                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS USEFUL FOR PROPHYLAXIS OF 
       ORGANOPHOSPHATES

<130>  UPN-16-7803PCT

<150>  US 62/323,781
<151>  2016-04-17

<150>  US 62/331,262
<151>  2016-05-03

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  602
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(26)
<223>  Innate leader/signal peptide/sequence

<220>
<221>  mat_peptide
<222>  (27)..(602)

<400>  1

Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
    -25                 -20                 -15                 


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
-10                 -5              -1  1               5       


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
            10                  15                  20          


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
        25                  30                  35              


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
    40                  45                  50                  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
55                  60                  65                  70  


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
                75                  80                  85      


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
            90                  95                  100         


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
        105                 110                 115             


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
    120                 125                 130                 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
135                 140                 145                 150 


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
                155                 160                 165     


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
            170                 175                 180         


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
        185                 190                 195             


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
    200                 205                 210                 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
215                 220                 225                 230 


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
                235                 240                 245     


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
            250                 255                 260         


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
        265                 270                 275             


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
    280                 285                 290                 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
295                 300                 305                 310 


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
                315                 320                 325     


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
            330                 335                 340         


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
        345                 350                 355             


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
    360                 365                 370                 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
375                 380                 385                 390 


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
                395                 400                 405     


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
            410                 415                 420         


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
        425                 430                 435             


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
    440                 445                 450                 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
455                 460                 465                 470 


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
                475                 480                 485     


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
            490                 495                 500         


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
        505                 510                 515             


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
    520                 525                 530                 


Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His 
535                 540                 545                 550 


Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr 
                555                 560                 565     


Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
            570                 575     


<210>  2
<211>  2416
<212>  DNA
<213>  Homo sapiens

<400>  2
tactgaatgt cagtgcagtc caatttacag gctggagcag cagctgcatc ctgcatttcc       60

ccgaagtatt acatgatttt cactccttgc aaactttacc atctttgttg cagagaatcg      120

gaaatcaata tgcatagcaa agtcacaatc atatgcatca gatttctctt ttggtttctt      180

ttgctctgca tgcttattgg gaagtcacat actgaagatg acatcataat tgcaacaaag      240

aatggaaaag tcagagggat gaacttgaca gtttttggtg gcacggtaac agcctttctt      300

ggaattccct atgcacagcc acctcttggt agacttcgat tcaaaaagcc acagtctctg      360

accaagtggt ctgatatttg gaatgccaca aaatatgcaa attcttgctg tcagaacata      420

gatcaaagtt ttccaggctt ccatggatca gagatgtgga acccaaacac tgacctcagt      480

gaagactgtt tatatctaaa tgtatggatt ccagcaccta aaccaaaaaa tgccactgta      540

ttgatatgga tttatggtgg tggttttcaa actggaacat catctttaca tgtttatgat      600

ggcaagtttc tggctcgggt tgaaagagtt attgtagtgt caatgaacta tagggtgggt      660

gccctaggat tcttagcttt gccaggaaat cctgaggctc cagggaacat gggtttattt      720

gatcaacagt tggctcttca gtgggttcaa aaaaatatag cagcctttgg tggaaatcct      780

aaaagtgtaa ctctctttgg agaaagtgca ggagcagctt cagttagcct gcatttgctt      840

tctcctggaa gccattcatt gttcaccaga gccattctgc aaagtggatc ctttaatgct      900

ccttgggcgg taacatctct ttatgaagct aggaacagaa cgttgaactt agctaaattg      960

actggttgct ctagagagaa tgagactgaa ataatcaagt gtcttagaaa taaagatccc     1020

caagaaattc ttctgaatga agcatttgtt gtcccctatg ggactccttt gtcagtaaac     1080

tttggtccga ccgtggatgg tgattttctc actgacatgc cagacatatt acttgaactt     1140

ggacaattta aaaaaaccca gattttggtg ggtgttaata aagatgaagg gacagctttt     1200

ttagtctatg gtgctcctgg cttcagcaaa gataacaata gtatcataac tagaaaagaa     1260

tttcaggaag gtttaaaaat attttttcca ggagtgagtg agtttggaaa ggaatccatc     1320

ctttttcatt acacagactg ggtagatgat cagagacctg aaaactaccg tgaggccttg     1380

ggtgatgttg ttggggatta taatttcata tgccctgcct tggagttcac caagaagttc     1440

tcagaatggg gaaataatgc ctttttctac tattttgaac accgatcctc caaacttccg     1500

tggccagaat ggatgggagt gatgcatggc tatgaaattg aatttgtctt tggtttacct     1560

ctggaaagaa gagataatta cacaaaagcc gaggaaattt tgagtagatc catagtgaaa     1620

cggtgggcaa attttgcaaa atatgggaat ccaaatgaga ctcagaacaa tagcacaagc     1680

tggcctgtct tcaaaagcac tgaacaaaaa tatctaacct tgaatacaga gtcaacaaga     1740

ataatgacga aactacgtgc tcaacaatgt cgattctgga catcattttt tccaaaagtc     1800

ttggaaatga caggaaatat tgatgaagca gaatgggagt ggaaagcagg attccatcgc     1860

tggaacaatt acatgatgga ctggaaaaat caatttaacg attacactag caagaaagaa     1920

agttgtgtgg gtctctaatt aatagattta ccctttatag aacatatttt cctttagatc     1980

aaggcaaaaa tatcaggagc ttttttacac acctactaaa aaagttatta tgtagctgaa     2040

acaaaaatgc cagaaggata atattgattc ctcacatctt taacttagta ttttacctag     2100

catttcaaaa cccaaatggc tagaacatgt ttaattaaat ttcacaatat aaagttctac     2160

agttaattat gtgcatatta aaacaatggc ctggttcaat ttctttcttt ccttaataaa     2220

tttaagtttt ttccccccaa aattatcagt gctctgcttt tagtcacgtg tattttcatt     2280

accactcgta aaaaggtatc ttttttaaat gaattaaata ttgaaacact gtacaccata     2340

gtttacaata ttatgtttcc taattaaaat aagaattgaa tgtcaatatg agatattaaa     2400

ataagcacag aaaatc                                                     2416


<210>  3
<211>  1832
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C0 with innate leader peptide.

<400>  3
tctagaccca ccatgcacag caaggtgacc atcatctgca tccggttcct gttctggttc       60

ctgctgctgt gcatgctgat cggaaagagc cacaccgagg atgatatcat catcgccacc      120

aagaacggaa aggtgcgggg aatgaacctg accgtgttcg gaggaaccgt gaccgccttc      180

ctgggaatcc catacgccca gccaccactg ggacggctgc ggttcaagaa gccacagagc      240

ctgaccaagt ggagcgatat ctggaacgcc accaagtacg ccaacagctg ctgccagaac      300

atcgatcaga gcttcccagg attccacgga agcgagatgt ggaacccaaa caccgatctg      360

agcgaggatt gcctgtacct gaacgtgtgg atcccagccc caaagccaaa gaacgccacc      420

gtgctgatct ggatctacgg aggaggattc cagaccggaa ccagcagcct gcacgtgtac      480

gatggaaagt tcctggcccg ggtggagcgg gtgatcgtgg tgagcatgaa ctaccgggtg      540

ggagccctgg gattcctggc cctgccagga aacccagagg ccccaggaaa catgggactg      600

ttcgatcagc agctggccct gcagtgggtg cagaagaaca tcgccgcctt cggaggaaac      660

ccaaagagcg tgaccctgtt cggagagagc gccggagccg ccagcgtgag cctgcacctg      720

ctgagcccag gaagccacag cctgttcacc cgggccatcc tgcagagcgg aagcttcaac      780

gccccatggg ccgtgaccag cctgtacgag gcccggaacc ggaccctgaa cctggccaag      840

ctgaccggat gcagccggga gaacgagacc gagatcatca agtgcctgcg gaacaaggat      900

ccacaggaga tcctgctgaa cgaggccttc gtggtgccat acggaacccc actgagcgtg      960

aacttcggac caaccgtgga tggagatttc ctgaccgata tgccagatat cctgctggag     1020

ctgggacagt tcaagaagac ccagatcctg gtgggagtga acaaggatga gggaaccgcc     1080

ttcctggtgt acggagcccc aggattcagc aaggataaca acagcatcat cacccggaag     1140

gagttccagg agggactgaa gatcttcttc ccaggagtga gcgagttcgg aaaggagagc     1200

atcctgttcc actacaccga ttgggtggat gatcagcggc cagagaacta ccgggaggcc     1260

ctgggagatg tggtgggaga ttacaacttc atctgcccag ccctggagtt caccaagaag     1320

ttcagcgagt ggggaaacaa cgccttcttc tactacttcg agcaccggag cagcaagctg     1380

ccatggccag agtggatggg agtgatgcac ggatacgaga tcgagttcgt gttcggactg     1440

ccactggagc ggcgggataa ctacaccaag gccgaggaga tcctgagccg gagcatcgtg     1500

aagcggtggg ccaacttcgc caagtacgga aacccaaacg agacccagaa caacagcacc     1560

agctggccag tgttcaagag caccgagcag aagtacctga ccctgaacac cgagagcacc     1620

cggatcatga ccaagctgcg ggcccagcag tgccggttct ggaccagctt cttcccaaag     1680

gtgctggaga tgaccggaaa catcgatgag gccgagtggg agtggaaggc cggattccac     1740

cggtggaaca actacatgat ggattggaag aaccagttca acgattacac cagcaagaag     1800

gagagctgcg tgggactgtg ataaggccgg cc                                   1832


<210>  4
<211>  1803
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C0 with IL2 leader peptide.

<400>  4
tctagaccca ccatgcggat gcagctgctg ctgctgatcg ccctgagcct ggccctggtg       60

accaacagcg aggatgatat catcatcgcc accaagaacg gaaaggtgcg gggaatgaac      120

ctgaccgtgt tcggaggaac cgtgaccgcc ttcctgggaa tcccatacgc ccagccacca      180

ctgggacggc tgcggttcaa gaagccacag agcctgacca agtggagcga tatctggaac      240

gccaccaagt acgccaacag ctgctgccag aacatcgatc agagcttccc aggattccac      300

ggaagcgaga tgtggaaccc aaacaccgat ctgagcgagg attgcctgta cctgaacgtg      360

tggatcccag ccccaaagcc aaagaacgcc accgtgctga tctggatcta cggaggagga      420

ttccagaccg gaaccagcag cctgcacgtg tacgatggaa agttcctggc ccgggtggag      480

cgggtgatcg tggtgagcat gaactaccgg gtgggagccc tgggattcct ggccctgcca      540

ggaaacccag aggccccagg aaacatggga ctgttcgatc agcagctggc cctgcagtgg      600

gtgcagaaga acatcgccgc cttcggagga aacccaaaga gcgtgaccct gttcggagag      660

agcgccggag ccgccagcgt gagcctgcac ctgctgagcc caggaagcca cagcctgttc      720

acccgggcca tcctgcagag cggaagcttc aacgccccat gggccgtgac cagcctgtac      780

gaggcccgga accggaccct gaacctggcc aagctgaccg gatgcagccg ggagaacgag      840

accgagatca tcaagtgcct gcggaacaag gatccacagg agatcctgct gaacgaggcc      900

ttcgtggtgc catacggaac cccactgagc gtgaacttcg gaccaaccgt ggatggagat      960

ttcctgaccg atatgccaga tatcctgctg gagctgggac agttcaagaa gacccagatc     1020

ctggtgggag tgaacaagga tgagggaacc gccttcctgg tgtacggagc cccaggattc     1080

agcaaggata acaacagcat catcacccgg aaggagttcc aggagggact gaagatcttc     1140

ttcccaggag tgagcgagtt cggaaaggag agcatcctgt tccactacac cgattgggtg     1200

gatgatcagc ggccagagaa ctaccgggag gccctgggag atgtggtggg agattacaac     1260

ttcatctgcc cagccctgga gttcaccaag aagttcagcg agtggggaaa caacgccttc     1320

ttctactact tcgagcaccg gagcagcaag ctgccatggc cagagtggat gggagtgatg     1380

cacggatacg agatcgagtt cgtgttcgga ctgccactgg agcggcggga taactacacc     1440

aaggccgagg agatcctgag ccggagcatc gtgaagcggt gggccaactt cgccaagtac     1500

ggaaacccaa acgagaccca gaacaacagc accagctggc cagtgttcaa gagcaccgag     1560

cagaagtacc tgaccctgaa caccgagagc acccggatca tgaccaagct gcgggcccag     1620

cagtgccggt tctggaccag cttcttccca aaggtgctgg agatgaccgg aaacatcgat     1680

gaggccgagt gggagtggaa ggccggattc caccggtgga acaactacat gatggattgg     1740

aagaaccagt tcaacgatta caccagcaag aaggagagct gcgtgggact gtgataaggc     1800

cgg                                                                   1803


<210>  5
<211>  1802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C1 with IL2 leader peptide.


<220>
<221>  sig_peptide
<222>  (11)..(67)
<223>  IL2

<400>  5
ctagacccac catgcggatg cagctgctgc tgctgattgc tctgagcctg gctctggtga       60

ccaacagcga agacgacatt attattgcta ccaagaacgg caaggtgcgg ggcatgaacc      120

tgaccgtgtt tggcggcacc gtgaccgctt ttctgggcat tccctatgct cagccccccc      180

tgggccggct gcggtttaag aagccccaga gcctgaccaa gtggagcgac atttggaacg      240

ctaccaagta tgctaacagc tgttgtcaga acattgacca gagctttccc ggctttcatg      300

gcagcgaaat gtggaacccc aacaccgacc tgagcgaaga ctgtctgtat ctgaacgtgt      360

ggattcccgc tcccaagccc aagaacgcta ccgtgctgat ttggatttat ggcggcggct      420

ttcagaccgg caccagcagc ctgcatgtgt atgacggcaa gtttctggct cgggtggaac      480

gggtgattgt ggtgagcatg aactatcggg tgggcgctct gggctttctg gctctgcccg      540

gcaaccccga agctcccggc aacatgggcc tgtttgacca gcagctggct ctgcagtggg      600

tgcagaagaa cattgctgct tttggcggca accccaagag cgtgaccctg tttggcgaaa      660

gcgctggcgc tgctagcgtg agcctgcatc tgctgagccc cggcagccat agcctgttta      720

cccgggctat tctgcagagc ggcagcttta acgctccctg ggctgtgacc agcctgtatg      780

aagctcggaa ccggaccctg aacctggcta agctgaccgg ctgtagccgg gaaaacgaaa      840

ccgaaattat taagtgtctg cggaacaagg acccccagga aattctgctg aacgaagctt      900

ttgtggtgcc ctatggcacc cccctgagcg tgaactttgg ccccaccgtg gacggcgact      960

ttctgaccga catgcccgac attctgctgg aactgggcca gtttaagaag acccagattc     1020

tggtgggcgt gaacaaggac gaaggcaccg cttttctggt gtatggcgct cccggcttta     1080

gcaaggacaa caacagcatt attacccgga aggaatttca ggaaggcctg aagatttttt     1140

ttcccggcgt gagcgaattt ggcaaggaaa gcattctgtt tcattatacc gactgggtgg     1200

acgaccagcg gcccgaaaac tatcgggaag ctctgggcga cgtggtgggc gactataact     1260

ttatttgtcc cgctctggaa tttaccaaga agtttagcga atggggcaac aacgcttttt     1320

tttattattt tgaacatcgg agcagcaagc tgccctggcc cgaatggatg ggcgtgatgc     1380

atggctatga aattgaattt gtgtttggcc tgcccctgga acggcgggac aactatacca     1440

aggctgaaga aattctgagc cggagcattg tgaagcggtg ggctaacttt gctaagtatg     1500

gcaaccccaa cgaaacccag aacaacagca ccagctggcc cgtgtttaag agcaccgaac     1560

agaagtatct gaccctgaac accgaaagca cccggattat gaccaagctg cgggctcagc     1620

agtgtcggtt ttggaccagc ttttttccca aggtgctgga aatgaccggc aacattgacg     1680

aagctgaatg ggaatggaag gctggctttc atcggtggaa caactatatg atggactgga     1740

agaaccagtt taacgactat accagcaaga aggaaagctg tgtgggcctg tgataaggcc     1800

gg                                                                    1802


<210>  6
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C2 with IL2 leader peptide.

<400>  6
tctagaccca ccatgagaat gcaattgttg ttgttgattg cattgtcatt ggcattggtg       60

acaaattcag aagatgatat tattattgca acaaaaaatg gtaaagtgag aggtatgaat      120

ttgacagtgt ttggtggtac agtgacagca tttttgggta ttccatatgc acaaccacca      180

ttgggtagat tgagatttaa aaaaccacaa tcattgacaa aatggtcaga tatttggaat      240

gcaacaaaat atgcaaattc atgttgtcaa aatattgatc aatcatttcc aggttttcat      300

ggttcagaaa tgtggaatcc aaatacagat ttgtcagaag attgtttgta tttgaatgtg      360

tggattccag caccaaaacc aaaaaatgca acagtgttga tttggattta tggtggtggt      420

tttcaaacag gtacatcatc attgcatgtg tatgatggta aatttttggc aagagtggaa      480

agagtgattg tggtgtcaat gaattataga gtgggtgcat tgggtttttt ggcattgcca      540

ggtaatccag aagcaccagg taatatgggt ttgtttgatc aacaattggc attgcaatgg      600

gtgcaaaaaa atattgcagc atttggtggt aatccaaaat cagtgacatt gtttggtgaa      660

tcagcaggtg cagcatcagt gtcattgcat ttgttgtcac caggttcaca ttcattgttt      720

acaagagcaa ttttgcaatc aggttcattt aatgcaccat gggcagtgac atcattgtat      780

gaagcaagaa atagaacatt gaatttggca aaattgacag gttgttcaag agaaaatgaa      840

acagaaatta ttaaatgttt gagaaataaa gatccacaag aaattttgtt gaatgaagca      900

tttgtggtgc catatggtac accattgtca gtgaattttg gtccaacagt ggatggtgat      960

tttttgacag atatgccaga tattttgttg gaattgggtc aatttaaaaa aacacaaatt     1020

ttggtgggtg tgaataaaga tgaaggtaca gcatttttgg tgtatggtgc accaggtttt     1080

tcaaaagata ataattcaat tattacaaga aaagaatttc aagaaggttt gaaaattttt     1140

tttccaggtg tgtcagaatt tggtaaagaa tcaattttgt ttcattatac agattgggtg     1200

gatgatcaaa gaccagaaaa ttatagagaa gcattgggtg atgtggtggg tgattataat     1260

tttatttgtc cagcattgga atttacaaaa aaattttcag aatggggtaa taatgcattt     1320

ttttattatt ttgaacatag atcatcaaaa ttgccatggc cagaatggat gggtgtgatg     1380

catggttatg aaattgaatt tgtgtttggt ttgccattgg aaagaagaga taattataca     1440

aaagcagaag aaattttgtc aagatcaatt gtgaaaagat gggcaaattt tgcaaaatat     1500

ggtaatccaa atgaaacaca aaataattca acatcatggc cagtgtttaa atcaacagaa     1560

caaaaatatt tgacattgaa tacagaatca acaagaatta tgacaaaatt gagagcacaa     1620

caatgtagat tttggacatc attttttcca aaagtgttgg aaatgacagg taatattgat     1680

gaagcagaat gggaatggaa agcaggtttt catagatgga ataattatat gatggattgg     1740

aaaaatcaat ttaatgatta tacatcaaaa aaagaatcat gtgtgggttt gtgataaggc     1800

cggcc                                                                 1805


<210>  7
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C3 with IL2 leader peptide.

