                         SEQUENCE LISTING

<110>  Klinikum rechts der Isar der Technischen Universitt 
       Mnchen
       Helmholtz Zentrum Mnchen
 
<120>  A method for predicting a breast cancer patient's response to 
       anthracycline treatment

<130>  U30674WO

<150> EP 16170625.4

<151> 2016-05-20

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  26930
<212>  DNA
<213>  Homo sapiens

<400>  1
gggctcttga tgcaatctat atgccaatct acttcattag ttcttctttt atttacagtt       60

tggtaaagaa tatgggtgga gctgttctgg gctcacttgc acacatgtcc aaactgcttt      120

gaaaaaggaa gggcaagaaa gagtggtatc caagttggaa tcaggcaggc atttcagatc      180

aagagacgaa ctggaaaggg aacatctgtt agataccctg ggtttgaagg cagtctgtgt      240

aagttttcat atctctgagt gtgtgcacac agtggagagg gtggagcctg ccatcctcaa      300

atctgaaaag attgagagat ttcagagggc ccagatgtgc caaaggtcag agggatcaat      360

atacaggccc taccacggaa aggcggggaa aaggttcgaa tagaaaactg ctgcagaagg      420

gaagccactg agaggtaagg gagtttctga ataattaaaa agttaagaat aagcaaaagg      480

aaggaggtcg ggtgggggat aaaaaaaagc agttgatgtg gtaattaaga atttggtggg      540

agcctgggca ggtcacctcc tttctcagat cagagcccca tcagaaattc tttcaagtgt      600

ccttctgcgt cgccaaagat gacaacagca aatcaataag tgcttgaaat gaaaggggat      660

gttgactagc ccccaggcta cagatttccc gccgccagcc ttttctgaac tcctatagcg      720

tgcctttgca ccgcctctct taagaagagc taccttttat tcctattctc aggacgaagg      780

taagtgctca gttagcatat ctattaaatg tcagctttgg ttccagctct ccgtttgcgc      840

ggaaagctca ctgccatagc gcgcccagcc tgccggaggg gcagacagaa aaagcaagct      900

tggcctggcg acttgcgggg ccacgcacct ccagggctgg cccggagtct tccagagttt      960

aacgctcctg ggttagaact gtaaggtccc ggtccgagca aagggcctga gccaccgtag     1020

ccgtgggagc gttccttcca cttgaatgca ctcactcaca aacaagcaca aaatcttttt     1080

aacagcagag gagaaagacc cctgctccaa aattaaagct gggaatcacc ggaaactccg     1140

ttttgagtgc gagatattgg tctgttacct ttctaatctt catatccctc ctgtaatatg     1200

tcttgattta acaatctttc cagcgcccag cattgcccgg acgttttaat tgggtaattc     1260

attagtgagt caatacaggc atttatatat tcttttagct caagtggtta agtactaatt     1320

tcgaaatgat tataaaacac cggaatcggc aacgcatagt aattttaatt tatatgcaaa     1380

tcaattggtt catcttaaat gcctttttta aaaaaacaat tattgtattg tagcatcgga     1440

ggcatggatc aaacctctag aatagacaat tcggaaacaa gacctggact aggaagacaa     1500

tttagaacag ccaacaaatc aataatgttt gaggcagtta aacatcgcta gccattggta     1560

tttacatact cgcttgttgt cagataagga gctggggaaa ttgcttgcca gggttgagat     1620

cataatccag agtgaagaaa gtaaatggta gcacacagcc cgtcacagcg ggctctgaaa     1680

taatactgta cctttcccaa atcctgactc ttgggtgaca gggagttggc ggaggtcacc     1740

ccacatttgt ccacggtttt gccccaattt gatcacgaaa ttgttgttct ccctgagctt     1800

tccaatttga ttaccattct aacggttctg tcacttgtct caacatattg gggggaggag     1860

tgtaattgag attctcatta aaaattatct gaacccactt agccagcact gtttcatcta     1920

agcttagttt tatgggctgt atttaattcc ctgtgccccc cacacattaa aatcagatca     1980

tcaaaatgtc ggtaggaaag ggtgaaggaa atggtccaat gctccagttt actggaagac     2040

tattatcttt agacatagtt caaaattttg aggaaataaa aaggatatac gctttggggg     2100

gaaaatgttt taatattcta gaatgggggt attactcccc ccattccaga gaatccgcac     2160

tggagttgtt tatgtaaaaa tgtaacatcc ttgaaattca cagatacgta aggttagtgt     2220

ctccccttcc ccaggctccc agtccaggcg atctagccct aaaggagcta gtacctttga     2280

tgctacaatc ttgtttacat ctgcagggca gagaattgct tgctttgctt ggacgctccc     2340

tccaccccct tctaatttga agtaatcgga atctaaatac agtcgccaag gcccgctctt     2400

cctttactgc tttgacaagg gaaaaacctg aaatccacgt cttaaatcag ctcggtggtt     2460

tgtagccccc cagcaccctg cttctacgat tgcatgccta atgtattccc tggtgattct     2520

gggcattaat tagttgttta ataggagtat gactaaaaat gtaaaagaag gattaggagc     2580

gtgaaacgta tgtccagctc cttccacaca ctcgaggagg gaatgagaat cattctgtat     2640

cttctatttc tccaggagcc atttgcattt cccaccagct gctcacttca gctgcactgg     2700

cgctgggcaa ggcgaggacc caaaagctca gcgcagtgtc tgcggcggcc gggactgggg     2760

ttaaccagcc tctggcgggc gagactccag acagaagggg ggcgagagga acgtgagctt     2820

cccgagcccc ttcctctcag ccctggtttg caaacctctg aaacctgaaa ggggagggag     2880

ttgcacgcgc gtatctttgc gtcttttcag cgcaactccc ttccctctcc ctgtgtctct     2940

ccgcggatct ctgaatcttt ctgtctttgg ttttctcatt ctcttccaac ttttccatga     3000

gattgcctat cctcgccacc agctgaaggc aaggccgttc tgctacgagc gcctcttaat     3060

ctctacaaaa tgaaaagaaa aaaagggagg attattagcc cattactcag aggaatgggg     3120

aggctgcaaa aatcgtcgat gggcagaggt gaagatgtct ttctcggact gcactttccg     3180

gtgtcctgta actagagttc agttgtggga cttgttgaag aaatttgatt ttcttgcctc     3240

ggcgagattt caaaaaccag aaatagaaat tctcagagtc agagaggaaa tacaattaaa     3300

cagcacgtgg gcattttccc cctcatttct ctccccttaa ataacactgc tttgagtttc     3360

cactgggtaa agagagaaag tttgagtttt cacggatgtt acgtggaggt tagaaatggc     3420

ttaaaatgta gatctctaat cagttttctt cgtggctgaa gaggctaacc ctttccataa     3480

aatgagtcca tctgtcgact gttagctatt tcaaagtgaa gggatttagc actcaaaaca     3540

aattgagcaa gtttgtttgc ctgtttttac tgctaactca aatgaattca aaacacggag     3600

taattcaaga aaacacataa catgttccag acagccccca aaagtaggga aagcccagca     3660

cctatatagt gactagggtt agttttaagc gccaagcttt tttaaacgta tctattttat     3720

gcacattctc ccgagtcact atatatttct aaaattgcga gtattggtat attgatttag     3780

gaagagcaat acaactttta gagggaactt tattctcaat tagggaccaa agagatgtct     3840

ttttaatagc gggcctgagt tttgctctca agcaggaatt aatattggtg ggaaaatccg     3900

aatccaggag caatggctgt gttccggcac tttccaaaaa catacattaa caggatgccc     3960

ttgagattga aaaaacattg tcccatatgc ctggcagaag ccttcacacc tggtcctcca     4020

ggcgaattat atttatagtc cttccactca gaggcaggac agagccaaaa tattctgctc     4080

actaccaaaa tacacatctt tgctcaagtc aagaaatcag aaaatcaggg ttcagaagta     4140

aggcacactt ttcgagtgag aatatgccct gtaatttcac atactctttg ctttgcagga     4200

gcaaatgtgg acttgaggga aactctctcc cccaccccca cttctatccc gtgcaattta     4260

ataccatcct cgccaggaac cttaacctcg tcattttaaa aaatgagata tccgtgaccc     4320

agggtgaact tgttgaatgt aggtacagca gaggaaattc tagactctat gagcgtctga     4380

gccttgtcca gtgcaaaccc ttcgtgaaca ctgggtcagt gcgtggccgt gcccacctgt     4440

gcgccgacac tctcagcatg cctggtccac ccgccttgac ctcgggcgcg gtgtcccagc     4500

taagctgggc ccagcgtccc ggccttcccc agctgacaag cctagctcgt tcgctcccgg     4560

ctgtggccct cccaccctct cccactagct cactccattc ttctagattt ctcttcactc     4620

atcctctccc atccccaccg cgcccacctc cactcccgcc ctctaccggt ctctcacttt     4680

cctccctccg cagtccctct ttgctgtgac ctctttcctc aactctgcag gcctgaaaga     4740

aggtcacaca cgcacgctca cacccacact ccacacgcct cgtcccaaac aaccccatga     4800

acattgtcct ttgttccgtc tcttgggcca ctttccctgt cgcttcctcc cagcccgtcc     4860

tgatttgctc cccaaaagta cgtttctgtc tccccgctgc cctggcgctc cccctttgat     4920

ttattagggc tgccgggttg gcgcagattg ctttttcttc tcttccatcc catcctccct     4980

tctggtcctc ctttccacag tgggagtccg tgctcctgct cctcggttgg ctcctaagtg     5040

ccccgccagg tcccctctcc tttcgctctc ccggctccgg ctcccgactc ttcggcccgc     5100

tggcatctgc ttccctcccc tgcctcgttt ctcgtcgccc ctgctcgctc cccccggcgc     5160

tcgcccgggc gctgtgctcg ctcctggatc gccagccgcg cagccgggct cggccggccg     5220

cccgcgcgcc actgtgcagt ggagtttggt ggaatctctg ctgacgtcac gtcactcccc     5280

acacggagta ggagcagagg gaagagagag ggatgagagg gagggagagg agagagagtg     5340

cgagaccgag cgagaaagct ggagaggagc agaaagaaac tgccagtggc ggctagattt     5400

cggaggcccc agtgcacccg tggactcctt cggaacttgg caccctcagg agccctgcag     5460

tcctctcagg cccggctttc gggcgcttgc cgtgcagccg gaggctcggc tcgctggaaa     5520

tcgccccggg aagcagtggg acgcggagac agcagctctc tcccggtagc cggtaagtgg     5580

aggccatcta tcccgcaggg atgtgagata atgcgagtct ggaaatttgt tccacttcgg     5640

agaatcttca ccgtaggtga tttgtggctt ttggggctaa gtttcgccca aggtaacgca     5700

gtcggcaaac agaccttgca aagccctgtt cctttcgtcc cccgccacag acactaacaa     5760

tctacagggt gctgaagtcg agagggaagc cagaccgtgg ctggcattta aaacgaggta     5820

tcttccctta aatctcggtg ccaacactgc aggaacaaat cctcgggcca aggattagca     5880

ttctcaagat aaagggctgg gtacaaagtt tcagctactg gaagattagc ccccttccca     5940

ttgttatcca ttgggaaaaa aaagaaaaga aaaagattcc atcttaactg gcagttagtg     6000

acctctcagg cccaagcgaa ttacctggga gccaggcctg gatgccaagc tctcaccatt     6060

tctttggatt gtaactcctt taaattgatc accagtcaac tccaatctgg cacttcagga     6120

gatacacttt aaatggatgc agagaattat tttccagctg gagattaaga aaaaaatttt     6180

cgattctaaa cctccgaaat atgttcctct tttccagttt aaccacttta ctttcttaag     6240

caatttagaa atcaaactat cataaggtgg tgtgattttt ttttactctt ttgtgtgagt     6300

attgtcttac taaactaaac ggaaaaaact tttaccatta taaatgtaaa tatcagaatt     6360

catacattct aaaatatttt tatgaaaaat taatctgatt taaagaaatt tccttgcatt     6420

tgttttagtc tatcaatcaa aactaaagat gcttttatca cacaaaatat cattttggca     6480

gaaatccatc taaaattcaa ataccaataa tatcaagaaa acaaagcaca taagcaaaat     6540

