                         SEQUENCE LISTING

<110>  Exicure, Inc.
 
<120>  LIPOSOMAL SPHERICAL NUCLEIC ACID (SNA) CONSTRUCTS PRESENTING 
       ANTISENSE OLIGONUCLEOTIDES (ASO) FOR SPECIFIC KNOCKDOWN OF 
       INTERLEUKIN 17 RECEPTOR MRNA

<130>  A1107.70015WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/333,082
<151>  2016-05-06

<160>  311   

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
gctgcacttt ggagtgatcg                                                   20


<210>  2
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
gtttgctaca acatgggcta cag                                               23


<210>  3
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Modified with 6-fluorescein amidite (FAM)

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Modified with black hole quencher 1 (BHQ1) 

<400>  3
cccaggcagt cagatcatct tctcga                                            26


<210>  4
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
caaggtcatc catgacaact ttg                                               23


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
gggccatcca cagtcttct                                                    19


<210>  6
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Modified with Hexachloro-Fluorescein (HEX)

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Modified with black hole quencher 1 (BHQ1) 

<400>  6
accacagtcc atgccatcac tgcca                                             25


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  7
ucgcggaggg ctcggccc                                                     18


<210>  8
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with an O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with an O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  8
gucgcggagg gcucggcc                                                     18


<210>  9
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  9
cgucgcggag ggcucggc                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  10
acggcgggct gcgugcgg                                                     18


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  11
gacggcgggc tgcgugcg                                                     18


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  12
acucugcacc ctcgaggu                                                     18


<210>  13
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  13
gggcugccca gcagcggg                                                     18


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  14
ugugugggtc tgugagga                                                     18


<210>  15
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  15
ggcgugtgtg ggucugug                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  16
gggcgugtgt gggucugu                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  17
agggcgtgtg tgggucug                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  18
uagggcgtgt gtgggucu                                                     18


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  19
agcucctgga gauguagc                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  20
gagcucctgg agauguag                                                     18


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  21
ggagcucctg gagaugua                                                     18


<210>  22
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  22
cccucggggg gcugcggg                                                     18


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  23
gggagagagt ggcagggc                                                     18


<210>  24
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  24
cgggagagag tggcaggg                                                     18


<210>  25
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  25
acgauaacca gaccgcug                                                     18


<210>  26
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  26
gggagcgggc tgugugga                                                     18


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  27
acauagtagg tgcacaau                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  28
cacauagtag gtgcacaa                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  29
gggucucact ctgcugcc                                                     18


<210>  30
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  30
gggcaggctt ccacucca                                                     18


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  31
aaagcugtta ggaggaca                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  32
uaaagctgtt aggaggac                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  33
auaaagctgt taggagga                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  34
accggcatca aauugugc                                                     18


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  35
aaccggcatc aaauugug                                                     18


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  36
cuggauttct ttuggggg                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  37
gcuggatttc ttuugggg                                                     18


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  38
ggcuggattt ctuuuggg                                                     18


<210>  39
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  39
gggcuggatt tcuuuugg                                                     18


<210>  40
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  40
ggggcuggat ttcuuuug                                                     18


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  41
gggagggaat gtgaggag                                                     18


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  42
gcugaagagg tgggaggg                                                     18


<210>  43
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  43
gagccuggga ggucgagg                                                     18


<210>  44
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  44
gggaggatga ggcgggca                                                     18


<210>  45
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  45
ugggaggatg aggcgggc                                                     18


<210>  46
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  46
uuuaggaagg ggagcacc                                                     18


<210>  47
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  47
auuuaggaag gggagcac                                                     18


<210>  48
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  48
uauuuaggaa ggggagca                                                     18


<210>  49
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  49
uuauuuagga aggggagc                                                     18


<210>  50
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  50
cauuuattta ggaagggg                                                     18


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  51
ucauuuattt aggaaggg                                                     18


<210>  52
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  52
gggaugcagg cccggcug                                                     18


<210>  53
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  53
aaagaggatc agugguac                                                     18


<210>  54
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  54
gaaagaggat caguggua                                                     18


<210>  55
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  55
uggguutagg gguagcug                                                     18


<210>  56
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  56
auggguttag ggguagcu                                                     18


<210>  57
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  57
aaugggttta gggguagc                                                     18


<210>  58
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  58
ugcaaugggt ttaggggu                                                     18


<210>  59
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  59
gugcaatggg ttuagggg                                                     18


<210>  60
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  60
ugugcaatgg gtuuaggg                                                     18


<210>  61
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  61
uugugcaatg gguuuagg                                                     18


<210>  62
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  62
cuugugcaat ggguuuag                                                     18


<210>  63
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  63
gcuugugcaa tggguuua                                                     18


<210>  64
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  64
agcuugtgca atggguuu                                                     18


<210>  65
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  65
cagcuugtgc aauggguu                                                     18


<210>  66
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  66
gggcauggag agccaugc                                                     18


<210>  67
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  67
ucugggagag gcgauggg                                                     18


<210>  68
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  68
gggaggtggg ctgggcca                                                     18


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  69
acuccctctc ctccuccu                                                     18


<210>  70
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  70
uacuccctct ccuccucc                                                     18


<210>  71
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  71
gggaggcaag gtcugaga                                                     18


<210>  72
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  72
ucagggcagc ccgggagg                                                     18


<210>  73
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  73
cacuccactc accuccca                                                     18


<210>  74
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  74
gggugcaggg ctucagac                                                     18


<210>  75
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  75
gcgggugcag ggcuucag                                                     18


<210>  76
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  76
cuguuugctc tccuguca                                                     18


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  77
ccuguutgct ctccuguc                                                     18


<210>  78
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  78
uccuguttgc tcuccugu                                                     18


<210>  79
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  79
guccugtttg ctcuccug                                                     18


<210>  80
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  80
uguccugttt gcucuccu                                                     18


<210>  81
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  81
cugucctgtt tgcucucc                                                     18


<210>  82
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  82
ggcuagtggc tgggaggc                                                     18


<210>  83
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  83
ggaaugggag cagauggg                                                     18


<210>  84
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  84
gggcuugggc agguggug                                                     18


<210>  85
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  85
gggaugggct tgggcagg                                                     18


<210>  86
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  86
ggucuccacg gtgauguu                                                     18


<210>  87
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  87
guaaugggta gauucguu                                                     18


<210>  88
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  88
gguaaugggt agauucgu                                                     18


<210>  89
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  89
ugguaatggg tagauucg                                                     18


<210>  90
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  90
cugguaatgg gtagauuc                                                     18


<210>  91
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  91
gggcgcaggt atguggug                                                     18


<210>  92
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  92
ggcugagtag atgaucca                                                     18


<210>  93
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  93
cgcgccgaac aggucggg                                                     18


<210>  94
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  94
guagaggttc tcacauuc                                                     18


<210>  95
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  95
ccgcccgggc tccgcagg                                                     18


<210>  96
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  96
cccugggcag gcuuccac                                                     18


<210>  97
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  97
caaugggttt agggguag                                                     18


<210>  98
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  98
gcaaugggtt taggggua                                                     18


<210>  99
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  99
ggaggatgag gcgggcag                                                     18


<210>  100
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  100
gugcggcccc cauggccc                                                     18


<210>  101
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  101
cgugcggccc ccauggcc                                                     18


<210>  102
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  102
gcgugcggcc cccauggc                                                     18


<210>  103
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  103
ugcgugcggc ccccaugg                                                     18


<210>  104
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  104
cugcgugcgg cccccaug                                                     18


<210>  105
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  105
cgggcugcgt gcggcccc                                                     18


<210>  106
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  106
gcgggctgcg tgcggccc                                                     18


<210>  107
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  107
ggcgggctgc gtgcggcc                                                     18


<210>  108
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  108
ucgcagggag gcgccacc                                                     18


<210>  109
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  109
gucgcaggga ggcgccac                                                     18


<210>  110
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  110
uucgaugtga gccacggg                                                     18


<210>  111
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  111
ccauucgatg tgagccac                                                     18


<210>  112
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  112
gauaactctg cacccucg                                                     18


<210>  113
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  113
ggcuugggca ggugguga                                                     18


<210>  114
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  114
ugggcutggg cagguggu                                                     18


<210>  115
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  115
aaugggtaga ttcguucc                                                     18


<210>  116
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  116
uaaugggtag atucguuc                                                     18


<210>  117
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  117
ucccccgcca gtgccagc                                                     18


<210>  118
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  118
cccucugact ctgacccc                                                     18


<210>  119
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  119
gggcccctct gacucuga                                                     18


<210>  120
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  120
ugggcccctc tgacucug                                                     18


