                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  TREATMENT OF HIPPO PATHWAY MUTANT TUMORS AND METHODS OF 
       IDENTIFYING SUBJECTS AS CANDIDATES FOR TREATMENT

<130>  29539.0631

<150>  62/327,903
<151>  2016-04-26

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  7533
<212>  DNA
<213>  Homo sapiens

<400>  1
gcgacgctca cgaacgatca gagctgcggg cgacgcaacg aagcccggag gccgcaggct       60

gcgcgctccc tcgcagcagc cgggcgggca aaagccccca gtcctcggcc cccgcgcaag      120

cgacgccggg aaatgcccac atccgggaaa cctgcagcgg agtgcggcgg cggcgacact      180

gagtggaagg caaaatggcg gcggcggcgg cggtggcctg gtgttaaggg gagagccagg      240

tcctcacgac ccctgggacg ggccgcgctg gcccgcggca gcccccccgt tcgtctcccc      300

gctctgcccc accagggata cttggggttg ctgggacgga ctctggccgc ctcagcgtcc      360

gccctcaggc ccgtggccgc tgtccaggag ctctgctctc ccctccagag ttaattattt      420

atattgtaaa gaattttaac agtcctgggg acttccttga aggatcattt tcacttttgc      480

tcagaagaaa gctctggatc tatcaaataa agaagtcctt cgtgtgggct acatatatag      540

atgttttcat gaagaggagt gaaaagccag aaggatatag acaaatgagg cctaagacct      600

ttcctgccag taactatact gtcagtagcc ggcaaatgtt acaagaaatt cgggaatccc      660

ttaggaattt atctaaacca tctgatgctg ctaaggctga gcataacatg agtaaaatgt      720

caaccgaaga tcctcgacaa gtcagaaatc cacccaaatt tgggacgcat cataaagcct      780

tgcaggaaat tcgaaactct ctgcttccat ttgcaaatga aacaaattct tctcggagta      840

cttcagaagt taatccacaa atgcttcaag acttgcaagc tgctggattt gatgaggata      900

tggttataca agctcttcag aaaactaaca acagaagtat agaagcagca attgaattca      960

ttagtaaaat gagttaccaa gatcctcgac gagagcagat ggctgcagca gctgccagac     1020

ctattaatgc cagcatgaaa ccagggaatg tgcagcaatc agttaaccgc aaacagagct     1080

ggaaaggttc taaagaatcc ttagttcctc agaggcatgg cccgccacta ggagaaagtg     1140

tggcctatca ttctgagagt cccaactcac agacagatgt aggaagacct ttgtctggat     1200

ctggtatatc agcatttgtt caagctcacc ctagcaacgg acagagagtg aaccccccac     1260

caccacctca agtaaggagt gttactcctc caccacctcc aagaggccag actccccctc     1320

caagaggtac aactccacct cccccttcat gggaaccaaa ctctcaaaca aagcgctatt     1380

ctggaaacat ggaatacgta atctcccgaa tctctcctgt cccacctggg gcatggcaag     1440

agggctatcc tccaccacct ctcaacactt cccccatgaa tcctcctaat caaggacaga     1500

gaggcattag ttctgttcct gttggcagac aaccaatcat catgcagagt tctagcaaat     1560

ttaactttcc atcagggaga cctggaatgc agaatggtac tggacaaact gatttcatga     1620

tacaccaaaa tgttgtccct gctggcactg tgaatcggca gccaccacct ccatatcctc     1680

tgacagcagc taatggacaa agcccttctg ctttacaaac agggggatct gctgctcctt     1740

cgtcatatac aaatggaagt attcctcagt ctatgatggt gccaaacaga aatagtcata     1800

acatggaact atataacatt agtgtacctg gactgcaaac aaattggcct cagtcatctt     1860

ctgctccagc ccagtcatcc ccgagcagtg ggcatgaaat ccctacatgg caacctaaca     1920

taccagtgag gtcaaattct tttaataacc cattaggaaa tagagcaagt cactctgcta     1980

attctcagcc ttctgctaca acagtcactg caattacacc agctcctatt caacagcctg     2040

tgaaaagtat gcgtgtatta aaaccagagc tacagactgc tttagcacct acacaccctt     2100

cttggatacc acagccaatt caaactgttc aacccagtcc ttttcctgag ggaaccgctt     2160

caaatgtgac tgtgatgcca cctgttgctg aagctccaaa ctatcaagga ccaccaccac     2220

cctacccaaa acatctgctg caccaaaacc catctgttcc tccatacgag tcaatcagta     2280

agcctagcaa agaggatcag ccaagcttgc ccaaggaaga tgagagtgaa aagagttatg     2340

aaaatgttga tagtggggat aaagaaaaga aacagattac aacttcacct attactgtta     2400

ggaaaaacaa gaaagatgaa gagcgaaggg aatctcgtat tcaaagttat tctcctcaag     2460

catttaaatt ctttatggag caacatgtag aaaatgtact caaatctcat cagcagcgtc     2520

tacatcgtaa aaaacaatta gagaatgaaa tgatgcgggt tggattatct caagatgccc     2580

aggatcaaat gagaaagatg ctttgccaaa aagaatctaa ttacatccgt cttaaaaggg     2640

ctaaaatgga caagtctatg tttgtgaaga taaagacact aggaatagga gcatttggtg     2700

aagtctgtct agcaagaaaa gtagatacta aggctttgta tgcaacaaaa actcttcgaa     2760

agaaagatgt tcttcttcga aatcaagtcg ctcatgttaa ggctgagaga gatatcctgg     2820

ctgaagctga caatgaatgg gtagttcgtc tatattattc attccaagat aaggacaatt     2880

tatactttgt aatggactac attcctgggg gtgatatgat gagcctatta attagaatgg     2940

gcatctttcc agaaagtctg gcacgattct acatagcaga acttacctgt gcagttgaaa     3000

gtgttcataa aatgggtttt attcatagag atattaaacc tgataatatt ttgattgatc     3060

gtgatggtca tattaaattg actgactttg gcctctgcac tggcttcaga tggacacacg     3120

attctaagta ctatcagagt ggtgaccatc cacggcaaga tagcatggat ttcagtaatg     3180

aatgggggga tccctcaagc tgtcgatgtg gagacagact gaagccatta gagcggagag     3240

ctgcacgcca gcaccagcga tgtctagcac attctttggt tgggactccc aattatattg     3300

cacctgaagt gttgctacga acaggataca cacagttgtg tgattggtgg agtgttggtg     3360

ttattctttt tgaaatgttg gtgggacaac ctcctttctt ggcacaaaca ccattagaaa     3420

cacaaatgaa ggttatcaac tggcaaacat ctcttcacat tccaccacaa gctaaactca     3480

gtcctgaagc ttctgatctt attattaaac tttgccgagg acccgaagat cgcttaggca     3540

agaatggtgc tgatgaaata aaagctcatc cattttttaa aacaattgac ttctccagtg     3600

acctgagaca gcagtctgct tcatacattc ctaaaatcac acacccaaca gatacatcaa     3660

attttgatcc tgttgatcct gataaattat ggagtgatga taacgaggaa gaaaatgtaa     3720

atgacactct caatggatgg tataaaaatg gaaagcatcc tgaacatgca ttctatgaat     3780

ttaccttccg aaggtttttt gatgacaatg gctacccata taattatccg aagcctattg     3840

aatatgaata cattaattca caaggctcag agcagcagtc ggatgaagat gatcaaaaca     3900

caggctcaga gattaaaaat cgcgatctag tatatgttta acacactagt aaataaatgt     3960

aatgaggatt tgtaaaaggg cctgaaatgc gaggtgtttt gaggttctga gagtaaaatt     4020

atgcaaatat gacagagcta tatatgtgtg ctctgtgtac aatattttat tttcctaaat     4080

tatgggaaat ccttttaaaa tgttaattta ttccagccgt ttaaatcagt atttagaaaa     4140

aaattgttat aaggaaagta aattatgaac tgaatattat agtcagttct tggtacttaa     4200

agtacttaaa ataagtagtg ctttgtttaa aaggagaaac ctggtatcta tttgtatata     4260

tgctaaataa ttttaaaata caagagtttt tgaaattttt ttgaaagaca gttttagttt     4320

tatcttgctt taaccaaata tgaaacatac cccctatttt acagagctct tttttcccct     4380

cataaccttg tttttggtag aaaataagct agagaaatta agccatcgtg ttggtgagtg     4440

ttcctaggct aatgataatc tgtataattc acatcctgaa actaaggaat acagggttga     4500

aaaaatatta atatgtttgt cagaaggaaa aataatgcat ttatcttccc ccccaccccc     4560

cgccccatgg aatatttaat ctatttaatc ttcttgcatt tatttctcaa gaattactgg     4620

ctttaaaaga agccaaagca ctactagctt tttttccata ttggtatttt tgatgctgct     4680

tccaatttta aaagggaaca aagctgccat aaatcgaaat gttcaatact aaaagctaaa     4740

atatttctca ccatcctaag cagataatta ttttaatttt catatacttt tcctgtatag     4800

taactatttt gattatatca tcaatgttac ctgtttcctc tttcagaaca gtgctgcata     4860

tacagattgt tattggcaaa ggaaaatctg gctatctggc aatattttac ctaagcgcag     4920

attaattggt gaaaaaatta actcttaaga tggccattaa taattaggaa agtttacaga     4980

gtggtcttag tagaaaattc aagtcctcct aatttattta aggttcaata atgcgttcaa     5040

catgcctgtt atgtataacg cttaggttct aaggaagatt aaggtttcat accaaaatac     5100

atgtagctta tcttttagga aggggaaaaa ggctccattt tgaccatagt aaaatttgtg     5160

ttgtgtttta tttccttttc ttaagctcca ctgataaggg attgttttta tcaaaagtta     5220

ctatttgtag attggaggca taattttagt gattttcata cttttagctt tcttcgcata     5280

aaagctaatt gaaaccgtat atgtagtaaa attaaaggca gagctgttgc agttgaattg     5340

gagagttagg gcaaagaaca cttattagcc cacacttccc acctttctac aggtggtcct     5400

ttcagagctc agcctgaaaa cccactactg tgttatcgtg cgtcttttgg ggttagtggt     5460

tcttttgaga atctgaagga agctgtggac tcttcctaga aaaaaaaacc acacatacac     5520

atacaatgtt gcatgcagtt tcaagggatt ttggacatat tgaaacctat cacaggctgt     5580

aggttatgga cctctgtgcc atgagaaaat tgatacatta aactaagaac tttgttttta     5640

acttaccaat cactactcag cacatcttat ataagctgat aatttgtgat ggaaaaggtc     5700

tgtagcatgt gatataaggt gaccttatga atgcctctct tgctggtaca ttaagttgtt     5760

ttaatatatc atttggaggg gactgaaatg ttaggctcat tacaagcttg atacagaaat     5820

atttctgaag gatttctaat cagaattgta aaacaatgtg ctatcatgaa atcgcagtct     5880

tcacctcatg gttcatggaa catttggtta gtcccataaa atcctatgca aaacaaagta     5940

gttcaagaat ttttaggtgg gtagtcacat ttataaggta ttcctcttac tctttgggct     6000

ttttcagtct gatttattta aattttcatt tagttgtttt acttttggac taaggtgcaa     6060

tacagtagaa gataactttg ttacatttat gttgtaggaa aactaaggtg ctgtctcctc     6120

ccccttccct tcccacaaaa tctgtattcc ccctattgct gaaatgtaac agacactaca     6180

aattttgtat tctttttttg ttttttgttt tgagacaggg tctcactctg tcacccaggc     6240

tggagggcag tggcgcttca cagctcactg catcctcaac cttgggggct cacgcagtcc     6300

tcccgcctca gcctcccaag tagctgggca tgcgccacca agcccagcta atttttgtat     6360

ctttagtaga gatggggttt cgccatgttg cccaggttgg tgtggaattc ctgggctcca     6420

gttatatgcc cacctcagcc tcccaaagtg ctgggattac agacgtgacc caccgcgcct     6480

ggcgcaaata tgtattcttt taaaatttcc tctgatacta taagcttttt gcatttatct     6540

gaagcagtat acatgccttt ggtatcagca attttaacag tttggatata cttatcagct     6600

atcttattcc aaaactacat ctacttcttc cagtatagaa tctggtgctt cctgaccaaa     6660

aagatgagaa aaacaatgtt aaaaatatag atgctttcca ttgaaatgga gtgaaaacat     6720

tggttctata tgttttcttt taaaataatt ttcttattaa aaacttgctg tctttattat     6780

acttaccctt tttatgcata tcaatagtat ttataagatg tgttctataa ttatgtaatt     6840

gtagatactg ttatgcattg tccagtgaca tcataaggca ggccctactg ctgtatcttt     6900

tctaccttct tatttgtaat agaaactata gaatgtatga ctaaaaagtc actttgagat     6960

tgactttttt aaaaagttat taccttctgc tgttgcaaag tgcaaaactg tgagtggaat     7020

tgttttattc tgacttaatg tgttagaaat tagagaatac agtgggagga tttttagaca     7080

ttgctgctgc tgttacccaa ggtattttag ataaaaaatt tttaataaac atccctttgg     7140

tatttaaagt ggaacattta gcctgttcat tttaatctaa agcaaaaagt aatttgggtc     7200

aaaatattgg tatatttgta aagcgcctta atatatccct ttgtggaagg cactacacag     7260

tttactttta tattgtattg tgtatataag tattttgtat taaaattgaa tcagtggcaa     7320

cattaaagtt ttataaaatc atgctttgtt agaaaaagaa ttacagcttt gcaatataac     7380

taattgtttc gcataattct gaatgtaata gatatgaata atcagcctgt gtttttaatg     7440

aacttatttg tattttccca atcattttct ctagtgtaat gtttgctggg ataataaaaa     7500

aaattcaaat ctttcaaaaa aaaaaaaaaa aaa                                  7533


<210>  2
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Arg Ser Glu Lys Pro Glu Gly Tyr Arg Gln Met Arg Pro Lys 
1               5                   10                  15      


Thr Phe Pro Ala Ser Asn Tyr Thr Val Ser Ser Arg Gln Met Leu Gln 
            20                  25                  30          


Glu Ile Arg Glu Ser Leu Arg Asn Leu Ser Lys Pro Ser Asp Ala Ala 
        35                  40                  45              


