                         SEQUENCE LISTING

<110>  Northwestern University
       Chetkovich, Dane M.
       Han, Ye
 
<120>  A GENE THERAPY BASED ANTIDEPRESSANT

<130>  5369-00379

<150>  US 62/326,464
<151>  2016-04-22

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Ile Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Gly His Gln 
        115                 120                 125             


Gln Asp Ala Cys Asp Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Ser Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  2
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens TPR3-N13A TRIP8b Variant

<400>  2

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Ile Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Ala Thr Gly His Gln 
        115                 120                 125             


Gln Asp Ala Cys Asp Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Ser Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  3
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens TPR2-E15K TRIP8b Variant

<400>  3

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Ile Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Lys Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Gly His Gln 
        115                 120                 125             


Gln Asp Ala Cys Asp Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Ser Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  4
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens TPR5-N5A TRIP8b Variant

<400>  4

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Ile Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Gly His Gln 
        115                 120                 125             


Gln Asp Ala Cys Asp Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Ser Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Ala Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  5
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Homo sapiens TPR6-R2A TRIP8b Variant

<400>  5

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Ile Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Gly His Gln 
        115                 120                 125             


Gln Asp Ala Cys Asp Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Ser Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Ala Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  6
<211>  344
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Val Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Ser His Gln 
        115                 120                 125             


Gln Asp Ala Cys Glu Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Asn Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  7
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Mus musculus TPR3-N13A TRIP8b Variant

<400>  7

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Val Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Ala Thr Ser His Gln 
        115                 120                 125             


Gln Asp Ala Cys Glu Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Asn Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  8
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Mus musculus TPR2-E15K TRIP8b Variant

<400>  8

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Val Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Lys Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Ser His Gln 
        115                 120                 125             


Gln Asp Ala Cys Glu Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Asn Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  9
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Mus musculus TPR5-N5A TRIP8b Variant

<400>  9

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Val Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Ser His Gln 
        115                 120                 125             


Gln Asp Ala Cys Glu Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Asn Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Ala Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Arg Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


<210>  10
<211>  344
<212>  PRT
<213>  Artificial

<220>
<223>  Mus musculus TPR6-R2A TRIP8b Variant

<400>  10

Met Gln Ala Glu Trp Glu Glu Met Ala Arg Arg Asn Trp Ile Ser Glu 
1               5                   10                  15      


Asn Gln Glu Ala Gln Asn Gln Val Thr Val Ser Ala Ser Glu Lys Gly 
            20                  25                  30          


Tyr Tyr Phe His Thr Glu Asn Pro Phe Lys Asp Trp Pro Gly Ala Phe 
        35                  40                  45              


Glu Glu Gly Leu Lys Arg Leu Lys Glu Gly Asp Leu Pro Val Thr Ile 
    50                  55                  60                  


Leu Phe Met Glu Ala Ala Ile Leu Gln Asp Pro Gly Asp Ala Glu Ala 
65                  70                  75                  80  


Trp Gln Phe Leu Gly Ile Thr Gln Ala Glu Asn Glu Asn Glu Gln Ala 
                85                  90                  95      


Ala Ile Val Ala Leu Gln Arg Cys Leu Glu Leu Gln Pro Asn Asn Leu 
            100                 105                 110         


Lys Ala Leu Met Ala Leu Ala Val Ser Tyr Thr Asn Thr Ser His Gln 
        115                 120                 125             


Gln Asp Ala Cys Glu Ala Leu Lys Asn Trp Ile Lys Gln Asn Pro Lys 
    130                 135                 140                 


Tyr Lys Tyr Leu Val Lys Asn Lys Lys Gly Ser Pro Gly Leu Thr Arg 
145                 150                 155                 160 


Arg Met Ser Lys Ser Pro Val Asp Ser Ser Val Leu Glu Gly Val Lys 
                165                 170                 175     


Glu Leu Tyr Leu Glu Ala Ala His Gln Asn Gly Asp Met Ile Asp Pro 
            180                 185                 190         


Asp Leu Gln Thr Gly Leu Gly Val Leu Phe His Leu Ser Gly Glu Phe 
        195                 200                 205             


Asn Arg Ala Ile Asp Ala Phe Asn Ala Ala Leu Thr Val Arg Pro Glu 
    210                 215                 220                 


Asp Tyr Ser Leu Trp Asn Arg Leu Gly Ala Thr Leu Ala Asn Gly Asp 
225                 230                 235                 240 


Arg Ser Glu Glu Ala Val Glu Ala Tyr Thr Arg Ala Leu Glu Ile Gln 
                245                 250                 255     


Pro Gly Phe Ile Ala Ser Arg Tyr Asn Leu Gly Ile Ser Cys Ile Asn 
            260                 265                 270         


Leu Gly Ala Tyr Arg Glu Ala Val Ser Asn Phe Leu Thr Ala Leu Ser 
        275                 280                 285             


Leu Gln Arg Lys Ser Arg Asn Gln Gln Gln Val Pro His Pro Ala Ile 
    290                 295                 300                 


Ser Gly Asn Ile Trp Ala Ala Leu Arg Ile Ala Leu Ser Leu Met Asp 
305                 310                 315                 320 


Gln Pro Glu Leu Phe Gln Ala Ala Asn Leu Gly Asp Leu Asp Val Leu 
                325                 330                 335     


Leu Arg Ala Phe Asn Leu Asp Pro 
            340                 


