                         SEQUENCE LISTING

<110>  Weiner, David
       Patel, Ami
       Yan, Jian
 
<120>  DNA ANTIBODY CONSTRUCTS FOR USE AGAINST PSEUDOMONAS AERUGINOSA

<130>  206108-0058-00-WO.606335

<150>  US 62/332,363
<151>  2016-05-05

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9308: V2L2MD heavy chain

<400>  1
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ctggcggcag cctgaggctg       60

tcctgcgcag catctggctt cacctttagc tcctatgcaa tgaactgggt gcgccaggca      120

ccaggcaagg gactggagtg ggtgtctgcc atcacaatga gcggcatcac cgcctactat      180

acagacgatg tgaagggcag gtttaccatc agcagagaca actccaagaa tacactgtac      240

ctgcagatga atagcctgag agccgaggat accgccgtgt actattgcgc caaggaggag      300

ttcctgcccg gcacacacta ctattacgga atggacgtgt ggggacaggg aaccacagtg      360

accgtgtcta gcgcctccac aaagggacct agcgtgttcc cactggcacc ctcctctaag      420

tccacctctg gcggcacagc cgccctgggc tgtctggtga aggattattt cccagagccc      480

gtgaccgtgt cttggaacag cggcgccctg acctctggag tgcacacatt tccagccgtg      540

ctgcagagct ccggcctgta tagcctgtct agcgtggtga ccgtgccctc ctctagcctg      600

ggcacccaga catacatctg caacgtgaat cacaagccat ctaatacaaa ggtggacaag      660

aaggtggagc ccaagagctg tgataagacc cacacatgcc ctccctgtcc tgcaccagag      720

ctgctgggcg gcccatccgt gttcctgttt ccacccaagc ctaaggacac cctgatgatc      780

tcccggaccc cagaggtgac atgcgtggtg gtggacgtgt ctcacgagga ccccgaggtg      840

aagttcaact ggtacgtgga tggcgtggag gtgcacaatg ccaagaccaa gccacgggag      900

gagcagtata acagcaccta ccgcgtggtg tccgtgctga cagtgctgca ccaggactgg      960

ctgaacggca aggagtacaa gtgcaaggtg agcaataagg ccctgcccgc ccctatcgag     1020

aagaccatct ccaaggccaa gggccagcct agggagccac aggtgtatac actgcctcca     1080

agcagagacg agctgaccaa gaaccaggtg tccctgacat gtctggtgaa gggcttctac     1140

ccttccgata tcgccgtgga gtgggagtct aatggccagc cagagaacaa ttataagacc     1200

acaccccctg tgctggactc cgatggctct ttctttctgt actctaagct gaccgtggat     1260

aagagccgct ggcagcaggg caacgtgttt agctgttccg tgatgcacga ggccctgcac     1320

aatcactaca cacagaagtc tctgagcctg tcccctggca ag                        1362


<210>  2
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9308: V2L2MD heavy chain

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  3
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9309: V2L2MD light chain

<400>  3
gcaatccaga tgacccagtc cccaagctcc ctgagcgcct ccgtgggcga cagggtgacc       60

atcacatgca gagcctctca gggcatccgg aacgatctgg gctggtacca gcagaagcca      120

ggcaaggccc ccaagctgct gatctattct gccagcaccc tgcagtctgg agtgcccagc      180

cggttctccg gctctggcag cggaacagac tttaccctga caatctctag cctgcagcct      240

gaggacttcg ccacctacta ttgcctgcag gattacaatt atccatggac ctttggccag      300

ggcacaaagg tggagatcaa gcgcacagtg gccgccccca gcgtgttcat ctttccccct      360

agcgacgagc agctgaagtc cggcaccgcc tctgtggtgt gcctgctgaa caatttctac      420

cctagggagg ccaaggtgca gtggaaggtg gataacgccc tgcagagcgg caattcccag      480

gagtctgtga ccgagcagga cagcaaggat tccacatatt ccctgtctaa caccctgaca      540

ctgagcaagg ccgattacga gaagcacaag gtgtatgcat gcgaggtgac ccaccaggga      600

ctgtcctctc ccgtgacaaa gtcctttaat aggggcgagt gt                         642


<210>  4
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9309: V2L2MD light chain

<400>  4

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9214: Pseudo-V2L2MD; DMAb-antiPcrV

<400>  5
gaggtgcagc tgctggagtc aggaggagga ctggtgcagc ccggcggatc actgcgactg       60

agctgcgcag cttccggctt caccttcagc agctatgcca tgaactgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgagtgca atcaccatgt cagggattac tgcctactat      180

accgacgatg tgaaaggccg attcactatc tctagggaca acagtaagaa taccctgtac      240

ctgcagatga attccctgcg cgctgaggat acagcagtgt actattgcgc caaggaggaa      300

ttcctgccag ggactcacta ctattacgga atggacgtgt ggggacaggg aaccacagtc      360

accgtgtcta gtgcaagcac aaaaggcccc tccgtgtttc ccctggcccc ttcaagcaag      420

tctacaagtg ggggcactgc agccctggga tgtctggtga aggattactt ccctgagcca      480

gtcaccgtga gctggaactc cggcgccctg acttccggag tccatacctt tcctgctgtg      540

ctgcagtcct ctggcctgta tagcctgagt tcagtggtca ccgtcccaag ctcctctctg      600

ggaacacaga cttacatctg caacgtgaat cacaaaccaa gcaatacaaa ggtcgacaag      660

aaagtggaac ccaaatcctg tgataagacc catacatgcc ctccctgtcc agcacctgag      720

ctgctgggag ggccaagcgt gttcctgttt ccacccaagc ctaaagacac actgatgatt      780

tctcggaccc ccgaagtcac atgcgtggtc gtggacgtga gccacgagga ccccgaagtc      840

aagtttaact ggtacgtgga tggcgtcgag gtgcataatg ccaagaccaa accacgagag      900

gaacagtata actctacata cagggtcgtg agtgtcctga ctgtgctgca ccaggactgg      960

ctgaacggga aggagtacaa gtgcaaagtg tccaacaagg ccctgccagc tcccatcgag     1020

aagaccattt ctaaggccaa aggccagcca agagaacccc aggtgtatac actgcctcca     1080

agtcgggacg agctgactaa aaaccaggtc tctctgacct gtctggtgaa gggattctac     1140

ccttccgata tcgctgtgga gtgggaatct aatgggcagc cagaaaacaa ttataagact     1200

acccctcccg tgctggactc tgatggaagt ttctttctgt actccaaact gaccgtggac     1260

aagtctagat ggcagcaggg gaacgtcttt tcatgcagcg tgatgcatga ggccctgcac     1320

aatcattaca ctcagaaatc cctgtctctg agtcctggga aacggggccg caagaggaga     1380

tcaggaagcg gggccaccaa cttctccctg ctgaagcagg ctggcgatgt ggaggaaaat     1440

cctggaccaa tggtcctgca gactcaggtg tttatctcac tgctgctgtg gattagcgga     1500

gcatacgggg ccattcagat gacccagtcc cccagttcac tgtccgcttc tgtcggcgac     1560

agagtgacta tcacctgtcg ggcaagccag ggaattcgca acgatctggg gtggtatcag     1620

cagaagcctg ggaaagctcc aaagctgctg atctacagtg catcaactct gcagtcagga     1680

gtgcctagcc ggttcagcgg ctccggatct ggaaccgact ttacactgac tattagctcc     1740

ctgcagccag aggacttcgc cacatattac tgcctgcagg attataatta cccctggaca     1800

tttggccagg gaactaaagt ggaaatcaag cgcacagtcg ctgcacctag cgtgttcatc     1860

tttccaccct cagacgagca gctgaagtcc ggaactgctt ctgtggtgtg cctgctgaac     1920

aatttctatc caagggaagc aaaagtccag tggaaggtgg ataacgccct gcagtcaggc     1980

aatagccagg agtccgtgac cgaacaggac tctaaagata gtacatacag tctgtcaaac     2040

accctgacac tgagcaaggc tgattatgag aagcacaaag tgtacgcatg cgaagtcacc     2100

caccaggggc tgtcctcacc agtcacaaaa tctttcaatc ggggagaatg c              2151


<210>  6
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9214: Pseudo-V2L2MD; DMAb-antiPcrV

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly 
    450                 455                 460                 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
465                 470                 475                 480 


Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu 
                485                 490                 495     


Trp Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser 
            500                 505                 510         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        515                 520                 525             


Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly 
    530                 535                 540                 


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly 
545                 550                 555                 560 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                565                 570                 575     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
            580                 585                 590         


Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
        595                 600                 605             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    610                 615                 620                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
625                 630                 635                 640 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                645                 650                 655     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            660                 665                 670         


Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp 
        675                 680                 685             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    690                 695                 700                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
705                 710                 715         


<210>  7
<211>  2154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9247: V2L2 with Rhesus Fc in pGX0001; 
       DMAb-antiPcrV

<400>  7
gaggtgcagc tcctggaaag tgggggaggg ctggtgcagc ccggcgggtc cctcagactg       60

tcttgcgccg ctagtggctt cacctttagc tcctatgcaa tgaactgggt gcggcaggca      120

cctgggaaag gactggagtg ggtgagcgcc atcaccatgt ccggcattac tgcatactat      180

accgacgatg tgaaagggag gttcacaatc tcaagagaca acagcaagaa tactctctac      240

ctgcagatga atagcctgcg cgctgaggat actgcagtgt actattgcgc caaggaggaa      300

ttcctgccag gcacccacta ctattacgga atggacgtgt ggggacaggg aaccacagtc      360

accgtgtcta gtgcttctac aaaagggccc agcgtgttcc cactggcacc ctcaagcagg      420

agtacatcag agagcactgc agccctcgga tgtctggtga aggattactt ccccgaacct      480

gtcaccgtgt cctggaactc cggatctctc acttctggcg tccacacctt tcccgccgtg      540

ctgcagtcct ctgggctcta tagcctgagt tcagtggtca ccgtgcctag ctcctctctg      600

ggaacacaga cttacgtctg caacgtgaat cataagccat ccaatacaaa ggtcgacaaa      660

agagtggaga tcaaaacctg tggaggcggg tctaagcccc ctacatgccc accctgtcca      720

gcaccagaac tgctcggagg cccaagcgtg ttcctctttc ctccaaagcc caaagacacc      780

ctgatgattt cccggacccc agaggtcaca tgcgtggtcg tggacgtgag ccaggaagac      840

cctgatgtca aattcaactg gtacgtgaat ggcgccgagg tgcaccatgc tcagacaaag      900

cccagagaaa ctcagtataa ctcaacctac cgggtcgtga gcgtcctcac cgtgacacac      960

caggactggc tgaacggcaa agagtataca tgcaaagtga gcaataaggc cctgcctgct     1020

ccaatccaga agactattag caaggataaa gggcagcctc gcgaaccaca ggtgtacacc     1080

ctgcctccca gcagggagga actgactaaa aaccaggtca gcctcacctg tctggtgaag     1140

ggcttctacc cttccgacat cgtcgtggag tgggaaagtt caggccagcc agagaatacc     1200

tacaagacta ccccacccgt gctggactct gatggaagtt atttcctcta cagcaaactg     1260

acagtggata agtccagatg gcagcagggc aacgtcttta gttgctcagt gatgcatgag     1320

gccctccaca atcattacac acagaaaagc ctgtccgtgt ctccccgggg caggaagagg     1380

agaagtggat caggcgcaac taacttcagc ctgctcaagc aggcagggga cgtggaggaa     1440

aatcccggac ctatggtcct gcagacccag gtgtttatct ccctgctcct gtggatttct     1500

ggcgcatacg gggccatcca gatgacacag agccccagct ccctgagcgc ctccgtcggc     1560

gaccgggtga ctatcacctg tcgcgctagc cagggaatta ggaacgatct gggctggtat     1620

cagcagaagc ccggcaaagc ccctaagctc ctgatctact ctgctagtac actgcagtcc     1680

ggggtgcctt ctaggttctc agggagcggc agcggcactg acttcaccct cactatttct     1740

agtctgcagc cagaggactt cgcaacctat tactgcctgc aggattataa ttacccctgg     1800

acatttgggc agggaactaa agtggagatc aagcgcgctg tcgctgcacc tagcgtgttc     1860

atctttcctc caagtgaaga ccaggtcaag agtggcaccg tgtcagtggt gtgcctcctg     1920

aacaatttct atccaaggga ggcctccgtg aagtggaaag tcgatggggt gctgaaaaca     1980

ggaaactcac aggagagcgt gactgaacag gacagtaagg ataataccta ctcactgtca     2040

agcaccctca cactgtcctc taccgactat cagtctcaca acgtgtacgc ttgcgaagtc     2100

acccaccagg ggctcagtag tccagtcaca aaatctttca atagaggcga atgt           2154


<210>  8
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9247: V2L2 with Rhesus Fc in pGX0001; 
       DMAb-antiPcrV

