
                                SEQUENCE LISTING

<110> Five Prime Therapeutics, Inc.
      GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
      Hsu, Amy W.
      Power, Janine
      Hinken, Aaron Curtis
      Russell, Allan James
      Rocque, Warren James
      

<120> NOPE FOR TREATMENT OF PATHOLOGICAL
  MUSCLE LOSS AND WEAKNESS

<130> PU66034

<150> 62/326914           
<151> 2016-04-25  

<160> 28

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1250
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE precursor (1-1250), with signal
      peptide.

<400> 1
Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr
 1               5                  10                  15      
Phe Cys Leu Leu Ala Ala Arg Gly Glu Leu Leu Leu Pro Gln Glu Thr
            20                  25                  30          
Thr Val Glu Leu Ser Cys Gly Val Gly Pro Leu Gln Val Ile Leu Gly
        35                  40                  45              
Pro Glu Gln Ala Ala Val Leu Asn Cys Ser Leu Gly Ala Ala Ala Ala
    50                  55                  60                  
Gly Pro Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Leu Leu
65                  70                  75                  80  
Glu His Asp His Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser
                85                  90                  95      
Gln Pro Leu Ala Pro Asn Gly Ser Asp Glu Ser Val Pro Glu Ala Val
            100                 105                 110         
Gly Val Ile Glu Gly Asn Tyr Ser Cys Leu Ala His Gly Pro Leu Gly
        115                 120                 125             
Val Leu Ala Ser Gln Thr Ala Val Val Lys Leu Ala Thr Leu Ala Asp
    130                 135                 140                 
Phe Ser Leu His Pro Glu Ser Gln Thr Val Glu Glu Asn Gly Thr Ala
145                 150                 155                 160 
Arg Phe Glu Cys His Ile Glu Gly Leu Pro Ala Pro Ile Ile Thr Trp
                165                 170                 175     
Glu Lys Asp Gln Val Thr Leu Pro Glu Glu Pro Arg Leu Ile Val Leu
            180                 185                 190         
Pro Asn Gly Val Leu Gln Ile Leu Asp Val Gln Glu Ser Asp Ala Gly
        195                 200                 205             
Pro Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln His Phe Ser Gln
    210                 215                 220                 
Glu Ala Leu Leu Ser Val Ala His Arg Gly Ser Leu Ala Ser Thr Arg
225                 230                 235                 240 
Gly Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val
                245                 250                 255     
Ser Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr
            260                 265                 270         
Pro Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp
        275                 280                 285             
Val Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Asn Ala Gln Pro
    290                 295                 300                 
Trp His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg
305                 310                 315                 320 
Asp Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala
                325                 330                 335     
Ile Thr Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala
            340                 345                 350         
Arg Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu Arg Trp
        355                 360                 365             
Leu His Asn Gly Ala Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln
    370                 375                 380                 
Gly Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala
385                 390                 395                 400 
Gly Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Met Ala Cys Ala
                405                 410                 415     
Ala Ala Ser Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro
            420                 425                 430         
Thr Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ala Val Leu Val Ala
        435                 440                 445             
Trp Glu Arg Pro Glu Met His Ser Glu Gln Ile Ile Gly Phe Ser Leu
    450                 455                 460                 
His Tyr Gln Lys Ala Arg Gly Met Asp Asn Val Glu Tyr Gln Phe Ala
465                 470                 475                 480 
Val Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn
                485                 490                 495     
Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser
            500                 505                 510         
Arg Thr Ser Thr Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser
        515                 520                 525             
Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg
    530                 535                 540                 
Val Ala Trp Leu Pro Leu Pro Pro Ser Leu Ser Asn Gly Gln Val Val
545                 550                 555                 560 
Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Ile Phe Ser
                565                 570                 575     
Thr Glu Val Arg Gly Asn Glu Thr Gln Leu Met Leu Asn Ser Leu Gln
            580                 585                 590         
Pro Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Ala Ala Gly
        595                 600                 605             
Phe Gly Ala Pro Ser Gln Trp Met His His Arg Thr Pro Ser Met His
    610                 615                 620                 
Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Gln Ala
625                 630                 635                 640 
Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr
                645                 650                 655     
Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala Glu Glu
            660                 665                 670         
Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln Ala Trp
        675                 680                 685             
Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu
    690                 695                 700                 
Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe
705                 710                 715                 720 
Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu
                725                 730                 735     
Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro Leu Pro
            740                 745                 750         
Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu
        755                 760                 765             
Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr
    770                 775                 780                 
Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr
785                 790                 795                 800 
Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe
                805                 810                 815     
Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly
            820                 825                 830         
Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser
        835                 840                 845             
Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val
    850                 855                 860                 
Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu
865                 870                 875                 880 
Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His Gln Trp
                885                 890                 895     
Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val His Gly
            900                 905                 910         
Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu
        915                 920                 925             
Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln
    930                 935                 940                 
Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Val Thr Gly Ile Ile
945                 950                 955                 960 
Val Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala
                965                 970                 975     
Gly Leu Arg Arg Ser Pro His Arg Glu Ser Leu Pro Gly Leu Ser Ser
            980                 985                 990         
Thr Ala Thr Pro Gly Asn Pro Ala Leu Tyr Ser Arg Ala Arg Leu Gly
        995                 1000                1005            
Pro Pro Ser Pro Pro Ala Ala His Glu Leu Glu Ser Leu Val His Pro
    1010                1015                1020                
His Pro Gln Asp Trp Ser Pro Pro Pro Ser Asp Val Glu Asp Arg Ala
1025                1030                1035               1040 
Glu Val His Ser Leu Met Gly Gly Gly Val Ser Glu Gly Arg Ser His
                1045                1050                1055    
Ser Lys Arg Lys Ile Ser Trp Ala Gln Pro Ser Gly Leu Ser Trp Ala
            1060                1065                1070        
Gly Ser Trp Ala Gly Cys Glu Leu Pro Gln Ala Gly Pro Arg Pro Ala
        1075                1080                1085            
Leu Thr Arg Ala Leu Leu Pro Pro Ala Gly Thr Gly Gln Thr Leu Leu
    1090                1095                1100                
Leu Gln Ala Leu Val Tyr Asp Ala Ile Lys Gly Asn Gly Arg Lys Lys
1105                1110                1115               1120 
Ser Pro Pro Ala Cys Arg Asn Gln Val Glu Ala Glu Val Ile Val His
                1125                1130                1135    
Ser Asp Phe Ser Ala Ser Asn Gly Asn Pro Asp Leu His Leu Gln Asp
            1140                1145                1150        
Leu Glu Pro Glu Asp Pro Leu Pro Pro Glu Ala Pro Asp Leu Ile Ser
        1155                1160                1165            
Gly Val Gly Asp Pro Gly Gln Gly Ala Ala Trp Leu Asp Arg Glu Leu
    1170                1175                1180                
Gly Gly Cys Glu Leu Ala Ala Pro Gly Pro Asp Arg Leu Thr Cys Leu
1185                1190                1195               1200 
Pro Glu Ala Ala Ser Ala Ser Cys Ser Tyr Pro Asp Leu Gln Pro Gly
                1205                1210                1215    
Glu Val Leu Glu Glu Thr Pro Gly Asp Ser Cys Gln Leu Lys Ser Pro
            1220                1225                1230        
Cys Pro Leu Gly Ala Ser Pro Gly Leu Pro Arg Ser Pro Val Ser Ser
        1235                1240                1245            
Ser Ala
    1250


<210> 2
<211> 1226
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human mature NOPE (25-1250), without signal
      peptide.

<400> 2
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
                405                 410                 415     
Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
            420                 425                 430         
Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
        435                 440                 445             
Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
    450                 455                 460                 
Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
465                 470                 475                 480 
Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
                485                 490                 495     
His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
            500                 505                 510         
Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
        515                 520                 525             
Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
    530                 535                 540                 
Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
545                 550                 555                 560 
Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
                565                 570                 575     
Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
            580                 585                 590         
His His Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala
        595                 600                 605             
Pro Ala Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser
    610                 615                 620                 
Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr
625                 630                 635                 640 
Trp Arg Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro
                645                 650                 655     
Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys
            660                 665                 670         
Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu
        675                 680                 685             
Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala
    690                 695                 700                 
Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro
705                 710                 715                 720 
Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser
                725                 730                 735     
Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr
            740                 745                 750         
Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu
        755                 760                 765             
Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile
    770                 775                 780                 
Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln
785                 790                 795                 800 
Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg
                805                 810                 815     
Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu
            820                 825                 830         
Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr
        835                 840                 845             
Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn
    850                 855                 860                 
His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn
865                 870                 875                 880 
Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe
                885                 890                 895     
Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg
            900                 905                 910         
Leu Gln Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp
        915                 920                 925             
Met His Ser Val Thr Gly Ile Ile Val Gly Val Cys Leu Gly Leu Leu
    930                 935                 940                 
Cys Leu Leu Ala Cys Met Cys Ala Gly Leu Arg Arg Ser Pro His Arg
945                 950                 955                 960 
Glu Ser Leu Pro Gly Leu Ser Ser Thr Ala Thr Pro Gly Asn Pro Ala
                965                 970                 975     
Leu Tyr Ser Arg Ala Arg Leu Gly Pro Pro Ser Pro Pro Ala Ala His
            980                 985                 990         
Glu Leu Glu Ser Leu Val His Pro His Pro Gln Asp Trp Ser Pro Pro
        995                 1000                1005            
Pro Ser Asp Val Glu Asp Arg Ala Glu Val His Ser Leu Met Gly Gly
    1010                1015                1020                
Gly Val Ser Glu Gly Arg Ser His Ser Lys Arg Lys Ile Ser Trp Ala
1025                1030                1035               1040 
Gln Pro Ser Gly Leu Ser Trp Ala Gly Ser Trp Ala Gly Cys Glu Leu
                1045                1050                1055    
Pro Gln Ala Gly Pro Arg Pro Ala Leu Thr Arg Ala Leu Leu Pro Pro
            1060                1065                1070        
Ala Gly Thr Gly Gln Thr Leu Leu Leu Gln Ala Leu Val Tyr Asp Ala
        1075                1080                1085            
Ile Lys Gly Asn Gly Arg Lys Lys Ser Pro Pro Ala Cys Arg Asn Gln
    1090                1095                1100                
Val Glu Ala Glu Val Ile Val His Ser Asp Phe Ser Ala Ser Asn Gly
1105                1110                1115               1120 
Asn Pro Asp Leu His Leu Gln Asp Leu Glu Pro Glu Asp Pro Leu Pro
                1125                1130                1135    
Pro Glu Ala Pro Asp Leu Ile Ser Gly Val Gly Asp Pro Gly Gln Gly
            1140                1145                1150        
Ala Ala Trp Leu Asp Arg Glu Leu Gly Gly Cys Glu Leu Ala Ala Pro
        1155                1160                1165            
Gly Pro Asp Arg Leu Thr Cys Leu Pro Glu Ala Ala Ser Ala Ser Cys
    1170                1175                1180                
Ser Tyr Pro Asp Leu Gln Pro Gly Glu Val Leu Glu Glu Thr Pro Gly
1185                1190                1195               1200 
Asp Ser Cys Gln Leu Lys Ser Pro Cys Pro Leu Gly Ala Ser Pro Gly
                1205                1210                1215    
Leu Pro Arg Ser Pro Val Ser Ser Ser Ala
            1220                1225    