Lys Ala Glu His Asn Met Ser Lys Met Ser Thr Glu Asp Pro Arg Gln 
    50                  55                  60                  


Val Arg Asn Pro Pro Lys Phe Gly Thr His His Lys Ala Leu Gln Glu 
65                  70                  75                  80  


Ile Arg Asn Ser Leu Leu Pro Phe Ala Asn Glu Thr Asn Ser Ser Arg 
                85                  90                  95      


Ser Thr Ser Glu Val Asn Pro Gln Met Leu Gln Asp Leu Gln Ala Ala 
            100                 105                 110         


Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn 
        115                 120                 125             


Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met Ser Tyr Gln 
    130                 135                 140                 


Asp Pro Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn 
145                 150                 155                 160 


Ala Ser Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys Gln 
                165                 170                 175     


Ser Trp Lys Gly Ser Lys Glu Ser Leu Val Pro Gln Arg His Gly Pro 
            180                 185                 190         


Pro Leu Gly Glu Ser Val Ala Tyr His Ser Glu Ser Pro Asn Ser Gln 
        195                 200                 205             


Thr Asp Val Gly Arg Pro Leu Ser Gly Ser Gly Ile Ser Ala Phe Val 
    210                 215                 220                 


Gln Ala His Pro Ser Asn Gly Gln Arg Val Asn Pro Pro Pro Pro Pro 
225                 230                 235                 240 


Gln Val Arg Ser Val Thr Pro Pro Pro Pro Pro Arg Gly Gln Thr Pro 
                245                 250                 255     


Pro Pro Arg Gly Thr Thr Pro Pro Pro Pro Ser Trp Glu Pro Asn Ser 
            260                 265                 270         


Gln Thr Lys Arg Tyr Ser Gly Asn Met Glu Tyr Val Ile Ser Arg Ile 
        275                 280                 285             


Ser Pro Val Pro Pro Gly Ala Trp Gln Glu Gly Tyr Pro Pro Pro Pro 
    290                 295                 300                 


Leu Asn Thr Ser Pro Met Asn Pro Pro Asn Gln Gly Gln Arg Gly Ile 
305                 310                 315                 320 


Ser Ser Val Pro Val Gly Arg Gln Pro Ile Ile Met Gln Ser Ser Ser 
                325                 330                 335     


Lys Phe Asn Phe Pro Ser Gly Arg Pro Gly Met Gln Asn Gly Thr Gly 
            340                 345                 350         


Gln Thr Asp Phe Met Ile His Gln Asn Val Val Pro Ala Gly Thr Val 
        355                 360                 365             


Asn Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln 
    370                 375                 380                 


Ser Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr 
385                 390                 395                 400 


Thr Asn Gly Ser Ile Pro Gln Ser Met Met Val Pro Asn Arg Asn Ser 
                405                 410                 415     


His Asn Met Glu Leu Tyr Asn Ile Ser Val Pro Gly Leu Gln Thr Asn 
            420                 425                 430         


Trp Pro Gln Ser Ser Ser Ala Pro Ala Gln Ser Ser Pro Ser Ser Gly 
        435                 440                 445             


His Glu Ile Pro Thr Trp Gln Pro Asn Ile Pro Val Arg Ser Asn Ser 
    450                 455                 460                 


Phe Asn Asn Pro Leu Gly Asn Arg Ala Ser His Ser Ala Asn Ser Gln 
465                 470                 475                 480 


Pro Ser Ala Thr Thr Val Thr Ala Ile Thr Pro Ala Pro Ile Gln Gln 
                485                 490                 495     


Pro Val Lys Ser Met Arg Val Leu Lys Pro Glu Leu Gln Thr Ala Leu 
            500                 505                 510         


Ala Pro Thr His Pro Ser Trp Ile Pro Gln Pro Ile Gln Thr Val Gln 
        515                 520                 525             


Pro Ser Pro Phe Pro Glu Gly Thr Ala Ser Asn Val Thr Val Met Pro 
    530                 535                 540                 


Pro Val Ala Glu Ala Pro Asn Tyr Gln Gly Pro Pro Pro Pro Tyr Pro 
545                 550                 555                 560 


Lys His Leu Leu His Gln Asn Pro Ser Val Pro Pro Tyr Glu Ser Ile 
                565                 570                 575     


Ser Lys Pro Ser Lys Glu Asp Gln Pro Ser Leu Pro Lys Glu Asp Glu 
            580                 585                 590         


Ser Glu Lys Ser Tyr Glu Asn Val Asp Ser Gly Asp Lys Glu Lys Lys 
        595                 600                 605             


Gln Ile Thr Thr Ser Pro Ile Thr Val Arg Lys Asn Lys Lys Asp Glu 
    610                 615                 620                 


Glu Arg Arg Glu Ser Arg Ile Gln Ser Tyr Ser Pro Gln Ala Phe Lys 
625                 630                 635                 640 


Phe Phe Met Glu Gln His Val Glu Asn Val Leu Lys Ser His Gln Gln 
                645                 650                 655     


Arg Leu His Arg Lys Lys Gln Leu Glu Asn Glu Met Met Arg Val Gly 
            660                 665                 670         


Leu Ser Gln Asp Ala Gln Asp Gln Met Arg Lys Met Leu Cys Gln Lys 
        675                 680                 685             


Glu Ser Asn Tyr Ile Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met 
    690                 695                 700                 


Phe Val Lys Ile Lys Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys 
705                 710                 715                 720 


Leu Ala Arg Lys Val Asp Thr Lys Ala Leu Tyr Ala Thr Lys Thr Leu 
                725                 730                 735     


Arg Lys Lys Asp Val Leu Leu Arg Asn Gln Val Ala His Val Lys Ala 
            740                 745                 750         


Glu Arg Asp Ile Leu Ala Glu Ala Asp Asn Glu Trp Val Val Arg Leu 
        755                 760                 765             


Tyr Tyr Ser Phe Gln Asp Lys Asp Asn Leu Tyr Phe Val Met Asp Tyr 
    770                 775                 780                 


Ile Pro Gly Gly Asp Met Met Ser Leu Leu Ile Arg Met Gly Ile Phe 
785                 790                 795                 800 


Pro Glu Ser Leu Ala Arg Phe Tyr Ile Ala Glu Leu Thr Cys Ala Val 
                805                 810                 815     


Glu Ser Val His Lys Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp 
            820                 825                 830         


Asn Ile Leu Ile Asp Arg Asp Gly His Ile Lys Leu Thr Asp Phe Gly 
        835                 840                 845             


Leu Cys Thr Gly Phe Arg Trp Thr His Asp Ser Lys Tyr Tyr Gln Ser 
    850                 855                 860                 


Gly Asp His Pro Arg Gln Asp Ser Met Asp Phe Ser Asn Glu Trp Gly 
865                 870                 875                 880 


Asp Pro Ser Ser Cys Arg Cys Gly Asp Arg Leu Lys Pro Leu Glu Arg 
                885                 890                 895     


Arg Ala Ala Arg Gln His Gln Arg Cys Leu Ala His Ser Leu Val Gly 
            900                 905                 910         


Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Leu Arg Thr Gly Tyr Thr 
        915                 920                 925             


Gln Leu Cys Asp Trp Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu 
    930                 935                 940                 


Val Gly Gln Pro Pro Phe Leu Ala Gln Thr Pro Leu Glu Thr Gln Met 
945                 950                 955                 960 


Lys Val Ile Asn Trp Gln Thr Ser Leu His Ile Pro Pro Gln Ala Lys 
                965                 970                 975     


Leu Ser Pro Glu Ala Ser Asp Leu Ile Ile Lys Leu Cys Arg Gly Pro 
            980                 985                 990         


Glu Asp Arg Leu Gly Lys Asn Gly  Ala Asp Glu Ile Lys  Ala His Pro 
        995                 1000                 1005             


Phe Phe  Lys Thr Ile Asp Phe  Ser Ser Asp Leu Arg  Gln Gln Ser 
    1010                 1015                 1020             


Ala Ser  Tyr Ile Pro Lys Ile  Thr His Pro Thr Asp  Thr Ser Asn 
    1025                 1030                 1035             


Phe Asp  Pro Val Asp Pro Asp  Lys Leu Trp Ser Asp  Asp Asn Glu 
    1040                 1045                 1050             


Glu Glu  Asn Val Asn Asp Thr  Leu Asn Gly Trp Tyr  Lys Asn Gly 
    1055                 1060                 1065             


Lys His  Pro Glu His Ala Phe  Tyr Glu Phe Thr Phe  Arg Arg Phe 
    1070                 1075                 1080             


Phe Asp  Asp Asn Gly Tyr Pro  Tyr Asn Tyr Pro Lys  Pro Ile Glu 
    1085                 1090                 1095             


Tyr Glu  Tyr Ile Asn Ser Gln  Gly Ser Glu Gln Gln  Ser Asp Glu 
    1100                 1105                 1110             


Asp Asp  Gln Asn Thr Gly Ser  Glu Ile Lys Asn Arg  Asp Leu Val 
    1115                 1120                 1125             


Tyr Val  
    1130 


<210>  3
<211>  5558
<212>  DNA
<213>  Homo sapiens

<400>  3
gcccgtggaa tgccaacaat gtagcgaatg tcccacttgg gtctgcgctt tggaaccgcg       60

