagg      300

gccgaggtgt ccacggtagc ttcctggctc ggcccagtcg caagaaccag ggtgacttct      360

cgctctccgt cagggtgggg gatcaggtga cccatattcg gatccagaac tcaggggatt      420

tctatgacct gtatggaggg gagaagtttg cgactctgac agagctggtg gagtactaca      480

ctcagcagca gggtgtcctg caggaccgcg acggcaccat catccacctc aagtacccgc      540

tgaactgctc cgatcccact agtgagaggt ggtaccatgg ccacatgtct ggcgggcagg      600

cagagacgct gctgcaggcc aagggcgagc cctggacgtt tcttgtgcgt gagagcctca      660

gccagcctgg agacttcgtg ctttctgtgc tcagtgacca gcccaaggct ggcccaggct      720

ccccgctcag ggtcacccac atcaaggtca tgtgcgaggg tggacgctac acagtgggtg      780

gtttggagac cttcgacagc ctcacggacc tggtggagca tttcaagaag acggggattg      840

aggaggcctc aggcgccttt gtctacctgc ggcagccgta ctatgccacg agggtgaatg      900

cggctgacat tgagaaccga gtgttggaac tgaacaagaa gcaggagtcc gaggatacag      960

ccaaggctgg cttctgggag gagtttgaga gtttgcagaa gcaggaggtg aagaacttgc     1020

accagcgtct ggaagggcag cggccagaga acaagggcaa gaaccgctac aagaacattc     1080

tcccctttga ccacagccga gtgatcctgc agggacggga cagtaacatc cccgggtccg     1140

actacatcaa tgccaactac atcaagaacc agctgctagg ccctgatgag aacgctaaga     1200

cctacatcgc cagccagggc tgtctggagg ccacggtcaa tgacttctgg cagatggcgt     1260

ggcaggagaa cagccgtgtc atcgtcatga ccacccgaga ggtggagaaa ggccggaaca     1320

aatgcgtccc atactggccc gaggtgggca tgcagcgtgc ttatgggccc tactctgtga     1380

ccaactgcgg ggagcatgac acaaccgaat acaaactccg taccttacag gtctccccgc     1440

tggacaatgg agacctgatt cgggagatct ggcattacca gtacctgagc tggcccgacc     1500

atggggtccc cagtgagcct gggggtgtcc tcagcttcct ggaccagatc aaccagcggc     1560

aggaaagtct gcctcacgca gggcccatca tcgtgcactg cagcgccggc atcggccgca     1620

caggcaccat cattgtcatc gacatgctca tggagaacat ctccaccaag ggcctggact     1680

gtgacattga catccagaag accatccaga tggtgcgggc gcagcgctcg ggcatggtgc     1740

agacggaggc gcagtacaag ttcatctacg tggccatcgc ccagttcatt gaaaccacta     1800

agaagaagct ggaggtcctg cagtcgcaga agggccagga gtcggagtac gggaacatca     1860

cctatccccc agccatgaag aatgcccatg ccaaggcctc ccgcacctcg tccaagagct     1920

tggagtctag tgcagggacc gtggctgcgt cacctgtgag acggggtggc cagaggggac     1980

tgccagtgcc gggtccccct gtgctgtctc ctgacctgca ccaactgcct gtacttgccc     2040

ccctgcaccc ggctgcagac acaaggagga tgtgtatgag aacctgcaca ctaagaacaa     2100

gagggaggag aaagtgaaga agcagcggtc agcagacaag gagaagagca agggttccct     2160

caagaggaag tgagcggtgc tgtcctcagg tggccatgcc tcagccctga ccctgtggaa     2220

gcatttcgcg atggacagac tcacaacctg aacctaggag tgccccattc ttttgtaatt     2280

taaatggctg catccccccc acctctccct gaccctgtat atagcccagc caggccccag     2340

gcagggccaa cccttctcct cttgtaaata aagccctggg atcactgtga aaaaaaaaaa     2400

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2460

aaaa                                                                  2464


<210>  3
<211>  867
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  4
<211>  420
<212>  DNA
<213>  Homo sapiens

<400>  4
atgacatcca ttcgagctgt atttatattc ctgtggctgc agctggactt ggtgaatgga       60

gagaatgtgg agcagcatcc ttcaaccctg agtgtccagg agggagacag cgctgttatc      120

aagtgtactt attcagacag tgcctcaaac tacttccctt ggtataagca agaacttgga      180

aaaagacctc agcttattat agacattcgt tcaaatgtgg gcgaaaagaa agaccaacga      240

attgctgtta cattgaacaa gacagccaaa catttctccc tgcacatcac agagacccaa      300

cctgaagact cggctgtcta cttctgtgca gcaagtagga aggactctgg gggttaccag      360

aaagttacct ttggaactgg aacaaagctc caagtcatcc caaatatcca gaaccctgac      420


<210>  5
<211>  1027
<212>  DNA
<213>  Homo sapiens

<400>  5
ttggattatc aagtgtcaag tccaatctat gacatcaatt attatacatc ggagccctgc       60

caaaaaatca atgtgaagca aatcgcagcc cgcctcctgc ctccgctcta ctcactggtg      120

ttcatctttg gttttgtggg caacatgctg gtcatcctca tcctgataaa ctgcaaaagg      180

ctgaagagca tgactgacat ctacctgctc aacctggcca tctctgacct gtttttcctt      240

cttactgtcc ccttctgggc tcactatgct gccgcccagt gggactttgg aaatacaatg      300

tgtcaactct tgacagggct ctattttata ggcttcttct ctggaatctt cttcatcatc      360

ctcctgacaa tcgataggta cctggctgtc gtccatgctg tgtttgcttt aaaagccagg      420

acggtcacct ttggggtggt gacaagtgtg atcacttggg tggtggctgt gtttgcgtct      480

ctcccaggaa tcatctttac cagatctcaa aaagaaggtc ttcattacac ctgcagctct      540

cattttccat acattaaaga tagtcatctt ggggctggtc ctgccgctgc ttgtcatggt      600

catctgctac tcgggaatcc taaaaactct gcttcggtgt cgaaatgaga agaagaggca      660

cagggctgtg aggcttatct tcaccatcat gattgtttat tttctcttct gggctcccta      720

caacattgtc cttctcctga acaccttcca ggaattcttt ggcctgaata attgcagtag      780

ctctaacagg ttggaccaag ctatgcaggt gacagagact cttgggatga cgcactgctg      840

catcaacccc atcatctatg cctttgtcgg ggagaagttc agaaactacc tcttagtctt      900

cttccaaaag cacattgcca aacgcttctg caaatgctgt tctattttcc agcaagaggc      960

tcccgagcga gcaagctcag tttacacccg atccactggg gagcaggaaa tatctgtggg     1020

cttgtga                                                               1027


<210>  6
<211>  1912
<212>  DNA
<213>  Homo sapiens

<400>  6
ttttttttct tccctctagt gggcggggca gaggagttag ccaagatgtg actttgaaac       60