<400>  8

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Val Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ile 
    210                 215                 220                 


Lys Thr Cys Gly Gly Gly Ser Lys Pro Pro Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro Arg Glu Thr 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Thr His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Gln Lys Thr Ile Ser Lys Asp Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Val Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Thr 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Val Ser Pro Arg Gly Arg Lys Arg Arg Ser Gly Ser 
    450                 455                 460                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
465                 470                 475                 480 


Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu 
                485                 490                 495     


Leu Trp Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro 
            500                 505                 510         


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        515                 520                 525             


Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro 
    530                 535                 540                 


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser 
545                 550                 555                 560 


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                565                 570                 575     


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            580                 585                 590         


Leu Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 
        595                 600                 605             


Glu Ile Lys Arg Ala Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    610                 615                 620                 


Ser Glu Asp Gln Val Lys Ser Gly Thr Val Ser Val Val Cys Leu Leu 
625                 630                 635                 640 


Asn Asn Phe Tyr Pro Arg Glu Ala Ser Val Lys Trp Lys Val Asp Gly 
                645                 650                 655     


Val Leu Lys Thr Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            660                 665                 670         


Lys Asp Asn Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Ser Thr 
        675                 680                 685             


Asp Tyr Gln Ser His Asn Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    690                 695                 700                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
705                 710                 715             


<210>  9
<211>  2127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9248: Pseudo-V2L2MD rbFc; DMAb-antiPcrV

<400>  9
gaagtgcagc tgctggaatc tggagggggc ctggtgcagc ccggcggcag cctgaggctg       60

tcctgcgccg ccagcggctt caccttctcc agctacgcca tgaactgggt gcgccaggcc      120

ccaggcaagg gactggagtg ggtgtccgcc atcaccatga gcggcatcac cgcctactac      180

accgacgacg tgaagggccg cttcaccatc tcccgggaca acagcaagaa caccctgtac      240

ctgcagatga actccctgag ggccgaggac accgccgtgt actactgcgc caaggaggag      300

ttcctgccag gaacccacta ctactacgga atggacgtgt ggggacaggg aaccaccgtg      360

accgtgtcca gcggccagcc caaggccccc agcgtgttcc cactggcccc atgctgcggc      420

gacaccccct ccagcaccgt gaccctggga tgcctggtga agggatacct gccagagcca      480

gtgaccgtga cctggaactc cggcaccctg accaacggcg tgaggacctt cccaagcgtg      540

cgccagtcca gcggactgta ctccctgtcc agcgtggtga gcgtgacctc cagctcccag      600

ccagtgacct gcaacgtggc ccacccagcc accaacacca aggtggacaa gaccgtggcc      660

ccaagcacct gctccaagcc aacctgccct cctcccgagc tgctgggcgg cccctccgtg      720

ttcatcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaggtgacc      780

tgcgtggtgg tggacgtgag ccaggacgac cccgaggtgc agttcacctg gtacatcaac      840

aacgagcagg tgcggaccgc ccgccctccc ctgcgcgagc agcagttcaa ctccaccatc      900

cgggtggtga gcaccctgcc aatcacccac caggactggc tgaggggcaa ggagttcaag      960

tgcaaggtgc acaacaaggc cctgcccgcc cccatcgaga agaccatcag caaggccagg     1020

ggccagccac tggagcccaa ggtgtacacc atgggccctc cccgcgagga gctgagctcc     1080

aggagcgtgt ccctgacctg catgatcaac ggcttctacc ccagcgacat ctccgtggag     1140

tgggagaaga acggcaaggc cgaggacaac tacaagacca ccccagccgt gctggacagc     1200

gacggctcct acttcctgta caacaagctg tccgtgccca ccagcgagtg gcagcggggc     1260

gacgtgttca cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagagc     1320

atctccagga gccccggcaa gaggggaagg aagcgccggt ccggcagcgg agccaccaac     1380

ttcagcctgc tgaagcaggc cggcgacgtg gaggagaacc caggaccaat ggtgctgcag     1440

acccaggtgt tcatctccct gctgctgtgg atcagcggag cctacggagc catccagatg     1500

acccagtccc ccagctccct gtccgccagc gtgggcgaca gggtgaccat cacctgcagg     1560

gccagccagg gcatcaggaa cgacctgggc tggtaccagc agaagcccgg caaggccccc     1620

aagctgctga tctactccgc cagcaccctg cagtccggag tgcccagccg gttctccggc     1680

agcggctccg gaaccgactt caccctgacc atcagctccc tgcagcccga ggacttcgcc     1740

acctactact gcctgcagga ctacaactac ccctggacct tcggccaggg caccaaggtg     1800

gagatcaaga ggcagccagc cgtgacccca tccgtgatcc tgttccctcc ctcctccgag     1860

gagctgaagg acaacaaggc caccctggtg tgcctgatct ccgacttcta cccccgcacc     1920

gtgaaggtga actggaaggc cgacggaaac agcgtgaccc agggagtgga caccacccag     1980

ccaagcaagc agtccaacaa caagtacgcc gccagctcct tcctgcacct gaccgccaac     2040

cagtggaaga gctaccagtc cgtgacctgt caggtcaccc acgaagggca caccgtcgaa     2100

aaatctctgg cccccgccga atgttct                                         2127


<210>  10
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9248: Pseudo-V2L2MD rbFc; DMAb-antiPcrV

<400>  10

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gln Pro Lys 
        115                 120                 125             


Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser 
    130                 135                 140                 


Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr 
                165                 170                 175     


Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His 
        195                 200                 205             


Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys 
    210                 215                 220                 


Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg 
        275                 280                 285             


Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser 
    290                 295                 300                 


Thr Leu Pro Ile Thr His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys 
305                 310                 315                 320 


Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly 
            340                 345                 350         


Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met 
        355                 360                 365             


Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn 
    370                 375                 380                 


Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro Thr Ser Glu 
                405                 410                 415     


Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys Arg 
        435                 440                 445             


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
    450                 455                 460                 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
465                 470                 475                 480 


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
                485                 490                 495     


Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
            500                 505                 510         


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
        515                 520                 525             


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
    530                 535                 540                 


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
545                 550                 555                 560 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                565                 570                 575     


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
            580                 585                 590         


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gln Pro Ala Val 
        595                 600                 605             


Thr Pro Ser Val Ile Leu Phe Pro Pro Ser Ser Glu Glu Leu Lys Asp 
    610                 615                 620                 


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Arg Thr 
625                 630                 635                 640 


Val Lys Val Asn Trp Lys Ala Asp Gly Asn Ser Val Thr Gln Gly Val 
                645                 650                 655     


Asp Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
            660                 665                 670         


Ser Phe Leu His Leu Thr Ala Asn Gln Trp Lys Ser Tyr Gln Ser Val 
        675                 680                 685             


Thr Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser Leu Ala 
    690                 695                 700                 


Pro Ala Glu Cys Ser 
705                 


<210>  11
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9257 hc: Pseudo-V2L2MD in pGX0003 
       (sCMV-light chain, hCMV-heavy chain); DMAb-antiPcrV

<400>  11
gaggtgcagc tgctggagtc aggaggagga ctggtgcagc ccggcggatc actgcgactg       60

agctgcgcag cttccggctt caccttcagc agctatgcca tgaactgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgagtgca atcaccatgt cagggattac tgcctactat      180

accgacgatg tgaaaggccg attcactatc tctagggaca acagtaagaa taccctgtac      240

ctgcagatga attccctgcg cgctgaggat acagcagtgt actattgcgc caaggaggaa      300

ttcctgccag ggactcacta ctattacgga atggacgtgt ggggacaggg aaccacagtc      360

accgtgtcta gtgcaagcac aaaaggcccc tccgtgtttc ccctggcccc ttcaagcaag      420

tctacaagtg ggggcactgc agccctggga tgtctggtga aggattactt ccctgagcca      480

gtcaccgtga gctggaactc cggcgccctg acttccggag tccatacctt tcctgctgtg      540

ctgcagtcct ctggcctgta tagcctgagt tcagtggtca ccgtcccaag ctcctctctg      600

ggaacacaga cttacatctg caacgtgaat cacaaaccaa gcaatacaaa ggtcgacaag      660

aaagtggaac ccaaatcctg tgataagacc catacatgcc ctccctgtcc agcacctgag      720

ctgctgggag ggccaagcgt gttcctgttt ccacccaagc ctaaagacac actgatgatt      780

tctcggaccc ccgaagtcac atgcgtggtc gtggacgtga gccacgagga ccccgaagtc      840

aagtttaact ggtacgtgga tggcgtcgag gtgcataatg ccaagaccaa accacgagag      900

gaacagtata actctacata cagggtcgtg agtgtcctga ctgtgctgca ccaggactgg      960

ctgaacggga aggagtacaa gtgcaaagtg tccaacaagg ccctgccagc tcccatcgag     1020

aagaccattt ctaaggccaa aggccagcca agagaacccc aggtgtatac actgcctcca     1080

agtcgggacg agctgactaa aaaccaggtc tctctgacct gtctggtgaa gggattctac     1140

ccttccgata tcgctgtgga gtgggaatct aatgggcagc cagaaaacaa ttataagact     1200

acccctcccg tgctggactc tgatggaagt ttctttctgt actccaaact gaccgtggac     1260

aagtctagat ggcagcaggg gaacgtcttt tcatgcagcg tgatgcatga ggccctgcac     1320

aatcattaca ctcagaaatc cctgtctctg agtcctggga aa                        1362


<210>  12
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9257 hc: Pseudo-V2L2MD in pGX0003 
       (sCMV-light chain, hCMV-heavy chain); DMAb-antiPcrV

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  13
<211>  2151
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9258: Psuedo-V2L2MD-YTE only in 
       pGX0001; DMAb-antiPcrV

<400>  13
gaggtgcagc tgctggagtc aggaggagga ctggtgcagc ccggcggatc actgcgactg       60