gcgtgagcgc cccgggaaga tggagcagtc gccgtccacg ccaccgccgc cgcccggggc      120

tcccccgtcc ctgcggggcc agcagcagct ccagccacca gtgcccggtc tcccggcgcg      180

agaggcccgg gagccgccgg ccaggacgcc cccgagggtg tagaccgcgc ccctggagag      240

agtgataatc ttcaaaatga agactttgga aaattttagg ttctctatag gaactacaaa      300

aatggaagga aagaacattt tcaaaaggaa attattttga aagtatgttt acaacaaact      360

gatactattg acagtttttt tttttaaata ataaaacact ttaagaagat tgtatttatg      420

gtaaaaggaa actggactaa caatgaggcc aaagactttt cctgccacga cttattctgg      480

aaatagccgg cagcgactgc aagagattcg tgaggggtta aaacagccat ccaagtcttc      540

ggttcagggg ctacccgcag gaccaaacag tgacacttcc ctggatgcca aagtcctggg      600

gagcaaagat gccaccaggc agcagcagca gatgagagcc accccaaagt tcggacctta      660

tcagaaagcc ttgagggaaa tcagatattc cttgttgcct tttgctaatg aatcgggcac      720

ctctgcagct gcagaagtga accggcaaat gctgcaggaa ctggtgaacg caggatgcga      780

ccaggagatg gctggccgag ctctcaagca gactggcagc aggagcatcg aggccgccct      840

ggagtacatc agcaagatgg gctacctgga cccgaggaat gagcagattg tgcgggtcat      900

taagcagacc tccccaggaa aggggctcat gccaacccca gtgacgcgga ggcccagctt      960

cgaaggaacc ggcgattcgt ttgcgtccta ccaccagctg agcggtaccc cctacgaggg     1020

cccaagcttc ggcgctgacg gccccacggc gctggaggag atgccgcggc cgtacgtgga     1080

ctaccttttc cccggagtcg gcccccacgg gcccggccac cagcaccagc acccacccaa     1140

gggctacggt gccagcgtag aggcagcagg ggcacacttc ccgctgcagg gcgcgcacta     1200

cgggcggccg cacctgctgg tgcctgggga acccctgggc tacggagtgc agcgcagccc     1260

ctccttccag agcaagacgc cgccggagac cgggggttac gccagcctgc ccacgaaggg     1320

ccagggagga ccgccaggcg ccggcctcgc tttcccaccc cctgccgccg ggctctacgt     1380

gccgcaccca caccacaagc aggccggtcc cgcggcccac cagctgcatg tgctgggctc     1440

ccgcagccag gtgttcgcca gcgacagccc cccgcagagc ctgctcactc cctcgcggaa     1500

cagcctcaac gtggacctgt atgaattggg cagcacctcc gtccagcagt ggccggctgc     1560

caccctggcc cgccgggact ccctgcagaa gccgggcctg gaggcgccgc cgcgcgcgca     1620

cgtggccttc cggcctgact gcccagtgcc cagcaggacc aactccttca acagccacca     1680

gccgcggccc ggtccgcctg gcaaggccga gccctccctg cccgccccca acaccgtgac     1740

ggctgtcacg gccgcgcaca tcttgcaccc ggtgaagagc gtgcgtgtgc tgaggccgga     1800

gccgcagacg gctgtggggc cctcgcaccc cgcctgggtg cccgcgcctg ccccggcccc     1860

cgcccccgcc cccgccccgg ctgcggaggg cttggacgcc aaggaggagc atgccctggc     1920

gctgggcggc gcaggcgcct tcccgctgga cgtggagtac ggaggcccag accggaggtg     1980

cccgcctccg ccctacccga agcacctgct gctgcgcagc aagtcggagc agtacgacct     2040

ggacagcctg tgcgcaggca tggagcagag cctccgtgcg ggccccaacg agcccgaggg     2100

cggcgacaag agccgcaaaa gcgccaaggg ggacaaaggc ggaaaggata aaaagcagat     2160

tcagacctct cccgttcccg tccgcaaaaa cagcagagac gaagagaaga gagagtcacg     2220

catcaagagc tactcgccat acgcctttaa gttcttcatg gagcagcacg tggagaatgt     2280

catcaaaacc taccagcaga aggttaaccg gaggctgcag ctggagcaag aaatggccaa     2340

agctggactc tgtgaagctg agcaggagca gatgcggaag atcctctacc agaaagagtc     2400

taattacaac aggttaaaga gggccaagat ggacaagtct atgtttgtca agatcaaaac     2460

cctggggatc ggtgcctttg gagaagtgtg ccttgcttgt aaggtggaca ctcacgccct     2520

gtacgccatg aagaccctaa ggaaaaagga tgtcctgaac cggaatcagg tggcccacgt     2580

caaggccgag agggacatcc tggccgaggc agacaatgag tgggtggtca aactctacta     2640

ctccttccaa gacaaagaca gcctgtactt tgtgatggac tacatccctg gtggggacat     2700

gatgagcctg ctgatccgga tggaggtctt ccctgagcac ctggcccggt tctacatcgc     2760

agagctgact ttggccattg agagtgtcca caagatgggc ttcatccacc gagacatcaa     2820

gcctgataac attttgatag atctggatgg tcacattaaa ctcacagatt tcggcctctg     2880

cactgggttc aggtggactc acaattccaa atattaccag aaagggagcc atgtcagaca     2940

ggacagcatg gagcccagcg acctctggga tgatgtgtct aactgtcggt gtggggacag     3000

gctgaagacc ctagagcaga gggcgcggaa gcagcaccag aggtgcctgg cacattcact     3060

ggtggggact ccaaactaca tcgcacccga ggtgctcctc cgcaaagggt acactcaact     3120

ctgtgactgg tggagtgttg gagtgattct cttcgagatg ctggtggggc agccgccctt     3180

tttggcacct actcccacag aaacccagct gaaggtgatc aactgggaga acacgctcca     3240

cattccagcc caggtgaagc tgagccctga ggccagggac ctcatcacca agctgtgctg     3300

ctccgcagac caccgcctgg ggcggaatgg ggccgatgac ctgaaggccc accccttctt     3360

cagcgccatt gacttctcca gtgacatccg gaagcagcca gccccctacg ttcccaccat     3420

cagccacccc atggacacct cgaatttcga ccccgtagat gaagaaagcc cttggaacga     3480

tgccagcgaa ggtagcacca aggcctggga cacactcacc tcgcccaata acaagcatcc     3540

tgagcacgca ttttacgaat tcaccttccg aaggttcttt gatgacaatg gctacccctt     3600

tcgatgccca aagccttcag gagcagaagc ttcacaggct gagagctcag atttagaaag     3660

ctctgatctg gtggatcaga ctgaaggctg ccagcctgtg tacgtgtaga tgggggccag     3720

gcacccccac cactcgctgc ctcccaggtc agggtcccgg agccggtgcc ctcacaggcc     3780

aatagggaag ccgagggctg ttttgtttta aattagtccg tcgattactt cacttgaaat     3840

tctgctcttc accaagaaaa cccaaacagg acacttttga aaacaggact cagcatcgct     3900

ttcaataggc ttttcaggac cttcactgca ttaaaacaat atttttgaaa atttagtaca     3960

gtttagaaag agcacttatt ttgtttatat ccattttttc ttactaaatt atagggatta     4020

actttgacaa atcatgctgc tgttattttc tacatttgta ttttatccat agcacttatt     4080

cacatttagg aaaagacata aaaactgaag aacattgatg agaaatctct gtgcaataat     4140

gtaaaaaaaa aaaaagataa cactctgctc aatgtcacgg agaccatttt atccacacaa     4200

tggtttttgt tttttatttt ttcccatgtt tcaaaattgt gatataatga tataatgtta     4260

aaagctgctt tttttggctt tttgcatatc tagtataata ggaagtgtga gcaaggtgat     4320

gatgtggctg tgatttccga cgtctggtgt gtggagagta ctgcatgagc agagttcttc     4380

tattataaaa ttaccatatc ttgccattca cagcaggtcc tgtgaatacg tttttactga     4440

gtgtctttaa atgaggtgtt ctagacagtg tgctgataat gtattgtgcg ggtgacctct     4500

tcgctatgat tgtatctctt actgttttgt taaagaaatg cagatgtgta actgagaagt     4560

gatttgtgtg tgtgtcttgg ttgtgattgg attctttggg gggggggaac tgaaacattt     4620

gtcatatact gaacttatat acatcaaaag ggattaatac agcgatgcca aaaagtttaa     4680

tcacggacac atgtccgttt ctgtagtccg tatgctcttt cattcttggt agagctggta     4740

tgtggaatgc catacctctg accctactac ttaccttttt actgacagac tgcccacact     4800

gaaagcttca gtgaatgttc ttagtcctgt tttcttctgt tactgtcagg aaactgagtg     4860

atctaatggt tctctcactt tttttttgtt cttttagtgt actttgaagt atcaaatctt     4920

aacttggttt aaacaataca tattcctaac ctttgtaaaa aagcaaagat tcttcaaaat     4980

gacattgaaa taaaaagtaa gccatacgta ttttcttaga agtatagatg tatgtgcgtg     5040

tatacacaca cacacacaca cacagagata aacacaatat tccttatttc aaattagtat     5100

gattcctatt taaagtgatt tatatttgag taaaaagttc aattcttttt tgctttttaa     5160

aaaatctgat gcttcataat tttcattata ttattccaca tatttttcct tgaagttctt     5220

agcataatgt atccattact tagtatatat ctaggcaaca acacttagaa gtttatcagt     5280

gtttaaacta aaaaaataaa gattcctgtg tactggttta catttgtgtg agtggcatac     5340

tcaagtctgc tgtgcctgtc gtcgtgactg tcagtattct cgctatttta tagtcgtgcc     5400

atgttgttac tcacagcgct ctgacatact ttcatgtggt aggttctttc tcaggaactc     5460

agtttaacta ttatttattg atatatcatt acctttgaaa agcttctact ggcacaattt     5520

attattaaaa ttttgaatcc aaaaaaaaaa aaaaaaaa                             5558


<210>  4
<211>  1088
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Pro Lys Thr Phe Pro Ala Thr Thr Tyr Ser Gly Asn Ser Arg 
1               5                   10                  15      


Gln Arg Leu Gln Glu Ile Arg Glu Gly Leu Lys Gln Pro Ser Lys Ser 
            20                  25                  30          


Ser Val Gln Gly Leu Pro Ala Gly Pro Asn Ser Asp Thr Ser Leu Asp 
        35                  40                  45              


Ala Lys Val Leu Gly Ser Lys Asp Ala Thr Arg Gln Gln Gln Gln Met 
    50                  55                  60                  


Arg Ala Thr Pro Lys Phe Gly Pro Tyr Gln Lys Ala Leu Arg Glu Ile 
65                  70                  75                  80  


Arg Tyr Ser Leu Leu Pro Phe Ala Asn Glu Ser Gly Thr Ser Ala Ala 
                85                  90                  95      


Ala Glu Val Asn Arg Gln Met Leu Gln Glu Leu Val Asn Ala Gly Cys 
            100                 105                 110         


Asp Gln Glu Met Ala Gly Arg Ala Leu Lys Gln Thr Gly Ser Arg Ser 
        115                 120                 125             


Ile Glu Ala Ala Leu Glu Tyr Ile Ser Lys Met Gly Tyr Leu Asp Pro 
    130                 135                 140                 


Arg Asn Glu Gln Ile Val Arg Val Ile Lys Gln Thr Ser Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Met Pro Thr Pro Val Thr Arg Arg Pro Ser Phe Glu Gly Thr 
                165                 170                 175     


Gly Asp Ser Phe Ala Ser Tyr His Gln Leu Ser Gly Thr Pro Tyr Glu 
            180                 185                 190         


Gly Pro Ser Phe Gly Ala Asp Gly Pro Thr Ala Leu Glu Glu Met Pro 
        195                 200                 205             


Arg Pro Tyr Val Asp Tyr Leu Phe Pro Gly Val Gly Pro His Gly Pro 
    210                 215                 220                 


Gly His Gln His Gln His Pro Pro Lys Gly Tyr Gly Ala Ser Val Glu 
225                 230                 235                 240 


Ala Ala Gly Ala His Phe Pro Leu Gln Gly Ala His Tyr Gly Arg Pro 
                245                 250                 255     


His Leu Leu Val Pro Gly Glu Pro Leu Gly Tyr Gly Val Gln Arg Ser 
            260                 265                 270         


Pro Ser Phe Gln Ser Lys Thr Pro Pro Glu Thr Gly Gly Tyr Ala Ser 
        275                 280                 285             


Leu Pro Thr Lys Gly Gln Gly Gly Pro Pro Gly Ala Gly Leu Ala Phe 
    290                 295                 300                 


Pro Pro Pro Ala Ala Gly Leu Tyr Val Pro His Pro His His Lys Gln 
305                 310                 315                 320 


Ala Gly Pro Ala Ala His Gln Leu His Val Leu Gly Ser Arg Ser Gln 
                325                 330                 335     


Val Phe Ala Ser Asp Ser Pro Pro Gln Ser Leu Leu Thr Pro Ser Arg 
            340                 345                 350         


Asn Ser Leu Asn Val Asp Leu Tyr Glu Leu Gly Ser Thr Ser Val Gln 
        355                 360                 365             


Gln Trp Pro Ala Ala Thr Leu Ala Arg Arg Asp Ser Leu Gln Lys Pro 
    370                 375                 380                 


Gly Leu Glu Ala Pro Pro Arg Ala His Val Ala Phe Arg Pro Asp Cys 
385                 390                 395                 400 


Pro Val Pro Ser Arg Thr Asn Ser Phe Asn Ser His Gln Pro Arg Pro 
                405                 410                 415     


Gly Pro Pro Gly Lys Ala Glu Pro Ser Leu Pro Ala Pro Asn Thr Val 
            420                 425                 430         


Thr Ala Val Thr Ala Ala His Ile Leu His Pro Val Lys Ser Val Arg 
        435                 440                 445             


Val Leu Arg Pro Glu Pro Gln Thr Ala Val Gly Pro Ser His Pro Ala 
    450                 455                 460                 


Trp Val Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
465                 470                 475                 480 


Ala Glu Gly Leu Asp Ala Lys Glu Glu His Ala Leu Ala Leu Gly Gly 
                485                 490                 495     


Ala Gly Ala Phe Pro Leu Asp Val Glu Tyr Gly Gly Pro Asp Arg Arg 
            500                 505                 510         


Cys Pro Pro Pro Pro Tyr Pro Lys His Leu Leu Leu Arg Ser Lys Ser 
        515                 520                 525             


Glu Gln Tyr Asp Leu Asp Ser Leu Cys Ala Gly Met Glu Gln Ser Leu 
    530                 535                 540                 


Arg Ala Gly Pro Asn Glu Pro Glu Gly Gly Asp Lys Ser Arg Lys Ser 
545                 550                 555                 560 


Ala Lys Gly Asp Lys Gly Gly Lys Asp Lys Lys Gln Ile Gln Thr Ser 
                565                 570                 575     


Pro Val Pro Val Arg Lys Asn Ser Arg Asp Glu Glu Lys Arg Glu Ser 
            580                 585                 590         


Arg Ile Lys Ser Tyr Ser Pro Tyr Ala Phe Lys Phe Phe Met Glu Gln 
        595                 600                 605             


His Val Glu Asn Val Ile Lys Thr Tyr Gln Gln Lys Val Asn Arg Arg 
    610                 615                 620                 


Leu Gln Leu Glu Gln Glu Met Ala Lys Ala Gly Leu Cys Glu Ala Glu 
625                 630                 635                 640 


Gln Glu Gln Met Arg Lys Ile Leu Tyr Gln Lys Glu Ser Asn Tyr Asn 
                645                 650                 655     


Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met Phe Val Lys Ile Lys 
            660                 665                 670         


Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys Leu Ala Cys Lys Val 
        675                 680                 685             


Asp Thr His Ala Leu Tyr Ala Met Lys Thr Leu Arg Lys Lys Asp Val 
    690                 695                 700                 


Leu Asn Arg Asn Gln Val Ala His Val Lys Ala Glu Arg Asp Ile Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Asn Glu Trp Val Val Lys Leu Tyr Tyr Ser Phe Gln 
                725                 730                 735     


Asp Lys Asp Ser Leu Tyr Phe Val Met Asp Tyr Ile Pro Gly Gly Asp 
            740                 745                 750         


Met Met Ser Leu Leu Ile Arg Met Glu Val Phe Pro Glu His Leu Ala 
        755                 760                 765             


Arg Phe Tyr Ile Ala Glu Leu Thr Leu Ala Ile Glu Ser Val His Lys 
    770                 775                 780                 


Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp Asn Ile Leu Ile Asp 
785                 790                 795                 800 


Leu Asp Gly His Ile Lys Leu Thr Asp Phe Gly Leu Cys Thr Gly Phe 
                805                 810                 815     


Arg Trp Thr His Asn Ser Lys Tyr Tyr Gln Lys Gly Ser His Val Arg 
            820                 825                 830         


Gln Asp Ser Met Glu Pro Ser Asp Leu Trp Asp Asp Val Ser Asn Cys 
        835                 840                 845             


Arg Cys Gly Asp Arg Leu Lys Thr Leu Glu Gln Arg Ala Arg Lys Gln 
    850                 855                 860                 


His Gln Arg Cys Leu Ala His Ser Leu Val Gly Thr Pro Asn Tyr Ile 
865                 870                 875                 880 


Ala Pro Glu Val Leu Leu Arg Lys Gly Tyr Thr Gln Leu Cys Asp Trp 
                885                 890                 895     


Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu Val Gly Gln Pro Pro 
            900                 905                 910         


Phe Leu Ala Pro Thr Pro Thr Glu Thr Gln Leu Lys Val Ile Asn Trp 
        915                 920                 925             


Glu Asn Thr Leu His Ile Pro Ala Gln Val Lys Leu Ser Pro Glu Ala 
    930                 935                 940                 


Arg Asp Leu Ile Thr Lys Leu Cys Cys Ser Ala Asp His Arg Leu Gly 
945                 950                 955                 960 


Arg Asn Gly Ala Asp Asp Leu Lys Ala His Pro Phe Phe Ser Ala Ile 
                965                 970                 975     


Asp Phe Ser Ser Asp Ile Arg Lys Gln Pro Ala Pro Tyr Val Pro Thr 
            980                 985                 990         


Ile Ser His Pro Met Asp Thr Ser  Asn Phe Asp Pro Val  Asp Glu Glu 
        995                 1000                 1005             


Ser Pro  Trp Asn Asp Ala Ser  Glu Gly Ser Thr Lys  Ala Trp Asp 
    1010                 1015                 1020             


Thr Leu  Thr Ser Pro Asn Asn  Lys His Pro Glu His  Ala Phe Tyr 
    1025                 1030                 1035             


Glu Phe  Thr Phe Arg Arg Phe  Phe Asp Asp Asn Gly  Tyr Pro Phe 
    1040                 1045                 1050             


Arg Cys  Pro Lys Pro Ser Gly  Ala Glu Ala Ser Gln  Ala Glu Ser 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ser Asp  Leu Val Asp Gln Thr  Glu Gly Cys 
    1070                 1075                 1080             