<400>  7
tctagaccca ccatgagaat gcagcttctt cttcttatcg ctcttagcct tgctcttgtg       60

acaaacagcg aagatgatat catcatcgct acaaagaacg ggaaggtgag agggatgaac      120

cttacagtgt ttggggggac agtgacagct tttcttggga tcccttatgc tcagcctcct      180

cttgggagac ttagatttaa gaagcctcag agccttacaa agtggagcga tatctggaac      240

gctacaaagt atgctaacag ctgttgtcag aacatcgatc agagctttcc tgggtttcac      300

gggagcgaaa tgtggaaccc taacacagat cttagcgaag attgtcttta tcttaacgtg      360

tggatccctg ctcctaagcc taagaacgct acagtgctta tctggatcta tggggggggg      420

tttcagacag ggacaagcag ccttcacgtg tatgatggga agtttcttgc tagagtggaa      480

agagtgatcg tggtgagcat gaactataga gtgggggctc ttgggtttct tgctcttcct      540

gggaaccctg aagctcctgg gaacatgggg ctttttgatc agcagcttgc tcttcagtgg      600

gtgcagaaga acatcgctgc ttttgggggg aaccctaaga gcgtgacact ttttggggaa      660

agcgctgggg ctgctagcgt gagccttcac cttcttagcc ctgggagcca cagccttttt      720

acaagagcta tccttcagag cgggagcttt aacgctcctt gggctgtgac aagcctttat      780

gaagctagaa acagaacact taaccttgct aagcttacag ggtgtagcag agaaaacgaa      840

acagaaatca tcaagtgtct tagaaacaag gatcctcagg aaatccttct taacgaagct      900

tttgtggtgc cttatgggac acctcttagc gtgaactttg ggcctacagt ggatggggat      960

tttcttacag atatgcctga tatccttctt gaacttgggc agtttaagaa gacacagatc     1020

cttgtggggg tgaacaagga tgaagggaca gcttttcttg tgtatggggc tcctgggttt     1080

agcaaggata acaacagcat catcacaaga aaggaatttc aggaagggct taagatcttt     1140

tttcctgggg tgagcgaatt tgggaaggaa agcatccttt ttcactatac agattgggtg     1200

gatgatcaga gacctgaaaa ctatagagaa gctcttgggg atgtggtggg ggattataac     1260

tttatctgtc ctgctcttga atttacaaag aagtttagcg aatgggggaa caacgctttt     1320

ttttattatt ttgaacacag aagcagcaag cttccttggc ctgaatggat gggggtgatg     1380

cacgggtatg aaatcgaatt tgtgtttggg cttcctcttg aaagaagaga taactataca     1440

aaggctgaag aaatccttag cagaagcatc gtgaagagat gggctaactt tgctaagtat     1500

gggaacccta acgaaacaca gaacaacagc acaagctggc ctgtgtttaa gagcacagaa     1560

cagaagtatc ttacacttaa cacagaaagc acaagaatca tgacaaagct tagagctcag     1620

cagtgtagat tttggacaag cttttttcct aaggtgcttg aaatgacagg gaacatcgat     1680

gaagctgaat gggaatggaa ggctgggttt cacagatgga acaactatat gatggattgg     1740

aagaaccagt ttaacgatta tacaagcaag aaggaaagct gtgtggggct ttgataaggc     1800

cggcc                                                                 1805


<210>  8
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C4 with IL2 leader peptide.

<400>  8
tctagaccca ccatgagaat gcaacttctt cttcttattg cactttcact tgcacttgtt       60

acaaattcag aagatgatat tattattgca acaaaaaatg gaaaagttag aggaatgaat      120

cttacagttt tcggaggaac agttacagca ttccttggaa ttccatatgc acaaccacca      180

cttggaagac ttagattcaa aaaaccacaa tcacttacaa aatggtcaga tatttggaat      240

gcaacaaaat atgcaaattc atgttgtcaa aatattgatc aatcattccc aggattccat      300

ggatcagaaa tgtggaatcc aaatacagat ctttcagaag attgtcttta tcttaatgtt      360

tggattccag caccaaaacc aaaaaatgca acagttctta tttggattta tggaggagga      420

ttccaaacag gaacatcatc acttcatgtt tatgatggaa aattccttgc aagagttgaa      480

agagttattg ttgtttcaat gaattataga gttggagcac ttggattcct tgcacttcca      540

ggaaatccag aagcaccagg aaatatggga cttttcgatc aacaacttgc acttcaatgg      600

gttcaaaaaa atattgcagc attcggagga aatccaaaat cagttacact tttcggagaa      660

tcagcaggag cagcatcagt ttcacttcat cttctttcac caggatcaca ttcacttttc      720

acaagagcaa ttcttcaatc aggatcattc aatgcaccat gggcagttac atcactttat      780

gaagcaagaa atagaacact taatcttgca aaacttacag gatgttcaag agaaaatgaa      840

acagaaatta ttaaatgtct tagaaataaa gatccacaag aaattcttct taatgaagca      900

ttcgttgttc catatggaac accactttca gttaatttcg gaccaacagt tgatggagat      960

ttccttacag atatgccaga tattcttctt gaacttggac aattcaaaaa aacacaaatt     1020

cttgttggag ttaataaaga tgaaggaaca gcattccttg tttatggagc accaggattc     1080

tcaaaagata ataattcaat tattacaaga aaagaattcc aagaaggact taaaattttc     1140

ttcccaggag tttcagaatt cggaaaagaa tcaattcttt tccattatac agattgggtt     1200

gatgatcaaa gaccagaaaa ttatagagaa gcacttggag atgttgttgg agattataat     1260

ttcatttgtc cagcacttga attcacaaaa aaattctcag aatggggaaa taatgcattc     1320

ttctattatt tcgaacatag atcatcaaaa cttccatggc cagaatggat gggagttatg     1380

catggatatg aaattgaatt cgttttcgga cttccacttg aaagaagaga taattataca     1440

aaagcagaag aaattctttc aagatcaatt gttaaaagat gggcaaattt cgcaaaatat     1500

ggaaatccaa atgaaacaca aaataattca acatcatggc cagttttcaa atcaacagaa     1560

caaaaatatc ttacacttaa tacagaatca acaagaatta tgacaaaact tagagcacaa     1620

caatgtagat tctggacatc attcttccca aaagttcttg aaatgacagg aaatattgat     1680

gaagcagaat gggaatggaa agcaggattc catagatgga ataattatat gatggattgg     1740

aaaaatcaat tcaatgatta tacatcaaaa aaagaatcat gtgttggact ttgataaggc     1800

cggcc                                                                 1805


<210>  9
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C5 with IL2 leader peptide.

<400>  9
tctagaccca ccatgcgtat gcagctgctg ctgctgattg cgctgagcct ggcgctggtg       60

accaacagcg aagatgatat tattattgcg accaaaaacg gcaaagtgcg tggcatgaac      120

ctgaccgtgt ttggcggcac cgtgaccgcg tttctgggca ttccgtatgc gcagccgccg      180

ctgggccgtc tgcgttttaa aaaaccgcag agcctgacca aatggagcga tatttggaac      240

gcgaccaaat atgcgaacag ctgctgccag aacattgatc agagctttcc gggctttcat      300

ggcagcgaaa tgtggaaccc gaacaccgat ctgagcgaag attgcctgta tctgaacgtg      360

tggattccgg cgccgaaacc gaaaaacgcg accgtgctga tttggattta tggcggcggc      420

tttcagaccg gcaccagcag cctgcatgtg tatgatggca aatttctggc gcgtgtggaa      480

cgtgtgattg tggtgagcat gaactatcgt gtgggcgcgc tgggctttct ggcgctgccg      540

ggcaacccgg aagcgccggg caacatgggc ctgtttgatc agcagctggc gctgcagtgg      600

gtgcagaaaa acattgcggc gtttggcggc aacccgaaaa gcgtgaccct gtttggcgaa      660

agcgcgggcg cggcgagcgt gagcctgcat ctgctgagcc cgggcagcca tagcctgttt      720

acccgtgcga ttctgcagag cggcagcttt aacgcgccgt gggcggtgac cagcctgtat      780

gaagcgcgta accgtaccct gaacctggcg aaactgaccg gctgcagccg tgaaaacgaa      840

accgaaatta ttaaatgcct gcgtaacaaa gatccgcagg aaattctgct gaacgaagcg      900

tttgtggtgc cgtatggcac cccgctgagc gtgaactttg gcccgaccgt ggatggcgat      960

tttctgaccg atatgccgga tattctgctg gaactgggcc agtttaaaaa aacccagatt     1020

ctggtgggcg tgaacaaaga tgaaggcacc gcgtttctgg tgtatggcgc gccgggcttt     1080

agcaaagata acaacagcat tattacccgt aaagaatttc aggaaggcct gaaaattttt     1140

tttccgggcg tgagcgaatt tggcaaagaa agcattctgt ttcattatac cgattgggtg     1200

gatgatcagc gtccggaaaa ctatcgtgaa gcgctgggcg atgtggtggg cgattataac     1260

tttatttgcc cggcgctgga atttaccaaa aaatttagcg aatggggcaa caacgcgttt     1320

ttttattatt ttgaacatcg tagcagcaaa ctgccgtggc cggaatggat gggcgtgatg     1380

catggctatg aaattgaatt tgtgtttggc ctgccgctgg aacgtcgtga taactatacc     1440

aaagcggaag aaattctgag ccgtagcatt gtgaaacgtt gggcgaactt tgcgaaatat     1500

ggcaacccga acgaaaccca gaacaacagc accagctggc cggtgtttaa aagcaccgaa     1560

cagaaatatc tgaccctgaa caccgaaagc acccgtatta tgaccaaact gcgtgcgcag     1620

cagtgccgtt tttggaccag cttttttccg aaagtgctgg aaatgaccgg caacattgat     1680

gaagcggaat gggaatggaa agcgggcttt catcgttgga acaactatat gatggattgg     1740

aaaaaccagt ttaacgatta taccagcaaa aaagaaagct gcgtgggcct gtgataaggc     1800

cggcc                                                                 1805


<210>  10
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C6 with IL2 leader peptide.

<400>  10
tctagaccca ccatgcgaat gcagctgctg ctgctgatcg cactgagcct ggcactggtg       60

accaacagcg aggacgacat catcatcgca accaagaacg gaaaggtgcg aggaatgaac      120

ctgaccgtgt tcggaggaac cgtgaccgca ttcctgggaa tcccatacgc acagccacca      180

ctgggacgac tgcgattcaa gaagccacag agcctgacca agtggagcga catctggaac      240

gcaaccaagt acgcaaacag ctgttgtcag aacatcgacc agagcttccc aggattccat      300

ggaagcgaga tgtggaaccc aaacaccgac ctgagcgagg actgtctgta cctgaacgtg      360

tggatcccag caccaaagcc aaagaacgca accgtgctga tctggatcta cggaggagga      420

ttccagaccg gaaccagcag cctgcatgtg tacgacggaa agttcctggc acgagtggag      480

cgagtgatcg tggtgagcat gaactaccga gtgggagcac tgggattcct ggcactgcca      540

ggaaacccag aggcaccagg aaacatggga ctgttcgacc agcagctggc actgcagtgg      600

gtgcagaaga acatcgcagc attcggagga aacccaaaga gcgtgaccct gttcggagag      660

agcgcaggag cagcaagcgt gagcctgcat ctgctgagcc caggaagcca tagcctgttc      720

acccgagcaa tcctgcagag cggaagcttc aacgcaccat gggcagtgac cagcctgtac      780

gaggcacgaa accgaaccct gaacctggca aagctgaccg gatgtagccg agagaacgag      840

accgagatca tcaagtgtct gcgaaacaag gacccacagg agatcctgct gaacgaggca      900

ttcgtggtgc catacggaac cccactgagc gtgaacttcg gaccaaccgt ggacggagac      960

ttcctgaccg acatgccaga catcctgctg gagctgggac agttcaagaa gacccagatc     1020

ctggtgggag tgaacaagga cgagggaacc gcattcctgg tgtacggagc accaggattc     1080

agcaaggaca acaacagcat catcacccga aaggagttcc aggagggact gaagatcttc     1140

ttcccaggag tgagcgagtt cggaaaggag agcatcctgt tccattacac cgactgggtg     1200

gacgaccagc gaccagagaa ctaccgagag gcactgggag acgtggtggg agactacaac     1260

ttcatctgtc cagcactgga gttcaccaag aagttcagcg agtggggaaa caacgcattc     1320

ttctactact tcgagcatcg aagcagcaag ctgccatggc cagagtggat gggagtgatg     1380

catggatacg agatcgagtt cgtgttcgga ctgccactgg agcgacgaga caactacacc     1440

aaggcagagg agatcctgag ccgaagcatc gtgaagcgat gggcaaactt cgcaaagtac     1500

ggaaacccaa acgagaccca gaacaacagc accagctggc cagtgttcaa gagcaccgag     1560

cagaagtacc tgaccctgaa caccgagagc acccgaatca tgaccaagct gcgagcacag     1620

cagtgtcgat tctggaccag cttcttccca aaggtgctgg agatgaccgg aaacatcgac     1680

gaggcagagt gggagtggaa ggcaggattc catcgatgga acaactacat gatggactgg     1740

aagaaccagt tcaacgacta caccagcaag aaggagagct gtgtgggact gtgataaggc     1800

cggcc                                                                 1805


<210>  11
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C7 with IL2 leader peptide.

<400>  11
tctagaccca ccatgagaat gcaattatta ttattaattg cattatcatt agcattagtt       60

acaaattcag aagatgatat tattattgca acaaaaaatg gtaaagttag aggtatgaat      120

ttaacagttt ttggtggtac agttacagca tttttaggta ttccatatgc acaaccacca      180

ttaggtagat taagatttaa aaaaccacaa tcattaacaa aatggtcaga tatttggaat      240

gcaacaaaat atgcaaattc atgttgtcaa aatattgatc aatcatttcc aggttttcat      300

ggttcagaaa tgtggaatcc aaatacagat ttatcagaag attgtttata tttaaatgtt      360

tggattccag caccaaaacc aaaaaatgca acagttttaa tttggattta tggtggtggt      420

tttcaaacag gtacatcatc attacatgtt tatgatggta aatttttagc aagagttgaa      480

agagttattg ttgtttcaat gaattataga gttggtgcat taggtttttt agcattacca      540

ggtaatccag aagcaccagg taatatgggt ttatttgatc aacaattagc attacaatgg      600

gttcaaaaaa atattgcagc atttggtggt aatccaaaat cagttacatt atttggtgaa      660

tcagcaggtg cagcatcagt ttcattacat ttattatcac caggttcaca ttcattattt      720

acaagagcaa ttttacaatc aggttcattt aatgcaccat gggcagttac atcattatat      780

gaagcaagaa atagaacatt aaatttagca aaattaacag gttgttcaag agaaaatgaa      840

acagaaatta ttaaatgttt aagaaataaa gatccacaag aaattttatt aaatgaagca      900

tttgttgttc catatggtac accattatca gttaattttg gtccaacagt tgatggtgat      960

tttttaacag atatgccaga tattttatta gaattaggtc aatttaaaaa aacacaaatt     1020

ttagttggtg ttaataaaga tgaaggtaca gcatttttag tttatggtgc accaggtttt     1080

tcaaaagata ataattcaat tattacaaga aaagaatttc aagaaggttt aaaaattttt     1140

tttccaggtg tttcagaatt tggtaaagaa tcaattttat ttcattatac agattgggtt     1200

gatgatcaaa gaccagaaaa ttatagagaa gcattaggtg atgttgttgg tgattataat     1260

tttatttgtc cagcattaga atttacaaaa aaattttcag aatggggtaa taatgcattt     1320

ttttattatt ttgaacatag atcatcaaaa ttaccatggc cagaatggat gggtgttatg     1380

catggttatg aaattgaatt tgtttttggt ttaccattag aaagaagaga taattataca     1440

aaagcagaag aaattttatc aagatcaatt gttaaaagat gggcaaattt tgcaaaatat     1500

ggtaatccaa atgaaacaca aaataattca acatcatggc cagtttttaa atcaacagaa     1560

caaaaatatt taacattaaa tacagaatca acaagaatta tgacaaaatt aagagcacaa     1620

caatgtagat tttggacatc attttttcca aaagttttag aaatgacagg taatattgat     1680

gaagcagaat gggaatggaa agcaggtttt catagatgga ataattatat gatggattgg     1740

aaaaatcaat ttaatgatta tacatcaaaa aaagaatcat gtgttggttt atgataaggc     1800

cggcc                                                                 1805


<210>  12
<211>  1802
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE C8 with IL2 leader peptide.