<210>  121
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  121
cugggcccct ctgacucu                                                     18


<210>  122
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  122
aggguctcac tcugcugc                                                     18


<210>  123
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  123
caggguctca ctcugcug                                                     18


<210>  124
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  124
acagggtctc acucugcu                                                     18


<210>  125
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  125
gacagggtct cacucugc                                                     18


<210>  126
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  126
agacagggtc tcacucug                                                     18


<210>  127
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  127
gagacagggt ctcacucu                                                     18


<210>  128
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  128
ugagacaggg tcucacuc                                                     18


<210>  129
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  129
gcaggcttcc acuccauc                                                     18


<210>  130
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  130
cuccactcac ctcccagc                                                     18


<210>  131
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  131
acuccactca ccucccag                                                     18


<210>  132
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  132
gcucactcca ctcaccuc                                                     18


<210>  133
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  133
agcucactcc acucaccu                                                     18


<210>  134
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  134
gacaagctca ctccacuc                                                     18


<210>  135
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  135
uccccccacc ccccaccc                                                     18


<210>  136
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  136
agggcutcag acucaccu                                                     18


<210>  137
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  137
cagggcttca gacucacc                                                     18


<210>  138
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  138
gcagggcttc agacucac                                                     18


<210>  139
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  139
ugcagggctt cagacuca                                                     18


<210>  140
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  140
gugcagggct tcagacuc                                                     18


<210>  141
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  141
cgggugcagg gcuucaga                                                     18


<210>  142
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  142
cgcgggtgca gggcuuca                                                     18


<210>  143
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  143
acgcgggtgc agggcuuc                                                     18


<210>  144
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  144
aacgcgggtg cagggcuu                                                     18


<210>  145
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  145
gaacgcgggt gcagggcu                                                     18


<210>  146
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  146
cucucctgtc acauuucc                                                     18


<210>  147
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  147
gcucucctgt cacauuuc                                                     18


<210>  148
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  148
ugcucucctg tcacauuu                                                     18


<210>  149
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  149
uugcuctcct gtcacauu                                                     18


<210>  150
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  150
uuugcuctcc tgucacau                                                     18


<210>  151
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  151
guuugctctc ctgucaca                                                     18


<210>  152
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  152
uguuugctct ccugucac                                                     18


<210>  153
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  153
ccuguutgct ctccuguc                                                     18


<210>  154
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  154
agcugaagag gtgggagg                                                     18


<210>  155
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  155
gagcugaaga ggugggag                                                     18


<210>  156
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a  O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  156
cgagcugaag agguggga                                                     18


<210>  157
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  157
acgagctgaa gagguggg                                                     18


<210>  158
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  158
ggcaggcttc cacuccau                                                     18


<210>  159
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  159
ugggcaggct tccacucc                                                     18


<210>  160
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  160
cugggcaggc ttccacuc                                                     18


<210>  161
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  161
ccugggcagg ctuccacu                                                     18


<210>  162
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  162
ccaccuctgc acacucag                                                     18


<210>  163
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  163
gccugggagg tcgaggcu                                                     18


<210>  164
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  164
agccugggag gtcgaggc                                                     18


<210>  165
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  165
ugagcctggg aggucgag                                                     18


<210>  166
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  166
uugagcctgg gaggucga                                                     18


<210>  167
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  167
cuugagcctg ggaggucg                                                     18


<210>  168
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  168
uugggaggat gaggcggg                                                     18


<210>  169
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  169
uuugggagga tgaggcgg                                                     18


<210>  170
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  170
gugggatgca ggcccggc                                                     18


<210>  171
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  171
ugugggatgc aggcccgg                                                     18


<210>  172
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  172
uugugggatg caggcccg                                                     18


<210>  173
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  173
acuccugccc cacccacu                                                     18


<210>  174
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  174
aggcuggtgc cacucggg                                                     18


<210>  175
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  175
gaggaucagt gguaccuc                                                     18


<210>  176
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  176
aagaggatca gtgguacc                                                     18


<210>  177
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  177
gcauggagag ccaugcag                                                     18


<210>  178
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  178
gggaaagagg atcagugg                                                     18


<210>  179
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  179
agggaaagag gaucagug                                                     18


<210>  180
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  180
cauggagagc caugcaga                                                     18


<210>  181
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  181
ggcauggaga gccaugca                                                     18


<210>  182
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  182
ggggcatgga gagccaug                                                     18


<210>  183
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  183
uggggcatgg agagccau                                                     18


<210>  184
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  184
auggggcatg gagagcca                                                     18


<210>  185
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  185
aucugggaga ggcgaugg                                                     18


<210>  186
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  186
gaucugggag aggcgaug                                                     18


<210>  187
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  187
ggaucuggga gaggcgau                                                     18


<210>  188
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  188
cccucucctc ctccuacc                                                     18


<210>  189
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  189
ucccuctcct ccuccuac                                                     18


<210>  190
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  190
cucccuctcc tccuccua                                                     18


<210>  191
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  191
cuacuccctc tccuccuc                                                     18


<210>  192
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  192
ucuacuccct ctccuccu                                                     18


<210>  193
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  193
uucuactccc tcuccucc                                                     18


<210>  194
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  194
uuucuactcc ctcuccuc                                                     18


<210>  195
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  195
cuuucuactc ccucuccu                                                     18


<210>  196
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  196
ccuuuctact cccucucc                                                     18


<210>  197
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  197
cuccuutcta ctcccucu                                                     18


<210>  198
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  198
ucccuccttt ctacuccc                                                     18


<210>  199
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  199
ucccucgtca cagccacc                                                     18


<210>  200
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  200
gcucuctctg ccucucgu                                                     18


<210>  201
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  201
gagcuctctc tgccucuc                                                     18


<210>  202
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  202
gggcuucaga ctcaccuu                                                     18


<210>  203
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  203
cuccgcaggt aguugucc                                                     18


<210>  204
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  204
ggcuccgcag gtaguugu                                                     18


<210>  205
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  205
gggcuccgca gguaguug                                                     18


<210>  206
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  206
acacccacag gggcaugu                                                     18


<210>  207
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  207
uccccgacca gcgggucu                                                     18


<210>  208
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  208
cuccccgacc agcggguc                                                     18


<210>  209
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  209
cguagggcgt gtgugggu                                                     18


<210>  210
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  210
ucguagggcg tguguggg                                                     18


<210>  211
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  211
cucguagggc gtgugugg                                                     18


<210>  212
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  212
ccucguaggg cgugugug                                                     18


<210>  213
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with/iSp18//iSp18//3CholTEG/

<400>  213
uccucgtagg gcgugugu                                                     18


<210>  214
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  214
cuccucgtag ggcgugug                                                     18


<210>  215
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  215
gggcgucaaa caguuauu                                                     18


<210>  216
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  216
uccaauaaag ctguuagg                                                     18


<210>  217
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  217
cuccaataaa gcuguuag                                                     18


<210>  218
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  218
acuccaataa agcuguua                                                     18


<210>  219
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  219
uacuccaata aagcuguu                                                     18


<210>  220
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  220
ugcccuattt aauuuuca                                                     18


<210>  221
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  221
augccctatt taauuuuc                                                     18


<210>  222
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  222
uaugccctat ttaauuuu                                                     18


<210>  223
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  223
cucauutatt taggaagg                                                     18


<210>  224
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  224
ccucauttat ttaggaag                                                     18


<210>  225
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  225
gcuugggcag gtggugaa                                                     18


<210>  226
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  226
uccacucacc tcccagca                                                     18


<210>  227
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  227
ucacuccact caccuccc                                                     18


<210>  228
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  228
uccccacccc tgagcucu                                                     18


<210>  229
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  229
agaggatcag tgguaccu                                                     18


<210>  230
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  230
gcuccgcagg taguuguc                                                     18


<210>  231
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  231
cucacuccac tcaccucc                                                     18


<210>  232
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  232
augggcttgg gcaggugg                                                     18


<210>  233
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  233
auggguagat tcguucca                                                     18


<210>  234
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  234
cacucutgaa gcucuugg                                                     18


<210>  235
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  235
cgucaaacag ttauuuau                                                     18


<210>  236
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  236
ggcuggattt ctuuuggg                                                     18


<210>  237
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  237
cuccucgtag ggcgugug                                                     18


<210>  238
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  238
ggcaggtggt gaacgguc                                                     18


<210>  239
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  239
gggcaggtgg tgaacggu                                                     18


<210>  240
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  240
ugggcaggtg gtgaacgg                                                     18


<210>  241
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  241
uugggcaggt ggugaacg                                                     18


<210>  242
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  242
cuugggcagg tggugaac                                                     18


<210>  243
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  243
cacaggggca tguagucc                                                     18