Gln Pro  Val Tyr Val 
    1085             


<210>  5
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  5
gggctaaagg gctcagagtg caggccgtgg ggcgcgaggg tcccgggcct gagccccgcg       60

ccatggccgg ggccatcgct tcccgcatga gcttcagctc tctcaagagg aagcaaccca      120

agacgttcac cgtgaggatc gtcaccatgg acgccgagat ggagttcaat tgcgagatga      180

agtggaaagg gaaggacctc tttgatttgg tgtgccggac tctggggctc cgagaaacct      240

ggttctttgg actgcagtac acaatcaagg acacagtggc ctggctcaaa atggacaaga      300

aggtactgga tcatgatgtt tcaaaggaag aaccagtcac ctttcacttc ttggccaaat      360

tttatcctga gaatgctgaa gaggagctgg ttcaggagat cacacaacat ttattcttct      420

tacaggtaaa gaagcagatt ttagatgaaa agatctactg ccctcctgag gcttctgtgc      480

tcctggcttc ttacgccgtc caggccaagt atggtgacta cgaccccagt gttcacaagc      540

ggggattttt ggcccaagag gaattgcttc caaaaagggt aataaatctg tatcagatga      600

ctccggaaat gtgggaggag agaattactg cttggtacgc agagcaccga ggccgagcca      660

gggatgaagc tgaaatggaa tatctgaaga tagctcagga cctggagatg tacggtgtga      720

actactttgc aatccggaat aaaaagggca cagagctgct gcttggagtg gatgccctgg      780

ggcttcacat ttatgaccct gagaacagac tgacccccaa gatctccttc ccgtggaatg      840

aaatccgaaa catctcgtac agtgacaagg agtttactat taaaccactg gataagaaaa      900

ttgatgtctt caagtttaac tcctcaaagc ttcgtgttaa taagctgatt ctccagctat      960

gtatcgggaa ccatgatcta tttatgagga gaaggaaagc cgattctttg gaagttcagc     1020

agatgaaagc ccaggccagg gaggagaagg ctagaaagca gatggagcgg cagcgcctcg     1080

ctcgagagaa gcagatgagg gaggaggctg aacgcacgag ggatgagttg gagaggaggc     1140

tgctgcagat gaaagaagaa gcaacaatgg ccaacgaagc actgatgcgg tctgaggaga     1200

cagctgacct gttggctgaa aaggcccaga tcaccgagga ggaggcaaaa cttctggccc     1260

agaaggccgc agaggctgag caggaaatgc agcgcatcaa ggccacagcg attcgcacgg     1320

aggaggagaa gcgcctgatg gagcagaagg tgctggaagc cgaggtgctg gcactgaaga     1380

tggctgagga gtcagagagg agggccaaag aggcagatca gctgaagcag gacctgcagg     1440

aagcacgcga ggcggagcga agagccaagc agaagctcct ggagattgcc accaagccca     1500

cgtacccgcc catgaaccca attccagcac cgttgcctcc tgacatacca agcttcaacc     1560

tcattggtga cagcctgtct ttcgacttca aagatactga catgaagcgg ctttccatgg     1620

agatagagaa agaaaaagtg gaatacatgg aaaagagcaa gcatctgcag gagcagctca     1680

atgaactcaa gacagaaatc gaggccttga aactgaaaga gagggagaca gctctggata     1740

ttctgcacaa tgagaactcc gacaggggtg gcagcagcaa gcacaatacc attaaaaagc     1800

tcaccttgca gagcgccaag tcccgagtgg ccttctttga agagctctag caggtgaccc     1860

agccacccca ggacctgcca cttctcctgc tac                                  1893


<210>  6
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 
1               5                   10                  15      


Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 
            20                  25                  30          


Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 
        35                  40                  45              


Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 
    50                  55                  60                  


Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 
65                  70                  75                  80  


Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 
                85                  90                  95      


Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 
            100                 105                 110         


Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 
        115                 120                 125             


Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 
145                 150                 155                 160 


Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 
                165                 170                 175     


Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 
            180                 185                 190         


Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 
        195                 200                 205             


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 
    210                 215                 220                 


Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 
225                 230                 235                 240 


Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 
                245                 250                 255     


Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 
            260                 265                 270         


Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 
        275                 280                 285             


Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 
    290                 295                 300                 


Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 
305                 310                 315                 320 


Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 
                325                 330                 335     


Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 
            340                 345                 350         


Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 
        355                 360                 365             


Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 
    370                 375                 380                 


Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 
385                 390                 395                 400 


Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 
                405                 410                 415     


Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 
            420                 425                 430         


Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 
        435                 440                 445             


Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 
    450                 455                 460                 


Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 
465                 470                 475                 480 


Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 
                485                 490                 495     


Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 
            500                 505                 510         


Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 
        515                 520                 525             


Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 
    530                 535                 540                 


Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 
545                 550                 555                 560 


Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 
                565                 570                 575     


Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe 
            580                 585                 590         


Glu Glu Leu 
        595 


<210>  7
<211>  5396
<212>  DNA
<213>  Homo sapiens

<400>  7
gccgccgcca gggaaaagaa agggaggaag gaaggaacaa gaaaaggaaa taaagagaaa       60

ggggaggcgg ggaaaggcaa cgagctgtcc ggcctccgtc aagggagttg gagggaaaaa      120

gttctcaggc gccgcaggtc cgagtgcctc gcagcccctc ccgaggcgca gccgccagac      180

cagtggagcc ggggcgcagg gcgggggcgg aggcgccggg gcgggggatg cggggccgcg      240

gcgcagcccc ccggccctga gagcgaggac agcgccgccc ggcccgcagc cgtcgccgct      300

tctccacctc ggcccgtgga gccggggcgt ccgggcgtag ccctcgctcg cctgggtcag      360

ggggtgcgcg tcgggggagg cagaagccat ggatcccggg cagcagccgc cgcctcaacc      420

ggccccccag ggccaagggc agccgccttc gcagcccccg caggggcagg gcccgccgtc      480

cggacccggg caaccggcac ccgcggcgac ccaggcggcg ccgcaggcac cccccgccgg      540

gcatcagatc gtgcacgtcc gcggggactc ggagaccgac ctggaggcgc tcttcaacgc      600

cgtcatgaac cccaagacgg ccaacgtgcc ccagaccgtg cccatgaggc tccggaagct      660

gcccgactcc ttcttcaagc cgccggagcc caaatcccac tcccgacagg ccagtactga      720

tgcaggcact gcaggagccc tgactccaca gcatgttcga gctcattcct ctccagcttc      780

tctgcagttg ggagctgttt ctcctgggac actgaccccc actggagtag tctctggccc      840

agcagctaca cccacagctc agcatcttcg acagtcttct tttgagatac ctgatgatgt      900

acctctgcca gcaggttggg agatggcaaa gacatcttct ggtcagagat acttcttaaa      960

tcacatcgat cagacaacaa catggcagga ccccaggaag gccatgctgt cccagatgaa     1020

cgtcacagcc cccaccagtc caccagtgca gcagaatatg atgaactcgg cttcaggtcc     1080

tcttcctgat ggatgggaac aagccatgac tcaggatgga gaaatttact atataaacca     1140

taagaacaag accacctctt ggctagaccc aaggcttgac cctcgttttg ccatgaacca     1200

gagaatcagt cagagtgctc cagtgaaaca gccaccaccc ctggctcccc agagcccaca     1260

gggaggcgtc atgggtggca gcaactccaa ccagcagcaa cagatgcgac tgcagcaact     1320

gcagatggag aaggagaggc tgcggctgaa acagcaagaa ctgcttcggc aggcaatgcg     1380

gaatatcaat cccagcacag caaattctcc aaaatgtcag gagttagccc tgcgtagcca     1440

gttaccaaca ctggagcagg atggtgggac tcaaaatcca gtgtcttctc ccgggatgtc     1500

tcaggaattg agaacaatga cgaccaatag ctcagatcct ttccttaaca gtggcaccta     1560

tcactctcga gatgagagta cagacagtgg actaagcatg agcagctaca gtgtccctcg     1620

aaccccagat gacttcctga acagtgtgga tgagatggat acaggtgata ctatcaacca     1680

aagcaccctg ccctcacagc agaaccgttt cccagactac cttgaagcca ttcctgggac     1740

aaatgtggac cttggaacac tggaaggaga tggaatgaac atagaaggag aggagctgat     1800

gccaagtctg caggaagctt tgagttctga catccttaat gacatggagt ctgttttggc     1860

tgccaccaag ctagataaag aaagctttct tacatggtta tagagccctc aggcagactg     1920

aattctaaat ctgtgaagga tctaaggaga cacatgcacc ggaaatttcc ataagccagt     1980

tgcagttttc aggctaatac agaaaaagat gaacaaacgt ccagcaagat actttaatcc     2040

tctattttgc tcttccttgt ccattgctgc tgttaatgta ttgctgacct ctttcacagt     2100

tggctctaaa gaatcaaaag aaaaaaactt tttatttctt ttgctattaa aactactgtt     2160

cattttgggg gctgggggaa gtgagcctgt ttggatgatg gatgccattc cttttgccca     2220

gttaaatgtt caccaatcat tttaactaaa tactcagact tagaagtcag atgcttcatg     2280

tcacagcatt tagtttgttc aacagttgtt tcttcagctt cctttgtcca gtggaaaaac     2340

atgatttact ggtctgacaa gccaaaaatg ttatatctga tattaaatac ttaatgctga     2400

tttgaagaga tagctgaaac caaggctgaa gactgtttta ctttcagtat tttcttttcc     2460

tcctagtgct atcattagtc acataatgac cttgatttta ttttaggagc ttataaggca     2520

tgagacaatt tccatataaa tatattaatt attgccacat actctaatat agattttggt     2580

ggataatttt gtgggtgtgc attttgttct gttttgttgg gttttttgtt ttttttgttt     2640

ttggcagggt cggtgggggg gttggttggt tggttggttt tgtcggaacc taggcaaatg     2700

accatattag tgaatctgtt aatagttgta gcttgggatg gttattgtag ttgttttggt     2760

aaaatcttca tttcctggtt ttttttacca ccttatttaa atctcgatta tctgctctct     2820

cttttatata catacacaca cccaaacata acatttataa tagtgtggta gtggaatgta     2880

tcctttttta ggtttccctg ctttccagtt aatttttaaa atggtagcgc tttgtatgca     2940

tttagaatac atgactagta gtttatattt cactggtagt ttaaatctgg ttggggcagt     3000

ctgcagatgt ttgaagtagt ttagtgttct agaaagagct attactgtgg atagtgccta     3060

ggggagtgct ccacgccctc tgggcatacg gtagatatta tctgatgaat tggaaaggag     3120

caaaccagaa atggctttat tttctccctt ggactaattt ttaagtctcg attggaattc     3180

agtgagtagg ttcataatgt gcatgacaga aataagcttt atagtggttt accttcattt     3240

agctttggaa gttttctttg ccttagtttt ggaagtaaat tctagtttgt agttctcatt     3300

tgtaatgaac acattaacga ctagattaaa atattgcctt caagattgtt cttacttaca     3360

agacttgctc ctacttctat gctgaaaatt gaccctggat agaatactat aaggttttga     3420

gttagctgga aaagtgatca gattaataaa tgtatattgg tagttgaatt tagcaaagaa     3480

atagagataa tcatgattat acctttattt ttacaggaag agatgatgta actagagtat     3540

gtgtctacag gagtaataat ggtttccaaa gagtattttt taaaggaaca aaacgagcat     3600

gaattaactc ttcaatataa gctatgaagt aatagttggt tgtgaattaa agtggcacca     3660

gctagcacct ctgtgtttta agggtctttc aatgtttcta gaataagccc ttattttcaa     3720

gggttcataa caggcataaa atctcttctc ctggcaaaag ctgctatgaa aagcctcagc     3780

ttgggaagat agattttttt ccccccaatt acaaaatcta agtattttgg cccttcaatt     3840

tggaggaggg caaaagttgg aagtaagaag ttttatttta agtactttca gtgctcaaaa     3900

aaatgcaatc actgtgttgt atataatagt tcataggttg atcactcata ataattgact     3960

ctaaggcttt tattaagaaa acagcagaaa gattaaatct tgaattaagt ctggggggaa     4020

atggccactg cagatggagt tttagagtag taatgaaatt ctacctagaa tgcaaaattg     4080

ggtatatgaa ttacatagca tgttgttggg atttttttta atgtgcagaa gatcaaagct     4140

acttggaagg agtgcctata atttgccagt agccacagat taagattata tcttatatat     4200

cagcagatta gctttagctt agggggaggg tgggaaagtt tggggggggg gttgtgaaga     4260

tttaggggga ccttgataga gaactttata aacttctttc tctttaataa agacttgtct     4320

tacaccgtgc tgccattaaa ggcagctgtt ctagagtttc agtcacctaa gtacacccac     4380

aaaacaatat gaatatggag atcttccttt acccctcaac tttaatttgc ccagttatac     4440

ctcagtgttg tagcagtact gtgatacctg gcacagtgct ttgatcttac gatgccctct     4500

gtactgacct gaaggagacc taagagtcct ttcccttttt gagtttgaat catagccttg     4560

atgtggtctc ttgttttatg tccttgttcc taatgtaaaa gtgcttaact gcttcttggt     4620

tgtattgggt agcattggga taagatttta actgggtatt cttgaattgc ttttacaata     4680

aaccaatttt ataatcttta aatttatcaa ctttttacat ttgtgttatt ttcagtcagg     4740

gcttcttaga tctacttatg gttgatggag cacattgatt tggagtttca gatcttccaa     4800

agcactattt gttgtaataa cttttctaaa tgtagtgcct ttaaaggaaa aatgaacaca     4860

gggaagtgac tttgctacaa ataatgttgc tgtgttaagt attcatatta aatacatgcc     4920

ttctatatgg aacatggcag aaagactgaa aaataacagt aattaattgt gtaattcaga     4980

attcatacca atcagtgttg aaactcaaac attgcaaaag tgggtggcaa tattcagtgc     5040

ttaacacttt tctagcgttg gtacatctga gaaatgagtg ctcaggtgga ttttatcctc     5100

gcaagcatgt tgttataaga attgtgggtg tgcctatcat aacaattgtt ttctgtatct     5160

tgaaaaagta ttctccacat tttaaatgtt ttatattaga gaattcttta atgcacactt     5220

gtcaaatata tatatatagt accaatgtta cctttttatt ttttgtttta gatgtaagag     5280

catgctcata tgttaggtac ttacataaat tgttacatta ttttttctta tgtaatacct     5340

ttttgtttgt ttatgtggtt caaatatatt ctttccttaa actcttaaaa aaaaaa         5396


<210>  8
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met 
225                 230                 235                 240 


Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr 
                245                 250                 255     


Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg 
            260                 265                 270         


Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln 
        275                 280                 285             


Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln 
    290                 295                 300                 


Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu 
305                 310                 315                 320 


Lys Gln Gln Glu Leu Leu Arg Gln Ala Met Arg Asn Ile Asn Pro Ser 
                325                 330                 335     


Thr Ala Asn Ser Pro Lys Cys Gln Glu Leu Ala Leu Arg Ser Gln Leu 
            340                 345                 350         


Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro 
        355                 360                 365             


Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro 
    370                 375                 380                 


Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp Ser 
385                 390                 395                 400 


Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe 
                405                 410                 415     


Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser 
            420                 425                 430         


Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile 
        435                 440                 445             


Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn 
    450                 455                 460                 


Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser 
465                 470                 475                 480 


Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
                485                 490                 495     


Lys Glu Ser Phe Leu Thr Trp Leu 
            500                 


<210>  9
<211>  9599
<212>  DNA
<213>  Homo sapiens

<400>  9
cgaagatggc ggcgtcgcgt cgctctcagc atcatcacca ccatcatcaa caacagctcc       60

agcccgcccc aggggcttca gcgccgccgc cgccacctcc tcccccactc agccctggcc      120

tggccccggg gaccacccca gcctctccca cggccagcgg cctggccccc ttcgcctccc      180

cgcggcacgg cctagcgctg ccggaggggg atggcagtcg ggatccgccc gacaggcccc      240

gatccccgga cccggttgac ggtaccagct gttgcagtac caccagcaca atctgtaccg      300

tcgccgccgc tcccgtggtc ccagcggttt ctacttcatc tgccgctggg gtcgctccca      360

acccagccgg cagtggcagt aacaattcac cgtcgtcctc ttcttccccg acttcttcct      420

catcttcctc tccatcctcc cctggatcga gcttggcgga gagccccgag gcggccggag      480

ttagcagcac agcaccactg gggcctgggg cagcaggacc tgggacaggg gtcccagcag      540

tgagcggggc cctacgggaa ctgctggagg cctgtcgcaa tggggacgtg tcccgggtaa      600

agaggctggt ggacgcggca aacgtaaatg caaaggacat ggccggccgg aagtcttctc      660

ccctgcactt cgctgcaggt tttggaagga aggatgttgt agaacactta ctacagatgg      720

gtgctaatgt ccacgctcgt gatgatggag gtctcatccc gcttcataat gcctgttctt      780

ttggccatgc tgaggttgtg agtctgttat tgtgccaagg agctgatcca aatgccaggg      840

ataactggaa ctatacacct ctgcatgaag ctgctattaa agggaagatc gatgtgtgca      900

ttgtgctgct gcagcacgga gctgacccaa acattcggaa cactgatggg aaatcagccc      960

tggacctggc agatccttca gcaaaagctg tccttacagg tgaatacaag aaagacgaac     1020

tcctagaagc tgctaggagt ggtaatgaag aaaaactaat ggctttactg actcctctaa     1080

atgtgaattg ccatgcaagt gatgggcgaa agtcgactcc tttacatcta gcagcgggct     1140

acaacagagt tcgaatagtt cagcttcttc ttcagcatgg tgctgatgtt catgcaaaag     1200

acaaaggtgg acttgtgcct cttcataatg catgttcata tggacattat gaagtcacag     1260

aactgctact aaagcatgga gcttgtgtta atgccatgga tctctggcag tttactccac     1320

tgcacgaggc tgcttccaag aaccgtgtag aagtctgctc tttgttactt agccatggcg     1380

ctgatcctac attagtcaac tgccatggca aaagtgctgt ggatatggct ccaactccgg     1440

agcttaggga gagattgact tatgaattta aaggtcattc tttactacaa gcagccagag     1500

aagcagactt agctaaagtt aaaaaaacac tcgctctgga aatcattaat ttcaaacaac     1560

cgcagtctca tgaaacagca ctgcactgtg ctgtggcctc tctgcatccc aaacgtaaac     1620

aagtgacaga attgttactt agaaaaggag caaatgttaa tgaaaaaaat aaagatttca     1680

tgactcccct gcatgttgca gccgaaagag cccataatga tgtcatggaa gttctgcata     1740

agcatggcgc caagatgaat gcactggaca cccttggtca gactgctttg catagagccg     1800

ccctagcagg ccacctgcag acctgccgcc tcctgctgag ttacggctct gacccctcca     1860

tcatctcctt acaaggcttc acagcagcac agatgggcaa tgaagcagtg cagcagattc     1920

tgagtgagag tacacctata cgtacttctg atgttgatta tcgactctta gaggcatcta     1980

aagctggaga cttggaaact gtgaagcaac tttgcagctc tcaaaatgtg aattgtagag     2040

acttagaggg ccggcattcc acgcccttac acttcgcagc aggctacaac cgcgtgtctg     2100

ttgtagagta cctgctacac cacggtgccg atgtccatgc caaagacaag ggtggcttgg     2160

tgccccttca taatgcctgt tcatatggac actatgaggt ggctgagctt ttagtaaggc     2220

atggggcttc tgtcaatgtg gcggacttat ggaaatttac ccctctccat gaagcagcag     2280

ctaaaggaaa gtatgaaatc tgcaagctcc ttttaaaaca tggagcagat ccaactaaaa     2340

agaacagaga tggaaataca cctttggatt tggtaaagga aggagacaca gatattcagg     2400

acttactgag aggggatgct gctttgttgg atgctgccaa gaagggctgc ctggcaagag     2460

tgcagaagct ctgtacccca gagaatatca actgcagaga cacccagggc agaaattcaa     2520

cccctctgca cctggcagca ggctataata acctggaagt agctgaatat cttctagagc     2580

atggagctga tgttaatgcc caggacaagg gtggtttaat tcctcttcat aatgcggcat     2640

cttatgggca tgttgacata gcggctttat tgataaaata caacacgtgt gtaaatgcaa     2700

cagataagtg ggcgtttact cccctccatg aagcagccca gaaaggaagg acgcagctgt     2760

gcgccctcct cctagcgcat ggtgcagacc ccaccatgaa gaaccaggaa ggccagacgc     2820

ctctggatct ggcaacagct gacgatatca gagctttgct gatagatgcc atgcccccag     2880

aggccttacc tacctgtttt aaacctcagg ctactgtagt gagtgcctct ctgatctcac     2940

cagcatccac cccctcctgc ctctcggctg ccagcagcat agacaacctc actggccctt     3000

tagcagagtt ggccgtagga ggagcctcca atgcagggga tggcgccgcg ggaacagaaa     3060

ggaaggaagg agaagttgct ggtcttgaca tgaatatcag ccaatttcta aaaagccttg     3120

gccttgaaca ccttcgggat atctttgaaa cagaacagat tacactagat gtgttggctg     3180

atatgggtca tgaagagttg aaagaaatag gcatcaatgc atatgggcac cgccacaaat     3240

taatcaaagg agtagaaaga ctcttaggtg gacaacaagg caccaatcct tatttgactt     3300

ttcactgtgt taatcaggga acgattttgc tggatcttgc tccagaagat aaagaatatc     3360

agtcagtgga agaagagatg caaagtacta ttcgagaaca cagagatggt ggtaatgctg     3420

gcggcatctt caacagatac aatgtcattc gaattcaaaa agttgtcaac aagaagttga     3480

gggagcggtt ctgccaccga cagaaggaag tgtctgagga gaatcacaac catcacaatg     3540

agcgcatgtt gtttcatggt tctcctttca ttaatgccat tattcataaa gggtttgatg     3600

agcgacatgc atacatagga ggaatgtttg gggccgggat ttattttgct gaaaactcct     3660

caaaaagcaa ccaatatgtt tatggaattg gaggaggaac aggctgccct acacacaagg     3720

acaggtcatg ctatatatgt cacagacaaa tgctcttctg tagagtgacc cttgggaaat     3780

cctttctgca gtttagcacc atgaaaatgg cccacgcgcc tccagggcac cactcagtca     3840

ttggtagacc gagcgtcaat gggctggcat atgctgaata tgtcatctac agaggagaac     3900

aggcataccc agagtatctt atcacttacc agatcatgaa gccagaagcc ccttcccaga     3960

ccgcaacagc cgcagagcag aagacctagt gaatgcctgc tggtgaaggc cagatcagat     4020

ttcaacctgg gactggatta cagaggattg tttctaataa caacatcaat attctagaag     4080

tccctgacag cctagaaata agctgtttgt cttctataaa gcattgctat agtgatgaat     4140

agtatgagta actgatacat actcaactgc tactgttccc tttgaggaaa tgtttacagg     4200

ggcggccttt taacatatct caggctcatt ttcattgcaa ttatccattt ctaaaacaag     4260

attgcttcga tctagacttg gaaatggaaa ataagaaaac caatgctttt tcaaatgttc     4320

acaattcaca cactacattt gttttgttat gcatgacgtg tctataacaa atatacacat     4380

acgacaggca acaagcttgt ttttgatttg ccagacatgc atcattggct attgtttgtt     4440

tgttttttgt ttttttgtgt tttttgggtt actttgaaaa tgagccagag ccttcttgag     4500

gatattttgc acaaagtcac gctgacaaaa tcattagcag tgcaacccaa gcttctggct     4560

gagcaagatt cagtttccac tttttaaaat ttttttattt tgctctgtag ctgcacttct     4620

cgttatcata aattgagatg aaaaggaaaa aacatcaagt tttagtacct ttttatgaat     4680

tggcctatct tacaagagaa gggcacaaac accaacctga cttaggaacg cctaaattca     4740

gagaagtcaa agccggtgaa ggccacttgc tctttccaac acaagcctgc cacagaggtc     4800

ttcgggacag tactggagat gcaggttgac acgggcttga gttccaaggt gaaaaaactg     4860

gggaggctgt gaaggaagag ctgcattaag gagggtgagg agcgtgtggt tctgtatcat     4920

ggcagcccca atggatccag gggatgcctc caaaaaatac atgcttccct tcccttaatc     4980

tgtactgttg ggattgttac ccctccaaat tagctgcctt atttcaaaag tcagtgaaat     5040

tactgcactt gatgagggtc acaaaaatac cacttgattg tttctttagt tgagaatgct     5100

gggattcaga ctcgaatagt ggatagatac acacaaatgc aaggactttt ttgtttactc     5160

cagatttggg gtttattttg agtggcatgc ttcaaatagt tcataaagat ccttgcatta     5220

aatttctgaa ccatttcttc aaacttctta gtgtgtttag acaaggagaa caaaaattga     5280

aaccaaagcc ctttctgtta ttttttcaat gaaggtgaga aagaaatacc atacaatttt     5340

ctttgtgaaa ttactgttta ttttcatcaa catttaccaa gtgccattga catttataaa     5400

aaaaaatgat cctttatagt tcttacactt gcccttttca ccttaactga atatgaattg     5460

agtgcactaa cttatttact tgatatactg tgcatctact ctgctttgaa gcgaaagaaa     5520

tataaacacg aggaggaata ggaaagacag tgtgacacaa acttgccatt gcaattcaaa     5580

gccctgaaaa cgatgggttt aatgcaaggt gattaagctg tgacctcctt taatctcctg     5640

aagcaaaata aaatggttac atgcaaaact tctagaaata gactcttaaa atatatacat     5700

tttgctttga ttttggcttc aacccagtgc tggaactagg catccagact agtttgaatg     5760

tttgtagctg aatttttatg ggtcctcaaa attaaatcga gaattagcct cagttgttgc     5820

ttcttttgaa gtttcagtga cccaagctgg gtgtttgtgt cttggctact tgtttaatag     5880

cactagaatt ccaggtgaag ctttgagagt tgatattcat taagagggct ttttttcccc     5940

ttctttcctt ctcttttgct gtaacaaagg gttgaagaaa ttgccatctg tgtagttttc     6000

agtagctgtc aagtgtgtct tacttacctt cccccagacg tagtttaaaa tggtaaacac     6060

agctgtgatt tttagttaag taaaagagtt aatatgatat agatatggaa agctttatgg     6120

cttcattaaa aagataaacc actacctaac tgtggttgta tgttgtttcc atcatactaa     6180

ctagatgaat ggatgcgcca gttttcatct tggtccttac acttgagaag ttaaactgtg     6240

gttcagtatt taaactgcca gtgttatacg tctcatgctc tgtgtgccag gtgaaggtac     6300

tgtgtaagga agacatttgc ggtgcttctt gtcctataat gattcaagta tatagtagtt     6360

cttgaaagag tgtgcatata ttactcatct gcttaagaga gtgggttaat ggatatatca     6420

gaggagccaa atacattttt ttcagaactt gaaaaccaaa ggtcatcatg agtgcactca     6480

aaagttagga caagtttatt acatttggga ttttcatctg tagccgtatg aagaaccctt     6540

tccaatataa aagcatggca ttaaattagg ctgaagtctt ttattttttg tatatgtact     6600

atatagaaat actagcaagt taggatcatc caatatggcc taccccgaaa tggcccctct     6660

gtttccctaa ccacatggaa gaaagaatct gaacgtctcc accggctcta cccgagttcc     6720

aaaactaaag ggcttctcca gacctgatgg ttccagttta cctgctgttg gcctgctgga     6780

tacttgactc aggcataaat taagtgccct ggtcccgaac tttctccctg tatttgacct     6840

ccttccctct ttcctaaatt actagtctgg aattaaaatt agctccagca atgacctttg     6900

actccattca ttttctcctc atcttgggtc ttaaaaaagg agaccagata cctcctagct     6960

tttgtatcac aaccaggaat gggtattagg cctcatgcgc tttgctcaga acactgccgc     7020

tttgttaaca aatgacagca tggaacccag agttttgatt cgatgcaaaa taacagcagt     7080

gcaaccagga ttcttgtttt ccttttcctt cttggagttt ggaatttcta gcttttcaag     7140

cagcataagt agaatcaaca ttaggatgtt ttcatgaaat agcatcctta tacttctttg     7200

agcttgatgt tagtggctag actgatttcc ctttgctctc aaaatacaaa gtgcattgaa     7260

gtatacagag aaatgcctga atatggcaag caaataatgt agattaacat tctattattg     7320

tatccgtttt acaaaaaata aaattttgat atatgccgga gaacggcatt agaatgcaat     7380

aagttgtcta ggtttttctg tttcagtgtc tctcccaatg gcacgaaggg ttattgggca     7440

ttgtccccac ccccgccttt ttaacatgtg cactatctgg attcctgtaa atggccttgc     7500

aaacagaagt ggtgtgtatt ttcaagcacc tttcccccat tgtatccgaa tccctcttgt     7560

gtgatatctg tgacaaatag ccttcttctt gtgttttctg ttggactaat tgtctcacgt     7620

aaagctatag accttactaa tttggcaggt attcaaaact gccattaaga taggatttca     7680

tgtcagatac gtatttaaag agtaaagtca aatttgttta atgtcagatc agtgacagaa     7740

gtgaaaagaa agtaattgtg aaagtgatgt ttgagctatt gtacacatct agcatatgga     7800

