               SEQUENCE LISTING

<110> Global Bioenergies

<120> 3-Methylcrotonic acid decarboxylase (MDC) variants

<130> Z1505 PCT S3

<150> EP 16 19 9502.2
<151> 2016-11-18

<150> EP 16 16 8448.5
<151> 2016-05-04

<160> 13

<170> BiSSAP 1.3

<210> 1
<211> 512
<212> PRT
<213> Hypocrea atroviridis

<220> 
<223> Hypocrea atroviridis (strain ATCC 20476)

<400> 1
Met Ser Ser Thr Thr Tyr Lys Ser Glu Ala Phe Asp Pro Glu Pro Pro 
1               5                   10                  15      
His Leu Ser Phe Arg Ser Phe Val Glu Ala Leu Arg Gln Asp Asn Asp 
            20                  25                  30          
Leu Val Asp Ile Asn Glu Pro Val Asp Pro Asp Leu Glu Ala Ala Ala 
        35                  40                  45              
Ile Thr Arg Leu Val Cys Glu Thr Asp Asp Lys Ala Pro Leu Phe Asn 
    50                  55                  60                  
Asn Val Ile Gly Ala Lys Asp Gly Leu Trp Arg Ile Leu Gly Ala Pro 
65                  70                  75                  80  
Ala Ser Leu Arg Ser Ser Pro Lys Glu Arg Phe Gly Arg Leu Ala Arg 
                85                  90                  95      
His Leu Ala Leu Pro Pro Thr Ala Ser Ala Lys Asp Ile Leu Asp Lys 
            100                 105                 110         
Met Leu Ser Ala Asn Ser Ile Pro Pro Ile Glu Pro Val Ile Val Pro 
        115                 120                 125             
Thr Gly Pro Val Lys Glu Asn Ser Ile Glu Gly Glu Asn Ile Asp Leu 
    130                 135                 140                 
Glu Ala Leu Pro Ala Pro Met Val His Gln Ser Asp Gly Gly Lys Tyr 
145                 150                 155                 160 
Ile Gln Thr Tyr Gly Met His Val Ile Gln Ser Pro Asp Gly Cys Trp 
                165                 170                 175     
Thr Asn Trp Ser Ile Ala Arg Ala Met Val Ser Gly Lys Arg Thr Leu 
            180                 185                 190         
Ala Gly Leu Val Ile Ser Pro Gln His Ile Arg Lys Ile Gln Asp Gln 
        195                 200                 205             
Trp Arg Ala Ile Gly Gln Glu Glu Ile Pro Trp Ala Leu Ala Phe Gly 
    210                 215                 220                 
Val Pro Pro Thr Ala Ile Met Ala Ser Ser Met Pro Ile Pro Asp Gly 
225                 230                 235                 240 
Val Ser Glu Ala Gly Tyr Val Gly Ala Ile Ala Gly Glu Pro Ile Lys 
                245                 250                 255     
Leu Val Lys Cys Asp Thr Asn Asn Leu Tyr Val Pro Ala Asn Ser Glu 
            260                 265                 270         
Ile Val Leu Glu Gly Thr Leu Ser Thr Thr Lys Met Ala Pro Glu Gly 
        275                 280                 285             
Pro Phe Gly Glu Met His Gly Tyr Val Tyr Pro Gly Glu Ser His Pro 
    290                 295                 300                 
Gly Pro Val Tyr Thr Val Asn Lys Ile Thr Tyr Arg Asn Asn Ala Ile 
305                 310                 315                 320 
Leu Pro Met Ser Ala Cys Gly Arg Leu Thr Asp Glu Thr Gln Thr Met 
                325                 330                 335     
Ile Gly Thr Leu Ala Ala Ala Glu Ile Arg Gln Leu Cys Gln Asp Ala 
            340                 345                 350         
Gly Leu Pro Ile Thr Asp Ala Phe Ala Pro Phe Val Gly Gln Ala Thr 
        355                 360                 365             
Trp Val Ala Leu Lys Val Asp Thr Lys Arg Leu Arg Ala Met Lys Thr 
    370                 375                 380                 
Asn Gly Lys Ala Phe Ala Lys Arg Val Gly Asp Val Val Phe Thr Gln 
385                 390                 395                 400 
Lys Pro Gly Phe Thr Ile His Arg Leu Ile Leu Val Gly Asp Asp Ile 
                405                 410                 415     
Asp Val Tyr Asp Asp Lys Asp Val Met Trp Ala Phe Thr Thr Arg Cys 
            420                 425                 430         
Arg Pro Gly Thr Asp Glu Val Phe Phe Asp Asp Val Val Gly Phe Gln 
        435                 440                 445             
Leu Ile Pro Tyr Met Ser His Gly Asn Ala Glu Ala Ile Lys Gly Gly 
    450                 455                 460                 
Lys Val Val Ser Asp Ala Leu Leu Thr Ala Glu Tyr Thr Thr Gly Lys 
465                 470                 475                 480 
Asp Trp Glu Ser Ala Asp Phe Lys Asn Ser Tyr Pro Lys Ser Ile Gln 
                485                 490                 495     
Asp Lys Val Leu Asn Ser Trp Glu Arg Leu Gly Phe Lys Lys Leu Asp 
            500                 505                 510         