agctgcgcag cttccggctt caccttcagc agctatgcca tgaactgggt ccgacaggct      120

cctggcaagg gactggaatg ggtgagtgca atcaccatgt cagggattac tgcctactat      180

accgacgatg tgaaaggccg attcactatc tctagggaca acagtaagaa taccctgtac      240

ctgcagatga attccctgcg cgctgaggat acagcagtgt actattgcgc caaggaggaa      300

ttcctgccag ggactcacta ctattacgga atggacgtgt ggggacaggg aaccacagtc      360

accgtgtcta gtgcaagcac aaaaggcccc tccgtgtttc ccctggcccc ttcaagcaag      420

tctacaagtg ggggcactgc agccctggga tgtctggtga aggattactt ccctgagcca      480

gtcaccgtga gctggaactc cggcgccctg acttccggag tccatacctt tcctgctgtg      540

ctgcagtcct ctggcctgta tagcctgagt tcagtggtca ccgtcccaag ctcctctctg      600

ggaacacaga cttacatctg caacgtgaat cacaaaccaa gcaatacaaa ggtcgacaag      660

aaagtggaac ccaaatcctg tgataagacc catacatgcc ctccctgtcc agcacctgag      720

ctgctgggag ggccaagcgt gttcctgttt ccacccaagc ctaaagacac actgtacatt      780

actcgggagc ccgaagtcac atgcgtggtc gtggacgtga gccacgagga ccccgaagtc      840

aagtttaact ggtacgtgga tggcgtcgag gtgcataatg ccaagaccaa accacgagag      900

gaacagtata actctacata cagggtcgtg agtgtcctga ctgtgctgca ccaggactgg      960

ctgaacggga aggagtacaa gtgcaaagtg tccaacaagg ccctgccagc tcccatcgag     1020

aagaccattt ctaaggccaa aggccagcca agagaacccc aggtgtatac actgcctcca     1080

agtcgggacg agctgactaa aaaccaggtc tctctgacct gtctggtgaa gggattctac     1140

ccttccgata tcgctgtgga gtgggaatct aatgggcagc cagaaaacaa ttataagact     1200

acccctcccg tgctggactc tgatggaagt ttctttctgt actccaaact gaccgtggac     1260

aagtctagat ggcagcaggg gaacgtcttt tcatgcagcg tgatgcatga ggccctgcac     1320

aatcattaca ctcagaaatc cctgtctctg agtcctggga aacggggccg caagaggaga     1380

tcaggaagcg gggccaccaa cttctccctg ctgaagcagg ctggcgatgt ggaggaaaat     1440

cctggaccaa tggtcctgca gactcaggtg tttatctcac tgctgctgtg gattagcgga     1500

gcatacgggg ccattcagat gacccagtcc cccagttcac tgtccgcttc tgtcggcgac     1560

agagtgacta tcacctgtcg ggcaagccag ggaattcgca acgatctggg gtggtatcag     1620

cagaagcctg ggaaagctcc aaagctgctg atctacagtg catcaactct gcagtcagga     1680

gtgcctagcc ggttcagcgg ctccggatct ggaaccgact ttacactgac tattagctcc     1740

ctgcagccag aggacttcgc cacatattac tgcctgcagg attataatta cccctggaca     1800

tttggccagg gaactaaagt ggaaatcaag cgcacagtcg ctgcacctag cgtgttcatc     1860

tttccaccct cagacgagca gctgaagtcc ggaactgctt ctgtggtgtg cctgctgaac     1920

aatttctatc caagggaagc aaaagtccag tggaaggtgg ataacgccct gcagtcaggc     1980

aatagccagg agtccgtgac cgaacaggac tctaaagata gtacatacag tctgtcaaac     2040

accctgacac tgagcaaggc tgattatgag aagcacaaag tgtacgcatg cgaagtcacc     2100

caccaggggc tgtcctcacc agtcacaaaa tctttcaatc ggggagaatg c              2151


<210>  14
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9258: Psuedo-V2L2MD-YTE only in 
       pGX0001; DMAb-antiPcrV

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly 
    450                 455                 460                 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
465                 470                 475                 480 


Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu 
                485                 490                 495     


Trp Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser 
            500                 505                 510         


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        515                 520                 525             


Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly 
    530                 535                 540                 


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly 
545                 550                 555                 560 


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                565                 570                 575     


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu 
            580                 585                 590         


Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu 
        595                 600                 605             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    610                 615                 620                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
625                 630                 635                 640 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                645                 650                 655     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            660                 665                 670         


Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp 
        675                 680                 685             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    690                 695                 700                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
705                 710                 715         


<210>  15
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9257 lc: Pseudo-V2L2MD in pGX0003 
       (sCMV-light chain, hCMV-heavy chain); DMAb-antiPcrV

<400>  15
gccattcaga tgacccagtc ccccagttca ctgtccgctt ctgtcggcga cagagtgact       60

atcacctgtc gggcaagcca gggaattcgc aacgatctgg ggtggtatca gcagaagcct      120

gggaaagctc caaagctgct gatctacagt gcatcaactc tgcagtcagg agtgcctagc      180

cggttcagcg gctccggatc tggaaccgac tttacactga ctattagctc cctgcagcca      240

gaggacttcg ccacatatta ctgcctgcag gattataatt acccctggac atttggccag      300

ggaactaaag tggaaatcaa gcgcacagtc gctgcaccta gcgtgttcat ctttccaccc      360

tcagacgagc agctgaagtc cggaactgct tctgtggtgt gcctgctgaa caatttctat      420

ccaagggaag caaaagtcca gtggaaggtg gataacgccc tgcagtcagg caatagccag      480

gagtccgtga ccgaacagga ctctaaagat agtacataca gtctgtcaaa caccctgaca      540

ctgagcaagg ctgattatga gaagcacaaa gtgtacgcat gcgaagtcac ccaccagggg      600

ctgtcctcac cagtcacaaa atctttcaat cggggagaat gc                         642


<210>  16
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9257 lc: Pseudo-V2L2MD in pGX0003 
       (sCMV-light chain, hCMV-heavy chain); DMAb-antiPcrV

<400>  16

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  17
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9213: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096); DMAb-BiSPA

<400>  17
gaagtgcagc tgctggagtc agggggaggg ctggtgcagc ccggcggcag cctgcgactg       60

tcttgcgccg ctagtggctt caccttcagc agctatgcta tgaactgggt ccgacaggca      120

ccaggaaagg gactggaatg ggtgtctgcc atcaccatga gtggaattac agcttactat      180

actgacgatg tgaaggggag attcacaatc tcacgggaca acagcaaaaa tactctgtac      240

ctgcagatga atagcctgag ggcagaggat accgccgtgt actattgcgc caaggaggaa      300

ttcctgcctg gcacacacta ctattacgga atggacgtgt ggggccaggg aaccacagtc      360

accgtgtcta gtgcttcaac aaaggggcca agcgtgtttc cactggcacc ctcaagcaaa      420

tcaaccagcg ggggcacagc agccctggga tgtctggtga aggattactt ccccgagcct      480

gtcaccgtgt catggaacag cggagccctg acctccggag tccacacatt tcctgctgtg      540

ctgcagtcct ctgggctgta ttctctgagt tcagtggtca cagtcccaag ctcctctctg      600

ggcacacaga cttacatctg caacgtgaat cataagccat ccaatactaa ggtcgacaaa      660

cgggtggagc ccaaatcttg tggcggcggc ggcagcggcg gcggcggcag ccaggtccag      720

ctgcaggaga gcggacctgg actggtgaag ccatccgaaa cactgtctct gacctgcacc      780

gtgagcggcg gcagcatctc tccatattac tggacttgga ttaggcagcc ccctggcaag      840

tgtctggagc tgatcgggta cattcacagt tcaggctata ccgactacaa cccctccctg      900

aagtctagag tgactatcag tggcgatacc tcaaagaaac agttctccct gaaactgagc      960

tccgtcactg ctgcagacac cgccgtgtat tactgcgcac gcgccgactg ggatcgactg     1020

cgcgctctgg atatctgggg acaggggact atggtcaccg tgtctagtgg gggcggaggg     1080

agtggcggag ggggctcagg agggggcgga agcgggggcg gagggtccga cattcagctg     1140

acccagagcc cctcaagcct gagtgcctca gtcggcgatc gcgtgactat cacctgtcga     1200

gctagccagt ccattaggtc ccatctgaac tggtatcagc agaagcccgg aaaagcacct     1260

aagctgctga tctacggcgc cagcaatctg cagtccggag tgccctctag gttctctggc     1320

agtggatcag ggacagactt tacactgact atttcctctc tgcagcctga ggatttcgca     1380

acttattact gccagcagag caccggcgcc tggaactggt ttggctgtgg aaccaaggtg     1440

gaaatcaaag gcggaggggg ctctggaggg ggcggaagtg acaagaccca cacatgccca     1500

ccctgtccag caccagagct gctgggcggc ccatccgtgt tcctgtttcc tccaaagcct     1560

aaagatacac tgatgattag cagaacaccc gaagtcactt gcgtggtcgt ggacgtgtcc     1620

cacgaggacc ccgaagtcaa gtttaactgg tacgtggacg gcgtcgaggt gcataatgcc     1680

aagaccaaac cccgagagga acagtataac tcaacctaca gggtcgtgag cgtcctgaca     1740

gtgctgcatc aggattggct gaacggcaag gagtacaagt gcaaagtgtc taataaggct     1800

ctgcctgcac caatcgagaa aactattagc aaggccaaag gccagcctag agaaccacag     1860

gtgtataccc tgcccccttc tcgggaggaa atgacaaaga accaggtcag cctgacttgt     1920

ctggtgaaag gcttctaccc ttctgacatc gctgtggagt gggaaagtaa tggacagcca     1980

gaaaacaatt ataagactac cccacccgtc ctggacagtg atggctcatt ctttctgtac     2040

agtaagctga ccgtggataa atcaaggtgg cagcagggaa acgtctttag ctgctccgtg     2100

atgcacgagg ccctgcacaa tcattacaca cagaagtctc tgagtctgtc acctggcaag     2160

cgaggaagga aaaggagaag cgggtccgga gcaaccaact tcagcctgct gaaacaggct     2220

ggggacgtgg aggaaaatcc cggccctatg gtcctgcaga cccaggtgtt tatctccctg     2280

ctgctgtgga tttctggggc ctacggcgct atccagatga cacagtctcc tagttcactg     2340

tctgcaagtg tcggcgacag agtgactatc acctgtcggg cttcccaggg aattcgcaac     2400

gatctggggt ggtatcagca gaaaccagga aaggctccca aactgctgat ctactcagca     2460

agcacactgc agagtggggt gccatcaaga ttctccggat ctgggagtgg cactgacttc     2520

accctgacta ttagctccct gcagccagag gacttcgcca cctattactg cctgcaggat     2580

tataattacc cctggacatt tggacagggg actaaggtgg agatcaaacg gactgtcgcc     2640

gctcccagcg tgttcatttt tcctccatcc gacgaacagc tgaagagcgg aaccgcatcc     2700

gtggtgtgcc tgctgaacaa tttctatcct cgcgaagcaa aggtccagtg gaaagtggat     2760

aacgccctgc agagcggcaa ttcccaggag tctgtgactg aacaggacag taaggattca     2820

acctacagcc tgtctagtac cctgacactg tccaaagctg actatgagaa gcataaagtg     2880

tacgcatgtg aggtcaccca ccaggggctg tccagtccag tcaccaagtc tttcaatagg     2940

ggcgaatgc                                                             2949


<210>  18
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9213: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096); DMAb-BiSPA

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
225                 230                 235                 240 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
                245                 250                 255     


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Pro Tyr Tyr Trp Thr 
            260                 265                 270         


Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile Gly Tyr Ile 
        275                 280                 285             


His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val 
    290                 295                 300                 


Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu Lys Leu Ser 
305                 310                 315                 320 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Asp 
                325                 330                 335     


Trp Asp Arg Leu Arg Ala Leu Asp Ile Trp Gly Gln Gly Thr Met Val 
            340                 345                 350         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
    370                 375                 380                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
385                 390                 395                 400 


Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln Gln Lys Pro 
                405                 410                 415     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Gln Ser 
            420                 425                 430         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        435                 440                 445             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    450                 455                 460                 


Gln Gln Ser Thr Gly Ala Trp Asn Trp Phe Gly Cys Gly Thr Lys Val 
465                 470                 475                 480 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 
                485                 490                 495     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            500                 505                 510         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        515                 520                 525             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    530                 535                 540                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
545                 550                 555                 560 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                565                 570                 575     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            580                 585                 590         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        595                 600                 605             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    610                 615                 620                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
625                 630                 635                 640 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                645                 650                 655     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            660                 665                 670         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        675                 680                 685             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    690                 695                 700                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715                 720 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                725                 730                 735     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
            740                 745                 750         


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
        755                 760                 765             


Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    770                 775                 780                 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
785                 790                 795                 800 


Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
                805                 810                 815     


Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
            820                 825                 830         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        835                 840                 845             


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro 
    850                 855                 860                 


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
865                 870                 875                 880 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                885                 890                 895     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            900                 905                 910         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        915                 920                 925             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    930                 935                 940                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
945                 950                 955                 960 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                965                 970                 975     


Ser Phe Asn Arg Gly Glu Cys 
            980             


<210>  19
<211>  2136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9215: Pseudo-Ps10096; DMAb-antiPsl