aaattgaaga tttttgttga tgtaacatga gcatacaaca tttcaataac caaactttcc     6600

ctaaaaaatt aaatagccac ttcatttgtg gaatgtttta ctttaactca gcaaaattac     6660

acttaaatta tttaggtgct ttgttcctta agttaagcgt gtttgtcttc aaatgttcct     6720

aaagcactta tattaattgg ttgtaaagaa cgcatacaca tggtaaaata cagaactgaa     6780

ctgagcagta ttttaatttc cttaaataat tacttactac aaattaattt actggctaat     6840

ttcacaattt agttcattta aaacacatgt tcctgtgctg tttattttta aactttccat     6900

taaagatttt gttatggggt aacaaagtgt atgaaaaggg gggaaatgtg aaaggatctg     6960

ggattattcg aactgtattt ttcctgcact ttcagtcttg cggtagtcat cagaaattat     7020

tttttagcaa attgttttat ttcttagggc ttgcctgcct gctttgccat ggttcctcgt     7080

cctccgttag ccgtgtagtg ctttttgtgt gctcacaata taaaacccaa gttggccaaa     7140

acaagagtcc ttggcatata cattccaact agaacatgaa ctttgggggt gagaactacc     7200

tcccatcagg aaaagtctcc catctcaatt tgtgagatta gccattgaag ccagttccga     7260

agtctggcag ccaaatttct cacagaagac ttgtcttgat agggcaagtt taaggatcag     7320

caggcgggaa ttggaggtct ctttttaaaa aattatcttc cccagttatt tagactcagt     7380

tcttctagta ggcctggtca ttaaatgaag cataaaaatg caagtctcaa ggctcatttt     7440

gactgcaaaa taaatctcca agtcacaagg acatgtagga gtgagctaag gaacacgcct     7500

tgaccttctt ttcagtcctt agagtggagc tctatgagtt cttgaagatt tgttttgtat     7560

tgctttgttt ggtcttcagc actgaagcac ggggaagtgg ggggaagaat gtgtaataat     7620

tgactgactt tacaccaagc aacgcaatct ttttcttttg tatatttcat tctttaaaaa     7680

aaataaataa ataaaaacta tttgcagtta ccatctgcag tgctccggct accagctaat     7740

aatgcagcca gttcagacat ataaaaaaaa aagattatcg aaatgatgat gacatgcaaa     7800

tttcctccga aattatcata agtaaacatt tgaagtctgg actaataaaa tcccatctgt     7860

gttacttcat atcgagttag tagaaagctg tgataatgaa ttttgtaata tctcacgaac     7920

agacatctca atcagggact aatcctgtga ttttactgca gaatcactaa atctggagcc     7980

gccaaactgc tacttctggg cccacgggcc cacaaggatc gaatcggcag agtccccgcc     8040

cgcgttctcg ctagcgggtg ggggaaccgc ctggccgtcc ccaccctgga tccccacgcc     8100

acagcgccgg gcagcccctc ctgtaggcag cgaccttggc cagaggctcc ccagggccca     8160

gctcccttca ggagaggccg agacgcaggg aaacggtact caggccagag gcaggcccgc     8220

agctccctgc cccgcctctg tgcctccgcc aacccgacaa cgcttgctcc caccccgatc     8280

cccgcacccg cgcgaagtgg gccctccggt cgtcggcgta ccctggttag cgtggagaga     8340

ggcaggcgct gagatcgaag gggcctaggg agccctggac cttcttttct tgtctttaaa     8400

gcaaccgcgg ctcttctacc cacccggtgg agcccctcga gacccacctc tcccggcttg     8460

cctgtggcag agaaggggga gcgcgttaaa tgcttggctc gctgcgttgt ggttgaaaac     8520

gtgaaaaaga tttggctcgc ccgggagaga aagggggaga actgggtagc agttatacca     8580

gagctatttc tccgtccttg gcgggcagta aaccctccaa gaacgtttgc cctgctctcc     8640

tcagtctcgc tcagtccacc cagtgtctct cctctgcgat cttaaatcat actttagggt     8700

aattatttgt agtaagtaaa taaatggccg ggttagtatc tctaggagaa agtgtggcta     8760

aatatggaaa agtggctcct gatggatgag aggcccgaac tcagctcgct cctgaaacac     8820

cctaggccaa gagcccgttc gtttcagaat tacagaaaac cgagggaaac tgctgtctag     8880

gacaggggca cgttggcgct gatgttctac aaatgtttac cgagctccaa ctaatggaca     8940

agcactgaag ggtggtcttt gcatacagct tcccaaagag aaaagtcctc tccacccacc     9000

cactcccgct gccattgcgt tcagatgagt tcttaacccc ggcaccgaga ttcttgaaag     9060

taggtccaca gcctccccag cacactgtgg ctttatagtc ctctaacctc tgggcacttt     9120

tgcggcaact ctggagggag atcccctctt gataaataaa tgtcctgggc ccgaggctag     9180

gctggagatg ctgctgcaca gccagaggct gtcaggtcgg aaaaacacgc ctgaagccta     9240

gcacacagta ggcgcctaac agctagtgta acgtagtctc atctgagccc tgctcactcg     9300

acggccgccg cttcttacag ccttccttct cttctgtttt gcagataacg gggaatggag     9360

accaactgcc gcaaactggt gtcggcgtgt gtgcaattag gtaagaaccc ccttctcctg     9420

cccgggtcat cggacgggag gccgcgccac gtgagggcgg caagagggca ctggccctgc     9480

ggcgaggccc cagcgagggg cgcttccccg aggggccagc ctgggcagga aggaaatcag     9540

aaccaaatcg ccagtggcct ctccctgtgg cggggcggtg gactaggaag cagcggcgcg     9600

ctgtgtaccg aagcccccca gcctactcct cccggctgga accgccggca accggggagg     9660

cgcagaaaga gtacgccatc ctgccccggg ttgccagagg gtccggggga cggggatgcc     9720

gtcagctctt tcctctaact gggtctttgc tctttgtccc tctttctcct ccggcctgcc     9780

tcgcccctcc ccctcctccc gtccccggct cctttcggcc gcggtccggg acgcctctct     9840

ccgcacgtgg ggcgggcgcg cgcgtggccc aggcgtgcag ccggcggccg ttgaatgtct     9900

cttctccaaa gactccgaaa tcaaaaaggt cgagttcacg gactctcctg agagccgaaa     9960

agaggcagcc agcagcaagt tcttcccgcg gcagcatcct ggcgccaatg gtaaggccgg    10020

gagggaagcg caggccgcgc gctgggcacc cgcctccggg actctgggcc tcgggcgaag    10080

cgcaagaagg cgaggccgcc agacctgacg cgcctgctgc ttgaacttag acactccgcc    10140

tctgggtggg acgggaagca gccgtcccag ggacgttaat tcctttcccc aaattatact    10200

gcactcctga gacccaacac ctctctctcc ctctcgctcg ctccctgtgg tctgatcccc    10260

tgcgcacgct ccagcaaacc tcggcgtcta ggctggcgtg gaaaagtggt ccaacagcga    10320

cctctgtcgc tcgttatatc ccgctgcgcg cagcaccacc agggcccact cagtcactca    10380

ggctctcagc cacgccccac ccagacttgt gggtgcgcgg ttcatcgcgg gaggcaagca    10440

agggaaactt gagttggcga aggtttgctt tggctggttg ggggaggggc ggggggccga    10500

caacatccct gaagagctgg agggcagcca ctgtgcttag cagcccaggg tagaatggag    10560

gtttgcccct gtcgacgcga acctgcctga agtactggtt gccaggcctt gggttttggc    10620

gatgtcgttg cttgattggc tggtttcact ctggaggaat cgagggacat tgccagagga    10680

ggtctacagg cttatgtaaa aagttaaaaa gtctccaacc tacgccacag gcctttcctg    10740

aattgaaact tgttctatgg ggcggagggg ggggtgtaag ggatggagga gggaagatgc    10800

ctttcttttc aaatacatgg aaaaaaaccc ctcaaattta ctgttcctct attttcctgg    10860

ctccgtagta aataagtgcc tagccttagg aggctattga cctttgataa tgtgagcaga    10920

taaagccccc ccccccccac agccctcggc ccctaacccc ctctttccgg attaaagtgt    10980

aagaatacaa atgtaatatg ggatggaggg gggcgatttg ggaccccggt caaaaaaaca    11040

aaccgtatta ctaagaagaa aacaaaggtc ttgcattgga gtttccccgt gaatctgaga    11100

gaaaatgatc atttgttgaa atgaagcgtc taaagcgatc cagtgcttca cgcccggaca    11160

ctgcactaca ccgccagtcg ccctgctggg ccagttaaac gctcacttgt ccgggattaa    11220

ccccatgggg ttaaatgggg gcaatgcaga gataacgtcg cgtgatttct gtcatttaga    11280

ttgtgttaaa ttcttcttct gtttgataat cggtagtaaa aataaattat tagaccgtag    11340

tatgtttggg atatggttaa aaatcaagag cagcgatgac ttctggggag aatgctttgc    11400

gcgggctcag ccctggctcc ggccagacta gaggagctcc ccaatctcgc ttcgcgcggg    11460

gcgggctcgc agtcgccaag ccgaggctga catttcttat tgtgctggga gccagagaga    11520

cgcaaaatgt ctccttcccc cagtccctac cccaggtttc ctagacatgg ggaatgcatt    11580

ctgaggacag gtggagaagc ctacggtagg atggggtcct cgtaggtgag caggaaacgg    11640

ctaagagcag aggagttctg cttgcgccag tcacaagccg cgcaggcgcc cctggtcgtt    11700

cgcttttgat aactagcaca taaagaacta gaaataatga atgattgctt tcttaaccat    11760

tactttcagg cccgcattgt tttagtgcac gtgaaaggct cttcccctac actcaatatg    11820

tctttttcta ctttttgacc gaaaagaaaa attgctgcct aaacacgttt aatgccatta    11880

attaagaaaa ggcatgtaat gggaagaaat gctgaaaatc ttgatttaat tggcttttaa    11940

ggaactagta gacgacaaaa aaaaatcaca cgagtgggca aagctatagc actgctgaag    12000

gatagagcac ctatccttcc ctgattttaa gttaacttat ggaatatcca aagtcctggc    12060

cacagcctgc ttgtaaaaca aaaggattta tttcttgtgt ttttttaaag tttttctttg    12120

cttttaaaga gaaaaaaagt tcacaatgac atatgacttc ttcaaaaggc cgtgatagtc    12180

tattacgcta ccctctccgc ctctgccccc aacgccgccc aaaaatacca tgtcctcgtt    12240

aaagactaaa cgttctgtat aggcagagtc cacctctaag cagtccaggc tctgccttcc    12300

ttccctagtg agtcccattc tccttggtat ccattgggcg gatgcccagc ctggatagaa    12360

ccccgaaacg ggggtagcac gagagcgact ggagacccct aaaagccaga ggtttgagag    12420

agggtggacg cagctagcag aagatggtgt agaagccagc tgagaacgac cccctagagc    12480

aaagagacct ttctttggct tttcttgctt tgggggtcct gaaaggaact cataaaatgg    12540

tcttcaccct caggaggagg acggactgac cctcctctgt cactggctta aaaagtttca    12600

gggcggcggc tctgggttcc gtgctgaaat cggactgcac tgcagcccct ttggacctga    12660

cgcctggctt tgcgtcccga caaggggcgg gtacttcccc cggcctcccc caggaacgca    12720

ttaattgtta aatagctttg gcccagtgga tgggctgaaa gtgttcgacc caagtcgctg    12780

gtgtgcacag acttcctccc tctgggaggt gggctccatg gcccgttgtg gcacccccag    12840

ccgcgacaca caccttcaca cgcggcagca gctcggtccc aaccttcttc gaaggacctg    12900

ggttaaccct ggcggccttg gcggccgcag acccctctcc gccgccccgc ccccgcgcct    12960

ctcattcaat cagcgaatgt ttgcggagca tatactacgt ggactcctaa tgtaccccct    13020

gaaagcaaat aatacagttt tcctcgccgt catgaaggga ttttaatcct aacatggaca    13080

ccagcgagat cagcccagac cgtctctagc aaaacgcaaa atggtggtgc gtggggtggt    13140

gaccaaggtc ctgagccttg tcagaaagaa ggggatgtgt agagaaaggt ggagaactct    13200

agctgtggct agcgcggaag ggacaggtgc ttgccgaagg gggcatgagg cttgaggaaa    13260

aagcaacgaa ataggggtaa ggagagtttt ccattttctt tcctccgccc gacctccgcc    13320

atcccattct cccctcccct cccccacccc ccgcgccaat caaatctgca gctcacttga    13380