cctcagcgtc tcagtgccct tttgttctaa acaaagaatt ttgtaattgg ttctaccaaa      120

gaaggatata atgaagtcac tatgggaaaa gatggggagg agagttgtag gattctacat      180

taattctctt gtgcccttag cccactactt cagaatttcc tgaagaaagc aagcctgaat      240

tggtttttta aattgcttta aaaatttttt ttaactgggt taatgcttgc tgaattggaa      300

gtgaatgtcc attcctttgc ctcttttgca gatatacact tcagataact acaccgagga      360

aatgggctca ggggactatg actccatgaa ggaaccctgt ttccgtgaag aaaatgctaa      420

tttcaataaa atcttcctgc ccaccatcta ctccatcatc ttcttaactg gcattgtggg      480

caatggattg gtcatcctgg tcatgggtta ccagaagaaa ctgagaagca tgacggacaa      540

gtacaggctg cacctgtcag tggccgacct cctctttgtc atcacgcttc ccttctgggc      600

agttgatgcc gtggcaaact ggtactttgg gaacttccta tgcaaggcag tccatgtcat      660

ctacacagtc aacctctaca gcagtgtcct catcctggcc ttcatcagtc tggaccgcta      720

cctggccatc gtccacgcca ccaacagtca gaggccaagg aagctgttgg ctgaaaaggt      780

ggtctatgtt ggcgtctgga tccctgccct cctgctgact attcccgact tcatctttgc      840

caacgtcagt gaggcagatg acagatatat ctgtgaccgc ttctacccca atgacttgtg      900

ggtggttgtg ttccagtttc agcacatcat ggttggcctt atcctgcctg gtattgtcat      960

cctgtcctgc tattgcatta tcatctccaa gctgtcacac tccaagggcc accagaagcg     1020

caaggccctc aagaccacag tcatcctcat cctggctttc ttcgcctgtt ggctgcctta     1080

ctacattggg atcagcatcg actccttcat cctcctggaa atcatcaagc aagggtgtga     1140

gtttgagaac actgtgcaca agtggatttc catcaccgag gccctagctt tcttccactg     1200

ttgtctgaac cccatcctct atgctttcct tggagccaaa tttaaaacct ctgcccagca     1260

cgcactcacc tctgtgagca gagggtccag cctcaagatc ctctccaaag gaaagcgagg     1320

tggacattca tctgtttcca ctgagtctga gtcttcaagt tttcactcca gctaacacag     1380

atgtaaaaga ctttttttta tacgataaat aacttttttt taagttacac atttttcaga     1440

tataaaagac tgaccaatat tgtacagttt ttattgcttg ttggattttt gtcttgtgtt     1500

tctttagttt ttgtgaagtt taattgactt atttatataa attttttttg tttcatattg     1560

atgtgtgtct aggcaggacc tgtggccaag ttcttagttg ctgtatgtct cgtggtagga     1620

ctgtagaaaa gggaactgaa cattccagag cgtgtagtga atcacgtaaa gctagaaatg     1680

atccccagct gtttatgcat agataatctc tccattcccg tggaacgttt ttcctgttct     1740

taagacgtga ttttgctgta gaagatggca cttataacca aagcccaaag tggtatagaa     1800

atgctggttt ttcagttttc aggagtgggt tgatttcagc acctacagtg tacagtcttg     1860

tattaagttg ttaataaaag tacatgttaa acttaaaaaa aaaaaaaaaa aa             1912


<210>  7
<211>  2413
<212>  DNA
<213>  Homo sapiens

<400>  7
ttccgtcctt ccgtccgcgg ccctgtcagc tggagcgcgg cgcaggctct gccccggccc       60

ggcggctctg gccggccgtc cagtccgtgc ggcggacccc gaggagcctc gatgtggatg      120

gccccgcgaa gttaagttct gggctcgcgc ttccactccg ccgcgccttc ctcccagttt      180

ccgtccgctc gccgcaccgg cttcgttccc ccaaatctcg gaccgtccct tcgcgccccc      240

tccccgtccg cccccagtgc tgcgttctcc ccctcttggc tctcctgcgg ctgggggagg      300

ggcgggggtc accatggccg aggcgcctca ggtggtggag atcgacccgg acttcgagcc      360

gctgccccgg ccgcgctcgt gcacctggcc gctgcccagg ccggagttta gccagtccaa      420

ctcggccacc tccagcccgg cgccgtcggg cagcgcggct gccaaccccg acgccgcggc      480

gggcctgccc tcggcctcgg ctgccgctgt cagcgccgac ttcatgagca acctgagctt      540

gctggaggag agcgaggact tcccgcaggc gcccggctcc gtggcggcgg cggtggcggc      600

ggcggccgcc gcggccgcca ccggggggct gtgcggggac ttccagggcc cggaggcggg      660

ctgcctgcac ccagcgccac cgcagccccc gccgcccggg ccgctgtcgc agcacccgcc      720

ggtgcccccc gccgccgctg ggccgctcgc ggggcagccg cgcaagagca gctcgtcccg      780

ccgcaacgcg tggggcaacc tgtcctacgc cgacctcatc accaaggcca tcgagagctc      840

ggcggagaag cggctcacgc tgtcgcagat ctacgagtgg atggtcaaga gcgtgcccta      900

cttcaaggat aagggtgaca gcaacagctc ggcgggctgg aagaattcaa ttcgtcataa      960

tctgtcccta cacagcaagt tcattcgtgt gcagaatgaa ggaactggaa aaagttcttg     1020

gtggatgctc aatccagagg gtggcaagag cgggaaatct cctaggagaa gagctgcatc     1080

catggacaac aacagtaaat ttgctaagag ccgaagccga gctgccaaga agaaagcatc     1140

tctccagtct ggccaggagg gtgctgggga cagccctgga tcacagtttt ccaaatggcc     1200

tgcaagccct ggctctcaca gcaatgatga ctttgataac tggagtacat ttcgccctcg     1260

aactagctca aatgctagta ctattagtgg gagactctca cccattatga ccgaacagga     1320

tgatcttgga gaaggggatg tgcattctat ggtgtacccg ccatctgccg caaagatggc     1380

ctctacttta cccagtctgt ctgagataag caatcccgaa aacatggaaa atcttttgga     1440

taatctcaac cttctctcat caccaacatc attaactgtt tcgacccagt cctcacctgg     1500

caccatgatg cagcagacgc cgtgctactc gtttgcgcca ccaaacacca gtttgaattc     1560

acccagccca aactaccaaa aatatacata tggccaatcc agcatgagcc ctttgcccca     1620

gatgcctata caaacacttc aggacaataa gtcgagttat ggaggtatga gtcagtataa     1680

ctgtgcgcct ggactcttga aggagttgct gacttctgac tctcctcccc ataatgacat     1740

tatgacacca gttgatcctg gggtagccca gcccaacagc cgggttctgg gccagaacgt     1800

catgatgggc cctaattcgg tcatgtcaac ctatggcagc caggcatctc ataacaaaat     1860

gatgaatccc agctcccata cccaccctgg acatgctcag cagacatctg cagttaacgg     1920

gcgtcccctg ccccacacgg taagcaccat gccccacacc tcgggtatga accgcctgac     1980

ccaagtgaag acacctgtac aagtgcctct gccccacccc atgcagatga gtgccctggg     2040

gggctactcc tccgtgagca gctgcaatgg ctatggcaga atgggccttc tccaccagga     2100

gaagctccca agtgacttgg atggcatgtt cattgagcgc ttagactgtg acatggaatc     2160

catcattcgg aatgacctca tggatggaga tacattggat tttaactttg acaatgtgtt     2220

gcccaaccaa agcttcccac acagtgtcaa gacaacgaca catagctggg tgtcaggctg     2280

agggttagtg agcaggttac acttaaaagt acttcagatt gtctgacagc aggaactgag     2340

agaagcagtc caaagatgtc tttcaccaac tcccttttag ttttctcggt taaaaaaaaa     2400

aaaaaaaaaa aaa                                                        2413


<210>  8
<211>  3286
<212>  DNA
<213>  Homo sapiens

<400>  8
gcgtgtcggg cgcggaaggg ggaggcggcc cggggcgccc gcgagtgagg cgcggggcgg       60