<400>  19
caggtgcagc tgcaggagtc tggacccgga ctggtcaagc ctagcgaaac tctgtccctg       60

acttgcaccg tgtccggcgg atcaatcagc ccatactatt ggacctggat tcgccagccc      120

cctggcaagg gactggagct gatcggctac attcacagct ccggatacac cgactataac      180

ccatcactga aaagccgagt gacaatctct ggcgatacta gtaagaaaca gttcagcctg      240

aagctgtcta gtgtcacagc cgctgacact gcagtgtact attgcgcccg cgctgactgg      300

gatcgactgc gcgctctgga tatttggggg cagggcacta tggtcaccgt gagcagcgcc      360

tcaaccaaag gccctagcgt gtttccactg gcaccctcct ctaagtccac ctctgggggc      420

acagcagccc tgggatgtct ggtgaaggac tacttccccg agcctgtcac agtgtcctgg      480

aactctggag ccctgacctc cggggtccat acatttcccg ctgtgctgca gagttcaggg      540

ctgtactctc tgagctccgt ggtcaccgtg ccttctagtt cactgggcac acagacttat      600

atctgcaacg tgaatcacaa accttccaat acaaaggtcg acaagaaagt ggaaccaaaa      660

tcttgtgata agacccatac atgcccaccc tgtccagcac cagagctgct gggagggcca      720

tccgtgttcc tgtttcctcc aaagcccaaa gacaccctga tgattagccg gactccagaa      780

gtcacctgcg tggtcgtgga cgtgtcccac gaggaccccg aagtcaagtt caactggtac      840

gtggatggcg tcgaggtgca taatgccaag acaaaacccc gagaggaaca gtacaactcc      900

acttataggg tcgtgtctgt cctgaccgtg ctgcaccagg attggctgaa cgggaaggag      960

tataagtgca aagtgtctaa caaggccctg cctgccccaa tcgagaagac cattagcaag     1020

gccaaaggcc agcctagaga accacaggtg tacacactgc cccctagtcg ggacgagctg     1080

actaaaaacc aggtcagcct gacctgtctg gtgaagggct tctatccctc agatatcgct     1140

gtggagtggg aatctaatgg acagcctgaa aacaattaca agaccacacc acccgtgctg     1200

gacagtgatg gatcattctt tctgtatagc aaactgaccg tggacaagtc cagatggcag     1260

caggggaacg tctttagttg ctcagtgatg cacgaggccc tgcacaatca ttacactcag     1320

aaaagcctgt ccctgtctcc cggcaaacga ggaaggaaga ggagaagtgg atcaggggcc     1380

acaaacttca gcctgctgaa gcaggctggg gatgtggagg aaaatcccgg ccctatggtc     1440

ctgcagacac aggtgtttat cagtctgctg ctgtggattt caggggccta tggcgacatc     1500

cagctgactc agtcccctag ctccctgagc gcctccgtcg gagatagagt gactatcacc     1560

tgtcgggctt ctcagagtat tcgcagccat ctgaactggt accagcagaa gcccgggaaa     1620

gctcctaagc tgctgatcta tggagcatca aatctgcaga gcggagtgcc atcccggttc     1680

tcaggcagcg gcagcggaac cgactttaca ctgactattt ctagtctgca gcccgaggat     1740

ttcgcaacat actattgcca gcagtccact ggcgcctgga actggtttgg cggagggacc     1800

aaagtggaaa tcaagcgcac agtcgctgca cctagcgtgt tcatctttcc tccaagtgac     1860

gagcagctga agtctggcac cgccagtgtg gtgtgcctgc tgaacaattt ctacccaagg     1920

gaagcaaaag tccagtggaa ggtggataac gccctgcaga gcggaaattc ccaggagtct     1980

gtgacagaac aggacagtaa ggattcaact tactctctga gtaacaccct gacactgagc     2040

aaggctgact acgagaagca caaagtgtat gcatgcgagg tcacccacca ggggctgtcc     2100

agtccagtca ctaagtcctt caatagggga gaatgc                               2136


<210>  20
<211>  712
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9215: Pseudo-Ps10096; DMAb-antiPsl

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Pro Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Leu Ile 
        35                  40                  45              


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Asp Trp Asp Arg Leu Arg Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
    450                 455                 460                 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
465                 470                 475                 480 


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
                485                 490                 495     


Tyr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            500                 505                 510         


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg 
        515                 520                 525             


Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    530                 535                 540                 


Leu Ile Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                565                 570                 575     


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Thr Gly Ala 
            580                 585                 590         


Trp Asn Trp Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
        595                 600                 605             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    610                 615                 620                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
625                 630                 635                 640 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                645                 650                 655     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            660                 665                 670         


Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        675                 680                 685             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    690                 695                 700                 


Lys Ser Phe Asn Arg Gly Glu Cys 
705                 710         


<210>  21
<211>  2949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9259: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096)-YTE only pGX0001; DMAb-BiSPA

<400>  21
gaagtgcagc tgctggagtc agggggaggg ctggtgcagc ccggcggcag cctgcgactg       60

tcttgcgccg ctagtggctt caccttcagc agctatgcta tgaactgggt ccgacaggca      120

ccaggaaagg gactggaatg ggtgtctgcc atcaccatga gtggaattac agcttactat      180

actgacgatg tgaaggggag attcacaatc tcacgggaca acagcaaaaa tactctgtac      240

ctgcagatga atagcctgag ggcagaggat accgccgtgt actattgcgc caaggaggaa      300

ttcctgcctg gcacacacta ctattacgga atggacgtgt ggggccaggg aaccacagtc      360

accgtgtcta gtgcttcaac aaaggggcca agcgtgtttc cactggcacc ctcaagcaaa      420

tcaaccagcg ggggcacagc agccctggga tgtctggtga aggattactt ccccgagcct      480

gtcaccgtgt catggaacag cggagccctg acctccggag tccacacatt tcctgctgtg      540

ctgcagtcct ctgggctgta ttctctgagt tcagtggtca cagtcccaag ctcctctctg      600

ggcacacaga cttacatctg caacgtgaat cataagccat ccaatactaa ggtcgacaaa      660

cgggtggagc ccaaatcttg tggcggcggc ggcagcggcg gcggcggcag ccaggtccag      720

ctgcaggaga gcggacctgg actggtgaag ccatccgaaa cactgtctct gacctgcacc      780

gtgagcggcg gcagcatctc tccatattac tggacttgga ttaggcagcc ccctggcaag      840

tgtctggagc tgatcgggta cattcacagt tcaggctata ccgactacaa cccctccctg      900

aagtctagag tgactatcag tggcgatacc tcaaagaaac agttctccct gaaactgagc      960

tccgtcactg ctgcagacac cgccgtgtat tactgcgcac gcgccgactg ggatcgactg     1020

cgcgctctgg atatctgggg acaggggact atggtcaccg tgtctagtgg gggcggaggg     1080

agtggcggag ggggctcagg agggggcgga agcgggggcg gagggtccga cattcagctg     1140

acccagagcc cctcaagcct gagtgcctca gtcggcgatc gcgtgactat cacctgtcga     1200

gctagccagt ccattaggtc ccatctgaac tggtatcagc agaagcccgg aaaagcacct     1260

aagctgctga tctacggcgc cagcaatctg cagtccggag tgccctctag gttctctggc     1320

agtggatcag ggacagactt tacactgact atttcctctc tgcagcctga ggatttcgca     1380

acttattact gccagcagag caccggcgcc tggaactggt ttggctgtgg aaccaaggtg     1440

gaaatcaaag gcggaggggg ctctggaggg ggcggaagtg acaagaccca cacatgccca     1500

ccctgtccag caccagagct gctgggcggc ccatccgtgt tcctgtttcc tccaaagcct     1560

aaagatacac tgtatattac tagagagccc gaagtcactt gcgtggtcgt ggacgtgtcc     1620

cacgaggacc ccgaagtcaa gtttaactgg tacgtggacg gcgtcgaggt gcataatgcc     1680

aagaccaaac cccgagagga acagtataac tcaacctaca gggtcgtgag cgtcctgaca     1740

gtgctgcatc aggattggct gaacggcaag gagtacaagt gcaaagtgtc taataaggct     1800

ctgcctgcac caatcgagaa aactattagc aaggccaaag gccagcctag agaaccacag     1860

gtgtataccc tgcccccttc tcgggaggaa atgacaaaga accaggtcag cctgacttgt     1920

ctggtgaaag gcttctaccc ttctgacatc gctgtggagt gggaaagtaa tggacagcca     1980

gaaaacaatt ataagactac cccacccgtc ctggacagtg atggctcatt ctttctgtac     2040

agtaagctga ccgtggataa atcaaggtgg cagcagggaa acgtctttag ctgctccgtg     2100

atgcacgagg ccctgcacaa tcattacaca cagaagtctc tgagtctgtc acctggcaag     2160

cgaggaagga aaaggagaag cgggtccgga gcaaccaact tcagcctgct gaaacaggct     2220

ggggacgtgg aggaaaatcc cggccctatg gtcctgcaga cccaggtgtt tatctccctg     2280

ctgctgtgga tttctggggc ctacggcgct atccagatga cacagtctcc tagttcactg     2340

tctgcaagtg tcggcgacag agtgactatc acctgtcggg cttcccaggg aattcgcaac     2400

gatctggggt ggtatcagca gaaaccagga aaggctccca aactgctgat ctactcagca     2460

agcacactgc agagtggggt gccatcaaga ttctccggat ctgggagtgg cactgacttc     2520

accctgacta ttagctccct gcagccagag gacttcgcca cctattactg cctgcaggat     2580

tataattacc cctggacatt tggacagggg actaaggtgg agatcaaacg gactgtcgcc     2640

gctcccagcg tgttcatttt tcctccatcc gacgaacagc tgaagagcgg aaccgcatcc     2700

gtggtgtgcc tgctgaacaa tttctatcct cgcgaagcaa aggtccagtg gaaagtggat     2760

aacgccctgc agagcggcaa ttcccaggag tctgtgactg aacaggacag taaggattca     2820

acctacagcc tgtctagtac cctgacactg tccaaagctg actatgagaa gcataaagtg     2880

tacgcatgtg aggtcaccca ccaggggctg tccagtccag tcaccaagtc tttcaatagg     2940

ggcgaatgc                                                             2949


<210>  22
<211>  983
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9259: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096)-YTE only pGX0001; DMAb-BiSPA

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
225                 230                 235                 240 


Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
                245                 250                 255     


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Pro Tyr Tyr Trp Thr 
            260                 265                 270         


Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile Gly Tyr Ile 
        275                 280                 285             


His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val 
    290                 295                 300                 


Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu Lys Leu Ser 
305                 310                 315                 320 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Asp 
                325                 330                 335     


Trp Asp Arg Leu Arg Ala Leu Asp Ile Trp Gly Gln Gly Thr Met Val 
            340                 345                 350         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
    370                 375                 380                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
385                 390                 395                 400 


Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln Gln Lys Pro 
                405                 410                 415     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Gln Ser 
            420                 425                 430         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        435                 440                 445             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    450                 455                 460                 


Gln Gln Ser Thr Gly Ala Trp Asn Trp Phe Gly Cys Gly Thr Lys Val 
465                 470                 475                 480 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 
                485                 490                 495     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            500                 505                 510         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg 
        515                 520                 525             


Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    530                 535                 540                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
545                 550                 555                 560 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                565                 570                 575     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            580                 585                 590         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        595                 600                 605             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    610                 615                 620                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
625                 630                 635                 640 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                645                 650                 655     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            660                 665                 670         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        675                 680                 685             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    690                 695                 700                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715                 720 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
                725                 730                 735     


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
            740                 745                 750         


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
        755                 760                 765             


Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    770                 775                 780                 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn 
785                 790                 795                 800 


Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
                805                 810                 815     


Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
            820                 825                 830         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        835                 840                 845             


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro 
    850                 855                 860                 


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
865                 870                 875                 880 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                885                 890                 895     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            900                 905                 910         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        915                 920                 925             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    930                 935                 940                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
945                 950                 955                 960 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                965                 970                 975     


Ser Phe Asn Arg Gly Glu Cys 
            980             


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin cleavage sequence

<400>  23

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide amino acid sequence

<400>  24

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala 
            


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide amino acid sequence

<400>  25

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly 
            20  


<210>  26
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9308: V2L2MD heavy chain operably 
       linked to a sequence encoding an IgE leader sequence