<400>  12
ctagacccac catgagaatg cagctgctgc tgctgatcgc tctgtcactg gctctggtga       60

ccaactcaga ggatgatatc atcatcgcta ccaaaaacgg aaaagtgaga ggaatgaacc      120

tgaccgtgtt cggaggaacc gtgaccgctt tcctgggaat cccctatgct cagccccccc      180

tgggaagact gagattcaaa aaaccccagt cactgaccaa atggtcagat atctggaacg      240

ctaccaaata tgctaactca tgctgccaga acatcgatca gtcattcccc ggattccatg      300

gatcagagat gtggaacccc aacaccgatc tgtcagagga ttgcctgtat ctgaacgtgt      360

ggatccccgc tcccaaaccc aaaaacgcta ccgtgctgat ctggatctat ggaggaggat      420

tccagaccgg aacctcatca ctgcatgtgt atgatggaaa attcctggct agagtggaga      480

gagtgatcgt ggtgtcaatg aactatagag tgggagctct gggattcctg gctctgcccg      540

gaaaccccga ggctcccgga aacatgggac tgttcgatca gcagctggct ctgcagtggg      600

tgcagaaaaa catcgctgct ttcggaggaa accccaaatc agtgaccctg ttcggagagt      660

cagctggagc tgcttcagtg tcactgcatc tgctgtcacc cggatcacat tcactgttca      720

ccagagctat cctgcagtca ggatcattca acgctccctg ggctgtgacc tcactgtatg      780

aggctagaaa cagaaccctg aacctggcta aactgaccgg atgctcaaga gagaacgaga      840

ccgagatcat caaatgcctg agaaacaaag atccccagga gatcctgctg aacgaggctt      900

tcgtggtgcc ctatggaacc cccctgtcag tgaacttcgg acccaccgtg gatggagatt      960

tcctgaccga tatgcccgat atcctgctgg agctgggaca gttcaaaaaa acccagatcc     1020

tggtgggagt gaacaaagat gagggaaccg ctttcctggt gtatggagct cccggattct     1080

caaaagataa caactcaatc atcaccagaa aagagttcca ggagggactg aaaatcttct     1140

tccccggagt gtcagagttc ggaaaagagt caatcctgtt ccattatacc gattgggtgg     1200

atgatcagag acccgagaac tatagagagg ctctgggaga tgtggtggga gattataact     1260

tcatctgccc cgctctggag ttcaccaaaa aattctcaga gtggggaaac aacgctttct     1320

tctattattt cgagcataga tcatcaaaac tgccctggcc cgagtggatg ggagtgatgc     1380

atggatatga gatcgagttc gtgttcggac tgcccctgga gagaagagat aactatacca     1440

aagctgagga gatcctgtca agatcaatcg tgaaaagatg ggctaacttc gctaaatatg     1500

gaaaccccaa cgagacccag aacaactcaa cctcatggcc cgtgttcaaa tcaaccgagc     1560

agaaatatct gaccctgaac accgagtcaa ccagaatcat gaccaaactg agagctcagc     1620

agtgcagatt ctggacctca ttcttcccca aagtgctgga gatgaccgga aacatcgatg     1680

aggctgagtg ggagtggaaa gctggattcc atagatggaa caactatatg atggattgga     1740

aaaaccagtt caacgattat acctcaaaaa aagagtcatg cgtgggactg tgataaggcc     1800

gg                                                                    1802


<210>  13
<211>  1805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human BChE mutated at G117H and E197Q with IL2 leader peptide.

<400>  13
tctagaccca ccatgcggat gcagctgctg ctgctgatcg ccctgagcct ggccctggtg       60

accaacagcg aggatgatat catcatcgcc accaagaacg gaaaggtgcg gggaatgaac      120

ctgaccgtgt tcggaggaac cgtgaccgcc ttcctgggaa tcccatacgc ccagccacca      180

ctgggacggc tgcggttcaa gaagccacag agcctgacca agtggagcga tatctggaac      240

gccaccaagt acgccaacag ctgctgccag aacatcgatc agagcttccc aggattccac      300

ggaagcgaga tgtggaaccc aaacaccgat ctgagcgagg attgcctgta cctgaacgtg      360

tggatcccag ccccaaagcc aaagaacgcc accgtgctga tctggatcta cggaggacac      420

ttccagaccg gaaccagcag cctgcacgtg tacgatggaa agttcctggc ccgggtggag      480

cgggtgatcg tggtgagcat gaactaccgg gtgggagccc tgggattcct ggccctgcca      540

ggaaacccag aggccccagg aaacatggga ctgttcgatc agcagctggc cctgcagtgg      600

gtgcagaaga acatcgccgc cttcggagga aacccaaaga gcgtgaccct gttcggacag      660

agcgccggag ccgccagcgt gagcctgcac ctgctgagcc caggaagcca cagcctgttc      720

acccgggcca tcctgcagag cggaagcttc aacgccccat gggccgtgac cagcctgtac      780

gaggcccgga accggaccct gaacctggcc aagctgaccg gatgcagccg ggagaacgag      840

accgagatca tcaagtgcct gcggaacaag gatccacagg agatcctgct gaacgaggcc      900

ttcgtggtgc catacggaac cccactgagc gtgaacttcg gaccaaccgt ggatggagat      960

ttcctgaccg atatgccaga tatcctgctg gagctgggac agttcaagaa gacccagatc     1020

ctggtgggag tgaacaagga tgagggaacc gccttcctgg tgtacggagc cccaggattc     1080

agcaaggata acaacagcat catcacccgg aaggagttcc aggagggact gaagatcttc     1140

ttcccaggag tgagcgagtt cggaaaggag agcatcctgt tccactacac cgattgggtg     1200

gatgatcagc ggccagagaa ctaccgggag gccctgggag atgtggtggg agattacaac     1260

ttcatctgcc cagccctgga gttcaccaag aagttcagcg agtggggaaa caacgccttc     1320

ttctactact tcgagcaccg gagcagcaag ctgccatggc cagagtggat gggagtgatg     1380

cacggatacg agatcgagtt cgtgttcgga ctgccactgg agcggcggga taactacacc     1440

aaggccgagg agatcctgag ccggagcatc gtgaagcggt gggccaactt cgccaagtac     1500

ggaaacccaa acgagaccca gaacaacagc accagctggc cagtgttcaa gagcaccgag     1560

cagaagtacc tgaccctgaa caccgagagc acccggatca tgaccaagct gcgggcccag     1620

cagtgccggt tctggaccag cttcttccca aaggtgctgg agatgaccgg aaacatcgat     1680

gaggccgagt gggagtggaa ggccggattc caccggtgga acaactacat gatggattgg     1740

aagaaccagt tcaacgatta caccagcaag aaggagagct gcgtgggact gtgataaggc     1800

cggcc                                                                 1805


<210>  14
<211>  742
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV promoter

<400>  14
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc      720

tcgtttagtg aaccgtcaga tc                                               742


<210>  15
<211>  382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV IE promoter

<400>  15
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt ac                                               382


<210>  16
<211>  281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB promoter

<400>  16
tggtcgaggt gagccccacg ttctgcttca ctctccccat ctcccccccc tccccacccc       60

caattttgta tttatttatt ttttaattat tttgtgcagc gatgggggcg gggggggggg      120

gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg gggcggggcg aggcggagag      180

gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt tccttttatg gcgaggcggc      240

ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc g                          281


<210>  17
<211>  260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4 enhancer

<400>  17
gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat       60

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      120

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      180

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      240

acatgacctt atgggacttt                                                  260


<210>  18
<211>  1227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UbC pormoter

<400>  18
ggcctccgcg ccgggttttg gcgcctcccg cgggcgcccc cctcctcacg gcgagcgctg       60

ccacgtcaga cgaagggcgc aggagcgtcc tgatccttcc gcccggacgc tcaggacagc      120

ggcccgctgc tcataagact cggccttaga accccagtat cagcagaagg acattttagg      180

acgggacttg ggtgactcta gggcactggt tttctttcca gagagcggaa caggcgagga      240

aaagtagtcc cttctcggcg attctgcgga gggatctccg tggggcggtg aacgccgatg      300

attatataag gacgcgccgg gtgtggcaca gctagttccg tcgcagccgg gatttgggtc      360

gcggttcttg tttgtggatc gctgtgatcg tcacttggtg agtagcgggc tgctgggctg      420

gccggggctt tcgtggccgc cgggccgctc ggtgggacgg aagcgtgtgg agagaccgcc      480

aagggctgta gtctgggtcc gcgagcaagg ttgccctgaa ctgggggttg gggggagcgc      540

agcaaaatgg cggctgttcc cgagtcttga atggaagacg cttgtgaggc gggctgtgag      600

gtcgttgaaa caaggtgggg ggcatggtgg gcggcaagaa cccaaggtct tgaggccttc      660

gctaatgcgg gaaagctctt attcgggtga gatgggctgg ggcaccatct ggggaccctg      720

acgtgaagtt tgtcactgac tggagaactc ggtttgtcgt ctgttgcggg ggcggcagtt      780

atgcggtgcc gttgggcagt gcacccgtac ctttgggagc gcgcgccctc gtcgtgtcgt      840

gacgtcaccc gttctgttgg cttataatgc agggtggggc cacctgccgg taggtgtgcg      900

gtaggctttt ctccgtcgca ggacgcaggg ttcgggccta gggtaggctc tcctgaatcg      960

acaggcgccg gacctctggt gaggggaggg ataagtgagg cgtcagtttc tttggtcggt     1020

tttatgtacc tatcttctta agtagctgaa gctccggttt tgaactatgc gctcggggtt     1080

ggcgagtgtg ttttgtgaag ttttttaggc accttttgaa atgtaatcat ttgggtcaat     1140

atgtaatttt cagtgttaga ctagtaaatt gtccgctaaa ttctggccgt ttttggcttt     1200

tttgttagac gaagctttat tgcggta                                         1227


<210>  19
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  c-myc

<400>  19
gcggggactt tgcactggaa cttacaacac ccgagcaagg acgcgactct a                51


<210>  20
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL2 leader sequence

<400>  20
atgcggatgc agctgctgct gctgattgct ctgagcctgg ctctggtgac caacagc          57


<210>  21
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mutated IL2 leader sequence

<400>  21
atgcggatgc agctgctgct gctgatcgcc ctgagcctgg ccctggtgac caacagc          57


<210>  22
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IRES

<400>  22
gcccctctcc ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt       60

gtgcgtttgt ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc      120

ggaaacctgg ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag      180

gaatgcaagg tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac      240

aaacaacgtc tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc      300

tctgcggcca aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc      360

acgttgtgag ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca      420

aggggctgaa ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt      480

acacatgctt tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg      540

gggacgtggt tttcctttga aaaacacgat gataatatgg ccacaaccat g               591


<210>  23
<211>  226
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PRIMA1 PRP

<400>  23
gcatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacaaac agtccacaga       60

agagctgcag caaggtgacc gatagctgcc ggcacgtgtg ccagtgccgg ccaccaccac      120

cactgccacc accaccacca cggctgctga gcgccccagc cccaaacagc accagctgcc      180

caaccgagga gagctggtgg agcggatgat gaaagcttgc ggccgc                     226


<210>  24
<211>  280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lamelledipodin (LDPN) PRP

<400>  24
gcatgcaact cctgtcttgc attgcactaa gtcttgcact tgtcacaaac agtccacagc       60

caaagatcgt gaccccatac accgccagcc agccaagccc accactgcca ccaccaccac      120

caccaccacc accaccacca ccaccaccac caccaccacc accaccactg ccaagccaga      180

gcgccccaag cgccggaagc gccgccccaa tgttcgtgaa gtacagcacc atcacccggc      240

tgcagaacgc cagccagcac agcggaaagc ttgcggccgc                            280


<210>  25
<211>  595
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WPRE

<400>  25
cgataatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt       60

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc      120

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga      180

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc      240

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct      300

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg      360

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct      420

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc      480

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg      540

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcat           595


<210>  26
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rabbit beta-globin (rBG) polyA

<400>  26
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  27
<211>  232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SV40 polyA

<400>  27
cgagcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga       60

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc      120

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag      180

atgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtaaaat cg              232


<210>  28
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 5'ITR

<400>  28
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  29
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV2 3'ITR

<400>  29
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgcag                                                             130


<210>  30
<211>  4835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UbC-cmyc-IL2-BChE C1-IRES-IL2-PRIMA1-SV40


<220>
<221>  repeat_region
<222>  (14)..(143)
<223>  5'ITR

<220>
<221>  promoter
<222>  (204)..(1430)
<223>  UbC promoter

<220>
<221>  Intron
<222>  (1524)..(1656)
<223>  Promega chimeric intron (PI)

<220>
<221>  misc_feature
<222>  (1771)..(3572)
<223>  BChE coding sequence C1

<220>
<221>  misc_feature
<222>  (1782)..(1838)
<223>  human IL2 leader sequence

<220>
<221>  misc_feature
<222>  (3572)..(4162)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4167)..(4407)
<223>  PRIMA1 PRP

<220>
<221>  polyA
<222>  (4410)..(4641)
<223>  SV40 late PolyA

<220>
<221>  repeat_region
<222>  (4706)..(4835)
<223>  3'ITR

<400>  30
ggccttaatt aggctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg       60

tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac      180

gtagccatgc tctaggaaga tctggcctcc gcgccgggtt ttggcgcctc ccgcgggcgc      240

ccccctcctc acggcgagcg ctgccacgtc agacgaaggg cgcaggagcg tcctgatcct      300

tccgcccgga cgctcaggac agcggcccgc tgctcataag actcggcctt agaaccccag      360

tatcagcaga aggacatttt aggacgggac ttgggtgact ctagggcact ggttttcttt      420

ccagagagcg gaacaggcga ggaaaagtag tcccttctcg gcgattctgc ggagggatct      480

ccgtggggcg gtgaacgccg atgattatat aaggacgcgc cgggtgtggc acagctagtt      540

ccgtcgcagc cgggatttgg gtcgcggttc ttgtttgtgg atcgctgtga tcgtcacttg      600

gtgagtagcg ggctgctggg ctggccgggg ctttcgtggc cgccgggccg ctcggtggga      660

cggaagcgtg tggagagacc gccaagggct gtagtctggg tccgcgagca aggttgccct      720

gaactggggg ttggggggag cgcagcaaaa tggcggctgt tcccgagtct tgaatggaag      780

acgcttgtga ggcgggctgt gaggtcgttg aaacaaggtg gggggcatgg tgggcggcaa      840

gaacccaagg tcttgaggcc ttcgctaatg cgggaaagct cttattcggg tgagatgggc      900

tggggcacca tctggggacc ctgacgtgaa gtttgtcact gactggagaa ctcggtttgt      960

cgtctgttgc gggggcggca gttatgcggt gccgttgggc agtgcacccg tacctttggg     1020

agcgcgcgcc ctcgtcgtgt cgtgacgtca cccgttctgt tggcttataa tgcagggtgg     1080

ggccacctgc cggtaggtgt gcggtaggct tttctccgtc gcaggacgca gggttcgggc     1140

ctagggtagg ctctcctgaa tcgacaggcg ccggacctct ggtgagggga gggataagtg     1200

aggcgtcagt ttctttggtc ggttttatgt acctatcttc ttaagtagct gaagctccgg     1260

ttttgaacta tgcgctcggg gttggcgagt gtgttttgtg aagtttttta ggcacctttt     1320

gaaatgtaat catttgggtc aatatgtaat tttcagtgtt agactagtaa attgtccgct     1380

aaattctggc cgtttttggc ttttttgtta gacgaagctt tattgcggta gtttatcaca     1440

gttaaattgc taacgcagtc agtgcttctg acacaacagt ctcgaactta agctgcagaa     1500

gttggtcgtg aggcactggg caggtaagta tcaaggttac aagacaggtt taaggagacc     1560

aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag gcacctattg     1620

gtcttactga catccacttt gcctttctct ccacaggtgt ccactcccag ttcaattaca     1680

gctcttaagg ctagagtact taatacgact cactataggc tagcggggac tttgcactgg     1740

aacttacaac acccgagcaa ggacgcgact ctagacccac catgcggatg cagctgctgc     1800

tgctgattgc tctgagcctg gctctggtga ccaacagcga agacgacatt attattgcta     1860

ccaagaacgg caaggtgcgg ggcatgaacc tgaccgtgtt tggcggcacc gtgaccgctt     1920

ttctgggcat tccctatgct cagccccccc tgggccggct gcggtttaag aagccccaga     1980

gcctgaccaa gtggagcgac atttggaacg ctaccaagta tgctaacagc tgttgtcaga     2040

acattgacca gagctttccc ggctttcatg gcagcgaaat gtggaacccc aacaccgacc     2100

tgagcgaaga ctgtctgtat ctgaacgtgt ggattcccgc tcccaagccc aagaacgcta     2160

ccgtgctgat ttggatttat ggcggcggct ttcagaccgg caccagcagc ctgcatgtgt     2220

atgacggcaa gtttctggct cgggtggaac gggtgattgt ggtgagcatg aactatcggg     2280

tgggcgctct gggctttctg gctctgcccg gcaaccccga agctcccggc aacatgggcc     2340

tgtttgacca gcagctggct ctgcagtggg tgcagaagaa cattgctgct tttggcggca     2400

accccaagag cgtgaccctg tttggcgaaa gcgctggcgc tgctagcgtg agcctgcatc     2460

tgctgagccc cggcagccat agcctgttta cccgggctat tctgcagagc ggcagcttta     2520

acgctccctg ggctgtgacc agcctgtatg aagctcggaa ccggaccctg aacctggcta     2580

agctgaccgg ctgtagccgg gaaaacgaaa ccgaaattat taagtgtctg cggaacaagg     2640

acccccagga aattctgctg aacgaagctt ttgtggtgcc ctatggcacc cccctgagcg     2700

tgaactttgg ccccaccgtg gacggcgact ttctgaccga catgcccgac attctgctgg     2760

aactgggcca gtttaagaag acccagattc tggtgggcgt gaacaaggac gaaggcaccg     2820

cttttctggt gtatggcgct cccggcttta gcaaggacaa caacagcatt attacccgga     2880

aggaatttca ggaaggcctg aagatttttt ttcccggcgt gagcgaattt ggcaaggaaa     2940

gcattctgtt tcattatacc gactgggtgg acgaccagcg gcccgaaaac tatcgggaag     3000

ctctgggcga cgtggtgggc gactataact ttatttgtcc cgctctggaa tttaccaaga     3060

agtttagcga atggggcaac aacgcttttt tttattattt tgaacatcgg agcagcaagc     3120

tgccctggcc cgaatggatg ggcgtgatgc atggctatga aattgaattt gtgtttggcc     3180

tgcccctgga acggcgggac aactatacca aggctgaaga aattctgagc cggagcattg     3240

tgaagcggtg ggctaacttt gctaagtatg gcaaccccaa cgaaacccag aacaacagca     3300

ccagctggcc cgtgtttaag agcaccgaac agaagtatct gaccctgaac accgaaagca     3360

cccggattat gaccaagctg cgggctcagc agtgtcggtt ttggaccagc ttttttccca     3420

aggtgctgga aatgaccggc aacattgacg aagctgaatg ggaatggaag gctggctttc     3480

atcggtggaa caactatatg atggactgga agaaccagtt taacgactat accagcaaga     3540

aggaaagctg tgtgggcctg tgataaggcc ggcccctctc cctccccccc ccctaacgtt     3600

actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc     3660

atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc     3720

attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag     3780

gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg     3840

cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat     3900

acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga     3960

gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc     4020

cattgtatgg gatctgatct ggggcctcgg tacacatgct ttacatgtgt ttagtcgagg     4080

ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga     4140

tgataatatg gccacaacca tgtaccgcat gcaactcctg tcttgcattg cactaagtct     4200

tgcacttgtc acaaacagtc cacagaagag ctgcagcaag gtgaccgata gctgccggca     4260

cgtgtgccag tgccggccac caccaccact gccaccacca ccaccaccac caccaccacc     4320

acggctgctg agcgccccag ccccaaacag caccagctgc ccaaccgagg agagctggtg     4380

gagcggatga tgaaagcttg cggccgcttc gagcagacat gataagatac attgatgagt     4440

ttggacaaac cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg     4500

ctattgcttt atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca     4560

ttcattttat gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc     4620

tctacaaatg tggtaaaatc gataaggatc ttcctagagc atggctacgt agataagtag     4680

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     4740

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4800

gcccgggcgg cctcagtgag cgagcgagcg cgcag                                4835


<210>  31
<211>  4874
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  UbC-cmyc-IL2-BChE C1-IRES-IL2-LPDN-SV40