aaggtgcccc gccgcgttgt ggtttttcac ccccagggga aattgtacca gttgtccgaa    13440

agtagtcagt ccctgcggat ccctgcccgc aaaagtggtc ttcacaggtc gcgttcctcg    13500

ctgctgactc ggtacacaaa gtttcttaag gctggttcgg ctgttattcc tcaccgcccg    13560

ctgctaatat atgcagcagt tgttagagcg gctcggggga aaaggaaatg tataacgaaa    13620

gcttattcgt gagcaggaat atactaatgg aacaatctga tgtcttctta atcctatgta    13680

aaaagctttg tcgtcttcct aatattgact gaatgggtaa ttaatggctc ttcatctagg    13740

cgaataccct gtaatccaag ataggcaaaa gacaacaagc ccaaggtaga agacaaaagg    13800

cccaactgca gcggcgtttg cccgcctcct accccccagg gtctctgact aggaaagttt    13860

tctctcagag gagaaaaagg caggagtggg agaatatata cctatcattt cggggctaga    13920

cttcaccgca gcacctgacc acccagctca gttttctgtt actctgtctt tccacctcca    13980

gtccttctcc ctgcattttt ttttcttctt aactcctcta ggatgacctc ctaccaccac    14040

cgccattatg gtcctaataa cctttccccc taaaccccac atctttcact tcagcaacca    14100

atgaggctgt tttctgatcc aggaggagat tcttttcttt tagaacccaa tgcgtagagt    14160

ctttgagaac taaagtagtt ggtaggggag gaagaaatta atagaaaggg agagagcata    14220

cagaattgtg tgtgtatgtt aaagagcgac caggaatgac agagtcaact tctttgtgag    14280

gatctgacgg gaagagtgtc caagactcta ccagcatgtt tttaacaggc tgacatttta    14340

atttaaacct ttagaagtaa tatattactt gggttactac aatgaggtgg gttccttttt    14400

ttttgtcagc tgacagcttt taaaatatta tttcgctagg gaaataaaag cttcatctca    14460

gattataggt gggtattttt ggatttaggt gatttatggt caccatgaca actaatgctg    14520

aatgttagct accagcatgt ctgggagaga gaaaacagaa agaagggaga gcaaaagaaa    14580

tagaaaaggg agatggacat aagctggaga gggaagaaaa gagaaaaaga ggaagacaga    14640

tgagtgttta atccaactgt tgtttaaaaa agtggcgggg gggtgggact tcatttagcc    14700

ccttgccact tccttctttc ctgacctgga tatctatgct caatttcata ttccaccctt    14760

ccttcccctt ctccaaacac atgtgctata ccattctcct tattttactt agttcggcaa    14820

gtagttgctt tctggagact cagtgacacc taggaaaact gtggcagtaa catgcaaatg    14880

tgaggaagca ttaacagcat gttcgttgag tgattttagc aaatgccccc tcctctaatc    14940

tctttctctt ctcttcccca ggccactgtg aggtggtaac tcccactgcc atctgaacac    15000

tgttccccca ggtagttacc ccaaatctca aatggttgag cagctagagc tgtgggttgg    15060

aaaaatgggt accatttgca gggacccaga gagggtggct gttgctcaat atatctacag    15120

acttccaatt cagaaaataa tcttcccctt ttgacaagcc agagcttttt aaattccatt    15180

taggaaatgg ggaaaaggac agctacagtg aagcttttaa tttctgggtt atttggttcc    15240

atagctatga ggggtggtgg gtagtggact gttttcagct tggtttgtat gcagagaaaa    15300

gccagatatt ggagggggtg gggcacttct cgggcaggat gcaaggtctc catctgacct    15360

ctgcgcctta ccaggagctc acacactcac gcccatcacg tggctccaag ctgagtccag    15420

gcgggcctcg tccttgagct agcttgggca gggcaggact cccacccgtc taaggcctaa    15480

cagctcaggg agatgtctaa ttaagccatc ttctgggtga actctgaaga cagactcttt    15540

ccaaaagtca gagatcactt ggttgagtcc caggccagat tgatacggag agtttggcgg    15600

cacagcccaa ccgctcactg ccatggccag agggactttg cacaactaac actgaagagt    15660

gtgaaattaa ataagacttt aagactggta atcggtggca aataccagca caaaacacgg    15720

ctgaccccat gtcacacatt tccctcctct agggtctttc tttgaaagaa taagcaagaa    15780

accccaatcg agacaacccc tgatgtctcc cagactcaaa acctcacgcc ggcactgggc    15840

tttccttctt tgccccacgt gagccatgca gcacctctag tttccctacc aggatcccac    15900

caatgttctc cgtattggaa atttctgtgt tagaggctga actcatagta atttctaaaa    15960

ccaattaaga agaacttagc cagaggtcac agtaatgctg gaatcacaaa atgcataaga    16020

tttattttct tctggcccct ttctcatcca tgctgcctat gcctgtgcac ccacaagtct    16080

tatgtacatt aaatctccaa aatcaaccac caccatgcca cagagttttc actggacagt    16140

gtttcttagt tcccaccaca tacctccttt tccccatgca gacttatcat gttggtgtcc    16200

tgccacacag ggggcctgag aagaatgtca cccaatcgcc gctgctgtga gtgtgtaaag    16260

tgattaggag attaggagaa tgttgaaact cctgctggaa aaatgcaaag aaaatcctca    16320

ctttgagtca gttgtttaca gagccagtgt gtgtgtgcgt gtgtgtgtct gtaatataaa    16380

atggatgtga atatatatat acaaatagat atggttttgc ttttacttta atctgaatta    16440

tctagataat tgtctttatt caccacttga cttcaatggg tccacacaaa ttaggacacc    16500

ttatcttttt aggcatctag gctgctgctg atccccagtg cttccaacat ctcgcacacg    16560

ttggcactat gaggagcagt cacgtgccct tgggtttttc aaccactttg gaggctgatt    16620

gaggtccttc atacatgtat atttgtcgtg atgaaagttc catcggtaga gtggagccac    16680

cagagctttt atcaaaattc tgtgggttta tgagagatgg gtttagaaat ctatatggct    16740

ctgtggggct tctcggcttt ctaaaataag gcattaacac ccaagcttcc aaaaatattt    16800

gcagctctgg ggtttgaatc ttgaaaaaca aggagtgagg ggctgtgtat actaactaca    16860

gtggagattt ttttcattct ttaatgtgat ggagtccctt catgaaatga agctttaagg    16920

ggcatggtat tgtggggacc acagctattc tgaggtttaa aagaagaaac tggaatatga    16980

ttagtaaaca cattcagcag aaaagagctg gattcttatt gacttagtta taggtcatcg    17040

gctggcagtg caatgggagg aaatatttac tttacacata tactttatga tcttggggga    17100

attagaggaa attcaataag aaaacggcta gaaacattta aaacccttat ttaaaagact    17160

taagcaaatt agagtcttat cagattaaaa accactacaa atgtaagagc attgtcttca    17220

gtgaaacgct gtggggtctg agaaggagat tctccgccaa atctccggga taaaatgcgt    17280

catttaagca ccagataatg agcagaatgt aaattaattt aaccttcttt accaacaggc    17340

tgctagtgta atgtgtataa tttagtgata agattgcagg acctaatata gctggatgta    17400

tgagcctcag ctaatgcaga cctgtcacat gaggatgtgt tttactctga gcaggtgtct    17460

gtatgtgtgg aatggggtaa agtggaataa aaggttaaaa gcagaaatgc tgatttaaag    17520

cttactatga agaaattcct cccttgcagc taaattattc ttaaagtggg atgatactgg    17580

tgaagaaaga ctgaaaaaca attctcatgt gcgtctttgg actgcaagtt taaaatgggg    17640

aggagttgca gatagggttt gggggtggtc agggcaaagg agagacacat aagttgcaaa    17700

tatatttgta gtctgcttca tccactttgt tccacatcga ataagtttcc caatcttgtg    17760

aacaaggaca aggagggagt gttttaaaga tacttcatgc tggcattgca aatcattgac    17820

tgtaatgtca aacaaataca cattcagaga tgataacact aactccatag taaaacaatc    17880

gcccatgcag aaacccagag gagattagtt tgtcctctcc agctgaccta tgctggggga    17940

caaaaggact ttcaaaaatt attttgaata tgtttggatt tctttcttta atttctttgg    18000

aaattaaatt tgcttggaaa cagtgctata aagagttgat gtctccaaag gtgatttttt    18060

ttgttttata taaataaggt tttgcttttg ctagttgagc gcagttctag gcttttcgcc    18120

cttagctcac acacacccct tctgcctgct tggactttaa tggctcaaga cagccttgag    18180

ctcactggga aaagaaaatg actgttaaaa attatccttg aaattggtta tttggcaaca    18240

ttcttaattg tatggaaatt cattaaggca tatttcatat ataattagct caaggttgtt    18300

gattctacag gctttatgga tttaaatctg attgataata aagtaaacaa gagagtcgaa    18360

tttaaagcgt ggctctctcg ggttaggacg agcttaatac agtgtacaag gaatttgaaa    18420

gatctaggat atgtgtctta atcaacgtta agtagaatgg ataagctttc agcattttga    18480

aaacgctggg ttagggtttc tcttctattg tgtgttttct gtctggggac taataagcat    18540

cacagagaac gtgatctgag gcgacttttt attcttgtat aaatccagag tgaaccacca    18600

aacagttgtt cgtttaaagt caaggtaatt ttcttttgac gggtccattt gcttctcgat    18660

ttctaattta ttagcctgcc ttttcagggc tctgtcttct ttgcaattaa agcttcttca    18720

gattagcgca gcattcactt gacaggctgt ttggaaaatt taagatcgga gaggtgattt    18780

gttgctgttt ttcaaatttt ctagttttaa gtaacgtgtc tcctttttat atggggtggg    18840

ggattggaaa tggatgtagt gagacacaaa gagtgggtgt cttgttgatc cttgtacctt    18900

tctcttcttg accattccac tctcttctcc caagccttcg actcctagcc tcatctcttc    18960

acctttgggt tcgtactaaa agccggatcg ccttgggctg ggcaggagct gaattcccgg    19020

gagcttgcct gtgtagaccc agtgcgcacg gcgaggcagt agcccggccc cgcactgctg    19080

ataggtgcag gcaggacagt ccctccaccg cggctcgggg cgtcctgatt ggtgcggagc    19140

cacgtcagtc gcacccggag aagggtctgg gaggaggcgg aggcggagag ggctggggag    19200

ggccgcggcg gagtgacgtc tcggcaccag gaagcccgcc tctggtttta agatgttagg    19260

ccaacaggga agcgcggagc cgcagatctg gtccgtcgct cgcctgggtg cctggagctg    19320

agctgcggca aggcccggct cctgttcgac cgcccgaggg gtgtgcgtgt gcgcgttgcg    19380

gagggtgcgc tcagagggcc gcgtcgtggc tgcagcggct gctgccgccg caggggatct    19440

aatatcacct acctgtccct gtcactcttg acacttctct gtcagggctg ccgcgtgggg    19500

ggggggcggg cagagcgcgg tcggcgttag ctttccttat tggaggggtt cttgggggag    19560

ggagggagag aagaaggggg tctttgccca ctcttgtttc gctttggagc ttggaagcct    19620

gctccctaaa gacgctctga gtggtgccct tctgcccaca tcccatgtct tcgtttgccc    19680

gctgactttc cgtctccgga ctttttcgct tgagccttcc ggaggagacg ggggcagctt    19740

ggcttgagaa ctcggcgggg gttgcgtccc ctggctctcc ccgcagcggg gaaactccgc    19800

gcctagagcg cgacccggag cgggcagcgg cggctacggg ggctcggcgg ggcagtagcc    19860

aaggactagt agagcgtcgc gctccctcgt ccatgaactg catgaaaggc ccgcttcact    19920

tggagcaccg agcagcgggg accaagctgt cggccgtctc ctcatcttcc tgtcaccatc    19980

cccagccgtt agccatggct tcggttctgg ctcccggtca gccccggtcg ctggactcct    20040

ccaagcacag gctggaggtg cacaccatct ccgacacctc cagcccggag gccgcaggta    20100

aggcgccgcg ccgccctgca gacattcccg ctcagctgct ctgcgccacc cgctccctct    20160

cgccccaagg aagtcagccc ctccgggggg aggcgtggtg ggagtggtcg ttcgcctggc    20220

