                         SEQUENCE LISTING

<110>  CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y 
       TECNOLOGICAS
       FUNDACION INSTITUTO DE INVESTIGACION SANITARIA FUNDACION 
       JIMENEZ DIAZ
       CENTRO DE INVESTIGACION BIOMEDICA EN RED
       SEGOVIA, Jose C.
       GOMEZ, Maria G.
       NAVARRO, Susana
       MEZA, Nestor
       BUEREN, Juan
       BRAVO, Maria G.
       LAHERTY, Carol D.
 
<120>  COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION OF PKLR

<130>  RTWI-001/01WO 329592-2004

<140>  PCT/US2017/028695
<141>  2017-04-20

<150>  US 62/325,397
<151>  2016-04-20

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  677
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric modified Woodchuck hepatitis virus posttranscriptional 
       regulatory element (Wpre)

<400>  1
cgagcatctt accgccattt attcccatat ttgttctgtt tttcttgatt tgggtataca       60

tttaaatgtt aataaaacaa aatggtgggg caatcattta catttttagg gatatgtaat      120

tactagttca ggtgtattgc cacaagacaa acatgttaag aaactttccc gttatttacg      180

ctctgttcct gttaatcaac ctctggatta caaaatttgt gaaagattga ctgatattct      240

taactatgtt gctcctttta cgctgtgtgg atatgctgct ttaatgcctc tgtatcatgc      300

tattgcttcc cgtacggctt tcgttttctc ctccttgtat aaatcctggt tgctgtctct      360

ttatgaggag ttgtggcccg ttgtccgtca acgtggcgtg gtgtgctctg tgtttgctga      420

cgcaaccccc actggctggg gcattgccac cacctgtcaa ctcctttctg ggactttcgc      480

tttccccctc ccgatcgcca cggcagaact catcgccgcc tgccttgccc gctgctggac      540

aggggctagg ttgctgggca ctgataattc cgtggtgttg tcggggaagg gcctgctgcc      600

ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg      660

ggccgcctcc ccgcctg                                                     677


<210>  2
<211>  28
<212>  DNA
<213>  Human immunodeficiency virus 1

<400>  2
tttaaaagaa aaggggggat tggggggt                                          28


<210>  3
<211>  205
<212>  DNA
<213>  Human immunodeficiency virus 1

<400>  3
tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg acgctgacgg       60

tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg ctgagggcta      120

ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag ctccaggcaa      180

gaatcctggc tgtggaaaga tacct                                            205


<210>  4
<211>  566
<212>  DNA
<213>  Homo sapiens

<400>  4
attatggtaa atccacttac tgtctgccct cgtagccatc gagataaacc ctaccgggta       60

ggggaggcgc ttttcccaag gcagtctgga gcatgcgctt tagcagcccc gctgggcact      120

tggcgctaca caagtggcct ctggcctcgc acacattcca catccaccgg taggcgccaa      180

ccggctccgt tctttggtgg ccccttcgcg ccaccttcta ctcctcccct agtcaggaag      240

ttcccccccg ccccgcagct cgcgtcgtgc aggacgtgac aaatggaagt agcacgtctc      300

actagtctcg tgcagatgga cagcaccgct gagcaatgga agcgggtagg cctttggggc      360

agcggccaat agcagctttg ctccttcgct ttctgggctc agaggctggg aaggggtggg      420

tccgggggcg ggctcagggg cgggctcagg ggcggggcgg gcgcccgaag gtcctccgga      480

ggcccggcat tctgcacgct tcaaaagcgc acgtctgccg cgctgttctc ctcttcctca      540

tctccgggcc tttcgacctg cagccc                                           566


<210>  5
<211>  138
<212>  DNA
<213>  Human immunodeficiency virus 1

<400>  5
tcgacgcagg actcggcttg ctgaagcgcg cacggcaaga ggcgaggggc ggcgactggt       60

gagtacgcca aaaattttga ctagcggagg ctagaaggag agagatgggt gcgagagcgt      120

cagtattaag cgggggag                                                    138


<210>  6
<211>  236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified LTR nucleic acid sequence

<400>  6
tggaagggct aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc       60

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      120

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      180

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagt          236


<210>  7
<211>  235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified LTR nucleic acid sequence

<400>  7
tggaagggct aattcactcc caacgaagac aagatctgct ttttgcttgt actgggtctc       60

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      120

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      180

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcag           235


<210>  8
<211>  516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized codon optimized human PKLR promoter sequence

<400>  8
tccacggggt tggggttgcg ccttttccaa ggcagccctg ggtttgcgca gggacgcggc       60

tgctctgggc gtggttccgg gaaacgcagc ggcgccgacc ctgggtctcg cacattcttc      120

acgtccgttc gcagcgtcac ccggatcttc gccgctaccc ttgtgggccc cccggcgacg      180

cttcctcgtc cgcccctaag tcgggaaggt tccttgcggt tcgcggcgtg ccggacgtga      240

caaacggaag ccgcacgtct cactagtacc ctcgcagacg gacagcgcca gggagcaatg      300

gcagcgcgcc gaccgcgatg ggctgtggcc aatagcggct gctcagcagg ggcgcccgag      360

agcagcggcc gggaaggggc ggtgcgggag gcggggtgtg gggcggtagt gtgggccctg      420

ttcctgcccg cgcggtgttc cgcattctgc aagcctccgg agcgcacgtc ggcagtcggc      480

tccctcgttg accgaatcac cgacctctct ccccag                                516


<210>  9
<211>  677
<212>  DNA
<213>  Woodchuck hepatitis virus

<400>  9
cgagcatctt accgccattt attcccatat ttgttctgtt tttcttgatt tgggtataca       60

tttaaatgtt aataaaacaa aatggtgggg caatcattta catttttagg gatatgtaat      120

tactagttca ggtgtattgc cacaagacaa acatgttaag aaactttccc gttatttacg      180

ctctgttcct gttaatcaac ctctggatta caaaatttgt gaaagattga ctgatattct      240

taactatgtt gctcctttta cgctgtgtgg atatgctgct ttaatgcctc tgtatcatgc      300

tattgcttcc cgtacggctt tcgttttctc ctccttgtat aaatcctggt tgctgtctct      360

ttatgaggag ttgtggcccg ttgtccgtca acgtggcgtg gtgtgctctg tgtttgctga      420

cgcaaccccc actggctggg gcattgccac cacctgtcaa ctcctttctg ggactttcgc      480

tttccccctc ccgatcgcca cggcagaact catcgccgcc tgccttgccc gctgctggac      540

aggggctagg ttgctgggca ctgataattc cgtggtgttg tcggggaagg gcctgctgcc      600

ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg      660

ggccgcctcc ccgcctg                                                     677