<210> 2
<211> 189
<212> PRT
<213> Escherichia coli K-12

<400> 2
Met Lys Arg Leu Ile Val Gly Ile Ser Gly Ala Ser Gly Ala Ile Tyr 
1               5                   10                  15      
Gly Val Arg Leu Leu Gln Val Leu Arg Asp Val Thr Asp Ile Glu Thr 
            20                  25                  30          
His Leu Val Met Ser Gln Ala Ala Arg Gln Thr Leu Ser Leu Glu Thr 
        35                  40                  45              
Asp Phe Ser Leu Arg Glu Val Gln Ala Leu Ala Asp Val Thr His Asp 
    50                  55                  60                  
Ala Arg Asp Ile Ala Ala Ser Ile Ser Ser Gly Ser Phe Gln Thr Leu 
65                  70                  75                  80  
Gly Met Val Ile Leu Pro Cys Ser Ile Lys Thr Leu Ser Gly Ile Val 
                85                  90                  95      
His Ser Tyr Thr Asp Gly Leu Leu Thr Arg Ala Ala Asp Val Val Leu 
            100                 105                 110         
Lys Glu Arg Arg Pro Leu Val Leu Cys Val Arg Glu Thr Pro Leu His 
        115                 120                 125             
Leu Gly His Leu Arg Leu Met Thr Gln Ala Ala Glu Ile Gly Ala Val 
    130                 135                 140                 
Ile Met Pro Pro Val Pro Ala Phe Tyr His Arg Pro Gln Ser Leu Asp 
145                 150                 155                 160 
Asp Val Ile Asn Gln Thr Val Asn Arg Val Leu Asp Gln Phe Ala Ile 
                165                 170                 175     
Thr Leu Pro Glu Asp Leu Phe Ala Arg Trp Gln Gly Ala 
            180                 185                 

<210> 3
<211> 229
<212> PRT
<213> Candida albicans

<220> 
<223> Candida albicans (strain SC5314 / ATCC MYA-2876)

<400> 3
Met Ile Ala Arg Val Cys Leu Arg Arg Ser Asn Val Leu Pro Ile Phe 
1               5                   10                  15      
Gln Ile Pro Ser Arg Lys Tyr Ser Ile Asn Tyr Glu Lys Val Asn Asn 
            20                  25                  30          
Ser Ile Tyr Asn Asn Val Ile Lys Pro Lys Arg Ile Val Leu Ala Ile 
        35                  40                  45              
Thr Gly Ala Thr Gly Thr Gln Ile Gly Val Arg Leu Leu Glu Ile Leu 
    50                  55                  60                  
Lys Glu Leu Gly Val Glu Thr His Leu Val Met Ser Lys Trp Gly Ile 
65                  70                  75                  80  
Ala Thr Leu Lys Tyr Glu Thr Asp Tyr Gln Val Asp Tyr Val Thr Ser 
                85                  90                  95      
Leu Ala Thr Lys Thr Tyr Ser Ala Arg Asp Val Thr Ala Pro Ile Ser 
            100                 105                 110         
Ser Gly Ser Phe Val His Asp Gly Met Ile Val Ala Pro Cys Ser Met 
        115                 120                 125             
Lys Ser Leu Ser Ala Ile Arg Thr Gly Phe Thr Glu Asp Leu Ile Val 
    130                 135                 140                 
Arg Ala Ala Asp Val Ser Leu Lys Glu Arg Arg Lys Leu Leu Leu Val 
145                 150                 155                 160 
Ala Arg Glu Thr Pro Leu Ser Asp Ile His Leu Asp Asn Met Leu Tyr 
                165                 170                 175     
Leu Ser Arg Met Gly Val Thr Ile Phe Pro Pro Val Pro Ala Phe Tyr 
            180                 185                 190         
Thr Lys Pro Lys Thr Ile Asp Asp Ile Val Glu Gln Thr Cys Gly Arg 
        195                 200                 205             
Ile Leu Asp Asn Phe Gly Ile Asn Ile Asp Thr Phe Glu Arg Trp Asp 
    210                 215                 220                 
Gly Ile Asn His Arg 
225                 

