                         SEQUENCE LISTING

<110>  Weiner, David
       Elliott, Sarah
 
<120>  DNA Monoclonal Antibodies Targeting IL-6 and CD126

<130>  206108-0060-00-WO.605372

<150>  US 62/332,377
<151>  2016-05-05

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-6 1 DNA

<400>  1
atggactgga cttggaggat tctgtttctg gtcgccgccg ccactggaac tcacgccgag       60

gtgcagctgg tcgaatcagg aggaggactg gtgcagcctg gcggatctct gcggctgagt      120

tgcgccgctt caggcttcaa ctttaatgac tacttcatga actgggtcag gcaggctcca      180

ggaaaagggc tggagtgggt ggcacagatg agaaacaaga attaccagta tgggacttac      240

tatgccgagt cactggaagg caggttcacc atcagcaggg acgatagcaa aaactccctg      300

tacctgcaga tgaattctct gaagactgag gacaccgcag tgtactattg tgcccgagaa      360

tcatactatg ggttcaccag ctattggggc cagggaacac tggtcactgt gagctccgct      420

tctacaaagg gccctagcgt gttccccctg gcaccttgct ctcgcagtac ctcagagagc      480

acagcagccc tgggctgtct ggtgaaggat tacttccccg aacctgtcac cgtgtcttgg      540

aacagtggag ccctgacaag cggggtccac acttttccag ctgtgctgca gtctagtgga      600

ctgtactccc tgtcaagcgt ggtcacagtg ccatcctcta gtctggggac taaaacctat      660

acatgcaacg tggaccataa gcccagtaat accaaggtcg ataaaagggt ggagtccaag      720

tacggccctc cctgcccacc ctgtccagca ccagagttcc tgggcggccc aagcgtgttc      780

ctgtttcctc caaagcctaa agacacactg atgatcagca gaactcctga ggtcacctgc      840

gtggtcgtgg acgtgtccca ggaggacccc gaagtccagt tcaactggta cgtggatggc      900

gtcgaagtgc acaatgccaa gaccaaacca cgcgaggaac agtttaactc cacataccga      960

gtcgtgtctg tcctgactgt gctgcatcag gactggctga acggaaagga gtataagtgc     1020

aaagtgtcta acaaggggct gccctcaagc atcgagaaga caattagcaa ggcaaaaggc     1080

cagccaagag aaccccaggt gtacactctg cccccttctc aggaggaaat gactaaaaac     1140

caggtcagcc tgacctgtct ggtgaagggg ttctatccat ccgacattgc tgtggagtgg     1200

gaatctaatg gccagcccga gaacaattac aaaaccacac cacccgtgct ggactcagat     1260

ggcagcttct ttctgtatag cagactgacc gtggataagt cccggtggca ggagggaaac     1320

gtcttttcct gctctgtgat gcacgaagcc ctgcacaatc attacactca gaaaagtctg     1380

tcactgagcg gcaaacgggg acgcaagagg agatccgggt ctggcgccac caacttcagc     1440

ctgctgaagc aggctggcga cgtggaggaa aatcctggac caatggtcct gcagacacag     1500

gtgtttatca gtctgctgct gtggatttca ggggcctatg gcgatatcca gatgactcag     1560

tctccctcct ctctgagtgc ctcagtcggc gaccgggtga ctattacctg tcaggctagc     1620

caggatatcg gcattagcct gtcctggtac cagcagaagc ctggaaaagc tccaaagctg     1680

ctgatctata acgccaacaa tctggctgac ggagtgccta gccgcttctc tggaagtggg     1740

tcaggcactg actttacact gactattagt tcactgcagc ccgaggattt cgcaacctac     1800

tattgcctgc agcacaattc cgccccttac acctttggac aggggacaaa actggagatc     1860

aagcggaccg tcgctgcacc cagcgtgttc atctttcctc caagtgacga acagctgaag     1920

agcggaacag cctccgtggt gtgcctgctg aacaatttct accctcgcga ggcaaaagtc     1980

cagtggaagg tggataacgc cctgcagtcc gggaattctc aggagagtgt gaccgaacag     2040

gactcaaaag atagcacata ttccctgagc tccaccctga cactgtccaa ggctgattac     2100

gagaagcata aagtgtatgc atgcgaggtc actcaccagg ggctgtcaag tccagtcact     2160

aagtccttca atagagggga atgc                                            2184


<210>  2
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 1 Protein

<400>  2

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe 
        35                  40                  45              