<220>
<221>  repeat_region
<222>  (14)..(143)
<223>  5'ITR

<220>
<221>  promoter
<222>  (204)..(1430)
<223>  UbC promoter

<220>
<221>  Intron
<222>  (1524)..(1656)
<223>  Promega chimeric intron

<220>
<221>  misc_feature
<222>  (1770)..(3574)
<223>  BChE coding sequence C1

<220>
<221>  misc_feature
<222>  (1782)..(1838)
<223>  human IL2 leader sequence

<220>
<221>  misc_feature
<222>  (3572)..(4162)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4167)..(4446)
<223>  LPDN PRP

<220>
<221>  polyA_signal
<222>  (4449)..(4680)
<223>  SV40 late polyadenylation signal

<220>
<221>  repeat_region
<222>  (4745)..(4874)
<223>  5'ITR

<400>  31
ggccttaatt aggctgcgcg ctcgctcgct cactgaggcc gcccgggcaa agcccgggcg       60

tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag agggagtggc      120

caactccatc actaggggtt ccttgtagtt aatgattaac ccgccatgct acttatctac      180

gtagccatgc tctaggaaga tctggcctcc gcgccgggtt ttggcgcctc ccgcgggcgc      240

ccccctcctc acggcgagcg ctgccacgtc agacgaaggg cgcaggagcg tcctgatcct      300

tccgcccgga cgctcaggac agcggcccgc tgctcataag actcggcctt agaaccccag      360

tatcagcaga aggacatttt aggacgggac ttgggtgact ctagggcact ggttttcttt      420

ccagagagcg gaacaggcga ggaaaagtag tcccttctcg gcgattctgc ggagggatct      480

ccgtggggcg gtgaacgccg atgattatat aaggacgcgc cgggtgtggc acagctagtt      540

ccgtcgcagc cgggatttgg gtcgcggttc ttgtttgtgg atcgctgtga tcgtcacttg      600

gtgagtagcg ggctgctggg ctggccgggg ctttcgtggc cgccgggccg ctcggtggga      660

cggaagcgtg tggagagacc gccaagggct gtagtctggg tccgcgagca aggttgccct      720

gaactggggg ttggggggag cgcagcaaaa tggcggctgt tcccgagtct tgaatggaag      780

acgcttgtga ggcgggctgt gaggtcgttg aaacaaggtg gggggcatgg tgggcggcaa      840

gaacccaagg tcttgaggcc ttcgctaatg cgggaaagct cttattcggg tgagatgggc      900

tggggcacca tctggggacc ctgacgtgaa gtttgtcact gactggagaa ctcggtttgt      960

cgtctgttgc gggggcggca gttatgcggt gccgttgggc agtgcacccg tacctttggg     1020

agcgcgcgcc ctcgtcgtgt cgtgacgtca cccgttctgt tggcttataa tgcagggtgg     1080

ggccacctgc cggtaggtgt gcggtaggct tttctccgtc gcaggacgca gggttcgggc     1140

ctagggtagg ctctcctgaa tcgacaggcg ccggacctct ggtgagggga gggataagtg     1200

aggcgtcagt ttctttggtc ggttttatgt acctatcttc ttaagtagct gaagctccgg     1260

ttttgaacta tgcgctcggg gttggcgagt gtgttttgtg aagtttttta ggcacctttt     1320

gaaatgtaat catttgggtc aatatgtaat tttcagtgtt agactagtaa attgtccgct     1380

aaattctggc cgtttttggc ttttttgtta gacgaagctt tattgcggta gtttatcaca     1440

gttaaattgc taacgcagtc agtgcttctg acacaacagt ctcgaactta agctgcagaa     1500

gttggtcgtg aggcactggg caggtaagta tcaaggttac aagacaggtt taaggagacc     1560

aatagaaact gggcttgtcg agacagagaa gactcttgcg tttctgatag gcacctattg     1620

gtcttactga catccacttt gcctttctct ccacaggtgt ccactcccag ttcaattaca     1680

gctcttaagg ctagagtact taatacgact cactataggc tagcggggac tttgcactgg     1740

aacttacaac acccgagcaa ggacgcgact ctagacccac catgcggatg cagctgctgc     1800

tgctgattgc tctgagcctg gctctggtga ccaacagcga agacgacatt attattgcta     1860

ccaagaacgg caaggtgcgg ggcatgaacc tgaccgtgtt tggcggcacc gtgaccgctt     1920

ttctgggcat tccctatgct cagccccccc tgggccggct gcggtttaag aagccccaga     1980

gcctgaccaa gtggagcgac atttggaacg ctaccaagta tgctaacagc tgttgtcaga     2040

acattgacca gagctttccc ggctttcatg gcagcgaaat gtggaacccc aacaccgacc     2100

tgagcgaaga ctgtctgtat ctgaacgtgt ggattcccgc tcccaagccc aagaacgcta     2160

ccgtgctgat ttggatttat ggcggcggct ttcagaccgg caccagcagc ctgcatgtgt     2220

atgacggcaa gtttctggct cgggtggaac gggtgattgt ggtgagcatg aactatcggg     2280

tgggcgctct gggctttctg gctctgcccg gcaaccccga agctcccggc aacatgggcc     2340

tgtttgacca gcagctggct ctgcagtggg tgcagaagaa cattgctgct tttggcggca     2400

accccaagag cgtgaccctg tttggcgaaa gcgctggcgc tgctagcgtg agcctgcatc     2460

tgctgagccc cggcagccat agcctgttta cccgggctat tctgcagagc ggcagcttta     2520

acgctccctg ggctgtgacc agcctgtatg aagctcggaa ccggaccctg aacctggcta     2580

agctgaccgg ctgtagccgg gaaaacgaaa ccgaaattat taagtgtctg cggaacaagg     2640

acccccagga aattctgctg aacgaagctt ttgtggtgcc ctatggcacc cccctgagcg     2700

tgaactttgg ccccaccgtg gacggcgact ttctgaccga catgcccgac attctgctgg     2760

aactgggcca gtttaagaag acccagattc tggtgggcgt gaacaaggac gaaggcaccg     2820

cttttctggt gtatggcgct cccggcttta gcaaggacaa caacagcatt attacccgga     2880

aggaatttca ggaaggcctg aagatttttt ttcccggcgt gagcgaattt ggcaaggaaa     2940

gcattctgtt tcattatacc gactgggtgg acgaccagcg gcccgaaaac tatcgggaag     3000

ctctgggcga cgtggtgggc gactataact ttatttgtcc cgctctggaa tttaccaaga     3060

agtttagcga atggggcaac aacgcttttt tttattattt tgaacatcgg agcagcaagc     3120

tgccctggcc cgaatggatg ggcgtgatgc atggctatga aattgaattt gtgtttggcc     3180

tgcccctgga acggcgggac aactatacca aggctgaaga aattctgagc cggagcattg     3240

tgaagcggtg ggctaacttt gctaagtatg gcaaccccaa cgaaacccag aacaacagca     3300

ccagctggcc cgtgtttaag agcaccgaac agaagtatct gaccctgaac accgaaagca     3360

cccggattat gaccaagctg cgggctcagc agtgtcggtt ttggaccagc ttttttccca     3420

aggtgctgga aatgaccggc aacattgacg aagctgaatg ggaatggaag gctggctttc     3480

atcggtggaa caactatatg atggactgga agaaccagtt taacgactat accagcaaga     3540

aggaaagctg tgtgggcctg tgataaggcc ggcccctctc cctccccccc ccctaacgtt     3600

actggccgaa gccgcttgga ataaggccgg tgtgcgtttg tctatatgtt attttccacc     3660

atattgccgt cttttggcaa tgtgagggcc cggaaacctg gccctgtctt cttgacgagc     3720

attcctaggg gtctttcccc tctcgccaaa ggaatgcaag gtctgttgaa tgtcgtgaag     3780

gaagcagttc ctctggaagc ttcttgaaga caaacaacgt ctgtagcgac cctttgcagg     3840

cagcggaacc ccccacctgg cgacaggtgc ctctgcggcc aaaagccacg tgtataagat     3900

acacctgcaa aggcggcaca accccagtgc cacgttgtga gttggatagt tgtggaaaga     3960

gtcaaatggc tctcctcaag cgtattcaac aaggggctga aggatgccca gaaggtaccc     4020

cattgtatgg gatctgatct ggggcctcgg tacacatgct ttacatgtgt ttagtcgagg     4080

ttaaaaaaac gtctaggccc cccgaaccac ggggacgtgg ttttcctttg aaaaacacga     4140

tgataatatg gccacaacca tgtaccgcat gcaactcctg tcttgcattg cactaagtct     4200

tgcacttgtc acaaacagtc cacagccaaa gatcgtgacc ccatacaccg ccagccagcc     4260

aagcccacca ctgccaccac caccaccacc accaccacca ccaccaccac caccaccacc     4320

accaccacca ccactgccaa gccagagcgc cccaagcgcc ggaagcgccg ccccaatgtt     4380

cgtgaagtac agcaccatca cccggctgca gaacgccagc cagcacagcg gaaagcttgc     4440

ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa     4500

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     4560

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     4620

agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg     4680

ataaggatct tcctagagca tggctacgta gataagtagc atggcgggtt aatcattaac     4740

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4800

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4860

gagcgagcgc gcag                                                       4874


<210>  32
<211>  4965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7-cmyc-IL2-BChE C1-IRES-IL2-PRIMA1-rBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  promoter
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  enhancer
<222>  (279)..(538)
<223>  C4 enhancer with 2 mismatches

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  TATA_signal
<222>  (836)..(839)

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  Chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1941)..(3742)
<223>  BChE coding sequence C1

<220>
<221>  misc_feature
<222>  (1950)..(2006)
<223>  human IL2 leader sequence

<220>
<221>  misc_feature
<222>  (3740)..(4330)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4335)..(4560)
<223>  PRIMA1 PRP

<220>
<221>  polyA_signal
<222>  (4621)..(4747)
<223>  Rabbit beta globin polyA

<220>
<221>  repeat_region
<222>  (4836)..(4965)
<223>  3'ITR

<400>  32
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttaattcgct agacccacca tgcggatgca gctgctgctg ctgattgctc     1980

tgagcctggc tctggtgacc aacagcgaag acgacattat tattgctacc aagaacggca     2040

aggtgcgggg catgaacctg accgtgtttg gcggcaccgt gaccgctttt ctgggcattc     2100

cctatgctca gccccccctg ggccggctgc ggtttaagaa gccccagagc ctgaccaagt     2160

ggagcgacat ttggaacgct accaagtatg ctaacagctg ttgtcagaac attgaccaga     2220

gctttcccgg ctttcatggc agcgaaatgt ggaaccccaa caccgacctg agcgaagact     2280

gtctgtatct gaacgtgtgg attcccgctc ccaagcccaa gaacgctacc gtgctgattt     2340

ggatttatgg cggcggcttt cagaccggca ccagcagcct gcatgtgtat gacggcaagt     2400

ttctggctcg ggtggaacgg gtgattgtgg tgagcatgaa ctatcgggtg ggcgctctgg     2460

gctttctggc tctgcccggc aaccccgaag ctcccggcaa catgggcctg tttgaccagc     2520

agctggctct gcagtgggtg cagaagaaca ttgctgcttt tggcggcaac cccaagagcg     2580

tgaccctgtt tggcgaaagc gctggcgctg ctagcgtgag cctgcatctg ctgagccccg     2640

gcagccatag cctgtttacc cgggctattc tgcagagcgg cagctttaac gctccctggg     2700

ctgtgaccag cctgtatgaa gctcggaacc ggaccctgaa cctggctaag ctgaccggct     2760

gtagccggga aaacgaaacc gaaattatta agtgtctgcg gaacaaggac ccccaggaaa     2820

ttctgctgaa cgaagctttt gtggtgccct atggcacccc cctgagcgtg aactttggcc     2880

ccaccgtgga cggcgacttt ctgaccgaca tgcccgacat tctgctggaa ctgggccagt     2940

ttaagaagac ccagattctg gtgggcgtga acaaggacga aggcaccgct tttctggtgt     3000

atggcgctcc cggctttagc aaggacaaca acagcattat tacccggaag gaatttcagg     3060

aaggcctgaa gatttttttt cccggcgtga gcgaatttgg caaggaaagc attctgtttc     3120

attataccga ctgggtggac gaccagcggc ccgaaaacta tcgggaagct ctgggcgacg     3180

tggtgggcga ctataacttt atttgtcccg ctctggaatt taccaagaag tttagcgaat     3240

ggggcaacaa cgcttttttt tattattttg aacatcggag cagcaagctg ccctggcccg     3300

aatggatggg cgtgatgcat ggctatgaaa ttgaatttgt gtttggcctg cccctggaac     3360

ggcgggacaa ctataccaag gctgaagaaa ttctgagccg gagcattgtg aagcggtggg     3420

ctaactttgc taagtatggc aaccccaacg aaacccagaa caacagcacc agctggcccg     3480

tgtttaagag caccgaacag aagtatctga ccctgaacac cgaaagcacc cggattatga     3540

ccaagctgcg ggctcagcag tgtcggtttt ggaccagctt ttttcccaag gtgctggaaa     3600

tgaccggcaa cattgacgaa gctgaatggg aatggaaggc tggctttcat cggtggaaca     3660

actatatgat ggactggaag aaccagttta acgactatac cagcaagaag gaaagctgtg     3720

tgggcctgtg ataaggccgg cccctctccc tccccccccc ctaacgttac tggccgaagc     3780

cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct     3840

tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt     3900

ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct     3960

ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc     4020

ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag     4080

gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc     4140

tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga     4200

tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt     4260

ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc     4320

cacaaccatg taccgcatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac     4380

aaacagtcca cagaagagct gcagcaaggt gaccgatagc tgccggcacg tgtgccagtg     4440

ccggccacca ccaccactgc caccaccacc accacggctg ctgagcgccc cagccccaaa     4500

cagcaccagc tgcccaaccg aggagagctg gtggagcgga tgatgaaagc ttgcggccgc     4560

ggtacctcta gagtcgaccc gggcggcctc gaggacgggg tgaactacgc ctgaggatcc     4620

gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact     4680

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc     4740

tcactcggaa gcaattcgtt gatctgaatt tcgaccaccc ataataccca ttaccctggt     4800

agataagtag catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc     4860

cactccctct ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg     4920

cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg cgcag                     4965


<210>  33
<211>  5019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7-cmyc-IL2-BChE C1-IRES-IL2-LPDN-rBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (279)..(538)
<223>  C4 enhancer with 2 mismatches

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  TATA_signal
<222>  (836)..(839)

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  Chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1941)..(3739)
<223>  BChE conding sequence C1

<220>
<221>  misc_feature
<222>  (3740)..(4330)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4335)..(4614)
<223>  LPDN PRP

<220>
<221>  polyA_signal
<222>  (4675)..(4801)
<223>  Rabbit beta globin polyA

<220>
<221>  repeat_region
<222>  (4890)..(5019)

<400>  33
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttaattcgct agacccacca tgcggatgca gctgctgctg ctgattgctc     1980

tgagcctggc tctggtgacc aacagcgaag acgacattat tattgctacc aagaacggca     2040

aggtgcgggg catgaacctg accgtgtttg gcggcaccgt gaccgctttt ctgggcattc     2100

cctatgctca gccccccctg ggccggctgc ggtttaagaa gccccagagc ctgaccaagt     2160

ggagcgacat ttggaacgct accaagtatg ctaacagctg ttgtcagaac attgaccaga     2220

gctttcccgg ctttcatggc agcgaaatgt ggaaccccaa caccgacctg agcgaagact     2280

gtctgtatct gaacgtgtgg attcccgctc ccaagcccaa gaacgctacc gtgctgattt     2340

ggatttatgg cggcggcttt cagaccggca ccagcagcct gcatgtgtat gacggcaagt     2400

ttctggctcg ggtggaacgg gtgattgtgg tgagcatgaa ctatcgggtg ggcgctctgg     2460

gctttctggc tctgcccggc aaccccgaag ctcccggcaa catgggcctg tttgaccagc     2520

agctggctct gcagtgggtg cagaagaaca ttgctgcttt tggcggcaac cccaagagcg     2580

tgaccctgtt tggcgaaagc gctggcgctg ctagcgtgag cctgcatctg ctgagccccg     2640

gcagccatag cctgtttacc cgggctattc tgcagagcgg cagctttaac gctccctggg     2700

ctgtgaccag cctgtatgaa gctcggaacc ggaccctgaa cctggctaag ctgaccggct     2760

gtagccggga aaacgaaacc gaaattatta agtgtctgcg gaacaaggac ccccaggaaa     2820

ttctgctgaa cgaagctttt gtggtgccct atggcacccc cctgagcgtg aactttggcc     2880

ccaccgtgga cggcgacttt ctgaccgaca tgcccgacat tctgctggaa ctgggccagt     2940

ttaagaagac ccagattctg gtgggcgtga acaaggacga aggcaccgct tttctggtgt     3000

atggcgctcc cggctttagc aaggacaaca acagcattat tacccggaag gaatttcagg     3060

aaggcctgaa gatttttttt cccggcgtga gcgaatttgg caaggaaagc attctgtttc     3120

attataccga ctgggtggac gaccagcggc ccgaaaacta tcgggaagct ctgggcgacg     3180

tggtgggcga ctataacttt atttgtcccg ctctggaatt taccaagaag tttagcgaat     3240

ggggcaacaa cgcttttttt tattattttg aacatcggag cagcaagctg ccctggcccg     3300

aatggatggg cgtgatgcat ggctatgaaa ttgaatttgt gtttggcctg cccctggaac     3360

ggcgggacaa ctataccaag gctgaagaaa ttctgagccg gagcattgtg aagcggtggg     3420

ctaactttgc taagtatggc aaccccaacg aaacccagaa caacagcacc agctggcccg     3480

tgtttaagag caccgaacag aagtatctga ccctgaacac cgaaagcacc cggattatga     3540

ccaagctgcg ggctcagcag tgtcggtttt ggaccagctt ttttcccaag gtgctggaaa     3600

tgaccggcaa cattgacgaa gctgaatggg aatggaaggc tggctttcat cggtggaaca     3660

actatatgat ggactggaag aaccagttta acgactatac cagcaagaag gaaagctgtg     3720

tgggcctgtg ataaggccgg cccctctccc tccccccccc ctaacgttac tggccgaagc     3780

cgcttggaat aaggccggtg tgcgtttgtc tatatgttat tttccaccat attgccgtct     3840

tttggcaatg tgagggcccg gaaacctggc cctgtcttct tgacgagcat tcctaggggt     3900

ctttcccctc tcgccaaagg aatgcaaggt ctgttgaatg tcgtgaagga agcagttcct     3960

ctggaagctt cttgaagaca aacaacgtct gtagcgaccc tttgcaggca gcggaacccc     4020

ccacctggcg acaggtgcct ctgcggccaa aagccacgtg tataagatac acctgcaaag     4080

gcggcacaac cccagtgcca cgttgtgagt tggatagttg tggaaagagt caaatggctc     4140

tcctcaagcg tattcaacaa ggggctgaag gatgcccaga aggtacccca ttgtatggga     4200

tctgatctgg ggcctcggta cacatgcttt acatgtgttt agtcgaggtt aaaaaaacgt     4260

ctaggccccc cgaaccacgg ggacgtggtt ttcctttgaa aaacacgatg ataatatggc     4320

cacaaccatg taccgcatgc aactcctgtc ttgcattgca ctaagtcttg cacttgtcac     4380

aaacagtcca cagccaaaga tcgtgacccc atacaccgcc agccagccaa gcccaccact     4440

gccaccacca ccaccaccac caccaccacc accaccacca ccaccaccac caccaccacc     4500

actgccaagc cagagcgccc caagcgccgg aagcgccgcc ccaatgttcg tgaagtacag     4560

caccatcacc cggctgcaga acgccagcca gcacagcgga aagcttgcgg ccgcggtacc     4620

tctagagtcg acccgggcgg cctcgaggac ggggtgaact acgcctgagg atccgatctt     4680

tttccctctg ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc     4740

taataaagga aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc     4800

ggaagcaatt cgttgatctg aatttcgacc acccataata cccattaccc tggtagataa     4860

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     4920

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4980

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                            5019