cgaagggagc gcgggtggcg gcacttgctg ccgcggcctt ggatgggctg ggcccccctc      120

gccgctccgc ctcctccaca cgcgcggcgg ccgcggcgag ggggacgcgc cgcccggggc      180

ccggcacctt cgggaacccc ccggcccgga gcctgcggcc tgcgccgcct cggccgccgg      240

gagccccgtg gagcccccgc cgccgcgccg ccccgcggac cggacgctga gggcactcgg      300

ggcggggcgc gcgctcgggc agacgtttgc ggggaggggg gcgcctgccg ggccccggcg      360

accaccttgg gggtcgcggg ccggctcggg gggcgcccag tgcgggccct cgcgggcgcc      420

gggcagcgac cagccctgag cggagctgtt ggccgcggcg ggaggcctcc cggacgcccc      480

cagccccccg aacgctcgcc cgggccggcg ggagtcggcg ccccccggga ggtccgctcg      540

gtcgtccgcg gcggagcgtt tgctcctggg acaggcggtg ggaccggggc gtcgccggag      600

acgcccccag cgaagttggg ctctccaggt gtgggggtcc cggggggtag cgacgtcgcg      660

gacccggcct gtgggatggg cggcccggag aagactgcgc tcggccgtgt tcatacttgt      720

ccgtgggcct gaggtccccg gaggatgacc tagcactgaa aagccccggc cggcctcccc      780

agggtccccg aggacgaagt tgaccctgac cgggccgtct cccagttctg aggcccgggt      840

cccactggaa ctcgcgtctg agccgccgtc ccggaccccc ggtgcccgcc ggtccgcaga      900

ccctgcaccg ggcttggact cgcagccggg actgacgtgt agaacaatcg tttctgttgg      960

aagaagggtt tttcccttcc ttttggggtt tttgttgcct tttttttttc ttttttcttt     1020

gtaaaatttt ggagaaggga agtcggaaca caaggaagga ccgctcaccc gcggactcag     1080

ggctggcggc gggactccag gaccctgggt ccagcatgga ggtggtggac ccgcagcagc     1140

tgggcatgtt cacggagggc gagctgatgt cggtgggtat ggacacgttc atccaccgca     1200

tcgactccac cgaggtcatc taccagccgc gccgcaagcg ggccaagctc atcggcaagt     1260

acctgatggg ggacctgctg ggggaaggct cttacggcaa ggtgaaggag gtgctggact     1320

cggagacgct gtgcaggagg gccgtcaaga tcctcaagaa gaagaagttg cgaaggatcc     1380

ccaacgggga ggccaacgtg aagaaggaaa ttcaactact gaggaggtta cggcacaaaa     1440

atgtcatcca gctggtggat gtgttataca acgaagagaa gcagaaaatg tatatggtga     1500

tggagtactg cgtgtgtggc atgcaggaaa tgctggacag cgtgccggag aagcgtttcc     1560

cagtgtgcca ggcccacggg tacttctgtc agctgattga cggcctggag tacctgcata     1620

gccagggcat tgtgcacaag gacatcaagc cggggaacct gctgctcacc accggtggca     1680

ccctcaaaat ctccgacctg ggcgtggccg aggcactgca cccgttcgcg gcggacgaca     1740

cctgccggac cagccagggc tccccggctt tccagccgcc cgagattgcc aacggcctgg     1800

acaccttctc cggcttcaag gtggacatct ggtcggctgg ggtcaccctc tacaacatca     1860

ccacgggtct gtaccccttc gaaggggaca acatctacaa gttgtttgag aacatcggga     1920

aggggagcta cgccatcccg ggcgactgtg gccccccgct ctctgacctg ctgaaaggga     1980

tgcttgagta cgaaccggcc aagaggttct ccatccggca gatccggcag cacagctggt     2040

tccggaagaa acatcctccg gctgaagcac cagtgcccat cccaccgagc ccagacacca     2100

aggaccggtg gcgcagcatg actgtggtgc cgtacttgga ggacctgcac ggcgcggacg     2160

aggacgagga cctcttcgac atcgaggatg acatcatcta cactcaggac ttcacggtgc     2220

ccggacaggt cccagaagag gaggccagtc acaatggaca gcgccggggc ctccccaagg     2280

ccgtgtgtat gaacggcaca gaggcggcgc agctgagcac caaatccagg gcggagggcc     2340

gggcccccaa ccctgcccgc aaggcctgct ccgccagcag caagatccgc cggctgtcgg     2400

cctgcaagca gcagtgaggc tggccgcctg cagcccgtgt ccaggagccc cgccaggtgc     2460

ccgcgccagg ccctcagtct tcctgccggt tccgcccgcc ctcccggaga ggtggccgcc     2520

atgcttctgt gccgaccacg ccccaggacc tccggagcgc cctgcagggc cgggcagggg     2580

gacagcaggg accgggcgca gccctccccc ctcggccgcc cggcagtgca cgcggcttgt     2640

tgacttcgca gccccgggcg gagccttccc gggcgggcgt gggaggaggg aggcggcctc     2700

catgcacttt atgtggagac tactggcccc gcccgtggcc tcgtgctccg cagggcgccc     2760

agcgccgtcc ggcggccccg ccgcagacca gctggcgggt gtggagacca ggctcctgac     2820

cccgccatgc atgcagcgcc acctggaagc cgcgcggccg ctttggtttt ttgtttggtt     2880

ggttccattt tctttttttc tttttttttt taagaaaaaa taaaaggtgg atttgagctg     2940

tggctgtgag gggtgtttgg gagctgctgg gtggcagggg ggctgtgggg tcgggctcac     3000

gtcgcggccg cctttgcgct ctcgggtcac cctgctttgg cggcccggcc ggagggcagg     3060

accctcacct ctcccccaag gccactgcgc tcttgggacc ccagagaaaa cccggagcaa     3120

gcaggagtgt gcggtcaata tttatatcat ccagaaaaga aaaacacgag aaacgccatc     3180

gcgggatggt gcagacgcgg cggggactcg gagggtgccg tgcgggcgag gccgcccaaa     3240

tttggcaata aataaagctt gggaagcttg gacctgaaaa aaaaaa                    3286


<210>  9
<211>  6767
<212>  DNA
<213>  Homo sapiens

<400>  9
aagtttccaa gtggtcaact tgaccgatgc tttggcaatt gaaaaagggc agaaaggcgc       60