Asn Asp Tyr Phe Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Gln Met Arg Asn Lys Asn Tyr Gln Tyr Gly Thr Tyr 
65                  70                  75                  80  


Tyr Ala Glu Ser Leu Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Glu Ser Tyr Tyr Gly Phe Thr Ser Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Gly 
    450                 455                 460                 


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
465                 470                 475                 480 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
                485                 490                 495     


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
            500                 505                 510         


Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
        515                 520                 525             


Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly 
    530                 535                 540                 


Ile Ser Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
545                 550                 555                 560 


Leu Ile Tyr Asn Ala Asn Asn Leu Ala Asp Gly Val Pro Ser Arg Phe 
                565                 570                 575     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            580                 585                 590         


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Ala 
        595                 600                 605             


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  3
<211>  2190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-6 2 DNA

<400>  3
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcaagctg ctgaagccag gcggctccct gaagctgtct      120

tgcgcagcaa gcggcttcac cttcagcagc ttcgccatgt cttggtttcg gcagagccca      180

gagaagcgcc tggagtgggt ggcagagatc tctagcggcg gctcttatac ctactatccc      240

gacaccgtga caggcaggtt caccatcagc agagataacg ccaagaatac actgtacctg      300

gagatgtcct ctctgcggtc cgaggacaca gccatgtact attgcgccag gggcctgtgg      360

ggatactatg cactggatta ttggggccag ggcaccagcg tgacagtgag ctccgcctcc      420

accaagggac ctagcgtgtt cccactggca ccttctagca agtctaccag cggcggcaca      480

gccgccctgg gatgtctggt gaaggactac ttccctgagc cagtgaccgt gagctggaac      540

tccggcgccc tgacctccgg agtgcacaca tttcctgccg tgctgcagtc ctctggcctg      600

tattctctga gctccgtggt gaccgtgcca tctagctccc tgggcaccca gacatacatc      660

tgcaacgtga atcacaagcc ttctaataca aaggtggaca agaaggtgga gccaaagagc      720

tgtgataaga cccacacatg ccctccctgt ccagcacctg agctgctggg cggcccaagc      780

gtgttcctgt ttccacccaa gcccaaggac accctgatga tctcccgcac cccagaggtg      840

acatgcgtgg tggtggacgt gtctcacgag gaccccgagg tgaagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta taacagcacc      960

tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tgagcaataa ggccctgcca gcccccatcg agaagaccat ctccaaggca     1080

aagggacagc caagggagcc acaggtgtat acactgcctc caagcagaga cgagctgacc     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct acccctccga tatcgccgtg     1200

gagtgggagt ctaatggcca gcctgagaac aattataaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtacagcaag ctgaccgtgg acaagtccag gtggcagcag     1320