<210> 4
<211> 227
<212> PRT
<213> Aspergillus niger

<400> 4
Met Phe Asn Ser Leu Leu Ser Gly Thr Thr Thr Pro Asn Ser Gly Arg 
1               5                   10                  15      
Ala Ser Pro Pro Ala Ser Glu Met Pro Ile Asp Asn Asp His Val Ala 
            20                  25                  30          
Val Ala Arg Pro Ala Pro Arg Arg Arg Arg Ile Val Val Ala Met Thr 
        35                  40                  45              
Gly Ala Thr Gly Ala Met Leu Gly Ile Lys Val Leu Ile Ala Leu Arg 
    50                  55                  60                  
Arg Leu Asn Val Glu Thr His Leu Val Met Ser Lys Trp Ala Glu Ala 
65                  70                  75                  80  
Thr Ile Lys Tyr Glu Thr Asp Tyr His Pro Ser Asn Val Arg Ala Leu 
                85                  90                  95      
Ala Asp Tyr Val His Asn Ile Asn Asp Met Ala Ala Pro Val Ser Ser 
            100                 105                 110         
Gly Ser Phe Arg Ala Asp Gly Met Ile Val Val Pro Cys Ser Met Lys 
        115                 120                 125             
Thr Leu Ala Ala Ile His Ser Gly Phe Cys Asp Asp Leu Ile Ser Arg 
    130                 135                 140                 
Thr Ala Asp Val Met Leu Lys Glu Arg Arg Arg Leu Val Leu Val Ala 
145                 150                 155                 160 
Arg Glu Thr Pro Leu Ser Glu Ile His Leu Arg Asn Met Leu Glu Val 
                165                 170                 175     
Thr Arg Ala Gly Ala Val Ile Phe Pro Pro Val Pro Ala Phe Tyr Ile 
            180                 185                 190         
Lys Ala Gly Ser Ile Glu Asp Leu Ile Asp Gln Ser Val Gly Arg Met 
        195                 200                 205             
Leu Asp Leu Phe Asp Leu Asp Thr Gly Asp Phe Glu Arg Trp Asn Gly 
    210                 215                 220                 
Trp Glu Lys 
225         

<210> 5
<211> 242
<212> PRT
<213> Saccharomyces cerevisiae S288c

<400> 5
Met Leu Leu Phe Pro Arg Arg Thr Asn Ile Ala Phe Phe Lys Thr Thr 
1               5                   10                  15      
Gly Ile Phe Ala Asn Phe Pro Leu Leu Gly Arg Thr Ile Thr Thr Ser 
            20                  25                  30          
Pro Ser Phe Leu Thr His Lys Leu Ser Lys Glu Val Thr Arg Ala Ser 
        35                  40                  45              
Thr Ser Pro Pro Arg Pro Lys Arg Ile Val Val Ala Ile Thr Gly Ala 
    50                  55                  60                  
Thr Gly Val Ala Leu Gly Ile Arg Leu Leu Gln Val Leu Lys Glu Leu 
65                  70                  75                  80  
Ser Val Glu Thr His Leu Val Ile Ser Lys Trp Gly Ala Ala Thr Met 
                85                  90                  95      
Lys Tyr Glu Thr Asp Trp Glu Pro His Asp Val Ala Ala Leu Ala Thr 
            100                 105                 110         
Lys Thr Tyr Ser Val Arg Asp Val Ser Ala Cys Ile Ser Ser Gly Ser 
        115                 120                 125             
Phe Gln His Asp Gly Met Ile Val Val Pro Cys Ser Met Lys Ser Leu 
    130                 135                 140                 
Ala Ala Ile Arg Ile Gly Phe Thr Glu Asp Leu Ile Thr Arg Ala Ala 
145                 150                 155                 160 
Asp Val Ser Ile Lys Glu Asn Arg Lys Leu Leu Leu Val Thr Arg Glu 
                165                 170                 175     
Thr Pro Leu Ser Ser Ile His Leu Glu Asn Met Leu Ser Leu Cys Arg 
            180                 185                 190         
Ala Gly Val Ile Ile Phe Pro Pro Val Pro Ala Phe Tyr Thr Arg Pro 
        195                 200                 205             
Lys Ser Leu His Asp Leu Leu Glu Gln Ser Val Gly Arg Ile Leu Asp 
    210                 215                 220                 
Cys Phe Gly Ile His Ala Asp Thr Phe Pro Arg Trp Glu Gly Ile Lys 
225                 230                 235                 240 
Ser Lys 
        

<210> 6
<211> 180
<212> PRT
<213> Cryptococcus gattii WM276

<220> 
<223> serotype B

<400> 6
Met Arg Arg Lys Arg Tyr Val Val Ala Val Thr Gly Ala Thr Gly Ala 
1               5                   10                  15      
Thr Leu Ala Ile Arg Leu Leu Gln Ala Leu Arg Ala Leu Asp Ile Glu 
            20                  25                  30          
Thr His Leu Ile Ile Ser Lys Trp Ala Val Lys Thr Leu Lys Tyr Glu 
        35                  40                  45              
Thr Asp Met Ile Glu Arg Glu Leu Lys Asp Leu Ala Asp Tyr Ser Tyr 
    50                  55                  60                  
Ser Asn Ser Asp Leu Ala Ala Pro Pro Ser Ser Gly Ser Phe Ile His 
65                  70                  75                  80  
Asp Gly Met Phe Ile Ile Pro Cys Ser Met Lys Thr Leu Ala Ala Val 
                85                  90                  95      
Arg Ile Gly Leu Gly Asp Glu Leu Ile Ser Arg Ser Ala Asp Val Cys 
            100                 105                 110         
Leu Lys Glu Gly Arg Lys Leu Met Leu Val Val Arg Glu Thr Pro Leu 
        115                 120                 125             
Asn Asp Ile His Leu Glu Asn Met Leu Phe Leu Arg Arg Ala Gly Ala 
    130                 135                 140                 
Ile Ile Phe Pro Pro Val Pro Ala Tyr Tyr Ile Arg Pro Gln Thr Ile 
145                 150                 155                 160 
Asp Asp Leu Thr Asn Gln Thr Val Gly Arg Ile Leu Asp Ser Ser Lys 
                165                 170                 175     
Cys Ser Gln Lys 
            180 