gggctagtgg gtggatgggg acaaagatct aagtcacctt cttccagcgt gtgagcctgg      120

gaggagggtg ggggtcctga ggagcaagag gtacgaggaa ggaaaaggag agggcttctg      180

ggttagtttc cacctcctgc tttccaactc acggcgcttt ccttccggaa aggacgctgg      240

attcagggcg cgccagtacg cgcagtagcg gcccgcgagt cggcaggtgg gtagccccgg      300

cgcgggagga aggggaagtt accttcccct cggaagaggg cgctggctcc cccatcctgc      360

ctttataata aggccaccgg aggagaggaa gcagccagct gccgtctgcg ctttgcaaag      420

catgcagtta ggggagcagc tcttggtgag ctcagtgaac ctgcctggcg cgcacttcta      480

cccgctggag agtgcgcgag gcggcagcgg cgggagcgct ggccacctcc ccagcgcggc      540

cccctctcct cagaagttgg acttagacaa agcgtccaag aagttttccg gcagtctctc      600

ctgcgaggcg gtgagcgggg agcccgcagc cgccagcgca ggggcccccg cggccatgct      660

tagtgacacc gacgccgggg acgcatttgc cagcgctgcg gcagtggcca agccggggcc      720

cccggacggc cgcaagggct ccccctgcgg ggaggaggag ctgccctccg ccgctgcagc      780

cgccgccgcc gccgccgccg cggctgcggc cactgcgcgc tactccatgg acagcctgag      840

ctccgagcgg tactacctcc agtcccccgg tcctcagggg tcggagctgg ctgcgccctg      900

ctcactcttc ccgtaccagg cggcggctgg ggcgccccac ggacctgtgt acccggctcc      960

taacggggcg cgctacccct acggctccat gctgcccccc ggcggcttcc ccgcggctgt     1020

gtgcccaccc gggagggcgc agttcggccc aggagccggt gcgggcagtg gcgcgggcgg     1080

tagcagcggc gggggcggcg gcccgggcac ctatcagtac agccaggggg ctccgctcta     1140

cgggccgtac cctggagccg cagcggcggg atcttgcgga ggactggggg gcctgggggt     1200

tccaggttct ggcttccgtg cccacgtcta cctgtgcaac cggcctctgt ggctcaaatt     1260

ccaccgccac caaactgaga tgatcattac gaaacagggc aggtgagcgc agcgtggagg     1320

ggcccctggg ttcggggata aagggtgacg tgtggtcctg gggaaggtcc gggatgaggg     1380

agctgaaccc agttgttccg cgcggtgctt agagtgtttc accgcgcgca ataaatctcc     1440

gtagacaccg catctccaat gcggtgtccc tctgtgtcag tgccccggcg gctcttgcag     1500

ggtgccaatg ttacggctgt acaccgcttt tccctcccat catcctcacc tgaacagacc     1560

tggaggaggc ggaaatggaa attagggcat gtccacaagc tggattcgtt agatcctcct     1620

gctcggcggt atgcttgtgc atgcctgcat gccggcaagg agccacggat agggaaggct     1680

caagagctgg ccacctgagc gcagtagatg ggctcccgca gttttaggcg ccagggtctc     1740

cacggggcgt ctccgggagg tgggcatgaa ggctagagcg ccggcctcgg aagctcggtc     1800

ggagtaggtg gttagatctg ccctggagcc agacctggct cgggttcggt gcgcgagaaa     1860

gttctgatat acatccaact gctaacactg gctacttctg gggaaaggga ggggtgggtg     1920

ctgagagagg ggcactcaaa ggggactttt agcctaaagt tttaatatat atttttaaca     1980

agaataacct aatattgttc tctggtactt ttcaaaatgg tgcatttaaa aattagtagt     2040

ttttaacatt ctaggagaaa aattttaaga gcgtctgaaa gggccgagaa tatgagcctt     2100

cggaagcacg cgcgaatttg gaatataccg atgttggggc aagctttttt tttttttttt     2160

tttttttttt tttttttttt ttttgaaaag acggaaaggt tccaagagtt gccaactcaa     2220

aaatatttta catagtttca gaccacttga tctaccagca ttctgttcac tgcaaacttt     2280

taaatgtgtt ccgaccctat cccaggtgtc tggggaaccc gctggggcct gggcctgttc     2340

taggacatcc caattaaaat cgatttttct gattctattc ccttgcacag gcgcatgttt     2400

cctttcttga gcttcaacat aaacggactc aatcccactg cccactacaa tgtgttcgta     2460

gaggtggtgc tggcggaccc caaccactgg cgcttccagg ggggcaaatg ggtgacctgt     2520

ggcaaagccg acaataacat gcagggtgag cagagaagag gctcgggccg gggaggaacg     2580

ggcgggaaga aatcgtaacc ctcgactcac acaactcaca tttaaatgta gcactttttt     2640

tttccccttc cattctgagg cctagaggtg ttagtatgag tgtctttgag ttgcttgttt     2700

gacggagagg agagtttgct aagtcagatt tcttgtctgc caatatgtag atatttagaa     2760

cctttaacta agacatcacc ccacccccca atccctacgt ttaacaaatc agtagtcata     2820

agctctccag gtgggaaggg ctcctgggat tctaatgttc acttgagaaa gcccagccaa     2880

agtttagttc acccataaat atccaactgt cttccatcgg atgttgccct tacagcttta     2940

gaaggcccca aattgacctt caagagtcat ctcttgttag ctccgtttct aaattctgaa     3000

atgccattca ggggagtccc tagtgcaagg aaggttggaa gcacaggggc ctgggaggga     3060

tatggatgta gtcctgctgg tctccactgg cctctttaag caacttttac tgggagacca     3120

actgtaagtc tagctcttat atcttgctca tagctaagag acatccctcc gctttctcca     3180

tttgtaaaca gccctatatg cttgggtttt gtgttttgtt tcattttctc ttaggcaaca     3240

aaatgtatgt tcacccagag tctcctaata ctggttccca ctggatgaga caggagattt     3300

cattcgggaa attaaaactc accaataaca aaggcgcaaa taacaacaac acccaggtag     3360

agtgacagag caggagggga tatcttctgg ctttgactat aaggcttttt tctaataaga     3420

gtccctactc ttttcactgt atttataata tttgcatttg tgacctgttt gctcgcctat     3480

ttctaaccat ttttgttctt ttgacctttc tcatcttcac tttcttattg gatttcgata     3540

acagtgagtt gactattaag aacagaaata gcgaagtatt ttgggaattt aggaaaccaa     3600

gaggaaagca tatctatcac aaccacatac ccagctatga tttaaatttc aaaaaaaaag     3660

tgggggggca ataatgagac ctttaaactt gcaataaaca aagctgttag tgaggagcat     3720

ttagaagtcc aataccaaaa tacataattt gtcaaaatct aattttgttg aaccactaag     3780

aggcttttta gatttagcaa tttttttctg tactctttcc agatgatagt cttacaatcc     3840

ttacacaaat accaaccccg actgcatatt gttgaagtta cagaggatgg cgtggaggac     3900

ttgaatgagc cctcaaagac ccagactttt accttctcag aaacgcaatt cattgcagtg     3960

actgcctacc aaaacaccga tgtgagtgtc ccagacatct caagaatctc taaagctaag     4020

gtccagcatg ataaatcact caatgactgt ttttctcccc tatctagatt actcaactaa     4080

agattgatca taaccccttt gcaaaaggct tcagagacaa ctatgattcg taagtgcagc     4140

ttttatccac acttgcctga tcatctctga gcaggacata catcaacagg cactttgctg     4200

ataatgtatt ttaggaagag cttttacctt tgggattttt acatattttt ctttttccaa     4260

aattttttcc tttactaatc ttgctttaga tttttctcag aaaggttgtg ttaatttctg     4320

aagaaatgtt aaggacttaa aaatgaagag gtttttttag catttgagtg aagatttgaa     4380

attttaagaa tctgcattta tatatacctt tcttttcatt tgatccattt ttttatcctc     4440

ccaagagcag atattattac tctcccccac ccccactttt ttttttaaca taagaaaaaa     4500

ctgaaactaa gaggatgtaa tttcacaaca cgaaatagca aggccctgct ctttttaaaa     4560

tctgagtttt ctaccgccac agccagtgtt ttttccatca cattgacaaa ggaggtttga     4620

tctgagtttt tcgtgttcta ggactagtaa aggtagattt tctatagttt aaatacttga     4680

tgcctaggag gaaacttttt cttgcatggt gggaaatttt tcccaataag ccaagagtcc     4740

agctaaaatg ggccagtgca tctcctgcct ctgttctttc agcccaacag accagcactt     4800

tcggtgtaga taaccaacac aagccttttt catttctggg aggtggtttg tttggggaca     4860

acattagggt tttttttttt ttttaagtgt ttctctttat attgtagcat gtacaccgct     4920

tcagaaaatg acaggttaac tccatctccc acggattctc ctagatccca tcagattgtc     4980

cctggaggtc ggtacggcgt tcaatccttc ttcccggagc cctttgtcaa cactttacct     5040

caagcccgct attataatgg cgagagaacc gtgccacaga ccaacggcct cctttcaccc     5100

caacagagcg aagaggtggc caaccctccc cagcggtggc ttgtcacgcc tgtccagcaa     5160

cctgggacca acaaactaga catcagttcc tatgaatctg aatatacttc tagcacattg     5220

ctcccatatg gcattaaatc cttgcccctt cagacatccc atgccctggg gtattaccca     5280

gacccaacct ttcctgcaat ggcagggtgg ggaggtcgag gttcttacca gaggaagatg     5340

gcagctggac taccatggac ctccagaaca agccccactg tgttctctga agatcagctc     5400

tccaaggaga aagtgaaaga ggaaattggc tcttcttgga tagagacacc cccttccatc     5460

aaatctctag attccaatga ttcaggagta tacaccagtg cttgtaagcg aaggcggctg     5520

tctcctagca actccagtaa tgaaaattca ccctccataa agtgtgagga cattaatgct     5580

gaagagtata gtaaagacac ctcaaaaggc atgggagggt attatgcttt ttacacaact     5640

ccctaaagag ttattttaac ctcaaaaatt agctaacttt ttgcagatgg acttggtggt     5700

gttttttgtt gtcttctttg cctaggttgc caaaaagatg tttgccttcc accttgatgc     5760

atcctgtttt gtgcaattct ctaaaagaag gtgccaaagc tttttgattg ctgcaggtaa     5820

ctgaaacaaa cctagcattt ttaaaaaata agattaatgg aagactttaa ggtattttaa     5880

aattcgaagg gtatccaagg ttctgtattt atttattggg gagacactaa cccttcaaag     5940

aagcaggctg tgaacattgg gtgcccagtg ctatcagatg agttaaaacc tttgattctc     6000

atttctattt gtaaattctt aagcaaatag aagccgagtg ttaaggtgtt ttgcttctga     6060

aagagggctg tgccttccgt ttcagaagga gacattttgc tgttacattc tgccaggggc     6120

aaaagatact aggcccagga gtcaagaaaa gcttttgtga aagtgatagt ttcacctgac     6180

tttgattcct taacccccgg cttttggaac aagccatgtt tgccctagtc caggattgcc     6240

tcacttgaga cttgctaggc ctctgctgtg tgctggggtg gccagtggga ctcaggagag     6300

agcaagctaa ggagtcacca aaaaaaaaaa aaaaaaaaag ggagaattta aaagtgtaca     6360

gttgtgtgtt tagatacact atagaataat gtggtatata ttgtacaaat agtctacata     6420

ggtgtctggg ataatgtaaa actggtgctt tggctttgta aagaatttgc aaatcactta     6480

acagctgcag gggcaagggg agagtttcat catccccatg atatttggga atattctgtt     6540

tacttcttag atagttaaga atgtattcag ctactatgta ctaacttgaa ccgtgtttaa     6600

ggaaaactcc tatttcatcc tcttcttgcg ccatcccctc tccctaactt ggtaatgtga     6660

agaaactaaa acctgatacc acagctccta taggcatttt agagatcttg gatttttatg     6720

tacagtctta gtcattttta ataaatgtgg ttcagtaagg gaacgga                   6767


<210>  10
<211>  2471
<212>  DNA
<213>  Homo sapiens

<400>  10
ggggacgaag ggaagctcca gcgtgtggcc ccggcgagtg cggataaaag ccgccccgcc       60

