                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Inc.
 
<120>  STABLE POLIOVIRUS VARIANTS AND USES THEREOF

<130>  U1197.70089WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/324,252
<151>  2016-04-18

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  340
<212>  PRT
<213>  Poliovirus Serotype 1 VP0

<400>  1

Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser Asn 
1               5                   10                  15      


Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr Tyr 
            20                  25                  30          


Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln Asp 
        35                  40                  45              


Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr Ala 
    50                  55                  60                  


Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg 
65                  70                  75                  80  


Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala 
                85                  90                  95      


Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg Asp 
            100                 105                 110         


Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala 
        115                 120                 125             


Cys Arg Phe Tyr Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser Arg 
    130                 135                 140                 


Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu Phe 
145                 150                 155                 160 


Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr Val 
                165                 170                 175     


His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val 
            180                 185                 190         


Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr Thr 
        195                 200                 205             


Met His Thr Ser Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly Thr 
    210                 215                 220                 


Phe Thr Gly Thr Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala Arg 
225                 230                 235                 240 


Arg Phe Cys Pro Val Asp Tyr Leu Leu Gly Asn Gly Thr Leu Leu Gly 
                245                 250                 255     


Asn Ala Phe Val Phe Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser 
        275                 280                 285             


Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro 
    290                 295                 300                 


Leu Asn Phe Ala Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Leu 
                325                 330                 335     


Pro Arg Leu Gln 
            340 


<210>  2
<211>  68
<212>  PRT
<213>  Poliovirus Serotype 1 VP4

<400>  2

Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser Asn 
1               5                   10                  15      


Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr Tyr 
            20                  25                  30          


Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln Asp 
        35                  40                  45              


Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr Ala 
    50                  55                  60                  


Pro Met Leu Asn 
65              


<210>  3
<211>  272
<212>  PRT
<213>  Poliovirus Serotype 1 VP2

<400>  3

Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg Val Leu Gln Leu 
1               5                   10                  15      


Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala Ala Asn Ser Val 
            20                  25                  30          


Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg Asp Ser Glu Ala Asn 
        35                  40                  45              


Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala Cys Arg Phe Tyr 
    50                  55                  60                  


Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser Arg Gly Trp Trp Trp 
65                  70                  75                  80  


Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu Phe Gly Gln Asn Met 
                85                  90                  95      


Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr Val His Val Gln Cys 
            100                 105                 110         


Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val Phe Ala Val Pro 
        115                 120                 125             


Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr Thr Met His Thr Ser 
    130                 135                 140                 


Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly Thr Phe Thr Gly Thr 
145                 150                 155                 160 


Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala Arg Arg Phe Cys Pro 
                165                 170                 175     


Val Asp Tyr Leu Leu Gly Asn Gly Thr Leu Leu Gly Asn Ala Phe Val 
            180                 185                 190         


Phe Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn Cys Ala Thr Leu 
        195                 200                 205             


Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser Met Val Lys His 
    210                 215                 220                 


Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro Leu Asn Phe Ala 
225                 230                 235                 240 


Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu Thr Ile Ala Pro Met 
                245                 250                 255     


Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Leu Pro Arg Leu Gln 
            260                 265                 270         


<210>  4
<211>  238
<212>  PRT
<213>  Poliovirus Serotype 1 VP3

<400>  4

Gly Leu Pro Val Met Asn Thr Pro Gly Ser Asn Gln Tyr Leu Thr Ala 
1               5                   10                  15      


Asp Asn Phe Gln Ser Pro Cys Ala Leu Pro Glu Phe Asp Val Thr Pro 
            20                  25                  30          


Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met Glu Leu Ala Glu 
        35                  40                  45              


Ile Asp Thr Met Ile Pro Phe Asp Leu Ser Ala Thr Lys Lys Asn Thr 
    50                  55                  60                  


Met Glu Met Tyr Arg Val Arg Leu Ser Asp Lys Pro His Thr Asp Asp 
65                  70                  75                  80  


Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp Pro Arg Leu Ser 
                85                  90                  95      


His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr His Trp Ala Gly 
            100                 105                 110         


Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Phe Met Met Ala Thr Gly 
        115                 120                 125             


Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Asp Pro Pro Lys Lys 
    130                 135                 140                 


Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp Asp Ile Gly Leu 
145                 150                 155                 160 


Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser Asn Thr Thr Tyr 
                165                 170                 175     


Arg Gln Thr Ile Asp Asp Ser Phe Thr Glu Gly Gly Tyr Ile Ser Val 
            180                 185                 190         


Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr Pro Arg Glu Met 
        195                 200                 205             


Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Leu 
    210                 215                 220                 


Leu Arg Asp Thr Thr His Ile Glu Gln Lys Ala Leu Ala Gln 
225                 230                 235             


<210>  5
<211>  302
<212>  PRT
<213>  Poliovirus Serotype 1 VP1

<400>  5

Gly Leu Gly Gln Met Leu Glu Ser Met Ile Asp Asn Thr Val Arg Glu 
1               5                   10                  15      


Thr Val Gly Ala Ala Thr Ser Arg Asp Ala Leu Pro Asn Thr Glu Ala 
            20                  25                  30          


Ser Gly Pro Thr His Ser Lys Glu Ile Pro Ala Leu Thr Ala Val Glu 
        35                  40                  45              


Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln Thr Arg 
    50                  55                  60                  


His Val Val Gln His Arg Ser Arg Ser Glu Ser Ser Ile Glu Ser Phe 
65                  70                  75                  80  


Phe Ala Arg Gly Ala Cys Val Thr Ile Met Thr Val Asp Asn Pro Ala 
                85                  90                  95      


Ser Thr Thr Asn Lys Asp Lys Leu Phe Ala Val Trp Lys Ile Thr Tyr 
            100                 105                 110         


Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr Tyr Ser 
        115                 120                 125             


Arg Phe Asp Met Glu Leu Thr Phe Val Val Thr Ala Asn Phe Thr Glu 
    130                 135                 140                 


Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met Tyr Val 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Val Pro Glu Lys Trp Asp Asp Tyr Thr Trp Gln 
                165                 170                 175     


Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Thr Ala Pro Ala 
            180                 185                 190         


Arg Ile Ser Val Pro Tyr Val Gly Ile Ser Asn Ala Tyr Ser His Phe 
        195                 200                 205             


Tyr Asp Gly Phe Ser Lys Val Pro Leu Lys Asp Gln Ser Ala Ala Leu 
    210                 215                 220                 


Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly Ile Leu 
225                 230                 235                 240 


Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr Ser Lys 
                245                 250                 255     


Ile Arg Val Tyr Leu Lys Pro Lys His Ile Arg Val Trp Cys Pro Arg 
            260                 265                 270         


Pro Pro Arg Ala Val Ala Tyr Tyr Gly Pro Gly Val Asp Tyr Lys Asp 
        275                 280                 285             


Gly Thr Leu Thr Pro Leu Ser Thr Lys Asp Leu Thr Thr Tyr 
    290                 295                 300         


<210>  6
<211>  644
<212>  PRT
<213>  Poliovirus Serotype 1 3CD

<400>  6

Gly Pro Gly Phe Asp Tyr Ala Val Ala Met Ala Lys Arg Asn Ile Val 
1               5                   10                  15      


Thr Ala Thr Thr Ser Lys Gly Glu Phe Thr Met Leu Gly Val His Asp 
            20                  25                  30          


Asn Val Ala Ile Leu Pro Thr His Ala Ser Pro Gly Glu Ser Ile Val 
        35                  40                  45              


Ile Asp Gly Lys Glu Val Glu Ile Leu Asp Ala Lys Ala Leu Glu Asp 
    50                  55                  60                  


Gln Ala Gly Thr Asn Leu Glu Ile Thr Ile Ile Thr Leu Lys Arg Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asp Ile Arg Pro His Ile Pro Thr Gln Ile Thr Glu 
                85                  90                  95      


Thr Asn Asp Gly Val Leu Ile Val Asn Thr Ser Lys Tyr Pro Asn Met 
            100                 105                 110         