<210> 7
<211> 192
<212> PRT
<213> Bacillus subtilis

<400> 7
Met Lys Leu Val Ile Gly Met Thr Gly Ala Thr Gly Ala Ile Phe Gly 
1               5                   10                  15      
Ile Arg Leu Leu Glu Tyr Leu Lys Ala Ala Glu Ile Glu Thr His Leu 
            20                  25                  30          
Val Val Ser Pro Trp Ala Asn Val Thr Ile Thr His Glu Thr Asp Tyr 
        35                  40                  45              
Thr Leu Lys Asp Val Glu Lys Leu Ala Ser Tyr Thr Tyr Ser His Lys 
    50                  55                  60                  
Asp Gln Ala Ala Ala Ile Ser Ser Gly Ser Phe Glu Thr Asp Gly Met 
65                  70                  75                  80  
Ile Ile Ala Pro Cys Ser Met Lys Ser Leu Ala Ser Ile Arg Thr Gly 
                85                  90                  95      
Met Ala Asp Asn Leu Leu Thr Arg Ala Ala Asp Val Ile Leu Lys Glu 
            100                 105                 110         
Arg Lys Lys Leu Val Leu Leu Thr Arg Glu Thr Pro Leu Ser Gln Ile 
        115                 120                 125             
His Leu Glu Asn Met Leu Ala Leu Thr Lys Met Gly Ser Val Ile Leu 
    130                 135                 140                 
Pro Pro Met Pro Ala Phe Tyr Asn Lys Pro Ala Asp Met Asp Glu Leu 
145                 150                 155                 160 
Ile Asp His Ile Val Phe Arg Thr Leu Asp Gln Phe Gly Ile Arg Leu 
                165                 170                 175     
Pro Glu Ala Lys Arg Trp Tyr Gly Ile Glu Lys Gln Lys Gly Gly Ile 
            180                 185                 190         



<210> 8
<211> 209
<212> PRT
<213> Pseudomonas aeruginosa

<400> 8
Met Ser Gly Pro Glu Arg Ile Thr Leu Ala Met Thr Gly Ala Ser Gly 
1               5                   10                  15      
Ala Gln Tyr Gly Leu Arg Leu Leu Asp Cys Leu Val Gln Glu Glu Arg 
            20                  25                  30          
Glu Val His Phe Leu Ile Ser Lys Ala Ala Gln Leu Val Met Ala Thr 
        35                  40                  45              
Glu Thr Asp Val Ala Leu Pro Ala Lys Pro Gln Ala Met Gln Ala Phe 
    50                  55                  60                  
Leu Thr Glu Tyr Cys Gly Ala Ala Ala Gly Gln Ile Arg Val Phe Gly 
65                  70                  75                  80  
Gln Asn Asp Trp Met Ala Pro Pro Ala Ser Gly Ser Ser Ala Pro Asn 
                85                  90                  95      
Ala Met Val Ile Cys Pro Cys Ser Thr Gly Thr Leu Ser Ala Val Ala 
            100                 105                 110         
Thr Gly Ala Cys Asn Asn Leu Ile Glu Arg Ala Ala Asp Val Ala Leu 
        115                 120                 125             
Lys Glu Arg Arg Pro Leu Val Leu Val Pro Arg Glu Ala Pro Phe Ser 
    130                 135                 140                 
Ser Ile His Leu Glu Asn Met Leu Lys Leu Ser Asn Leu Gly Ala Val 
145                 150                 155                 160 
Ile Leu Pro Ala Ala Pro Gly Phe Tyr His Gln Pro Gln Ser Val Glu 
                165                 170                 175     
Asp Leu Val Asp Phe Val Val Ala Arg Ile Leu Asn Thr Leu Gly Ile 
            180                 185                 190         
Pro Gln Asp Met Leu Pro Arg Trp Gly Glu Gln His Leu Val Ser Asp 
        195                 200                 205             
Glu 
    

<210> 9
<211> 219
<212> PRT
<213> Enterobacter sp.