<210>  34
<211>  4904
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4/Ubc hIL2 BChE C1 IRES LPDN


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (279)..(538)
<223>  C4 enhancer with 2 mismatches

<220>
<221>  promoter
<222>  (565)..(1791)
<223>  UbC promoter

<220>
<221>  misc_feature
<222>  (1826)..(3624)
<223>  BChE coding sequence C1

<220>
<221>  misc_feature
<222>  (3625)..(4215)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4220)..(4499)
<223>  LPDN PRP

<220>
<221>  polyA_signal
<222>  (4560)..(4686)
<223>  Rabbit beta globin polyA

<220>
<221>  repeat_region
<222>  (4775)..(4904)
<223>  3'ITR

<400>  34
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg atctggcctc cgcgccgggt tttggcgcct cccgcgggcg      600

cccccctcct cacggcgagc gctgccacgt cagacgaagg gcgcaggagc gtcctgatcc      660

ttccgcccgg acgctcagga cagcggcccg ctgctcataa gactcggcct tagaacccca      720

gtatcagcag aaggacattt taggacggga cttgggtgac tctagggcac tggttttctt      780

tccagagagc ggaacaggcg aggaaaagta gtcccttctc ggcgattctg cggagggatc      840

tccgtggggc ggtgaacgcc gatgattata taaggacgcg ccgggtgtgg cacagctagt      900

tccgtcgcag ccgggatttg ggtcgcggtt cttgtttgtg gatcgctgtg atcgtcactt      960

ggtgagtagc gggctgctgg gctggccggg gctttcgtgg ccgccgggcc gctcggtggg     1020

acggaagcgt gtggagagac cgccaagggc tgtagtctgg gtccgcgagc aaggttgccc     1080

tgaactgggg gttgggggga gcgcagcaaa atggcggctg ttcccgagtc ttgaatggaa     1140

gacgcttgtg aggcgggctg tgaggtcgtt gaaacaaggt ggggggcatg gtgggcggca     1200

agaacccaag gtcttgaggc cttcgctaat gcgggaaagc tcttattcgg gtgagatggg     1260

ctggggcacc atctggggac cctgacgtga agtttgtcac tgactggaga actcggtttg     1320

tcgtctgttg cgggggcggc agttatgcgg tgccgttggg cagtgcaccc gtacctttgg     1380

gagcgcgcgc cctcgtcgtg tcgtgacgtc acccgttctg ttggcttata atgcagggtg     1440

gggccacctg ccggtaggtg tgcggtaggc ttttctccgt cgcaggacgc agggttcggg     1500

cctagggtag gctctcctga atcgacaggc gccggacctc tggtgagggg agggataagt     1560

gaggcgtcag tttctttggt cggttttatg tacctatctt cttaagtagc tgaagctccg     1620

gttttgaact atgcgctcgg ggttggcgag tgtgttttgt gaagtttttt aggcaccttt     1680

tgaaatgtaa tcatttgggt caatatgtaa ttttcagtgt tagactagta aattgtccgc     1740

taaattctgg ccgtttttgg cttttttgtt agacgaagct tggtaccgag ctcggatcca     1800

ctagtccagt gtggtggaat tcgctagacc caccatgcgg atgcagctgc tgctgctgat     1860

tgctctgagc ctggctctgg tgaccaacag cgaagacgac attattattg ctaccaagaa     1920

cggcaaggtg cggggcatga acctgaccgt gtttggcggc accgtgaccg cttttctggg     1980

cattccctat gctcagcccc ccctgggccg gctgcggttt aagaagcccc agagcctgac     2040

caagtggagc gacatttgga acgctaccaa gtatgctaac agctgttgtc agaacattga     2100

ccagagcttt cccggctttc atggcagcga aatgtggaac cccaacaccg acctgagcga     2160

agactgtctg tatctgaacg tgtggattcc cgctcccaag cccaagaacg ctaccgtgct     2220

gatttggatt tatggcggcg gctttcagac cggcaccagc agcctgcatg tgtatgacgg     2280

caagtttctg gctcgggtgg aacgggtgat tgtggtgagc atgaactatc gggtgggcgc     2340

tctgggcttt ctggctctgc ccggcaaccc cgaagctccc ggcaacatgg gcctgtttga     2400

ccagcagctg gctctgcagt gggtgcagaa gaacattgct gcttttggcg gcaaccccaa     2460

gagcgtgacc ctgtttggcg aaagcgctgg cgctgctagc gtgagcctgc atctgctgag     2520

ccccggcagc catagcctgt ttacccgggc tattctgcag agcggcagct ttaacgctcc     2580

ctgggctgtg accagcctgt atgaagctcg gaaccggacc ctgaacctgg ctaagctgac     2640

cggctgtagc cgggaaaacg aaaccgaaat tattaagtgt ctgcggaaca aggaccccca     2700

ggaaattctg ctgaacgaag cttttgtggt gccctatggc acccccctga gcgtgaactt     2760

tggccccacc gtggacggcg actttctgac cgacatgccc gacattctgc tggaactggg     2820

ccagtttaag aagacccaga ttctggtggg cgtgaacaag gacgaaggca ccgcttttct     2880

ggtgtatggc gctcccggct ttagcaagga caacaacagc attattaccc ggaaggaatt     2940

tcaggaaggc ctgaagattt tttttcccgg cgtgagcgaa tttggcaagg aaagcattct     3000

gtttcattat accgactggg tggacgacca gcggcccgaa aactatcggg aagctctggg     3060

cgacgtggtg ggcgactata actttatttg tcccgctctg gaatttacca agaagtttag     3120

cgaatggggc aacaacgctt ttttttatta ttttgaacat cggagcagca agctgccctg     3180

gcccgaatgg atgggcgtga tgcatggcta tgaaattgaa tttgtgtttg gcctgcccct     3240

ggaacggcgg gacaactata ccaaggctga agaaattctg agccggagca ttgtgaagcg     3300

gtgggctaac tttgctaagt atggcaaccc caacgaaacc cagaacaaca gcaccagctg     3360

gcccgtgttt aagagcaccg aacagaagta tctgaccctg aacaccgaaa gcacccggat     3420

tatgaccaag ctgcgggctc agcagtgtcg gttttggacc agcttttttc ccaaggtgct     3480

ggaaatgacc ggcaacattg acgaagctga atgggaatgg aaggctggct ttcatcggtg     3540

gaacaactat atgatggact ggaagaacca gtttaacgac tataccagca agaaggaaag     3600

ctgtgtgggc ctgtgataag gccggcccct ctccctcccc cccccctaac gttactggcc     3660

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     3720

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     3780

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     3840

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     3900

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     3960

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     4020

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     4080

tgggatctga tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa     4140

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     4200

atggccacaa ccatgtaccg catgcaactc ctgtcttgca ttgcactaag tcttgcactt     4260

gtcacaaaca gtccacagcc aaagatcgtg accccataca ccgccagcca gccaagccca     4320

ccactgccac caccaccacc accaccacca ccaccaccac caccaccacc accaccacca     4380

ccaccactgc caagccagag cgccccaagc gccggaagcg ccgccccaat gttcgtgaag     4440

tacagcacca tcacccggct gcagaacgcc agccagcaca gcggaaagct tgcggccgcg     4500

gtacctctag agtcgacccg ggcggcctcg aggacggggt gaactacgcc tgaggatccg     4560

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     4620

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     4680

cactcggaag caattcgttg atctgaattt cgaccaccca taatacccat taccctggta     4740

gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc     4800

actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc     4860

ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag                      4904


<210>  35
<211>  4865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4/UbC hIL2 BuChE11 IRES PRIMA


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (279)..(538)
<223>  C4 enhancer with 2 mismatches

<220>
<221>  promoter
<222>  (565)..(1791)
<223>  UbC promoter

<220>
<221>  misc_feature
<222>  (1826)..(3624)
<223>  hBChE coding sequence C1

<220>
<221>  misc_signal
<222>  (1835)..(1891)
<223>  human IL2 leader sequence

<220>
<221>  misc_feature
<222>  (3625)..(4215)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4220)..(4460)
<223>  PRIMA1 PRP

<220>
<221>  polyA_signal
<222>  (4521)..(4647)
<223>  Rabbit beta globin polyA

<220>
<221>  repeat_region
<222>  (4736)..(4865)
<223>  3'ITR

<400>  35
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg atctggcctc cgcgccgggt tttggcgcct cccgcgggcg      600

cccccctcct cacggcgagc gctgccacgt cagacgaagg gcgcaggagc gtcctgatcc      660

ttccgcccgg acgctcagga cagcggcccg ctgctcataa gactcggcct tagaacccca      720

gtatcagcag aaggacattt taggacggga cttgggtgac tctagggcac tggttttctt      780

tccagagagc ggaacaggcg aggaaaagta gtcccttctc ggcgattctg cggagggatc      840

tccgtggggc ggtgaacgcc gatgattata taaggacgcg ccgggtgtgg cacagctagt      900

tccgtcgcag ccgggatttg ggtcgcggtt cttgtttgtg gatcgctgtg atcgtcactt      960

ggtgagtagc gggctgctgg gctggccggg gctttcgtgg ccgccgggcc gctcggtggg     1020

acggaagcgt gtggagagac cgccaagggc tgtagtctgg gtccgcgagc aaggttgccc     1080

tgaactgggg gttgggggga gcgcagcaaa atggcggctg ttcccgagtc ttgaatggaa     1140

gacgcttgtg aggcgggctg tgaggtcgtt gaaacaaggt ggggggcatg gtgggcggca     1200

agaacccaag gtcttgaggc cttcgctaat gcgggaaagc tcttattcgg gtgagatggg     1260

ctggggcacc atctggggac cctgacgtga agtttgtcac tgactggaga actcggtttg     1320

tcgtctgttg cgggggcggc agttatgcgg tgccgttggg cagtgcaccc gtacctttgg     1380

gagcgcgcgc cctcgtcgtg tcgtgacgtc acccgttctg ttggcttata atgcagggtg     1440

gggccacctg ccggtaggtg tgcggtaggc ttttctccgt cgcaggacgc agggttcggg     1500

cctagggtag gctctcctga atcgacaggc gccggacctc tggtgagggg agggataagt     1560

gaggcgtcag tttctttggt cggttttatg tacctatctt cttaagtagc tgaagctccg     1620

gttttgaact atgcgctcgg ggttggcgag tgtgttttgt gaagtttttt aggcaccttt     1680

tgaaatgtaa tcatttgggt caatatgtaa ttttcagtgt tagactagta aattgtccgc     1740

taaattctgg ccgtttttgg cttttttgtt agacgaagct tggtaccgag ctcggatcca     1800

ctagtccagt gtggtggaat tcgctagacc caccatgcgg atgcagctgc tgctgctgat     1860

tgctctgagc ctggctctgg tgaccaacag cgaagacgac attattattg ctaccaagaa     1920

cggcaaggtg cggggcatga acctgaccgt gtttggcggc accgtgaccg cttttctggg     1980

cattccctat gctcagcccc ccctgggccg gctgcggttt aagaagcccc agagcctgac     2040

caagtggagc gacatttgga acgctaccaa gtatgctaac agctgttgtc agaacattga     2100

ccagagcttt cccggctttc atggcagcga aatgtggaac cccaacaccg acctgagcga     2160

agactgtctg tatctgaacg tgtggattcc cgctcccaag cccaagaacg ctaccgtgct     2220

gatttggatt tatggcggcg gctttcagac cggcaccagc agcctgcatg tgtatgacgg     2280

caagtttctg gctcgggtgg aacgggtgat tgtggtgagc atgaactatc gggtgggcgc     2340

tctgggcttt ctggctctgc ccggcaaccc cgaagctccc ggcaacatgg gcctgtttga     2400

ccagcagctg gctctgcagt gggtgcagaa gaacattgct gcttttggcg gcaaccccaa     2460

gagcgtgacc ctgtttggcg aaagcgctgg cgctgctagc gtgagcctgc atctgctgag     2520

ccccggcagc catagcctgt ttacccgggc tattctgcag agcggcagct ttaacgctcc     2580

ctgggctgtg accagcctgt atgaagctcg gaaccggacc ctgaacctgg ctaagctgac     2640

cggctgtagc cgggaaaacg aaaccgaaat tattaagtgt ctgcggaaca aggaccccca     2700

ggaaattctg ctgaacgaag cttttgtggt gccctatggc acccccctga gcgtgaactt     2760

tggccccacc gtggacggcg actttctgac cgacatgccc gacattctgc tggaactggg     2820

ccagtttaag aagacccaga ttctggtggg cgtgaacaag gacgaaggca ccgcttttct     2880

ggtgtatggc gctcccggct ttagcaagga caacaacagc attattaccc ggaaggaatt     2940

tcaggaaggc ctgaagattt tttttcccgg cgtgagcgaa tttggcaagg aaagcattct     3000

gtttcattat accgactggg tggacgacca gcggcccgaa aactatcggg aagctctggg     3060

cgacgtggtg ggcgactata actttatttg tcccgctctg gaatttacca agaagtttag     3120

cgaatggggc aacaacgctt ttttttatta ttttgaacat cggagcagca agctgccctg     3180

gcccgaatgg atgggcgtga tgcatggcta tgaaattgaa tttgtgtttg gcctgcccct     3240

ggaacggcgg gacaactata ccaaggctga agaaattctg agccggagca ttgtgaagcg     3300

gtgggctaac tttgctaagt atggcaaccc caacgaaacc cagaacaaca gcaccagctg     3360

gcccgtgttt aagagcaccg aacagaagta tctgaccctg aacaccgaaa gcacccggat     3420

tatgaccaag ctgcgggctc agcagtgtcg gttttggacc agcttttttc ccaaggtgct     3480

ggaaatgacc ggcaacattg acgaagctga atgggaatgg aaggctggct ttcatcggtg     3540

gaacaactat atgatggact ggaagaacca gtttaacgac tataccagca agaaggaaag     3600

ctgtgtgggc ctgtgataag gccggcccct ctccctcccc cccccctaac gttactggcc     3660

gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc     3720

cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta     3780

ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag     3840

ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga     3900

accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg     3960

caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat     4020

ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta     4080

tgggatctga tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa     4140

aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat     4200

atggccacaa ccatgtaccg catgcaactc ctgtcttgca ttgcactaag tcttgcactt     4260

gtcacaaaca gtccacagaa gagctgcagc aaggtgaccg atagctgccg gcacgtgtgc     4320

cagtgccggc caccaccacc actgccacca ccaccaccac caccaccacc accacggctg     4380

ctgagcgccc cagccccaaa cagcaccagc tgcccaaccg aggagagctg gtggagcgga     4440

tgatgaaagc ttgcggccgc ggtacctcta gagtcgaccc gggcggcctc gaggacgggg     4500

tgaactacgc ctgaggatcc gatctttttc cctctgccaa aaattatggg gacatcatga     4560

agccccttga gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt     4620

gttggaattt tttgtgtctc tcactcggaa gcaattcgtt gatctgaatt tcgaccaccc     4680

ataataccca ttaccctggt agataagtag catggcgggt taatcattaa ctacaaggaa     4740

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg     4800

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg     4860

cgcag                                                                 4865


<210>  36
<211>  4254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hBChE C4


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  ITR

<220>
<221>  misc_feature
<222>  (87)..(828)
<223>  human CMV IE enhancer and promoter

<220>
<221>  TATA_signal
<222>  (793)..(797)