ggcaacgtgt tttcctgctc tgtgatgcac gaggccctgc acaatcacta cacccagaag     1380

agcctgtccc tgtctccagg caagagggga aggaagagga gaagcggctc cggcgccaca     1440

aacttctccc tgctgaagca ggccggcgat gtggaggaga atcctggccc aatggtgctg     1500

cagacccagg tgtttatctc tctgctgctg tggatcagcg gcgcctacgg ccagatcgtg     1560

ctgatccaga gcccagcaat catgtctgcc agccctggag agaaggtgac catgacatgt     1620

tccgcctcta gctccgtgtc ttacatgtat tggtaccagc agaagcctgg ctctagccca     1680

cggctgctga tctatgacac atccaacctg gcatctggag tgcctgtgcg cttctccggc     1740

tctggcagcg gcacctccta ctctctgaca atctccagga tggaggccga ggatgccgcc     1800

acctactatt gccagcagtg gagcggctat ccctacacct tcggcggcgg cacaaagctg     1860

gagatcaaga gaaccgtggc cgcccctagc gtgttcatct ttccacccag cgacgagcag     1920

ctgaagagcg gcacagcctc cgtggtgtgc ctgctgaaca atttctatcc tcgggaggcc     1980

aaggtgcagt ggaaggtgga taacgccctg cagtccggca attctcagga gagcgtgacc     2040

gagcaggact ccaaggattc tacatacagc ctgtcctcta ccctgacact gtccaaggcc     2100

gactatgaga agcacaaggt gtacgcatgc gaggtgaccc accagggact gagctcccca     2160

gtgacaaaga gctttaatag aggcgagtgt                                      2190


<210>  4
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 2 Protein

<400>  4

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Leu Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Ala Met Ser Trp Phe Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
465                 470                 475                 480 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
            500                 505                 510         


Ser Gly Ala Tyr Gly Gln Ile Val Leu Ile Gln Ser Pro Ala Ile Met 
        515                 520                 525             


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser 
    530                 535                 540                 


Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro 
545                 550                 555                 560 


Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser 
            580                 585                 590         


Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
        595                 600                 605             


Gly Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
    610                 615                 620                 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
625                 630                 635                 640 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
                645                 650                 655     


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
            660                 665                 670         


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
        675                 680                 685             


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
    690                 695                 700                 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
705                 710                 715                 720 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730 


<210>  5
<211>  2190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-6 3 DNA

<400>  5
atggactgga catggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgcagcccg gcggctccct gaggctgtct      120

tgcgcagcaa gcggcttcac cttttcccct ttcgccatgt cttgggtgcg ccaggcacca      180

ggcaagggac tggagtgggt ggccaagatc tcccctggcg gctcttggac ctactattcc      240

gacaccgtga caggcaggtt tacaatcagc agagataacg ccaagaattc cctgtacctg      300

cagatgaact ctctgagggc cgaggacacc gccgtgtact attgcgccag acagctgtgg      360

ggctactatg ccctggatat ctggggccag ggcaccacag tgaccgtgag ctccgccagc      420

acaaagggcc cttccgtgtt tcccctggcc ccttctagca agtctaccag cggcggcaca      480

gccgccctgg gatgtctggt gaaggactac ttccctgagc cagtgaccgt gagctggaac      540

tccggcgccc tgacctctgg agtgcacaca tttccagccg tgctgcagtc ctctggcctg      600

tattccctga gctccgtggt gaccgtgccc tctagctccc tgggcaccca gacatacatc      660

tgcaacgtga atcacaagcc ctctaataca aaggtggaca agaaggtgga gcctaagagc      720

tgtgataaga cccacacatg ccctccctgt ccagcacctg agctgctggg cggcccaagc      780

gtgttcctgt ttccacccaa gcccaaggac acactgatga tctccaggac ccctgaggtg      840

acatgcgtgg tggtggacgt gtctcacgag gaccccgagg tgaagttcaa ctggtacgtg      900

gatggcgtgg aggtgcacaa tgccaagacc aagccacggg aggagcagta taactctacc      960

taccgcgtgg tgagcgtgct gacagtgctg caccaggatt ggctgaacgg caaggagtac     1020

aagtgcaagg tgagcaataa ggccctgcca gcccccatcg agaagaccat ctccaaggca     1080

aagggacagc cacgggagcc acaggtgtat acactgcctc caagccgcga cgagctgacc     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct acccatccga tatcgccgtg     1200