<220> 
<223> Enterobacter sp. DC4

<400> 9
Met Leu Arg Gln Val Arg Ala Asn Ala Leu Thr Cys Asn Ser Pro Gln 
1               5                   10                  15      
Asn Pro Ala Gln Ser Ala Leu Lys Ser Val Arg Ala Lys Ile Met Lys 
            20                  25                  30          
Arg Leu Ile Val Gly Leu Ser Gly Ala Ser Gly Ala Ile Tyr Gly Val 
        35                  40                  45              
Arg Leu Leu Gln Val Leu Arg Asn Val Ala Glu Val Glu Thr His Leu 
    50                  55                  60                  
Val Met Ser Gln Ala Ala Arg Gln Thr Leu Ser Leu Glu Thr Asp Leu 
65                  70                  75                  80  
Ser Leu Arg Asp Val Gln Ala Leu Ala Asp Val Val His Asp Ala Arg 
                85                  90                  95      
Asp Ile Ala Ala Ser Ile Ser Ser Gly Ser Phe Lys Thr Ala Gly Met 
            100                 105                 110         
Val Ile Leu Pro Cys Ser Ile Lys Thr Leu Ser Gly Ile Val Asn Ser 
        115                 120                 125             
Tyr Thr Asp Thr Leu Val Thr Arg Ala Ala Asp Val Val Leu Lys Glu 
    130                 135                 140                 
Arg Arg Pro Leu Val Leu Cys Val Arg Glu Thr Pro Leu His Leu Gly 
145                 150                 155                 160 
His Leu Arg Leu Met Thr Gln Ala Ala Glu Leu Gly Ala Ile Ile Met 
                165                 170                 175     
Pro Pro Val Pro Ala Phe Tyr His Arg Pro Thr Ser Leu Asp Asp Val 
            180                 185                 190         
Ile Asn Gln Thr Val Asn Arg Val Leu Asp Gln Phe Asp Ile Asp Leu 
        195                 200                 205             
Pro Glu Asp Leu Phe Thr Arg Trp Gln Gly Ala 
    210                 215                 

<210> 10
<211> 503
<212> PRT
<213> Cladophialophora psammophila CBS 110553

<400> 10
Met Val Ser Ser Thr Phe Thr Gln Pro Pro Asp Gly Pro Ala His Leu 
1               5                   10                  15      
Ser Phe Arg Ser Phe Val Ser Ala Leu Lys Glu Asp Gly Asp Leu Val 
            20                  25                  30          
Glu Ile Asn Asp Glu Ile Asp Pro Tyr Leu Glu Ala Ala Ala Ile Ile 
        35                  40                  45              
Arg Lys Val Cys Glu Thr Asp Gly Lys Ala Pro Leu Phe Asn Asn Leu 
    50                  55                  60                  
Lys Gly Asn Val Asn Gly Phe Trp Arg Ile Leu Gly Ala Pro Ala Ser 
65                  70                  75                  80  
Leu Arg Arg Asp Pro Ser Arg Arg Tyr Ala Arg Leu Ala Arg His Leu 
                85                  90                  95      
Ala Leu Pro Pro Thr Ala Gly Met Lys Asp Ile Leu Asp Lys Met Leu 
            100                 105                 110         
Ser Ala Lys Ser Ser Ala Pro Ile Pro Pro Lys Val Val Ser Thr Gly 
        115                 120                 125             
Pro Cys Lys Ala His Ile Leu Asp Glu Phe Asp Leu Glu Lys Leu Pro 
    130                 135                 140                 
Ala Pro Phe Leu His Gln Ser Asp Gly Gly Lys Tyr Ile Gln Thr Tyr 
145                 150                 155                 160 
Gly Met His Val Ile Gln Ser Pro Asp Gly Thr Trp Thr Asn Trp Ser 
                165                 170                 175     
Ile Ala Arg Ala Met Val Lys Asp Lys Asn His Leu Val Gly Leu Val 
            180                 185                 190         
Ile Glu Pro Gln His Ile Trp Gln Ile Arg Glu Gln Trp Lys Ala Ile 
        195                 200                 205             
Gly Lys Asp Val Pro Trp Ala Leu Cys Phe Gly Val Pro Pro Ala Ala 
    210                 215                 220                 
Ile Met Ala Ala Ser Met Pro Leu Pro Ser Gly Leu Ser Glu Ala Asp 
225                 230                 235                 240 
Tyr Ile Gly Ala Met Thr Gly Thr Ala Leu Asp Val Val Lys Cys Glu 
                245                 250                 255     
Thr Asn Asp Leu Tyr Val Pro Ala Thr Ser Glu Ile Val Phe Glu Gly 
            260                 265                 270         
Thr Leu Ser Val Ser Glu Leu Ala Pro Glu Gly Pro Phe Gly Glu Met 
        275                 280                 285             
His Gly Tyr Val Phe Pro Gly Asp Ser His Leu Gln Pro Val Tyr Thr 
    290                 295                 300                 
Val Asn Lys Ile Thr His Arg Thr Asp Ala Ile Leu Pro Val Ser Asn 
305                 310                 315                 320 
Cys Gly Arg Ile Thr Asp Glu Thr Gln Thr Met Ile Gly Pro Leu Ala 
                325                 330                 335     
Ala Ala Glu Ile Arg Gln Leu Cys Gln Asp His Gly Leu Pro Ile Lys 
            340                 345                 350         
Glu Ala Met Gly Leu Phe Glu Thr Gln Val Thr Trp Val Ala Leu Gln 
        355                 360                 365             
Val Asp Thr Lys Lys Leu Ala Asp Met Asn Leu Thr Pro Glu Ala Phe 
    370                 375                 380                 
Arg Lys Leu Val Gly Asp Leu Val Tyr Gly His Lys Ala Gly Tyr Thr 
385                 390                 395                 400 
Ile His Arg Leu Val Leu Val Gly Glu Asp Ile Asp Val Tyr Asp Phe 
                405                 410                 415     
Lys Asp Val Leu Phe Ala Phe Ser Thr Arg Cys Arg Pro Gln Thr Asp 
            420                 425                 430         
Glu Leu Phe Tyr Gln Asp Cys Arg Gly Phe Ala Leu Ile Pro Tyr Met 
        435                 440                 445             
Gly His Gly Thr Ala Ala Pro His Lys Gly Gly Lys Val Val Ser Asp 
    450                 455                 460                 
Ala Leu Leu Pro Ala Glu Tyr Thr Gly Gly Gln Asp Trp Glu Leu Ala 
465                 470                 475                 480 
Asp Phe Lys His Ser Tyr Pro Glu Asn Leu Gln Lys Ser Val Asp Glu 
                485                 490                 495     
Arg Trp Ser Ala Trp Gly Phe 
            500             

