﻿               SEQUENCE LISTING

<110> Eberhard Karls Universität Tübingen - Medizinische Fakultät

<120> Targeted mRNA for in vivo application

<130> 5402P561WO

<150> EP 16 166 310.9
<151> 2016-04-21

<160> 7

<170> BiSSAP 1.3

<210> 1
<211> 86
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD4 Aptamer

<400> 1
gggagacaag aataaacgct caatgacgtc cttagaattg cgcattcctc acacaggatc     60

ttttcgacag gaggctcaca acaggc                                          86


<210> 2
<211> 2170
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD19-CD28-CD3-zeta construct

<400> 2
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg      60

atcccagaca tccagatgac acagactaca tcctccctgt ctgcctctct gggagacaga     120

gtcaccatca gttgcagggc aagtcaggac attagtaaat atttaaattg gtatcagcag     180

aaaccagatg gaactgttaa actcctgatc taccatacat caagattaca ctcaggagtc     240

ccatcaaggt tcagtggcag tgggtctgga acagattatt ctctcaccat tagcaacctg     300

gagcaagaag atattgccac ttacttttgc caacagggta atacgcttcc gtacacgttc     360

ggagggggga ctaagttgga aataacaggc tccacctctg gatccggcaa gcccggatct     420

ggcgagggat ccaccaaggg cgaggtgaaa ctgcaggagt caggacctgg cctggtggcg     480

ccctcacaga gcctgtccgt cacatgcact gtctcagggg tctcattacc cgactatggt     540

gtaagctgga ttcgccagcc tccacgaaag ggtctggagt ggctgggagt aatatggggt     600

agtgaaacca catactataa ttcagctctc aaatccagac tgaccatcat caaggacaac     660

tccaagagcc aagttttctt aaaaatgaac agtctgcaaa ctgatgacac agccatttac     720

tactgtgcca aacattatta ctacggtggt agctatgcta tggactactg gggtcaagga     780

acctcagtca ccgtctcctc agtagcagat cccgccgagc ccaaatctcc tgacaaaact     840

cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc     900

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     960

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag    1020

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgggtggtc    1080

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc    1140

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc    1200

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc    1260

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc    1320

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc    1380

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc    1440

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg    1500

tctccgggta aaaaagatcc caaattttgg gtgctggtgg tggttggtgg agtcctggct    1560

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc    1620

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag    1680

cattaccagc cctatgcccc cccacgcgac ttcgcagcct atcgctccct gagagtgaag    1740

ttcagcagga gcgcagacgc ccccgcgtac cagcagggcc agaaccagct ctataacgag    1800

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct    1860

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag    1920

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc    1980

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc    2040

cttcacatgc aggccctgcc ccctcgctaa tcctcgaggg gagacaagaa taaacgctca    2100

atgacgtcct tagaattgcg cattcctcac acaggatctt ttcgacagga ggctcacaac    2160

aggctccgga                                                           2170


<210> 3
<211> 1693
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-CD19-41-BB-CD3ζ Construct Plus Poly-A Tail and Sticky Bridge

<400> 3
gctagcgccg ccaccatgtt gctgctggtt acatctctgc tgctgtgcga gctgccccat      60

cctgcctttc tgctgatccc cgacatccag atgacccaga ccacaagcag cctgtctgcc     120

agcctgggcg atagagtgac catcagctgt agagccagcc aggacatcag caagtacctg     180

aactggtatc agcaaaagcc cgacggcacc gtgaagctgc tgatctacca caccagcaga     240

ctgcacagcg gcgtgccaag cagattttct ggcagcggct ctggcaccga ctacagcctg     300

accatctcca acctggaaca agaggatatc gctacctact tctgccagca aggcaacacc     360

ctgccttaca cctttggcgg aggcaccaag ctggaaatca ccggctctac aagcggcagc     420

ggcaaacctg gatctggcga gggatctacc aagggcgaag tgaaactgca agagtctggc     480

cctggactgg tggccccatc tcagtctctg agcgtgacct gtacagtcag cggagtgtcc     540

ctgcctgatt acggcgtgtc ctggatcaga cagcctcctc ggaaaggcct ggaatggctg     600

ggagtgatct ggggcagcga gacaacctac tacaacagcg ccctgaagtc ccggctgacc     660

atcatcaagg acaactccaa gagccaggtg ttcctgaaga tgaacagcct gcagaccgac     720

gacaccgcca tctactattg cgccaagcac tactactacg gcggcagcta cgccatggat     780

tattggggcc agggcaccag cgtgaccgtt tcttctgtgg ccgaccaaga attcgagcag     840

aagctgatct ccgaagagga cctgaccaca acacccgctc ctagacctcc aacaccagct     900

ccaacaatcg ccagccagcc tctgtctctc agacctgagg cttgtagacc tgctgctggc     960

ggagccgtgc atacaagagg actggatttc gcctgcgaca tctacatctg ggctcctctg    1020

gctggcacat gtggcgtgct gctgctgagc ctggtcatca ccctgtattg caagcggggc    1080

agaaagaaac tgctctacat cttcaagcag cccttcatgc ggcccgtgca gaccacacaa    1140

gaggaagatg gctgctcctg cagattcccc gaggaagaag aaggcggctg cgagctgaga    1200

gtgaagttca gcagatccgc cgacgctcct gcctatcagc agggccaaaa ccagctgtac    1260

aacgagctga acctggggag aagagaagag tacgacgtgc tggacaagcg gagaggcaga    1320

gatcctgaaa tgggcggcaa gcccagacgg aagaatcctc aagagggcct gtataatgag    1380

ctgcagaaag acaagatggc cgaggcctac agcgagatcg gaatgaaggg cgagcgcaga    1440

agaggcaagg gacacgatgg actgtaccag ggcctgagca ccgccaccaa ggatacctat    1500

gatgccctgc acatgcaggc cctgcctcca agatagaagc ttctcgagaa aaaaaaaaaa    1560

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaagt cgacctccta    1680

ggagctcggg ccc                                                       1693


<210> 4
<211> 65
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4 Aptamer Short Stick

<400> 4
gaggatcctc gagcccggtt ttttttgtga cgtcctgatc gattgtgcat tcggtgtgac     60

gatct                                                                 65


<210> 5
<211> 79
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD4 Aptamer Long Stick

<400> 5
ttttttttca gctggaggat cctcgagccc ggtttttttt gtgacgtcct gatcgattgt     60

gcattcggtg tgacgatct                                                  79


<210> 6
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD8 Aptamer Short Stick

<400> 6
gaggatcctc gagcccggtt ttttttctac agcttgctat gctccccttg gggta          55


<210> 7
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> CD8 Aptamer Long Stick

<400> 7
ttttttttca gctggaggat cctcgagccc ggtttttttt ctacagcttg ctatgctccc     60

cttggggta                                                             69


