                         SEQUENCE LISTING

<110>  MAB DISCOVERY GMBH
 
<120>  HER-2 binding antibodies

<130>  B198-0005WO1

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  1

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Asn 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Ser His Ser Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Ala 
                85                  90                  95      


Ala Gly Gly Ser Gly Ala Tyr Asn Leu Trp Gly Gln Gly Met Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  2

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Asn 
            20                  25                  30          


Met Ala Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Asn Ala Gly Gly Thr Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Ile Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ser 
65                  70                  75                  80  


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ser Tyr 
                85                  90                  95      


Thr Ser Asn Ser Gly Ala Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  3
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  3

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ser Gly Gly Asn Ala His Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Asp 
                85                  90                  95      


Asp Ser Ser Gly Leu Arg Leu Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  4
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  4

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr Gly 
            20                  25                  30          


Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Ser Gly Ser Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Lys Asp Thr Ala Thr Tyr Phe Cys Ala Arg Gly Val 
                85                  90                  95      


Val Pro Gly Tyr Asn Ala Gly Gly Leu Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  5
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  5

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr Ala 
            20                  25                  30          


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Ala Ile Ser Asp Asn Thr Trp Phe Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 
65                  70                  75                  80  


Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ala 
                85                  90                  95      


Leu Tyr Ala Gly Tyr Thr Ala Gly Tyr Tyr Phe Ser Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  6

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Ser Tyr 
            20                  25                  30          


Tyr Met Cys Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Cys Ile Tyr Gly Gly Ser Ser Ser Ser Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gln Ile Tyr Asp Asp Ser Gly Phe Asn Leu Trp Gly Pro 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  7
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  7

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Thr Ala 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Phe Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Ser 
65                  70                  75                  80  


Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ser Ala Tyr Gly Ser Arg 
                85                  90                  95      


Tyr Val Gly Gly Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  8

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Gly Asn Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Glu Ser Gly Val Ser Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Ser 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Ser Ala Tyr Gly Ser Val 
                85                  90                  95      


Tyr Val Gly Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  9
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  9

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Asn Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Met 
        35                  40                  45              


Ser Tyr Ala Ser Ser Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Glu Tyr Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Asp Val Gly Ser Asn 
                85                  90                  95      


Tyr Leu Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110 


<210>  10
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  10

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Gly Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Ser Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Cys Thr Ala Ala Gly Ser Val 
                85                  90                  95      


Ser Val Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Asn 
            100                 105                 110 


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  11

Asp Pro Val Leu Thr Gln Thr Pro Ser Ser Ala Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ser Ala Thr Tyr Tyr Cys Gln Asn Asn Asn Gly Gly Ser Tyr 
                85                  90                  95      


Ser Ser Ala Phe Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210>  12
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  12

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys Gln Ala Ser Gln Ser Ile Ser Ile Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Asp Leu Glu Cys 
65                  70                  75                  80  


Ala Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Asn Tyr Gly Ser Gly Ser 
                85                  90                  95      


Ser Ser Trp Glu Gly Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110         


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  13

Ser Tyr Asn Met Gly 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  14

Asn Tyr Asn Met Ala 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  15

Ser Tyr Ala Met Ser 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  16

Asn Tyr Gly Val Ser 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  17

Ser Tyr Ala Met Ser 
1               5   


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  18

Ser Ser Tyr Tyr Met Cys 
1               5       


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  19

Ile Ile Ser His Ser Asp Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  20

Ile Ile Asn Ala Gly Gly Thr Ala Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  21

Ile Ile Tyr Ser Gly Gly Asn Ala His Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  22

Ile Ile Ser Gly Ser Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  23

Ile Ile Tyr Ala Ile Ser Asp Asn Thr Trp Phe Ala Ser Trp Ala Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  24

Cys Ile Tyr Gly Gly Ser Ser Ser Ser Thr Tyr Tyr Ala Ser Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  25

Gly Ala Ala Gly Gly Ser Gly Ala Tyr Asn Leu 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  26

Ser Tyr Thr Ser Asn Ser Gly Ala Phe Asn Ile 
1               5                   10      


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  27

Gly Asp Asp Ser Ser Gly Leu Arg Leu 
1               5                   


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  28

Gly Val Val Pro Gly Tyr Asn Ala Gly Gly Leu 
1               5                   10      


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  29

Ala Leu Tyr Ala Gly Tyr Thr Ala Gly Tyr Tyr Phe Ser Leu 
1               5                   10                  


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  30

Asp Gln Ile Tyr Asp Asp Ser Gly Phe Asn Leu 
1               5                   10      


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  31

Gln Ala Ser Gln Ser Ile Ser Thr Ala Leu Gly 
1               5                   10      


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  32

Gln Ala Ser Gln Ser Ile Gly Asn Ala Leu Ala 
1               5                   10      


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  33

Gln Ala Ser Gln Ser Ile Ser Asn Leu Leu Ala 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  34

Gln Ala Ser Gln Gly Ile Ser Thr Ala Leu Ala 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  35

Gln Ala Ser Gln Ser Ile Tyr Ser Tyr Leu Ser 
1               5                   10      