aagcaaatgc actcgaaaac tactattcta gaacatgagg cttcttcagc aacttgtgca     7860

ctctgccatt aataaattaa atttttcccc tctagaaagc cttaactatg gcggaaactt     7920

tttaaccttt tatattttaa taaataaaac attgtagtcc catttcttag tgtttgaaag     7980

gtgtgtcagt gagtcggcca tgtctccatg tgtttcagac ctgttcatct tattttatga     8040

tggtatattt cataagtaat attcccttac atgcaatgga gctgattaaa attaatccat     8100

ttcaatttct ccatattgga acttcctcag ctaccagatt tctggtttgg agaagtgctg     8160

gaaagatttc aaagcctatt cagttgtgta tgtggggata cgacagcaac tgtgatacct     8220

tgtagaatat gagtgatatg caagctgtgt tttttaattg ttttaaaatg taaattatgg     8280

ttatgctaaa gtgaaaacct agaggaagct aatgatttta tatactttgc acgaccaaat     8340

atggtcgtag tatgacgagt tttatacatt gccagagagt tctgcctcct ctgaaataac     8400

attcgcactg tagattgcat ttcggctttt cctcctttca cattcttttt tgctttacac     8460

ttcacgtctt cgcacctgcc ctacctccca tcctttcaaa gaggtttctt tcacgttcca     8520

gaattcagat tgttctgtga tttcttttac atcagtctac ccatttctgc aggcagccct     8580

gaaagccctt gtgttgattc agagtgtttg cagagaaatg cagttgaacc ctggtagtgg     8640

ggtgtccctc acacacccgc gcacccctcc caaagttcag gatgaaaggc tagaaaaccc     8700

attcaaagtt aggaaagaac acagatcttt gaggccgata gcctagacct agaagatgac     8760

cttgagtatg taaacattgt ctccgtgaca caaaacactg aaactcttca tgtgcatata     8820

acacctgctt ctgctcccat tgtttcaagc tcatcttatc tttgtagtag taatgtttgt     8880

ctttgatacc tacaaactaa aaaggtactt ttatcaaggt ttctcaaaac atttacaaaa     8940

ccagctttga gaaaatgtta tgttgcctgg caacagcact cggagtagta attgtgtttt     9000

ctcattgtga tgttggtctg tgtgagcaac cagtgtagtg actctttggt tcattattcg     9060

tgttgttttt atttttagtc tctgtgtgac ccaacagtgg caggggttac aaccccctct     9120

cctttctttt ttgtatttat ctatttgtag gattgtcaga tcaagtacaa gatgcccagt     9180

taagtttgaa tttcagagaa acaatttcac gttaagaatg tttcatgcaa tatttggcat     9240

atatttacag taaaagcatt cattatttgt ctgaaattca aatttaactg agcatgctgg     9300

tttttctcat tgtttggttt ttctaaatct ggcaatccta cagctgtggt catgggaaat     9360

cacctacagc atgttaaagt cctctagtca tcatctcgtc acctgaaatg gaagtccttt     9420

ttccctcacc ctccacttct ttccaaagga gggcatcaag gaacttaacc tgcctgcctg     9480

gtgggtttct atttaagaca tctttgtgat tatatttaac ctgcaattgt gctttggctt     9540

aatgtctagc tcactgtact tgtaaatgat taatattcaa taaaaccatt tttaaagta      9599


<210>  10
<211>  1327
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Ser Arg Arg Ser Gln His His His His His His Gln Gln 
1               5                   10                  15      


Gln Leu Gln Pro Ala Pro Gly Ala Ser Ala Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Leu Ser Pro Gly Leu Ala Pro Gly Thr Thr Pro Ala Ser Pro 
        35                  40                  45              


Thr Ala Ser Gly Leu Ala Pro Phe Ala Ser Pro Arg His Gly Leu Ala 
    50                  55                  60                  


Leu Pro Glu Gly Asp Gly Ser Arg Asp Pro Pro Asp Arg Pro Arg Ser 
65                  70                  75                  80  


Pro Asp Pro Val Asp Gly Thr Ser Cys Cys Ser Thr Thr Ser Thr Ile 
                85                  90                  95      


Cys Thr Val Ala Ala Ala Pro Val Val Pro Ala Val Ser Thr Ser Ser 
            100                 105                 110         


Ala Ala Gly Val Ala Pro Asn Pro Ala Gly Ser Gly Ser Asn Asn Ser 
        115                 120                 125             


Pro Ser Ser Ser Ser Ser Pro Thr Ser Ser Ser Ser Ser Ser Pro Ser 
    130                 135                 140                 


Ser Pro Gly Ser Ser Leu Ala Glu Ser Pro Glu Ala Ala Gly Val Ser 
145                 150                 155                 160 


Ser Thr Ala Pro Leu Gly Pro Gly Ala Ala Gly Pro Gly Thr Gly Val 
                165                 170                 175     


Pro Ala Val Ser Gly Ala Leu Arg Glu Leu Leu Glu Ala Cys Arg Asn 
            180                 185                 190         


Gly Asp Val Ser Arg Val Lys Arg Leu Val Asp Ala Ala Asn Val Asn 
        195                 200                 205             


Ala Lys Asp Met Ala Gly Arg Lys Ser Ser Pro Leu His Phe Ala Ala 
    210                 215                 220                 


Gly Phe Gly Arg Lys Asp Val Val Glu His Leu Leu Gln Met Gly Ala 
225                 230                 235                 240 


Asn Val His Ala Arg Asp Asp Gly Gly Leu Ile Pro Leu His Asn Ala 
                245                 250                 255     


Cys Ser Phe Gly His Ala Glu Val Val Ser Leu Leu Leu Cys Gln Gly 
            260                 265                 270         


Ala Asp Pro Asn Ala Arg Asp Asn Trp Asn Tyr Thr Pro Leu His Glu 
        275                 280                 285             


Ala Ala Ile Lys Gly Lys Ile Asp Val Cys Ile Val Leu Leu Gln His 
    290                 295                 300                 


Gly Ala Asp Pro Asn Ile Arg Asn Thr Asp Gly Lys Ser Ala Leu Asp 
305                 310                 315                 320 


Leu Ala Asp Pro Ser Ala Lys Ala Val Leu Thr Gly Glu Tyr Lys Lys 
                325                 330                 335     


Asp Glu Leu Leu Glu Ala Ala Arg Ser Gly Asn Glu Glu Lys Leu Met 
            340                 345                 350         


Ala Leu Leu Thr Pro Leu Asn Val Asn Cys His Ala Ser Asp Gly Arg 
        355                 360                 365             


Lys Ser Thr Pro Leu His Leu Ala Ala Gly Tyr Asn Arg Val Arg Ile 
    370                 375                 380                 


Val Gln Leu Leu Leu Gln His Gly Ala Asp Val His Ala Lys Asp Lys 
385                 390                 395                 400 


Gly Gly Leu Val Pro Leu His Asn Ala Cys Ser Tyr Gly His Tyr Glu 
                405                 410                 415     


Val Thr Glu Leu Leu Leu Lys His Gly Ala Cys Val Asn Ala Met Asp 
            420                 425                 430         


Leu Trp Gln Phe Thr Pro Leu His Glu Ala Ala Ser Lys Asn Arg Val 
        435                 440                 445             


Glu Val Cys Ser Leu Leu Leu Ser His Gly Ala Asp Pro Thr Leu Val 
    450                 455                 460                 


Asn Cys His Gly Lys Ser Ala Val Asp Met Ala Pro Thr Pro Glu Leu 
465                 470                 475                 480 


Arg Glu Arg Leu Thr Tyr Glu Phe Lys Gly His Ser Leu Leu Gln Ala 
                485                 490                 495     


Ala Arg Glu Ala Asp Leu Ala Lys Val Lys Lys Thr Leu Ala Leu Glu 
            500                 505                 510         


Ile Ile Asn Phe Lys Gln Pro Gln Ser His Glu Thr Ala Leu His Cys 
        515                 520                 525             


Ala Val Ala Ser Leu His Pro Lys Arg Lys Gln Val Thr Glu Leu Leu 
    530                 535                 540                 


Leu Arg Lys Gly Ala Asn Val Asn Glu Lys Asn Lys Asp Phe Met Thr 
545                 550                 555                 560 


Pro Leu His Val Ala Ala Glu Arg Ala His Asn Asp Val Met Glu Val 
                565                 570                 575     


Leu His Lys His Gly Ala Lys Met Asn Ala Leu Asp Thr Leu Gly Gln 
            580                 585                 590         


Thr Ala Leu His Arg Ala Ala Leu Ala Gly His Leu Gln Thr Cys Arg 
        595                 600                 605             


Leu Leu Leu Ser Tyr Gly Ser Asp Pro Ser Ile Ile Ser Leu Gln Gly 
    610                 615                 620                 


Phe Thr Ala Ala Gln Met Gly Asn Glu Ala Val Gln Gln Ile Leu Ser 
625                 630                 635                 640 


Glu Ser Thr Pro Ile Arg Thr Ser Asp Val Asp Tyr Arg Leu Leu Glu 
                645                 650                 655     


Ala Ser Lys Ala Gly Asp Leu Glu Thr Val Lys Gln Leu Cys Ser Ser 
            660                 665                 670         


Gln Asn Val Asn Cys Arg Asp Leu Glu Gly Arg His Ser Thr Pro Leu 
        675                 680                 685             


His Phe Ala Ala Gly Tyr Asn Arg Val Ser Val Val Glu Tyr Leu Leu 
    690                 695                 700                 


His His Gly Ala Asp Val His Ala Lys Asp Lys Gly Gly Leu Val Pro 
705                 710                 715                 720 


Leu His Asn Ala Cys Ser Tyr Gly His Tyr Glu Val Ala Glu Leu Leu 
                725                 730                 735     


Val Arg His Gly Ala Ser Val Asn Val Ala Asp Leu Trp Lys Phe Thr 
            740                 745                 750         


Pro Leu His Glu Ala Ala Ala Lys Gly Lys Tyr Glu Ile Cys Lys Leu 
        755                 760                 765             


Leu Leu Lys His Gly Ala Asp Pro Thr Lys Lys Asn Arg Asp Gly Asn 
    770                 775                 780                 


Thr Pro Leu Asp Leu Val Lys Glu Gly Asp Thr Asp Ile Gln Asp Leu 
785                 790                 795                 800 


Leu Arg Gly Asp Ala Ala Leu Leu Asp Ala Ala Lys Lys Gly Cys Leu 
                805                 810                 815     


Ala Arg Val Gln Lys Leu Cys Thr Pro Glu Asn Ile Asn Cys Arg Asp 
            820                 825                 830         


Thr Gln Gly Arg Asn Ser Thr Pro Leu His Leu Ala Ala Gly Tyr Asn 
        835                 840                 845             


Asn Leu Glu Val Ala Glu Tyr Leu Leu Glu His Gly Ala Asp Val Asn 
    850                 855                 860                 


Ala Gln Asp Lys Gly Gly Leu Ile Pro Leu His Asn Ala Ala Ser Tyr 
865                 870                 875                 880 


Gly His Val Asp Ile Ala Ala Leu Leu Ile Lys Tyr Asn Thr Cys Val 
                885                 890                 895     


Asn Ala Thr Asp Lys Trp Ala Phe Thr Pro Leu His Glu Ala Ala Gln 
            900                 905                 910         


Lys Gly Arg Thr Gln Leu Cys Ala Leu Leu Leu Ala His Gly Ala Asp 
        915                 920                 925             


Pro Thr Met Lys Asn Gln Glu Gly Gln Thr Pro Leu Asp Leu Ala Thr 
    930                 935                 940                 


Ala Asp Asp Ile Arg Ala Leu Leu Ile Asp Ala Met Pro Pro Glu Ala 
945                 950                 955                 960 


Leu Pro Thr Cys Phe Lys Pro Gln Ala Thr Val Val Ser Ala Ser Leu 
                965                 970                 975     


Ile Ser Pro Ala Ser Thr Pro Ser Cys Leu Ser Ala Ala Ser Ser Ile 
            980                 985                 990         


Asp Asn Leu Thr Gly Pro Leu Ala  Glu Leu Ala Val Gly  Gly Ala Ser 
        995                 1000                 1005             


Asn Ala  Gly Asp Gly Ala Ala  Gly Thr Glu Arg Lys  Glu Gly Glu 
    1010                 1015                 1020             


Val Ala  Gly Leu Asp Met Asn  Ile Ser Gln Phe Leu  Lys Ser Leu 
    1025                 1030                 1035             


Gly Leu  Glu His Leu Arg Asp  Ile Phe Glu Thr Glu  Gln Ile Thr 
    1040                 1045                 1050             


Leu Asp  Val Leu Ala Asp Met  Gly His Glu Glu Leu  Lys Glu Ile 
    1055                 1060                 1065             


Gly Ile  Asn Ala Tyr Gly His  Arg His Lys Leu Ile  Lys Gly Val 
    1070                 1075                 1080             


Glu Arg  Leu Leu Gly Gly Gln  Gln Gly Thr Asn Pro  Tyr Leu Thr 
    1085                 1090                 1095             


Phe His  Cys Val Asn Gln Gly  Thr Ile Leu Leu Asp  Leu Ala Pro 
    1100                 1105                 1110             


Glu Asp  Lys Glu Tyr Gln Ser  Val Glu Glu Glu Met  Gln Ser Thr 
    1115                 1120                 1125             


Ile Arg  Glu His Arg Asp Gly  Gly Asn Ala Gly Gly  Ile Phe Asn 
    1130                 1135                 1140             


Arg Tyr  Asn Val Ile Arg Ile  Gln Lys Val Val Asn  Lys Lys Leu 
    1145                 1150                 1155             


