                         SEQUENCE LISTING

<110>  MAX-DELBRCK-CENTRUM FR MOLEKULARE MEDIZIN
       Humboldt-Universitt zu Berlin
 
<120>  CHIMERIC ANTIGEN RECEPTOR AND CAR-T CELLS THAT BIND BCMA

<130>  XII 2085/16WO

<150>  EP 16173401.7
<151>  2016-07-06

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  1

Gly Phe Thr Phe Ser Arg Tyr Trp 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  2

Ile Asn Pro Ser Ser Ser Thr Ile 
1               5               


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  3

Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr 
1               5                   10              


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  4

Gln Ser Val Glu Ser Asn 
1               5       


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Ser Ala Ser Xaa 
1               


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  6

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Ile Asn Pro Xaa Xaa Ser Thr Ile 
1               5               


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Ala Ser Leu Tyr Xaa Asp Tyr Gly Asp Ala Xaa Asp Tyr 
1               5                   10              


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Gln Ser Val Xaa Xaa Asn 
1               5       


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  10

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly 
1               5                   10      


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  12

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  13

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  14

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  15
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  15

Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys 
225                 230                 


<210>  16
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  16

Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Ser Leu Ser Pro Gly Lys Lys 
225                 230                 235 


<210>  17
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  17

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  18
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  18

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  19

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane

<400>  20

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  21
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transmembrane

<400>  21

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  22
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  22

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  23

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  24

Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
1               5                   10                  15      


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            20                  25                  30          


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        35                  40                  45              


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  25

Arg Tyr Trp Phe Ser 
1               5   


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  26

Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
1               5                   10                  15      


Asp Lys 
        


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  27

Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp 
1               5                   10              


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  28

Lys Ala Ser Gln Ser Val Glu Ser Asn Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  29

Ser Ala Ser Leu Arg Phe Ser 
1               5           


<210>  30
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  30

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr Phe Gly 
1               5                   10      


<210>  31
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu 
            20                  25                  30          


Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly 
        35                  40                  45              


Thr Asn Ala Leu Glu 
    50              


<210>  32
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Leu Glu 
    50                  55      


<210>  33
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  33

Tyr Phe Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys 
1               5                   10                  15      


Ser Ser Asn Thr 
            20  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Arg Tyr Trp Xaa Ser 
1               5   


<210>  35
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Glu Ile Asn Pro Xaa Xaa Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
1               5                   10                  15      


Asp Lys 
        


<210>  36
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Ser Leu Tyr Xaa Asp Tyr Gly Asp Ala Xaa Asp Tyr Trp 
1               5                   10              


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Lys Ala Ser Gln Ser Val Xaa Xaa Asn Val Ala 
1               5                   10      


<210>  38
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  mouse Ab

<400>  38

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Lys Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  39
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  40
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  41
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Xaa Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Xaa Xaa Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Xaa Asp Tyr Gly Asp Ala Xaa Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  42
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(101)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Xaa Met Xaa Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Xaa Val 
        35                  40                  45              


Gly Xaa Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Xaa Xaa Xaa Asp Tyr Gly Asp Xaa Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  44
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Asn Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  45
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  46
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  46

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  47
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  47

Asp Ile Val Met Thr Gln Ser Gln Arg Phe Met Thr Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Arg Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Phe Ser Ala Ser Leu Arg Phe Ser Gly Val Pro Ala Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  48
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  48

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Glu Val Thr Leu Thr Cys Lys Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Asp Asp Leu Arg Phe Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  49
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  49

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Asp Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  50
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  50

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Xaa Xaa Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  51
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  misc_feature
<222>  (31)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Asp Xaa Xaa 
            20                  25                  30          


Val Xaa Trp Xaa Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile 
        35                  40                  45              


Xaa Xaa Ala Xaa Xaa Arg Xaa Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Xaa Xaa Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Xaa Gln Xaa Asn Asn Xaa Pro Xaa 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  52
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  52