Tyr Val Pro Val Gly Ala Val Thr Glu Gln Gly Tyr Leu Asn Leu Gly 
        115                 120                 125             


Gly Arg Gln Thr Ala Arg Thr Leu Met Tyr Asn Phe Pro Thr Arg Ala 
    130                 135                 140                 


Gly Gln Cys Gly Gly Val Ile Thr Cys Thr Gly Lys Val Ile Gly Met 
145                 150                 155                 160 


His Val Gly Gly Asn Gly Ser His Gly Phe Ala Ala Ala Leu Lys Arg 
                165                 170                 175     


Ser Tyr Phe Thr Gln Ser Gln Gly Glu Ile Gln Trp Met Arg Pro Ser 
            180                 185                 190         


Lys Glu Val Gly Tyr Pro Ile Ile Asn Ala Pro Ser Lys Thr Lys Leu 
        195                 200                 205             


Glu Pro Ser Ala Phe His Tyr Val Phe Glu Gly Val Lys Glu Pro Ala 
    210                 215                 220                 


Val Leu Thr Lys Asn Asp Pro Arg Leu Lys Thr Asp Phe Glu Glu Ala 
225                 230                 235                 240 


Ile Phe Ser Lys Tyr Val Gly Asn Lys Ile Thr Glu Val Asp Glu Tyr 
                245                 250                 255     


Met Lys Glu Ala Val Asp His Tyr Ala Gly Gln Leu Met Ser Leu Asp 
            260                 265                 270         


Ile Asn Thr Glu Gln Met Cys Leu Glu Asp Ala Met Tyr Gly Thr Asp 
        275                 280                 285             


Gly Leu Glu Ala Leu Asp Leu Ser Thr Ser Ala Gly Tyr Pro Tyr Val 
    290                 295                 300                 


Ala Met Gly Lys Lys Lys Arg Asp Ile Leu Asn Lys Gln Thr Arg Asp 
305                 310                 315                 320 


Thr Lys Glu Met Gln Lys Leu Leu Asp Thr Tyr Gly Ile Asn Leu Pro 
                325                 330                 335     


Leu Val Thr Tyr Val Lys Asp Glu Leu Arg Ser Lys Thr Lys Val Glu 
            340                 345                 350         


Gln Gly Lys Ser Arg Leu Ile Glu Ala Ser Ser Leu Asn Asp Ser Val 
        355                 360                 365             


Ala Met Arg Met Ala Phe Gly Asn Leu Tyr Ala Ala Phe His Lys Asn 
    370                 375                 380                 


Pro Gly Val Ile Thr Gly Ser Ala Val Gly Cys Asp Pro Asp Leu Phe 
385                 390                 395                 400 


Trp Ser Lys Ile Pro Val Leu Met Glu Glu Lys Leu Phe Ala Phe Asp 
                405                 410                 415     


Tyr Thr Gly Tyr Asp Ala Ser Leu Ser Pro Ala Trp Phe Glu Ala Leu 
            420                 425                 430         


Lys Met Val Leu Glu Lys Ile Gly Phe Gly Asp Arg Val Asp Tyr Ile 
        435                 440                 445             


Asp Tyr Leu Asn His Ser His His Leu Tyr Lys Asn Lys Thr Tyr Cys 
    450                 455                 460                 


Val Lys Gly Gly Met Pro Ser Gly Cys Ser Gly Thr Ser Ile Phe Asn 
465                 470                 475                 480 


Ser Met Ile Asn Asn Leu Ile Ile Arg Thr Leu Leu Leu Lys Thr Tyr 
                485                 490                 495     


Lys Gly Ile Asp Leu Asp His Leu Lys Met Ile Ala Tyr Gly Asp Asp 
            500                 505                 510         


Val Ile Ala Ser Tyr Pro His Glu Val Asp Ala Ser Leu Leu Ala Gln 
        515                 520                 525             


Ser Gly Lys Asp Tyr Gly Leu Thr Met Thr Pro Ala Asp Lys Ser Ala 
    530                 535                 540                 