<210> 11
<211> 505
<212> PRT
<213> Cladophialophora immunda

<400> 11
Met Val Ser Asn Thr Phe Thr Gln Ser Ser Glu Gly Pro Ala His Leu 
1               5                   10                  15      
Ser Phe Arg Ser Phe Val Ala Ala Leu Lys Glu Asp Gly Asp Val Val 
            20                  25                  30          
Glu Ile Asn Asp Glu Val Asp Pro His Leu Glu Ala Ala Ala Ile Ile 
        35                  40                  45              
Arg Lys Ala Cys Glu Thr Asp Asp Lys Ala Pro Leu Leu Asn Asn Leu 
    50                  55                  60                  
Lys Gly Asn Val Asn Gly Phe Trp Arg Ile Leu Gly Ala Pro Ala Ser 
65                  70                  75                  80  
Leu Arg Arg Asp Pro Ser Glu Arg Tyr Ala Arg Leu Ala Arg His Leu 
                85                  90                  95      
Ala Leu Pro Pro Thr Ala Gly Met Lys Asp Ile Leu Asp Lys Met Leu 
            100                 105                 110         
Ser Ala Lys Thr Ser Ala Pro Val Pro Pro Arg Val Val Ser Thr Gly 
        115                 120                 125             
Pro Cys Lys Glu His Ile Leu Asp Gln Phe Asp Leu Glu Lys Leu Pro 
    130                 135                 140                 
Ser Pro Phe Leu His Gln Ser Asp Gly Gly Lys Tyr Ile Gln Thr Tyr 
145                 150                 155                 160 
Gly Met His Val Val Gln Ser Pro Asp Gly Lys Trp Thr Asn Trp Ser 
                165                 170                 175     
Ile Ala Arg Ala Met Val Lys Asp Lys Asn His Leu Val Gly Leu Val 
            180                 185                 190         
Ile Glu Pro Gln His Ile Trp Gln Ile Arg Gln Gln Trp Lys Ala Ile 
        195                 200                 205             
Gly Lys Asp Val Pro Trp Ala Leu Cys Phe Gly Val Pro Pro Ala Ala 
    210                 215                 220                 
Ile Met Ala Ala Ser Met Pro Leu Pro Glu Gly Val Thr Glu Ala Asp 
225                 230                 235                 240 
Tyr Ile Gly Ala Met Thr Gly Asn Pro Leu Asp Val Val Lys Cys Glu 
                245                 250                 255     
Thr Asn Asp Met Tyr Val Pro Ala Asn Ser Glu Ile Val Phe Glu Gly 
            260                 265                 270         
Thr Leu Ser Val Ser Glu Leu Ala Pro Glu Gly Pro Phe Gly Glu Met 
        275                 280                 285             
His Gly Tyr Val Phe Pro Gly Asp Ser His Pro Gln Pro Val Tyr Thr 
    290                 295                 300                 
Val Asn Lys Ile Thr His Arg Thr Asp Ala Ile Leu Pro Val Ser Asn 
305                 310                 315                 320 
Cys Gly Arg Ile Thr Asp Glu Thr Gln Thr Met Ile Gly Pro Leu Ala 
                325                 330                 335     
Ala Ala Glu Ile Arg Gln Leu Cys Gln Asp His Ser Leu Pro Val Lys 
            340                 345                 350         
Glu Ala Met Ala Leu Phe Glu Thr Gln Val Thr Trp Val Ala Leu Gln 
        355                 360                 365             
Ile Asp Thr Lys Lys Leu Arg Asp Met Lys Leu Ala Pro Glu Ala Phe 
    370                 375                 380                 
Arg Lys Leu Val Gly Asp Leu Val Phe Gly His Lys Ala Gly Tyr Thr 
385                 390                 395                 400 
Ile His Arg Leu Val Leu Val Gly Glu Asp Ile Asp Val Tyr Asp Phe 
                405                 410                 415     
Lys Asp Val Leu Phe Ala Phe Ser Thr Arg Cys Arg Pro Gln Thr Asp 
            420                 425                 430         
Glu Leu Phe Tyr Gln Asp Cys Arg Gly Phe Ala Leu Ile Pro Tyr Met 
        435                 440                 445             
Gly His Gly Thr Ala Glu Pro Asn Lys Gly Gly Lys Val Val Ser Asp 
    450                 455                 460                 
Ala Leu Leu Pro Ala Glu Tyr Ala Gly Gly Gln Asn Trp Glu Leu Ala 
465                 470                 475                 480 
Asp Phe Lys His Ser Tyr Pro Glu His Leu Gln Lys Ser Val Asn Glu 
                485                 490                 495     
Arg Trp Met Ala Trp Gly Phe Gly Lys 
            500                 505 