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  53
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (84)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa can be any naturally occurring amino acid

<400>  53

Xaa Val Gln Leu Xaa Xaa Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Xaa Leu Ser Cys Ala Ala Ser Gly Xaa Xaa Phe Xaa Xaa Tyr 
            20                  25                  30          


Trp Glx Ser Trp Val Arg Xaa Ala Pro Gly Lys Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Asn Pro Glx Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Xaa Xaa Phe Xaa Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Xaa Xaa Xaa Arg Xaa Glu Asp Thr Ala Xaa Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Glx Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Xaa Val Thr Val Ser Ser 
        115                 120 


<210>  54
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL


<220>
<221>  misc_feature
<222>  (8)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<400>  54

Asp Ile Val Met Thr Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa Ser Val Gly 
1               5                   10                  15      


Asp Xaa Val Xaa Xaa Thr Cys Lys Ala Ser Gln Ser Val Glu Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Xaa Gln Xaa Pro Lys Xaa Leu Ile 
        35                  40                  45              


Xaa Ser Xaa Xaa Leu Arg Phe Ser Gly Val Pro Ala Arg Phe Xaa Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Xaa Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Xaa Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  55
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader

<400>  55

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg 
            20      


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  leader

<400>  56

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile 
            20      


<210>  57
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  57

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
            500                 505                 510         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        515                 520                 525             


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    530                 535                 540                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
545                 550                 555                 560 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe 
                565                 570                 575     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            580                 585                 590         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        595                 600                 605             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    610                 615                 620                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
625                 630                 635                 640 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                645                 650                 655     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            660                 665                 670         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 


<210>  58
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  58

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln 
        35                  40                  45              


Ser Val Glu Ser Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Ala Leu Ile Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                165                 170                 175     


Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val 
            180                 185                 190         


Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro 
        195                 200                 205             


Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
            500                 505                 510         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        515                 520                 525             


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    530                 535                 540                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
545                 550                 555                 560 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe 
                565                 570                 575     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            580                 585                 590         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        595                 600                 605             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    610                 615                 620                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
625                 630                 635                 640 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                645                 650                 655     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            660                 665                 670         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 


<210>  59
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  59

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
            500                 505                 510         


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
        515                 520                 525             


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    530                 535                 540                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
545                 550                 555                 560 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe 
                565                 570                 575     


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
            580                 585                 590         


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
        595                 600                 605             


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
    610                 615                 620                 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
625                 630                 635                 640 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
                645                 650                 655     


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
            660                 665                 670         


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 


<210>  60
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  60

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Phe 
                485                 490                 495     


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
            500                 505                 510         


Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg 
        515                 520                 525             


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
    530                 535                 540                 


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
545                 550                 555                 560 


Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                565                 570                 575     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            580                 585                 590         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        595                 600                 605             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    610                 615                 620                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
625                 630                 635                 640 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                645                 650                 655     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            660                 665                 670         


Leu Pro Pro Arg 
        675     


<210>  61
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  61

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    370                 375                 380                 


Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
385                 390                 395                 400 


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
                405                 410                 415     


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
            420                 425                 430         


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
        435                 440                 445             


Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    450                 455                 460                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
465                 470                 475                 480 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                485                 490                 495     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            500                 505                 510         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        515                 520                 525             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    530                 535                 540                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
545                 550                 555                 560 


Gln Ala Leu Pro Pro Arg 
                565     


<210>  62
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  62

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
        275                 280                 285             


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    290                 295                 300                 


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
305                 310                 315                 320 


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
                325                 330                 335     


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Leu Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  63
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  63

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            500                 505                 510         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        515                 520                 525             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    530                 535                 540                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210>  64
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  64

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln 
        35                  40                  45              


Ser Val Glu Ser Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Ala Leu Ile Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
    130                 135                 140                 


Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                165                 170                 175     


Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val 
            180                 185                 190         


Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro 
        195                 200                 205             


Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            500                 505                 510         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        515                 520                 525             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    530                 535                 540                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210>  65
<211>  680
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  65

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Pro Ala Glu Pro Lys Ser 
            260                 265                 270         


Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Ser Leu 
                485                 490                 495     


Ser Pro Gly Lys Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
            500                 505                 510         


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
        515                 520                 525             


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
    530                 535                 540                 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Gly Cys Glu Leu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                565                 570                 575     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            580                 585                 590         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        595                 600                 605             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    610                 615                 620                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
625                 630                 635                 640 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                645                 650                 655     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            660                 665                 670         


His Met Gln Ala Leu Pro Pro Arg 
        675                 680 


<210>  66
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  66
gaggtgcagc tggtggaatc tggcggagga ctggtgcagc ctggcggctc tctgagactg       60

tcttgtgccg ccagcggctt caccttcagc cggtactggt ttagctgggt gcgccaggcc      120

cctggcaagg gactcgtgtg ggtgggagag atcaacccca gcagcagcac catcaactac      180

gcccccagcc tgaaggacaa gttcaccatc agcagagaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actattgtgc cagcctgtac      300

tacgactacg gcgacgccta cgattactgg ggccagggca cactggtgac tgttagctcc      360


<210>  67
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  67
gagatcgtga tgacacagag ccctgccacc ctgagcgtgt ccccaggcga aagagctacc       60

ctgagctgca aggccagcca gagcgtggaa agcaacgtgg cctggtatca gcagaagccc      120

ggacaggctc ctcgggccct gatctacagc gccagcctga gattcagcgg catccccgcc      180

aggtttagcg gctctggcag cggcaccgag ttcaccctga caatcagcag cctgcagagc      240

gaggactttg ccgtgtatta ctgccagcag tacaacaact accccctgac cttcggagcc      300

ggcaccaagc tggagctgaa g                                                321


<210>  68
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  68
gaagtgcagc tggtcgaatc tggaggaggc ctggttcagc ctggtggcag ccttaggctc       60

tcttgtgcag cctctggctt taccttctca cggtattggt tcagctgggt gagacaggct      120

ccagggaaag gtctggtgtg ggtaggggag ataaacccca gcagcagcac gatcaactat      180

gctccgtcac tgaaagacaa gttcaccatt tcccgcgata atgccaagaa cactctctac      240

ttgcagatga attcccttcg agccgaggat acagcggtgt actactgcgc cagtctgtac      300

tacgactatg gggacgcata cgactattgg ggacaaggca cactggtgac tgttagctcc      360


<210>  69
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  69
gagatcgtga tgacccagtc tcctgctacc ctgagcgttt ctcccggtga aagggccaca       60

ctcagctgca aagcctctca aagcgtggag agcaatgtcg cctggtatca gcagaaacct      120

ggccaagctc cgagagcact gatctattcc gcgtcattgc gcttttccgg cataccagca      180

cggtttagtg gctcagggag tgggactgag ttcactctga cgattagctc ccttcagtca      240

gaggatttcg ccgtgtacta ctgtcagcag tacaacaact atcccctcac attcggagct      300

ggaaccaagc tggaactgaa g                                                321


<210>  70
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader

<400>  70
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgc                                                                     63


<210>  71
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  leader

<400>  71
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atc                                                                     63


<210>  72
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  72
ggcagcacca gcggctccgg caagcctggc tctggcgagg gcagcacaaa ggga             54


<210>  73
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  linker

<400>  73
tctagcggcg gaggcggatc tggcggggga ggatctgggg gaggcggctc t                51