gagtgggagt ctaatggcca gcccgagaac aattataaga ccacaccccc tgtgctggac     1260

tctgatggca gcttctttct gtacagcaag ctgaccgtgg acaagtcccg gtggcagcag     1320

ggcaacgtgt tttcctgctc tgtgatgcac gaggccctgc acaatcacta cacccagaag     1380

agcctgtccc tgtctccagg caagagggga aggaagagga gaagcggctc cggcgccaca     1440

aacttcagcc tgctgaagca ggccggcgat gtggaggaga atcctggccc aatggtgctg     1500

cagacccagg tgtttatctc cctgctgctg tggatctctg gcgcctatgg agagatcgtg     1560

ctgacccagt ccccagccac actgtctctg agccctggag agagggccac cctgtcctgt     1620

tctgccagca tctccgtgtc ttacatgtat tggtaccagc agaagcctgg ccaggcccca     1680

aggctgctga tctacgacat gagcaacctg gcatccggca tccccgcaag attcagcggc     1740

tccggctctg gcaccgactt taccctgaca atctctagcc tggagcccga ggatttcgcc     1800

gtgtactatt gcatgcagtg gagcggctat ccttacacct tcggcggcgg cacaaaggtg     1860

gagatcaaga ggaccgtggc cgcccctagc gtgttcatct ttccacccag cgacgagcag     1920

ctgaagtctg gcacagccag cgtggtgtgc ctgctgaaca atttctatcc aagagaggcc     1980

aaggtgcagt ggaaggtgga taacgccctg cagtccggca attctcagga gagcgtgacc     2040

gagcaggact ccaaggattc tacatacagc ctgtcctcta ccctgacact gagcaaggcc     2100

gattatgaga agcacaaggt gtacgcatgc gaggtgaccc accagggact gagctcccca     2160

gtgacaaagt cctttaatag aggcgagtgt                                      2190


<210>  6
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 3 Protein

<400>  6

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Pro Phe Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
465                 470                 475                 480 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
            500                 505                 510         


Ser Gly Ala Tyr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
        515                 520                 525             


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ile 
    530                 535                 540                 


Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
545                 550                 555                 560 


Arg Leu Leu Ile Tyr Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            580                 585                 590         


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser 
        595                 600                 605             


Gly Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
    610                 615                 620                 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
625                 630                 635                 640 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
                645                 650                 655     


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
            660                 665                 670         


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
        675                 680                 685             


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
    690                 695                 700                 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
705                 710                 715                 720 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730 


<210>  7
<211>  2205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-6 4 DNA

<400>  7
atggattgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgg tggagagcgg cggcggcctg gtgcagcccg gcggctccct gaggctgtct      120