<210>  244
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  244
ccacaggggc atguaguc                                                     18


<210>  245
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  245
cccacagggg cauguagu                                                     18


<210>  246
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  246
cacccacagg ggcaugua                                                     18


<210>  247
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  247
uacacccaca ggggcaug                                                     18


<210>  248
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  248
guacacccac aggggcau                                                     18


<210>  249
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  249
aguacaccca caggggca                                                     18


<210>  250
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  250
caguacaccc acaggggc                                                     18


<210>  251
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  251
ccaguacacc cacagggg                                                     18


<210>  252
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  252
guagggcgtg tguggguc                                                     18


<210>  253
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  253
ccuccucgta gggcgugu                                                     18


<210>  254
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  254
uccucctcgt agggcgug                                                     18


<210>  255
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  255
cuccucctcg tagggcgu                                                     18


<210>  256
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  256
gcuccucctc gtagggcg                                                     18


<210>  257
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  257
gcutgggcag gtggtgaa                                                     18


<210>  258
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  258
ucctcgtagg gcgtgugu                                                     18


<210>  259
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  259
gcuugggcag gtggugaa                                                     18


<210>  260
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  260
acacccacag gggcaugu                                                     18


<210>  261
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  261
cguagggcgt gtgtgggu                                                     18


<210>  262
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  262
uccucgtagg gcgtgugu                                                     18


<210>  263
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  263
gcuugggcag gtggugaa                                                     18


<210>  264
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  264
acacccacag gggcaugu                                                     18


<210>  265
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  265
cguagggcgt gtgugggu                                                     18


<210>  266
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  266
uccucgtagg gcgugugu                                                     18


<210>  267
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (10)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  267
gcuugggcag gtggtgaa                                                     18


<210>  268
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (10)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  268
acacccacag gggcaugu                                                     18


<210>  269
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (10)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  269
uccucguagg gcgtgugu                                                     18


<210>  270
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  270
gcutgggcag guggugaa                                                     18


<210>  271
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  271
acacccacag gggcaugu                                                     18


<210>  272
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  272
cguagggcgu gugugggu                                                     18


<210>  273
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  273
ucctcgtagg gcgugugu                                                     18


<210>  274
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  274
gcuugggcag gtggugaa                                                     18


<210>  275
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  275
acacccacag gggcaugu                                                     18


<210>  276
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  276
cguagggcgt gtgugggu                                                     18


<210>  277
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  277
uccucguagg gcgugugu                                                     18


<210>  278
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  278
gcuugggcag guggugaa                                                     18


<210>  279
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  279
acacccacag gggcaugu                                                     18


<210>  280
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  280
cguagggcgt gugugggu                                                     18


<210>  281
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  281
uccucgtagg gcgugugu                                                     18


<210>  282
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  282
acacccacag gggcaugu                                                     18


<210>  283
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  283
cguagggcgt gtgtgggu                                                     18


<210>  284
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  284
acccacaggg gcauguag                                                     18


<210>  285
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (10)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/


<400>  285
cguagggcgt gtgtgggu                                                     18


<210>  286
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (10)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  286
cccacagggg catgtagu                                                     18


<210>  287
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  287
cccacagggg cauguagu                                                     18


<210>  288
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  288
cccacagggg catguagu                                                     18


<210>  289
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(7)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (8)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  289
guagggcgtg tgtggguc                                                     18


<210>  290
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  290
guagggcgtg uguggguc                                                     18


<210>  291
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (10)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  291
guagggcgug tgtggguc                                                     18


<210>  292
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(12)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (12)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  292
guagggcgtg tguggguc                                                     18


<210>  293
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(10)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (10)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  293
cccacagggg cauguagu                                                     18


<210>  294
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  294
guagggcgtg tgtggguc                                                     18


<210>  295
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  295
guagggcgtg tgtggguc                                                     18


<210>  296
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (4)..(16)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  296
cccacagggg catgtagu                                                     18


<210>  297
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (5)..(15)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/


<400>  297
cccacagggg catguagu                                                     18


<210>  298
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  298
cccacagggg catguagu                                                     18


<210>  299
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (6)..(14)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (14)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  299
guagggcgtg tgtggguc                                                     18


<210>  300
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  300
guuucaccac ccaauucc                                                     18


<210>  301
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Modified with a phosphorothioate bond

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  Modified with a O methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Modified with /iSp18//iSp18//3CholTEG/

<400>  301
ugggagtaga caagguac                                                     18