<210>  74
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  74
cctgccgagc ctaagagccc cgacaagacc cacacctgtc ccccttgtcc tgcccctcca       60

gtggctggcc ctagcgtgtt cctgttcccc ccaaagccca aggataccct gatgatcgcc      120

cggacccccg aagtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      480

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      540

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag      600

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac      660

cactacacgc agaagagcct ctccctgtct ccgggtaaaa aa                         702


<210>  75
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  75
cctgccgagc ctaagagccc cgacaagacc cacacctgtc ccccttgtcc tgcccctcca       60

gtggctggcc ctagcgtgtt cctgttcccc ccaaagccca aggataccct gatgatcgcc      120

cggacccccg aagtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      180

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      240

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      300

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      360

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      420

cgggatgagc tgaccaagaa ccaggtgtcc ctgacctgcc tcgtgaaggg cttctacccc      480

tccgatatcg ccgtggaatg ggagagcaat ggccagcccg agaacaacta caagaccacc      540

ccccctgtgc tggacagcga cggctcattc ttcctgtaca gcaagctgac agtggacaag      600

agccggtggc agcagggcaa cgtgttcagc tgcagcgtga tgcacgaggc tctgcacaac      660

cactacaccc agaagtccct gagcagcctg agcccaggca agaag                      705


<210>  76
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  76
gagagcaagt acggccctcc ctgcccccct tgccctgccc ccgagttcga gggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgcg tggtggtgga cgtgagccag gaagatcccg aggtccagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttcaacagc      240

acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa      300

tacaagtgca aggtgtccaa caagggcctg cccagcagca tcgaaaagac catcagcaag      360

gccaagggcc agcctcgcga gccccaggtg tacaccctgc ctccctccca ggaagagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg      540

gacagcgacg gcagcttctt cctctacagc cggctgaccg tggacaagag ccggtggcag      600

gaaggcaacg tctttagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaag                                          687


<210>  77
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  77
gagagcaagt acggccctcc ctgcccccct tgccctggcc agcctcgcga gccccaggtg       60

tacaccctgc ctccctccca ggaagagatg accaagaacc aggtgtccct gacctgcctg      120

gtgaagggct tctaccccag cgacatcgcc gtggagtggg agagcaacgg ccagcctgag      180

aacaactaca agaccacccc tcccgtgctg gacagcgacg gcagcttctt cctctacagc      240

cggctgaccg tggacaagag ccggtggcag gaaggcaacg tctttagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aagagcctga gcctgtccct gggcaag         357


<210>  78
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  78
gagagcaagt acggccctcc ctgcccccct tgccct                                 36


<210>  79
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane

<400>  79
atctacatct gggcccctct ggccggcacc tgtggcgtgc tgctgctgtc tctcgtgatc       60

acactgtact gc                                                           72


<210>  80
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transmembrane

<400>  80
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  81
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  81
aagcggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag       60

accacccagg aagaggacgg ctgctcctgc agattccccg aggaagaaga aggcggctgc      120

gagctg                                                                 126


<210>  82
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  82
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  83
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  83
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgtcgaccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  84
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  84
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag       60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt      120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgct ga                         342


<210>  85
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular

<400>  85
ctgcgcgtga agttttctag aagcgccgac gcccctgcct accagcaggg ccagaaccag       60

ctgtacaacg agctgaacct gggcagacgg gaagagtacg acgtgctgga taagcggaga      120

ggccgggacc ctgagatggg cggcaagcct agaagaaaga acccccagga aggcctgtat      180

aacgaactgc agaaagacaa gatggccgag gcctacagcg agatcggaat gaagggcgag      240

cggagaagag gcaagggcca cgatggactg taccagggcc tgagcaccgc caccaaggac      300

acctatgacg ccctgcacat gcaggctctg ccccccaga                             339


<210>  86
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  86
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaggtgc agctggtgga atctggcgga ggactggtgc agcctggcgg ctctctgaga      120

ctgtcttgtg ccgccagcgg cttcaccttc agccggtact ggtttagctg ggtgcgccag      180

gcccctggca agggactcgt gtgggtggga gagatcaacc ccagcagcag caccatcaac      240

tacgccccca gcctgaagga caagttcacc atcagcagag acaacgccaa gaacaccctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactattg tgccagcctg      360