gggctcgggc ttcattctga gccgagcccg gtgccaagcg cagctagctc agcaggcggc      120

agcggcggcc tgagcttcag ggcagccagc tccctcccgg tctcgccttc cctcgcggtc      180

agcatgaaag ccttcagtcc cgtgaggtcc gttaggaaaa acagcctgtc ggaccacagc      240

ctgggcatct cccggagcaa aacccctgtg gacgacccga tgagcctgct atacaacatg      300

aacgactgct actccaagct caaggagctg gtgcccagca tcccccagaa caagaaggtg      360

agcaagatgg aaatcctgca gcacgtcatc gactacatct tggacctgca gatcgccctg      420

gactcgcatc ccactattgt cagcctgcat caccagagac ccgggcagaa ccaggcgtcc      480

aggacgccgc tgaccaccct caacacggat atcagcatcc tgtccttgca ggtaagacct      540

gctccggggt ccccgccccg ccgccgcaca ctcccgcggt cgtctgggct gtcactagga      600

gatccgtagc ccagacggtg actttcgtat gagctattta actttatttt cttcagaatc      660

tgctgtagat tgagctgtgc gtgaaattgc tagtaagttc tgacatgtta atgcgtctgt      720

ctttaaatct gaattgttac cataaacgtg tttaatggaa cttgctggtc tgtggactac      780

aaaaaaaaaa aaaaaaaaaa aaaaaccctt tctacttaac attgtcttaa cctcgtactc      840

tttatcctct ttctttccag gcttctgaat tcccttctga gttaatgtca aatgacagca      900

aagcactgtg tggctgaata agcggtgagt gtttgcttgt gccacccgtg ggtaaactgc      960

ccctcggtgt gtgtgcgcgc gcgcgcatgt gtttttgctt gtgtatctat aaaatgtctg     1020

atttggtaaa tgcatgctta cttcgcggtg ttacccgtac tacattgtct cactagacat     1080

gaaggagctt gtagctttgg gtgctcgaga tcacagaaca ttttccttta aaaggaaatg     1140

atgccaataa cttactacga aggcggccga ggaacgtgtg tattggcttt gtagcaaatg     1200

taatgccctg gatcttccta cgagtcctct ggtactatga ggtactaacc tccactgtaa     1260

ttaatcttac cgccacaaat tccatagtga tcctccttcc ctaaaactat agtcctctgg     1320

gattctctgg gctagttgag gattgctacc ctgtgccttc aaccctgtga tgtgggatcc     1380

cagacttccc tatctgttaa ctaaagggct gttttcaatc aaataattgt tacgagaagc     1440

agactggcgc ctgtagcact gctgttggag atccaaatag gagattgggt tgggaagttt     1500

ttcccttgag tctctgctat tttaatgttt aatttgcgct gtcgaggcga gtgtgtgtgt     1560

tgcatctgga cgccagggtt tgcccaatct ttgagtgttt ggttaaatgt tcaaactgtg     1620

gcttcctccc ggcgccagtc gcccgcctct gcccttaggt tacattctct taaacatgcc     1680

tttctccccc actctttcgc aggtgttcat gatttctttt attctttgca caacaacaac     1740

aacaacaaat tcacggaatc ttttaagtgc tgaacttatt tttcaaccat ttcacaagga     1800

ggacaagttg aatggacctt tttaaaaaga aaaaaaaaat ggaaggaaaa ctaagaatga     1860

tcatcttccc agggtgttct cttacttgga ctgtgatatt cgttatttat gaaaaagact     1920

tttaaatgcc ctttctgcag ttggaaggtt ttctttatat actattccca ccatggggag     1980

cgaaaacgtt aaaatcacaa ggaattgccc aatctaagca gactttgcct tttttcaaag     2040

gtggagcgtg aataccagaa ggatccagta ttcagtcact taaatgaagt cttttggtca     2100

gaaattacct ttttgacaca agcctactga atgctgtgta tatatttata tataaatata     2160

tctatttgag tgaaaccttg tgaactcttt aattagagtt ttcttgtata gtggcagaga     2220

tgtctatttc tgcattcaaa agtgtaatga tgtacttatt catgctaaac tttttataaa     2280

agtttagttg taaacttaac ccttttatac aaaataaatc aagtgtgttt attgaatggt     2340

gattgcctgc tttatttcag aggaccagtg ctttgatttt tattatgcta tgttataact     2400

gaacccaaat aaatacaagt tcaaatttat gtagactgta taagattata ataaaacatg     2460

tctgaagtca a                                                          2471


<210>  11
<211>  4018
<212>  DNA
<213>  Homo sapiens

<400>  11
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat       60

gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt      120

gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg      180

cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga      240

cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt      300

ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt      360

cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag      420

ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct      480

gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct      540

ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc      600

cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg      660

ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc      720

gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg      780

cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag      840

gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga      900

agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg      960

ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg     1020

tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct     1080

gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt     1140

ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg     1200

cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc     1260

gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc     1320

agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga     1380

ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt     1440

gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag     1500

gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc     1560

caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg     1620

caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct     1680

ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt     1740

ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg     1800

gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct     1860

gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact     1920

ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg     1980

agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact     2040

gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct     2100

gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga     2160

cccgccgcct gagctgtact ttgtcaaggt ggatgtgacg ggcgcgtacg acaccatccc     2220

ccaggacagg ctcacggagg tcatcgccag catcatcaaa ccccagaaca cgtactgcgt     2280

gcgtcggtat gccgtggtcc agaaggccgc ccatgggcac gtccgcaagg ccttcaagag     2340

ccacgtctct accttgacag acctccagcc gtacatgcga cagttcgtgg ctcacctgca     2400

ggagaccagc ccgctgaggg atgccgtcgt catcgagcag agctcctccc tgaatgaggc     2460

cagcagtggc ctcttcgacg tcttcctacg cttcatgtgc caccacgccg tgcgcatcag     2520

gggcaagtcc tacgtccagt gccaggggat cccgcagggc tccatcctct ccacgctgct     2580

ctgcagcctg tgctacggcg acatggagaa caagctgttt gcggggattc ggcgggacgg     2640

gctgctcctg cgtttggtgg atgatttctt gttggtgaca cctcacctca cccacgcgaa     2700

aaccttcctc aggaccctgg tccgaggtgt ccctgagtat ggctgcgtgg tgaacttgcg     2760

gaagacagtg gtgaacttcc ctgtagaaga cgaggccctg ggtggcacgg cttttgttca     2820

gatgccggcc cacggcctat tcccctggtg cggcctgctg ctggataccc ggaccctgga     2880

ggtgcagagc gactactcca gctatgcccg gacctccatc agagccagtc tcaccttcaa     2940

ccgcggcttc aaggctggga ggaacatgcg tcgcaaactc tttggggtct tgcggctgaa     3000

gtgtcacagc ctgtttctgg atttgcaggt gaacagcctc cagacggtgt gcaccaacat     3060