<210>  302
<211>  8608
<212>  DNA
<213>  Homo sapiens

<400>  302
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg       60

aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga      120

cgccagccgg gccatggggg ccgcacgcag cccgccgtcc gctgtcccgg ggcccctgct      180

ggggctgctc ctgctgctcc tgggcgtgct ggccccgggt ggcgcctccc tgcgactcct      240

ggaccaccgg gcgctggtct gctcccagcc ggggctaaac tgcacggtca agaatagtac      300

ctgcctggat gacagctgga ttcaccctcg aaacctgacc ccctcctccc caaaggacct      360

gcagatccag ctgcactttg cccacaccca acaaggagac ctgttccccg tggctcacat      420

cgaatggaca ctgcagacag acgccagcat cctgtacctc gagggtgcag agttatctgt      480

cctgcagctg aacaccaatg aacgtttgtg cgtcaggttt gagtttctgt ccaaactgag      540

gcatcaccac aggcggtggc gttttacctt cagccacttt gtggttgacc ctgaccagga      600

atatgaggtg accgttcacc acctgcccaa gcccatccct gatggggacc caaaccacca      660

gtccaagaat ttccttgtgc ctgactgtga gcacgccagg atgaaggtaa ccacgccatg      720

catgagctca ggcagcctgt gggaccccaa catcaccgtg gagaccctgg aggcccacca      780

gctgcgtgtg agcttcaccc tgtggaacga atctacccat taccagatcc tgctgaccag      840

ttttccgcac atggagaacc acagttgctt tgagcacatg caccacatac ctgcgcccag      900

accagaagag ttccaccagc gatccaacgt cacactcact ctacgcaacc ttaaagggtg      960

ctgtcgccac caagtgcaga tccagccctt cttcagcagc tgcctcaatg actgcctcag     1020

acactccgcg actgtttcct gcccagaaat gccagacact ccagaaccaa ttccggacta     1080

catgcccctg tgggtgtact ggttcatcac gggcatctcc atcctgctgg tgggctccgt     1140

catcctgctc atcgtctgca tgacctggag gctagctggg cctggaagtg aaaaatacag     1200

tgatgacacc aaatacaccg atggcctgcc tgcggctgac ctgatccccc caccgctgaa     1260

gcccaggaag gtctggatca tctactcagc cgaccacccc ctctacgtgg acgtggtcct     1320

gaaattcgcc cagttcctgc tcaccgcctg cggcacggaa gtggccctgg acctgctgga     1380

agagcaggcc atctcggagg caggagtcat gacctgggtg ggccgtcaga agcaggagat     1440

ggtggagagc aactctaaga tcatcgtcct gtgctcccgc ggcacgcgcg ccaagtggca     1500

ggcgctcctg ggccgggggg cgcctgtgcg gctgcgctgc gaccacggaa agcccgtggg     1560

ggacctgttc actgcagcca tgaacatgat cctcccggac ttcaagaggc cagcctgctt     1620

cggcacctac gtagtctgct acttcagcga ggtcagctgt gacggcgacg tccccgacct     1680

gttcggcgcg gcgccgcggt acccgctcat ggacaggttc gaggaggtgt acttccgcat     1740

ccaggacctg gagatgttcc agccgggccg catgcaccgc gtaggggagc tgtcggggga     1800

caactacctg cggagcccgg gcggcaggca gctccgcgcc gccctggaca ggttccggga     1860

ctggcaggtc cgctgtcccg actggttcga atgtgagaac ctctactcag cagatgacca     1920

ggatgccccg tccctggacg aagaggtgtt tgaggagcca ctgctgcctc cgggaaccgg     1980

catcgtgaag cgggcgcccc tggtgcgcga gcctggctcc caggcctgcc tggccataga     2040

cccgctggtc ggggaggaag gaggagcagc agtggcaaag ctggaacctc acctgcagcc     2100

ccggggtcag ccagcgccgc agcccctcca caccctggtg ctcgccgcag aggagggggc     2160

cctggtggcc gcggtggagc ctgggcccct ggctgacggt gccgcagtcc ggctggcact     2220

ggcgggggag ggcgaggcct gcccgctgct gggcagcccg ggcgctgggc gaaatagcgt     2280

cctcttcctc cccgtggacc ccgaggactc gccccttggc agcagcaccc ccatggcgtc     2340

tcctgacctc cttccagagg acgtgaggga gcacctcgaa ggcttgatgc tctcgctctt     2400

cgagcagagt ctgagctgcc aggcccaggg gggctgcagt agacccgcca tggtcctcac     2460

agacccacac acgccctacg aggaggagca gcggcagtca gtgcagtctg accagggcta     2520

catctccagg agctccccgc agccccccga gggactcacg gaaatggagg aagaggagga     2580

agaggagcag gacccaggga agccggccct gccactctct cccgaggacc tggagagcct     2640

gaggagcctc cagcggcagc tgcttttccg ccagctgcag aagaactcgg gctgggacac     2700

gatggggtca gagtcagagg ggcccagtgc atgagggcgg ctccccaggg accgcccaga     2760

tcccagcttt gagagaggag tgtgtgtgca cgtattcatc tgtgtgtaca tgtctgcatg     2820

tgtatatgtt cgtgtgtgaa atgtaggctt taaaatgtaa atgtctggat tttaatccca     2880

ggcatccctc ctaacttttc tttgtgcagc ggtctggtta tcgtctatcc ccaggggaat     2940

ccacacagcc cgctcccagg agctaatggt agagcgtcct tgaggctcca ttattcgttc     3000

attcagcatt tattgtgcac ctactatgtg gcgggcattt gggataccaa gataaattgc     3060

atgcggcatg gccccagcca tgaaggaact taaccgctag tgccgaggac acgttaaacg     3120

aacaggatgg gccgggcacg gtggctcacg cctgtaatcc cagcacactg ggaggccgag     3180

gcaggtggat cactctgagg tcaggagttt gagccagcct ggccaacatg gtgaaacccc     3240

atctccacta aaaatagaaa aattagccgg gcatggtgac acatgcctgt agtcctagct     3300

acttgggagg ctgaggcagg agaattgctt gaatctggga ggcagaggtt gcagtgagcc     3360

gagattgtgc cattgcactg cagcctggat gacagagcga gactctatct caaaaaaaaa     3420

aaaaaaaaaa gatggtcacg cgggatgtaa acgctgaatg ggccaggtgc agtggctcat     3480

gcttgtaatc ccagcacttt gggaaggcga ggcaggtgga ttgcttgagc tcaggagttc     3540

aagaccagcc tgggcgacat agtgagacct catctctacc taaatttttt tttagtcagt     3600

catggtggca catgcctgta gtcccagcta ctcgggaggc tgatgccaga tgatcacttg     3660

agcccaggag gtagaggctg cagtgagcta taatggtacc attgcaatcc agcctgggca     3720

gcagagtgag accctgtctc aaaaaaaata aaaaagtaga aagatggagt ggaagcctgc     3780

ccagggttgt gagcatgcac gggaaaggca cccaggtcag gggggatccc cgaggagatg     3840

cctgagctga aggattgtgg ttggggaaag cgtagtccca gcaaggaagc agtttgtggg     3900

taagtgctgg gaggtgagtg gagtgagctt gtcagggagc tgctggtgga gcctggaggg     3960

gaaggaggga ggcagtgaga gagatcgggg tggggggtgg ggggatgtcg ccagagctca     4020

ggggtgggga cagccttgtg cgcatcagtc ctgaggcctg gggcaccttt cgtctgatga     4080

gcctctgcat ggagagaggc tgagggctaa acacagctgg atgtcacctg agttcattta     4140

taggaagaga gaaatgtcga ggtgaaacgt aaaagcatct ggcaggaagg tgagtctgaa     4200

gccctgcacc cgcgttccga ctatcagtgg ggagctgtta gcacgtagga ttcttcagag     4260

cagctgggct ggagctcccc tgagctcagg aagccccagg gtgcaagggc aaggaaatga     4320

ggggtggtgg gtcagtgaag atctgggcag accttgtgtg gggaaggggt gctgctgtga     4380

cttcagggtc tgaggtccaa agacagcatt tgaaaagagg ctctgaagcc agtgtttgaa     4440

gaatttgttc ctgaagtacc tcctgggggt aggctagagg cttctggctt cagggtcctg     4500

aagaacacat tgaggtgccg tctgacactg gaatagggtg cccttcattc ctatgcctga     4560

gtccttaact atatttccaa cctccagtga ggaggagaag attcggaaat gtgacaggag     4620

agcaaacagg acagtttgca tgtgtgtgtg cgcacacata catgtgcgtg aaagattatc     4680

aataaaagtg cataaatttg ttgatctggt aagagtttct agcaggaagg tcgagccact     4740

tactgtaggt caagaagttg ctagttgcgg agttttttct tgcagttaga ctttacctag     4800

tggtagcagg gccaccaaag ctctgtgtcc cagatggtgt atggcccata atccacccaa     4860

cagcagcaaa ggaccaggca aaggagaaca ggagcagaag cctcccagcc actagccttt     4920

tgggctcagt ctctccaata atcctggaga ggggcttcgt tgggtctgga cacctaccat     4980

gcattctgtg acctttccct agcttccaat aaataactgt ttgacgccca gagtacagga     5040

taccacaatg cactcttcct gcgtagagca catgttccca tctgctccca ttcctcagga     5100

accttgaatt ctagctctgc tggcctttga gcccatgcca gtaaatgtcc tgatgggcat     5160

tgcctactat ctccagggca gctgcctttg tcctcctaac agctttattg gagtacagtt     5220

cacttaccat acaatccaca attgaccctg cacaatttga tgccggttta gtatagtcac     5280

agttcagcag ccatcagcac agtcagtctt agagtttact acccccaaaa gaaatccagc     5340

cccccttagt caccacccca acctccccat ccctaggcac ccctaggcta ctttgatctc     5400

tgtagacttg cctcttctgg acatgacata gagaaaggag tcataaattc tccaaggtgt     5460

ctgtttcttc tttaatgtca ttccctgttt ctcctcacat tccctcccca tttcctgggc     5520

ccagtctcac actggtcctt gcttacccta aatgctatta attccatcac tctgagtatg     5580

gtgtttgctg tccgctgaat gccaagagct tcaagagtgt gtgtaaataa agccacacct     5640

ttatttttgt attattctga accatggcta ataaattgtt tcaccaagaa atgtctctct     5700

aagaacaggt gccctccacg ctgtgcccct cccacctctt cagctcgtct cctgagtgtg     5760

cagaggtggt tccggttggg aaagaagcag cggagcatct aaccatgcct gtgtccaggc     5820

cgattatgca cgcagccacc aacaagctcc caactcccgc gtagagtttc atgacttttt     5880

cctgcctact atcttgatcc tagttttttt tttgtttttt ttttttttaa ggaataatta     5940

ctttgattca aaaccagttt ctcttttctg cataggaagg tccttgaagg tgtttagggt     6000

ctaaaaaggg tggtgttcgg tctctgaaac atccattcag cagtttgagc tgggatctct     6060

gaatgcaagg gtatgatgga tatacttctt tcttgctttt gttgtgtttt ggttttttgt     6120

ttgtttttaa gtcagggtct ctctgtcacc aggctgtatt acagtggtgc aatcatggct     6180

cactgcagcc tcgacctccc aggctcaagc catctttcca cctcagcctg ccagtggcta     6240