tccccgcaga acttccggga gccggaattt tgactacccc gcatcccttt agttctccct    20280

cgaccggccc ggctcctggg gcgctaaggg cgcgagcaat tctgccgccc tctctattcg    20340

taccctggcc tcccttctgt ttcctgggtc acaaaaatcc cagcatcttg attcgaggac    20400

cttcagaggc cgccgacctc tgtccctgtt ttcctctcgg ctttcagctc ccgaggagct    20460

ccactcgtta ggaaattgcc tgaaaccact cagaaatgcc cttcgcgaag aggcattttt    20520

tttttttttt tgggaaaggg ccggcgaact tcggtgccca accgaatccc cacatctttt    20580

cctagccttc ccaaaccgca tggaaatctg agctttctgc gagggggagg ggggtctgta    20640

aaccacgcgc gtgtgcgcgt cccaggagat ttggtgtgtc tgcgcagagg tgtataaata    20700

tacttgaaag cacaggctat aaaagtgaat gtgccgctgc agtgagataa acatgtaaat    20760

aaaacgtgcg gcgctggggg aggggaggaa atggggcgcg gacacccaca cttgcgcctg    20820

cacaccccac aggcgcagcg ctcctcgcgg cccggagccg ccgcgcgcac cctcctccgg    20880

cgccaggcag cccagctctt ccacggcttc tgccgccggt ccagttggcg tccgcgttgc    20940

aggtgggcat gctgacggga aagtgtgtgt gtttcgtttt cagagaaaga taaaagccag    21000

caggggaaga atgaggacgt gggcgccgag gacccgtcta agaagaagcg gcaaaggcgg    21060

cagcggactc actttaccag ccagcagctc caggagctgg aggccacttt ccagaggaac    21120

cgctacccgg acatgtccac acgcgaagaa atcgctgtgt ggaccaacct tacggaagcc    21180

cgagtccggg taggagccag cacggagtct gggagggatg gggggaggat gttgtggagg    21240

tacaggccaa gtagaccagg agagaatgtg gaaggcagcg ccgcctggga gggcgccggt    21300

ggggcgcagc tttgcaaagg cagaaggcct cgcggcggcc tggttgcgag attacagttc    21360

cctctccgag gccgacagga ctgccgccct ggctcaggct cccagagcgg caccggctca    21420

ctgccccgcc atcccgcgat ctcacgagct gggctgcatg ggcaatcccc tgcacaggac    21480

attgtgttcc tggcttgcag ttgccagagc agagctaata aaatccctac caggccaaga    21540

gccgcgaaca ggctccaacc tgtgagcctt taacaaggaa aacccgccag agacacggaa    21600

gagttggccc tccctgggaa acctttgtcc cggccctggc ccagcttttt ccctcctggg    21660

ctcgcgcttc ttacaccttc tttacggttg tttcggccat tcaggtctct cccacacacc    21720

ctatttccta gttttgtgat ctccgggagc aaagttttaa tacacaacta ctagtcctct    21780

tagaaggaga aagaaaaaaa gaagaaagac ttttctgctt ggtttattta tcttctctca    21840

ggagttgaac tctggaaatt gaaactcaca ccccctcttc taaattataa tcatagtttt    21900

gtaaaaaggg cttaccttaa ctttgtagca aatctgtact ttatggattg gcaaaaatga    21960

gctcaaataa ataacccaat agcaacgtcc tggtttatgc tggtcggtgg aagattccaa    22020

atttgttagg attctggaag cagaaaacag aatcaagcaa atcaagcggc atccagaggc    22080

tttgctgtta aaaaaaaaaa attaagtgct ctgggtagaa aaaataaagc ccccggttag    22140

agcagagcaa acaaaaagaa gaaaacaacg ataaaaagaa taaagaccaa aatgctctcc    22200

caaatcagag ggaatgaaga cactctctgg gtggcatttg tgcaaggcat gaggctatgc    22260

tggtggataa aaggccggga agaagttgaa aatggtttta gtttaactgt ccagagccag    22320

agctgggtcc tgggcggcgt ggttttgagc aaggtcagtc tttcattagc tctcttgcac    22380

atcaagggaa cgggcctctc acgtactctt ctcgcctgag caaagtttag atggcctagg    22440

gtagaaatgg caagtaatta aagacagagt ctatgggttt tctgggatcc ttcgaaaacg    22500

ccctcccacc ccgcccgcta ttccgcagct ccaccctagt gctttgtagc cgcggcgctg    22560

ggctctcctt gcagctgcct ctccttccag ggcggctgct tgtcgagcca agtgggagtg    22620

aggcgtgctt tttatagcag tcgggtgcaa agaggaaggg ggataaaaag gaaatcaaga    22680

atgaaaggaa aaagagaaaa agcggattac acggctgggc ccggcggaga tgtgtaatgt    22740

gaaacatcac tggtgtcagc tcggatatct caggccaggc ctctctccaa tacacaaaag    22800

ccgccgtctg gggcgacagg gaggcccgat gtggattggg atcggggttg cggctgggcc    22860

accggacacg ggtggaagcc ggccggcctg ggtggccgcc tgcaaagcca aacgacccgg    22920

ctgggcctgg cgcgcggaca ggcctgtggt gggcttaggg taaagaagag gcagagcgaa    22980

agaaggggga atctccaaaa ctaccctttc cgggttcccg gagtttaata tgccaagctc    23040

ctggagttaa cgagctgacg aagaggtggt cttttgctct ttatttggtt gttttgctag    23100

gcgagaaaga gtgttggcgg cctagtccct gttaagggag cacgtaccag ggggtggggg    23160

acgacagtgg aggtcaggga aggaagggag gaattgcgtg ggagaaagag cgatcctcta    23220

gtgcccttcc agccccttct cctcatccgt gggtctgtgg ctttggaatg gaagcaagtt    23280

tgcaaggtgc cccgggaagg gttggaaaag cctgctgccc cgcgtttgtt ttacattaag    23340

tgtttttgga cctggagaaa cgcctggctg agtgatcaaa ccgtccgcag gtctccatgc    23400

gttcggctga ggtttgtggc gtagctccga gtcccagctc gcaggccaga gcagaccagg    23460

tctcctgcgc ttggtggaga cccgggccag taactgaaag ctggccctgg tatcttggtg    23520

tgcagggcgg tgcagtgaag cgaggccagg gtgtgtgagt gcgctagcgt gtgtgtcggg    23580

ggaaggcggg ggttggcctc cgatggaagt tttagtaatc tgcactgtgg catctgtttg    23640

ctcccttgcc ccaaccgccc ccaggtttgg ttcaagaatc gtcgggccaa atggagaaag    23700

agggagcgca accagcaggc cgagctatgc aagaatggct tcgggccgca gttcaatggg    23760

ctcatgcagc cctacgacga catgtaccca ggctattcct acaacaactg ggccgccaag    23820

ggccttacat ccgcctccct atccaccaag agcttcccct tcttcaactc tatgaacgtc    23880

aaccccctgt catcacagag catgttttcc ccacccaact ctatctcgtc catgagcatg    23940

tcgtccagca tggtgccctc agcagtgaca ggcgtcccgg gctccagtct caacagcctg    24000

aataacttga acaacctgag tagcccgtcg ctgaattccg cggtgccgac gcctgcctgt    24060

ccttacgcgc cgccgactcc tccgtatgtt tatagggaca cgtgtaactc gagcctggcc    24120

agcctgagac tgaaagcaaa gcagcactcc agcttcggct acgccagcgt gcagaacccg    24180

gcctccaacc tgagtgcttg ccagtatgca gtggaccggc ccgtgtgagc cgcacccaca    24240

gcgccgggat cctaggacct tgccggatgg ggcaactccg cccttgaaag actgggaatt    24300

atgctagaag gtcgtgggca ctaaagaaag ggagagaaag agaagctata tagagaaaag    24360

gaaaccactg aatcaaagag agagctcctt tgatttcaaa gggatgtcct cagtgtctga    24420

catctttcac tacaagtatt tctaacagtt gcaaggacac atacacaaac aaatgtttga    24480

ctggatatga cattttaaca ttactataag cttgttattt tttaagttta gcattgttaa    24540

catttaaatg actgaaagga tgtatatata tcgaaatgtc aaattaattt tataaaagca    24600

gttgttagta atatcacaac agtgttttta aaggttaggc tttaaaataa agcatgttat    24660

acagaagcga ttaggatttt tcgcttgcga gcaagggagt gtatatacta aatgccacac    24720

tgtatgtttc taacatatta ttattattat aaaaaatgtg tgaatatcag ttttagaata    24780

gtttctctgg tggatgcaat gatgtttctg aaactgctat gtacaaccta ccctgtgtat    24840

aacatttcgt acaatattat tgttttactt ttcagcaaat atgaaacaaa tgtgttttat    24900

ttcatgggag taaaatatac tgcatacaaa ttggtctgga ttctttctcc cctcctctgt    24960

cactaacttg gccaggacat ctcagtcact gcttcctaaa caaaccagtt ccctctgcct    25020

gcctagttaa acatacaagg cagcagtcct tatttaaatt tggtagaaat aaatgatagc    25080

cattcatcag aaactaaaaa gaaaaaaaaa ggcattcccg ggggggaaaa gggctacaaa    25140

atctaatttt gtctctccaa tttttctttg gcttaaacct agaggattcc attatggcta    25200

gcaaataata tgaaaaagaa aaaagaagaa agaaatttag caagtccatc agcttaaaat    25260

gactctcaag tttactcctt tacggggaaa cctacacctc tagcaaattg ttctggagaa    25320

atatttgtgc atgtatacat gtatagttta tatgcatttc tctcaggagg aatacatcta    25380

taataaattt acagggaaac atctccagtt caaaatattt aggcttccac gtttatcttc    25440

aggcttaagt agagagatcc ttcatgttat attgcattac tatttccaaa tcctttggag    25500

acattaaaag aaacaaagat gatttctaat aactacagcc cttcagtttc tcaaagaact    25560

caggggttga gaggttagag tggagtttcc tgagtcttgt cgagcaatat gtagttgagg    25620

caaaggtcat gctcccggtg ttttgtttta aataatattg acccattaat tctaaacctg    25680

cttgttcctg aaattataca ggattatagt ttgcaaactg caggacaatg aagcaaatca    25740

agatgaatta cagccctggc cctccctgcc atcctctgac atctaaacag ggaatgagtt    25800

cggtgtgagt gtttaaatga actttaagca cccgatcctt ctttatccgc gattttcagc    25860

tttaaaaaaa tgtgaaattt gatttcataa caaatagaaa caaataccac ttagtcccag    25920

agaattcatc ctcatggcgc taggagggtc gttgtggagg tggggggagg gatgtgctga    25980

gatcttttgt tatgcttgtc aaccccccgc acaaccaaag tgggcgagaa caaacaccac    26040

gctggggaac ttagagcaaa aagtaaccgc cgattttctg gagccgacaa tatcattgtt    26100

ttttcgcctt agttgctttc atctgaatga aactttacct agaagctttt ggagctcgaa    26160

cactgagtct ttgttctgca agaaactgct gctgccactt aaagagatcg cagataatgt    26220

ccccgattta agatcagtgc tcaacgcaca ctttctttct ttttaaagct ctgcctccga    26280

cttgcggagg gatcacgcag cagtgggggg cagataaaag ccctttggac gagggtcacc    26340

tcccaccatg ttgttcactt gagagcagtg gagaggaaaa cggtccccac gggcggactt    26400

tggcttctgg agccgcaggg cccagcggtc ccggcctctc cgcctctcag cctggtaggg    26460

ggcggggagg gccaaagggc ggaggggaag gaaggagcta gaagagggga tttggggatg    26520

ggggctggaa gcgctaacga gacctgcccg gaggatttag gtctcctgca ggttggtgag    26580

tgatttggga gctctgggta aaagaggtgt acctcggcct agtttggttg ctgaactaga    26640

acaacgcgag gacatcaatc aatctgcagg aaacaaaaaa tggaagtcga ggtttaggaa    26700

gagttgtcac ttccccgact tgagtggtgc aggctggggg cggagacttg ggacctaaga    26760

gaggccattt ctctcacctc agctcccttc ccttggactt ccaaaaggaa taattttact    26820

ctctcctccg ttctccccac aactctcatc cccgctagcc cgcaggccgc ctgccccttt    26880

ccgcacctcc ttttcccatc cagcgagaga aacctagctc ccagagccgg               26930


<210>  2
<211>  22020
<212>  DNA
<213>  Homo sapiens

<400>  2
ctcccttccc tctccctgtg tctctccgcg gatctctgaa tctttctgtc tttggttttc       60