ctacaagatc ctcctgctgc aggcgtacag gtttcacgca tgtgtgctgc agctcccatt     3120

tcatcagcaa gtttggaaga accccacatt tttcctgcgc gtcatctctg acacggcctc     3180

cctctgctac tccatcctga aagccaagaa cgcagggatg tcgctggggg ccaagggcgc     3240

cgccggccct ctgccctccg aggccgtgca gtggctgtgc caccaagcat tcctgctcaa     3300

gctgactcga caccgtgtca cctacgtgcc actcctgggg tcactcagga cagcccagac     3360

gcagctgagt cggaagctcc cggggacgac gctgactgcc ctggaggccg cagccaaccc     3420

ggcactgccc tcagacttca agaccatcct ggactgatgg ccacccgccc acagccaggc     3480

cgagagcaga caccagcagc cctgtcacgc cgggctctac gtcccaggga gggaggggcg     3540

gcccacaccc aggcccgcac cgctgggagt ctgaggcctg agtgagtgtt tggccgaggc     3600

ctgcatgtcc ggctgaaggc tgagtgtccg gctgaggcct gagcgagtgt ccagccaagg     3660

gctgagtgtc cagcacacct gccgtcttca cttccccaca ggctggcgct cggctccacc     3720

ccagggccag cttttcctca ccaggagccc ggcttccact ccccacatag gaatagtcca     3780

tccccagatt cgccattgtt cacccctcgc cctgccctcc tttgccttcc acccccacca     3840

tccaggtgga gaccctgaga aggaccctgg gagctctggg aatttggagt gaccaaaggt     3900

gtgccctgta cacaggcgag gaccctgcac ctggatgggg gtccctgtgg gtcaaattgg     3960

ggggaggtgc tgtgggagta aaatactgaa tatatgagtt tttcagtttt gaaaaaaa       4018


<210>  12
<211>  2335
<212>  DNA
<213>  Homo sapiens

<400>  12
gttattctct ggaacatgaa acattctgtt gtgctcatat catgcaaatt atcactagta       60

ggagagcaga gagtggaaat gttccaggta taaagaccca caagataaag aagctcagag      120

tcgttagaaa caggagcaga tgtacagggt ttgcctgact cacactcaag gttgcataag      180

caagatttca aaattaatcc tattctggag acctcaaccc aatgtacaat gttcctgact      240

ggaaaagaag aactatattt ttctgatttt ttttttcaaa tctttaccat tagttgccct      300

gtatctccgc cttcactttc tgcaggaaac tttatttcct acttctgcat gccaagtttc      360

tacctctaga tctgtttggt tcagttgctg agaagcctga cataccagga ctgcctgaga      420

caagccacaa gctgaacaga gaaagtggat tgaacaagga cgcatttccc cagtacatcc      480

acaacatgct gtccacatct cgttctcggt ttatcagaaa taccaacgag agcggtgaag      540

aagtcaccac cttttttgat tatgattacg gtgctccctg tcataaattt gacgtgaagc      600

aaattggggc ccaactcctg cctccgctct actcgctggt gttcatcttt ggttttgtgg      660

gcaacatgct ggtcgtcctc atcttaataa actgcaaaaa gctgaagtgc ttgactgaca      720

tttacctgct caacctggcc atctctgatc tgctttttct tattactctc ccattgtggg      780

ctcactctgc tgcaaatgag tgggtctttg ggaatgcaat gtgcaaatta ttcacagggc      840

tgtatcacat cggttatttt ggcggaatct tcttcatcat cctcctgaca atcgatagat      900

acctggctat tgtccatgct gtgtttgctt taaaagccag gacggtcacc tttggggtgg      960

tgacaagtgt gatcacctgg ttggtggctg tgtttgcttc tgtcccagga atcatcttta     1020

ctaaatgcca gaaagaagat tctgtttatg tctgtggccc ttattttcca cgaggatgga     1080

ataatttcca cacaataatg aggaacattt tggggctggt cctgccgctg ctcatcatgg     1140

tcatctgcta ctcgggaatc ctgaaaaccc tgcttcggtg tcgaaacgag aagaagaggc     1200

atagggcagt gagagtcatc ttcaccatca tgattgttta ctttctcttc tggactccct     1260

ataatattgt cattctcctg aacaccttcc aggaattctt cggcctgagt aactgtgaaa     1320

gcaccagtca actggaccaa gccacgcagg tgacagagac tcttgggatg actcactgct     1380

gcatcaatcc catcatctat gccttcgttg gggagaagtt cagaaggtat ctctcggtgt     1440

tcttccgaaa gcacatcacc aagcgcttct gcaaacaatg tccagttttc tacagggaga     1500

cagtggatgg agtgacttca acaaacacgc cttccactgg ggagcaggaa gtctcggctg     1560

gtttataaaa cgaggagcag tttgattgtt gtttataaag ggagataaca atctgtatat     1620

aacaacaaac ttcaagggtt tgttgaacaa tagaaacctg taaagcaggt gcccaggaac     1680

ctcagggctg tgtgtactaa tacagactat gtcacccaat gcatatccaa catgtgctca     1740

gggaataatc cagaaaaact gtgggtagag actttgactc tccagaaagc tcatctcagc     1800

tcctgaaaaa tgcctcatta ccttgtgcta atcctctttt tctagtcttc ataatttctt     1860

cactcaatct ctgattctgt caatgtcttg aaatcaaggg ccagctggag gtgaagaaga     1920

gaatgtgaca ggcacagatg aatgggagtg agggatagtg gggtcagggc tgagaggaga     1980

aggagggaga catgagcatg gctgagcctg gacaaagaca aaggtgagca aagggctcac     2040

gcattcagcc aggagatgat actggtcctt agccccatct gccacgtgta tttaaccttg     2100

aagggttcac caggtcaggg agagtttggg aactgcaata acctgggagt tttggtggag     2160

tccgatgatt ctcttttgca taagtgcatg acatattttt gctttattac agtttatcta     2220

tggcacccat gcaccttaca tttgaaatct atgaaatatc atgctccatt gttcagatgc     2280

ttcttaggcc acatccccct gtctaaaaat tcagaaaatt tttgtttata aaaga          2335


<210>  13
<211>  1657
<212>  DNA
<213>  Homo sapiens

<400>  13
tctcacagga agccacgcac ccttgaaagg caccgggtcc ttcttagcat cgtgcttcct       60

gagcaagcct ggcattgcct cacagacctt cctcagagcc gctttcagaa aagcaagctg      120

cttctggttg ggcccagacc tgccttgagg agcctgtaga gttaaaaaat gaaccccacg      180

gatatagcag acaccaccct cgatgaaagc atatacagca attactatct gtatgaaagt      240

atccccaagc cttgcaccaa agaaggcatc aaggcatttg gggagctctt cctgccccca      300

ctgtattcct tggtttttgt atttggtctg cttggaaatt ctgtggtggt tctggtcctg      360

ttcaaataca agcggctcag gtccatgact gatgtgtacc tgctcaacct tgccatctcg      420

gatctgctct tcgtgttttc cctccctttt tggggctact atgcagcaga ccagtgggtt      480

tttgggctag gtctgtgcaa gatgatttcc tggatgtact tggtgggctt ttacagtggc      540

atattctttg tcatgctcat gagcattgat agatacctgg caattgtgca cgcggtgttt      600

tccttgaggg caaggacctt gacttatggg gtcatcacca gtttggctac atggtcagtg      660

gctgtgttcg cctcccttcc tggctttctg ttcagcactt gttatactga gcgcaaccat      720

acctactgca aaaccaagta ctctctcaac tccacgacgt ggaaggttct cagctccctg      780

gaaatcaaca ttctcggatt ggtgatcccc ttagggatca tgctgttttg ctactccatg      840

atcatcagga ccttgcagca ttgtaaaaat gagaagaaga acaaggcggt gaagatgatc      900

tttgccgtgg tggtcctctt ccttgggttc tggacacctt acaacatagt gctcttccta      960

gagaccctgg tggagctaga agtccttcag gactgcacct ttgaaagata cttggactat     1020

gccatccagg ccacagaaac tctggctttt gttcactgct gccttaatcc catcatctac     1080

ttttttctgg gggagaaatt tcgcaagtac atcctacagc tcttcaaaac ctgcaggggc     1140

ctttttgtgc tctgccaata ctgtgggctc ctccaaattt actctgctga cacccccagc     1200

tcatcttaca cgcagtccac catggatcat gatctccatg atgctctgta gaaaaatgaa     1260

atggtgaaat gcagagtcaa tgaactttcc acattcagag cttacttaaa attgtatttt     1320

agtaagagat tcctgagcca gtgtcaggag gaaggcttac acccacagtg gaaagacagc     1380

ttctcatcct gcaggcagct ttttctctcc cactagacaa gtccagcctg gcaagggttc     1440

acctgggctg aggcatcctt cctcacacca ggcttgcctg caggcatgag tcagtctgat     1500

gagaactctg agcagtgctt gaatgaagtt gtaggtaata ttgcaaggca aagactattc     1560

ccttctaacc tgaactgatg ggtttctcca gagggaattg cagagtactg gctgatggag     1620

taaatcgcta ccttttgctg tggcaaatgg gccctct                              1657


<210>  14
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  15
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Lys Ala Val Leu Leu Ala Leu Leu Met Ala Gly Leu Ala Leu Gln 
1               5                   10                  15      