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  36

Gln Ala Ser Gln Ser Ile Ser Ile Tyr Leu Ser 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  37

Gly Ala Ser Asn Leu Glu Phe 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  38

Gly Ala Ser Asn Leu Glu Ser 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  39

Tyr Ala Ser Ser Leu Ala Ser 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  40

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  41

Ser Ala Ser Thr Leu Ala Ser 
1               5           


<210>  42
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  42

Lys Ala Ser Thr Leu Glu Ser 
1               5           


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  43

Gln Cys Ser Ala Tyr Gly Ser Arg Tyr Val Gly Gly 
1               5                   10          


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  44

Gln Cys Ser Ala Tyr Gly Ser Val Tyr Val Gly Thr 
1               5                   10          


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  45

Gln Cys Thr Asp Val Gly Ser Asn Tyr Leu Gly Ala 
1               5                   10          


<210>  46
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  46

Gln Cys Thr Ala Ala Gly Ser Val Ser Val Gly Ala 
1               5                   10          


<210>  47
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  47

Gln Asn Asn Asn Gly Gly Ser Tyr Ser Ser Ala Phe Gly Ala 
1               5                   10                  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  48

Gln Ser Asn Tyr Gly Ser Gly Ser Ser Ser Trp Glu Gly Ala 
1               5                   10                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  49

Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  50
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  50

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  51

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  52
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  52

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  53

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  54

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  55

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  56

Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  57
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  57

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  58
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  58

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
1               5                   10                  


<210>  59
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  59

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  60
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  60

Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  


<210>  61
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  61

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  62
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  62

Arg Ile Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Ser 
1               5                   10                  15      


Ser Pro Thr Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  63
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  63

Arg Phe Thr Ile Ser Arg Thr Ser Thr Thr Val Asp Leu Lys Met Thr 
1               5                   10                  15      


Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  64
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  64

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Lys Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  65
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  65

Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile Thr 
1               5                   10                  15      


Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30  


<210>  66
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  66

Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr Leu Gln Met 
1               5                   10                  15      


Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
            20                  25                  30      


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  67

Trp Gly Gln Gly Met Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  68

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  69

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  70
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  70

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  71

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  72
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  72

Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  73
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  73

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Glu Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  74
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  74

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  75
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  75

Asp Val Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  76
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  76

Asp Ile Val Met Thr Gln Thr Pro Ala Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  77
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  77

Asp Pro Val Leu Thr Gln Thr Pro Ser Ser Ala Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  78
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  78

Asp Ile Val Met Thr Gln Thr Pro Ser Ser Val Ser Glu Pro Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Lys Cys 
            20              


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  79

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  80

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  81

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Met Ser 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  82

Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  83

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Glu Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  84

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  85
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  85

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Ser Gly Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  86
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  86

Gly Val Ser Ser Arg Phe Arg Gly Ser Arg Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Ser Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  87
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  87

Gly Val Ser Ser Arg Phe Lys Gly Ser Arg Ser Gly Thr Glu Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  88
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  88

Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  89
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  89

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ser Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  90
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  90

Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Glu Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Asp Leu Glu Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  91

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  92

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  93

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  94

Phe Gly Gly Gly Thr Glu Val Val Val Asn 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  95

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric antibody

<400>  96

Phe Gly Gly Gly Thr Glu Val Val Val Lys 
1               5                   10  


<210>  97
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  98
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  98

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  99
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  99

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
            100                 105                 110         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        115                 120                 125             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    130                 135                 140                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
145                 150                 155                 160 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                165                 170                 175     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            180                 185                 190         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        195                 200                 205             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    210                 215                 220                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
225                 230                 235                 240 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                245                 250                 255     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            260                 265                 270         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        275                 280                 285             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    290                 295                 300                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
305                 310                 315                 320 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330     


<210>  100
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VR

<400>  100

Gln Val Gln Leu Glu Glu Ser Gly Gly Arg Val Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ala Ile Ile Ser Gly Ser Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Thr Ser Lys Asn Thr Val Val Met 
65                  70                  75                  80  


Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Val Val Pro Gly Tyr Asn Ala Gly Gly Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  101
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VR

<400>  101

Glu Glu His Leu Glu Glu Ser Gly Gly Arg Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Gly Val Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ile Ile Ser Gly Ser Gly Phe Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Lys Asp Thr Ala Arg Asp Ser Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Val Val Pro Gly Tyr Asn Ala Gly Gly Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  102
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VR

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ile Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Cys Thr Ala Ala Gly Ser Val 
                85                  90                  95      


Ser Val Gly Ala Phe Gly Gly Gly Thr Glu Val Val Ile Lys 
            100                 105                 110 


<210>  103
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VR

<400>  103

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Cys Thr Ala Ala Gly Ser Val 
                85                  90                  95      


Ser Val Gly Ala Phe Gly Gln Gly Thr Glu Leu Val Ile Lys 
            100                 105                 110 


<210>  104
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VR

<400>  104

Asp Ile Glu Leu Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Ile Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Lys Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Cys Thr Ala Ala Gly Ser Val 
                85                  90                  95      


Ser Val Gly Ala Phe Gly Gly Gly Thr Lys Val Val Ile Glu 
            100                 105                 110 