Thr Phe Glu Thr Val Thr Trp Glu Asn Val Thr Phe Leu Lys Arg Phe 
545                 550                 555                 560 


Phe Arg Ala Asp Glu Lys Tyr Pro Phe Leu Ile His Pro Val Met Pro 
                565                 570                 575     


Met Lys Glu Ile His Glu Ser Ile Arg Trp Thr Lys Asp Pro Arg Asn 
            580                 585                 590         


Thr Gln Asp His Val Arg Ser Leu Cys Leu Leu Ala Trp His Asn Gly 
        595                 600                 605             


Glu Glu Glu Tyr Asn Lys Phe Leu Ala Lys Ile Arg Ser Val Pro Ile 
    610                 615                 620                 


Gly Arg Ala Leu Leu Leu Pro Glu Tyr Ser Thr Leu Tyr Arg Arg Trp 
625                 630                 635                 640 


Leu Asp Ser Phe 
                


<210>  7
<211>  182
<212>  PRT
<213>  Poliovirus Serotype 1 3C

<400>  7

Gly Pro Gly Phe Asp Tyr Ala Val Ala Met Ala Lys Arg Asn Ile Val 
1               5                   10                  15      


Thr Ala Thr Thr Ser Lys Gly Glu Phe Thr Met Leu Gly Val His Asp 
            20                  25                  30          


Asn Val Ala Ile Leu Pro Thr His Ala Ser Pro Gly Glu Ser Ile Val 
        35                  40                  45              


Ile Asp Gly Lys Glu Val Glu Ile Leu Asp Ala Lys Ala Leu Glu Asp 
    50                  55                  60                  


Gln Ala Gly Thr Asn Leu Glu Ile Thr Ile Ile Thr Leu Lys Arg Asn 
65                  70                  75                  80  


Glu Lys Phe Arg Asp Ile Arg Pro His Ile Pro Thr Gln Ile Thr Glu 
                85                  90                  95      


Thr Asn Asp Gly Val Leu Ile Val Asn Thr Ser Lys Tyr Pro Asn Met 
            100                 105                 110         


Tyr Val Pro Val Gly Ala Val Thr Glu Gln Gly Tyr Leu Asn Leu Gly 
        115                 120                 125             


Gly Arg Gln Thr Ala Arg Thr Leu Met Tyr Asn Phe Pro Thr Arg Ala 
    130                 135                 140                 


Gly Gln Cys Gly Gly Val Ile Thr Cys Thr Gly Lys Val Ile Gly Met 
145                 150                 155                 160 


His Val Gly Gly Asn Gly Ser His Gly Phe Ala Ala Ala Leu Lys Arg 
                165                 170                 175     


Ser Tyr Phe Thr Gln Ser 
            180         


<210>  8
<211>  880
<212>  PRT
<213>  Poliovirus Serotype 1 P1

<400>  8

Gly Ala Gln Val Ser Ser Gln Lys Val Gly Ala His Glu Asn Ser Asn 
1               5                   10                  15      


Arg Ala Tyr Gly Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr Tyr 
            20                  25                  30          


Arg Asp Ser Ala Ser Asn Ala Ala Ser Lys Gln Asp Phe Ser Gln Asp 
        35                  40                  45              


Pro Ser Lys Phe Thr Glu Pro Ile Lys Asp Val Leu Ile Lys Thr Ala 
    50                  55                  60                  


Pro Met Leu Asn Ser Pro Asn Ile Glu Ala Cys Gly Tyr Ser Asp Arg 
65                  70                  75                  80  


Val Leu Gln Leu Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu Ala 
                85                  90                  95      


Ala Asn Ser Val Val Ala Tyr Gly Arg Trp Pro Glu Tyr Leu Arg Asp 
            100                 105                 110         


Ser Glu Ala Asn Pro Val Asp Gln Pro Thr Glu Pro Asp Val Ala Ala 
        115                 120                 125             


Cys Arg Phe Tyr Thr Leu Asp Thr Val Ser Trp Thr Lys Glu Ser Arg 
    130                 135                 140                 


Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Arg Asp Met Gly Leu Phe 
145                 150                 155                 160 


Gly Gln Asn Met Tyr Tyr His Tyr Leu Gly Arg Ser Gly Tyr Thr Val 
                165                 170                 175     


His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Gly Val 
            180                 185                 190         


Phe Ala Val Pro Glu Met Cys Leu Ala Gly Asp Ser Asn Thr Thr Thr 
        195                 200                 205             


Met His Thr Ser Tyr Gln Asn Ala Asn Pro Gly Glu Lys Gly Gly Thr 
    210                 215                 220                 


Phe Thr Gly Thr Phe Thr Pro Asp Asn Asn Gln Thr Ser Pro Ala Arg 
225                 230                 235                 240 


Arg Phe Cys Pro Val Asp Tyr Leu Leu Gly Asn Gly Thr Leu Leu Gly 
                245                 250                 255     


Asn Ala Phe Val Phe Pro His Gln Ile Ile Asn Leu Arg Thr Asn Asn 
            260                 265                 270         


Cys Ala Thr Leu Val Leu Pro Tyr Val Asn Ser Leu Ser Ile Asp Ser 
        275                 280                 285             


Met Val Lys His Asn Asn Trp Gly Ile Ala Ile Leu Pro Leu Ala Pro 
    290                 295                 300                 


Leu Asn Phe Ala Ser Glu Ser Ser Pro Glu Ile Pro Ile Thr Leu Thr 
305                 310                 315                 320 


Ile Ala Pro Met Cys Cys Glu Phe Asn Gly Leu Arg Asn Ile Thr Leu 
                325                 330                 335     


Pro Arg Leu Gln Gly Leu Pro Val Met Asn Thr Pro Gly Ser Asn Gln 
            340                 345                 350         


Tyr Leu Thr Ala Asp Asn Phe Gln Ser Pro Cys Ala Leu Pro Glu Phe 
        355                 360                 365             


Asp Val Thr Pro Pro Ile Asp Ile Pro Gly Glu Val Lys Asn Met Met 
    370                 375                 380                 


Glu Leu Ala Glu Ile Asp Thr Met Ile Pro Phe Asp Leu Ser Ala Thr 
385                 390                 395                 400 


Lys Lys Asn Thr Met Glu Met Tyr Arg Val Arg Leu Ser Asp Lys Pro 
                405                 410                 415     


His Thr Asp Asp Pro Ile Leu Cys Leu Ser Leu Ser Pro Ala Ser Asp 
            420                 425                 430         


Pro Arg Leu Ser His Thr Met Leu Gly Glu Ile Leu Asn Tyr Tyr Thr 
        435                 440                 445             


His Trp Ala Gly Ser Leu Lys Phe Thr Phe Leu Phe Cys Gly Phe Met 
    450                 455                 460                 


Met Ala Thr Gly Lys Leu Leu Val Ser Tyr Ala Pro Pro Gly Ala Asp 
465                 470                 475                 480 


Pro Pro Lys Lys Arg Lys Glu Ala Met Leu Gly Thr His Val Ile Trp 
                485                 490                 495     


Asp Ile Gly Leu Gln Ser Ser Cys Thr Met Val Val Pro Trp Ile Ser 
            500                 505                 510         


Asn Thr Thr Tyr Arg Gln Thr Ile Asp Asp Ser Phe Thr Glu Gly Gly 
        515                 520                 525             


Tyr Ile Ser Val Phe Tyr Gln Thr Arg Ile Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Pro Arg Glu Met Asp Ile Leu Gly Phe Val Ser Ala Cys Asn Asp Phe 
545                 550                 555                 560 


Ser Val Arg Leu Leu Arg Asp Thr Thr His Ile Glu Gln Lys Ala Leu 
                565                 570                 575     


Ala Gln Gly Leu Gly Gln Met Leu Glu Ser Met Ile Asp Asn Thr Val 
            580                 585                 590         


Arg Glu Thr Val Gly Ala Ala Thr Ser Arg Asp Ala Leu Pro Asn Thr 
        595                 600                 605             