tgcgccgcca gcggctttag cctgtccaac tactatgtga cctgggtgag acaggcacct      180

ggcaagggac tggagtgggt gggcatcatc tacggcagcg acgagaccgc ctatgccaca      240

tccgccatcg gcaggttcac catctccaga gataactcta agaatacact gtacctgcag      300

atgaacagcc tgagggccga ggacacagcc gtgtactatt gcgccagaga cgatagctcc      360

gactgggatg ccaagttcaa tctgtggggc cagggcaccc tggtgacagt gtctagcgcc      420

tctaccaagg gaccaagcgt gtttccactg gcaccttcct ctaagtctac cagcggcggc      480

acagccgccc tgggatgtct ggtgaaggat tacttccctg agccagtgac cgtgagctgg      540

aactccggcg ccctgacctc cggagtgcac acatttccag ccgtgctgca gagctccggc      600

ctgtacagcc tgtctagcgt ggtgacagtg ccctcctcta gcctgggcac ccagacatat      660

atctgcaacg tgaatcacaa gccaagcaat accaaggtgg acaagcgggt ggagcccaag      720

tcctgtgata agacccacac atgccctccc tgtccagcac ctgagctgct gggcggccca      780

agcgtgttcc tgtttccacc caagcctaag gatacactga tgatctctcg cacccccgag      840

gtgacatgcg tggtggtgga cgtgagccac gaggaccccg aggtgaagtt caactggtac      900

gtggacggcg tggaggtgca caatgccaag accaagcctc gggaggagca gtacgcctcc      960

acctatcgcg tggtgtctgt gctgacagtg ctgcaccagg actggctgaa cggcaaggag     1020

tataagtgca aggtgtccaa taaggccctg ccagccccca tcgagaagac catctctaag     1080

gcaaagggac agccacggga gccacaggtg tacacactgc ctccatcccg cgaggagatg     1140

accaagaacc aggtgtctct gacatgtctg gtgaagggct tctatccttc tgatatcgcc     1200

gtggagtggg agagcaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg     1260

gactctgatg gcagcttctt tctgtattct aagctgaccg tggacaagag ccggtggcag     1320

cagggcaacg tgttttcctg ctctgtgatg cacgaggccc tgcacaatca ctacacacag     1380

aagagcctgt ccctgtctcc tggcaagagg ggaaggaaga ggagaagcgg ctccggagca     1440

accaacttct ccctgctgaa gcaggccggc gatgtggagg agaatcctgg cccaatggtg     1500

ctgcagacac aggtgtttat cagcctgctg ctgtggatct ccggcgccta tggcgccatc     1560

cagatgaccc agtccccatc ctctctgtct gccagcgtgg gcgacagggt gaccatcaca     1620

tgtcaggcct cccagtctat caacaatgag ctgagctggt accagcagaa gcctggcaag     1680

gccccaaagc tgctgatcta tagggcaagc accctggcat ccggagtgcc ttctagattc     1740

agcggctccg gctctggcac agactttacc ctgacaatca gctccctgca gccagacgat     1800

ttcgccacct actattgcca gcagggctac agcctgcgga acatcgataa tgccttcggc     1860

ggcggcacca aggtggagat caagcgcaca gtggccgccc catccgtgtt catctttcca     1920

ccctctgacg agcagctgaa gagcggaacc gcatccgtgg tgtgcctgct gaacaatttc     1980

taccccaggg aggccaaggt gcagtggaag gtggataacg ccctgcagtc cggcaattct     2040

caggagagcg tgaccgagca ggactccaag gattctacat atagcctgtc tagcaccctg     2100

acactgtcca aggccgacta cgagaagcac aaggtgtatg catgcgaggt gacccaccag     2160

ggactgtcct ctcccgtgac aaagagcttt aacagaggcg agtgt                     2205


<210>  8
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-6 4 Protein

<400>  8

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Asn Tyr Tyr Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Gly Ile Ile Tyr Gly Ser Asp Glu Thr Ala Tyr Ala Thr 
65                  70                  75                  80  


Ser Ala Ile Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Asp Ser Ser Asp Trp Asp Ala Lys Phe Asn Leu 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala 
465                 470                 475                 480 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
                485                 490                 495     


Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp 
            500                 505                 510         


Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser 
        515                 520                 525             


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
    530                 535                 540                 


Gln Ser Ile Asn Asn Glu Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
545                 550                 555                 560 


Ala Pro Lys Leu Leu Ile Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val 
                565                 570                 575     


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
            580                 585                 590         


Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
        595                 600                 605             


Gly Tyr Ser Leu Arg Asn Ile Asp Asn Ala Phe Gly Gly Gly Thr Lys 
    610                 615                 620                 


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
625                 630                 635                 640 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
                645                 650                 655     


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
            660                 665                 670         


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
        675                 680                 685             


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
    690                 695                 700                 


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
705                 710                 715                 720 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735 


<210>  9
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD126 1 DNA

<400>  9
atggactgga catggagaat cctgttcctg gtcgccgccg caaccgggac tcacgcagaa       60