<210> 3
<211> 1252
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse NOPE precursor (1-1252), with signal
      peptide.

<400> 3
Met Ala Arg Ala Asp Thr Gly Arg Gly Leu Leu Val Leu Thr Phe Cys
 1               5                  10                  15      
Leu Leu Ser Ala Arg Gly Glu Leu Pro Leu Pro Gln Glu Thr Thr Val
            20                  25                  30          
Lys Leu Ser Cys Asp Glu Gly Pro Leu Gln Val Ile Leu Gly Pro Glu
        35                  40                  45              
Gln Ala Val Val Leu Asp Cys Thr Leu Gly Ala Thr Ala Ala Gly Pro
    50                  55                  60                  
Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Val Leu Glu His
65                  70                  75                  80  
Glu Asn Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser Ser Pro
                85                  90                  95      
Leu Glu Gln Glu Asp Ser Asp Asp Glu Glu Ala Leu Arg Ile Trp Lys
            100                 105                 110         
Val Thr Glu Gly Ser Tyr Ser Cys Leu Ala His Ser Pro Leu Gly Val
        115                 120                 125             
Val Ala Ser Gln Val Ala Val Val Lys Leu Ala Thr Leu Glu Asp Phe
    130                 135                 140                 
Ser Leu His Pro Glu Ser Gln Ile Val Glu Glu Asn Gly Thr Ala Arg
145                 150                 155                 160 
Phe Glu Cys His Thr Lys Gly Leu Pro Ala Pro Ile Ile Thr Trp Glu
                165                 170                 175     
Lys Asp Gln Val Thr Val Pro Glu Glu Ser Arg Leu Ile Thr Leu Pro
            180                 185                 190         
Asn Gly Val Leu Gln Ile Leu Asp Val Gln Asp Ser Asp Ala Gly Ser
        195                 200                 205             
Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln Arg Phe Ser Gln Glu
    210                 215                 220                 
Ala Ser Leu Thr Val Ala Leu Arg Gly Ser Leu Glu Ala Thr Arg Gly
225                 230                 235                 240 
Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val Ser
                245                 250                 255     
Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr Pro
            260                 265                 270         
Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp Val
        275                 280                 285             
Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Ser Ala Gln Pro Arg
    290                 295                 300                 
His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg Asp
305                 310                 315                 320 
Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala Ile
                325                 330                 335     
Ser Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala Arg
            340                 345                 350         
Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu His Trp Leu
        355                 360                 365             
His Asp Gly Ile Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln Gly
    370                 375                 380                 
Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala Gly
385                 390                 395                 400 
Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Thr Ala Cys Ala Ala
                405                 410                 415     
Ala Pro Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro Thr
            420                 425                 430         
Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ser Val Leu Val Ala Trp
        435                 440                 445             
Glu Arg Pro Glu Leu His Ser Glu Gln Ile Ile Gly Phe Ser Leu His
    450                 455                 460                 
Tyr Gln Lys Ala Arg Gly Val Asp Asn Val Glu Tyr Gln Phe Ala Val
465                 470                 475                 480 
Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn Thr
                485                 490                 495     
Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser Arg
            500                 505                 510         
Thr Ser Ser Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser Ala
        515                 520                 525             
Ala Pro Gln Leu Thr Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg Val
    530                 535                 540                 
Ala Trp Leu Pro Leu Pro Ser Ser Leu Ser Asn Gly Gln Val Leu Lys
545                 550                 555                 560 
Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Val Phe Ser Thr
                565                 570                 575     
Glu Val Pro Gly Asn Glu Thr Gln Leu Thr Leu Asn Ser Leu Gln Pro
            580                 585                 590         
Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Gly Ala Gly Tyr
        595                 600                 605             
Gly Val Pro Ser Gln Trp Met Gln His Arg Thr Pro Gly Val His Asn
    610                 615                 620                 
Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Arg Ala Lys
625                 630                 635                 640 
Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr Gln
                645                 650                 655     
Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Thr Glu Glu Glu
            660                 665                 670         
Ala Asp Gly Asp Arg Pro Pro Gly Gly Arg Gly Asp Gln Ala Trp Asp
        675                 680                 685             
Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu Thr
    690                 695                 700                 
Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe Asn
705                 710                 715                 720 
Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu Lys
                725                 730                 735     
Ala Pro Thr Pro Asp Leu Pro Ile Gln Arg Gly Pro Pro Leu Pro Pro
            740                 745                 750         
Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu Arg
        755                 760                 765             
Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr Val
    770                 775                 780                 
Arg Phe Gly Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr Tyr
785                 790                 795                 800 
Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe Thr
                805                 810                 815     
Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly Pro
            820                 825                 830         
Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser Thr
        835                 840                 845             
Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val Arg
    850                 855                 860                 
Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu Tyr
865                 870                 875                 880 
Leu Ile Leu Tyr Ser Asn Asn His Thr Gln Pro Glu His Gln Trp Thr
                885                 890                 895     
Leu Leu Thr Thr Glu Gly Asn Ile Phe Ser Ala Glu Val His Gly Leu
            900                 905                 910         
Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu Val
        915                 920                 925             
Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln Lys
    930                 935                 940                 
Thr Phe Ser Asp Ser Leu Asp Val His Ala Val Thr Gly Ile Ile Val
945                 950                 955                 960 
Gly Val Cys Leu Gly Leu Leu Cys Leu Leu Ala Cys Met Cys Ala Gly
                965                 970                 975     
Leu Arg Arg Ser Ser His Arg Glu Ala Leu Pro Gly Leu Ser Ser Ser
            980                 985                 990         
Gly Thr Pro Gly Asn Pro Ala Leu Tyr Thr Arg Ala Arg Leu Gly Pro
        995                 1000                1005            
Pro Ser Val Pro Ala Ala His Glu Leu Glu Ser Leu Val His Pro Arg
    1010                1015                1020                
Pro Gln Asp Trp Ser Pro Pro Pro Ser Asp Val Glu Asp Lys Ala Glu
1025                1030                1035               1040 
Val His Ser Leu Met Gly Gly Ser Val Ser Asp Cys Arg Gly His Ser
                1045                1050                1055    
Lys Arg Lys Ile Ser Trp Ala Gln Ala Gly Gly Pro Asn Trp Ala Gly
            1060                1065                1070        
Ser Trp Ala Gly Cys Glu Leu Pro Gln Gly Ser Gly Pro Arg Pro Ala
        1075                1080                1085            
Leu Thr Arg Ala Leu Leu Pro Pro Ala Gly Thr Gly Gln Thr Leu Leu
    1090                1095                1100                
Leu Gln Ala Leu Val Tyr Asp Ala Ile Lys Ser Asn Gly Arg Lys Lys
1105                1110                1115               1120 
Pro Ser Pro Ala Cys Arg Asn Gln Val Glu Ala Glu Val Ile Val His
                1125                1130                1135    
Ser Asp Phe Gly Ala Ser Lys Gly Cys Pro Asp Leu His Leu Gln Asp
            1140                1145                1150        
Leu Glu Pro Glu Glu Pro Leu Thr Ala Glu Thr Leu Pro Ser Thr Ser
        1155                1160                1165            
Gly Ala Val Asp Leu Ser Gln Gly Ala Asp Trp Leu Gly Arg Glu Leu
    1170                1175                1180                
Gly Gly Cys Gln Pro Thr Thr Ser Gly Pro Glu Arg Leu Thr Cys Leu
1185                1190                1195               1200 
Pro Glu Ala Ala Ser Ala Ser Cys Ser Cys Ser Asp Leu Gln Pro Ser
                1205                1210                1215    
Thr Ala Ile Glu Glu Ala Pro Gly Lys Ser Cys Gln Pro Lys Ala Leu
            1220                1225                1230        
Cys Pro Leu Thr Val Ser Pro Ser Leu Pro Arg Ala Pro Val Ser Ser
        1235                1240                1245            
Ala Gln Val Pro
    1250        


<210> 4
<211> 1230
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse mature NOPE (23-1252), without signal
      peptide.