<400>  26
atggactgga cctggagaat cctgttcctg gtggcagcag caaccggaac acacgcagag       60

gtgcagctgc tggagagcgg cggcggcctg gtgcagcctg gcggcagcct gaggctgtcc      120

tgcgcagcat ctggcttcac ctttagctcc tatgcaatga actgggtgcg ccaggcacca      180

ggcaagggac tggagtgggt gtctgccatc acaatgagcg gcatcaccgc ctactataca      240

gacgatgtga agggcaggtt taccatcagc agagacaact ccaagaatac actgtacctg      300

cagatgaata gcctgagagc cgaggatacc gccgtgtact attgcgccaa ggaggagttc      360

ctgcccggca cacactacta ttacggaatg gacgtgtggg gacagggaac cacagtgacc      420

gtgtctagcg cctccacaaa gggacctagc gtgttcccac tggcaccctc ctctaagtcc      480

acctctggcg gcacagccgc cctgggctgt ctggtgaagg attatttccc agagcccgtg      540

accgtgtctt ggaacagcgg cgccctgacc tctggagtgc acacatttcc agccgtgctg      600

cagagctccg gcctgtatag cctgtctagc gtggtgaccg tgccctcctc tagcctgggc      660

acccagacat acatctgcaa cgtgaatcac aagccatcta atacaaaggt ggacaagaag      720

gtggagccca agagctgtga taagacccac acatgccctc cctgtcctgc accagagctg      780

ctgggcggcc catccgtgtt cctgtttcca cccaagccta aggacaccct gatgatctcc      840

cggaccccag aggtgacatg cgtggtggtg gacgtgtctc acgaggaccc cgaggtgaag      900

ttcaactggt acgtggatgg cgtggaggtg cacaatgcca agaccaagcc acgggaggag      960

cagtataaca gcacctaccg cgtggtgtcc gtgctgacag tgctgcacca ggactggctg     1020

aacggcaagg agtacaagtg caaggtgagc aataaggccc tgcccgcccc tatcgagaag     1080

accatctcca aggccaaggg ccagcctagg gagccacagg tgtatacact gcctccaagc     1140

agagacgagc tgaccaagaa ccaggtgtcc ctgacatgtc tggtgaaggg cttctaccct     1200

tccgatatcg ccgtggagtg ggagtctaat ggccagccag agaacaatta taagaccaca     1260

ccccctgtgc tggactccga tggctctttc tttctgtact ctaagctgac cgtggataag     1320

agccgctggc agcagggcaa cgtgtttagc tgttccgtga tgcacgaggc cctgcacaat     1380

cactacacac agaagtctct gagcctgtcc cctggcaag                            1419


<210>  27
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9308: V2L2MD heavy chain operably 
       linked to an IgE leader sequence

<400>  27

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  28
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9309: V2L2MD light chain operably 
       linked to a sequence encoding an IgE leader sequence

<400>  28
atggtgctgc agacacaggt gttcatcagc ctgctgctgt ggatctccgg agcatacgga       60

gcaatccaga tgacccagtc cccaagctcc ctgagcgcct ccgtgggcga cagggtgacc      120

atcacatgca gagcctctca gggcatccgg aacgatctgg gctggtacca gcagaagcca      180

ggcaaggccc ccaagctgct gatctattct gccagcaccc tgcagtctgg agtgcccagc      240

cggttctccg gctctggcag cggaacagac tttaccctga caatctctag cctgcagcct      300

gaggacttcg ccacctacta ttgcctgcag gattacaatt atccatggac ctttggccag      360

ggcacaaagg tggagatcaa gcgcacagtg gccgccccca gcgtgttcat ctttccccct      420

agcgacgagc agctgaagtc cggcaccgcc tctgtggtgt gcctgctgaa caatttctac      480

cctagggagg ccaaggtgca gtggaaggtg gataacgccc tgcagagcgg caattcccag      540

gagtctgtga ccgagcagga cagcaaggat tccacatatt ccctgtctaa caccctgaca      600

ctgagcaagg ccgattacga gaagcacaag gtgtatgcat gcgaggtgac ccaccaggga      660

ctgtcctctc ccgtgacaaa gtcctttaat aggggcgagt gt                         702


<210>  29
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9309: V2L2MD light chain operably 
       linked to an IgE leader sequence

<400>  29

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  30
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9214: Pseudo-V2L2MD; DMAb-?PcrV 
       operably linked to a sequence encoding an IgE leader sequence

<400>  30
atggattgga catggaggat tctgtttctg gtcgccgccg ctactggaac ccacgccgag       60

gtgcagctgc tggagtcagg aggaggactg gtgcagcccg gcggatcact gcgactgagc      120

tgcgcagctt ccggcttcac cttcagcagc tatgccatga actgggtccg acaggctcct      180

ggcaagggac tggaatgggt gagtgcaatc accatgtcag ggattactgc ctactatacc      240

gacgatgtga aaggccgatt cactatctct agggacaaca gtaagaatac cctgtacctg      300

cagatgaatt ccctgcgcgc tgaggataca gcagtgtact attgcgccaa ggaggaattc      360

ctgccaggga ctcactacta ttacggaatg gacgtgtggg gacagggaac cacagtcacc      420

gtgtctagtg caagcacaaa aggcccctcc gtgtttcccc tggccccttc aagcaagtct      480

acaagtgggg gcactgcagc cctgggatgt ctggtgaagg attacttccc tgagccagtc      540

accgtgagct ggaactccgg cgccctgact tccggagtcc atacctttcc tgctgtgctg      600

cagtcctctg gcctgtatag cctgagttca gtggtcaccg tcccaagctc ctctctggga      660

acacagactt acatctgcaa cgtgaatcac aaaccaagca atacaaaggt cgacaagaaa      720

gtggaaccca aatcctgtga taagacccat acatgccctc cctgtccagc acctgagctg      780

ctgggagggc caagcgtgtt cctgtttcca cccaagccta aagacacact gatgatttct      840

cggacccccg aagtcacatg cgtggtcgtg gacgtgagcc acgaggaccc cgaagtcaag      900

tttaactggt acgtggatgg cgtcgaggtg cataatgcca agaccaaacc acgagaggaa      960

cagtataact ctacatacag ggtcgtgagt gtcctgactg tgctgcacca ggactggctg     1020

aacgggaagg agtacaagtg caaagtgtcc aacaaggccc tgccagctcc catcgagaag     1080

accatttcta aggccaaagg ccagccaaga gaaccccagg tgtatacact gcctccaagt     1140

cgggacgagc tgactaaaaa ccaggtctct ctgacctgtc tggtgaaggg attctaccct     1200

tccgatatcg ctgtggagtg ggaatctaat gggcagccag aaaacaatta taagactacc     1260

cctcccgtgc tggactctga tggaagtttc tttctgtact ccaaactgac cgtggacaag     1320

tctagatggc agcaggggaa cgtcttttca tgcagcgtga tgcatgaggc cctgcacaat     1380

cattacactc agaaatccct gtctctgagt cctgggaaac ggggccgcaa gaggagatca     1440

ggaagcgggg ccaccaactt ctccctgctg aagcaggctg gcgatgtgga ggaaaatcct     1500

ggaccaatgg tcctgcagac tcaggtgttt atctcactgc tgctgtggat tagcggagca     1560

tacggggcca ttcagatgac ccagtccccc agttcactgt ccgcttctgt cggcgacaga     1620

gtgactatca cctgtcgggc aagccaggga attcgcaacg atctggggtg gtatcagcag     1680

aagcctggga aagctccaaa gctgctgatc tacagtgcat caactctgca gtcaggagtg     1740

cctagccggt tcagcggctc cggatctgga accgacttta cactgactat tagctccctg     1800

cagccagagg acttcgccac atattactgc ctgcaggatt ataattaccc ctggacattt     1860

ggccagggaa ctaaagtgga aatcaagcgc acagtcgctg cacctagcgt gttcatcttt     1920

ccaccctcag acgagcagct gaagtccgga actgcttctg tggtgtgcct gctgaacaat     1980

ttctatccaa gggaagcaaa agtccagtgg aaggtggata acgccctgca gtcaggcaat     2040

agccaggagt ccgtgaccga acaggactct aaagatagta catacagtct gtcaaacacc     2100

ctgacactga gcaaggctga ttatgagaag cacaaagtgt acgcatgcga agtcacccac     2160

caggggctgt cctcaccagt cacaaaatct ttcaatcggg gagaatgc                  2208


<210>  31
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9214: Pseudo-V2L2MD; DMAb-?PcrV 
       operably linked to an IgE leader sequence

<400>  31

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln 
        515                 520                 525             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    530                 535                 540                 


Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln 
545                 550                 555                 560 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu 
                565                 570                 575     


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            580                 585                 590         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        595                 600                 605             


Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
625                 630                 635                 640 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                645                 650                 655     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            660                 665                 670         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        675                 680                 685             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser 
    690                 695                 700                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
705                 710                 715                 720 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735     


<210>  32
<211>  2217
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9247: V2L2 with Rhesus Fc in pGX0001; 
       DMAb-?PcrV operably linked to a sequence encoding an IgE leader 
       sequence

<400>  32
atggactgga catggagaat cctgttcctg gtcgccgccg ctactgggac tcacgccgag       60

gtgcagctcc tggaaagtgg gggagggctg gtgcagcccg gcgggtccct cagactgtct      120

tgcgccgcta gtggcttcac ctttagctcc tatgcaatga actgggtgcg gcaggcacct      180

gggaaaggac tggagtgggt gagcgccatc accatgtccg gcattactgc atactatacc      240

gacgatgtga aagggaggtt cacaatctca agagacaaca gcaagaatac tctctacctg      300

cagatgaata gcctgcgcgc tgaggatact gcagtgtact attgcgccaa ggaggaattc      360

ctgccaggca cccactacta ttacggaatg gacgtgtggg gacagggaac cacagtcacc      420

gtgtctagtg cttctacaaa agggcccagc gtgttcccac tggcaccctc aagcaggagt      480

acatcagaga gcactgcagc cctcggatgt ctggtgaagg attacttccc cgaacctgtc      540

accgtgtcct ggaactccgg atctctcact tctggcgtcc acacctttcc cgccgtgctg      600

cagtcctctg ggctctatag cctgagttca gtggtcaccg tgcctagctc ctctctggga      660

acacagactt acgtctgcaa cgtgaatcat aagccatcca atacaaaggt cgacaaaaga      720

gtggagatca aaacctgtgg aggcgggtct aagcccccta catgcccacc ctgtccagca      780

ccagaactgc tcggaggccc aagcgtgttc ctctttcctc caaagcccaa agacaccctg      840

atgatttccc ggaccccaga ggtcacatgc gtggtcgtgg acgtgagcca ggaagaccct      900

gatgtcaaat tcaactggta cgtgaatggc gccgaggtgc accatgctca gacaaagccc      960

agagaaactc agtataactc aacctaccgg gtcgtgagcg tcctcaccgt gacacaccag     1020

gactggctga acggcaaaga gtatacatgc aaagtgagca ataaggccct gcctgctcca     1080

atccagaaga ctattagcaa ggataaaggg cagcctcgcg aaccacaggt gtacaccctg     1140

cctcccagca gggaggaact gactaaaaac caggtcagcc tcacctgtct ggtgaagggc     1200

ttctaccctt ccgacatcgt cgtggagtgg gaaagttcag gccagccaga gaatacctac     1260

aagactaccc cacccgtgct ggactctgat ggaagttatt tcctctacag caaactgaca     1320

gtggataagt ccagatggca gcagggcaac gtctttagtt gctcagtgat gcatgaggcc     1380

ctccacaatc attacacaca gaaaagcctg tccgtgtctc cccggggcag gaagaggaga     1440

agtggatcag gcgcaactaa cttcagcctg ctcaagcagg caggggacgt ggaggaaaat     1500

cccggaccta tggtcctgca gacccaggtg tttatctccc tgctcctgtg gatttctggc     1560

gcatacgggg ccatccagat gacacagagc cccagctccc tgagcgcctc cgtcggcgac     1620

cgggtgacta tcacctgtcg cgctagccag ggaattagga acgatctggg ctggtatcag     1680

cagaagcccg gcaaagcccc taagctcctg atctactctg ctagtacact gcagtccggg     1740

gtgccttcta ggttctcagg gagcggcagc ggcactgact tcaccctcac tatttctagt     1800

ctgcagccag aggacttcgc aacctattac tgcctgcagg attataatta cccctggaca     1860

tttgggcagg gaactaaagt ggagatcaag cgcgctgtcg ctgcacctag cgtgttcatc     1920

tttcctccaa gtgaagacca ggtcaagagt ggcaccgtgt cagtggtgtg cctcctgaac     1980

aatttctatc caagggaggc ctccgtgaag tggaaagtcg atggggtgct gaaaacagga     2040

aactcacagg agagcgtgac tgaacaggac agtaaggata atacctactc actgtcaagc     2100

accctcacac tgtcctctac cgactatcag tctcacaacg tgtacgcttg cgaagtcacc     2160

caccaggggc tcagtagtcc agtcacaaaa tctttcaata gaggcgaatg ttgataa        2217


<210>  33
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9247: V2L2 with Rhesus Fc in pGX0001; 
       DMAb-?PcrV operably linked to an IgE leader sequence