gtgcagctgg tcgaaagtgg agggggcctg gtgcagcccg gccgaagtct gaggctgtca      120

tgcgccgcta gccgattcac ctttgacgat tacgctatgc actgggtgag gcaggcacct      180

ggaaaagggc tggagtgggt cagcggcatc tcctggaact ctggccggat tggatatgct      240

gacagcgtga agggaagatt cacaatctcc cgggataacg cagaaaattc tctgtttctg      300

cagatgaatg ggctgagagc agaggacact gccctgtact attgcgccaa gggccgggac      360

agcttcgata tttggggcca gggaaccatg gtcacagtga gctccgcaag caccaaaggc      420

ccctccgtgt ttcccctggc cccttctagt aagtccactt ctggcggaac cgcagccctg      480

ggatgtctgg tgaaggatta cttccctgag ccagtcacag tgagttggaa ctcaggcgcc      540

ctgaccagcg gagtgcatac atttcctgct gtcctgcagt caagcgggct gtacagcctg      600

tcctctgtgg tcaccgtgcc aagttcaagc ctgggcactc agacctatat ctgcaacgtg      660

aatcacaaac catccaatac aaaggtcgac aagaaagtgg aacccaaatc ttgtgataag      720

acacatactt gccctccctg tccagcacct gagctgctgg gcggcccaag cgtgttcctg      780

tttccaccca agcctaaaga caccctgatg attagccgca cacccgaagt gacttgcgtg      840

gtcgtggacg tgagccacga ggaccccgaa gtgaagttca actggtacgt ggatggcgtc      900

gaggtgcata atgctaagac aaaacccagg gaggaacagt acaactctac ctatagagtc      960

gtgagtgtcc tgacagtgct gcaccaggac tggctgaacg ggaaggagta taagtgcaaa     1020

gtgtccaaca aggccctgcc agctcccatc gagaagacaa tttctaaggc caaaggccag     1080

ccacgggaac cccaggtgta cactctgcct ccaagccgcg acgagctgac aaaaaaccag     1140

gtgagcctga cttgtctggt caagggattc tatccttctg atatcgctgt ggagtgggaa     1200

agtaatgggc agccagaaaa caattacaag accacacccc ctgtgctgga cagcgatggc     1260

agcttcttcc tgtatagtaa actgaccgtg gacaagtcaa ggtggcagca ggggaacgtg     1320

tttagttgct cagtcatgca tgaggccctg cacaatcatt acactcagaa aagcctgtcc     1380

ctgtctcctg ggaaacgggg ccgcaagagg agaagtgggt caggcgctac aaacttctcc     1440

ctgctgaagc aggcagggga tgtggaggaa aatcctggcc caatggtgct gcagacccag     1500

gtctttatct cactgctgct gtggattagc ggagcctatg gggacatcca gatgacacag     1560

tcccccagca gcgtgagcgc ctccgtgggc gatcgcgtca ccatcacatg tcgagcctct     1620

cagggaatta gttcatggct ggcttggtac cagcagaagc ctggcaaagc accaaagctg     1680

ctgatctatg gagccagctc cctggaatcc ggggtgccat ctagattctc tggaagtggg     1740

tcaggcaccg actttactct gaccatttct agtctgcagc cagaggattt cgcctcctac     1800

tattgccagc aggctaactc tttcccctac acttttggac aggggaccaa actggaaatc     1860

aagcgcactg tggctgcacc aagcgtcttc atttttccac cctccgacga gcagctgaag     1920

agtggaaccg cctcagtggt gtgcctgctg aacaacttct acccccgaga agcaaaagtg     1980

cagtggaagg tcgataacgc cctgcagtct ggcaatagtc aggagtcagt gactgaacag     2040

gacagcaaag attccaccta ttctctgtca agcacactga ctctgagcaa ggctgactac     2100

gagaagcaca aagtgtatgc atgcgaagtg acccaccagg ggctgagcag tccagtgacc     2160

aagtctttca atagaggaga atgc                                            2184


<210>  10
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD126 1 Protein

<400>  10

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn 
                85                  90                  95      


Ser Leu Phe Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly 
        115                 120                 125             


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
465                 470                 475                 480 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
                485                 490                 495     


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
            500                 505                 510         


Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser 
        515                 520                 525             


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser 
    530                 535                 540                 


Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
545                 550                 555                 560 


Leu Ile Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe 
                565                 570                 575     


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
            580                 585                 590         


Gln Pro Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe 
        595                 600                 605             


Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  11
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD126 2 DNA