<400> 4
Glu Leu Pro Leu Pro Gln Glu Thr Thr Val Lys Leu Ser Cys Asp Glu
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Val Val Leu Asp
            20                  25                  30          
Cys Thr Leu Gly Ala Thr Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Val Leu Glu His Glu Asn Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Ser Pro Leu Glu Gln Glu Asp Ser
65                  70                  75                  80  
Asp Asp Glu Glu Ala Leu Arg Ile Trp Lys Val Thr Glu Gly Ser Tyr
                85                  90                  95      
Ser Cys Leu Ala His Ser Pro Leu Gly Val Val Ala Ser Gln Val Ala
            100                 105                 110         
Val Val Lys Leu Ala Thr Leu Glu Asp Phe Ser Leu His Pro Glu Ser
        115                 120                 125             
Gln Ile Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Thr Lys
    130                 135                 140                 
Gly Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Val
145                 150                 155                 160 
Pro Glu Glu Ser Arg Leu Ile Thr Leu Pro Asn Gly Val Leu Gln Ile
                165                 170                 175     
Leu Asp Val Gln Asp Ser Asp Ala Gly Ser Tyr Arg Cys Val Ala Thr
            180                 185                 190         
Asn Ser Ala Arg Gln Arg Phe Ser Gln Glu Ala Ser Leu Thr Val Ala
        195                 200                 205             
Leu Arg Gly Ser Leu Glu Ala Thr Arg Gly Gln Asp Val Val Ile Val
    210                 215                 220                 
Ala Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met
225                 230                 235                 240 
Glu Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg
                245                 250                 255     
Gln Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr
            260                 265                 270         
Asn Leu Leu Ile Ala Ser Ala Gln Pro Arg His Ser Gly Val Tyr Val
        275                 280                 285             
Cys Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala
    290                 295                 300                 
Glu Leu Arg Val Leu Ala Ala Pro Ala Ile Ser Gln Ala Pro Glu Ala
305                 310                 315                 320 
Leu Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser
                325                 330                 335     
Gly Glu Pro Arg Pro Ala Leu His Trp Leu His Asp Gly Ile Pro Leu
            340                 345                 350         
Arg Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val
        355                 360                 365             
Ile Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala
    370                 375                 380                 
Glu Asn Ser Ala Gly Thr Ala Cys Ala Ala Ala Pro Leu Ala Val Val
385                 390                 395                 400 
Val Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro
                405                 410                 415     
Leu Ser Ser Ser Ser Val Leu Val Ala Trp Glu Arg Pro Glu Leu His
            420                 425                 430         
Ser Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly
        435                 440                 445             
Val Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu
    450                 455                 460                 
Leu Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val
465                 470                 475                 480 
Val Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Ser Pro Ala Leu
                485                 490                 495     
Val His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Thr Leu
            500                 505                 510         
Ser Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro
        515                 520                 525             
Ser Ser Leu Ser Asn Gly Gln Val Leu Lys Tyr Lys Ile Glu Tyr Gly
    530                 535                 540                 
Leu Gly Lys Glu Asp Gln Val Phe Ser Thr Glu Val Pro Gly Asn Glu
545                 550                 555                 560 
Thr Gln Leu Thr Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val
                565                 570                 575     
Arg Ile Ser Ala Gly Thr Gly Ala Gly Tyr Gly Val Pro Ser Gln Trp
            580                 585                 590         
Met Gln His Arg Thr Pro Gly Val His Asn Gln Ser His Val Pro Phe
        595                 600                 605             
Ala Pro Ala Glu Leu Lys Val Arg Ala Lys Met Glu Ser Leu Val Val
    610                 615                 620                 
Ser Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu
625                 630                 635                 640 
Tyr Trp Arg Glu Val Gly Thr Glu Glu Glu Ala Asp Gly Asp Arg Pro
                645                 650                 655     
Pro Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu
            660                 665                 670         
Lys Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg
        675                 680                 685             
Leu Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr
    690                 695                 700                 
Ala Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Thr Pro Asp Leu
705                 710                 715                 720 
Pro Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu
                725                 730                 735     
Ser Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe
            740                 745                 750         
Thr Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Gly Pro Trp Gly
        755                 760                 765             
Leu Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp
    770                 775                 780                 
Ile Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val
785                 790                 795                 800 
Gln Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu
                805                 810                 815     
Arg Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg
            820                 825                 830         
Leu Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro
        835                 840                 845             
Thr Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Asn
    850                 855                 860                 
Asn His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Glu Gly
865                 870                 875                 880 
Asn Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr
                885                 890                 895     
Phe Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser
            900                 905                 910         
Arg Leu Gln Asp Val Ile Thr Leu Gln Lys Thr Phe Ser Asp Ser Leu
        915                 920                 925             
Asp Val His Ala Val Thr Gly Ile Ile Val Gly Val Cys Leu Gly Leu
    930                 935                 940                 
Leu Cys Leu Leu Ala Cys Met Cys Ala Gly Leu Arg Arg Ser Ser His
945                 950                 955                 960 
Arg Glu Ala Leu Pro Gly Leu Ser Ser Ser Gly Thr Pro Gly Asn Pro
                965                 970                 975     
Ala Leu Tyr Thr Arg Ala Arg Leu Gly Pro Pro Ser Val Pro Ala Ala
            980                 985                 990         
His Glu Leu Glu Ser Leu Val His Pro Arg Pro Gln Asp Trp Ser Pro
        995                 1000                1005            
Pro Pro Ser Asp Val Glu Asp Lys Ala Glu Val His Ser Leu Met Gly
    1010                1015                1020                
Gly Ser Val Ser Asp Cys Arg Gly His Ser Lys Arg Lys Ile Ser Trp
1025                1030                1035               1040 
Ala Gln Ala Gly Gly Pro Asn Trp Ala Gly Ser Trp Ala Gly Cys Glu
                1045                1050                1055    
Leu Pro Gln Gly Ser Gly Pro Arg Pro Ala Leu Thr Arg Ala Leu Leu
            1060                1065                1070        
Pro Pro Ala Gly Thr Gly Gln Thr Leu Leu Leu Gln Ala Leu Val Tyr
        1075                1080                1085            
Asp Ala Ile Lys Ser Asn Gly Arg Lys Lys Pro Ser Pro Ala Cys Arg
    1090                1095                1100                
Asn Gln Val Glu Ala Glu Val Ile Val His Ser Asp Phe Gly Ala Ser
1105                1110                1115               1120 
Lys Gly Cys Pro Asp Leu His Leu Gln Asp Leu Glu Pro Glu Glu Pro
                1125                1130                1135    
Leu Thr Ala Glu Thr Leu Pro Ser Thr Ser Gly Ala Val Asp Leu Ser
            1140                1145                1150        
Gln Gly Ala Asp Trp Leu Gly Arg Glu Leu Gly Gly Cys Gln Pro Thr
        1155                1160                1165            
Thr Ser Gly Pro Glu Arg Leu Thr Cys Leu Pro Glu Ala Ala Ser Ala
    1170                1175                1180                
Ser Cys Ser Cys Ser Asp Leu Gln Pro Ser Thr Ala Ile Glu Glu Ala
1185                1190                1195               1200 
Pro Gly Lys Ser Cys Gln Pro Lys Ala Leu Cys Pro Leu Thr Val Ser
                1205                1210                1215    
Pro Ser Leu Pro Arg Ala Pro Val Ser Ser Ala Gln Val Pro
            1220                1225                1230


<210> 5
<211> 957
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE extracellular domain (ECD) (1-957),
      with signal peptide.

<400> 5
Met Ala Arg Gly Asp Ala Gly Arg Gly Arg Gly Leu Leu Ala Leu Thr
 1               5                  10                  15      
Phe Cys Leu Leu Ala Ala Arg Gly Glu Leu Leu Leu Pro Gln Glu Thr
            20                  25                  30          
Thr Val Glu Leu Ser Cys Gly Val Gly Pro Leu Gln Val Ile Leu Gly
        35                  40                  45              
Pro Glu Gln Ala Ala Val Leu Asn Cys Ser Leu Gly Ala Ala Ala Ala
    50                  55                  60                  
Gly Pro Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Leu Leu
65                  70                  75                  80  
Glu His Asp His Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser
                85                  90                  95      
Gln Pro Leu Ala Pro Asn Gly Ser Asp Glu Ser Val Pro Glu Ala Val
            100                 105                 110         
Gly Val Ile Glu Gly Asn Tyr Ser Cys Leu Ala His Gly Pro Leu Gly
        115                 120                 125             
Val Leu Ala Ser Gln Thr Ala Val Val Lys Leu Ala Thr Leu Ala Asp
    130                 135                 140                 
Phe Ser Leu His Pro Glu Ser Gln Thr Val Glu Glu Asn Gly Thr Ala
145                 150                 155                 160 
Arg Phe Glu Cys His Ile Glu Gly Leu Pro Ala Pro Ile Ile Thr Trp
                165                 170                 175     
Glu Lys Asp Gln Val Thr Leu Pro Glu Glu Pro Arg Leu Ile Val Leu
            180                 185                 190         
Pro Asn Gly Val Leu Gln Ile Leu Asp Val Gln Glu Ser Asp Ala Gly
        195                 200                 205             
Pro Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln His Phe Ser Gln
    210                 215                 220                 
Glu Ala Leu Leu Ser Val Ala His Arg Gly Ser Leu Ala Ser Thr Arg
225                 230                 235                 240 
Gly Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val
                245                 250                 255     
Ser Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr
            260                 265                 270         
Pro Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp
        275                 280                 285             
Val Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Asn Ala Gln Pro
    290                 295                 300                 
Trp His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg
305                 310                 315                 320 
Asp Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala
                325                 330                 335     
Ile Thr Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala
            340                 345                 350         
Arg Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu Arg Trp
        355                 360                 365             
Leu His Asn Gly Ala Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln
    370                 375                 380                 
Gly Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala
385                 390                 395                 400 
Gly Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Met Ala Cys Ala
                405                 410                 415     
Ala Ala Ser Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro
            420                 425                 430         
Thr Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ala Val Leu Val Ala
        435                 440                 445             
Trp Glu Arg Pro Glu Met His Ser Glu Gln Ile Ile Gly Phe Ser Leu
    450                 455                 460                 
His Tyr Gln Lys Ala Arg Gly Met Asp Asn Val Glu Tyr Gln Phe Ala
465                 470                 475                 480 
Val Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn
                485                 490                 495     
Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser
            500                 505                 510         
Arg Thr Ser Thr Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser
        515                 520                 525             
Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg
    530                 535                 540                 
Val Ala Trp Leu Pro Leu Pro Pro Ser Leu Ser Asn Gly Gln Val Val
545                 550                 555                 560 
Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Ile Phe Ser
                565                 570                 575     
Thr Glu Val Arg Gly Asn Glu Thr Gln Leu Met Leu Asn Ser Leu Gln
            580                 585                 590         
Pro Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Ala Ala Gly
        595                 600                 605             
Phe Gly Ala Pro Ser Gln Trp Met His His Arg Thr Pro Ser Met His
    610                 615                 620                 
Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Gln Ala
625                 630                 635                 640 
Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr
                645                 650                 655     
Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala Glu Glu
            660                 665                 670         
Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln Ala Trp
        675                 680                 685             
Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu
    690                 695                 700                 
Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe
705                 710                 715                 720 
Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu
                725                 730                 735     
Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro Leu Pro
            740                 745                 750         
Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu
        755                 760                 765             
Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr
    770                 775                 780                 
Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr
785                 790                 795                 800 
Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe
                805                 810                 815     
Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly
            820                 825                 830         
Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser
        835                 840                 845             
Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val
    850                 855                 860                 
Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu
865                 870                 875                 880 
Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His Gln Trp
                885                 890                 895     
Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val His Gly
            900                 905                 910         
Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu
        915                 920                 925             
Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln
    930                 935                 940                 
Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Val Thr
945                 950                 955         