<220>
<221>  Intron
<222>  (943)..(1075)
<223>  Promega chimeric intron

<220>
<221>  misc_feature
<222>  (1189)..(2993)
<223>  hBChE C4

<220>
<221>  misc_feature
<222>  (2991)..(3581)
<223>  IRES

<220>
<221>  misc_feature
<222>  (3586)..(3826)
<223>  PRIMA1 PRP

<220>
<221>  polyA
<222>  (3829)..(4060)
<223>  SV40 late polyA

<220>
<221>  misc_feature
<222>  (4125)..(4254)
<223>  ITR

<400>  36
ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc       60

tacgtagcca tgctctagga agatcttcaa tattggccat tagccatatt attcattggt      120

tatatagcat aaatcaatat tggctattgg ccattgcata cgttgtatct atatcataat      180

atgtacattt atattggctc atgtccaata tgaccgccat gttggcattg attattgact      240

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc      300

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg      360

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa      420

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca      480

agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac      540

atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc      600

atggtgatgc ggttttggca gtacaccaat gggcgtggat agcggtttga ctcacgggga      660

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg      720

gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta      780

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac tagaagcttt      840

attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga cacaacagtc      900

tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat caaggttaca      960

agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt     1020

ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc cacaggtgtc     1080

cactcccagt tcaattacag ctcttaaggc tagagtactt aatacgactc actataggct     1140

agcggggact ttgcactgga acttacaaca cccgagcaag gacgcgactc tagacccacc     1200

atgagaatgc aacttcttct tcttattgca ctttcacttg cacttgttac aaattcagaa     1260

gatgatatta ttattgcaac aaaaaatgga aaagttagag gaatgaatct tacagttttc     1320

ggaggaacag ttacagcatt ccttggaatt ccatatgcac aaccaccact tggaagactt     1380

agattcaaaa aaccacaatc acttacaaaa tggtcagata tttggaatgc aacaaaatat     1440

gcaaattcat gttgtcaaaa tattgatcaa tcattcccag gattccatgg atcagaaatg     1500

tggaatccaa atacagatct ttcagaagat tgtctttatc ttaatgtttg gattccagca     1560

ccaaaaccaa aaaatgcaac agttcttatt tggatttatg gaggaggatt ccaaacagga     1620

acatcatcac ttcatgttta tgatggaaaa ttccttgcaa gagttgaaag agttattgtt     1680

gtttcaatga attatagagt tggagcactt ggattccttg cacttccagg aaatccagaa     1740

gcaccaggaa atatgggact tttcgatcaa caacttgcac ttcaatgggt tcaaaaaaat     1800

attgcagcat tcggaggaaa tccaaaatca gttacacttt tcggagaatc agcaggagca     1860

gcatcagttt cacttcatct tctttcacca ggatcacatt cacttttcac aagagcaatt     1920

cttcaatcag gatcattcaa tgcaccatgg gcagttacat cactttatga agcaagaaat     1980

agaacactta atcttgcaaa acttacagga tgttcaagag aaaatgaaac agaaattatt     2040

aaatgtctta gaaataaaga tccacaagaa attcttctta atgaagcatt cgttgttcca     2100

tatggaacac cactttcagt taatttcgga ccaacagttg atggagattt ccttacagat     2160

atgccagata ttcttcttga acttggacaa ttcaaaaaaa cacaaattct tgttggagtt     2220

aataaagatg aaggaacagc attccttgtt tatggagcac caggattctc aaaagataat     2280

aattcaatta ttacaagaaa agaattccaa gaaggactta aaattttctt cccaggagtt     2340

tcagaattcg gaaaagaatc aattcttttc cattatacag attgggttga tgatcaaaga     2400

ccagaaaatt atagagaagc acttggagat gttgttggag attataattt catttgtcca     2460

gcacttgaat tcacaaaaaa attctcagaa tggggaaata atgcattctt ctattatttc     2520

gaacatagat catcaaaact tccatggcca gaatggatgg gagttatgca tggatatgaa     2580

attgaattcg ttttcggact tccacttgaa agaagagata attatacaaa agcagaagaa     2640

attctttcaa gatcaattgt taaaagatgg gcaaatttcg caaaatatgg aaatccaaat     2700

gaaacacaaa ataattcaac atcatggcca gttttcaaat caacagaaca aaaatatctt     2760

acacttaata cagaatcaac aagaattatg acaaaactta gagcacaaca atgtagattc     2820

tggacatcat tcttcccaaa agttcttgaa atgacaggaa atattgatga agcagaatgg     2880

gaatggaaag caggattcca tagatggaat aattatatga tggattggaa aaatcaattc     2940

aatgattata catcaaaaaa agaatcatgt gttggacttt gataaggccg gcccctctcc     3000

ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt gtgcgtttgt     3060

ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc ggaaacctgg     3120

ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag gaatgcaagg     3180

tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac aaacaacgtc     3240

tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc tctgcggcca     3300

aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag     3360

ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca aggggctgaa     3420

ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt acacatgctt     3480

tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt     3540

tttcctttga aaaacacgat gataatatgg ccacaaccat gtaccgcatg caactcctgt     3600

cttgcattgc actaagtctt gcacttgtca caaacagtcc acagaagagc tgcagcaagg     3660

tgaccgatag ctgccggcac gtgtgccagt gccggccacc accaccactg ccaccaccac     3720

caccaccacc accaccacca cggctgctga gcgccccagc cccaaacagc accagctgcc     3780

caaccgagga gagctggtgg agcggatgat gaaagcttgc ggccgcttcg agcagacatg     3840

ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     3900

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     3960

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt     4020

ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg ataaggatct tcctagagca     4080

tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     4140

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     4200

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           4254


<210>  37
<211>  7254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV.hBChE C5.IRES.PRIMA1.


<220>
<221>  misc_feature
<222>  (87)..(828)
<223>  human CMV IE enahncer promoter

<220>
<221>  TATA_signal
<222>  (793)..(797)

<220>
<221>  Intron
<222>  (943)..(1075)
<223>  promoga chimeric intron

<220>
<221>  misc_feature
<222>  (1189)..(2993)
<223>  hBChE C5

<220>
<221>  misc_feature
<222>  (2991)..(3581)
<223>  IRES

<220>
<221>  misc_feature
<222>  (3586)..(3826)
<223>  PRIMA1 PRP

<220>
<221>  polyA_signal
<222>  (3829)..(4060)
<223>  SV40 late polyA

<220>
<221>  misc_feature
<222>  (4125)..(4254)
<223>  ITR

<400>  37
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat      360

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg      420

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt      480

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      540

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg      600

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact      660

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt      720

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc      780

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc      840

gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata      900

taagcagagc tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc      960

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca     1020

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag     1080

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta     1140

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt     1200

acagctctta aggctagagt acttaatacg actcactata ggctagcggg gactttgcac     1260

tggaacttac aacacccgag caaggacgcg actctagacc caccatgcgt atgcagctgc     1320

tgctgctgat tgcgctgagc ctggcgctgg tgaccaacag cgaagatgat attattattg     1380

cgaccaaaaa cggcaaagtg cgtggcatga acctgaccgt gtttggcggc accgtgaccg     1440

cgtttctggg cattccgtat gcgcagccgc cgctgggccg tctgcgtttt aaaaaaccgc     1500

agagcctgac caaatggagc gatatttgga acgcgaccaa atatgcgaac agctgctgcc     1560

agaacattga tcagagcttt ccgggctttc atggcagcga aatgtggaac ccgaacaccg     1620

atctgagcga agattgcctg tatctgaacg tgtggattcc ggcgccgaaa ccgaaaaacg     1680

cgaccgtgct gatttggatt tatggcggcg gctttcagac cggcaccagc agcctgcatg     1740

tgtatgatgg caaatttctg gcgcgtgtgg aacgtgtgat tgtggtgagc atgaactatc     1800

gtgtgggcgc gctgggcttt ctggcgctgc cgggcaaccc ggaagcgccg ggcaacatgg     1860

gcctgtttga tcagcagctg gcgctgcagt gggtgcagaa aaacattgcg gcgtttggcg     1920

gcaacccgaa aagcgtgacc ctgtttggcg aaagcgcggg cgcggcgagc gtgagcctgc     1980

atctgctgag cccgggcagc catagcctgt ttacccgtgc gattctgcag agcggcagct     2040

ttaacgcgcc gtgggcggtg accagcctgt atgaagcgcg taaccgtacc ctgaacctgg     2100

cgaaactgac cggctgcagc cgtgaaaacg aaaccgaaat tattaaatgc ctgcgtaaca     2160

aagatccgca ggaaattctg ctgaacgaag cgtttgtggt gccgtatggc accccgctga     2220

gcgtgaactt tggcccgacc gtggatggcg attttctgac cgatatgccg gatattctgc     2280

tggaactggg ccagtttaaa aaaacccaga ttctggtggg cgtgaacaaa gatgaaggca     2340

ccgcgtttct ggtgtatggc gcgccgggct ttagcaaaga taacaacagc attattaccc     2400

gtaaagaatt tcaggaaggc ctgaaaattt tttttccggg cgtgagcgaa tttggcaaag     2460

aaagcattct gtttcattat accgattggg tggatgatca gcgtccggaa aactatcgtg     2520

aagcgctggg cgatgtggtg ggcgattata actttatttg cccggcgctg gaatttacca     2580

aaaaatttag cgaatggggc aacaacgcgt ttttttatta ttttgaacat cgtagcagca     2640

aactgccgtg gccggaatgg atgggcgtga tgcatggcta tgaaattgaa tttgtgtttg     2700

gcctgccgct ggaacgtcgt gataactata ccaaagcgga agaaattctg agccgtagca     2760

ttgtgaaacg ttgggcgaac tttgcgaaat atggcaaccc gaacgaaacc cagaacaaca     2820

gcaccagctg gccggtgttt aaaagcaccg aacagaaata tctgaccctg aacaccgaaa     2880

gcacccgtat tatgaccaaa ctgcgtgcgc agcagtgccg tttttggacc agcttttttc     2940

cgaaagtgct ggaaatgacc ggcaacattg atgaagcgga atgggaatgg aaagcgggct     3000

ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc     3060

tacgtagcca tgctctagga agatcttcaa tattggccat tagccatatt attcattggt     3120

tatatagcat aaatcaatat tggctattgg ccattgcata cgttgtatct atatcataat     3180

atgtacattt atattggctc atgtccaata tgaccgccat gttggcattg attattgact     3240

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc     3300

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg     3360

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa     3420

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca     3480

agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac     3540

atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc     3600

atggtgatgc ggttttggca gtacaccaat gggcgtggat agcggtttga ctcacgggga     3660

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg     3720

gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta     3780

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac tagaagcttt     3840

attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga cacaacagtc     3900

tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat caaggttaca     3960

agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt     4020

ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc cacaggtgtc     4080

cactcccagt tcaattacag ctcttaaggc tagagtactt aatacgactc actataggct     4140

agcggggact ttgcactgga acttacaaca cccgagcaag gacgcgactc tagacccacc     4200

atgcgtatgc agctgctgct gctgattgcg ctgagcctgg cgctggtgac caacagcgaa     4260

gatgatatta ttattgcgac caaaaacggc aaagtgcgtg gcatgaacct gaccgtgttt     4320

ggcggcaccg tgaccgcgtt tctgggcatt ccgtatgcgc agccgccgct gggccgtctg     4380

cgttttaaaa aaccgcagag cctgaccaaa tggagcgata tttggaacgc gaccaaatat     4440

gcgaacagct gctgccagaa cattgatcag agctttccgg gctttcatgg cagcgaaatg     4500

tggaacccga acaccgatct gagcgaagat tgcctgtatc tgaacgtgtg gattccggcg     4560

ccgaaaccga aaaacgcgac cgtgctgatt tggatttatg gcggcggctt tcagaccggc     4620

accagcagcc tgcatgtgta tgatggcaaa tttctggcgc gtgtggaacg tgtgattgtg     4680

gtgagcatga actatcgtgt gggcgcgctg ggctttctgg cgctgccggg caacccggaa     4740

gcgccgggca acatgggcct gtttgatcag cagctggcgc tgcagtgggt gcagaaaaac     4800

attgcggcgt ttggcggcaa cccgaaaagc gtgaccctgt ttggcgaaag cgcgggcgcg     4860

gcgagcgtga gcctgcatct gctgagcccg ggcagccata gcctgtttac ccgtgcgatt     4920

ctgcagagcg gcagctttaa cgcgccgtgg gcggtgacca gcctgtatga agcgcgtaac     4980

cgtaccctga acctggcgaa actgaccggc tgcagccgtg aaaacgaaac cgaaattatt     5040

aaatgcctgc gtaacaaaga tccgcaggaa attctgctga acgaagcgtt tgtggtgccg     5100

tatggcaccc cgctgagcgt gaactttggc ccgaccgtgg atggcgattt tctgaccgat     5160

atgccggata ttctgctgga actgggccag tttaaaaaaa cccagattct ggtgggcgtg     5220

aacaaagatg aaggcaccgc gtttctggtg tatggcgcgc cgggctttag caaagataac     5280

aacagcatta ttacccgtaa agaatttcag gaaggcctga aaattttttt tccgggcgtg     5340

agcgaatttg gcaaagaaag cattctgttt cattataccg attgggtgga tgatcagcgt     5400

ccggaaaact atcgtgaagc gctgggcgat gtggtgggcg attataactt tatttgcccg     5460

gcgctggaat ttaccaaaaa atttagcgaa tggggcaaca acgcgttttt ttattatttt     5520

gaacatcgta gcagcaaact gccgtggccg gaatggatgg gcgtgatgca tggctatgaa     5580

attgaatttg tgtttggcct gccgctggaa cgtcgtgata actataccaa agcggaagaa     5640

attctgagcc gtagcattgt gaaacgttgg gcgaactttg cgaaatatgg caacccgaac     5700

gaaacccaga acaacagcac cagctggccg gtgtttaaaa gcaccgaaca gaaatatctg     5760

accctgaaca ccgaaagcac ccgtattatg accaaactgc gtgcgcagca gtgccgtttt     5820

tggaccagct tttttccgaa agtgctggaa atgaccggca acattgatga agcggaatgg     5880

gaatggaaag cgggctttca tcgttggaac aactatatga tggattggaa aaaccagttt     5940

aacgattata ccagcaaaaa agaaagctgc gtgggcctgt gataaggccg gcccctctcc     6000

ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt gtgcgtttgt     6060

ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc ggaaacctgg     6120

ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag gaatgcaagg     6180

tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac aaacaacgtc     6240

tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc tctgcggcca     6300

aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag     6360

ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca aggggctgaa     6420

ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt acacatgctt     6480

tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt     6540

tttcctttga aaaacacgat gataatatgg ccacaaccat gtaccgcatg caactcctgt     6600

cttgcattgc actaagtctt gcacttgtca caaacagtcc acagaagagc tgcagcaagg     6660

tgaccgatag ctgccggcac gtgtgccagt gccggccacc accaccactg ccaccaccac     6720

caccaccacc accaccacca cggctgctga gcgccccagc cccaaacagc accagctgcc     6780

caaccgagga gagctggtgg agcggatgat gaaagcttgc ggccgcttcg agcagacatg     6840

ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     6900

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     6960

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt     7020

ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg ataaggatct tcctagagca     7080

tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     7140

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     7200

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           7254


<210>  38
<211>  4254
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV.hBChE C7.IRES.PRIMA1


<220>
<221>  misc_feature
<222>  (87)..(828)
<223>  human CMV IE enhancer/promoter

<220>
<221>  TATA_signal
<222>  (793)..(797)

<220>
<221>  Intron
<222>  (943)..(1075)
<223>  Promega chimeric intron

<220>
<221>  misc_feature
<222>  (1189)..(2993)
<223>  hBChE C7

<220>
<221>  misc_feature
<222>  (2991)..(3581)
<223>  IRES

<220>
<221>  misc_feature
<222>  (3586)..(3826)
<223>  PRIMA1 PRP

<220>
<221>  polyA_signal
<222>  (3829)..(4060)
<223>  SV40 late polyA signal

<220>
<221>  misc_feature
<222>  (4125)..(4254)
<223>  ITR

<400>  38
ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc       60

tacgtagcca tgctctagga agatcttcaa tattggccat tagccatatt attcattggt      120

tatatagcat aaatcaatat tggctattgg ccattgcata cgttgtatct atatcataat      180

atgtacattt atattggctc atgtccaata tgaccgccat gttggcattg attattgact      240

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc      300

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg      360

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa      420

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca      480

agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac      540

atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc      600

atggtgatgc ggttttggca gtacaccaat gggcgtggat agcggtttga ctcacgggga      660

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg      720

gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta      780

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac tagaagcttt      840

attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga cacaacagtc      900

tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat caaggttaca      960

agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt     1020

ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc cacaggtgtc     1080

cactcccagt tcaattacag ctcttaaggc tagagtactt aatacgactc actataggct     1140

agcggggact ttgcactgga acttacaaca cccgagcaag gacgcgactc tagacccacc     1200

atgagaatgc aattattatt attaattgca ttatcattag cattagttac aaattcagaa     1260

gatgatatta ttattgcaac aaaaaatggt aaagttagag gtatgaattt aacagttttt     1320

ggtggtacag ttacagcatt tttaggtatt ccatatgcac aaccaccatt aggtagatta     1380

agatttaaaa aaccacaatc attaacaaaa tggtcagata tttggaatgc aacaaaatat     1440

gcaaattcat gttgtcaaaa tattgatcaa tcatttccag gttttcatgg ttcagaaatg     1500

tggaatccaa atacagattt atcagaagat tgtttatatt taaatgtttg gattccagca     1560

ccaaaaccaa aaaatgcaac agttttaatt tggatttatg gtggtggttt tcaaacaggt     1620

acatcatcat tacatgttta tgatggtaaa tttttagcaa gagttgaaag agttattgtt     1680

gtttcaatga attatagagt tggtgcatta ggttttttag cattaccagg taatccagaa     1740

gcaccaggta atatgggttt atttgatcaa caattagcat tacaatgggt tcaaaaaaat     1800

attgcagcat ttggtggtaa tccaaaatca gttacattat ttggtgaatc agcaggtgca     1860

gcatcagttt cattacattt attatcacca ggttcacatt cattatttac aagagcaatt     1920

ttacaatcag gttcatttaa tgcaccatgg gcagttacat cattatatga agcaagaaat     1980

agaacattaa atttagcaaa attaacaggt tgttcaagag aaaatgaaac agaaattatt     2040

aaatgtttaa gaaataaaga tccacaagaa attttattaa atgaagcatt tgttgttcca     2100

tatggtacac cattatcagt taattttggt ccaacagttg atggtgattt tttaacagat     2160

atgccagata ttttattaga attaggtcaa tttaaaaaaa cacaaatttt agttggtgtt     2220

aataaagatg aaggtacagc atttttagtt tatggtgcac caggtttttc aaaagataat     2280

aattcaatta ttacaagaaa agaatttcaa gaaggtttaa aaattttttt tccaggtgtt     2340

tcagaatttg gtaaagaatc aattttattt cattatacag attgggttga tgatcaaaga     2400

ccagaaaatt atagagaagc attaggtgat gttgttggtg attataattt tatttgtcca     2460

gcattagaat ttacaaaaaa attttcagaa tggggtaata atgcattttt ttattatttt     2520

gaacatagat catcaaaatt accatggcca gaatggatgg gtgttatgca tggttatgaa     2580

attgaatttg tttttggttt accattagaa agaagagata attatacaaa agcagaagaa     2640

attttatcaa gatcaattgt taaaagatgg gcaaattttg caaaatatgg taatccaaat     2700

gaaacacaaa ataattcaac atcatggcca gtttttaaat caacagaaca aaaatattta     2760

acattaaata cagaatcaac aagaattatg acaaaattaa gagcacaaca atgtagattt     2820

tggacatcat tttttccaaa agttttagaa atgacaggta atattgatga agcagaatgg     2880

gaatggaaag caggttttca tagatggaat aattatatga tggattggaa aaatcaattt     2940

aatgattata catcaaaaaa agaatcatgt gttggtttat gataaggccg gcccctctcc     3000

ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt gtgcgtttgt     3060

ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc ggaaacctgg     3120

ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag gaatgcaagg     3180

tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac aaacaacgtc     3240

tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc tctgcggcca     3300

aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag     3360

ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca aggggctgaa     3420

ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt acacatgctt     3480

tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt     3540

tttcctttga aaaacacgat gataatatgg ccacaaccat gtaccgcatg caactcctgt     3600

cttgcattgc actaagtctt gcacttgtca caaacagtcc acagaagagc tgcagcaagg     3660

tgaccgatag ctgccggcac gtgtgccagt gccggccacc accaccactg ccaccaccac     3720

caccaccacc accaccacca cggctgctga gcgccccagc cccaaacagc accagctgcc     3780

caaccgagga gagctggtgg agcggatgat gaaagcttgc ggccgcttcg agcagacatg     3840

ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     3900

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     3960

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt     4020

ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg ataaggatct tcctagagca     4080

tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     4140

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     4200

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           4254


<210>  39
<211>  7134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hBChE plasmid


<220>
<221>  misc_feature
<222>  (87)..(828)
<223>  human CMV IE enhancer/promoter