tcattctctt ccaacttttc catgagattg cctatcctcg ccaccagctg aaggcaaggc      120

cgttctgcta cgagcgcctc ttaatctcta caaaatgaaa agaaaaaaag ggaggattat      180

tagcccatta ctcagaggaa tggggaggct gcaaaaatcg tcgatgggca gaggtgaaga      240

tgtctttctc ggactgcact ttccggtgtc ctgtaactag agttcagttg tgggacttgt      300

tgaagaaatt tgattttctt gcctcggcga gatttcaaaa accagaaata gaaattctca      360

gagtcagaga ggaaatacaa ttaaacagca cgtgggcatt ttccccctca tttctctccc      420

cttaaataac actgctttga gtttccactg ggtaaagaga gaaagtttga gttttcacgg      480

atgttacgtg gaggttagaa atggcttaaa atgtagatct ctaatcagtt ttcttcgtgg      540

ctgaagaggc taaccctttc cataaaatga gtccatctgt cgactgttag ctatttcaaa      600

gtgaagggat ttagcactca aaacaaattg agcaagtttg tttgcctgtt tttactgcta      660

actcaaatga attcaaaaca cggagtaatt caagaaaaca cataacatgt tccagacagc      720

ccccaaaagt agggaaagcc cagcacctat atagtgacta gggttagttt taagcgccaa      780

gcttttttaa acgtatctat tttatgcaca ttctcccgag tcactatata tttctaaaat      840

tgcgagtatt ggtatattga tttaggaaga gcaatacaac ttttagaggg aactttattc      900

tcaattaggg accaaagaga tgtcttttta atagcgggcc tgagttttgc tctcaagcag      960

gaattaatat tggtgggaaa atccgaatcc aggagcaatg gctgtgttcc ggcactttcc     1020

aaaaacatac attaacagga tgcccttgag attgaaaaaa cattgtccca tatgcctggc     1080

agaagccttc acacctggtc ctccaggcga attatattta tagtccttcc actcagaggc     1140

aggacagagc caaaatattc tgctcactac caaaatacac atttttgctc aagtcaagaa     1200

atcagaaaat cagggttcag aagtaaggca cacttttcga gtgagaatat gcccctgtaa     1260

tttcacatac tctttgcttt gcaggagcaa atgtggactt gagggaaact ctctccccca     1320

cccccacttc tatcccgtgc aatgtaatac catcctcgtc aggaacctga acctcgtcat     1380

tttaagaaat gagatatccg tgactcaggg tgaacttgtt gaatgtaggt acagcagagg     1440

aaattctaga ctctatgagt gtttgagcct tgtccagtgc aaacctttcg tgaacactgg     1500

gtcagtgcgt ggccgtgccc acctgtgcgc agacactctc agcatgcctg gtccacccgc     1560

cttgacatcg ggcgcggtgt cccagctaag ctgggcccag cgtcccggcc ttccccagct     1620

gacaagcgta ggtcgttcgc tcccggcttg tggccctccc accctctccc actagctcac     1680

tccattgttg tagattctct ctctcactca tcctctccca tccccaccgc gcccacctcc     1740

actcccgccc tctaccggtc tctcactttc ctccctccgc agtccctctt tgctgtgacc     1800

tctttcctca actctgcagg cctgaaagaa ggtcacacac gcacgctcac acccacactc     1860

cacacgcctc gtcccaaaca accccatgaa cattgtcctt tgttccgtct cttgggccac     1920

tttccctgtc gttcctccca gcccgtcctg atttgctccc caaaagtacg tttctgtctc     1980

cccgctgccc tggcgctccc cctttgattt attagggctg ccgggttggc gcagattgct     2040

ttttcttctc ttccatccca tcctcccttc tggtcctcct ttccacagtg ggagtccgtg     2100

ctcctgctcc tcggttggct cctaagtgcc ccgccaggtc ccctctcctt tcgctctccc     2160

ggctccggct cccgactctt cggcccgctg gcatctgctt ccctcccctg cctcgtttct     2220

cgtcgcccct gctcgctccc cccggcgctc gcccgggcgc tgtgctcgct cctggatcgc     2280

cagccgcgca gccgggctcg gccggccgcc cgcgcgccac tgtgcagtgg agtttggtgg     2340

aatctctgct gacgtcacgt cactccccac acggagtagg agcagaggga agagagaggg     2400

atgagaggga gggagaggag agagagtgcg agaccgagcg agaaagctgg agaggagcag     2460

aaagaaactg ccagtggcgg ctagatttcg gaggccccag tgcacccgtg gactccttcg     2520

gaacttggca ccctcaggag ccctgcagtc ctctcaggcc cggctttcgg gcgcttgccg     2580

tgcagccgga ggctcggctc gctggaaatc gccccgggaa gcagtgggac gcggagacag     2640

cagctctctc ccggtagccg gtaagtggag gccatctatc ccgcagggat gtgagataat     2700

gcgagtctgg aaatttgttc cacttcggag aatcttcacc gtaggtgatt tgtggctttt     2760

ggggctaagt ttcgcccaag gtaacgcagt cggcaaacag accttgcaaa gccctgttcc     2820

tttcgtcccc cgccacagac actaacaatc tacagggtgc tgaagtcgag agggaagcca     2880

gaccgtggct ggcatttaaa acgaggtatc ttcccttaaa tctcggtgcc aacactgcag     2940

gaacaaatcc tcgggccaag gattagcatt ctcaagataa agggctgggt acaaagtttc     3000

agctactgga agattagccc ccttcccatt gttatccatt gggaaaaaaa agaaaagaaa     3060

aagattccat cttaactggc agttagtgac ctctcaggcc caagcgaatt acctgggagc     3120

caggcctgga tgccaagctc tcaccatttc tttggattgt aactccttta aattgatcac     3180

cagtcaactc caatctggca cttcaggaga tacactttaa atggatgcag agaattattt     3240

tccagctgga gattaagaaa aaaattttcg attctaaacc tccgaaatat gttcctcttt     3300

tccagtttaa ccactttact ttcttaagca atttagtaat caaactatca taaggtggtg     3360

tgattttttt ttactctttt gtgtgagtat tgtcttacta aactaaacgg aaaaaacttt     3420

taccattata aatgtaaata tcagaattca tacattctaa aatattttta tgaaaaatta     3480

atctgattta aagaaatttc cttgcatttg ttttagtcta tcaatcaaaa ctaaagatgc     3540

ttttatcaca caaaatatca ttttggcaga aatccatcta aaattcaaat accaataata     3600

tcaagaaaac aaagcacata agcaaaataa attgaagatt tttgttgatg taacatgagc     3660

atacaacatt tcaataacca aactttccct aaaaaattaa atagccactt catttgtgga     3720

atgttttact ttaactcagc aaaattacac ttaaattatt taggtgcttt gttcccttaa     3780

gttaagcgtg tttgtcttca aatgttccct aaagcactta tattaattgg ttgtaaagaa     3840

cgcatacaca tggtaaaata cagaactgaa ctgagcagta ttttaatttc ccttaaataa     3900

ttacttacta caaattaatt tactggctaa tttcacaatt tagttcattt aaaacacatg     3960

ttcctgtgct gtttattttt aaactttcca ttaaagattt tgttatgggg taacaaagtg     4020

tatgaaaagg ggggaaatgt gaaaggatct gggattattc gaactgtatt tttcctgcac     4080

tttcagtctt gcggtagtca tcagaaatta ttttttagca aattgtttta tttcttaggg     4140

cttgcctgcc tgctttgcca tggttcctca tcctccatta gccgtgtagt gctttttgtg     4200

tgctcacaat ataaaaccca agttggccaa aacaagagtc ccttggcata tacattccaa     4260

ctagaacatg aactttgggg gtgagaacta cctcccatca ggaaaagtct cccatctcaa     4320

tttgtgagat tagccattga agccagttcc gaagtctggc agccaaattt ctcacagaag     4380

acttgtcttg atagggcaag tttaaggatc agcaggcggg aattggaggt ctctttttaa     4440

aaaattatct tccccagtta tttagactca gttcttctag taggcctggt cattaaatga     4500

agcataaaaa tgcaagtctc aaggctcatt ttgactgcaa aataaatctc caagtcacaa     4560

ggacatgtag gagtgagcta aggaacacgc cttgaccttc ttttcagtcc ttagagtgga     4620

gctctatgag ttcttgaaga tttgttttgt attgctttgt ttggtcttca gcactgaagc     4680

acggggaagt ggggggaagc atgtgtaata attgactgac tttacaccaa gcaacgcaat     4740

ctttttcttc tgtatatttc attctttaaa aaaaataaat aaataaaaac tatttgcagt     4800

taccatctgc agtgctccgg ctaccagcta ataatgcagc cagttcagac atataaaaaa     4860

aaaagattat cgaaatgatg atgacatgca aatttcctcc gaaattatca taagtaaaca     4920

tttgaagtct ggactaataa aatcccatct gtgttacttc atatcgagtt agtagaaagc     4980

tgtgataatg aattttgtaa tatctcacga acagacatct caatcaggga ctaatcctgt     5040

gattttactg cagaatcact aaatctggag ccgccaaact gctacttctg ggcccacggg     5100

cccacaagga tcgaatcggc agagtccccg cccgcgttct cgctagcggg tgggggaacc     5160

gcctggccgt ccccaccctg gatccccacg ccacagcgcc gggcagcccc tcctgtaggc     5220

agcgaccttg gccagaggct ccccagggcc cagctccctt caggagaggc cgagacgcag     5280

ggaaacggta ctcaggccag aggcaggccc gcagctccct gccccgcctc tgtgcctccg     5340

ccaacccgac aacgcttgct cccaccccga tccccgcacc cgcgcgaagt gggccctccg     5400

gtcgtcggcg taccctggtt agcgtggaga gaggcaggcg ctgagatcga aggggcctag     5460

ggagccctgg accttctttt cttgtcttta aagcaaccgc ggctcttcta cccacccggt     5520

ggagcccctc gagacccacc tctcccggct tgcctgtggc agagaagggg gagcgcgtta     5580

aatgcttggc tcgctgcgtt gtggttgaaa acgtgaaaaa gatttggctc gcccgggaga     5640

gaaaggggga gaactgggta gcagttatac cagagctatt tctccgtcct tggcgggcag     5700

taaaccctcc aagaacgttt gccctgctct cctcagtctc gctcagtcca cccagtgtct     5760

ctcctctgcg atcttaaatc atactttagg gtaattattt gtagtaagta aataaatggc     5820

cgggttagta tctctaggag aaagtgtggc taaatatgga aaagtggctc ctgatggatg     5880

agaggcccga actcagctcg ctcctgaaac accctaggcc aagagcccgt tcgtttcaga     5940