<210> 6
<211> 931
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (25-955), without signal peptide.

<400> 6
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
                405                 410                 415     
Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
            420                 425                 430         
Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
        435                 440                 445             
Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
    450                 455                 460                 
Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
465                 470                 475                 480 
Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
                485                 490                 495     
His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
            500                 505                 510         
Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
        515                 520                 525             
Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
    530                 535                 540                 
Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
545                 550                 555                 560 
Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
                565                 570                 575     
Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
            580                 585                 590         
His His Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala
        595                 600                 605             
Pro Ala Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser
    610                 615                 620                 
Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr
625                 630                 635                 640 
Trp Arg Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro
                645                 650                 655     
Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys
            660                 665                 670         
Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu
        675                 680                 685             
Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala
    690                 695                 700                 
Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro
705                 710                 715                 720 
Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser
                725                 730                 735     
Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr
            740                 745                 750         
Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu
        755                 760                 765             
Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile
    770                 775                 780                 
Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln
785                 790                 795                 800 
Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg
                805                 810                 815     
Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu
            820                 825                 830         
Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr
        835                 840                 845             
Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn
    850                 855                 860                 
His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn
865                 870                 875                 880 
Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe
                885                 890                 895     
Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg
            900                 905                 910         
Leu Gln Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp
        915                 920                 925             
Met His Ser
    930     


<210> 7
<211> 402
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (25-426), without signal peptide.

<400> 7
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu
        


<210> 8
<211> 596
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (25-620), without signal peptide.

<400> 8
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
                405                 410                 415     
Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
            420                 425                 430         
Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
        435                 440                 445             
Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
    450                 455                 460                 
Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
465                 470                 475                 480 
Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
                485                 490                 495     
His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
            500                 505                 510         
Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
        515                 520                 525             
Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
    530                 535                 540                 
Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
545                 550                 555                 560 
Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
                565                 570                 575     
Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
            580                 585                 590         
His His Arg Thr
        595     


<210> 9
<211> 529
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (427-955).

<400> 9
Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu Ser Ser
 1               5                  10                  15      
Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser Glu Gln
            20                  25                  30          
Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met Asp Asn
        35                  40                  45              
Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu Gln Val
    50                  55                  60                  
Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr
65                  70                  75                  80  
Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val His Thr
                85                  90                  95      
Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro
            100                 105                 110         
Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro Ser Leu
        115                 120                 125             
Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys
    130                 135                 140                 
Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr Gln Leu
145                 150                 155                 160 
Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg Ile Ser
                165                 170                 175     
Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met His His
            180                 185                 190         
Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala Pro Ala
        195                 200                 205             
Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser Trp Gln
    210                 215                 220                 
Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg
225                 230                 235                 240 
Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly
                245                 250                 255     
Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys Lys Lys
            260                 265                 270         
Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu
        275                 280                 285             
Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala Ala Val
    290                 295                 300                 
Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro Ile Gln
305                 310                 315                 320 
Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser Asn Ser
                325                 330                 335     
Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr Thr Val
            340                 345                 350         
Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu Arg Asn
        355                 360                 365             
Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile
    370                 375                 380                 
Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln Ser His
385                 390                 395                 400 
Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg Ser Thr
                405                 410                 415     
Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro
            420                 425                 430         
Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr Glu Pro
        435                 440                 445             
Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr
    450                 455                 460                 
Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe
465                 470                 475                 480 
Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys
                485                 490                 495     
Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg Leu Gln
            500                 505                 510         
Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp Met His
        515                 520                 525             
Ser
    


<210> 10
<211> 333
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (623-955).

<400> 10
Met His Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val
 1               5                  10                  15      
Gln Ala Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His
            20                  25                  30          
Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala
        35                  40                  45              
Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln
    50                  55                  60                  
Ala Trp Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr
65                  70                  75                  80  
Glu Leu Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val
                85                  90                  95      
Ala Phe Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys
            100                 105                 110         
Thr Glu Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro
        115                 120                 125             
Leu Pro Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile
    130                 135                 140                 
Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn
145                 150                 155                 160 
Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val
                165                 170                 175     
Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys
            180                 185                 190         
Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met
        195                 200                 205             
Asp Gly Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg
    210                 215                 220                 
Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser
225                 230                 235                 240 
Thr Val Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile
                245                 250                 255     
Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His
            260                 265                 270         
Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val
        275                 280                 285             
His Gly Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg
    290                 295                 300                 
Thr Glu Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr
305                 310                 315                 320 
Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser
                325                 330             


<210> 11
<211> 956
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse NOPE extracellular domain (ECD) (1-956),
      with signal peptide.

<400> 11
Met Ala Arg Ala Asp Thr Gly Arg Gly Leu Leu Val Leu Thr Phe Cys
 1               5                  10                  15      
Leu Leu Ser Ala Arg Gly Glu Leu Pro Leu Pro Gln Glu Thr Thr Val
            20                  25                  30          
Lys Leu Ser Cys Asp Glu Gly Pro Leu Gln Val Ile Leu Gly Pro Glu
        35                  40                  45              
Gln Ala Val Val Leu Asp Cys Thr Leu Gly Ala Thr Ala Ala Gly Pro
    50                  55                  60                  
Pro Thr Arg Val Thr Trp Ser Lys Asp Gly Asp Thr Val Leu Glu His
65                  70                  75                  80  
Glu Asn Leu His Leu Leu Pro Asn Gly Ser Leu Trp Leu Ser Ser Pro
                85                  90                  95      
Leu Glu Gln Glu Asp Ser Asp Asp Glu Glu Ala Leu Arg Ile Trp Lys
            100                 105                 110         
Val Thr Glu Gly Ser Tyr Ser Cys Leu Ala His Ser Pro Leu Gly Val
        115                 120                 125             
Val Ala Ser Gln Val Ala Val Val Lys Leu Ala Thr Leu Glu Asp Phe
    130                 135                 140                 
Ser Leu His Pro Glu Ser Gln Ile Val Glu Glu Asn Gly Thr Ala Arg
145                 150                 155                 160 
Phe Glu Cys His Thr Lys Gly Leu Pro Ala Pro Ile Ile Thr Trp Glu
                165                 170                 175     
Lys Asp Gln Val Thr Val Pro Glu Glu Ser Arg Leu Ile Thr Leu Pro
            180                 185                 190         
Asn Gly Val Leu Gln Ile Leu Asp Val Gln Asp Ser Asp Ala Gly Ser
        195                 200                 205             
Tyr Arg Cys Val Ala Thr Asn Ser Ala Arg Gln Arg Phe Ser Gln Glu
    210                 215                 220                 
Ala Ser Leu Thr Val Ala Leu Arg Gly Ser Leu Glu Ala Thr Arg Gly
225                 230                 235                 240 
Gln Asp Val Val Ile Val Ala Ala Pro Glu Asn Thr Thr Val Val Ser
                245                 250                 255     
Gly Gln Ser Val Val Met Glu Cys Val Ala Ser Ala Asp Pro Thr Pro
            260                 265                 270         
Phe Val Ser Trp Val Arg Gln Asp Gly Lys Pro Ile Ser Thr Asp Val
        275                 280                 285             
Ile Val Leu Gly Arg Thr Asn Leu Leu Ile Ala Ser Ala Gln Pro Arg
    290                 295                 300                 
His Ser Gly Val Tyr Val Cys Arg Ala Asn Lys Pro Arg Thr Arg Asp
305                 310                 315                 320 
Phe Ala Thr Ala Ala Ala Glu Leu Arg Val Leu Ala Ala Pro Ala Ile
                325                 330                 335     
Ser Gln Ala Pro Glu Ala Leu Ser Arg Thr Arg Ala Ser Thr Ala Arg
            340                 345                 350         
Phe Val Cys Arg Ala Ser Gly Glu Pro Arg Pro Ala Leu His Trp Leu
        355                 360                 365             
His Asp Gly Ile Pro Leu Arg Pro Asn Gly Arg Val Lys Val Gln Gly
    370                 375                 380                 
Gly Gly Gly Ser Leu Val Ile Thr Gln Ile Gly Leu Gln Asp Ala Gly
385                 390                 395                 400 
Tyr Tyr Gln Cys Val Ala Glu Asn Ser Ala Gly Thr Ala Cys Ala Ala
                405                 410                 415     
Ala Pro Leu Ala Val Val Val Arg Glu Gly Leu Pro Ser Ala Pro Thr
            420                 425                 430         
Arg Val Thr Ala Thr Pro Leu Ser Ser Ser Ser Val Leu Val Ala Trp
        435                 440                 445             
Glu Arg Pro Glu Leu His Ser Glu Gln Ile Ile Gly Phe Ser Leu His
    450                 455                 460                 
Tyr Gln Lys Ala Arg Gly Val Asp Asn Val Glu Tyr Gln Phe Ala Val
465                 470                 475                 480 
Asn Asn Asp Thr Thr Glu Leu Gln Val Arg Asp Leu Glu Pro Asn Thr
                485                 490                 495     
Asp Tyr Glu Phe Tyr Val Val Ala Tyr Ser Gln Leu Gly Ala Ser Arg
            500                 505                 510         
Thr Ser Ser Pro Ala Leu Val His Thr Leu Asp Asp Val Pro Ser Ala
        515                 520                 525             
Ala Pro Gln Leu Thr Leu Ser Ser Pro Asn Pro Ser Asp Ile Arg Val
    530                 535                 540                 
Ala Trp Leu Pro Leu Pro Ser Ser Leu Ser Asn Gly Gln Val Leu Lys
545                 550                 555                 560 
Tyr Lys Ile Glu Tyr Gly Leu Gly Lys Glu Asp Gln Val Phe Ser Thr
                565                 570                 575     
Glu Val Pro Gly Asn Glu Thr Gln Leu Thr Leu Asn Ser Leu Gln Pro
            580                 585                 590         
Asn Lys Val Tyr Arg Val Arg Ile Ser Ala Gly Thr Gly Ala Gly Tyr
        595                 600                 605             
Gly Val Pro Ser Gln Trp Met Gln His Arg Thr Pro Gly Val His Asn
    610                 615                 620                 
Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Arg Ala Lys
625                 630                 635                 640 
Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro Thr Gln
                645                 650                 655     
Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Thr Glu Glu Glu
            660                 665                 670         
Ala Asp Gly Asp Arg Pro Pro Gly Gly Arg Gly Asp Gln Ala Trp Asp
        675                 680                 685             
Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu Leu Thr
    690                 695                 700                 
Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala Phe Asn
705                 710                 715                 720 
Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr Glu Lys
                725                 730                 735     
Ala Pro Thr Pro Asp Leu Pro Ile Gln Arg Gly Pro Pro Leu Pro Pro
            740                 745                 750         
Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp Leu Arg
        755                 760                 765             
Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr Thr Val
    770                 775                 780                 
Arg Phe Gly Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr Tyr Tyr
785                 790                 795                 800 
Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro Phe Thr
                805                 810                 815     
Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp Gly Pro
            820                 825                 830         
Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro Ser Thr
        835                 840                 845             
Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr Val Arg
    850                 855                 860                 
Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val Glu Tyr
865                 870                 875                 880 
Leu Ile Leu Tyr Ser Asn Asn His Thr Gln Pro Glu His Gln Trp Thr
                885                 890                 895     
Leu Leu Thr Thr Glu Gly Asn Ile Phe Ser Ala Glu Val His Gly Leu
            900                 905                 910         
Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr Glu Val
        915                 920                 925             
Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu Gln Lys
    930                 935                 940                 
Thr Phe Ser Asp Ser Leu Asp Val His Ala Val Thr
945                 950                 955     