<220>
<221>  TATA_signal
<222>  (793)..(797)

<220>
<221>  Intron
<222>  (943)..(1075)
<223>  Promega chimeric intron

<220>
<221>  misc_feature
<222>  (1144)..(1189)
<223>  c-myc mini-IRES

<220>
<221>  misc_feature
<222>  (1190)..(2991)
<223>  hBChE C117H E197Q with human IL2 leader sequence

<220>
<221>  misc_feature
<222>  (2992)..(3581)
<223>  IRES

<220>
<221>  polyA_signal
<222>  (3829)..(4060)
<223>  SV40 late polyA

<220>
<221>  misc_feature
<222>  (4125)..(4254)
<223>  ITR

<400>  39
ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc       60

tacgtagcca tgctctagga agatcttcaa tattggccat tagccatatt attcattggt      120

tatatagcat aaatcaatat tggctattgg ccattgcata cgttgtatct atatcataat      180

atgtacattt atattggctc atgtccaata tgaccgccat gttggcattg attattgact      240

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc      300

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg      360

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa      420

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca      480

agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac      540

atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc      600

atggtgatgc ggttttggca gtacaccaat gggcgtggat agcggtttga ctcacgggga      660

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg      720

gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta      780

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac tagaagcttt      840

attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga cacaacagtc      900

tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat caaggttaca      960

agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt     1020

ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc cacaggtgtc     1080

cactcccagt tcaattacag ctcttaaggc tagagtactt aatacgactc actataggct     1140

agcggggact ttgcactgga acttacaaca cccgagcaag gacgcgactc tagacccacc     1200

atgcggatgc agctgctgct gctgatcgcc ctgagcctgg ccctggtgac caacagcgag     1260

gatgatatca tcatcgccac caagaacgga aaggtgcggg gaatgaacct gaccgtgttc     1320

ggaggaaccg tgaccgcctt cctgggaatc ccatacgccc agccaccact gggacggctg     1380

cggttcaaga agccacagag cctgaccaag tggagcgata tctggaacgc caccaagtac     1440

gccaacagct gctgccagaa catcgatcag agcttcccag gattccacgg aagcgagatg     1500

tggaacccaa acaccgatct gagcgaggat tgcctgtacc tgaacgtgtg gatcccagcc     1560

ccaaagccaa agaacgccac cgtgctgatc tggatctacg gaggacactt ccagaccgga     1620

accagcagcc tgcacgtgta cgatggaaag ttcctggccc gggtggagcg ggtgatcgtg     1680

gtgagcatga actaccgggt gggagccctg ggattcctgg ccctgccagg aaacccagag     1740

gccccaggaa acatgggact gttcgatcag cagctggccc tgcagtgggt gcagaagaac     1800

atcgccgcct tcggaggaaa cccaaagagc gtgaccctgt tcggacagag cgccggagcc     1860

gccagcgtga gcctgcacct gctgagccca ggaagccaca gcctgttcac ccgggccatc     1920

ctgcagagcg gaagcttcaa cgccccatgg gccgtgacca gcctgtacga ggcccggaac     1980

cggaccctga acctggccaa gctgaccgga tgcagccggg agaacgagac cgagatcatc     2040

aagtgcctgc ggaacaagga tccacaggag atcctgctga acgaggcctt cgtggtgcca     2100

tacggaaccc cactgagcgt gaacttcgga ccaaccgtgg atggagattt cctgaccgat     2160

atgccagata tcctgctgga gctgggacag ttcaagaaga cccagatcct ggtgggagtg     2220

aacaaggatg agggaaccgc cttcctggtg tacggagccc caggattcag caaggataac     2280

aacagcatca tcacccggaa ggagttccag gagggactga agatcttctt cccaggagtg     2340

agcgagttcg gaaaggagag catcctgttc cactacaccg attgggtgga tgatcagcgg     2400

ccagagaact accgggaggc cctgggagat gtggtgggag attacaactt catctgccca     2460

gccctggagt tcaccaagaa gttcagcgag tggggaaaca acgccttctt ctactacttc     2520

gagcaccgga gcagcaagct gccatggcca gagtggatgg gagtgatgca cggatacgag     2580

atcgagttcg tgttcggact gccactggag cggcgggata actacaccaa ggccgaggag     2640

atcctgagcc ggagcatcgt gaagcggtgg gccaacttcg ccaagtacgg aaacccaaac     2700

gagacccaga acaacagcac cagctggcca gtgttcaaga gcaccgagca gaagtacctg     2760

ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt     2820

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtaccctg aacaccgaga     2880

ggccaactcc atcactaggg gttccttgta gttaatgatt aacccgccat gctacttatc     2940

tacgtagcca tgctctagga agatcttcaa tattggccat tagccatatt attcattggt     3000

tatatagcat aaatcaatat tggctattgg ccattgcata cgttgtatct atatcataat     3060

atgtacattt atattggctc atgtccaata tgaccgccat gttggcattg attattgact     3120

agttattaat agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc     3180

gttacataac ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg     3240

acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa     3300

tgggtggagt atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca     3360

agtccgcccc ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac     3420

atgaccttac gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc     3480

atggtgatgc ggttttggca gtacaccaat gggcgtggat agcggtttga ctcacgggga     3540

tttccaagtc tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg     3600

gactttccaa aatgtcgtaa taaccccgcc ccgttgacgc aaatgggcgg taggcgtgta     3660

cggtgggagg tctatataag cagagctcgt ttagtgaacc gtcagatcac tagaagcttt     3720

attgcggtag tttatcacag ttaaattgct aacgcagtca gtgcttctga cacaacagtc     3780

tcgaacttaa gctgcagaag ttggtcgtga ggcactgggc aggtaagtat caaggttaca     3840

agacaggttt aaggagacca atagaaactg ggcttgtcga gacagagaag actcttgcgt     3900

ttctgatagg cacctattgg tcttactgac atccactttg cctttctctc cacaggtgtc     3960

cactcccagt tcaattacag ctcttaaggc tagagtactt aatacgactc actataggct     4020

agcggggact ttgcactgga acttacaaca cccgagcaag gacgcgactc tagacccacc     4080

atgcggatgc agctgctgct gctgatcgcc ctgagcctgg ccctggtgac caacagcgag     4140

gatgatatca tcatcgccac caagaacgga aaggtgcggg gaatgaacct gaccgtgttc     4200

ggaggaaccg tgaccgcctt cctgggaatc ccatacgccc agccaccact gggacggctg     4260

cggttcaaga agccacagag cctgaccaag tggagcgata tctggaacgc caccaagtac     4320

gccaacagct gctgccagaa catcgatcag agcttcccag gattccacgg aagcgagatg     4380

tggaacccaa acaccgatct gagcgaggat tgcctgtacc tgaacgtgtg gatcccagcc     4440

ccaaagccaa agaacgccac cgtgctgatc tggatctacg gaggacactt ccagaccgga     4500

accagcagcc tgcacgtgta cgatggaaag ttcctggccc gggtggagcg ggtgatcgtg     4560

gtgagcatga actaccgggt gggagccctg ggattcctgg ccctgccagg aaacccagag     4620

gccccaggaa acatgggact gttcgatcag cagctggccc tgcagtgggt gcagaagaac     4680

atcgccgcct tcggaggaaa cccaaagagc gtgaccctgt tcggacagag cgccggagcc     4740

gccagcgtga gcctgcacct gctgagccca ggaagccaca gcctgttcac ccgggccatc     4800

ctgcagagcg gaagcttcaa cgccccatgg gccgtgacca gcctgtacga ggcccggaac     4860

cggaccctga acctggccaa gctgaccgga tgcagccggg agaacgagac cgagatcatc     4920

aagtgcctgc ggaacaagga tccacaggag atcctgctga acgaggcctt cgtggtgcca     4980

tacggaaccc cactgagcgt gaacttcgga ccaaccgtgg atggagattt cctgaccgat     5040

atgccagata tcctgctgga gctgggacag ttcaagaaga cccagatcct ggtgggagtg     5100

aacaaggatg agggaaccgc cttcctggtg tacggagccc caggattcag caaggataac     5160

aacagcatca tcacccggaa ggagttccag gagggactga agatcttctt cccaggagtg     5220

agcgagttcg gaaaggagag catcctgttc cactacaccg attgggtgga tgatcagcgg     5280

ccagagaact accgggaggc cctgggagat gtggtgggag attacaactt catctgccca     5340

gccctggagt tcaccaagaa gttcagcgag tggggaaaca acgccttctt ctactacttc     5400

gagcaccgga gcagcaagct gccatggcca gagtggatgg gagtgatgca cggatacgag     5460

atcgagttcg tgttcggact gccactggag cggcgggata actacaccaa ggccgaggag     5520

atcctgagcc ggagcatcgt gaagcggtgg gccaacttcg ccaagtacgg aaacccaaac     5580

gagacccaga acaacagcac cagctggcca gtgttcaaga gcaccgagca gaagtacctg     5640

accctgaaca ccgagagcac ccggatcatg accaagctgc gggcccagca gtgccggttc     5700

tggaccagct tcttcccaaa ggtgctggag atgaccggaa acatcgatga ggccgagtgg     5760

gagtggaagg ccggattcca ccggtggaac aactacatga tggattggaa gaaccagttc     5820

aacgattaca ccagcaagaa ggagagctgc gtgggactgt gataaggccg gcccctctcc     5880

ctcccccccc cctaacgtta ctggccgaag ccgcttggaa taaggccggt gtgcgtttgt     5940

ctatatgtta ttttccacca tattgccgtc ttttggcaat gtgagggccc ggaaacctgg     6000

ccctgtcttc ttgacgagca ttcctagggg tctttcccct ctcgccaaag gaatgcaagg     6060

tctgttgaat gtcgtgaagg aagcagttcc tctggaagct tcttgaagac aaacaacgtc     6120

tgtagcgacc ctttgcaggc agcggaaccc cccacctggc gacaggtgcc tctgcggcca     6180

aaagccacgt gtataagata cacctgcaaa ggcggcacaa ccccagtgcc acgttgtgag     6240

ttggatagtt gtggaaagag tcaaatggct ctcctcaagc gtattcaaca aggggctgaa     6300

ggatgcccag aaggtacccc attgtatggg atctgatctg gggcctcggt acacatgctt     6360

tacatgtgtt tagtcgaggt taaaaaaacg tctaggcccc ccgaaccacg gggacgtggt     6420

tttcctttga aaaacacgat gataatatgg ccacaaccat gtaccgcatg caactcctgt     6480

cttgcattgc actaagtctt gcacttgtca caaacagtcc acagaagagc tgcagcaagg     6540

tgaccgatag ctgccggcac gtgtgccagt gccggccacc accaccactg ccaccaccac     6600

caccaccacc accaccacca cggctgctga gcgccccagc cccaaacagc accagctgcc     6660

caaccgagga gagctggtgg agcggatgat gaaagcttgc ggccgcttcg agcagacatg     6720

ataagataca ttgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     6780

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     6840

gttaacaaca acaattgcat tcattttatg tttcaggttc agggggagat gtgggaggtt     6900

ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg ataaggatct tcctagagca     6960

tggctacgta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     7020

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     7080

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           7134


<210>  40
<211>  4358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV.hBChE C2.IRES.PRIMA1


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (191)..(932)
<223>  human CMV IE enhancer/promoer

<220>
<221>  TATA_signal
<222>  (897)..(901)

<220>
<221>  Intron
<222>  (1047)..(1179)
<223>  Promega chimeric intron (PI)

<220>
<221>  misc_feature
<222>  (1293)..(3097)
<223>  BuChE C2

<220>
<221>  misc_feature
<222>  (3095)..(3685)
<223>  IRES

<220>
<221>  misc_feature
<222>  (3690)..(3930)
<223>  PRIMA1 PRP

<220>
<221>  polyA_signal
<222>  (3933)..(4164)
<223>  SV40 polyA

<220>
<221>  misc_feature
<222>  (4229)..(4358)
<223>  3'ITR

<400>  40
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatct tcaatattgg ccattagcca tattattcat tggttatata gcataaatca      240

atattggcta ttggccattg catacgttgt atctatatca taatatgtac atttatattg      300

gctcatgtcc aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat      360

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg      420

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt      480

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac      540

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg      600

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact      660

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt      720

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc      780

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc      840

gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata      900

taagcagagc tcgtttagtg aaccgtcaga tcactagaag ctttattgcg gtagtttatc      960

acagttaaat tgctaacgca gtcagtgctt ctgacacaac agtctcgaac ttaagctgca     1020

gaagttggtc gtgaggcact gggcaggtaa gtatcaaggt tacaagacag gtttaaggag     1080

accaatagaa actgggcttg tcgagacaga gaagactctt gcgtttctga taggcaccta     1140

ttggtcttac tgacatccac tttgcctttc tctccacagg tgtccactcc cagttcaatt     1200

acagctctta aggctagagt acttaatacg actcactata ggctagcggg gactttgcac     1260

tggaacttac aacacccgag caaggacgcg actctagacc caccatgaga atgcaattgt     1320

tgttgttgat tgcattgtca ttggcattgg tgacaaattc agaagatgat attattattg     1380

caacaaaaaa tggtaaagtg agaggtatga atttgacagt gtttggtggt acagtgacag     1440

catttttggg tattccatat gcacaaccac cattgggtag attgagattt aaaaaaccac     1500

aatcattgac aaaatggtca gatatttgga atgcaacaaa atatgcaaat tcatgttgtc     1560

aaaatattga tcaatcattt ccaggttttc atggttcaga aatgtggaat ccaaatacag     1620

atttgtcaga agattgtttg tatttgaatg tgtggattcc agcaccaaaa ccaaaaaatg     1680

caacagtgtt gatttggatt tatggtggtg gttttcaaac aggtacatca tcattgcatg     1740

tgtatgatgg taaatttttg gcaagagtgg aaagagtgat tgtggtgtca atgaattata     1800

gagtgggtgc attgggtttt ttggcattgc caggtaatcc agaagcacca ggtaatatgg     1860

gtttgtttga tcaacaattg gcattgcaat gggtgcaaaa aaatattgca gcatttggtg     1920

gtaatccaaa atcagtgaca ttgtttggtg aatcagcagg tgcagcatca gtgtcattgc     1980

atttgttgtc accaggttca cattcattgt ttacaagagc aattttgcaa tcaggttcat     2040

ttaatgcacc atgggcagtg acatcattgt atgaagcaag aaatagaaca ttgaatttgg     2100

caaaattgac aggttgttca agagaaaatg aaacagaaat tattaaatgt ttgagaaata     2160

aagatccaca agaaattttg ttgaatgaag catttgtggt gccatatggt acaccattgt     2220

cagtgaattt tggtccaaca gtggatggtg attttttgac agatatgcca gatattttgt     2280

tggaattggg tcaatttaaa aaaacacaaa ttttggtggg tgtgaataaa gatgaaggta     2340

cagcattttt ggtgtatggt gcaccaggtt tttcaaaaga taataattca attattacaa     2400

gaaaagaatt tcaagaaggt ttgaaaattt tttttccagg tgtgtcagaa tttggtaaag     2460

aatcaatttt gtttcattat acagattggg tggatgatca aagaccagaa aattatagag     2520

aagcattggg tgatgtggtg ggtgattata attttatttg tccagcattg gaatttacaa     2580

aaaaattttc agaatggggt aataatgcat ttttttatta ttttgaacat agatcatcaa     2640

aattgccatg gccagaatgg atgggtgtga tgcatggtta tgaaattgaa tttgtgtttg     2700

gtttgccatt ggaaagaaga gataattata caaaagcaga agaaattttg tcaagatcaa     2760

ttgtgaaaag atgggcaaat tttgcaaaat atggtaatcc aaatgaaaca caaaataatt     2820

caacatcatg gccagtgttt aaatcaacag aacaaaaata tttgacattg aatacagaat     2880

caacaagaat tatgacaaaa ttgagagcac aacaatgtag attttggaca tcattttttc     2940

caaaagtgtt ggaaatgaca ggtaatattg atgaagcaga atgggaatgg aaagcaggtt     3000

ttcatagatg gaataattat atgatggatt ggaaaaatca atttaatgat tatacatcaa     3060

aaaaagaatc atgtgtgggt ttgtgataag gccggcccct ctccctcccc cccccctaac     3120

gttactggcc gaagccgctt ggaataaggc cggtgtgcgt ttgtctatat gttattttcc     3180

accatattgc cgtcttttgg caatgtgagg gcccggaaac ctggccctgt cttcttgacg     3240

agcattccta ggggtctttc ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg     3300

aaggaagcag ttcctctgga agcttcttga agacaaacaa cgtctgtagc gaccctttgc     3360

aggcagcgga accccccacc tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa     3420

gatacacctg caaaggcggc acaaccccag tgccacgttg tgagttggat agttgtggaa     3480

agagtcaaat ggctctcctc aagcgtattc aacaaggggc tgaaggatgc ccagaaggta     3540

ccccattgta tgggatctga tctggggcct cggtacacat gctttacatg tgtttagtcg     3600

aggttaaaaa aacgtctagg ccccccgaac cacggggacg tggttttcct ttgaaaaaca     3660

cgatgataat atggccacaa ccatgtaccg catgcaactc ctgtcttgca ttgcactaag     3720

tcttgcactt gtcacaaaca gtccacagaa gagctgcagc aaggtgaccg atagctgccg     3780

gcacgtgtgc cagtgccggc caccaccacc actgccacca ccaccaccac caccaccacc     3840

accacggctg ctgagcgccc cagccccaaa cagcaccagc tgcccaaccg aggagagctg     3900

gtggagcgga tgatgaaagc ttgcggccgc ttcgagcaga catgataaga tacattgatg     3960

agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg     4020

atgctattgc tttatttgta accattataa gctgcaataa acaagttaac aacaacaatt     4080

gcattcattt tatgtttcag gttcaggggg agatgtggga ggttttttaa agcaagtaaa     4140

acctctacaa atgtggtaaa atcgataagg atcttcctag agcatggcta cgtagataag     4200

tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc     4260

tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc     4320

tttgcccggg cggcctcagt gagcgagcga gcgcgcag                             4358


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Proline-rich peptide domain

<400>  41

Pro Ser Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
            20                  25          


<210>  42
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Asp Leu Thr Gln Val Met Asp Asp Glu Val Phe Met Ala Phe 
1               5                   10                  15      


Ala Ser Tyr Ala Thr Ile Ile Leu Ser Lys Met Met Leu Met Ser Thr 
            20                  25                  30          


Ala Thr Ala Phe Tyr Arg Leu Thr Arg Lys Val Phe Ala Asn Pro Glu 
        35                  40                  45              


Asp Cys Val Phe Gly Lys Gly Glu Asn Ala Lys Lys Tyr Leu Arg Thr 
    50                  55                  60                  


Asp Asp Arg Val Glu Arg Val Arg Arg Ala His Leu Asn Asp Leu Glu 
65                  70                  75                  80  