attacagaaa accgagggaa actgctgtct aggacagggg cacgttggcg ctgatgttct     6000

acaaatgttt accgagctcc aactaatgga caagcactga agggtggtct ttgcatacag     6060

cttcccaaag agaaaagtcc tctccaccca cccactcccg ccgccattgc gttcagatga     6120

gttcttaacc ccggcaccga gattcttgaa agtaggtcca cagcctcccc agcacactgt     6180

ggctttatag tcctctaacc tctgggcact tttgcggcaa ctctggaggg agatcccctc     6240

ttgataaata aatgtcctgg gcccgaggct aggctggaga tgctgctgca cagccagagg     6300

ctgtcaggtc ggaaaaacac gcctgaagcc tagcacacag taggcgccta acagctagtg     6360

taacgtagtc tcatctgagc cctgctcact cgacggccgc cgcttcttac agccttcctt     6420

ctcttctgtt ttgcagataa cggggaaatg gagaccaact gccgcaaact ggtgtcggcg     6480

tgtctgcaat taggtaagaa cccccttctc ctgcccgggt catcggacgg gaggccgcgc     6540

cacgtgaggg cggcaagagg gcactggccc tgcggcgagg ccccagcgag gggcgcttcc     6600

ccgaggggcc agcctgggca ggaaggaaat cagaaccaaa tcgccagtgg cctctccctg     6660

tggcggggcg gtggactagg aagcagcggc gcgctgtgta ccgaagcccc cagcctactc     6720

ctcccggctg gaaccgccgg caaccgggga ggcgcagaaa gagtacgcca tcctgccccg     6780

ggttgccaga gggtccgggg gacggggatg ccgtcagctc tttcctctaa ctgggtcttt     6840

gctctttgtc cctctttctc ctccggcctg cctcgcccct ccccctcctc ccgtccccgg     6900

ctcctttcgg ccgcggtccg ggacgcctct ctccgcacgt ggggcgggcg cgcgcgtggc     6960

ccaggcgtgc agccggcggc cgttgaatgt ctcttctcca aagactccga aatcaaaaag     7020

gtcgagttca cggactctcc tgagagccga aaagagcagc cagcagcaag ttcttcccgc     7080

ggcagcatcc tggcgccaat ggtaaggccg ggagggaagc gcaggccgcg cgctgggcac     7140

ccgcctccgg gactctgggc ctcgggcgaa agcgcaagaa ggcgaggccg ccagacctga     7200

cgcgcctgct gcttgaactt agacactccg cctctgggtg ggacgggaag cagccgtccc     7260

agggacgtta attcctttcc ccaaattata ctgcactcct gagacccaac acctctctct     7320

ccctctcgct cgctccctgt ggtctgatcc cctgcgcacg ctccagcaaa cctcggcgtc     7380

taggctggcg tggaaaagtg gtccaacagc gacctctgtc gctcgttata tcccgctgcg     7440

cgcagcacca ccagggccca ctcagtcact caggctctca gccacgcccc acccagactt     7500

gtgggtgcgc ggttcatcgc gggaggcaag caagggaaac ttgagttggc gaaggtttgc     7560

tttggctggt tgggggaggg gcggggggcc gacaacatcc ctgaagagct ggagggcagc     7620

cactgtgctt agcagcccag ggtagaatgg aggtttgccc ctgtcgacgc gaacctgcct     7680

gaagtactgg ttgccaggcc ttgggttttg gcgatgtcct tgcttgattg gctggtttca     7740

ctctggagga atcgagggac attgccagag gaggtctaca ggcttatgta aaaagttaaa     7800

aagtctccaa cctacgccac aggcctttcc tgaattgaaa cttgttctat ggggcggagg     7860

ggggggtgta agggatgaga gagggaaaat gcctttcttt tcaaatacat ggaaaaaaac     7920

ccctcaaatt tactgttcct ctattttcct ggctccgtag taaataagtg cctagcctta     7980

ggaggctatt gacctttgat aatgtgagca gataaagccc cccccccccc cccacagccc     8040

tcggccccta accccctctt tccggattaa agtgtaagaa tacaaatgta atatgggatg     8100

gaggggggcg atttgggacc ccggtcaaaa aaacaaaccg tattactaag aagaaaacaa     8160

aggtcttgca ttggagtttc cccgtgaatc tgagagaaaa tgatcatttg ttgaaatgaa     8220

gcgtctaaag cgatcctgtg cttcacgccc ggacactgca ctacaccgcc agtcgccctg     8280

ctgggccagt taaacgctca cttgtccggg attaacccca tggggttaaa tgggggcaat     8340

gcagagataa cgtcgcgtga tttctgtcat ttagattgtg ttaaattctt cttctgtttg     8400

ataatcggta gtaaaaataa attattagac cgtagtatgt ttgggatatg gttaaaaatc     8460

aagagcagcg atgacttctg gggagaatgc tttgcgcggg ctcagccctg gttccggcca     8520

gagtagagga gctccccaat ctcgcttcgc gcggggcggg ctcgcagtcg ccaagccgag     8580

gctgacattt cttattgtgc tgggagccag agagacgcaa aatgtctcct tcccccagtc     8640

cctaccccag gtttcctaga catggggaat gcattctgag gacaggtgga gaagcctacg     8700

gtaggatggg gtcctcgtag gtgagcagga aacggctaag agcagaggag ttctgcttgc     8760

gccagtcaca agccgcgcag gcgcccctgg tcgttcgctt ttgataacta gcacataaag     8820

aactagaaat aatgaatgat tgctttctta accattactt tcaggcccgc attgttttag     8880

tgcacgtgaa aggctcttcc cctacactca atatgtcttt ttctactttt tgaccgaaaa     8940

gaaaaattgc tgcctaaaca cgtttaatgc cattaattaa gaaaaggcat gtaatgggaa     9000

gaaatgctga aaatcttgat ttaattggct tttaaggaac tagtagacga caaaaaaaaa     9060

tcacacgagt gggcaaagct atagcactgc tgaaggatag agcacctatc cttccctgat     9120

tttaagttaa cttatggaat atccaaagtc ctggccacat cctgcttgta aaacaaaagg     9180

atttatttct tgtgtttttt taaagttttt ctttgctttt aaagagaaaa aaagttcaca     9240

atgacatatg acttcttcaa aaggccgtga tagtctatta cgctaccctc tccgcctctg     9300

cccccaacgc cgcccaaaaa taccatgtcc tcgttaaaga ctaaacgttc tgtataggca     9360

gagtccacct ctaagcagtc caggctctgc cttccttccc tagtgagtcc cattctcctt     9420

ggtatccatt gggcggatgc ccagcctgga tagaaccccg aaacgggggt agcacgagag     9480

cgactggaga cccctaaaag ccagaggttt gagagagggt ggacgcagct agcagaagat     9540

ggtgtagaag ccagctgaga acgaccccct agagcaaaga gacctttctt tggcttttct     9600

tgctttgggg gtcctgaaag gaactcataa aatggtcttc accctcagga ggaggacgga     9660

ctgaccctcc tctgtcactg gcttaaaaag tttcagggcg gcggctctgg gttccgtgct     9720

gaaatcggac tgcactgcag cccctttgga cctgacgcct ggctttgcgt cccgacaagg     9780

ggcgggtact tcccccggcc tcccccagga acgcattaat tgttaaatag ctttggccca     9840

gtggatgggc tgaaagtgtt cgacccaagt cgctggtgtg cacagacttc ctccctctgg     9900

gaggtgggct ccatggcccg ttgtggcacc cccagccgcg acacacacct tcacacgcgg     9960

cagcagctcg gtcccaacct tcttcgaagg acctgggtta accctggcgg ccttggcggc    10020

cgcagacccc tctccgccgc cccgcccccg cgcctctcat tcaatcagcg aatgtttgcg    10080

gagcatatgc tacgtggact cctaatgtac cccctgaaag caaataatac agttttcctc    10140

gccgtcatga agggatttta atcctaacat ggacaccagc gagatcagcc cagaccgtct    10200

ctagcaaaac gcaaaatggt ggtgcgtggg gtggtgacca aggtcctgag ccttgtcaga    10260

aagaagggga tgtgtagaga aaggtggaga actctagctg tggctagcgc ggaagggaca    10320

ggtgcttgcc gaagggggca tgaggcttga ggaaaaagca acgaaatagg ggtaaggaga    10380

gttttccatt ttctttcctc cgcccgacct ccgccatccc attctcccct cccctcaccc    10440

accccccgcg ccaatcaaat ctgcagctca cttgaaaggt gccccgccgc gttgtggttt    10500

ttcaccccca ggggaaattg taccagttgt ccgaaagtag tcagtccctg cggatccctg    10560

cccgcaaaag tggtcttcac aggtcgcgtt cctcgctgct gactcggtac acaaagtttc    10620

ttaaggctgg ttcggctgtt attcctcacc gcccgctgct aatatatgca gcagttgtta    10680

gagcggctcg ggggaaaagg aaatgtataa cgaaagctta ttcgtgagca ggaatatact    10740

aatggaacaa tctgatgtct tcttaatcct atgtaaaaag ctttgtcgtc ttcctaatat    10800

tgactgaatg ggtaattaat ggctcttcat ctacgcgaat accctgtaat ccaagatagg    10860

caaaagacta caagcccaag gtaagaagac aaaaggccca actgcagcgg cgtttgcccg    10920

cctcctaacc cccagggtct ctgactatga gagtcttctc tcatacgaga aaaagcagga    10980

gtgggagaat atatacctat catttcgggg ctagacttca ccgcagcacc tgaccaccca    11040

gctcagtctt ctgttactct gtctttccac ctccagtccg tctccctgca ttttttttct    11100

tcttaactcc tctaggatga cctcctacca ccaccgccat tatggtccta ataacctttc    11160

cccctaaacc ccacatcttt cacttcagca accaatgagg ctgttttctg atccaggagg    11220

agattctttt cttttagaac cccatgcgta cagtctttga gaactaaagt agttggtagg    11280

ggaggaagaa attaatagaa agggagagag catacagaat tgtgtgtgta tgttaaagag    11340

cgaccaggaa tgacagagtc cacttctttg tgaggatctg acgggaagag tgtccaacac    11400

tctacagcat gtttttaaca ggctgacatt ttaatttaaa cctttagaag taatatatta    11460

cttgggttac tacaatgagg tgggttcctt tttttttgtc agctgacagc ttttaaaata    11520

ttatttcgct agggaaataa aagcttcatc tcagaattat aggtgggtat ttttggattt    11580

aggtgattta tggtcaccat gacaactaat gctgaatgtt agctaccaac atgtctggga    11640

gagagaaaac agaaagaagg gagagcaaaa gaaatagaaa agggagatgg acataacctg    11700

gagagggaag aaaagagaaa aagaggagga cagatgagtg tttaatccaa ctgtggttta    11760

aaaaagtggc gggggggtgg gatttcattt accccctagc aatttctttc tttcaggacg    11820