Arg Glu  Arg Phe Cys His Arg  Gln Lys Glu Val Ser  Glu Glu Asn 
    1160                 1165                 1170             


His Asn  His His Asn Glu Arg  Met Leu Phe His Gly  Ser Pro Phe 
    1175                 1180                 1185             


Ile Asn  Ala Ile Ile His Lys  Gly Phe Asp Glu Arg  His Ala Tyr 
    1190                 1195                 1200             


Ile Gly  Gly Met Phe Gly Ala  Gly Ile Tyr Phe Ala  Glu Asn Ser 
    1205                 1210                 1215             


Ser Lys  Ser Asn Gln Tyr Val  Tyr Gly Ile Gly Gly  Gly Thr Gly 
    1220                 1225                 1230             


Cys Pro  Thr His Lys Asp Arg  Ser Cys Tyr Ile Cys  His Arg Gln 
    1235                 1240                 1245             


Met Leu  Phe Cys Arg Val Thr  Leu Gly Lys Ser Phe  Leu Gln Phe 
    1250                 1255                 1260             


Ser Thr  Met Lys Met Ala His  Ala Pro Pro Gly His  His Ser Val 
    1265                 1270                 1275             


Ile Gly  Arg Pro Ser Val Asn  Gly Leu Ala Tyr Ala  Glu Tyr Val 
    1280                 1285                 1290             


Ile Tyr  Arg Gly Glu Gln Ala  Tyr Pro Glu Tyr Leu  Ile Thr Tyr 
    1295                 1300                 1305             


Gln Ile  Met Lys Pro Glu Ala  Pro Ser Gln Thr Ala  Thr Ala Ala 
    1310                 1315                 1320             


Glu Gln  Lys Thr 
    1325         


<210>  11
<211>  6274
<212>  DNA
<213>  Homo sapiens

<400>  11
ggctggacgg agctggcagg aggggccttg ccagcttccg ccgccgcgtc gtttcaggac       60

ccggacggcg gattcgcgct gcctccgccg ccgcggggca gccggggggc agggagccca      120

gcgaggggcg cgcgtgggcg cggccatggg actgcgccgg atccggtgac agcagggagc      180

caagcggccc gggccctgag cgcgtcttct ccggggggcc tcgccctcct gctcgcgggg      240

ccggggctcc tgctccggtt gctggcgctg ttgctggctg tggcggcggc caggatcatg      300

tcgggtcgcc gctgcgccgg cgggggagcg gcctgcgcga gcgccgcggc cgaggccgtg      360

gagccggccg cccgagagct gttcgaggcg tgccgcaacg gggacgtgga acgagtcaag      420

aggctggtga cgcctgagaa ggtgaacagc cgcgacacgg cgggcaggaa atccaccccg      480

ctgcacttcg ccgcaggttt tgggcggaaa gacgtagttg aatatttgct tcagaatggt      540

gcaaatgtcc aagcacgtga tgatgggggc cttattcctc ttcataatgc atgctctttt      600

ggtcatgctg aagtagtcaa tctccttttg cgacatggtg cagaccccaa tgctcgagat      660

aattggaatt atactcctct ccatgaagct gcaattaaag gaaagattga tgtttgcatt      720

gtgctgttac agcatggagc tgagccaacc atccgaaata cagatggaag gacagcattg      780

gatttagcag atccatctgc caaagcagtg cttactggtg aatataagaa agatgaactc      840

ttagaaagtg ccaggagtgg caatgaagaa aaaatgatgg ctctactcac accattaaat      900

gtcaactgcc acgcaagtga tggcagaaag tcaactccat tacatttggc agcaggatat      960

aacagagtaa agattgtaca gctgttactg caacatggag ctgatgtcca tgctaaagat     1020

aaaggtgatc tggtaccatt acacaatgcc tgttcttatg gtcattatga agtaactgaa     1080

cttttggtca agcatggtgc ctgtgtaaat gcaatggact tgtggcaatt cactcctctt     1140

catgaggcag cttctaagaa cagggttgaa gtatgttctc ttctcttaag ttatggtgca     1200

gacccaacac tgctcaattg tcacaataaa agtgctatag acttggctcc cacaccacag     1260

ttaaaagaaa gattagcata tgaatttaaa ggccactcgt tgctgcaagc tgcacgagaa     1320

gctgatgtta ctcgaatcaa aaaacatctc tctctggaaa tggtgaattt caagcatcct     1380

caaacacatg aaacagcatt gcattgtgct gctgcatctc catatcccaa aagaaagcaa     1440

atatgtgaac tgttgctaag aaaaggagca aacatcaatg aaaagactaa agaattcttg     1500

actcctctgc acgtggcatc tgagaaagct cataatgatg ttgttgaagt agtggtgaaa     1560

catgaagcaa aggttaatgc tctggataat cttggtcaga cttctctaca cagagctgca     1620

tattgtggtc atctacaaac ctgccgccta ctcctgagct atgggtgtga tcctaacatt     1680

atatcccttc agggctttac tgctttacag atgggaaatg aaaatgtaca gcaactcctc     1740

caagagggta tctcattagg taattcagag gcagacagac aattgctgga agctgcaaag     1800

gctggagatg tcgaaactgt aaaaaaactg tgtactgttc agagtgtcaa ctgcagagac     1860

attgaagggc gtcagtctac accacttcat tttgcagctg ggtataacag agtgtccgtg     1920

gtggaatatc tgctacagca tggagctgat gtgcatgcta aagataaagg aggccttgta     1980

cctttgcaca atgcatgttc ttatggacat tatgaagttg cagaacttct tgttaaacat     2040

ggagcagtag ttaatgtagc tgatttatgg aaatttacac ctttacatga agcagcagca     2100

aaaggaaaat atgaaatttg caaacttctg ctccagcatg gtgcagaccc tacaaaaaaa     2160

aacagggatg gaaatactcc tttggatctt gttaaagatg gagatacaga tattcaagat     2220

ctgcttaggg gagatgcagc tttgctagat gctgccaaga agggttgttt agccagagtg     2280

aagaagttgt cttctcctga taatgtaaat tgccgcgata cccaaggcag acattcaaca     2340

cctttacatt tagcagctgg ttataataat ttagaagttg cagagtattt gttacaacac     2400

ggagctgatg tgaatgccca agacaaagga ggacttattc ctttacataa tgcagcatct     2460

tacgggcatg tagatgtagc agctctacta ataaagtata atgcatgtgt caatgccacg     2520

gacaaatggg ctttcacacc tttgcacgaa gcagcccaaa agggacgaac acagctttgt     2580

gctttgttgc tagcccatgg agctgacccg actcttaaaa atcaggaagg acaaacacct     2640

ttagatttag tttcagcgga tgatgtcagc gctcttctga cagcagccat gcccccatct     2700

gctctgccct cttgttacaa gcctcaagtg ctcaatggtg tgagaagccc aggagccact     2760

gcagatgctc tctcttcagg tccatctagc ccatcaagcc tttctgcagc cagcagtctt     2820

gacaacttat ctgggagttt ttcagaactg tcttcagtag ttagttcaag tggaacagag     2880

ggtgcttcca gtttggagaa aaaggaggtt ccaggagtag attttagcat aactcaattc     2940

gtaaggaatc ttggacttga gcacctaatg gatatatttg agagagaaca gatcactttg     3000

gatgtattag ttgagatggg gcacaaggag ctgaaggaga ttggaatcaa tgcttatgga     3060

cataggcaca aactaattaa aggagtcgag agacttatct ccggacaaca aggtcttaac     3120

ccatatttaa ctttgaacac ctctggtagt ggaacaattc ttatagatct gtctcctgat     3180

gataaagagt ttcagtctgt ggaggaagag atgcaaagta cagttcgaga gcacagagat     3240

ggaggtcatg caggtggaat cttcaacaga tacaatattc tcaagattca gaaggtttgt     3300

aacaagaaac tatgggaaag atacactcac cggagaaaag aagtttctga agaaaaccac     3360

aaccatgcca atgaacgaat gctatttcat gggtctcctt ttgtgaatgc aattatccac     3420

aaaggctttg atgaaaggca tgcgtacata ggtggtatgt ttggagctgg catttatttt     3480

gctgaaaact cttccaaaag caatcaatat gtatatggaa ttggaggagg tactgggtgt     3540

ccagttcaca aagacagatc ttgttacatt tgccacaggc agctgctctt ttgccgggta     3600

accttgggaa agtctttcct gcagttcagt gcaatgaaaa tggcacattc tcctccaggt     3660

catcactcag tcactggtag gcccagtgta aatggcctag cattagctga atatgttatt     3720

tacagaggag aacaggctta tcctgagtat ttaattactt accagattat gaggcctgaa     3780

ggtatggtcg atggataaat agttatttta agaaactaat tccactgaac ctaaaatcat     3840

caaagcagca gtggcctcta cgttttactc ctttgctgaa aaaaaatcat cttgcccaca     3900

ggcctgtggc aaaaggataa aaatgtgaac gaagtttaac attctgactt gataaagctt     3960

taataatgta cagtgttttc taaatatttc ctgttttttc agcactttaa cagatgccat     4020

tccaggttaa actgggttgt ctgtactaaa ttataaacag agttaacttg aaccttttat     4080

atgttatgca ttgattctaa caaactgtaa tgccctcaac agaactaatt ttactaatac     4140

aatactgtgt tctttaaaac acagcattta cactgaatac aatttcattt gtaaaactgt     4200

aaataagagc ttttgtacta gcccagtatt tatttacatt gctttgtaat ataaatctgt     4260

tttagaactg cagcggttta caaaattttt tcatatgtat tgttcatcta tacttcatct     4320

tacatcgtca tgattgagtg atctttacat ttgattccag aggctatgtt cagttgttag     4380

ttgggaaaga ttgagttatc agatttaatt tgccgatggg agcctttatc tgtcattaga     4440

aatctttctc atttaagaac ttatgaatat gctgaagatt taatttgtga tacctttgta     4500

tgtatgagac acattccaaa gagctctaac tatgataggt cctgattact aaagaagctt     4560

ctttactggc ctcaatttct agctttcatg ttggaaaatt ttctgcagtc cttctgtgaa     4620

aattagagca aagtgctcct gttttttaga gaaactaaat cttgctgttg aacaattatt     4680

gtgttctttt catggaacat aagtaggatg ttacatttcc agggtgggaa gggtaatcct     4740

aaatcatttc ccaatctatt ctaattacct taaatctaaa ggggaaaaaa aaaatcacaa     4800

acaggactgg gtagtttttt atcctaagta tattttttcc tgttcttttt acttggtttt     4860

attgctgtat ttatagccaa tctatacatc atgggtaaac ttaacccaga actataaaat     4920

gtagttgtct cagtcccctc caggcctcct gaatgggcaa gtgcagtgaa acaggtgctt     4980

cttgctcctg ggttttctct ccatgatgtt atgcccaatt ggaaatatgc tgtcagtttg     5040

tgcaccatat ggtgaccacg cctgtgctca gtttggcagc tatagaagga aatgctgtcc     5100

cataaaatgc cattcctatt ttctaatata aaactctttt ccaggaagca tgcttaagca     5160

tcttgttaca gagacataca tccattatgg cttggcaatc tcttttattt gttgactcta     5220

gctcccttca aagtcgagga aagatcttta ctcacttaat gaggacattc cccatcactg     5280

tctgtaccag ttcaccttta ttttacgttt tattcagtct gtaaattaac tggccctttg     5340

cagtaacttg tacataaagt gctagaaaat catgttcctt gtcctgagta agagttaatc     5400

agagtaaatg catttctgga gttgtttctg tgatgtaaat tatgatcatt atttaagaag     5460

tcaaatcctg atcttgaagt gctttttata cagctctcta ataattacaa atatccgaaa     5520

gtcatttctt ggaacacaag tggagtatgc caaattttat atgaattttt cagattatct     5580

aagcttccag gttttataat tagaagataa tgagagaatt aatggggttt atatttacat     5640

tatctctcaa ctatgtagcc catattactc accctatgag tgaatctgga attgcttttc     5700

atgtgaaatc attgtggtct atgagtttac aatactgcaa actgtgttat tttatctaat     5760

ccattgctta atgagtgtgt ttttccatga atgaatatac cgtggttcat atgttagcat     5820

ggcagcattt tcagatagct ttttgtttgt tgggaagttg gggttttggg gggaggggga     5880

gtattagtac gttgcatgaa atagcttact ttataatgat ggaattgctt tttcttttgt     5940

cttgtgattt ttttttttga agtgaaattt aactttttgt gcaagtagta ctattatacc     6000

catcttcagt gtcttacttg tactgtatca cattccatac cctcatttaa ttcttaataa     6060

aactgttcac ttgtttttct gggtagcatg gtaattactg gaatagtata aatgtgttga     6120

atggtctttg agaaaatgaa ttaagattac aataaaccac aattgcagga aaacaatgta     6180

gttctgagtc taatagtgat aaagaatgca gtttgaagtt tgaaatattg aatattgtag     6240

ctgtacttgc tcattaaaat gaaagtagct gtga                                 6274


<210>  12
<211>  1166
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Gly Arg Arg Cys Ala Gly Gly Gly Ala Ala Cys Ala Ser Ala 
1               5                   10                  15      


Ala Ala Glu Ala Val Glu Pro Ala Ala Arg Glu Leu Phe Glu Ala Cys 
            20                  25                  30          


Arg Asn Gly Asp Val Glu Arg Val Lys Arg Leu Val Thr Pro Glu Lys 
        35                  40                  45              


Val Asn Ser Arg Asp Thr Ala Gly Arg Lys Ser Thr Pro Leu His Phe 
    50                  55                  60                  


Ala Ala Gly Phe Gly Arg Lys Asp Val Val Glu Tyr Leu Leu Gln Asn 
65                  70                  75                  80  


Gly Ala Asn Val Gln Ala Arg Asp Asp Gly Gly Leu Ile Pro Leu His 
                85                  90                  95      


Asn Ala Cys Ser Phe Gly His Ala Glu Val Val Asn Leu Leu Leu Arg 
            100                 105                 110         


His Gly Ala Asp Pro Asn Ala Arg Asp Asn Trp Asn Tyr Thr Pro Leu 
        115                 120                 125             


His Glu Ala Ala Ile Lys Gly Lys Ile Asp Val Cys Ile Val Leu Leu 
    130                 135                 140                 


