                         SEQUENCE LISTING

<110>  WAYNE STATE UNIVERSITY
 
<120>  TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER

<130>  W063-0048PCT

<150>  US 62/329,703
<151>  2016-04-29

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse S1PR1 Sense

<400>  2
atcatgggct ggaactgcat ca                                                22


<210>  3
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse S1PR1 Antiense

<400>  3
cgagtcctga ccaaggagta gat                                               23


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse S1PR2 sense

<400>  4
cagacgctag ccctgctcaa ga                                                22


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse S1PR2 antisense

<400>  5
tagtgggctt tgtagagga                                                    19


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse S1PR3 sense

<400>  6
acaaccgcat gtactttttc at                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse S1PR3 antisense

<400>  7
tactgccctc cctgaggaac ca                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human S1PR4, sense

<400>  8
gggccatctt ccgcctggtg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human S1PR4, antisense

<400>  9
tgccccgcag gtactcctgg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human S1PR5, sense

<400>  10
ggcgcgcacc tgtcctgtac                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human S1PR5, antisense

<400>  11
tcgggtctct gccgcaggag                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse SphK1, sense

<400>  12
aaacccctgt gtagcctccc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human and mouse SphK1, antisense

<400>  13
agcaggttca tgggtgacag                                                   20


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human SphK2, sense

<400>  14
gcacagcaac agtgagca                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human SphK2, antisense

<400>  15
gagcctgagt gagtggga                                                     18


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  porcine TGF-Beta, sense

<400>  16
gcacgtggag ctataccaga a                                                 21


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  porcine TGF-Beta, antisense

<400>  17
catcaaagga cagccactcc                                                   20


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human GAPDH, sense

<400>  18
gaaggtgaag gtcggagt                                                     18


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human GAPDH, antisense

<400>  19
gaagatggtg atgggtttc                                                    19


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse GAPDH, sense

<400>  20
caccttcgat gccggggctg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse GAPDH, antisense

<400>  21
ggccatgagg tccaccaccc                                                   20


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human Snai1, sense

<400>  22
gaggcggtgg cagactag                                                     18


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human Snai1, antisense

<400>  23
gacacatcgg tcagaccag                                                    19


<210>  24
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse Snai1, sense

<400>  24
ccactgcaac cgtgctttt                                                    19


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse Snai1, antisense

<400>  25
tcttcacatc cgagtggg                                                     18


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE1 F

<400>  26
ccaggttgag ccagtattag                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE1 R

<400>  27
caggcgaacg ggtgctaat                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE2 F

<400>  28
gacacccact agtgcacac                                                    19


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE2 R

<400>  29
gaatgccagc tcataaacg                                                    19


<210>  30
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE3/4 F

<400>  30
cgtttatgag ctggcattc                                                    19


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE3/4 R

<400>  31
ccatcttctc tcaccactcc                                                   20


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE5/6 F

<400>  32
ggagtggtga gagaagatg                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE5/6 R

<400>  33
tccccacaca cgggcctct                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE7 F

<400>  34
cccactgagg acagggatc                                                    19


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE7 R

<400>  35
gcccagaagc cctgaggag                                                    19


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE8 F

<400>  36
gccataaagc atgagagcc                                                    19


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE8 R

<400>  37
gagaaagtca gttaccctg                                                    19


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE9 F

<400>  38
caaccctcag ccagtatcc                                                    19


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE9 R

<400>  39
gcatactgtg gccactgtgt c                                                 21


<210>  40
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE10/11 F

<400>  40
gtaggagtcc aacaaaggg                                                    19


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE10/11 R

<400>  41
acttcgcctg tgctactgtg                                                   20


<210>  42
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE12/13 F

<400>  42
cacagtagca caggcgaag                                                    19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE12/13 R

<400>  43
gccctcagca attgagctg                                                    19


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE14 F

<400>  44
gcaccctgct ccaagagaag                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE14 R

<400>  45
ggccggcagg attgggccgc                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE15 F

<400>  46
ctggctgccg gtctaggagg                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE15 R

<400>  47
ccaggcacgc agagacttgg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE16 F

<400>  48
gaatcggccc aaacaaaccc                                                   20


<210>  49
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SBE16 R

<400>  49
gagctccagg tgcagaaac                                                    19


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P13 sense

<400>  50
gtcagcaggc agagtcactt gc                                                22


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P13 antisense

<400>  51
ctaggcaagt gactctgcct gctgacagct                                        30


<210>  52
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P14 sense

<400>  52
gggcaaaaga cagaaagtaa cc                                                22


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P14 antisense

<400>  53
ctagggttac tttctgtctt ttgcccagct                                        30


<210>  54
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P15 sense

<400>  54
gtgcaccagc agaggctggg gc                                                22


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P15 antisense

<400>  55
ctaggcccca gcctctgctg gtgcacagct                                        30


<210>  56
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scramble P14 sense

<400>  56
gggcaaatgg cgaaaagtaa cc                                                22


<210>  57
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scramble P14 antisense

<400>  57
ctagggttac ttttcgccat ttgcccagct                                        30