<210> 12
<211> 934
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse NOPE ECD (23-956), without signal peptide.

<400> 12
Glu Leu Pro Leu Pro Gln Glu Thr Thr Val Lys Leu Ser Cys Asp Glu
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Val Val Leu Asp
            20                  25                  30          
Cys Thr Leu Gly Ala Thr Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Val Leu Glu His Glu Asn Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Ser Pro Leu Glu Gln Glu Asp Ser
65                  70                  75                  80  
Asp Asp Glu Glu Ala Leu Arg Ile Trp Lys Val Thr Glu Gly Ser Tyr
                85                  90                  95      
Ser Cys Leu Ala His Ser Pro Leu Gly Val Val Ala Ser Gln Val Ala
            100                 105                 110         
Val Val Lys Leu Ala Thr Leu Glu Asp Phe Ser Leu His Pro Glu Ser
        115                 120                 125             
Gln Ile Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Thr Lys
    130                 135                 140                 
Gly Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Val
145                 150                 155                 160 
Pro Glu Glu Ser Arg Leu Ile Thr Leu Pro Asn Gly Val Leu Gln Ile
                165                 170                 175     
Leu Asp Val Gln Asp Ser Asp Ala Gly Ser Tyr Arg Cys Val Ala Thr
            180                 185                 190         
Asn Ser Ala Arg Gln Arg Phe Ser Gln Glu Ala Ser Leu Thr Val Ala
        195                 200                 205             
Leu Arg Gly Ser Leu Glu Ala Thr Arg Gly Gln Asp Val Val Ile Val
    210                 215                 220                 
Ala Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met
225                 230                 235                 240 
Glu Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg
                245                 250                 255     
Gln Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr
            260                 265                 270         
Asn Leu Leu Ile Ala Ser Ala Gln Pro Arg His Ser Gly Val Tyr Val
        275                 280                 285             
Cys Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala
    290                 295                 300                 
Glu Leu Arg Val Leu Ala Ala Pro Ala Ile Ser Gln Ala Pro Glu Ala
305                 310                 315                 320 
Leu Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser
                325                 330                 335     
Gly Glu Pro Arg Pro Ala Leu His Trp Leu His Asp Gly Ile Pro Leu
            340                 345                 350         
Arg Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val
        355                 360                 365             
Ile Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala
    370                 375                 380                 
Glu Asn Ser Ala Gly Thr Ala Cys Ala Ala Ala Pro Leu Ala Val Val
385                 390                 395                 400 
Val Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro
                405                 410                 415     
Leu Ser Ser Ser Ser Val Leu Val Ala Trp Glu Arg Pro Glu Leu His
            420                 425                 430         
Ser Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly
        435                 440                 445             
Val Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu
    450                 455                 460                 
Leu Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val
465                 470                 475                 480 
Val Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Ser Pro Ala Leu
                485                 490                 495     
Val His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Thr Leu
            500                 505                 510         
Ser Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro
        515                 520                 525             
Ser Ser Leu Ser Asn Gly Gln Val Leu Lys Tyr Lys Ile Glu Tyr Gly
    530                 535                 540                 
Leu Gly Lys Glu Asp Gln Val Phe Ser Thr Glu Val Pro Gly Asn Glu
545                 550                 555                 560 
Thr Gln Leu Thr Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val
                565                 570                 575     
Arg Ile Ser Ala Gly Thr Gly Ala Gly Tyr Gly Val Pro Ser Gln Trp
            580                 585                 590         
Met Gln His Arg Thr Pro Gly Val His Asn Gln Ser His Val Pro Phe
        595                 600                 605             
Ala Pro Ala Glu Leu Lys Val Arg Ala Lys Met Glu Ser Leu Val Val
    610                 615                 620                 
Ser Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu
625                 630                 635                 640 
Tyr Trp Arg Glu Val Gly Thr Glu Glu Glu Ala Asp Gly Asp Arg Pro
                645                 650                 655     
Pro Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu
            660                 665                 670         
Lys Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg
        675                 680                 685             
Leu Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr
    690                 695                 700                 
Ala Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Thr Pro Asp Leu
705                 710                 715                 720 
Pro Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu
                725                 730                 735     
Ser Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe
            740                 745                 750         
Thr Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Gly Pro Trp Gly
        755                 760                 765             
Leu Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp
    770                 775                 780                 
Ile Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val
785                 790                 795                 800 
Gln Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu
                805                 810                 815     
Arg Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg
            820                 825                 830         
Leu Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro
        835                 840                 845             
Thr Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Asn
    850                 855                 860                 
Asn His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Glu Gly
865                 870                 875                 880 
Asn Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr
                885                 890                 895     
Phe Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser
            900                 905                 910         
Arg Leu Gln Asp Val Ile Thr Leu Gln Lys Thr Phe Ser Asp Ser Leu
        915                 920                 925             
Asp Val His Ala Val Thr
    930                 


<210> 13
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse NOPE ECD (23-619), without signal peptide.

<400> 13
Glu Leu Pro Leu Pro Gln Glu Thr Thr Val Lys Leu Ser Cys Asp Glu
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Val Val Leu Asp
            20                  25                  30          
Cys Thr Leu Gly Ala Thr Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Val Leu Glu His Glu Asn Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Ser Pro Leu Glu Gln Glu Asp Ser
65                  70                  75                  80  
Asp Asp Glu Glu Ala Leu Arg Ile Trp Lys Val Thr Glu Gly Ser Tyr
                85                  90                  95      
Ser Cys Leu Ala His Ser Pro Leu Gly Val Val Ala Ser Gln Val Ala
            100                 105                 110         
Val Val Lys Leu Ala Thr Leu Glu Asp Phe Ser Leu His Pro Glu Ser
        115                 120                 125             
Gln Ile Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Thr Lys
    130                 135                 140                 
Gly Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Val
145                 150                 155                 160 
Pro Glu Glu Ser Arg Leu Ile Thr Leu Pro Asn Gly Val Leu Gln Ile
                165                 170                 175     
Leu Asp Val Gln Asp Ser Asp Ala Gly Ser Tyr Arg Cys Val Ala Thr
            180                 185                 190         
Asn Ser Ala Arg Gln Arg Phe Ser Gln Glu Ala Ser Leu Thr Val Ala
        195                 200                 205             
Leu Arg Gly Ser Leu Glu Ala Thr Arg Gly Gln Asp Val Val Ile Val
    210                 215                 220                 
Ala Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met
225                 230                 235                 240 
Glu Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg
                245                 250                 255     
Gln Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr
            260                 265                 270         
Asn Leu Leu Ile Ala Ser Ala Gln Pro Arg His Ser Gly Val Tyr Val
        275                 280                 285             
Cys Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala
    290                 295                 300                 
Glu Leu Arg Val Leu Ala Ala Pro Ala Ile Ser Gln Ala Pro Glu Ala
305                 310                 315                 320 
Leu Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser
                325                 330                 335     
Gly Glu Pro Arg Pro Ala Leu His Trp Leu His Asp Gly Ile Pro Leu
            340                 345                 350         
Arg Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val
        355                 360                 365             
Ile Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala
    370                 375                 380                 
Glu Asn Ser Ala Gly Thr Ala Cys Ala Ala Ala Pro Leu Ala Val Val
385                 390                 395                 400 
Val Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro
                405                 410                 415     
Leu Ser Ser Ser Ser Val Leu Val Ala Trp Glu Arg Pro Glu Leu His
            420                 425                 430         
Ser Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly
        435                 440                 445             
Val Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu
    450                 455                 460                 
Leu Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val
465                 470                 475                 480 
Val Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Ser Pro Ala Leu
                485                 490                 495     
Val His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Thr Leu
            500                 505                 510         
Ser Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro
        515                 520                 525             
Ser Ser Leu Ser Asn Gly Gln Val Leu Lys Tyr Lys Ile Glu Tyr Gly
    530                 535                 540                 
Leu Gly Lys Glu Asp Gln Val Phe Ser Thr Glu Val Pro Gly Asn Glu
545                 550                 555                 560 
Thr Gln Leu Thr Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val
                565                 570                 575     
Arg Ile Ser Ala Gly Thr Gly Ala Gly Tyr Gly Val Pro Ser Gln Trp
            580                 585                 590         
Met Gln His Arg Thr
        595         


<210> 14
<211> 334
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse NOPE ECD (623-956), without signal peptide.