tggatatata tgttaaattt aatattcaac ctttccttcc ctttctccca aacacatgtg    11880

ctataccatt cttccttatt taacttagtt cggcaagtag ttgctttctg gagactcagt    11940

gacacctagg aaaactgtgg cagtaacatg caaatgtgag gaagcattaa cagcatgttc    12000

gttgagtgat tttagcaaat gccccctcct ctaatctctt tctcttctct tccccaggcc    12060

actgtgaggt ggtaactccc actgccatct gaacactgtt cccccaggta gttaccccaa    12120

atctcaaatg gttgagcagc tagagctgtg ggttggaaaa atgggtacca tttgcaggga    12180

cccagagagg gtggctgttg ctcaatatat ctacagattc caattcagaa aataatcttc    12240

cccttttgac aagccagagc tttttaaatt ccatttagga aatggggaaa aggacagcta    12300

cagtgaagct tttaatttct gggttatttg gttccatagc tatgaggggt ggtgggtagt    12360

ggactgtttt cagcttggtt tgtatgcaga gaaaagccag atattggagg gggtggggca    12420

cttctcgggc aggatgcaag gtctccatct gacctctgcg ccttaccagg agctcacaca    12480

ctcacgccca tcacgtggct ccaagctgag tccaggcggg cctcgtcctt gagctagctt    12540

gggcagggca ggactcccac ccgtctaagg cctaacagct cagggagatg tctaattaag    12600

ccatcttctg ggtgaactct gaagacagac tctttccaaa agtcagagat cacttggttg    12660

agtcccaggc cagattgata cggagagttt ggcggcacag cccaaccgct cactgccatg    12720

gccagaggga ctttgcacaa ctaacactga agagtgtgaa attaaataag actttaagac    12780

tggtaatcgg tggcaaatac cagcacaaaa cacggctgac cccatgtcac acatttccct    12840

cctctagggt ctttctttga aagaataagc aagaaacccc aatcgagaca acccctgatg    12900

tctcccagac tcaaaacctc acgccggcac tgggctttcc ttctttgccc cacgtgagcc    12960

atgcagcacc tctagtttcc ctaccaggat cccaccaatg ttctccgtat tggaaatttc    13020

tgtgttagag gctgaactca tagtaatttc taaaaccaat taagaagaac ttagccagag    13080

gtcacagtaa tgctggaatc acaaaatgca taagatttat tttcttctgg cccctttctc    13140

atccatgctg cctatgcctg tgcacccaca agtcttatgt acattaaatc tccaaaatca    13200

accaccacca tgccacagag ttttcactgg acagtgtttc ttagttccca ccacatacct    13260

ccttttcccc atgcagactt atcatgttgg tgtcctgcca cacagggggc ctgagaagaa    13320

tgtcacccaa tcgccgctgc tgtgagtgtg taaagtgatt aggagattag gagaatgttg    13380

aaactcctgc tggaaaaatg caaagaaaat cctcactttg agtcagttgt ttacagagcc    13440

agtgtgtgtg cgtgtgtgtg tctgtaatat aaaatggatg tgaatatata tatacaaata    13500

gatatggttt tgcttttact ttaatctgaa ttatctagat aattgtcttt attcaccact    13560

tgattcaatg gtccacacaa attaggacac cttatctttt taggcatcta ggctgctgct    13620

gatccccagt gcttccaaca tctcgcacac gttggcacta tgaggagcag tcacgtgccc    13680

ttgggttttt caaccacttt ggaggctgat tgaggtcctt catacatgta tatttgtcgt    13740

gatgaaagtt ccatcggtag agtggagcca ccagagcttt tatcaaaatt ctgtgggttt    13800

atgagagatg ggtttagaaa tctatatggc tctgtggggc ttctcggctt tctaaaataa    13860

ggcattaaca cccaagcttc caaaaatatt tgcagctctg gggtttgaat cttgaaaaac    13920

aaggagtgag gggctgtgta tactaactac agtggagatt tttttcattc tttaatgtga    13980

tggagtccct tcatgaaatg aagctttaag gggcatggta ttgtggggac cacagctatt    14040

ctgaggttta aaagaagaaa ctggaatatg attagtaaac acattcagca gaaaagagct    14100

ggattcttat tgacttagtt ataggtcatc ggctggcagt gcaatgggag gaaatattta    14160

ctttacacat atactttatg atcttggggg aattagagga aattcaataa gaaaacggct    14220

agaaacattt aaaaccctta tttaaaagac ttaagcaaat tagagtctta tcagattaaa    14280

aaccactaca aatgtaagag cattgtcttc agtgaaacgc tgtggggtct gagaaggaga    14340

ttctccgcca aatctccggg ataaaatgcg tcatttaagc accagataat gagcagaatg    14400

taaattaatt taaccttctt taccaacagg ctgctagtgt aatgtgtata atttagtgat    14460

aagattgcag gacctaatat agctggatgt atgagcctca gctaatgcag acctgtcaca    14520

tgaggatgtg ttttactctg agcaggtgtc tgtatgtgtg gaatggggta aagtggaata    14580

aaaggttaaa agcagaaatg ctgatttaaa gcttactatg aagaaattcc tcccttgcag    14640

ctaaattatt cttaaagtgg gatgatactg gtgaagaaag actgaaaaac aattctcatg    14700

tgcgtctttg gactgcaagt ttaaaatggg gaggagttgc agatagggtt tgggggtggt    14760

cagggcaaag gagagacaca taagttgcaa atatatttgt agtctgcttc atccactttg    14820

ttccacatcg aataagtttc ccaatcttgt gaacaaggac aaggagggag tgttttaaag    14880

atacttcatg ctggcattgc aaatcattga ctgtaatgtc aaacaaatac acattcagag    14940

atgataacac taactccata gtaaaacaat cgcccatgca gaaacccaga ggagattagt    15000

ttgtcctctc cagctgacct atgctggggg acaaaaggac tttcaaaaat tattttgaat    15060

atgtttggat ttctttcttt aatttctttg gaaattaaat ttgcttggaa acagtgctat    15120

aaagagttga tgtctccaaa ggtgattttt tttgttttat ataaataagg ttttgctttt    15180

gctagttgag cgcagttcta ggcttttcgc ccttagctca cacacacccc ttctgcctgc    15240

ttggacttta atggctcaag acagccttga gctcactggg aaaagaaaat gactgttaaa    15300

aattatcctt gaaattggtt atttggcaac attcttaatt gtatggaaat tcattaaggc    15360

atatttcata tataattagc tcaaggttgt tgattctaca ggctttatgg atttaaatct    15420

gattgataat aaagtaaaca agagagtcga atttaaagcg tggctctctc gggttaggac    15480

gagcttaata cagtgtacaa ggaatttgaa agatctagga tatgtgtctt aatcaacgtt    15540

aagtagaatg gataagcttt cagcattttg aaaacgctgg gttagggttt ctcttctatt    15600

gtgtgttttc tgtctgggga ctaataagca tcacagagaa cgtgatctga ggcgactttt    15660

tattcttgta taaatccaga gtgaaccacc aaacagttgt tcgtttaaag tcaaggtaat    15720

tttcttttga cgggtccatt tgcttctcga tttctaattt attagcctgc cttttcaggg    15780

ctctgtcttc tttgcaatta aagcttcttc agattagcgc agcattcact tgacaggctg    15840

tttggaaaat ttaagatcgg agaggtgatt tgttgctgtt tttcaaattt tctagtttta    15900

agtaacgtgt ctccttttta tatggggtgg gggattggaa atggatgtag tgagacacaa    15960

agagtgggtg tcttgttgat ccttgtacct ttctcttctt gaccattcca ctctcttctc    16020

ccaagccttc gactcctagc ctcatctctt cacctttggg ttcgtactaa aagccggatc    16080

gccttgggct gggcaggagc tgaattcccg ggagcttgcc tgtgtagacc cagtgcgcac    16140

ggcgaggcag tagcccggcc ccgcactgct gataggtgca ggcaggacag tccctccacc    16200

gcggctcggg gcgtcctgat tggtgcggag ccacgtcagt cgcacccgga gaagggtctg    16260

ggaggaggcg gaggcggaga gggctgggga gggccgcggc ggagtgacgt ctcggcacca    16320

ggaagcccgc ctctggtttt aagatgttag gccaacaggg aagcgcggag ccgcagatct    16380

ggtccgtcgc tcgcctgggt gcctggagct gagctgcggc aaggcccggc tcctgttcga    16440

ccgcccgagg ggtgtgcgtg tgcgcgttgc ggagggtgcg ctcagagggc cgcgtcgtgg    16500

ctgcagcggc tgctgccgcc gcaggggatc taatatcacc tacctgtccc tgtcactctt    16560

gacacttctc tgtcagggct gccgcgtggg ggggggcggg cagagcgcgg tcggcgttag    16620

ctttccttat tggaggggtt cttgggggag ggagggagag aagaaggggg tctttgccca    16680

ctcttgtttc gctttggagc ttggaagcct gctccctaaa gacgctctga gtggtgccct    16740

tctgcccaca tcccatgtct tcgtttgccc gctgactttc cgtctccgga ctttttcgct    16800

tgagccttcc ggaggagacg ggggcagctt ggcttgagaa ctcggcgggg gttgcgtccc    16860

ctggctctcc ccgcagcggg gaaactccgc gcctagagcg cgacccggag cgggcagcgg    16920

cggctacggg ggctcggcgg ggcagtagcc aaggactagt agagcgtcgc gctccctcgt    16980

ccatgaactg catgaaaggc ccgcttcact tggagcaccg agcagcgggg accaagctgt    17040

cggccgtctc ctcatcttcc tgtcaccatc cccagccgtt agccatggct tcggttctgg    17100

ctccggtcag ccccggtcgc tggactcctc caagcacagg ctggaggtgc acaccatctc    17160

cgacacctcc agcccggagg ccgcaggtaa ggcgccgcgc cgccctgcag acattcccgc    17220

ttagctgctc tgcgccaccc gctccctctc gccccaagga agtcagcccc tccgcgggga    17280

ggcgtggtgg gagtggtcgt tcgcctggct ccccgcagaa cttccgggag ccggaatttt    17340

gactaccccg catcccttta gttctccctc gaccggcccg gctcctgggg cgctaagggc    17400

gcgagcaatt ctgccgccct ctctattcgt accctggcct cccttctgtt tcctgggtca    17460

caaaaatccc agcatcttga ttcgaggacc ttcagaggcc gccgacctct gtccctgttt    17520

tcctctcggc tttcagctcc cgaggagctc cactcgttag gaaattgcct gaaaccactc    17580

agaaatgccc ttcgcgaaga ggcatttttt tttttttttg ggaaagggcc ggcgaacttc    17640