Asn Ile Ile Pro Phe Leu Gly Ile Gly Leu Leu Tyr Ser Leu Ser Gly 
                85                  90                  95      


Pro Asp Pro Ser Thr Ala Ile Leu His Phe Arg Leu Phe Val Gly Ala 
            100                 105                 110         


Arg Ile Tyr His Thr Ile Ala Tyr Leu Thr Pro Leu Pro Gln Pro Asn 
        115                 120                 125             


Arg Ala Leu Ser Phe Phe Val Gly Tyr Gly Val Thr Ser Met Ala Tyr 
    130                 135                 140                 


Arg Leu Leu Lys Ser Lys Leu Tyr Leu 
145                 150             


<210>  43
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Glu Lys Pro Lys Leu His Tyr Phe Asn Ala Arg Gly Arg Met 
1               5                   10                  15      


Glu Ser Thr Arg Trp Leu Leu Ala Ala Ala Gly Val Glu Phe Glu Glu 
            20                  25                  30          


Lys Phe Ile Lys Ser Ala Glu Asp Leu Asp Lys Leu Arg Asn Asp Gly 
        35                  40                  45              


Tyr Leu Met Phe Gln Gln Val Pro Met Val Glu Ile Asp Gly Met Lys 
    50                  55                  60                  


Leu Val Gln Thr Arg Ala Ile Leu Asn Tyr Ile Ala Ser Lys Tyr Asn 
65                  70                  75                  80  


Leu Tyr Gly Lys Asp Ile Lys Glu Arg Ala Leu Ile Asp Met Tyr Ile 
                85                  90                  95      


Glu Gly Ile Ala Asp Leu Gly Glu Met Ile Leu Leu Leu Pro Val Cys 
            100                 105                 110         


Pro Pro Glu Glu Lys Asp Ala Lys Leu Ala Leu Ile Lys Glu Lys Ile 
        115                 120                 125             


Lys Asn Arg Tyr Phe Pro Ala Phe Glu Lys Val Leu Lys Ser His Gly 
    130                 135                 140                 


Gln Asp Tyr Leu Val Gly Asn Lys Leu Ser Arg Ala Asp Ile His Leu 
145                 150                 155                 160 


Val Glu Leu Leu Tyr Tyr Val Glu Glu Leu Asp Ser Ser Leu Ile Ser 
                165                 170                 175     


Ser Phe Pro Leu Leu Lys Ala Leu Lys Thr Arg Ile Ser Asn Leu Pro 
            180                 185                 190         


Thr Val Lys Lys Phe Leu Gln Pro Gly Ser Pro Arg Lys Pro Pro Met 
        195                 200                 205             


Asp Glu Lys Ser Leu Glu Glu Ala Arg Lys Ile Phe Arg Phe 
    210                 215                 220         


<210>  44
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Val His Gln Val Leu Tyr Arg Ala Leu Val Ser Thr Lys Trp Leu 
1               5                   10                  15      


Ala Glu Ser Ile Arg Thr Gly Lys Leu Gly Pro Gly Leu Arg Val Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Ser Pro Gly Thr Arg Glu Ala Arg Lys Glu Tyr 
        35                  40                  45              


Leu Glu Arg His Val Pro Gly Ala Ser Phe Phe Asp Ile Glu Glu Cys 
    50                  55                  60                  


Arg Asp Thr Ala Ser Pro Tyr Glu Met Met Leu Pro Ser Glu Ala Gly 
65                  70                  75                  80  


Phe Ala Glu Tyr Val Gly Arg Leu Gly Ile Ser Asn His Thr His Val 
                85                  90                  95      


Val Val Tyr Asp Gly Glu His Leu Gly Ser Phe Tyr Ala Pro Arg Val 
            100                 105                 110         


Trp Trp Met Phe Arg Val Phe Gly His Arg Thr Val Ser Val Leu Asn 
        115                 120                 125             


Gly Gly Phe Arg Asn Trp Leu Lys Glu Gly His Pro Val Thr Ser Glu 
    130                 135                 140                 


Pro Ser Arg Pro Glu Pro Ala Val Phe Lys Ala Thr Leu Asp Arg Ser 
145                 150                 155                 160 


Leu Leu Lys Thr Tyr Glu Gln Val Leu Glu Asn Leu Glu Ser Lys Arg 
                165                 170                 175     


Phe Gln Leu Val Asp Ser Arg Ser Gln Gly Arg Phe Leu Gly Thr Glu 
            180                 185                 190         


Pro Glu Pro Asp Ala Val Gly Leu Asp Ser Gly His Ile Arg Gly Ala 
        195                 200                 205             


Val Asn Met Pro Phe Met Asp Phe Leu Thr Glu Asp Gly Phe Glu Lys 
    210                 215                 220                 


Gly Pro Glu Glu Leu Arg Ala Leu Phe Gln Thr Lys Lys Val Asp Leu 
225                 230                 235                 240 


Ser Gln Pro Leu Ile Ala Thr Cys Arg Lys Gly Val Thr Ala Cys His 
                245                 250                 255     


Val Ala Leu Ala Ala Tyr Leu Cys Gly Lys Pro Asp Val Ala Val Tyr 
            260                 265                 270         


Asp Gly Ser Trp Ser Glu Trp Phe Arg Arg Ala Pro Pro Glu Ser Arg 
        275                 280                 285             


Val Ser Gln Gly Lys Ser Glu Lys Ala 
    290                 295         


<210>  45
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala Gln Trp Val 
1               5                   10                  15      


Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu Gln Leu Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala Arg Arg Glu 
        35                  40                  45              


Phe Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp Ile Asp Gln 
    50                  55                  60                  


Cys Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro Gly Ala Glu 
65                  70                  75                  80  


His Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala Ala Thr His 
                85                  90                  95      


Val Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser Ala Pro Arg 
            100                 105                 110         


Val Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val Ser Leu Leu 
        115                 120                 125             


Asp Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro Leu Ser Ser 
    130                 135                 140                 


Gly Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln Leu Asp Pro 
145                 150                 155                 160 


Ala Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu Glu Ser Arg 
                165                 170                 175     


Arg Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe Arg Gly Thr 
            180                 185                 190         


Glu Pro Glu Pro Arg Asp Gly Ile Glu Pro Gly His Ile Pro Gly Thr 
        195                 200                 205             


Val Asn Ile Pro Phe Thr Asp Phe Leu Ser Gln Glu Gly Leu Glu Lys 
    210                 215                 220                 


Ser Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys Val Asp Leu 
225                 230                 235                 240 


Ser Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr Ala Cys His 
                245                 250                 255     


Val Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val Pro Ile Tyr 
            260                 265                 270         


Asp Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro Glu Asp Val 
        275                 280                 285             


Ile Ser Glu Gly Arg Gly Lys Thr His 
    290                 295         


<210>  46
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Ser Pro Gln Leu Cys Arg Ala Leu Val Ser Ala Gln Trp Val 
1               5                   10                  15      


Ala Glu Ala Leu Arg Ala Pro Arg Ala Gly Gln Pro Leu Gln Leu Leu 
            20                  25                  30          


Asp Ala Ser Trp Tyr Leu Pro Lys Leu Gly Arg Asp Ala Thr Gln Phe 
        35                  40                  45              


Glu Glu Arg His Ile Pro Gly Ala Ala Phe Phe Asp Ile Asp Gln Cys 
    50                  55                  60                  


Ser Asp Arg Thr Ser Pro Tyr Asp His Met Leu Pro Gly Ala Glu His 
65                  70                  75                  80  


Phe Ala Glu Tyr Ala Gly Arg Leu Gly Val Gly Ala Ala Thr His Val 
                85                  90                  95      


Val Ile Tyr Asp Ala Ser Asp Gln Gly Leu Tyr Ser Ala Pro Arg Val 
            100                 105                 110         


Trp Trp Met Phe Arg Ala Phe Gly His His Ala Val Ser Leu Leu Asp 
        115                 120                 125             


Gly Gly Leu Arg His Trp Leu Arg Gln Asn Leu Pro Leu Ser Ser Gly 
    130                 135                 140                 


Lys Ser Gln Pro Ala Pro Ala Glu Phe Arg Ala Gln Leu Asp Pro Ala 
145                 150                 155                 160 


Phe Ile Lys Thr Tyr Glu Asp Ile Lys Glu Asn Leu Glu Ser Arg Arg 
                165                 170                 175     


Phe Gln Val Val Asp Ser Arg Ala Thr Gly Arg Phe Arg Gly Thr Glu 
            180                 185                 190         


Pro Glu Pro Arg Asp Gly Ile Glu Pro Gly His Ile Pro Gly Thr Val 
        195                 200                 205             


Asn Ile Pro Phe Thr Asp Phe Leu Ser Gln Glu Gly Leu Glu Lys Ser 
    210                 215                 220                 


Pro Glu Glu Ile Arg His Leu Phe Gln Glu Lys Lys Val Asp Leu Ser 
225                 230                 235                 240 


Lys Pro Leu Val Ala Thr Cys Gly Ser Gly Val Thr Ala Cys His Val 
                245                 250                 255     


Ala Leu Gly Ala Tyr Leu Cys Gly Lys Pro Asp Val Pro Ile Tyr Asp 
            260                 265                 270         


Gly Ser Trp Val Glu Trp Tyr Met Arg Ala Arg Pro Glu Asp Val Ile 
        275                 280                 285             


Ser Glu Gly Arg Gly Lys Thr His 
    290                 295     


<210>  47
<211>  738
<212>  PRT
<213>  Unknown

<220>
<223>  AAV8 capsid

<400>  47

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  48
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Gln Lys Ser Cys Ser Lys Val Thr Asp Ser Cys Arg His Val Cys 
1               5                   10                  15      


Gln Cys Arg Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Arg Leu Leu 
            20                  25                  30          


Ser Ala Pro Ala Pro Asn Ser Thr Ser Cys Pro Thr Glu Glu Ser Trp 
        35                  40                  45              


Trp Ser Gly 
    50      


<210>  49
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Pro Gln Pro Lys Ile Val Thr Pro Tyr Thr Ala Ser Gln Pro Ser 
1               5                   10                  15      


Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Pro Pro Leu Pro Ser Gln Ser Ala Pro Ser Ala 
        35                  40                  45              


Gly Ser Ala Ala Pro Met Phe Val Lys Tyr Ser Thr Ile Thr Arg Leu 
    50                  55                  60                  


Gln Asn Ala Ser Gln His Ser Gly 
65                  70          


<210>  50
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7 promoter

<400>  50
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa g              1731


<210>  51
<211>  4852
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C4/UbC.hIL2.BChE C1.IRES.PRIMA.RBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  enhancer
<222>  (279)..(538)
<223>  C4 enhancer with 2 mismatches

<220>
<221>  promoter
<222>  (565)..(1793)
<223>  UbC promoter

<220>
<221>  misc_feature
<222>  (1828)..(3626)
<223>  BChE C1 with human IL2 leader

<220>
<221>  misc_feature
<222>  (1837)..(1893)
<223>  human IL2 leader

<220>
<221>  misc_feature
<222>  (3627)..(4217)
<223>  IRES

<220>
<221>  misc_feature
<222>  (4222)..(4447)
<223>  PRIMA1

<220>
<221>  polyA_signal
<222>  (4508)..(4634)
<223>  Rabbit beta globin polyA

<220>
<221>  repeat_region
<222>  (4723)..(4852)

<400>  51
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg atctggcctc cgcgccgggt tttggcgcct cccgcgggcg      600

cccccctcct cacggcgagc gctgccacgt cagacgaagg gcgcagcgag cgtcctgatc      660

cttccgcccg gacgctcagg acagcggccc gctgctcata agactcggcc ttagaacccc      720

agtatcagca gaaggacatt ttaggacggg acttgggtga ctctagggca ctggttttct      780

ttccagagag cggaacaggc gaggaaaagt agtcccttct cggcgattct gcggagggat      840

ctccgtgggg cggtgaacgc cgatgattat ataaggacgc gccgggtgtg gcacagctag      900

ttccgtcgca gccgggattt gggtcgcggt tcttgtttgt ggatcgctgt gatcgtcact      960

tggtgagtag cgggctgctg ggctggccgg ggctttcgtg gccgccgggc cgctcggtgg     1020

gacggaagcg tgtggagaga ccgccaaggg ctgtagtctg ggtccgcgag caaggttgcc     1080

ctgaactggg ggttgggggg agcgcagcaa aatggcggct gttcccgagt cttgaatgga     1140

agacgcttgt gaggcgggct gtgaggtcgt tgaaacaagg tggggggcat ggtgggcggc     1200

aagaacccaa ggtcttgagg ccttcgctaa tgcgggaaag ctcttattcg ggtgagatgg     1260

gctggggcac catctgggga ccctgacgtg aagtttgtca ctgactggag aactcggttt     1320

gtcgtctgtt gcgggggcgg cagttatggc ggtgccgttg ggcagtgcac ccgtaccttt     1380

gggagcgcgc gccctcgtcg tgtcgtgacg tcacccgttc tgttggctta taatgcaggg     1440

tggggccacc tgccggtagg tgtgcggtag gcttttctcc gtcgcaggac gcagggttcg     1500

ggcctagggt aggctctcct gaatcgacag gcgccggacc tctggtgagg ggagggataa     1560

gtgaggcgtc agtttctttg gtcggtttta tgtacctatc ttcttaagta gctgaagctc     1620

cggttttgaa ctatgcgctc ggggttggcg agtgtgtttt gtgaagtttt ttaggcacct     1680

tttgaaatgt aatcatttgg gtcaatatgt aattttcagt gttagactag taaattgtcc     1740

gctaaattct ggccgttttt ggcttttttg ttagacgaag cttggtaccg agctcggatc     1800

cactagtcca gtgtggtgga attcgctaga cccaccatgc ggatgcagct gctgctgctg     1860

attgctctga gcctggctct ggtgaccaac agcgaagacg acattattat tgctaccaag     1920

aacggcaagg tgcggggcat gaacctgacc gtgtttggcg gcaccgtgac cgcttttctg     1980

ggcattccct atgctcagcc ccccctgggc cggctgcggt ttaagaagcc ccagagcctg     2040

accaagtgga gcgacatttg gaacgctacc aagtatgcta acagctgttg tcagaacatt     2100

gaccagagct ttcccggctt tcatggcagc gaaatgtgga accccaacac cgacctgagc     2160

gaagactgtc tgtatctgaa cgtgtggatt cccgctccca agcccaagaa cgctaccgtg     2220

ctgatttgga tttatggcgg cggctttcag accggcacca gcagcctgca tgtgtatgac     2280

ggcaagtttc tggctcgggt ggaacgggtg attgtggtga gcatgaacta tcgggtgggc     2340

gctctgggct ttctggctct gcccggcaac cccgaagctc ccggcaacat gggcctgttt     2400

gaccagcagc tggctctgca gtgggtgcag aagaacattg ctgcttttgg cggcaacccc     2460

aagagcgtga ccctgtttgg cgaaagcgct ggcgctgcta gcgtgagcct gcatctgctg     2520

agccccggca gccatagcct gtttacccgg gctattctgc agagcggcag ctttaacgct     2580

ccctgggctg tgaccagcct gtatgaagct cggaaccgga ccctgaacct ggctaagctg     2640

accggctgta gccgggaaaa cgaaaccgaa attattaagt gtctgcggaa caaggacccc     2700

caggaaattc tgctgaacga agcttttgtg gtgccctatg gcacccccct gagcgtgaac     2760

tttggcccca ccgtggacgg cgactttctg accgacatgc ccgacattct gctggaactg     2820

ggccagttta agaagaccca gattctggtg ggcgtgaaca aggacgaagg caccgctttt     2880

ctggtgtatg gcgctcccgg ctttagcaag gacaacaaca gcattattac ccggaaggaa     2940

tttcaggaag gcctgaagat tttttttccc ggcgtgagcg aatttggcaa ggaaagcatt     3000

ctgtttcatt ataccgactg ggtggacgac cagcggcccg aaaactatcg ggaagctctg     3060

ggcgacgtgg tgggcgacta taactttatt tgtcccgctc tggaatttac caagaagttt     3120

agcgaatggg gcaacaacgc ttttttttat tattttgaac atcggagcag caagctgccc     3180

tggcccgaat ggatgggcgt gatgcatggc tatgaaattg aatttgtgtt tggcctgccc     3240

ctggaacggc gggacaacta taccaaggct gaagaaattc tgagccggag cattgtgaag     3300

cggtgggcta actttgctaa gtatggcaac cccaacgaaa cccagaacaa cagcaccagc     3360

tggcccgtgt ttaagagcac cgaacagaag tatctgaccc tgaacaccga aagcacccgg     3420

attatgacca agctgcgggc tcagcagtgt cggttttgga ccagcttttt tcccaaggtg     3480

ctggaaatga ccggcaacat tgacgaagct gaatgggaat ggaaggctgg ctttcatcgg     3540

tggaacaact atatgatgga ctggaagaac cagtttaacg actataccag caagaaggaa     3600

agctgtgtgg gcctgtgata aggccggccc ctctccctcc ccccccccta acgttactgg     3660

ccgaagccgc ttggaataag gccggtgtgc gtttgtctat atgttatttt ccaccatatt     3720

gccgtctttt ggcaatgtga gggcccggaa acctggccct gtcttcttga cgagcattcc     3780

taggggtctt tcccctctcg ccaaaggaat gcaaggtctg ttgaatgtcg tgaaggaagc     3840

agttcctctg gaagcttctt gaagacaaac aacgtctgta gcgacccttt gcaggcagcg     3900

gaacccccca cctggcgaca ggtgcctctg cggccaaaag ccacgtgtat aagatacacc     3960

tgcaaaggcg gcacaacccc agtgccacgt tgtgagttgg atagttgtgg aaagagtcaa     4020

atggctctcc tcaagcgtat tcaacaaggg gctgaaggat gcccagaagg taccccattg     4080

tatgggatct gatctggggc ctcggtacac atgctttaca tgtgtttagt cgaggttaaa     4140

aaaacgtcta ggccccccga accacgggga cgtggttttc ctttgaaaaa cacgatgata     4200

atatggccac aaccatgtac cgcatgcaac tcctgtcttg cattgcacta agtcttgcac     4260

ttgtcacaaa cagtccacag aagagctgca gcaaggtgac cgatagctgc cggcacgtgt     4320

gccagtgccg gccaccacca ccactgccac caccaccacc acggctgctg agcgccccag     4380

ccccaaacag caccagctgc ccaaccgagg agagctggtg gagcggatga tgaaagcttg     4440

cggccgcggt acctctagag tcgacccggg cggcctcgag gacggggtga actacgcctg     4500

aggatccgat ctttttccct ctgccaaaaa ttatggggac atcatgaagc cccttgagca     4560

tctgacttct ggctaataaa ggaaatttat tttcattgca atagtgtgtt ggaatttttt     4620

gtgtctctca ctcggaagca attcgttgat ctgaatttcg accacccata atacccatta     4680

ccctggtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg     4740

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     4800

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             4852