<400> 14
His Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val Arg
 1               5                  10                  15      
Ala Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His Pro
            20                  25                  30          
Thr Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Thr Glu
        35                  40                  45              
Glu Glu Ala Asp Gly Asp Arg Pro Pro Gly Gly Arg Gly Asp Gln Ala
    50                  55                  60                  
Trp Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr Glu
65                  70                  75                  80  
Leu Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val Ala
                85                  90                  95      
Phe Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys Thr
            100                 105                 110         
Glu Lys Ala Pro Thr Pro Asp Leu Pro Ile Gln Arg Gly Pro Pro Leu
        115                 120                 125             
Pro Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile Trp
    130                 135                 140                 
Leu Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn Tyr
145                 150                 155                 160 
Thr Val Arg Phe Gly Pro Trp Gly Leu Arg Asn Ala Ser Leu Val Thr
                165                 170                 175     
Tyr Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys Pro
            180                 185                 190         
Phe Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met Asp
        195                 200                 205             
Gly Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg Pro
    210                 215                 220                 
Ser Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser Thr
225                 230                 235                 240 
Val Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile Val
                245                 250                 255     
Glu Tyr Leu Ile Leu Tyr Ser Asn Asn His Thr Gln Pro Glu His Gln
            260                 265                 270         
Trp Thr Leu Leu Thr Thr Glu Gly Asn Ile Phe Ser Ala Glu Val His
        275                 280                 285             
Gly Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg Thr
    290                 295                 300                 
Glu Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr Leu
305                 310                 315                 320 
Gln Lys Thr Phe Ser Asp Ser Leu Asp Val His Ala Val Thr
                325                 330                 


<210> 15
<211> 1165
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (25-955)-Fc fusion molecule,
      without signal peptide.

<400> 15
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
                405                 410                 415     
Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
            420                 425                 430         
Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
        435                 440                 445             
Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
    450                 455                 460                 
Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
465                 470                 475                 480 
Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
                485                 490                 495     
His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
            500                 505                 510         
Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
        515                 520                 525             
Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
    530                 535                 540                 
Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
545                 550                 555                 560 
Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
                565                 570                 575     
Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
            580                 585                 590         
His His Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala
        595                 600                 605             
Pro Ala Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser
    610                 615                 620                 
Trp Gln Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr
625                 630                 635                 640 
Trp Arg Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro
                645                 650                 655     
Gly Gly Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys
            660                 665                 670         
Lys Lys Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu
        675                 680                 685             
Tyr Glu Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala
    690                 695                 700                 
Ala Val Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro
705                 710                 715                 720 
Ile Gln Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser
                725                 730                 735     
Asn Ser Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr
            740                 745                 750         
Thr Val Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu
        755                 760                 765             
Arg Asn Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile
    770                 775                 780                 
Leu Ile Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln
785                 790                 795                 800 
Ser His Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg
                805                 810                 815     
Ser Thr Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu
            820                 825                 830         
Ser Pro Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr
        835                 840                 845             
Glu Pro Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn
    850                 855                 860                 
His Thr Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn
865                 870                 875                 880 
Ile Phe Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe
                885                 890                 895     
Phe Lys Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg
            900                 905                 910         
Leu Gln Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp
        915                 920                 925             
Met His Ser Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys
    930                 935                 940                 
Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu
945                 950                 955                 960 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                965                 970                 975     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
            980                 985                 990         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        995                 1000                1005            
Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    1010                1015                1020                
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
1025                1030                1035               1040 
Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys
                1045                1050                1055    
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            1060                1065                1070        
Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        1075                1080                1085            
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    1090                1095                1100                
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
1105                1110                1115               1120 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln
                1125                1130                1135    
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            1140                1145                1150        
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        1155                1160                1165


<210> 16
<211> 636
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (25-426)-Fc fusion molecule,
      without signal peptide.

<400> 16
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro
                405                 410                 415     
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe
            420                 425                 430         
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
        435                 440                 445             
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
    450                 455                 460                 
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
465                 470                 475                 480 
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
                485                 490                 495     
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
            500                 505                 510         
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala
        515                 520                 525             
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg
    530                 535                 540                 
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
545                 550                 555                 560 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
                565                 570                 575     
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
            580                 585                 590         
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln
        595                 600                 605             
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
    610                 615                 620                 
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
625                 630                 635     


<210> 17
<211> 830
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (25-620)-Fc fusion molecule,
      without signal peptide.

<400> 17
Glu Leu Leu Leu Pro Gln Glu Thr Thr Val Glu Leu Ser Cys Gly Val
 1               5                  10                  15      
Gly Pro Leu Gln Val Ile Leu Gly Pro Glu Gln Ala Ala Val Leu Asn
            20                  25                  30          
Cys Ser Leu Gly Ala Ala Ala Ala Gly Pro Pro Thr Arg Val Thr Trp
        35                  40                  45              
Ser Lys Asp Gly Asp Thr Leu Leu Glu His Asp His Leu His Leu Leu
    50                  55                  60                  
Pro Asn Gly Ser Leu Trp Leu Ser Gln Pro Leu Ala Pro Asn Gly Ser
65                  70                  75                  80  
Asp Glu Ser Val Pro Glu Ala Val Gly Val Ile Glu Gly Asn Tyr Ser
                85                  90                  95      
Cys Leu Ala His Gly Pro Leu Gly Val Leu Ala Ser Gln Thr Ala Val
            100                 105                 110         
Val Lys Leu Ala Thr Leu Ala Asp Phe Ser Leu His Pro Glu Ser Gln
        115                 120                 125             
Thr Val Glu Glu Asn Gly Thr Ala Arg Phe Glu Cys His Ile Glu Gly
    130                 135                 140                 
Leu Pro Ala Pro Ile Ile Thr Trp Glu Lys Asp Gln Val Thr Leu Pro
145                 150                 155                 160 
Glu Glu Pro Arg Leu Ile Val Leu Pro Asn Gly Val Leu Gln Ile Leu
                165                 170                 175     
Asp Val Gln Glu Ser Asp Ala Gly Pro Tyr Arg Cys Val Ala Thr Asn
            180                 185                 190         
Ser Ala Arg Gln His Phe Ser Gln Glu Ala Leu Leu Ser Val Ala His
        195                 200                 205             
Arg Gly Ser Leu Ala Ser Thr Arg Gly Gln Asp Val Val Ile Val Ala
    210                 215                 220                 
Ala Pro Glu Asn Thr Thr Val Val Ser Gly Gln Ser Val Val Met Glu
225                 230                 235                 240 
Cys Val Ala Ser Ala Asp Pro Thr Pro Phe Val Ser Trp Val Arg Gln
                245                 250                 255     
Asp Gly Lys Pro Ile Ser Thr Asp Val Ile Val Leu Gly Arg Thr Asn
            260                 265                 270         
Leu Leu Ile Ala Asn Ala Gln Pro Trp His Ser Gly Val Tyr Val Cys
        275                 280                 285             
Arg Ala Asn Lys Pro Arg Thr Arg Asp Phe Ala Thr Ala Ala Ala Glu
    290                 295                 300                 
Leu Arg Val Leu Ala Ala Pro Ala Ile Thr Gln Ala Pro Glu Ala Leu
305                 310                 315                 320 
Ser Arg Thr Arg Ala Ser Thr Ala Arg Phe Val Cys Arg Ala Ser Gly
                325                 330                 335     
Glu Pro Arg Pro Ala Leu Arg Trp Leu His Asn Gly Ala Pro Leu Arg
            340                 345                 350         
Pro Asn Gly Arg Val Lys Val Gln Gly Gly Gly Gly Ser Leu Val Ile
        355                 360                 365             
Thr Gln Ile Gly Leu Gln Asp Ala Gly Tyr Tyr Gln Cys Val Ala Glu
    370                 375                 380                 
Asn Ser Ala Gly Met Ala Cys Ala Ala Ala Ser Leu Ala Val Val Val
385                 390                 395                 400 
Arg Glu Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu
                405                 410                 415     
Ser Ser Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser
            420                 425                 430         
Glu Gln Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met
        435                 440                 445             
Asp Asn Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu
    450                 455                 460                 
Gln Val Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val
465                 470                 475                 480 
Ala Tyr Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val
                485                 490                 495     
His Thr Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser
            500                 505                 510         
Ser Pro Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro
        515                 520                 525             
Ser Leu Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu
    530                 535                 540                 
Gly Lys Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr
545                 550                 555                 560 
Gln Leu Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg
                565                 570                 575     
Ile Ser Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met
            580                 585                 590         
His His Arg Thr Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr
        595                 600                 605             
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
    610                 615                 620                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
625                 630                 635                 640 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
                645                 650                 655     
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
            660                 665                 670         
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
        675                 680                 685             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
    690                 695                 700                 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
705                 710                 715                 720 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                725                 730                 735     
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
            740                 745                 750         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
        755                 760                 765             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
    770                 775                 780                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
785                 790                 795                 800 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
                805                 810                 815     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            820                 825                 830 


<210> 18
<211> 763
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (427-955)-Fc fusion molecule,
      without signal peptide.