<400>  11
atggattgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcacag       60

gtgcagctgc aggagtccgg accaggactg gtgcgcccaa gccagaccct gtccctgacc      120

tgcacagtga gcggctactc catcacatct gaccacgcct ggagctgggt gcggcagccc      180

cctggaaggg gactggagtg gatcggctac atctcttata gcggcatcac cacatataac      240

ccaagcctga agtccagggt gaccatgctg agagacacat ccaagaatca gttctctctg      300

aggctgagct ccgtgaccgc agcagataca gccgtgtact attgcgccag gtctctggcc      360

agaaccacag ccatggacta ctggggacag ggcagcctgg tgaccgtgtc tagcgccagc      420

acaaagggac catccgtgtt tccactggca ccctcctcta agtccacctc tggcggcaca      480

gccgccctgg gctgtctggt gaaggattat ttccccgagc ctgtgaccgt gtcttggaac      540

agcggcgccc tgacctccgg agtgcacaca tttccagccg tgctgcagag ctccggcctg      600

tacagcctgt ctagcgtggt gaccgtgccc tcctctagcc tgggcaccca gacatatatc      660

tgcaacgtga atcacaagcc ctctaataca aaggtggaca agaaggtgga gcctaagagc      720

tgtgataaga cccacacatg cccaccctgt ccagcaccag agctgctggg cggcccttcc      780

gtgttcctgt ttcctccaaa gccaaaggat accctgatga tctcccggac ccctgaggtg      840

acatgcgtgg tggtggacgt gtctcacgag gaccccgagg tgaagttcaa ctggtacgtg      900

gacggcgtgg aggtgcacaa tgccaagacc aagcctcggg aggagcagta caactctacc      960

tatcgcgtgg tgagcgtgct gacagtgctg caccaggact ggctgaacgg caaggagtat     1020

aagtgcaagg tgagcaataa ggccctgcct gccccaatcg agaagaccat ctccaaggcc     1080

aagggccagc ctagggagcc acaggtgtac acactgcccc ctagcagaga ggagatgacc     1140

aagaaccagg tgtccctgac atgtctggtg aagggcttct atccatccga tatcgccgtg     1200

gagtgggagt ctaatggcca gcccgagaac aattacaaga ccacaccacc cgtgctggac     1260

tccgatggct ctttctttct gtatagcaag ctgaccgtgg acaagtcccg ctggcagcag     1320

ggcaacgtgt ttagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1380

tctctgagcc tgtccccagg caagagggga aggaagagga gatctggcag cggcgccaca     1440

aacttcagcc tgctgaagca ggcaggcgat gtggaggaga atccaggacc tatggtgctg     1500

cagacccagg tgtttatctc cctgctgctg tggatctctg gcgcctacgg cgacatccag     1560

atgacacagt ccccctcctc tctgtccgcc tctgtgggcg acagggtgac catcacatgt     1620

cgcgccagcc aggatatcag ctcctacctg aactggtatc agcagaagcc cggcaaggcc     1680

cctaagctgc tgatctacta tacctctagg ctgcacagcg gcgtgccttc cagattcagc     1740

ggctccggct ctggcaccga cttcaccttt acaatctcta gcctgcagcc cgaggatatc     1800

gccacatact attgccagca gggcaatacc ctgccttaca catttggcca gggcaccaag     1860

gtggagatca agaggacagt ggccgcccct agcgtgttca tctttcctcc aagcgatgag     1920

cagctgaagt ctggcaccgc cagcgtggtg tgcctgctga acaatttcta cccaagagag     1980

gccaaggtgc agtggaaggt ggacaacgcc ctgcagagcg gcaattccca ggagtctgtg     2040

accgagcagg acagcaagga ttccacatat tctctgtcct ctaccctgac actgtccaag     2100

gccgactacg agaagcacaa ggtgtatgca tgcgaggtga cccaccaggg actgagctcc     2160

ccagtgacaa agagctttaa cagaggcgag tgt                                  2193


<210>  12
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD126 2 Protein

<400>  12

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile 
        35                  40                  45              


Thr Ser Asp His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn 
65                  70                  75                  80  


Pro Ser Leu Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn 
                85                  90                  95      


Gln Phe Ser Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
465                 470                 475                 480 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
            500                 505                 510         


Ser Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
        515                 520                 525             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    530                 535                 540                 


Asp Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
545                 550                 555                 560 


Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro 
                565                 570                 575     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile 
            580                 585                 590         


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly 
        595                 600                 605             


Asn Thr Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