gaactacagg cgtgcaccac tgtgcccggc taatttgtgt gtatatattt tgtagaaatg     6300

gggtttcacc atgttgtcca ggctggtcac gaactcctgg gctcaagcca tctgcccgcc     6360

tcatcctccc aaagtgctgg gattataggc ctgagcccac cgtgcctggc ctttcctgtt     6420

tatctttgaa aattaaatag ggcataagag agaagaagat gtacttacaa tgcagtgggt     6480

ggttttaact ctatagcctt tgggctctgt ggttggtgct ccccttccta aataaatgag     6540

gtgtatgcag ggccctcttc tgccttagcg ccctgccagc tgggactcca gcaaggcccg     6600

gggcacctga ggacagagtg agatggaggg ccgctgctcc agcagccggg cctgcatccc     6660

acaagtcaac tgtgtcggac agaggatcct tacaaagaag aggcagcagg gttgggggct     6720

ggccagctgc tcgtccgccc taggtagctt gctcatctgt aaagtgggtg gggcaggagt     6780

tcccacctca tggggtcctg gcaagcctgc agtatccccg agtggcacca gcctgcttct     6840

ggggcagagc agtttgtgcc ccctgaggta ccactgatcc tctttccctg ctattaggta     6900

ttgctctctt cctccggtgt ttgccttttc agattataga agtaatatgt gttcccatat     6960

ttggcgtctc tcaggagctc aggaagtact tggctgagtg aacatgtcca ttgtggaaaa     7020

atggcaacaa tatggattcc atgggtatat tttatagaag aatatgaaga aaagcagcta     7080

cccctaaacc cattgcacaa gctgttcatg ttaattctgt acccgacgct ttccccacgg     7140

ggcctcccct cactctgaaa tggcatccag gtccatcttg ccctccacct ctgcatggct     7200

ctccatgccc catcgcctct cccagatcct agcactgggt ccacactctc gccctgtcca     7260

tttaggttga tgaaagcagg cagtcacccg ggtgggccag tcttgcctgt gggaggaaca     7320

tgcagtctcc tgtctcatgg tttgaagtgt gccaggaagc ctggcccagc ccacctcccc     7380

ctggagtcct tcccaggagg aataacccct taggtcattg actataagat gagttcgctc     7440

actggatcct tcctctctga tgagacagga agaaggtaca cagtgaccag gtaggaggag     7500

gagagggagt agaaaggagg gatgcgggtg gctggtccct gcatttgcct gcttccctgc     7560

acgggtgtcc cactggccgc ctctgctcac cagtgtcatg ggattctctc agaagatgaa     7620

aacagcccct gcttttttgc tagaatggct gagctttcat ggaaaggaag ctggacccaa     7680

gcaacagccg actaccgaag gttgcctgga gcagtgcaga tgtgggagga agaagggcct     7740

tggtgcacac tggcttttct tcctgactgc aatgtggcat tgtgccagct acctcctctt     7800

tctcggcctc aggaaaatgg agagaaagca gccctgaagg tggctgtgac gagggaaggg     7860

gcagagggcc tgacagtcaa ccacgcgcta tattttcctg ttcttcctta gggcaagaac     7920

tgcatggcca gactcaggca aggcctaggt gtgggctggg cattgcctac acgtgaagag     7980

atcactccgc gtccctactg cacctgtcac aaagtgcctt ctgatatgcc tggcaaacca     8040

aaatcggtga gcgccagctt gcttccctag aagacatttc taaatattca taacatgctt     8100

gctcaaatca atcaccttat tttacatccg ctccagggag aaatgaagac atggtcctac     8160

gttgttctgt aattattttc tatgtaaatt ttgttccttg ttacaattat atatgtctta     8220

ggggaaagga ccatttcaca tgtgtcacct catgtgattc tcaccacagc cctgtgattg     8280

ctcctgtttt ataaataatg acatagttcc agttgatggc caaagccaca gctaacgaga     8340

ggcagagaga gctcaggctc ccaggagctt ccactctcag accttgcctc ccgggctgcc     8400

ctgagtgaaa cgcctgctta gcatttggca cagccagaag cagcaagcta gggtcacaac     8460

acagagaggg gctgtgtaat actggctgcc tctgtgctaa gaaaaaaaaa aaatcactgt     8520

gtgtttgttt attttggtgc aggcccagtg ttcttgctta gacttaatac tacccttcat     8580

gttaaaataa aaccaaacaa aaacccat                                        8608


<210>  303

<400>  303
000

<210>  304
<211>  3634
<212>  DNA
<213>  Homo sapiens

<400>  304
gaattccggg tgatttcact cccggctgtc caggcttgtc ctgctacccc acccagcctt       60

tcctgaggcc tcaagcctgc caccaagccc ccagctcctt ctccccgcag gacccaaaca      120

caggcctcag gactcaacac agcttttccc tccaacccgt tttctctccc tcaacggact      180

cagctttctg aagcccctcc cagttctagt tctatctttt tcctgcatcc tgtctggaag      240

ttagaaggaa acagaccaca gacctggtcc ccaaaagaaa tggaggcaat aggttttgag      300

gggcatgggg acggggttca gcctccaggg tcctacacac aaatcagtca gtggcccaga      360

agacccccct cggaatcgga gcagggagga tggggagtgt gaggggtatc cttgatgctt      420

gtgtgtcccc aactttccaa atccccgccc ccgcgatgga gaagaaaccg agacagaagg      480

tgcagggccc actaccgctt cctccagatg agctcatggg tttctccacc aaggaagttt      540

tccgctggtt gaatgattct ttccccgccc tcctctcgcc ccagggacat ataaaggcag      600

ttgttggcac acccagccag cagacgctcc ctcagcaagg acagcagagg accagctaag      660

agggagagaa gcaactacag accccccctg aaaacaaccc tcagacgcca catcccctga      720

caagctgcca ggcaggttct cttcctctca catactgacc cacggcttca ccctctctcc      780

cctggaaagg acaccatgag cactgaaagc atgatccggg acgtggagct ggccgaggag      840

gcgctcccca agaagacagg ggggccccag ggctccaggc ggtgcttgtt cctcagcctc      900

ttctccttcc tgatcgtggc aggcgccacc acgctcttct gcctgctgca ctttggagtg      960

atcggccccc agagggaaga ggtgagtgcc tggccagcct tcatccactc tcccacccaa     1020

ggggaaatga gagacgcaag agagggagag agatgggatg ggtgaaagat gtgcgctgat     1080

agggagggat gagagagaaa aaaacatgga gaaagacggg gatgcagaaa gagatgtggc     1140

aagagatggg gaagagagag agagaaagat ggagagacag gatgtctggc acatggaagg     1200

tgctcactaa gtgtgtatgg agtgaatgaa tgaatgaatg aatgaacaag cagatatata     1260

aataagatat ggagacagat gtggggtgtg agaagagaga tgggggaaga aacaagtgat     1320

atgaataaag atggtgagac agaaagagcg ggaaatatga cagctaagga gagagatggg     1380

ggagataagg agagaagaag atagggtgtc tggcacacag aagacactca gggaaagagc     1440

tgttgaatgc tggaaggtga atacacagat gaatggagag agaaaaccag acacctcagg     1500

gctaagagcg caggccagac aggcagccag ctgttcctcc tttaagggtg actccctcga     1560

tgttaaccat tctccttctc cccaacagtt ccccagggac ctctctctaa tcagccctct     1620

ggcccaggca gtcagtaagt gtctccaaac ctctttccta attctgggtt tgggtttggg     1680

ggtagggtta gtaccggtat ggaagcagtg ggggaaattt aaagttttgg tcttggggga     1740

ggatggatgg aggtgaaagt aggggggtat tttctaggaa gtttaagggt ctcagctttt     1800

tcttttctct ctcctcttca ggatcatctt ctcgaacccc gagtgacaag cctgtagccc     1860

atgttgtagg taagagctct gaggatgtgt cttggaactt ggagggctag gatttgggga     1920

ttgaagcccg gctgatggta ggcagaactt ggagacaatg tgagaaggac tcgctgagct     1980

caagggaagg gtggaggaac agcacaggcc ttagtgggat actcagaacg tcatggccag     2040

gtgggatgtg ggatgacaga cagagaggac aggaaccgga tgtggggtgg gcagagctcg     2100

agggccagga tgtggagagt gaaccgacat ggccacactg actctcctct ccctctctcc     2160

ctccctccag caaaccctca agctgagggg cagctccagt ggctgaaccg ccgggccaat     2220

gccctcctgg ccaatggcgt ggagctgaga gataaccagc tggtggtgcc atcagagggc     2280

ctgtacctca tctactccca ggtcctcttc aagggccaag gctgcccctc cacccatgtg     2340

ctcctcaccc acaccatcag ccgcatcgcc gtctcctacc agaccaaggt caacctcctc     2400

tctgccatca agagcccctg ccagagggag accccagagg gggctgaggc caagccctgg     2460

tatgagccca tctatctggg aggggtcttc cagctggaga agggtgaccg actcagcgct     2520

gagatcaatc ggcccgacta tctcgacttt gccgagtctg ggcaggtcta ctttgggatc     2580

attgccctgt gaggaggacg aacatccaac cttcccaaac gcctcccctg ccccaatccc     2640

tttattaccc cctccttcag acaccctcaa cctcttctgg ctcaaaaaga gaattggggg     2700

cttagggtcg gaacccaagc ttagaacttt aagcaacaag accaccactt cgaaacctgg     2760

gattcaggaa tgtgtggcct gcacagtgaa gtgctggcaa ccactaagaa ttcaaactgg     2820

ggcctccaga actcactggg gcctacagct ttgatccctg acatctggaa tctggagacc     2880

agggagcctt tggttctggc cagaatgctg caggacttga gaagacctca cctagaaatt     2940

gacacaagtg gaccttaggc cttcctctct ccagatgttt ccagacttcc ttgagacacg     3000

gagcccagcc ctccccatgg agccagctcc ctctatttat gtttgcactt gtgattattt     3060

attatttatt tattatttat ttatttacag atgaatgtat ttatttggga gaccggggta     3120

tcctggggga cccaatgtag gagctgcctt ggctcagaca tgttttccgt gaaaacggag     3180

ctgaacaata ggctgttccc atgtagcccc ctggcctctg tgccttcttt tgattatgtt     3240

ttttaaaata tttatctgat taagttgtct aaacaatgct gatttggtga ccaactgtca     3300

ctcattgctg agcctctgct ccccagggga gttgtgtctg taatcgccct actattcagt     3360

ggcgagaaat aaagtttgct tagaaaagaa acatggtctc cttcttggaa ttaattctgc     3420

atctgcctct tcttgtgggt gggaagaagc tccctaagtc ctctctccac aggctttaag     3480

atccctcgga cccagtccca tccttagact cctagggccc tggagaccct acataaacaa     3540

agcccaacag aatattcccc atcccccagg aaacaagagc ctgaacctaa ttacctctcc     3600

ctcagggcat gggaatttcc aactctggga attc                                 3634


<210>  305
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  306
<211>  3710
<212>  DNA
<213>  Homo sapiens