<400>  33

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Arg Ser 
145                 150                 155                 160 


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Val Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
225                 230                 235                 240 


Val Glu Ile Lys Thr Cys Gly Gly Gly Ser Lys Pro Pro Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Asp Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asn Gly Ala Glu Val His His Ala Gln Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Thr Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Thr His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Thr Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Gln Lys Thr Ile Ser Lys Asp 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Val Val Glu Trp Glu Ser Ser Gly Gln Pro 
                405                 410                 415     


Glu Asn Thr Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Tyr Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Val Ser Pro Arg Gly Arg Lys Arg Arg 
465                 470                 475                 480 


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                485                 490                 495     


Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile 
            500                 505                 510         


Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr 
        515                 520                 525             


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
    530                 535                 540                 


Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln 
545                 550                 555                 560 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr 
                565                 570                 575     


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            580                 585                 590         


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
        595                 600                 605             


Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly 
    610                 615                 620                 


Thr Lys Val Glu Ile Lys Arg Ala Val Ala Ala Pro Ser Val Phe Ile 
625                 630                 635                 640 


Phe Pro Pro Ser Glu Asp Gln Val Lys Ser Gly Thr Val Ser Val Val 
                645                 650                 655     


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Ser Val Lys Trp Lys 
            660                 665                 670         


Val Asp Gly Val Leu Lys Thr Gly Asn Ser Gln Glu Ser Val Thr Glu 
        675                 680                 685             


Gln Asp Ser Lys Asp Asn Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
    690                 695                 700                 


Ser Ser Thr Asp Tyr Gln Ser His Asn Val Tyr Ala Cys Glu Val Thr 
705                 710                 715                 720 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
                725                 730                 735     


Cys 
    


<210>  34
<211>  2184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9248: Pseudo-V2L2MD rbFc; DMAb-?PcrV 
       operably linked to a sequence encoding an IgE leader sequence

<400>  34
atggactgga catggagaat cctgtttctg gtcgccgccg ccaccggaac ccacgccgaa       60

gtgcagctgc tggaatctgg agggggcctg gtgcagcccg gcggcagcct gaggctgtcc      120

tgcgccgcca gcggcttcac cttctccagc tacgccatga actgggtgcg ccaggcccca      180

ggcaagggac tggagtgggt gtccgccatc accatgagcg gcatcaccgc ctactacacc      240

gacgacgtga agggccgctt caccatctcc cgggacaaca gcaagaacac cctgtacctg      300

cagatgaact ccctgagggc cgaggacacc gccgtgtact actgcgccaa ggaggagttc      360

ctgccaggaa cccactacta ctacggaatg gacgtgtggg gacagggaac caccgtgacc      420

gtgtccagcg gccagcccaa ggcccccagc gtgttcccac tggccccatg ctgcggcgac      480

accccctcca gcaccgtgac cctgggatgc ctggtgaagg gatacctgcc agagccagtg      540

accgtgacct ggaactccgg caccctgacc aacggcgtga ggaccttccc aagcgtgcgc      600

cagtccagcg gactgtactc cctgtccagc gtggtgagcg tgacctccag ctcccagcca      660

gtgacctgca acgtggccca cccagccacc aacaccaagg tggacaagac cgtggcccca      720

agcacctgct ccaagccaac ctgccctcct cccgagctgc tgggcggccc ctccgtgttc      780

atcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga ggtgacctgc      840

gtggtggtgg acgtgagcca ggacgacccc gaggtgcagt tcacctggta catcaacaac      900

gagcaggtgc ggaccgcccg ccctcccctg cgcgagcagc agttcaactc caccatccgg      960

gtggtgagca ccctgccaat cacccaccag gactggctga ggggcaagga gttcaagtgc     1020

aaggtgcaca acaaggccct gcccgccccc atcgagaaga ccatcagcaa ggccaggggc     1080

cagccactgg agcccaaggt gtacaccatg ggccctcccc gcgaggagct gagctccagg     1140

agcgtgtccc tgacctgcat gatcaacggc ttctacccca gcgacatctc cgtggagtgg     1200

gagaagaacg gcaaggccga ggacaactac aagaccaccc cagccgtgct ggacagcgac     1260

ggctcctact tcctgtacaa caagctgtcc gtgcccacca gcgagtggca gcggggcgac     1320

gtgttcacct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcatc     1380

tccaggagcc ccggcaagag gggaaggaag cgccggtccg gcagcggagc caccaacttc     1440

agcctgctga agcaggccgg cgacgtggag gagaacccag gaccaatggt gctgcagacc     1500

caggtgttca tctccctgct gctgtggatc agcggagcct acggagccat ccagatgacc     1560

cagtccccca gctccctgtc cgccagcgtg ggcgacaggg tgaccatcac ctgcagggcc     1620

agccagggca tcaggaacga cctgggctgg taccagcaga agcccggcaa ggcccccaag     1680

ctgctgatct actccgccag caccctgcag tccggagtgc ccagccggtt ctccggcagc     1740

ggctccggaa ccgacttcac cctgaccatc agctccctgc agcccgagga cttcgccacc     1800

tactactgcc tgcaggacta caactacccc tggaccttcg gccagggcac caaggtggag     1860

atcaagaggc agccagccgt gaccccatcc gtgatcctgt tccctccctc ctccgaggag     1920

ctgaaggaca acaaggccac cctggtgtgc ctgatctccg acttctaccc ccgcaccgtg     1980

aaggtgaact ggaaggccga cggaaacagc gtgacccagg gagtggacac cacccagcca     2040

agcaagcagt ccaacaacaa gtacgccgcc agctccttcc tgcacctgac cgccaaccag     2100

tggaagagct accagtccgt gacctgtcag gtcacccacg aagggcacac cgtcgaaaaa     2160

tctctggccc ccgccgaatg ttct                                            2184


<210>  35
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9248: Pseudo-V2L2MD rbFc; DMAb-?PcrV 
       operably linked to an IgE leader sequence

<400>  35

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp 
145                 150                 155                 160 


Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu 
                165                 170                 175     


Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly 
            180                 185                 190         


Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn 
    210                 215                 220                 


Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro 
225                 230                 235                 240 


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
        275                 280                 285             


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
    290                 295                 300                 


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
305                 310                 315                 320 


Val Val Ser Thr Leu Pro Ile Thr His Gln Asp Trp Leu Arg Gly Lys 
                325                 330                 335     


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
        355                 360                 365             


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
    370                 375                 380                 


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
385                 390                 395                 400 


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Asn Lys Leu Ser Val Pro 
            420                 425                 430         


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
    450                 455                 460                 


Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe 
465                 470                 475                 480 


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
                485                 490                 495     


Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly 
            500                 505                 510         


Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
        515                 520                 525             


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile 
    530                 535                 540                 


Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            580                 585                 590         


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn 
        595                 600                 605             


Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gln 
    610                 615                 620                 


Pro Ala Val Thr Pro Ser Val Ile Leu Phe Pro Pro Ser Ser Glu Glu 
625                 630                 635                 640 


Leu Lys Asp Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
                645                 650                 655     


Pro Arg Thr Val Lys Val Asn Trp Lys Ala Asp Gly Asn Ser Val Thr 
            660                 665                 670         


Gln Gly Val Asp Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
        675                 680                 685             


Ala Ala Ser Ser Phe Leu His Leu Thr Ala Asn Gln Trp Lys Ser Tyr 
    690                 695                 700                 


Gln Ser Val Thr Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys 
705                 710                 715                 720 


Ser Leu Ala Pro Ala Glu Cys Ser 
                725             


<210>  36
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9257 heavy chain: Pseudo-V2L2MD in 
       pGX0003 (sCMV-light chain, hCMV-heavy chain); DMAb-?PcrV operably
       linked to a sequence encoding an IgE leader sequence

<400>  36
atggattgga catggaggat tctgtttctg gtcgccgccg ctactggaac ccacgccgag       60

gtgcagctgc tggagtcagg aggaggactg gtgcagcccg gcggatcact gcgactgagc      120

tgcgcagctt ccggcttcac cttcagcagc tatgccatga actgggtccg acaggctcct      180

ggcaagggac tggaatgggt gagtgcaatc accatgtcag ggattactgc ctactatacc      240

gacgatgtga aaggccgatt cactatctct agggacaaca gtaagaatac cctgtacctg      300

cagatgaatt ccctgcgcgc tgaggataca gcagtgtact attgcgccaa ggaggaattc      360

ctgccaggga ctcactacta ttacggaatg gacgtgtggg gacagggaac cacagtcacc      420

gtgtctagtg caagcacaaa aggcccctcc gtgtttcccc tggccccttc aagcaagtct      480

acaagtgggg gcactgcagc cctgggatgt ctggtgaagg attacttccc tgagccagtc      540

accgtgagct ggaactccgg cgccctgact tccggagtcc atacctttcc tgctgtgctg      600

cagtcctctg gcctgtatag cctgagttca gtggtcaccg tcccaagctc ctctctggga      660

acacagactt acatctgcaa cgtgaatcac aaaccaagca atacaaaggt cgacaagaaa      720

gtggaaccca aatcctgtga taagacccat acatgccctc cctgtccagc acctgagctg      780

ctgggagggc caagcgtgtt cctgtttcca cccaagccta aagacacact gatgatttct      840

cggacccccg aagtcacatg cgtggtcgtg gacgtgagcc acgaggaccc cgaagtcaag      900

tttaactggt acgtggatgg cgtcgaggtg cataatgcca agaccaaacc acgagaggaa      960

cagtataact ctacatacag ggtcgtgagt gtcctgactg tgctgcacca ggactggctg     1020

aacgggaagg agtacaagtg caaagtgtcc aacaaggccc tgccagctcc catcgagaag     1080

accatttcta aggccaaagg ccagccaaga gaaccccagg tgtatacact gcctccaagt     1140

cgggacgagc tgactaaaaa ccaggtctct ctgacctgtc tggtgaaggg attctaccct     1200

tccgatatcg ctgtggagtg ggaatctaat gggcagccag aaaacaatta taagactacc     1260

cctcccgtgc tggactctga tggaagtttc tttctgtact ccaaactgac cgtggacaag     1320

tctagatggc agcaggggaa cgtcttttca tgcagcgtga tgcatgaggc cctgcacaat     1380

cattacactc agaaatccct gtctctgagt cctgggaaa                            1419


<210>  37
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9257 heavy chain: Pseudo-V2L2MD in 
       pGX0003 (sCMV-light chain, hCMV-heavy chain); DMAb-?PcrV operably
       linked to an IgE leader sequence

<400>  37

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  38
<211>  2208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9258: Psuedo-V2L2MD-YTE only in 
       pGX0001; DMAb-?PcrV operably linked to a sequence encoding an IgE
       leader sequence