Pro Gly Thr Ala Leu Leu Cys Tyr Ser Cys Lys Ala Gln Val Ser Asn 
            20                  25                  30          


Glu Asp Cys Leu Gln Val Glu Asn Cys Thr Gln Leu Gly Glu Gln Cys 
        35                  40                  45              


Trp Thr Ala Arg Ile Arg Ala Val Gly Leu Leu Thr Val Ile Ser Lys 
    50                  55                  60                  


Gly Cys Ser Leu Asn Cys Val Asp Asp Ser Gln Asp Tyr Tyr Val Gly 
65                  70                  75                  80  


Lys Lys Asn Ile Thr Cys Cys Asp Thr Asp Leu Cys Asn Ala Ser Gly 
                85                  90                  95      


Ala His Ala Leu Gln Pro Ala Ala Ala Ile Leu Ala Leu Leu Pro Ala 
            100                 105                 110         


Leu Gly Leu Leu Leu Trp Gly Pro Gly Gln Leu 
        115                 120             


<210>  16
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Leu Pro Thr Ala Arg Pro Leu Leu Gly Ser Cys Gly Thr Pro 
1               5                   10                  15      


Ala Leu Gly Ser Leu Leu Phe Leu Leu Phe Ser Leu Gly Trp Val Gln 
            20                  25                  30          


Pro Ser Arg Thr Leu Ala Gly Glu Thr Gly Gln Glu Ala Ala Pro Leu 
        35                  40                  45              


Asp Gly Val Leu Ala Asn Pro Pro Asn Ile Ser Ser Leu Ser Pro Arg 
    50                  55                  60                  


Gln Leu Leu Gly Phe Pro Cys Ala Glu Val Ser Gly Leu Ser Thr Glu 
65                  70                  75                  80  


Arg Val Arg Glu Leu Ala Val Ala Leu Ala Gln Lys Asn Val Lys Leu 
                85                  90                  95      


Ser Thr Glu Gln Leu Arg Cys Leu Ala His Arg Leu Ser Glu Pro Pro 
            100                 105                 110         


Glu Asp Leu Asp Ala Leu Pro Leu Asp Leu Leu Leu Phe Leu Asn Pro 
        115                 120                 125             


Asp Ala Phe Ser Gly Pro Gln Ala Cys Thr His Phe Phe Ser Arg Ile 
    130                 135                 140                 


Thr Lys Ala Asn Val Asp Leu Leu Pro Arg Gly Ala Pro Glu Arg Gln 
145                 150                 155                 160 


Arg Leu Leu Pro Ala Ala Leu Ala Cys Trp Gly Val Arg Gly Ser Leu 
                165                 170                 175     


Leu Ser Glu Ala Asp Val Arg Ala Leu Gly Gly Leu Ala Cys Asp Leu 
            180                 185                 190         


Pro Gly Arg Phe Val Ala Glu Ser Ala Glu Val Leu Leu Pro Arg Leu 
        195                 200                 205             


Val Ser Cys Pro Gly Pro Leu Asp Gln Asp Gln Gln Glu Ala Ala Arg 
    210                 215                 220                 


Ala Ala Leu Gln Gly Gly Gly Pro Pro Tyr Gly Pro Pro Ser Thr Trp 
225                 230                 235                 240 


Ser Val Ser Thr Met Asp Ala Leu Arg Gly Leu Leu Pro Val Leu Gly 
                245                 250                 255     


Gln Pro Ile Ile Arg Ser Ile Pro Gln Gly Ile Val Ala Ala Trp Arg 
            260                 265                 270         


Gln Arg Ser Ser Arg Asp Pro Ser Trp Arg Gln Pro Glu Arg Thr Ile 
        275                 280                 285             


Leu Arg Pro Arg Phe Arg Arg Glu Val Glu Lys Thr Ala Cys Pro Ser 
    290                 295                 300                 


Gly Lys Lys Ala Arg Glu Ile Asp Glu Ser Leu Ile Phe Tyr Lys Lys 
305                 310                 315                 320 


Trp Glu Leu Glu Ala Cys Val Asp Ala Ala Leu Leu Ala Thr Gln Met 
                325                 330                 335     


Asp Arg Val Asn Ala Ile Pro Phe Thr Tyr Glu Gln Leu Asp Val Leu 
            340                 345                 350         


Lys His Lys Leu Asp Glu Leu Tyr Pro Gln Gly Tyr Pro Glu Ser Val 
        355                 360                 365             


Ile Gln His Leu Gly Tyr Leu Phe Leu Lys Met Ser Pro Glu Asp Ile 
    370                 375                 380                 


Arg Lys Trp Asn Val Thr Ser Leu Glu Thr Leu Lys Ala Leu Leu Glu 
385                 390                 395                 400 


Val Asn Lys Gly His Glu Met Ser Pro Gln Val Ala Thr Leu Ile Asp 
                405                 410                 415     


Arg Phe Val Lys Gly Arg Gly Gln Leu Asp Lys Asp Thr Leu Asp Thr 
            420                 425                 430         


Leu Thr Ala Phe Tyr Pro Gly Tyr Leu Cys Ser Leu Ser Pro Glu Glu 
        435                 440                 445             


Leu Ser Ser Val Pro Pro Ser Ser Ile Trp Ala Val Arg Pro Gln Asp 
    450                 455                 460                 


Leu Asp Thr Cys Asp Pro Arg Gln Leu Asp Val Leu Tyr Pro Lys Ala 
465                 470                 475                 480 


Arg Leu Ala Phe Gln Asn Met Asn Gly Ser Glu Tyr Phe Val Lys Ile 
                485                 490                 495     


Gln Ser Phe Leu Gly Gly Ala Pro Thr Glu Asp Leu Lys Ala Leu Ser 
            500                 505                 510         


Gln Gln Asn Val Ser Met Asp Leu Ala Thr Phe Met Lys Leu Arg Thr 
        515                 520                 525             


Asp Ala Val Leu Pro Leu Thr Val Ala Glu Val Gln Lys Leu Leu Gly 
    530                 535                 540                 


Pro His Val Glu Gly Leu Lys Ala Glu Glu Arg His Arg Pro Val Arg 
545                 550                 555                 560 


Asp Trp Ile Leu Arg Gln Arg Gln Asp Asp Leu Asp Thr Leu Gly Leu 
                565                 570                 575     


Gly Leu Gln Gly Gly Ile Pro Asn Gly Tyr Leu Val Leu Asp Leu Ser 
            580                 585                 590         


Val Gln Glu Ala Leu Ser Gly Thr Pro Cys Leu Leu Gly Pro Gly Pro 
        595                 600                 605             


Val Leu Thr Val Leu Ala Leu Leu Leu Ala Ser Thr Leu Ala 
    610                 615                 620         


<210>  17
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  18
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  19
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  19

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  20
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly His His His His His His His His His His Ser Ser Gly His 
1               5                   10                  15      


Ile Glu Gly Arg His Met Arg Arg Val Pro Gly Val Ala Pro Thr Leu 
            20                  25                  30          


Val Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys Ala 
        35                  40                  45              


Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met 
    50                  55                  60                  