Gln His Gly Ala Glu Pro Thr Ile Arg Asn Thr Asp Gly Arg Thr Ala 
145                 150                 155                 160 


Leu Asp Leu Ala Asp Pro Ser Ala Lys Ala Val Leu Thr Gly Glu Tyr 
                165                 170                 175     


Lys Lys Asp Glu Leu Leu Glu Ser Ala Arg Ser Gly Asn Glu Glu Lys 
            180                 185                 190         


Met Met Ala Leu Leu Thr Pro Leu Asn Val Asn Cys His Ala Ser Asp 
        195                 200                 205             


Gly Arg Lys Ser Thr Pro Leu His Leu Ala Ala Gly Tyr Asn Arg Val 
    210                 215                 220                 


Lys Ile Val Gln Leu Leu Leu Gln His Gly Ala Asp Val His Ala Lys 
225                 230                 235                 240 


Asp Lys Gly Asp Leu Val Pro Leu His Asn Ala Cys Ser Tyr Gly His 
                245                 250                 255     


Tyr Glu Val Thr Glu Leu Leu Val Lys His Gly Ala Cys Val Asn Ala 
            260                 265                 270         


Met Asp Leu Trp Gln Phe Thr Pro Leu His Glu Ala Ala Ser Lys Asn 
        275                 280                 285             


Arg Val Glu Val Cys Ser Leu Leu Leu Ser Tyr Gly Ala Asp Pro Thr 
    290                 295                 300                 


Leu Leu Asn Cys His Asn Lys Ser Ala Ile Asp Leu Ala Pro Thr Pro 
305                 310                 315                 320 


Gln Leu Lys Glu Arg Leu Ala Tyr Glu Phe Lys Gly His Ser Leu Leu 
                325                 330                 335     


Gln Ala Ala Arg Glu Ala Asp Val Thr Arg Ile Lys Lys His Leu Ser 
            340                 345                 350         


Leu Glu Met Val Asn Phe Lys His Pro Gln Thr His Glu Thr Ala Leu 
        355                 360                 365             


His Cys Ala Ala Ala Ser Pro Tyr Pro Lys Arg Lys Gln Ile Cys Glu 
    370                 375                 380                 


Leu Leu Leu Arg Lys Gly Ala Asn Ile Asn Glu Lys Thr Lys Glu Phe 
385                 390                 395                 400 


Leu Thr Pro Leu His Val Ala Ser Glu Lys Ala His Asn Asp Val Val 
                405                 410                 415     


Glu Val Val Val Lys His Glu Ala Lys Val Asn Ala Leu Asp Asn Leu 
            420                 425                 430         


Gly Gln Thr Ser Leu His Arg Ala Ala Tyr Cys Gly His Leu Gln Thr 
        435                 440                 445             


Cys Arg Leu Leu Leu Ser Tyr Gly Cys Asp Pro Asn Ile Ile Ser Leu 
    450                 455                 460                 


Gln Gly Phe Thr Ala Leu Gln Met Gly Asn Glu Asn Val Gln Gln Leu 
465                 470                 475                 480 


Leu Gln Glu Gly Ile Ser Leu Gly Asn Ser Glu Ala Asp Arg Gln Leu 
                485                 490                 495     


Leu Glu Ala Ala Lys Ala Gly Asp Val Glu Thr Val Lys Lys Leu Cys 
            500                 505                 510         


Thr Val Gln Ser Val Asn Cys Arg Asp Ile Glu Gly Arg Gln Ser Thr 
        515                 520                 525             


Pro Leu His Phe Ala Ala Gly Tyr Asn Arg Val Ser Val Val Glu Tyr 
    530                 535                 540                 


Leu Leu Gln His Gly Ala Asp Val His Ala Lys Asp Lys Gly Gly Leu 
545                 550                 555                 560 


Val Pro Leu His Asn Ala Cys Ser Tyr Gly His Tyr Glu Val Ala Glu 
                565                 570                 575     


Leu Leu Val Lys His Gly Ala Val Val Asn Val Ala Asp Leu Trp Lys 
            580                 585                 590         


Phe Thr Pro Leu His Glu Ala Ala Ala Lys Gly Lys Tyr Glu Ile Cys 
        595                 600                 605             


Lys Leu Leu Leu Gln His Gly Ala Asp Pro Thr Lys Lys Asn Arg Asp 
    610                 615                 620                 


Gly Asn Thr Pro Leu Asp Leu Val Lys Asp Gly Asp Thr Asp Ile Gln 
625                 630                 635                 640 


Asp Leu Leu Arg Gly Asp Ala Ala Leu Leu Asp Ala Ala Lys Lys Gly 
                645                 650                 655     


Cys Leu Ala Arg Val Lys Lys Leu Ser Ser Pro Asp Asn Val Asn Cys 
            660                 665                 670         


Arg Asp Thr Gln Gly Arg His Ser Thr Pro Leu His Leu Ala Ala Gly 
        675                 680                 685             


Tyr Asn Asn Leu Glu Val Ala Glu Tyr Leu Leu Gln His Gly Ala Asp 
    690                 695                 700                 


Val Asn Ala Gln Asp Lys Gly Gly Leu Ile Pro Leu His Asn Ala Ala 
705                 710                 715                 720 


Ser Tyr Gly His Val Asp Val Ala Ala Leu Leu Ile Lys Tyr Asn Ala 
                725                 730                 735     


Cys Val Asn Ala Thr Asp Lys Trp Ala Phe Thr Pro Leu His Glu Ala 
            740                 745                 750         


Ala Gln Lys Gly Arg Thr Gln Leu Cys Ala Leu Leu Leu Ala His Gly 
        755                 760                 765             


Ala Asp Pro Thr Leu Lys Asn Gln Glu Gly Gln Thr Pro Leu Asp Leu 
    770                 775                 780                 


Val Ser Ala Asp Asp Val Ser Ala Leu Leu Thr Ala Ala Met Pro Pro 
785                 790                 795                 800 


Ser Ala Leu Pro Ser Cys Tyr Lys Pro Gln Val Leu Asn Gly Val Arg 
                805                 810                 815     


Ser Pro Gly Ala Thr Ala Asp Ala Leu Ser Ser Gly Pro Ser Ser Pro 
            820                 825                 830         


Ser Ser Leu Ser Ala Ala Ser Ser Leu Asp Asn Leu Ser Gly Ser Phe 
        835                 840                 845             


Ser Glu Leu Ser Ser Val Val Ser Ser Ser Gly Thr Glu Gly Ala Ser 
    850                 855                 860                 


Ser Leu Glu Lys Lys Glu Val Pro Gly Val Asp Phe Ser Ile Thr Gln 
865                 870                 875                 880 


Phe Val Arg Asn Leu Gly Leu Glu His Leu Met Asp Ile Phe Glu Arg 
                885                 890                 895     


Glu Gln Ile Thr Leu Asp Val Leu Val Glu Met Gly His Lys Glu Leu 
            900                 905                 910         


Lys Glu Ile Gly Ile Asn Ala Tyr Gly His Arg His Lys Leu Ile Lys 
        915                 920                 925             


Gly Val Glu Arg Leu Ile Ser Gly Gln Gln Gly Leu Asn Pro Tyr Leu 
    930                 935                 940                 


Thr Leu Asn Thr Ser Gly Ser Gly Thr Ile Leu Ile Asp Leu Ser Pro 
945                 950                 955                 960 


Asp Asp Lys Glu Phe Gln Ser Val Glu Glu Glu Met Gln Ser Thr Val 
                965                 970                 975     


Arg Glu His Arg Asp Gly Gly His Ala Gly Gly Ile Phe Asn Arg Tyr 
            980                 985                 990         


Asn Ile Leu Lys Ile Gln Lys Val  Cys Asn Lys Lys Leu  Trp Glu Arg 
        995                 1000                 1005             


Tyr Thr  His Arg Arg Lys Glu  Val Ser Glu Glu Asn  His Asn His 
    1010                 1015                 1020             


Ala Asn  Glu Arg Met Leu Phe  His Gly Ser Pro Phe  Val Asn Ala 
    1025                 1030                 1035             


Ile Ile  His Lys Gly Phe Asp  Glu Arg His Ala Tyr  Ile Gly Gly 
    1040                 1045                 1050             


Met Phe  Gly Ala Gly Ile Tyr  Phe Ala Glu Asn Ser  Ser Lys Ser 
    1055                 1060                 1065             


Asn Gln  Tyr Val Tyr Gly Ile  Gly Gly Gly Thr Gly  Cys Pro Val 
    1070                 1075                 1080             


His Lys  Asp Arg Ser Cys Tyr  Ile Cys His Arg Gln  Leu Leu Phe 
    1085                 1090                 1095             


Cys Arg  Val Thr Leu Gly Lys  Ser Phe Leu Gln Phe  Ser Ala Met 
    1100                 1105                 1110             


Lys Met  Ala His Ser Pro Pro  Gly His His Ser Val  Thr Gly Arg 
    1115                 1120                 1125             


Pro Ser  Val Asn Gly Leu Ala  Leu Ala Glu Tyr Val  Ile Tyr Arg 
    1130                 1135                 1140             


Gly Glu  Gln Ala Tyr Pro Glu  Tyr Leu Ile Thr Tyr  Gln Ile Met 
    1145                 1150                 1155             


Arg Pro  Glu Gly Met Val Asp  Gly 
    1160                 1165     


<210>  13
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  13
taagcagcta gcgccacctt ggagggcacg gccggcac                               38


<210>  14
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  14
actatgggat cctcattctt tcaccagcct gtggatgtgg tgctgagc                    48


<210>  15
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  15
ccaatgacaa cgcctcctg                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  16
tggtgcagcc agaaagctc                                                    19


<210>  17
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  17
agcctcgcat cctatacaac c                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  18
ttctttcaca aggcggcact c                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  19
cacttctagc ccaccctgtg a                                                 21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  20
ccacaggttc cgtaatgatt t                                                 21


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  21
tagccctgcg tagccagtta                                                   20


<210>  22
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  22
tcatgcttag tccactgtct gt                                                22


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  23
actaccacca cctccagtca                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  24
acaaggtgac gactctctgc                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  25
gcagacagga aaactgagga                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  26
aaatgtggtg ggaacagaga                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  27
gctactgggg tagcaactga                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  28
gaaggcagtg aggaactgaa                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  29
gacccaaaca ttcggaacac                                                   20


<210>  30
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  30
gcagcttcta ggagttcgtc tt                                                22


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  31
aacgagtcaa gaggctggtg                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  32
ttcaactacg tctttccgcc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  33
ctctgctcct cctgttcgac                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  34
ttaaaagcag ccctggtgac                                                   20


<210>  35
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Asp His His Gln Gln Leu Val Ala His Ala Ala Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu Ile Gln Ser Glu Asn Leu Ile Met Glu Lys Gln Leu 
            20                  25                  30          


<210>  36
<211>  29
<212>  PRT
<213>  Mus musculus

<400>  36

Gln Asp His His Gln Gln Leu Val Ala His Ala Arg Gln Glu Pro Gln 
1               5                   10                  15      


Gly Gln Glu Ile Gln Ser Glu Asn Met Glu Lys Gln Leu 
            20                  25                  


<210>  37
<211>  30
<212>  PRT
<213>  Canis familiaris

<400>  37

Gln Asp His His Gln Gln Leu Val Ala His Ala Ala Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu Ile Gln Glu Asn Ile Met Glu Lys Gln Leu 
            20                  25                  30  


<210>  38
<211>  23
<212>  PRT
<213>  Xenopus

<400>  38

Gln Asp Leu Val His Ala Ala Arg Gln Glu Pro Gln Gly Gln Glu Ile 
1               5                   10                  15      


Gln Glu Asn Met Glu Lys Gln 
            20              


<210>  39
<211>  18
<212>  PRT
<213>  Danio rerio

<400>  39

Asp Glu His Val His Ala Arg Gln Glu Pro Gln Gly Gln Glu Leu Gln 
1               5                   10                  15      


Glu Lys 
        


<210>  40
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  40

Thr Gln Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu His Gln Val Asp Asn Thr Val Met Glu Lys Gln Val 
            20                  25                  30          


<210>  41
<211>  32
<212>  PRT
<213>  Mus musculus

<400>  41

Thr Gln Glu Asp Pro Gln Met Val Tyr Gln Ser Ala Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu His Gln Gly Asp Asn Thr Val Met Glu Lys Gln Val 
            20                  25                  30          


<210>  42
<211>  32
<212>  PRT
<213>  Canis familiaris

<400>  42

Ala Gln Glu Asp Pro Pro Met Val Tyr Gln Ser Ala Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu His Gln Val Asp Asn Thr Val Met Glu Lys Gln Gly 
            20                  25                  30          


<210>  43
<211>  26
<212>  PRT
<213>  Xenopus

<400>  43

Gln Glu Asp Pro Gln Met Val Gln Ser Ala Arg Gln Glu Pro Gln Gly 
1               5                   10                  15      


Gln Glu His Asp Asn Thr Val Met Glu Lys 
            20                  25      


<210>  44
<211>  14
<212>  PRT
<213>  Danio rerio

<400>  44

Arg Gln Glu Pro Gln Gly Gln Glu His Gln Asp Met Glu Lys 
1               5                   10                  


<210>  45
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Pro Glu Asp Ser Gln Val Leu Gln Gln Ala Thr Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu His Gln Gly Gly Glu Asn His Leu Ala Glu Asn Thr 
            20                  25                  30          


<210>  46
<211>  31
<212>  PRT
<213>  Mus musculus

<400>  46

Ala Pro Glu Asp Ser Gln Val Leu Gln Gln Ala Thr Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu His Gln Gly Gly Glu Thr His Leu Ala Glu Asn 
            20                  25                  30      


<210>  47
<211>  32
<212>  PRT
<213>  Canis familiaris

<400>  47

Ala Pro Glu Asp Thr Gln Val Leu Gln Gln Ala Thr Arg Gln Glu Pro 
1               5                   10                  15      


Gln Gly Gln Glu His Gln Gly Gly Glu Ser His Leu Ala Glu Asn Thr 
            20                  25                  30          


<210>  48
<211>  15
<212>  PRT
<213>  Xenopus

<400>  48

Glu Ser Gln Arg Gln Glu Pro Gln Gly Gln Glu His Gln Gly His 
1               5                   10                  15  


<210>  49
<211>  9
<212>  PRT
<213>  Danio rerio

<400>  49

Arg Gln Glu Pro Gln Gly Gln Glu Leu 
1               5                   