<210> 12
<211> 508
<212> PRT
<213> Sphaerulina musiva SO2202

<400> 12
Met Ser Ser Ser Lys Gln Gln His Leu Ser His Ala Asn Gln Glu Leu 
1               5                   10                  15      
Pro His Leu Asn Phe Arg Ser Phe Val Gln Ala Leu Lys Asp Asp Gly 
            20                  25                  30          
Asp Leu Ile Glu Ile Asp Asp Glu Ile Asp Pro His Leu Glu Ala Gly 
        35                  40                  45              
Ala Ile Ile Arg Arg Ala Cys Glu Thr Asp Gly Lys Ala Pro Leu Leu 
    50                  55                  60                  
Asn Asn Leu Lys Gly Ala Lys Asp Gly Leu Trp Arg Ile Leu Gly Ala 
65                  70                  75                  80  
Pro Ala Ser Leu Arg Ser Asp Pro Ser Gln Lys Tyr Gly Arg Val Ala 
                85                  90                  95      
Arg His Leu Ala Leu Pro Pro Thr Ala Thr Met Lys Asp Ile Leu Asp 
            100                 105                 110         
Lys Met Leu Ser Ala Ala His Ala Glu Pro Ile Pro Pro Asn Ile Val 
        115                 120                 125             
Glu Ser Gly Pro Val Lys Glu Asn Lys Leu Val Asp Gly Glu Phe Asp 
    130                 135                 140                 
Leu Ser Thr Leu Pro Ala Pro Trp Leu His Gln Ala Asp Gly Gly Lys 
145                 150                 155                 160 
Tyr Ile Gln Thr Tyr Gly Met His Ile Val Gln Ser Pro Asp Gly Lys 
                165                 170                 175     
Trp Thr Asn Trp Ser Ile Ala Arg Ala Met Val His Asp Lys Asn His 
            180                 185                 190         
Leu Thr Gly Leu Val Ile Glu Pro Gln His Ile Trp Gln Ile His Gln 
        195                 200                 205             
Gln Trp Lys Lys Val Gly Lys Asp Val Pro Trp Ala Leu Ala Phe Gly 
    210                 215                 220                 
Val Pro Pro Ala Ala Ile Met Ala Ala Ser Met Pro Ile Pro Asp Gly 
225                 230                 235                 240 
Val Thr Glu Ala Gly Tyr Ile Gly Ala Met Thr Gly Ser Ala Leu Asp 
                245                 250                 255     
Val Val Lys Cys Glu Thr Asn Gly Met Tyr Val Pro Ala Asn Ala Glu 
            260                 265                 270         
Ile Val Leu Glu Gly Thr Leu Ser Ile Thr Glu Thr Ala Pro Glu Gly 
        275                 280                 285             
Pro Phe Gly Glu Met His Gly Tyr Val Phe Pro Gly Asp Thr His Pro 
    290                 295                 300                 
Trp Pro Lys Tyr Lys Val Asp Ala Ile Thr Tyr Arg Asn Gly Ala Ile 
305                 310                 315                 320 
Leu Pro Val Ser Asn Cys Gly Arg Ile Thr Asp Glu Thr His Thr Leu 
                325                 330                 335     
Ile Gly Pro Leu Ala Ala Ala Gln Ile Arg Gln Leu Cys Gln Asp Ala 
            340                 345                 350         
Gly Leu Pro Ile Thr Asp Ala Phe Ala Pro Phe His Thr Gln Val Thr 
        355                 360                 365             
Trp Val Ala Leu Lys Val Asp Ile Glu Lys Leu Gly Lys Met Asn Thr 
    370                 375                 380                 
Thr Pro Glu Ala Phe Arg Lys Gln Val Gly Asp Leu Val Phe Asn His 
385                 390                 395                 400 
Lys Ala Gly Tyr Thr Ile His Arg Leu Val Leu Cys Gly Ser Asp Ile 
                405                 410                 415     
Asp Val Tyr Glu Trp Asp Asp Ile Ala Phe Ala Phe Ser Thr Arg Cys 
            420                 425                 430         
Arg Pro Asn Lys Asp Glu Thr Phe Tyr Glu Asp Cys Gln Gly Phe Pro 
        435                 440                 445             
Leu Ile Pro Tyr Met Ser His Gly Thr Gly Ser Pro Ile Lys Gly Gly 
    450                 455                 460                 
Lys Val Ile Ser Asp Ala Leu Met Pro Ser Glu Tyr Arg Gly Gln Gln 
465                 470                 475                 480 
Asp Trp Gln Gln Ala Ser Phe Lys His Ser Tyr Pro Glu Ser Leu Gln 
                485                 490                 495     
Lys Ser Val Ile Glu Arg Trp Ala Ser Trp Gly Phe 
            500                 505             