<400>  38
atggattgga catggaggat tctgtttctg gtcgccgccg ctactggaac ccacgccgag       60

gtgcagctgc tggagtcagg aggaggactg gtgcagcccg gcggatcact gcgactgagc      120

tgcgcagctt ccggcttcac cttcagcagc tatgccatga actgggtccg acaggctcct      180

ggcaagggac tggaatgggt gagtgcaatc accatgtcag ggattactgc ctactatacc      240

gacgatgtga aaggccgatt cactatctct agggacaaca gtaagaatac cctgtacctg      300

cagatgaatt ccctgcgcgc tgaggataca gcagtgtact attgcgccaa ggaggaattc      360

ctgccaggga ctcactacta ttacggaatg gacgtgtggg gacagggaac cacagtcacc      420

gtgtctagtg caagcacaaa aggcccctcc gtgtttcccc tggccccttc aagcaagtct      480

acaagtgggg gcactgcagc cctgggatgt ctggtgaagg attacttccc tgagccagtc      540

accgtgagct ggaactccgg cgccctgact tccggagtcc atacctttcc tgctgtgctg      600

cagtcctctg gcctgtatag cctgagttca gtggtcaccg tcccaagctc ctctctggga      660

acacagactt acatctgcaa cgtgaatcac aaaccaagca atacaaaggt cgacaagaaa      720

gtggaaccca aatcctgtga taagacccat acatgccctc cctgtccagc acctgagctg      780

ctgggagggc caagcgtgtt cctgtttcca cccaagccta aagacacact gtacattact      840

cgggagcccg aagtcacatg cgtggtcgtg gacgtgagcc acgaggaccc cgaagtcaag      900

tttaactggt acgtggatgg cgtcgaggtg cataatgcca agaccaaacc acgagaggaa      960

cagtataact ctacatacag ggtcgtgagt gtcctgactg tgctgcacca ggactggctg     1020

aacgggaagg agtacaagtg caaagtgtcc aacaaggccc tgccagctcc catcgagaag     1080

accatttcta aggccaaagg ccagccaaga gaaccccagg tgtatacact gcctccaagt     1140

cgggacgagc tgactaaaaa ccaggtctct ctgacctgtc tggtgaaggg attctaccct     1200

tccgatatcg ctgtggagtg ggaatctaat gggcagccag aaaacaatta taagactacc     1260

cctcccgtgc tggactctga tggaagtttc tttctgtact ccaaactgac cgtggacaag     1320

tctagatggc agcaggggaa cgtcttttca tgcagcgtga tgcatgaggc cctgcacaat     1380

cattacactc agaaatccct gtctctgagt cctgggaaac ggggccgcaa gaggagatca     1440

ggaagcgggg ccaccaactt ctccctgctg aagcaggctg gcgatgtgga ggaaaatcct     1500

ggaccaatgg tcctgcagac tcaggtgttt atctcactgc tgctgtggat tagcggagca     1560

tacggggcca ttcagatgac ccagtccccc agttcactgt ccgcttctgt cggcgacaga     1620

gtgactatca cctgtcgggc aagccaggga attcgcaacg atctggggtg gtatcagcag     1680

aagcctggga aagctccaaa gctgctgatc tacagtgcat caactctgca gtcaggagtg     1740

cctagccggt tcagcggctc cggatctgga accgacttta cactgactat tagctccctg     1800

cagccagagg acttcgccac atattactgc ctgcaggatt ataattaccc ctggacattt     1860

ggccagggaa ctaaagtgga aatcaagcgc acagtcgctg cacctagcgt gttcatcttt     1920

ccaccctcag acgagcagct gaagtccgga actgcttctg tggtgtgcct gctgaacaat     1980

ttctatccaa gggaagcaaa agtccagtgg aaggtggata acgccctgca gtcaggcaat     2040

agccaggagt ccgtgaccga acaggactct aaagatagta catacagtct gtcaaacacc     2100

ctgacactga gcaaggctga ttatgagaag cacaaagtgt acgcatgcga agtcacccac     2160

caggggctgt cctcaccagt cacaaaatct ttcaatcggg gagaatgc                  2208


<210>  39
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9258: Psuedo-V2L2MD-YTE only in 
       pGX0001; DMAb-?PcrV operably linked to an IgE leader sequence

<400>  39

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln 
        515                 520                 525             


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
    530                 535                 540                 


Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln 
545                 550                 555                 560 


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu 
                565                 570                 575     


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            580                 585                 590         


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
        595                 600                 605             


Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr 
    610                 615                 620                 


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
625                 630                 635                 640 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
                645                 650                 655     


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
            660                 665                 670         


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
        675                 680                 685             


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser 
    690                 695                 700                 


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
705                 710                 715                 720 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730                 735     


<210>  40
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9257 light chain: Pseudo-V2L2MD in 
       pGX0003 (sCMV-light chain, hCMV-heavy chain); DMAb-?PcrV operably
       linked to a sequence encoding an IgE leader sequence

<400>  40
atggtcctgc agactcaggt gtttatctca ctgctgctgt ggattagcgg agcatacggg       60

gccattcaga tgacccagtc ccccagttca ctgtccgctt ctgtcggcga cagagtgact      120

atcacctgtc gggcaagcca gggaattcgc aacgatctgg ggtggtatca gcagaagcct      180

gggaaagctc caaagctgct gatctacagt gcatcaactc tgcagtcagg agtgcctagc      240

cggttcagcg gctccggatc tggaaccgac tttacactga ctattagctc cctgcagcca      300

gaggacttcg ccacatatta ctgcctgcag gattataatt acccctggac atttggccag      360

ggaactaaag tggaaatcaa gcgcacagtc gctgcaccta gcgtgttcat ctttccaccc      420

tcagacgagc agctgaagtc cggaactgct tctgtggtgt gcctgctgaa caatttctat      480

ccaagggaag caaaagtcca gtggaaggtg gataacgccc tgcagtcagg caatagccag      540

gagtccgtga ccgaacagga ctctaaagat agtacataca gtctgtcaaa caccctgaca      600

ctgagcaagg ctgattatga gaagcacaaa gtgtacgcat gcgaagtcac ccaccagggg      660

ctgtcctcac cagtcacaaa atctttcaat cggggagaat gc                         702


<210>  41
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9257 light chain: Pseudo-V2L2MD in 
       pGX0003 (sCMV-light chain, hCMV-heavy chain); DMAb-?PcrV operably
       linked to an IgE leader sequence

<400>  41

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
            100                 105                 110         


Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  42
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9213: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096); DMAb-BiSPA operably linked to a sequence 
       encoding an IgE leader sequence

<400>  42
atggactgga catggagaat cctgtttctg gtcgccgccg caactggaac ccacgccgaa       60

gtgcagctgc tggagtcagg gggagggctg gtgcagcccg gcggcagcct gcgactgtct      120

tgcgccgcta gtggcttcac cttcagcagc tatgctatga actgggtccg acaggcacca      180

ggaaagggac tggaatgggt gtctgccatc accatgagtg gaattacagc ttactatact      240

gacgatgtga aggggagatt cacaatctca cgggacaaca gcaaaaatac tctgtacctg      300

cagatgaata gcctgagggc agaggatacc gccgtgtact attgcgccaa ggaggaattc      360

ctgcctggca cacactacta ttacggaatg gacgtgtggg gccagggaac cacagtcacc      420

gtgtctagtg cttcaacaaa ggggccaagc gtgtttccac tggcaccctc aagcaaatca      480

accagcgggg gcacagcagc cctgggatgt ctggtgaagg attacttccc cgagcctgtc      540

accgtgtcat ggaacagcgg agccctgacc tccggagtcc acacatttcc tgctgtgctg      600

cagtcctctg ggctgtattc tctgagttca gtggtcacag tcccaagctc ctctctgggc      660

acacagactt acatctgcaa cgtgaatcat aagccatcca atactaaggt cgacaaacgg      720

gtggagccca aatcttgtgg cggcggcggc agcggcggcg gcggcagcca ggtccagctg      780

caggagagcg gacctggact ggtgaagcca tccgaaacac tgtctctgac ctgcaccgtg      840

agcggcggca gcatctctcc atattactgg acttggatta ggcagccccc tggcaagtgt      900

ctggagctga tcgggtacat tcacagttca ggctataccg actacaaccc ctccctgaag      960

tctagagtga ctatcagtgg cgatacctca aagaaacagt tctccctgaa actgagctcc     1020

gtcactgctg cagacaccgc cgtgtattac tgcgcacgcg ccgactggga tcgactgcgc     1080

gctctggata tctggggaca ggggactatg gtcaccgtgt ctagtggggg cggagggagt     1140

ggcggagggg gctcaggagg gggcggaagc gggggcggag ggtccgacat tcagctgacc     1200

cagagcccct caagcctgag tgcctcagtc ggcgatcgcg tgactatcac ctgtcgagct     1260

agccagtcca ttaggtccca tctgaactgg tatcagcaga agcccggaaa agcacctaag     1320

ctgctgatct acggcgccag caatctgcag tccggagtgc cctctaggtt ctctggcagt     1380

ggatcaggga cagactttac actgactatt tcctctctgc agcctgagga tttcgcaact     1440

tattactgcc agcagagcac cggcgcctgg aactggtttg gctgtggaac caaggtggaa     1500

atcaaaggcg gagggggctc tggagggggc ggaagtgaca agacccacac atgcccaccc     1560

tgtccagcac cagagctgct gggcggccca tccgtgttcc tgtttcctcc aaagcctaaa     1620

gatacactga tgattagcag aacacccgaa gtcacttgcg tggtcgtgga cgtgtcccac     1680

gaggaccccg aagtcaagtt taactggtac gtggacggcg tcgaggtgca taatgccaag     1740

accaaacccc gagaggaaca gtataactca acctacaggg tcgtgagcgt cctgacagtg     1800

ctgcatcagg attggctgaa cggcaaggag tacaagtgca aagtgtctaa taaggctctg     1860

cctgcaccaa tcgagaaaac tattagcaag gccaaaggcc agcctagaga accacaggtg     1920

tataccctgc ccccttctcg ggaggaaatg acaaagaacc aggtcagcct gacttgtctg     1980

gtgaaaggct tctacccttc tgacatcgct gtggagtggg aaagtaatgg acagccagaa     2040

aacaattata agactacccc acccgtcctg gacagtgatg gctcattctt tctgtacagt     2100

aagctgaccg tggataaatc aaggtggcag cagggaaacg tctttagctg ctccgtgatg     2160

cacgaggccc tgcacaatca ttacacacag aagtctctga gtctgtcacc tggcaagcga     2220

ggaaggaaaa ggagaagcgg gtccggagca accaacttca gcctgctgaa acaggctggg     2280

gacgtggagg aaaatcccgg ccctatggtc ctgcagaccc aggtgtttat ctccctgctg     2340

ctgtggattt ctggggccta cggcgctatc cagatgacac agtctcctag ttcactgtct     2400

gcaagtgtcg gcgacagagt gactatcacc tgtcgggctt cccagggaat tcgcaacgat     2460

ctggggtggt atcagcagaa accaggaaag gctcccaaac tgctgatcta ctcagcaagc     2520

acactgcaga gtggggtgcc atcaagattc tccggatctg ggagtggcac tgacttcacc     2580

ctgactatta gctccctgca gccagaggac ttcgccacct attactgcct gcaggattat     2640

aattacccct ggacatttgg acaggggact aaggtggaga tcaaacggac tgtcgccgct     2700

cccagcgtgt tcatttttcc tccatccgac gaacagctga agagcggaac cgcatccgtg     2760

gtgtgcctgc tgaacaattt ctatcctcgc gaagcaaagg tccagtggaa agtggataac     2820

gccctgcaga gcggcaattc ccaggagtct gtgactgaac aggacagtaa ggattcaacc     2880

tacagcctgt ctagtaccct gacactgtcc aaagctgact atgagaagca taaagtgtac     2940

gcatgtgagg tcacccacca ggggctgtcc agtccagtca ccaagtcttt caataggggc     3000

gaatgc                                                                3006


<210>  43
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9213: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096); DMAb-BiSPA operably linked to an IgE 
       leader sequence

<400>  43

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
            260                 265                 270         


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Pro Tyr 
        275                 280                 285             


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile 
    290                 295                 300                 


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
305                 310                 315                 320 


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
                325                 330                 335     


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Ala Asp Trp Asp Arg Leu Arg Ala Leu Asp Ile Trp Gly Gln Gly 
        355                 360                 365             


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
        435                 440                 445             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Ser Thr Gly Ala Trp Asn Trp Phe Gly Cys Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        515                 520                 525             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    530                 535                 540                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
545                 550                 555                 560 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                565                 570                 575     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            580                 585                 590         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        595                 600                 605             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    610                 615                 620                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
625                 630                 635                 640 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                645                 650                 655     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            660                 665                 670         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        675                 680                 685             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    690                 695                 700                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
705                 710                 715                 720 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                725                 730                 735     


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
            740                 745                 750         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        755                 760                 765             


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
    770                 775                 780                 


Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
785                 790                 795                 800 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
                805                 810                 815     


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            820                 825                 830         


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
        835                 840                 845             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    850                 855                 860                 


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
865                 870                 875                 880 


Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
                885                 890                 895     


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
            900                 905                 910         


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
        915                 920                 925             


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
    930                 935                 940                 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
945                 950                 955                 960 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
                965                 970                 975     


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
            980                 985                 990         


Val Thr Lys Ser Phe Asn Arg Gly  Glu Cys 
        995                 1000         


<210>  44
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9215: Pseudo-Ps10096; DMAb-?Psl 
       operably linked to a sequence encoding an IgE leader sequence