<400>  306
gggtctccgc gcccaggaaa gccccgcgcg gcgcgggcca gggaagggcc acccaggggt       60

cccccacttc ccgcttgggc gcccggacgg cgaatggagc aggggcgcgc agataattaa      120

agatttacac acagctggaa gaaatcatag agaagccggg cgtggtggct catgcctata      180

atcccagcac ttttggaggc tgaggcgggc agatcacttg agatcaggag ttcgagacca      240

gcctggtgcc ttggcatctc ccaatggggt ggctttgctc tgggctcctg ttccctgtga      300

gctgcctggt cctgctgcag gtggcaagct ctgggaacat gaaggtcttg caggagccca      360

cctgcgtctc cgactacatg agcatctcta cttgcgagtg gaagatgaat ggtcccacca      420

attgcagcac cgagctccgc ctgttgtacc agctggtttt tctgctctcc gaagcccaca      480

cgtgtatccc tgagaacaac ggaggcgcgg ggtgcgtgtg ccacctgctc atggatgacg      540

tggtcagtgc ggataactat acactggacc tgtgggctgg gcagcagctg ctgtggaagg      600

gctccttcaa gcccagcgag catgtgaaac ccagggcccc aggaaacctg acagttcaca      660

ccaatgtctc cgacactctg ctgctgacct ggagcaaccc gtatccccct gacaattacc      720

tgtataatca tctcacctat gcagtcaaca tttggagtga aaacgacccg gcagatttca      780

gaatctataa cgtgacctac ctagaaccct ccctccgcat cgcagccagc accctgaagt      840

ctgggatttc ctacagggca cgggtgaggg cctgggctca gtgctataac accacctgga      900

gtgagtggag ccccagcacc aagtggcaca actcctacag ggagcccttc gagcagcacc      960

tcctgctggg cgtcagcgtt tcctgcattg tcatcctggc cgtctgcctg ttgtgctatg     1020

tcagcatcac caagattaag aaagaatggt gggatcagat tcccaaccca gcccgcagcc     1080

gcctcgtggc tataataatc caggatgctc aggggtcaca gtgggagaag cggtcccgag     1140

gccaggaacc agccaagtgc ccacactgga agaattgtct taccaagctc ttgccctgtt     1200

ttctggagca caacatgaaa agggatgaag atcctcacaa ggctgccaaa gagatgcctt     1260

tccagggctc tggaaaatca gcatggtgcc cagtggagat cagcaagaca gtcctctggc     1320

cagagagcat cagcgtggtg cgatgtgtgg agttgtttga ggccccggtg gagtgtgagg     1380

aggaggagga ggtagaggaa gaaaaaggga gcttctgtgc atcgcctgag agcagcaggg     1440

atgacttcca ggagggaagg gagggcattg tggcccggct aacagagagc ctgttcctgg     1500

acctgctcgg agaggagaat gggggctttt gccagcagga catgggggag tcatgccttc     1560

ttccaccttc gggaagtacg agtgctcaca tgccctggga tgagttccca agtgcagggc     1620

ccaaggaggc acctccctgg ggcaaggagc agcctctcca cctggagcca agtcctcctg     1680

ccagcccgac ccagagtcca gacaacctga cttgcacaga gacgcccctc gtcatcgcag     1740

gcaaccctgc ttaccgcagc ttcagcaact ccctgagcca gtcaccgtgt cccagagagc     1800

tgggtccaga cccactgctg gccagacacc tggaggaagt agaacccgag atgccctgtg     1860

tcccccagct ctctgagcca accactgtgc cccaacctga gccagaaacc tgggagcaga     1920

tcctccgccg aaatgtcctc cagcatgggg cagctgcagc ccccgtctcg gcccccacca     1980

gtggctatca ggagtttgta catgcggtgg agcagggtgg cacccaggcc agtgcggtgg     2040

tgggcttggg tcccccagga gaggctggtt acaaggcctt ctcaagcctg cttgccagca     2100

gtgctgtgtc cccagagaaa tgtgggtttg gggctagcag tggggaagag gggtataagc     2160

ctttccaaga cctcattcct ggctgccctg gggaccctgc cccagtccct gtccccttgt     2220

tcacctttgg actggacagg gagccacctc gcagtccgca gagctcacat ctcccaagca     2280

gctccccaga gcacctgggt ctggagccgg gggaaaaggt agaggacatg ccaaagcccc     2340

cacttcccca ggagcaggcc acagaccccc ttgtggacag cctgggcagt ggcattgtct     2400

actcagccct tacctgccac ctgtgcggcc acctgaaaca gtgtcatggc caggaggatg     2460

gtggccagac ccctgtcatg gccagtcctt gctgtggctg ctgctgtgga gacaggtcct     2520

cgccccctac aacccccctg agggccccag acccctctcc aggtggggtt ccactggagg     2580

ccagtctgtg tccggcctcc ctggcaccct cgggcatctc agagaagagt aaatcctcat     2640

catccttcca tcctgcccct ggcaatgctc agagctcaag ccagaccccc aaaatcgtga     2700

actttgtctc cgtgggaccc acatacatga gggtctctta ggtgcatgtc ctcttgttgc     2760

tgagtctgca gatgaggact agggcttatc catgcctggg aaatgccacc tcctggaagg     2820

cagccaggct ggcagatttc caaaagactt gaagaaccat ggtatgaagg tgattggccc     2880

cactgacgtt ggcctaacac tgggctgcag agactggacc ccgcccagca ttgggctggg     2940

ctcgccacat cccatgagag tagagggcac tgggtcgccg tgccccacgg caggcccctg     3000

caggaaaact gaggcccttg ggcacctcga cttgtgaacg agttgttggc tgctccctcc     3060

acagcttctg cagcagactg tccctgttgt aactgcccaa ggcatgtttt gcccaccaga     3120

tcatggccca cgtggaggcc cacctgcctc tgtctcactg aactagaagc cgagcctaga     3180

aactaacaca gccatcaagg gaatgacttg ggcggccttg ggaaatcgat gagaaattga     3240

acttcaggga gggtggtcat tgcctagagg tgctcattca tttaacagag cttccttagg     3300

ttgatgctgg aggcagaatc ccggctgtca aggggtgttc agttaagggg agcaacagag     3360

gacatgaaaa attgctatga ctaaagcagg gacaatttgc tgccaaacac ccatgcccag     3420

ctgtatggct gggggctcct cgtatgcatg gaacccccag aataaatatg ctcagccacc     3480

ctgtgggccg ggcaatccag acagcaggca taaggcacca gttaccctgc atgttggccc     3540

agacctcagg tgctagggaa ggcgggaacc ttgggttgag taatgctcgt ctgtgtgttt     3600

tagtttcatc acctgttatc tgtgtttgct gaggagagtg gaacagaagg ggtggagttt     3660

tgtataaata aagtttcttt gtctctttaa aaaaaaaaaa aaaaaaaaaa                3710


<210>  307
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  307
accaaacctc ttcgaggcac aaggcacaac aggctgctct gggattctct tcagccaatc       60