<400> 18
Gly Leu Pro Ser Ala Pro Thr Arg Val Thr Ala Thr Pro Leu Ser Ser
 1               5                  10                  15      
Ser Ala Val Leu Val Ala Trp Glu Arg Pro Glu Met His Ser Glu Gln
            20                  25                  30          
Ile Ile Gly Phe Ser Leu His Tyr Gln Lys Ala Arg Gly Met Asp Asn
        35                  40                  45              
Val Glu Tyr Gln Phe Ala Val Asn Asn Asp Thr Thr Glu Leu Gln Val
    50                  55                  60                  
Arg Asp Leu Glu Pro Asn Thr Asp Tyr Glu Phe Tyr Val Val Ala Tyr
65                  70                  75                  80  
Ser Gln Leu Gly Ala Ser Arg Thr Ser Thr Pro Ala Leu Val His Thr
                85                  90                  95      
Leu Asp Asp Val Pro Ser Ala Ala Pro Gln Leu Ser Leu Ser Ser Pro
            100                 105                 110         
Asn Pro Ser Asp Ile Arg Val Ala Trp Leu Pro Leu Pro Pro Ser Leu
        115                 120                 125             
Ser Asn Gly Gln Val Val Lys Tyr Lys Ile Glu Tyr Gly Leu Gly Lys
    130                 135                 140                 
Glu Asp Gln Ile Phe Ser Thr Glu Val Arg Gly Asn Glu Thr Gln Leu
145                 150                 155                 160 
Met Leu Asn Ser Leu Gln Pro Asn Lys Val Tyr Arg Val Arg Ile Ser
                165                 170                 175     
Ala Gly Thr Ala Ala Gly Phe Gly Ala Pro Ser Gln Trp Met His His
            180                 185                 190         
Arg Thr Pro Ser Met His Asn Gln Ser His Val Pro Phe Ala Pro Ala
        195                 200                 205             
Glu Leu Lys Val Gln Ala Lys Met Glu Ser Leu Val Val Ser Trp Gln
    210                 215                 220                 
Pro Pro Pro His Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg
225                 230                 235                 240 
Glu Val Gly Ala Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly
                245                 250                 255     
Arg Gly Asp Gln Ala Trp Asp Val Gly Pro Val Arg Leu Lys Lys Lys
            260                 265                 270         
Val Lys Gln Tyr Glu Leu Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu
        275                 280                 285             
Val Lys Leu Val Ala Phe Asn Lys His Glu Asp Gly Tyr Ala Ala Val
    290                 295                 300                 
Trp Lys Gly Lys Thr Glu Lys Ala Pro Ala Pro Asp Met Pro Ile Gln
305                 310                 315                 320 
Arg Gly Pro Pro Leu Pro Pro Ala His Val His Ala Glu Ser Asn Ser
                325                 330                 335     
Ser Thr Ser Ile Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr Thr Val
            340                 345                 350         
Lys Ile Val Asn Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu Arg Asn
        355                 360                 365             
Ala Ser Leu Val Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile
    370                 375                 380                 
Gly Gly Leu Lys Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln Ser His
385                 390                 395                 400 
Gly Val Asp Met Asp Gly Pro Phe Gly Ser Val Val Glu Arg Ser Thr
                405                 410                 415     
Leu Pro Asp Arg Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro
            420                 425                 430         
Leu Thr Pro Ser Thr Val Arg Leu His Trp Cys Pro Pro Thr Glu Pro
        435                 440                 445             
Asn Gly Glu Ile Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr
    450                 455                 460                 
Gln Pro Glu His Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe
465                 470                 475                 480 
Ser Ala Glu Val His Gly Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys
                485                 490                 495     
Met Gly Ala Arg Thr Glu Val Gly Pro Gly Pro Phe Ser Arg Leu Gln
            500                 505                 510         
Asp Val Ile Thr Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp Met His
        515                 520                 525             
Ser Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro
    530                 535                 540                 
Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
545                 550                 555                 560 
Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                565                 570                 575     
Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn
            580                 585                 590         
Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg
        595                 600                 605             
Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val
    610                 615                 620                 
Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser
625                 630                 635                 640 
Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
                645                 650                 655     
Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp
            660                 665                 670         
Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe
        675                 680                 685             
Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu
    690                 695                 700                 
Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe
705                 710                 715                 720 
Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                725                 730                 735     
Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr
            740                 745                 750         
Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        755                 760             


<210> 19
<211> 567
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human NOPE ECD (623-955)-Fc fusion molecule,
      without signal peptide.

<400> 19
Met His Asn Gln Ser His Val Pro Phe Ala Pro Ala Glu Leu Lys Val
 1               5                  10                  15      
Gln Ala Lys Met Glu Ser Leu Val Val Ser Trp Gln Pro Pro Pro His
            20                  25                  30          
Pro Thr Gln Ile Ser Gly Tyr Lys Leu Tyr Trp Arg Glu Val Gly Ala
        35                  40                  45              
Glu Glu Glu Ala Asn Gly Asp Arg Leu Pro Gly Gly Arg Gly Asp Gln
    50                  55                  60                  
Ala Trp Asp Val Gly Pro Val Arg Leu Lys Lys Lys Val Lys Gln Tyr
65                  70                  75                  80  
Glu Leu Thr Gln Leu Val Pro Gly Arg Leu Tyr Glu Val Lys Leu Val
                85                  90                  95      
Ala Phe Asn Lys His Glu Asp Gly Tyr Ala Ala Val Trp Lys Gly Lys
            100                 105                 110         
Thr Glu Lys Ala Pro Ala Pro Asp Met Pro Ile Gln Arg Gly Pro Pro
        115                 120                 125             
Leu Pro Pro Ala His Val His Ala Glu Ser Asn Ser Ser Thr Ser Ile
    130                 135                 140                 
Trp Leu Arg Trp Lys Lys Pro Asp Phe Thr Thr Val Lys Ile Val Asn
145                 150                 155                 160 
Tyr Thr Val Arg Phe Ser Pro Trp Gly Leu Arg Asn Ala Ser Leu Val
                165                 170                 175     
Thr Tyr Tyr Thr Ser Ser Gly Glu Asp Ile Leu Ile Gly Gly Leu Lys
            180                 185                 190         
Pro Phe Thr Lys Tyr Glu Phe Ala Val Gln Ser His Gly Val Asp Met
        195                 200                 205             
Asp Gly Pro Phe Gly Ser Val Val Glu Arg Ser Thr Leu Pro Asp Arg
    210                 215                 220                 
Pro Ser Thr Pro Pro Ser Asp Leu Arg Leu Ser Pro Leu Thr Pro Ser
225                 230                 235                 240 
Thr Val Arg Leu His Trp Cys Pro Pro Thr Glu Pro Asn Gly Glu Ile
                245                 250                 255     
Val Glu Tyr Leu Ile Leu Tyr Ser Ser Asn His Thr Gln Pro Glu His
            260                 265                 270         
Gln Trp Thr Leu Leu Thr Thr Gln Gly Asn Ile Phe Ser Ala Glu Val
        275                 280                 285             
His Gly Leu Glu Ser Asp Thr Arg Tyr Phe Phe Lys Met Gly Ala Arg
    290                 295                 300                 
Thr Glu Val Gly Pro Gly Pro Phe Ser Arg Leu Gln Asp Val Ile Thr
305                 310                 315                 320 
Leu Gln Glu Lys Leu Ser Asp Ser Leu Asp Met His Ser Gly Ser Glu
                325                 330                 335     
Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
            340                 345                 350         
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        355                 360                 365             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    370                 375                 380                 
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
385                 390                 395                 400 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
                405                 410                 415     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            420                 425                 430         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
        435                 440                 445             
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    450                 455                 460                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
465                 470                 475                 480 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                485                 490                 495     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            500                 505                 510         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        515                 520                 525             
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
    530                 535                 540                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
545                 550                 555                 560 
Leu Ser Leu Ser Pro Gly Lys
                565         


<210> 20
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human myostatin.

<400> 20
Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys
 1               5                  10                  15      
Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile
            20                  25                  30          
Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu
        35                  40                  45              
Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala
    50                  55                  60                  
Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser
65                  70                  75                  80  
Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly
                85                  90                  95      
Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser
            100                 105                 


<210> 21
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human pro-myostatin (with signal sequence).

<400> 21
Met Gln Lys Leu Gln Leu Cys Val Tyr Ile Tyr Leu Phe Met Leu Ile
 1               5                  10                  15      
Val Ala Gly Pro Val Asp Leu Asn Glu Asn Ser Glu Gln Lys Glu Asn
            20                  25                  30          
Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Thr Trp Arg Gln Asn Thr
        35                  40                  45              
Lys Ser Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys Leu
    50                  55                  60                  
Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Val Ile Arg Gln Leu
65                  70                  75                  80  
Leu Pro Lys Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp Val
                85                  90                  95      
Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr His
            100                 105                 110         
Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe Leu
        115                 120                 125             
Met Gln Val Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser Ser
    130                 135                 140                 
Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr Leu
145                 150                 155                 160 
Arg Pro Val Glu Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg Leu
                165                 170                 175     
Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser Leu
            180                 185                 190         
Lys Leu Asp Met Asn Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp Val
        195                 200                 205             
Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu Gly
    210                 215                 220                 
Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val Thr
225                 230                 235                 240 
Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val Lys
                245                 250                 255     
Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp Cys
            260                 265                 270         
Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr Val
        275                 280                 285             
Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg Tyr
    290                 295                 300                 
Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln Lys
305                 310                 315                 320 
Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser Ala
                325                 330                 335     
Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu Tyr
            340                 345                 350         
Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met Val
        355                 360                 365             
Val Asp Arg Cys Gly Cys Ser
    370                 375 


<210> 22
<211> 352
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human pro-myostatin (without signal sequence).