<400>  44
atggattgga catggaggat tctgtttctg gtggccgccg ctactggaac ccacgctcag       60

gtgcagctgc aggagtctgg acccggactg gtcaagccta gcgaaactct gtccctgact      120

tgcaccgtgt ccggcggatc aatcagccca tactattgga cctggattcg ccagccccct      180

ggcaagggac tggagctgat cggctacatt cacagctccg gatacaccga ctataaccca      240

tcactgaaaa gccgagtgac aatctctggc gatactagta agaaacagtt cagcctgaag      300

ctgtctagtg tcacagccgc tgacactgca gtgtactatt gcgcccgcgc tgactgggat      360

cgactgcgcg ctctggatat ttgggggcag ggcactatgg tcaccgtgag cagcgcctca      420

accaaaggcc ctagcgtgtt tccactggca ccctcctcta agtccacctc tgggggcaca      480

gcagccctgg gatgtctggt gaaggactac ttccccgagc ctgtcacagt gtcctggaac      540

tctggagccc tgacctccgg ggtccataca tttcccgctg tgctgcagag ttcagggctg      600

tactctctga gctccgtggt caccgtgcct tctagttcac tgggcacaca gacttatatc      660

tgcaacgtga atcacaaacc ttccaataca aaggtcgaca agaaagtgga accaaaatct      720

tgtgataaga cccatacatg cccaccctgt ccagcaccag agctgctggg agggccatcc      780

gtgttcctgt ttcctccaaa gcccaaagac accctgatga ttagccggac tccagaagtc      840

acctgcgtgg tcgtggacgt gtcccacgag gaccccgaag tcaagttcaa ctggtacgtg      900

gatggcgtcg aggtgcataa tgccaagaca aaaccccgag aggaacagta caactccact      960

tatagggtcg tgtctgtcct gaccgtgctg caccaggatt ggctgaacgg gaaggagtat     1020

aagtgcaaag tgtctaacaa ggccctgcct gccccaatcg agaagaccat tagcaaggcc     1080

aaaggccagc ctagagaacc acaggtgtac acactgcccc ctagtcggga cgagctgact     1140

aaaaaccagg tcagcctgac ctgtctggtg aagggcttct atccctcaga tatcgctgtg     1200

gagtgggaat ctaatggaca gcctgaaaac aattacaaga ccacaccacc cgtgctggac     1260

agtgatggat cattctttct gtatagcaaa ctgaccgtgg acaagtccag atggcagcag     1320

gggaacgtct ttagttgctc agtgatgcac gaggccctgc acaatcatta cactcagaaa     1380

agcctgtccc tgtctcccgg caaacgagga aggaagagga gaagtggatc aggggccaca     1440

aacttcagcc tgctgaagca ggctggggat gtggaggaaa atcccggccc tatggtcctg     1500

cagacacagg tgtttatcag tctgctgctg tggatttcag gggcctatgg cgacatccag     1560

ctgactcagt cccctagctc cctgagcgcc tccgtcggag atagagtgac tatcacctgt     1620

cgggcttctc agagtattcg cagccatctg aactggtacc agcagaagcc cgggaaagct     1680

cctaagctgc tgatctatgg agcatcaaat ctgcagagcg gagtgccatc ccggttctca     1740

ggcagcggca gcggaaccga ctttacactg actatttcta gtctgcagcc cgaggatttc     1800

gcaacatact attgccagca gtccactggc gcctggaact ggtttggcgg agggaccaaa     1860

gtggaaatca agcgcacagt cgctgcacct agcgtgttca tctttcctcc aagtgacgag     1920

cagctgaagt ctggcaccgc cagtgtggtg tgcctgctga acaatttcta cccaagggaa     1980

gcaaaagtcc agtggaaggt ggataacgcc ctgcagagcg gaaattccca ggagtctgtg     2040

acagaacagg acagtaagga ttcaacttac tctctgagta acaccctgac actgagcaag     2100

gctgactacg agaagcacaa agtgtatgca tgcgaggtca cccaccaggg gctgtccagt     2160

ccagtcacta agtccttcaa taggggagaa tgc                                  2193


<210>  45
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9215: Pseudo-Ps10096; DMAb-?Psl 
       operably linked to an IgE leader sequence

<400>  45

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile 
        35                  40                  45              


Ser Pro Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Leu Ile Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln 
                85                  90                  95      


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Ala Asp Trp Asp Arg Leu Arg Ala Leu Asp Ile Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
465                 470                 475                 480 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                485                 490                 495     


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
            500                 505                 510         


Ser Gly Ala Tyr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
        515                 520                 525             


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
    530                 535                 540                 


Ser Ile Arg Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
545                 550                 555                 560 


Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro 
                565                 570                 575     


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
            580                 585                 590         


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser 
        595                 600                 605             


Thr Gly Ala Trp Asn Trp Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Asn Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  46
<211>  3006
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of pGX9259: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096)-YTE only pGX0001; DMAb-BiSPA operably 
       linked to a sequence encoding an IgE leader sequence

<400>  46
atggactgga catggagaat cctgtttctg gtcgccgccg caactggaac ccacgccgaa       60

gtgcagctgc tggagtcagg gggagggctg gtgcagcccg gcggcagcct gcgactgtct      120

tgcgccgcta gtggcttcac cttcagcagc tatgctatga actgggtccg acaggcacca      180

ggaaagggac tggaatgggt gtctgccatc accatgagtg gaattacagc ttactatact      240

gacgatgtga aggggagatt cacaatctca cgggacaaca gcaaaaatac tctgtacctg      300

cagatgaata gcctgagggc agaggatacc gccgtgtact attgcgccaa ggaggaattc      360

ctgcctggca cacactacta ttacggaatg gacgtgtggg gccagggaac cacagtcacc      420

gtgtctagtg cttcaacaaa ggggccaagc gtgtttccac tggcaccctc aagcaaatca      480

accagcgggg gcacagcagc cctgggatgt ctggtgaagg attacttccc cgagcctgtc      540

accgtgtcat ggaacagcgg agccctgacc tccggagtcc acacatttcc tgctgtgctg      600

cagtcctctg ggctgtattc tctgagttca gtggtcacag tcccaagctc ctctctgggc      660

acacagactt acatctgcaa cgtgaatcat aagccatcca atactaaggt cgacaaacgg      720

gtggagccca aatcttgtgg cggcggcggc agcggcggcg gcggcagcca ggtccagctg      780

caggagagcg gacctggact ggtgaagcca tccgaaacac tgtctctgac ctgcaccgtg      840

agcggcggca gcatctctcc atattactgg acttggatta ggcagccccc tggcaagtgt      900

ctggagctga tcgggtacat tcacagttca ggctataccg actacaaccc ctccctgaag      960

tctagagtga ctatcagtgg cgatacctca aagaaacagt tctccctgaa actgagctcc     1020

gtcactgctg cagacaccgc cgtgtattac tgcgcacgcg ccgactggga tcgactgcgc     1080

gctctggata tctggggaca ggggactatg gtcaccgtgt ctagtggggg cggagggagt     1140

ggcggagggg gctcaggagg gggcggaagc gggggcggag ggtccgacat tcagctgacc     1200

cagagcccct caagcctgag tgcctcagtc ggcgatcgcg tgactatcac ctgtcgagct     1260

agccagtcca ttaggtccca tctgaactgg tatcagcaga agcccggaaa agcacctaag     1320

ctgctgatct acggcgccag caatctgcag tccggagtgc cctctaggtt ctctggcagt     1380

ggatcaggga cagactttac actgactatt tcctctctgc agcctgagga tttcgcaact     1440

tattactgcc agcagagcac cggcgcctgg aactggtttg gctgtggaac caaggtggaa     1500

atcaaaggcg gagggggctc tggagggggc ggaagtgaca agacccacac atgcccaccc     1560

tgtccagcac cagagctgct gggcggccca tccgtgttcc tgtttcctcc aaagcctaaa     1620

gatacactgt atattactag agagcccgaa gtcacttgcg tggtcgtgga cgtgtcccac     1680

gaggaccccg aagtcaagtt taactggtac gtggacggcg tcgaggtgca taatgccaag     1740

accaaacccc gagaggaaca gtataactca acctacaggg tcgtgagcgt cctgacagtg     1800

ctgcatcagg attggctgaa cggcaaggag tacaagtgca aagtgtctaa taaggctctg     1860

cctgcaccaa tcgagaaaac tattagcaag gccaaaggcc agcctagaga accacaggtg     1920

tataccctgc ccccttctcg ggaggaaatg acaaagaacc aggtcagcct gacttgtctg     1980

gtgaaaggct tctacccttc tgacatcgct gtggagtggg aaagtaatgg acagccagaa     2040

aacaattata agactacccc acccgtcctg gacagtgatg gctcattctt tctgtacagt     2100

aagctgaccg tggataaatc aaggtggcag cagggaaacg tctttagctg ctccgtgatg     2160

cacgaggccc tgcacaatca ttacacacag aagtctctga gtctgtcacc tggcaagcga     2220

ggaaggaaaa ggagaagcgg gtccggagca accaacttca gcctgctgaa acaggctggg     2280

gacgtggagg aaaatcccgg ccctatggtc ctgcagaccc aggtgtttat ctccctgctg     2340

ctgtggattt ctggggccta cggcgctatc cagatgacac agtctcctag ttcactgtct     2400

gcaagtgtcg gcgacagagt gactatcacc tgtcgggctt cccagggaat tcgcaacgat     2460

ctggggtggt atcagcagaa accaggaaag gctcccaaac tgctgatcta ctcagcaagc     2520

acactgcaga gtggggtgcc atcaagattc tccggatctg ggagtggcac tgacttcacc     2580

ctgactatta gctccctgca gccagaggac ttcgccacct attactgcct gcaggattat     2640

aattacccct ggacatttgg acaggggact aaggtggaga tcaaacggac tgtcgccgct     2700

cccagcgtgt tcatttttcc tccatccgac gaacagctga agagcggaac cgcatccgtg     2760

gtgtgcctgc tgaacaattt ctatcctcgc gaagcaaagg tccagtggaa agtggataac     2820

gccctgcaga gcggcaattc ccaggagtct gtgactgaac aggacagtaa ggattcaacc     2880

tacagcctgt ctagtaccct gacactgtcc aaagctgact atgagaagca taaagtgtac     2940

gcatgtgagg tcacccacca ggggctgtcc agtccagtca ccaagtcttt caataggggc     3000

gaatgc                                                                3006


<210>  47
<211>  1002
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of pGX9259: Bispecific Pseudomonas 
       (Bis4-V2L2MD/Psl0096)-YTE only pGX0001; DMAb-BiSPA operably 
       linked to an IgE leader sequence

<400>  47

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Ala Ile Thr Met Ser Gly Ile Thr Ala Tyr Tyr Thr 
65                  70                  75                  80  


Asp Asp Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr 
        115                 120                 125             


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
            260                 265                 270         


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Pro Tyr 
        275                 280                 285             


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile 
    290                 295                 300                 


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
305                 310                 315                 320 


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
                325                 330                 335     


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
            340                 345                 350         


Arg Ala Asp Trp Asp Arg Leu Arg Ala Leu Asp Ile Trp Gly Gln Gly 
        355                 360                 365             


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
385                 390                 395                 400 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                405                 410                 415     


Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln 
            420                 425                 430         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
        435                 440                 445             


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    450                 455                 460                 


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
465                 470                 475                 480 


Tyr Tyr Cys Gln Gln Ser Thr Gly Ala Trp Asn Trp Phe Gly Cys Gly 
                485                 490                 495     


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        515                 520                 525             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
    530                 535                 540                 


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
545                 550                 555                 560 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                565                 570                 575     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            580                 585                 590         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        595                 600                 605             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    610                 615                 620                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
625                 630                 635                 640 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
                645                 650                 655     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            660                 665                 670         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        675                 680                 685             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    690                 695                 700                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
705                 710                 715                 720 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                725                 730                 735     


Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn 
            740                 745                 750         


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        755                 760                 765             


Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
    770                 775                 780                 


Gly Ala Tyr Gly Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
785                 790                 795                 800 


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
                805                 810                 815     


Ile Arg Asn Asp Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
            820                 825                 830         


Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
        835                 840                 845             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    850                 855                 860                 


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr 
865                 870                 875                 880 


Asn Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
                885                 890                 895     


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
            900                 905                 910         


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
        915                 920                 925             


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
    930                 935                 940                 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
945                 950                 955                 960 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
                965                 970                 975     


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
            980                 985                 990         


Val Thr Lys Ser Phe Asn Arg Gly  Glu Cys 
        995                 1000         