ggtgcccaac cgaatcccca catcttttcc tagccttccc aaaccgcatg gaaatctgag    17700

ctttctgcga gggggagggg ggtctgtaaa ccacgcgcgt gtgcgcgtcc caggagattt    17760

ggtgtgtctg cgcagaggtg tataaatata cttgaaagca caggctataa aagtgaatgt    17820

gccgctgcag tgagataaac atgtaaataa aacgtgcggc gctgggggag gggaggaaat    17880

ggggcgcgga cacccacact tgcgacctgc acaccccaca ggcgcagcgc tcctcgcggc    17940

ccggagccgc cgcgcgcacc ctcctccggc gccaggcagc ccagctcttc cacggcttct    18000

gccgccggtc cagttggcgt ccgcgttgca ggtgggcatg ctgacgggaa agtgtgtgtg    18060

tttcgttttc agagaaagat aaaagccagc aggggaagaa tgaggacgtg ggcgccgagg    18120

acccgtctaa gaagaagcgg caaaggcggc agcggactca ctttaccagc cagcagctcc    18180

aggagctgga ggccactttc cagaggaacc gctacccgga catgtccaca cgcgaagaaa    18240

tcgctgtgtg gaccaacctt acggaagccc gagtccgggt aggagccagc acggagtctg    18300

ggagggatgg ggggaggatg ttgtggaggt acaggccaag tagaccagga gagaatgtgg    18360

aaggcagcgc cgcctgggag ggcgccggtg gggcgcagct ttgcaaaggc agaaggcctc    18420

gcggcggcct ggttgcgaga ttacagttcc ctctccgagg ccgacaggac tgccgccctg    18480

gctcaggctc ccagagcggc accggctcac tgccccgcca tcccgcgatc tcacgagctg    18540

ggctgcatgg gcaatcccct gcacaggaca ttgtgttcct ggcttgcagt tgccagagca    18600

gagctaataa aatccctacc aggccaagag ccgcgaacag gctccaacct gtgagccttt    18660

aacaaggaaa acccgccaga gacacggaag agttggccct ccctgggaaa cctttgtccc    18720

ggccctggcc cagctttttc cctcctgggc tcgcgcttct tacaccttct ttacggttgt    18780

ttcggccatt caggtctctc ccacacaccc tatttcctag ttttgtgatc tccgggagca    18840

aagttttaat acacaactac tagtcctctt agaaggagaa agaaaaaaag aagaaagact    18900

tttctgcttg gtttatttat cttctctcag gagttgaact ctggaaattg aaactcacac    18960

cccctcttct aaattataat catagttttg taaaaagggc ttaccttaac tttgtagcaa    19020

atctgtactt tatggattgg caaaaatgag ctcaaataaa taacccaata gcaacgtcct    19080

ggtttatgct ggtcggtgga agattccaaa tttgttagga ttctggaagc agaaaacaga    19140

atcaagcaaa tcaagcggca tccagaggct ttgctgttaa aaaaaaaaaa ttaagtgctc    19200

tgggtagaaa aaataaagcc cccggttaga gcagagcaca ctaaaagaag aaaaccacga    19260

ttcttcgaat aatgaccaaa atgctctccc ctatcagagg gaatgaagac actctctggg    19320

tggcatttgt gcaacgcatg acgctatgct ggtggataaa aggccgggaa gaagttgaaa    19380

atggttttag tttaactgtc cacagccaga cctgggtcct gggcggcgtg gttttgatca    19440

aggtcagtct ttcattacct ctcttgcaca tcaagggaac gggcctctca cgtactcttc    19500

tcgcctgagc aaagtttaga tggcctaggg tagaaatggc aagtaattaa agacagagtc    19560

tatgggtttt ctgggatcct tcgaacaacg ccctcccacc ccgcccgcta ttccgcagct    19620

ccaccatagt gatttgtagc cgcggcgctg ggctctcctt gcagctgcct ctccttccag    19680

ggcggctgct tgtcgagcca agtgggagtg aggcgtgctt tttatagcag tcgggtgcaa    19740

agaggaaggg ggataaaaag gaaatcaaga atgaaaggaa aaagagaaaa agcggattac    19800

acggtctggg cccggcggag atgtgtaatg tgaaacatca ctggtgtcag ctcggatatc    19860

tcaggccagg cctctctcca atacacaaaa gccgccgtct ggggcgacag ggaggcccga    19920

tgtggattgg gatcggggtt gcggctgggc caccggacac gggtggaagc cggccggcgt    19980

gggtggccgc ctgcaaagcc aaacgacccg gctgggcctg gcgcgcggac aggcctgtgg    20040

tgggcttagg gtaaagaaga ggcagagcga aagaaggggg aatctccaaa actacccttt    20100

ccgggttccc ggagtttaat atgccaagct cctggagtta acgagctgac gaagaggtgg    20160

tcttttgctc tttatttggt tgttttgcta ggcgagaaag agtgttggcg gcctagtccc    20220

tgttaaggga gcacgtacca gggggtgggg gacgacagtg gaggtcaggg aaggaaggga    20280

ggaattgcgt gggagaaaga gcgatcctct agtgcccttc cagccccttc tcctcatccg    20340

tgggtctgtg gctttggaat ggaagcaagt ttgcaaggtg ccccgggaag ggttggaaaa    20400

gcctgctgcc ccgcgtttgt tttacattaa gtgtttttgg acctggagaa acgcctggct    20460

gagtgatcaa accgtccgca ggtctccatg cgttcggctg aggtttgtgg cgtagctccg    20520

agtcccagct cgcaggccag agcagaccag gtctcctgcg cttggtggag acccgggcca    20580

gtaactgaaa gctggccctg gtatcttggt gtgcagggcg gtgcagtgaa gcgaggccag    20640

ggtgtgtgag tgcgctagcg tgtgtgtcgg gggaaggcgg gggttggcct ccgatggaag    20700

ttttagtaat ctgcactgtg gcatctgttt gctcccttgc cccaaccgcc cccaggtttg    20760

gttcaagaat cgtcgggcca aatggagaaa gagggagcgc aaccagcagg ccgagctatg    20820

caagaatggc ttcgggccgc agttcaatgg gctcatgcag ccctacgacg acatgtaccc    20880

aggctattcc tacaacaact gggccgccaa gggccttaca tccgcctccc tatccaccaa    20940

gagcttcccc ttcttcaact ctatgaacgt caaccccctg tcatcacaga gcatgttttc    21000

cccacccaac tctatctcgt ccatgagcat gtcgtccagc atggtgccct cagcagtgac    21060

aggcgtcccg ggctccagtc tcaacagcct gaataacttg aacaacctga gtagcccgtc    21120

gctgaattcc gcggtgccga cgcctgcctg tccttacgcg ccgccgactc ctccgtatgt    21180

ttatagggac acgtgtaact cgagcctggc cagcctgaga ctgaaagcaa agcagcactc    21240

cagcttcggc tacgccagcg tgcagaaacc ggcctccaac ctgagtgctt gccagtatgc    21300

agtggaccgg cccgtgtgag ccgcacccac agcgccggga tcctaggacc ttgccggatg    21360

gggcaactcc gcccttgaaa gactgggaat tatgctagaa ggtcgtgggc actaaagaaa    21420

gggagagaaa gagaagctat atagagaaaa ggaaaccact gaatcaaaga gagagctcct    21480

ttgatttcaa agggatgtcc tcagtgtctg acatctttca ctacaagtat ttctaacagt    21540

tgcaaggaca catacacaaa caaatgtttt gactggatat gacattttaa cattactata    21600

agcttgttat tttttaagtt tagcattgtt aacatttaaa tgactgaaag gatgtatata    21660

tatcgaaatg tcaaattaat tttataaaag cagttgttag taatatcaca acagtgtttt    21720

taaaggttag gctttaaaat aaagcatgtt atacagaagc gattaggatt tttcgcttgc    21780

gagcaaggga gtgtatatac taaatgccac actgtatgtt tctaacatat tattattatt    21840

ataaaaaatg tgtgaatatc agttttagaa tagtttgtgt ggtggatgca atgatgtttc    21900

tgaaactgct atgtacaacc taccctgtgt ataacatttc gtacaatatt attgttttac    21960

ttttcagcaa atatgaaaca aatgtgtttt attttcatgg gagtaaaata tactgcatac    22020


<210>  3
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bisulfite-converted PITX 2 sequence with a fully methylated 
       status to which sequence a Taqman probe for methylated sequences 
       will bind

<400>  3
gtaggggagg gaagtagatg ttagcgggtc gaagagtcgg gagtcggagt cgggagagcg       60

aaaggagagg ggatttggcg gggtatttag gagttaatcg aggagtagga gtacggattt      120

ttattgtgga aaggaggatt agaa                                             144


<210>  4
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Bisulfite-converted PITX 2 sequence with an unmethylated status 
       to which sequence a Taqman probe for unmethylated sequences will 
       bind

<400>  4
gtaggggagg gaagtagatg ttagtgggtt gaagagttgg gagttggagt tgggagagtg       60

aaaggagagg ggatttggtg gggtatttag gagttaattg aggagtagga gtatggattt      120

ttattgtgga aaggaggatt agaa                                             144


<210>  5
<211>  144
<212>  DNA
<213>  Homo sapiens

<400>  5
gcaggggagg gaagcagatg ccagcgggcc gaagagtcgg gagccggagc cgggagagcg       60

aaaggagagg ggacctggcg gggcacttag gagccaaccg aggagcagga gcacggactc      120

ccactgtgga aaggaggacc agaa                                             144


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PITX2 reverse primer (PITX2-R)

<400>  6
ttctaatcct cctttccaca ataa                                              24


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PITX2 forward primer (PITX2-F)

<400>  7
gtaggggagg gaagtagatg tt                                                22


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PITX2 probe for methylated sequences (PITX2-Pm)

<400>  8
agtcggagtc gggagagcga                                                   20


<210>  9
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PITX2 probe for unmethylated sequences (PITX2-Pu)

<400>  9
agttggagtt gggagagtga aaggaga                                           27