Glu Ala Ser Gly Pro Thr His Ser Lys Glu Ile Pro Ala Leu Thr Ala 
    610                 615                 620                 


Val Glu Thr Gly Ala Thr Asn Pro Leu Val Pro Ser Asp Thr Val Gln 
625                 630                 635                 640 


Thr Arg His Val Val Gln His Arg Ser Arg Ser Glu Ser Ser Ile Glu 
                645                 650                 655     


Ser Phe Phe Ala Arg Gly Ala Cys Val Thr Ile Met Thr Val Asp Asn 
            660                 665                 670         


Pro Ala Ser Thr Thr Asn Lys Asp Lys Leu Phe Ala Val Trp Lys Ile 
        675                 680                 685             


Thr Tyr Lys Asp Thr Val Gln Leu Arg Arg Lys Leu Glu Phe Phe Thr 
    690                 695                 700                 


Tyr Ser Arg Phe Asp Met Glu Leu Thr Phe Val Val Thr Ala Asn Phe 
705                 710                 715                 720 


Thr Glu Thr Asn Asn Gly His Ala Leu Asn Gln Val Tyr Gln Ile Met 
                725                 730                 735     


Tyr Val Pro Pro Gly Ala Pro Val Pro Glu Lys Trp Asp Asp Tyr Thr 
            740                 745                 750         


Trp Gln Thr Ser Ser Asn Pro Ser Ile Phe Tyr Thr Tyr Gly Thr Ala 
        755                 760                 765             


Pro Ala Arg Ile Ser Val Pro Tyr Val Gly Ile Ser Asn Ala Tyr Ser 
    770                 775                 780                 


His Phe Tyr Asp Gly Phe Ser Lys Val Pro Leu Lys Asp Gln Ser Ala 
785                 790                 795                 800 


Ala Leu Gly Asp Ser Leu Tyr Gly Ala Ala Ser Leu Asn Asp Phe Gly 
                805                 810                 815     


Ile Leu Ala Val Arg Val Val Asn Asp His Asn Pro Thr Lys Val Thr 
            820                 825                 830         


Ser Lys Ile Arg Val Tyr Leu Lys Pro Lys His Ile Arg Val Trp Cys 
        835                 840                 845             


Pro Arg Pro Pro Arg Ala Val Ala Tyr Tyr Gly Pro Gly Val Asp Tyr 
    850                 855                 860                 


Lys Asp Gly Thr Leu Thr Pro Leu Ser Thr Lys Asp Leu Thr Thr Tyr 
865                 870                 875                 880 


<210>  9
<211>  149
<212>  PRT
<213>  Poliovirus Serotype 1 2A

<400>  9

Gly Phe Gly His Gln Asn Lys Ala Val Tyr Thr Ala Gly Tyr Lys Ile 
1               5                   10                  15      


Cys Asn Tyr His Leu Ala Thr Gln Asp Asp Leu Gln Asn Ala Val Asn 
            20                  25                  30          


Val Met Trp Ser Arg Asp Leu Leu Val Thr Glu Ser Arg Ala Gln Gly 
        35                  40                  45              


Thr Asp Ser Ile Ala Arg Cys Asn Cys Asn Ala Gly Val Tyr Tyr Cys 
    50                  55                  60                  


Glu Ser Arg Arg Lys Tyr Tyr Pro Val Ser Phe Val Gly Pro Thr Phe 
65                  70                  75                  80  


Gln Tyr Met Glu Ala Asn Asn Tyr Tyr Pro Ala Arg Tyr Gln Ser His 
                85                  90                  95      


Met Leu Ile Gly His Gly Phe Ala Ser Pro Gly Asp Cys Gly Gly Ile 
            100                 105                 110         


Leu Arg Cys His His Gly Val Ile Gly Ile Ile Thr Ala Gly Gly Glu 
        115                 120                 125             


Gly Leu Val Ala Phe Ser Asp Ile Arg Asp Leu Tyr Ala Tyr Glu Glu 
    130                 135                 140                 


Glu Ala Met Glu Gln 
145                 