His Ser Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys 
65                  70                  75                  80  


Asp Cys Glu Arg Arg Phe Phe Arg Ser Asp Gln Leu Lys Arg His Gln 
                85                  90                  95      


Arg Arg His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg 
            100                 105                 110         


Lys Phe Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His Thr 
        115                 120                 125             


Gly Glu Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe 
    130                 135                 140                 


Ala Arg Ser Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn 
145                 150                 155                 160 


Met Thr Lys Leu Gln Leu Ala Leu 
                165             


<210>  21
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  21

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu 
                245                 250                 255     


Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala 
            260                 265                 270         


Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser 
        275                 280                 285             


Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu 
    290                 295                 300                 


Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu 
305                 310                 315                 320 


Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp 
                325                 330                 335     


Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
            340                 345         


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFV CDRL1

<400>  22

Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu Asn 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFV  CDRL2

<400>  23

Ser Arg Leu His Ser Gly Val 
1               5           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFV  CDRL3

<400>  24

Gly Asn Thr Leu Pro Tyr Thr Phe Gly 
1               5                   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFV  CDRH1

<400>  25

Asp Tyr Gly Val Ser 
1               5   


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFV  CDRH2

<400>  26

Val Thr Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFV  CDRH3

<400>  27

Tyr Ala Met Asp Tyr Trp Gly 
1               5           


<210>  28
<211>  734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv (VH-VL) FMC63

<400>  28
cacatccaga tgacccagac cacctccagc ctgagcgcca gcctgggcga ccgggtgacc       60

atcagctgcc gggccagcca ggacatcagc aagtacctga actggtatca gcagaagccc      120

gacggcaccg tcaagctgct gatctaccac accagccggc tgcacagcgg cgtgcccagc      180

cggtttagcg gcagcggctc cggcaccgac tacagcctga ccatctccaa cctggaacag      240

gaagatatcg ccacctactt ttgccagcag ggcaacacac tgccctacac ctttggcggc      300

ggaacaaagc tggaaatcac cggcagcacc tccggcagcg gcaagcctgg cagcggcgag      360

ggcagcacca agggcgaggt gaagctgcag gaaagcggcc ctggcctggt ggcccccagc      420

cagagcctga gcgtgacctg caccgtgagc ggcgtgagcc tgcccgacta cggcgtgagc      480

tggatccggc agccccccag gaagggcctg gaatggctgg gcgtgatctg gggcagcgag      540

accacctact acaacagcgc cctgaagagc cggctgacca tcatcaagga caacagcaag      600

agccaggtgt tcctgaagat gaacagcctg cagaccgacg acaccgccat ctactactgc      660

gccaagcact actactacgg cggcagctac gccatggact actggggcca gggcaccagc      720

gtgaccgtga gcag                                                        734


<210>  29
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19 scFv (VH-VL) FMC63

<400>  29

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Ser Thr Ser Gly 
            100                 105                 110         


Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu Val Lys 
        115                 120                 125             


Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser 
    130                 135                 140                 


Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile 
                165                 170                 175     


Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu 
            180                 185                 190         


Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn 
        195                 200                 205             


Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr 
    210                 215                 220                 


Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFV CDRL1

<400>  30

Ala Ser Gly Phe Asp Phe Ser Ala Tyr Tyr Met 
1               5                   10      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFV CDRL2

<400>  31

Thr Ile Tyr Pro Ser Ser Gly 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFV CDRL3

<400>  32

Ala Asp Arg Ala Thr Tyr Phe Cys Ala 
1               5                   


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFV CDRH1

<400>  33

Asp Thr Ile Asp Trp Tyr 
1               5       


<210>  34
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFV CDRH2

<400>  34

Val Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg 
1               5                   10                  15      


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-ROR1 scFV CDRH3

<400>  35

Tyr Ile Gly Gly Tyr Val Phe Gly 
1               5               


<210>  36
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  36
cggagcaagc ggagcagagg cggccacagc gactacatga acatgacccc cagacggcct       60

ggccccaccc ggaagcacta ccagccctac gccccaccca gggactttgc cgcctacaga      120

agc                                                                    123


<210>  37
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P28z CAR

<400>  37
gtggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc tgaggtgcag ctgcagcagt caggacctga actggtgaag      120

cctgggactt cagtgaggat atcctgcaag acttctggat acacattcac tgaatatacc      180

atacactggg tgaagcagag ccatggaaag agccttgagt ggattggaaa catcaatcct      240

aacaatggtg gtaccaccta caatcagaag ttcgaggaca aggccacatt gactgtagac      300

aagtcctcca gtacagccta catggagctc cgcagcctaa catctgagga ttctgcagtc      360

tattattgtg cagctggttg gaactttgac tactggggcc aagggaccac ggtcaccgtc      420

tcctcaggtg gaggtggatc aggtggaggt ggatctggtg gaggtggatc tgacattgtg      480

atgacccagt ctcacaaatt catgtccaca tcagtaggag acagggtcag catcatctgt      540

aaggccagtc aagatgtggg tactgctgta gactggtatc aacagaaacc aggacaatct      600

cctaaactac tgatttattg ggcatccact cggcacactg gagtccctga tcgcttcaca      660

ggcagtggat ctgggacaga cttcactctc accattacta atgttcagtc tgaagacttg      720

gcagattatt tctgtcagca atataacagc tatcccctca cgttcggtgc tgggaccatg      780

ctggacctga aacgggcggc cgcatctact actaccaagc cagtgctgcg aactccctca      840

cctgtgcacc ctaccgggac atctcagccc cagagaccag aagattgtcg gccccgtggc      900

tcagtgaagg ggaccggatt ggacttcgcc tgtgatattt acatctgggc acccttggcc      960

ggaatctgcg tggcccttct gctgtccttg atcatcactc tcatctgcta caatagtaga     1020

aggaacagac tccttcaaag tgactacatg aacatgactc cccggaggcc tgggctcact     1080

cgaaagcctt accagcccta cgcccctgcc agagactttg cagcgtaccg ccccagagca     1140

aaattcagca ggagtgcaga gactgctgcc aacctgcagg accccaacca gctctacaat     1200

gagctcaatc tagggcgaag agaggaatat gacgtcttgg agaagaagcg ggctcgggat     1260

ccagagatgg gaggcaaaca gcagaggagg aggaaccccc aggaaggcgt atacaatgca     1320

ctgcagaaag acaagatggc agaagcctac agtgagatcg gcacaaaagg cgagaggcgg     1380

agaggcaagg ggcacgatgg cctttaccag ggtctcagca ctgccaccaa ggacacctat     1440

gatgccctgc atatgcagac cctggcccct cgctaa                               1476


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  39
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   IgG4-Fc

<400>  39

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  40
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-CH2-CH3

<400>  40

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge-CH3

<400>  41

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  42
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge only

<400>  42

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  43
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  44
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cytoplasmic domain of CD28 with LL to GG substitution

<400>  44

Arg Ser Lys Arg Ser Arg Gly Gly His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  45
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  45

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  46
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  46

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  47
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A ribosomal skip element

<400>  47

Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro Arg 
            20                  


<210>  48
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tEGFR

<400>  48

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Gln His Gly Gln Phe Ser Leu Ala Val 
        115                 120                 125             


Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile 
    130                 135                 140                 


Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala 
145                 150                 155                 160 


Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr 
                165                 170                 175     


Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln 
            180                 185                 190         


Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro 
        195                 200                 205             


Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val 
    210                 215                 220                 


Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn 
225                 230                 235                 240 


Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn 
                245                 250                 255     


Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His 
            260                 265                 270         


Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met 
        275                 280                 285             


Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val 
    290                 295                 300                 


Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly 
305                 310                 315                 320 


Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr 
                325                 330                 335     


Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile 
            340                 345                 350         


Gly Leu Phe Met 
        355     


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STREP TAG II

<400>  49

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  50

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  51
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  51

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  52

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC-Forward

<400>  53
cccgtgtcat tctctggact                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TRAC-Reverse

<400>  54
atcacgagca gctggtttct                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foxo13A Forward

<400>  55
ggacagccta gaaagagcag                                                   20


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foxo13A Probe

<400>  56
aggtcggcgt agctcagatt gc                                                22


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foxo13A Reverse

<400>  57
ctcttgacca tccactcgta g                                                 21