ttcattgctc aagtgtctga agcagccatg gcagaagtac ctgagctcgc cagtgaaatg      120

atggcttatt acagtggcaa tgaggatgac ttgttctttg aagctgatgg ccctaaacag      180

atgaagtgct ccttccagga cctggacctc tgccctctgg atggcggcat ccagctacga      240

atctccgacc accactacag caagggcttc aggcaggccg cgtcagttgt tgtggccatg      300

gacaagctga ggaagatgct ggttccctgc ccacagacct tccaggagaa tgacctgagc      360

accttctttc ccttcatctt tgaagaagaa cctatcttct tcgacacatg ggataacgag      420

gcttatgtgc acgatgcacc tgtacgatca ctgaactgca cgctccggga ctcacagcaa      480

aaaagcttgg tgatgtctgg tccatatgaa ctgaaagctc tccacctcca gggacaggat      540

atggagcaac aagtggtgtt ctccatgtcc tttgtacaag gagaagaaag taatgacaaa      600

atacctgtgg ccttgggcct caaggaaaag aatctgtacc tgtcctgcgt gttgaaagat      660

gataagccca ctctacagct ggagagtgta gatcccaaaa attacccaaa gaagaagatg      720

gaaaagcgat ttgtcttcaa caagatagaa atcaataaca agctggaatt tgagtctgcc      780

cagttcccca actggtacat cagcacctct caagcagaaa acatgcccgt cttcctggga      840

gggaccaaag gcggccagga tataactgac ttcaccatgc aatttgtgtc ttcctaaaga      900

gagctgtacc cagagagtcc tgtgctgaat gtggactcaa tccctagggc tggcagaaag      960

ggaacagaaa ggtttttgag tacggctata gcctggactt tcctgttgtc tacaccaatg     1020

cccaactgcc tgccttaggg tagtgctaag aggatctcct gtccatcagc caggacagtc     1080

agctctctcc tttcagggcc aatccccagc ccttttgttg agccaggcct ctctcacctc     1140

tcctactcac ttaaagcccg cctgacagaa accacggcca catttggttc taagaaaccc     1200

tctgtcattc gctcccacat tctgatgagc aaccgcttcc ctatttattt atttatttgt     1260

ttgtttgttt tattcattgg tctaatttat tcaaaggggg caagaagtag cagtgtctgt     1320

aaaagagcct agtttttaat agctatggaa tcaattcaat ttggactggt gtgctctctt     1380

taaatcaagt cctttaatta agactgaaaa tatataagct cagattattt aaatgggaat     1440

atttataaat gagcaaatat catactgttc aatggttctg aaataaactt cactgaag       1498


<210>  308
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  308
aaactcacac aacaactctt ccccgctgag aggagacagc cagtgcgact ccaccctcca       60

gctcgacggc agccgccccg gccgacagcc ccgagacgac agcccggcgc gtcccggtcc      120

ccacctccga ccaccgccag cgctccaggc cccgccgctc cccgctcgcc gccaccgcgc      180

cctccgctcc gcccgcagtg ccaaccatga ccgccgccag tatgggcccc gtccgcgtcg      240

ccttcgtggt cctcctcgcc ctctgcagcc ggccggccgt cggccagaac tgcagcgggc      300

cgtgccggtg cccggacgag ccggcgccgc gctgcccggc gggcgtgagc ctcgtgctgg      360

acggctgcgg ctgctgccgc gtctgcgcca agcagctggg cgagctgtgc accgagcgcg      420

acccctgcga cccgcacaag ggcctcttct gtgacttcgg ctccccggcc aaccgcaaga      480

tcggcgtgtg caccgccaaa gatggtgctc cctgcatctt cggtggtacg gtgtaccgca      540

gcggagagtc cttccagagc agctgcaagt accagtgcac gtgcctggac ggggcggtgg      600

gctgcatgcc cctgtgcagc atggacgttc gtctgcccag ccctgactgc cccttcccga      660

ggagggtcaa gctgcccggg aaatgctgcg aggagtgggt gtgtgacgag cccaaggacc      720

aaaccgtggt tgggcctgcc ctcgcggctt accgactgga agacacgttt ggcccagacc      780

caactatgat tagagccaac tgcctggtcc agaccacaga gtggagcgcc tgttccaaga      840

cctgtgggat gggcatctcc acccgggtta ccaatgacaa cgcctcctgc aggctagaga      900

agcagagccg cctgtgcatg gtcaggcctt gcgaagctga cctggaagag aacattaaga      960

agggcaaaaa gtgcatccgt actcccaaaa tctccaagcc tatcaagttt gagctttctg     1020

gctgcaccag catgaagaca taccgagcta aattctgtgg agtatgtacc gacggccgat     1080

gctgcacccc ccacagaacc accaccctgc cggtggagtt caagtgccct gacggcgagg     1140

tcatgaagaa gaacatgatg ttcatcaaga cctgtgcctg ccattacaac tgtcccggag     1200

acaatgacat ctttgaatcg ctgtactaca ggaagatgta cggagacatg gcatgaagcc     1260

agagagtgag agacattaac tcattagact ggaacttgaa ctgattcaca tctcattttt     1320

ccgtaaaaat gatttcagta gcacaagtta tttaaatctg tttttctaac tgggggaaaa     1380

gattcccacc caattcaaaa cattgtgcca tgtcaaacaa atagtctatc aaccccagac     1440

actggtttga agaatgttaa gacttgacag tggaactaca ttagtacaca gcaccagaat     1500

gtatattaag gtgtggcttt aggagcagtg ggagggtacc agcagaaagg ttagtatcat     1560

cagatagcat cttatacgag taatatgcct gctatttgaa gtgtaattga gaaggaaaat     1620

tttagcgtgc tcactgacct gcctgtagcc ccagtgacag ctaggatgtg cattctccag     1680

ccatcaagag actgagtcaa gttgttcctt aagtcagaac agcagactca gctctgacat     1740

tctgattcga atgacactgt tcaggaatcg gaatcctgtc gattagactg gacagcttgt     1800

ggcaagtgaa tttgcctgta acaagccaga ttttttaaaa tttatattgt aaatattgtg     1860

tgtgtgtgtg tgtgtgtata tatatatata tgtacagtta tctaagttaa tttaaagttg     1920

tttgtgcctt tttatttttg tttttaatgc tttgatattt caatgttagc ctcaatttct     1980

gaacaccata ggtagaatgt aaagcttgtc tgatcgttca aagcatgaaa tggatactta     2040

tatggaaatt ctgctcagat agaatgacag tccgtcaaaa cagattgttt gcaaagggga     2100

ggcatcagtg tccttggcag gctgatttct aggtaggaaa tgtggtagcc tcacttttaa     2160

tgaacaaatg gcctttatta aaaactgagt gactctatat agctgatcag ttttttcacc     2220

tggaagcatt tgtttctact ttgatatgac tgtttttcgg acagtttatt tgttgagagt     2280

gtgaccaaaa gttacatgtt tgcacctttc tagttgaaaa taaagtgtat attttttcta     2340

taaaaaaaaa aaaaaaaa                                                   2358


<210>  309
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  309

Met Gly Trp Leu Cys Ser Gly Leu Leu Phe Pro Val Ser Cys Leu Val 
1               5                   10                  15      


Leu Leu Gln Val Ala Ser Ser Gly Asn Met Lys Val Leu Gln Glu Pro 
            20                  25                  30          


Thr Cys Val Ser Asp Tyr Met Ser Ile Ser Thr Cys Glu Trp Lys Met 
        35                  40                  45              


Asn Gly Pro Thr Asn Cys Ser Thr Glu Leu Arg Leu Leu Tyr Gln Leu 
    50                  55                  60                  


Val Phe Leu Leu Ser Glu Ala His Thr Cys Ile Pro Glu Asn Asn Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Val Cys His Leu Leu Met Asp Asp Val Val Ser Ala 
                85                  90                  95      


Asp Asn Tyr Thr Leu Asp Leu Trp Ala Gly Gln Gln Leu Leu Trp Lys 
            100                 105                 110         


Gly Ser Phe Lys Pro Ser Glu His Val Lys Pro Arg Ala Pro Gly Asn 
        115                 120                 125             


Leu Thr Val His Thr Asn Val Ser Asp Thr Leu Leu Leu Thr Trp Ser 
    130                 135                 140                 


Asn Pro Tyr Pro Pro Asp Asn Tyr Leu Tyr Asn His Leu Thr Tyr Ala 
145                 150                 155                 160 


Val Asn Ile Trp Ser Glu Asn Asp Pro Ala Asp Phe Arg Ile Tyr Asn 
                165                 170                 175     


Val Thr Tyr Leu Glu Pro Ser Leu Arg Ile Ala Ala Ser Thr Leu Lys 
            180                 185                 190         


Ser Gly Ile Ser Tyr Arg Ala Arg Val Arg Ala Trp Ala Gln Cys Tyr 
        195                 200                 205             


Asn Thr Thr Trp Ser Glu Trp Ser Pro Ser Thr Lys Trp His Asn Ser 
    210                 215                 220                 


Tyr Arg Glu Pro Phe Glu Gln His Leu Leu Leu Gly Val Ser Val Ser 
225                 230                 235                 240 