<400> 22
Asn Glu Asn Ser Glu Gln Lys Glu Asn Val Glu Lys Glu Gly Leu Cys
 1               5                  10                  15      
Asn Ala Cys Thr Trp Arg Gln Asn Thr Lys Ser Ser Arg Ile Glu Ala
            20                  25                  30          
Ile Lys Ile Gln Ile Leu Ser Lys Leu Arg Leu Glu Thr Ala Pro Asn
        35                  40                  45              
Ile Ser Lys Asp Val Ile Arg Gln Leu Leu Pro Lys Ala Pro Pro Leu
    50                  55                  60                  
Arg Glu Leu Ile Asp Gln Tyr Asp Val Gln Arg Asp Asp Ser Ser Asp
65                  70                  75                  80  
Gly Ser Leu Glu Asp Asp Asp Tyr His Ala Thr Thr Glu Thr Ile Ile
                85                  90                  95      
Thr Met Pro Thr Glu Ser Asp Phe Leu Met Gln Val Asp Gly Lys Pro
            100                 105                 110         
Lys Cys Cys Phe Phe Lys Phe Ser Ser Lys Ile Gln Tyr Asn Lys Val
        115                 120                 125             
Val Lys Ala Gln Leu Trp Ile Tyr Leu Arg Pro Val Glu Thr Pro Thr
    130                 135                 140                 
Thr Val Phe Val Gln Ile Leu Arg Leu Ile Lys Pro Met Lys Asp Gly
145                 150                 155                 160 
Thr Arg Tyr Thr Gly Ile Arg Ser Leu Lys Leu Asp Met Asn Pro Gly
                165                 170                 175     
Thr Gly Ile Trp Gln Ser Ile Asp Val Lys Thr Val Leu Gln Asn Trp
            180                 185                 190         
Leu Lys Gln Pro Glu Ser Asn Leu Gly Ile Glu Ile Lys Ala Leu Asp
        195                 200                 205             
Glu Asn Gly His Asp Leu Ala Val Thr Phe Pro Gly Pro Gly Glu Asp
    210                 215                 220                 
Gly Leu Asn Pro Phe Leu Glu Val Lys Val Thr Asp Thr Pro Lys Arg
225                 230                 235                 240 
Ser Arg Arg Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser
                245                 250                 255     
Arg Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp
            260                 265                 270         
Asp Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly
        275                 280                 285             
Glu Cys Glu Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val
    290                 295                 300                 
His Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr
305                 310                 315                 320 
Lys Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile
                325                 330                 335     
Ile Tyr Gly Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser
            340                 345                 350         


<210> 23
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse myostatin.

<400> 23
Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys
 1               5                  10                  15      
Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile
            20                  25                  30          
Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu
        35                  40                  45              
Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala
    50                  55                  60                  
Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser
65                  70                  75                  80  
Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly
                85                  90                  95      
Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser
            100                 105                 


<210> 24
<211> 376
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse pro-myostatin (with signal sequence).

<400> 24
Met Met Gln Lys Leu Gln Met Tyr Val Tyr Ile Tyr Leu Phe Met Leu
 1               5                  10                  15      
Ile Ala Ala Gly Pro Val Asp Leu Asn Glu Gly Ser Glu Arg Glu Glu
            20                  25                  30          
Asn Val Glu Lys Glu Gly Leu Cys Asn Ala Cys Ala Trp Arg Gln Asn
        35                  40                  45              
Thr Arg Tyr Ser Arg Ile Glu Ala Ile Lys Ile Gln Ile Leu Ser Lys
    50                  55                  60                  
Leu Arg Leu Glu Thr Ala Pro Asn Ile Ser Lys Asp Ala Ile Arg Gln
65                  70                  75                  80  
Leu Leu Pro Arg Ala Pro Pro Leu Arg Glu Leu Ile Asp Gln Tyr Asp
                85                  90                  95      
Val Gln Arg Asp Asp Ser Ser Asp Gly Ser Leu Glu Asp Asp Asp Tyr
            100                 105                 110         
His Ala Thr Thr Glu Thr Ile Ile Thr Met Pro Thr Glu Ser Asp Phe
        115                 120                 125             
Leu Met Gln Ala Asp Gly Lys Pro Lys Cys Cys Phe Phe Lys Phe Ser
    130                 135                 140                 
Ser Lys Ile Gln Tyr Asn Lys Val Val Lys Ala Gln Leu Trp Ile Tyr
145                 150                 155                 160 
Leu Arg Pro Val Lys Thr Pro Thr Thr Val Phe Val Gln Ile Leu Arg
                165                 170                 175     
Leu Ile Lys Pro Met Lys Asp Gly Thr Arg Tyr Thr Gly Ile Arg Ser
            180                 185                 190         
Leu Lys Leu Asp Met Ser Pro Gly Thr Gly Ile Trp Gln Ser Ile Asp
        195                 200                 205             
Val Lys Thr Val Leu Gln Asn Trp Leu Lys Gln Pro Glu Ser Asn Leu
    210                 215                 220                 
Gly Ile Glu Ile Lys Ala Leu Asp Glu Asn Gly His Asp Leu Ala Val
225                 230                 235                 240 
Thr Phe Pro Gly Pro Gly Glu Asp Gly Leu Asn Pro Phe Leu Glu Val
                245                 250                 255     
Lys Val Thr Asp Thr Pro Lys Arg Ser Arg Arg Asp Phe Gly Leu Asp
            260                 265                 270         
Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys Arg Tyr Pro Leu Thr
        275                 280                 285             
Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile Ile Ala Pro Lys Arg
    290                 295                 300                 
Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu Phe Val Phe Leu Gln
305                 310                 315                 320 
Lys Tyr Pro His Thr His Leu Val His Gln Ala Asn Pro Arg Gly Ser
                325                 330                 335     
Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser Pro Ile Asn Met Leu
            340                 345                 350         
Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly Lys Ile Pro Ala Met
        355                 360                 365             
Val Val Asp Arg Cys Gly Cys Ser
    370                 375     


<210> 25
<211> 351
<212> PRT
<213> Artificial Sequence

<220> 
<223> Mouse pro-myostatin (without signal sequence).

<400> 25
Glu Gly Ser Glu Arg Glu Glu Asn Val Glu Lys Glu Gly Leu Cys Asn
 1               5                  10                  15      
Ala Cys Ala Trp Arg Gln Asn Thr Arg Tyr Ser Arg Ile Glu Ala Ile
            20                  25                  30          
Lys Ile Gln Ile Leu Ser Lys Leu Arg Leu Glu Thr Ala Pro Asn Ile
        35                  40                  45              
Ser Lys Asp Ala Ile Arg Gln Leu Leu Pro Arg Ala Pro Pro Leu Arg
    50                  55                  60                  
Glu Leu Ile Asp Gln Tyr Asp Val Gln Arg Asp Asp Ser Ser Asp Gly
65                  70                  75                  80  
Ser Leu Glu Asp Asp Asp Tyr His Ala Thr Thr Glu Thr Ile Ile Thr
                85                  90                  95      
Met Pro Thr Glu Ser Asp Phe Leu Met Gln Ala Asp Gly Lys Pro Lys
            100                 105                 110         
Cys Cys Phe Phe Lys Phe Ser Ser Lys Ile Gln Tyr Asn Lys Val Val
        115                 120                 125             
Lys Ala Gln Leu Trp Ile Tyr Leu Arg Pro Val Lys Thr Pro Thr Thr
    130                 135                 140                 
Val Phe Val Gln Ile Leu Arg Leu Ile Lys Pro Met Lys Asp Gly Thr
145                 150                 155                 160 
Arg Tyr Thr Gly Ile Arg Ser Leu Lys Leu Asp Met Ser Pro Gly Thr
                165                 170                 175     
Gly Ile Trp Gln Ser Ile Asp Val Lys Thr Val Leu Gln Asn Trp Leu
            180                 185                 190         
Lys Gln Pro Glu Ser Asn Leu Gly Ile Glu Ile Lys Ala Leu Asp Glu
        195                 200                 205             
Asn Gly His Asp Leu Ala Val Thr Phe Pro Gly Pro Gly Glu Asp Gly
    210                 215                 220                 
Leu Asn Pro Phe Leu Glu Val Lys Val Thr Asp Thr Pro Lys Arg Ser
225                 230                 235                 240 
Arg Arg Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg
                245                 250                 255     
Cys Cys Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp
            260                 265                 270         
Trp Ile Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu
        275                 280                 285             
Cys Glu Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His
    290                 295                 300                 
Gln Ala Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys
305                 310                 315                 320 
Met Ser Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile
                325                 330                 335     
Tyr Gly Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser
            340                 345                 350     


<210> 26
<211> 232
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc C237S.

<400> 26
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala
 1               5                  10                  15      
Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65                  70                  75                  80  
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
                165                 170                 175     
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
    210                 215                 220                 
Ser Leu Ser Leu Ser Pro Gly Lys
225                 230         


<210> 27
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Fc #1.

<400> 27
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val
 1               5                  10                  15      
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr
65                  70                  75                  80  
Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Lys
225             


<210> 28
<211> 229
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Fc #2.

<400> 28
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe
 1               5                  10                  15      
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
            20                  25                  30          
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
        35                  40                  45              
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
    50                  55                  60                  
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65                  70                  75                  80  
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
                85                  90                  95      
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
            100                 105                 110         
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
        115                 120                 125             
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
    130                 135                 140                 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145                 150                 155                 160 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                165                 170                 175     
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
            180                 185                 190         
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
        195                 200                 205             
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
    210                 215                 220                 
Leu Ser Leu Gly Lys
225                 