<210> 13
<211> 503
<212> PRT
<213> Cladophialophora bantiana CBS 173.52

<400> 13
Met Ala Ser Arg Thr Phe Thr Gln Pro Ser Asp Gly Pro Ala His Leu 
1               5                   10                  15      
Ser Phe Arg Ser Phe Val Ser Ala Leu Lys Glu Asp Gly Asp Leu Val 
            20                  25                  30          
Glu Ile Asn Asp Glu Ile Asp Pro Tyr Leu Glu Ala Ala Ala Ile Ile 
        35                  40                  45              
Arg Lys Ala Cys Glu Thr Asp Gly Lys Ala Pro Leu Phe Asn Asn Leu 
    50                  55                  60                  
Lys Gly Asn Val Asn Gly Phe Trp Arg Ile Leu Gly Ala Pro Ala Ser 
65                  70                  75                  80  
Leu Arg Arg Asp Pro Ser Arg Arg Tyr Ala Arg Leu Ala Arg His Leu 
                85                  90                  95      
Ala Leu Pro Pro Thr Ala Gly Met Lys Asp Ile Leu Asp Lys Val Leu 
            100                 105                 110         
Ser Ala Lys Thr Ser Ala Pro Ile Pro Pro Lys Val Val Ser Thr Gly 
        115                 120                 125             
Pro Cys Lys Ala His Ile Leu Asp Glu Phe Asp Leu Glu Lys Leu Pro 
    130                 135                 140                 
Ala Pro Phe Leu His Gln Cys Asp Gly Gly Lys Tyr Ile Gln Thr Tyr 
145                 150                 155                 160 
Gly Met His Val Val Gln Ser Pro Asp Gly Thr Trp Thr Asn Trp Ser 
                165                 170                 175     
Ile Ala Arg Ala Met Val Lys Asp Lys Asn His Leu Val Gly Leu Val 
            180                 185                 190         
Ile Glu Pro Gln His Ile Trp Gln Ile Arg Glu Gln Trp Lys Ala Ile 
        195                 200                 205             
Gly Lys Asp Val Pro Trp Ala Leu Cys Phe Gly Val Pro Pro Ala Ala 
    210                 215                 220                 
Ile Met Ala Ala Ser Met Pro Leu Pro Asp Gly Ile Ser Glu Ala Asp 
225                 230                 235                 240 
Tyr Ile Gly Ala Met Thr Gly Thr Ala Leu Asp Val Val Lys Cys Glu 
                245                 250                 255     
Thr Asn Asp Leu Tyr Val Pro Ala Thr Ser Glu Ile Val Phe Glu Gly 
            260                 265                 270         
Thr Leu Ser Val Ser Glu Leu Ala Pro Glu Gly Pro Phe Gly Glu Met 
        275                 280                 285             
His Gly Tyr Val Phe Pro Gly Asp Ser His Leu Gln Pro Val Tyr Thr 
    290                 295                 300                 
Val Asn Lys Ile Thr His Arg Thr Asp Ala Ile Leu Pro Val Ser Asn 
305                 310                 315                 320 
Cys Gly Arg Ile Thr Asp Glu Thr Gln Thr Met Ile Gly Pro Leu Ala 
                325                 330                 335     
Ala Ala Glu Ile Arg Gln Leu Cys Gln Asp His Gly Leu Pro Ile Lys 
            340                 345                 350         
Glu Ala Met Gly Leu Phe Glu Thr Gln Val Thr Trp Val Ala Leu Gln 
        355                 360                 365             
Val Asp Thr Lys Lys Leu Ala Asp Met Asn Leu Ala Pro Glu Ala Phe 
    370                 375                 380                 
Arg Lys Val Val Gly Asp Leu Val Tyr Gly His Lys Ala Gly Tyr Thr 
385                 390                 395                 400 
Ile His Arg Leu Val Leu Val Gly Glu Asp Ile Asp Val Tyr Asp Phe 
                405                 410                 415     
Lys Asp Val Leu Phe Ala Phe Ser Thr Arg Cys Arg Pro Gln Thr Asp 
            420                 425                 430         
Glu Leu Phe Tyr Gln Asp Cys Arg Gly Phe Ala Leu Ile Pro Tyr Met 
        435                 440                 445             
Gly His Gly Thr Ala Ala Pro Asn Lys Gly Gly Lys Val Val Ser Asp 
    450                 455                 460                 
Ala Leu Leu Pro Ala Glu Tyr Thr Gly Gly Gln Asp Trp Glu Leu Ala 
465                 470                 475                 480 
Asp Phe Lys His Ser Tyr Pro Glu Asn Leu Gln Lys Ser Val Asp Glu 
                485                 490                 495     
Arg Trp Ser Ala Trp Gly Phe 
            500             