Cys Ile Val Ile Leu Ala Val Cys Leu Leu Cys Tyr Val Ser Ile Thr 
                245                 250                 255     


Lys Ile Lys Lys Glu Trp Trp Asp Gln Ile Pro Asn Pro Ala Arg Ser 
            260                 265                 270         


Arg Leu Val Ala Ile Ile Ile Gln Asp Ala Gln Gly Ser Gln Trp Glu 
        275                 280                 285             


Lys Arg Ser Arg Gly Gln Glu Pro Ala Lys Cys Pro His Trp Lys Asn 
    290                 295                 300                 


Cys Leu Thr Lys Leu Leu Pro Cys Phe Leu Glu His Asn Met Lys Arg 
305                 310                 315                 320 


Asp Glu Asp Pro His Lys Ala Ala Lys Glu Met Pro Phe Gln Gly Ser 
                325                 330                 335     


Gly Lys Ser Ala Trp Cys Pro Val Glu Ile Ser Lys Thr Val Leu Trp 
            340                 345                 350         


Pro Glu Ser Ile Ser Val Val Arg Cys Val Glu Leu Phe Glu Ala Pro 
        355                 360                 365             


Val Glu Cys Glu Glu Glu Glu Glu Val Glu Glu Glu Lys Gly Ser Phe 
    370                 375                 380                 


Cys Ala Ser Pro Glu Ser Ser Arg Asp Asp Phe Gln Glu Gly Arg Glu 
385                 390                 395                 400 


Gly Ile Val Ala Arg Leu Thr Glu Ser Leu Phe Leu Asp Leu Leu Gly 
                405                 410                 415     


Glu Glu Asn Gly Gly Phe Cys Gln Gln Asp Met Gly Glu Ser Cys Leu 
            420                 425                 430         


Leu Pro Pro Ser Gly Ser Thr Ser Ala His Met Pro Trp Asp Glu Phe 
        435                 440                 445             


Pro Ser Ala Gly Pro Lys Glu Ala Pro Pro Trp Gly Lys Glu Gln Pro 
    450                 455                 460                 


Leu His Leu Glu Pro Ser Pro Pro Ala Ser Pro Thr Gln Ser Pro Asp 
465                 470                 475                 480 


Asn Leu Thr Cys Thr Glu Thr Pro Leu Val Ile Ala Gly Asn Pro Ala 
                485                 490                 495     


Tyr Arg Ser Phe Ser Asn Ser Leu Ser Gln Ser Pro Cys Pro Arg Glu 
            500                 505                 510         


Leu Gly Pro Asp Pro Leu Leu Ala Arg His Leu Glu Glu Val Glu Pro 
        515                 520                 525             


Glu Met Pro Cys Val Pro Gln Leu Ser Glu Pro Thr Thr Val Pro Gln 
    530                 535                 540                 


Pro Glu Pro Glu Thr Trp Glu Gln Ile Leu Arg Arg Asn Val Leu Gln 
545                 550                 555                 560 


His Gly Ala Ala Ala Ala Pro Val Ser Ala Pro Thr Ser Gly Tyr Gln 
                565                 570                 575     


Glu Phe Val His Ala Val Glu Gln Gly Gly Thr Gln Ala Ser Ala Val 
            580                 585                 590         


Val Gly Leu Gly Pro Pro Gly Glu Ala Gly Tyr Lys Ala Phe Ser Ser 
        595                 600                 605             


Leu Leu Ala Ser Ser Ala Val Ser Pro Glu Lys Cys Gly Phe Gly Ala 
    610                 615                 620                 


Ser Ser Gly Glu Glu Gly Tyr Lys Pro Phe Gln Asp Leu Ile Pro Gly 
625                 630                 635                 640 


Cys Pro Gly Asp Pro Ala Pro Val Pro Val Pro Leu Phe Thr Phe Gly 
                645                 650                 655     


Leu Asp Arg Glu Pro Pro Arg Ser Pro Gln Ser Ser His Leu Pro Ser 
            660                 665                 670         


Ser Ser Pro Glu His Leu Gly Leu Glu Pro Gly Glu Lys Val Glu Asp 
        675                 680                 685             


Met Pro Lys Pro Pro Leu Pro Gln Glu Gln Ala Thr Asp Pro Leu Val 
    690                 695                 700                 


Asp Ser Leu Gly Ser Gly Ile Val Tyr Ser Ala Leu Thr Cys His Leu 
705                 710                 715                 720 


Cys Gly His Leu Lys Gln Cys His Gly Gln Glu Asp Gly Gly Gln Thr 
                725                 730                 735     


Pro Val Met Ala Ser Pro Cys Cys Gly Cys Cys Cys Gly Asp Arg Ser 
            740                 745                 750         


Ser Pro Pro Thr Thr Pro Leu Arg Ala Pro Asp Pro Ser Pro Gly Gly 
        755                 760                 765             


Val Pro Leu Glu Ala Ser Leu Cys Pro Ala Ser Leu Ala Pro Ser Gly 
    770                 775                 780                 


Ile Ser Glu Lys Ser Lys Ser Ser Ser Ser Phe His Pro Ala Pro Gly 
785                 790                 795                 800 


Asn Ala Gln Ser Ser Ser Gln Thr Pro Lys Ile Val Asn Phe Val Ser 
                805                 810                 815     


Val Gly Pro Thr Tyr Met Arg Val Ser 
            820                 825 


<210>  310
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  310

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  311
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  311

Met Thr Ala Ala Ser Met Gly Pro Val Arg Val Ala Phe Val Val Leu 
1               5                   10                  15      


Leu Ala Leu Cys Ser Arg Pro Ala Val Gly Gln Asn Cys Ser Gly Pro 
            20                  25                  30          


Cys Arg Cys Pro Asp Glu Pro Ala Pro Arg Cys Pro Ala Gly Val Ser 
        35                  40                  45              


Leu Val Leu Asp Gly Cys Gly Cys Cys Arg Val Cys Ala Lys Gln Leu 
    50                  55                  60                  


Gly Glu Leu Cys Thr Glu Arg Asp Pro Cys Asp Pro His Lys Gly Leu 
65                  70                  75                  80  


Phe Cys His Phe Gly Ser Pro Ala Asn Arg Lys Ile Gly Val Cys Thr 
                85                  90                  95      


Ala Lys Asp Gly Ala Pro Cys Ile Phe Gly Gly Thr Val Tyr Arg Ser 
            100                 105                 110         


Gly Glu Ser Phe Gln Ser Ser Cys Lys Tyr Gln Cys Thr Cys Leu Asp 
        115                 120                 125             


Gly Ala Val Gly Cys Met Pro Leu Cys Ser Met Asp Val Arg Leu Pro 
    130                 135                 140                 


Ser Pro Asp Cys Pro Phe Pro Arg Arg Val Lys Leu Pro Gly Lys Cys 
145                 150                 155                 160 


Cys Glu Glu Trp Val Cys Asp Glu Pro Lys Asp Gln Thr Val Val Gly 
                165                 170                 175     


Pro Ala Leu Ala Ala Tyr Arg Leu Glu Asp Thr Phe Gly Pro Asp Pro 
            180                 185                 190         


Thr Met Ile Arg Ala Asn Cys Leu Val Gln Thr Thr Glu Trp Ser Ala 
        195                 200                 205             


Cys Ser Lys Thr Cys Gly Met Gly Ile Ser Thr Arg Val Thr Asn Asp 
    210                 215                 220                 


Asn Ala Ser Cys Arg Leu Glu Lys Gln Ser Arg Leu Cys Met Val Arg 
225                 230                 235                 240 


Pro Cys Glu Ala Asp Leu Glu Glu Asn Ile Lys Lys Gly Lys Lys Cys 
                245                 250                 255     


Ile Arg Thr Pro Lys Ile Ser Lys Pro Ile Lys Phe Glu Leu Ser Gly 
            260                 265                 270         


Cys Thr Ser Met Lys Thr Tyr Arg Ala Lys Phe Cys Gly Val Cys Thr 
        275                 280                 285             


Asp Gly Arg Cys Cys Thr Pro His Arg Thr Thr Thr Leu Pro Val Glu 
    290                 295                 300                 


Phe Lys Cys Pro Asp Gly Glu Val Met Lys Lys Asn Met Met Phe Ile 
305                 310                 315                 320 


Lys Thr Cys Ala Cys His Tyr Asn Cys Pro Gly Asp Asn Asp Ile Phe 
                325                 330                 335     


Glu Ser Leu Tyr Tyr Arg Lys Met Tyr Gly Asp Met Ala 
            340                 345                 

             