tactacgact acggcgacgc ctacgattac tggggccagg gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cacagagccc tgccaccctg agcgtgtccc caggcgaaag agctaccctg      540

agctgcaagg ccagccagag cgtggaaagc aacgtggcct ggtatcagca gaagcccgga      600

caggctcctc gggccctgat ctacagcgcc agcctgagat tcagcggcat ccccgccagg      660

tttagcggct ctggcagcgg caccgagttc accctgacaa tcagcagcct gcagagcgag      720

gactttgccg tgtattactg ccagcagtac aacaactacc ccctgacctt cggagccggc      780

accaagctgg agctgaagcc tgccgagcct aagagccccg acaagaccca cacctgtccc      840

ccttgtcctg cccctccagt ggctggccct agcgtgttcc tgttcccccc aaagcccaag      900

gataccctga tgatcgcccg gacccccgaa gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaaaa     1500

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta     1560

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt     1620

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     1680

gccccaccac gcgacttcgc agcctatcgc tccctgagag tgaagttcag caggagcgca     1740

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1800

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1860

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1920

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1980

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     2040

ctgccccctc gctga                                                      2055


<210>  87
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  87
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgagatcg tgatgacaca gagccctgcc accctgagcg tgtccccagg cgaaagagct      120

accctgagct gcaaggccag ccagagcgtg gaaagcaacg tggcctggta tcagcagaag      180

cccggacagg ctcctcgggc cctgatctac agcgccagcc tgagattcag cggcatcccc      240

gccaggttta gcggctctgg cagcggcacc gagttcaccc tgacaatcag cagcctgcag      300

agcgaggact ttgccgtgta ttactgccag cagtacaaca actaccccct gaccttcgga      360

gccggcacca agctggagct gaagggcagc accagcggct ccggcaagcc tggctctggc      420

gagggcagca caaagggaga ggtgcagctg gtggaatctg gcggaggact ggtgcagcct      480

ggcggctctc tgagactgtc ttgtgccgcc agcggcttca ccttcagccg gtactggttt      540

agctgggtgc gccaggcccc tggcaaggga ctcgtgtggg tgggagagat caaccccagc      600

agcagcacca tcaactacgc ccccagcctg aaggacaagt tcaccatcag cagagacaac      660

gccaagaaca ccctgtacct gcagatgaac agcctgcggg ccgaggacac cgccgtgtac      720

tattgtgcca gcctgtacta cgactacggc gacgcctacg attactgggg ccagggcaca      780

ctggtgactg ttagctcccc tgccgagcct aagagccccg acaagaccca cacctgtccc      840

ccttgtcctg cccctccagt ggctggccct agcgtgttcc tgttcccccc aaagcccaag      900

gataccctga tgatcgcccg gacccccgaa gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaaaa     1500

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta     1560

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt     1620

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     1680

gccccaccac gcgacttcgc agcctatcgc tccctgagag tgaagttcag caggagcgca     1740

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1800

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1860

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1920

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1980

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     2040

ctgccccctc gctga                                                      2055


<210>  88
<211>  2055
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  88
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaagtgc agctggtcga atctggagga ggcctggttc agcctggtgg cagccttagg      120

ctctcttgtg cagcctctgg ctttaccttc tcacggtatt ggttcagctg ggtgagacag      180

gctccaggga aaggtctggt gtgggtaggg gagataaacc ccagcagcag cacgatcaac      240

tatgctccgt cactgaaaga caagttcacc atttcccgcg ataatgccaa gaacactctc      300

tacttgcaga tgaattccct tcgagccgag gatacagcgg tgtactactg cgccagtctg      360

tactacgact atggggacgc atacgactat tggggacaag gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cccagtctcc tgctaccctg agcgtttctc ccggtgaaag ggccacactc      540

agctgcaaag cctctcaaag cgtggagagc aatgtcgcct ggtatcagca gaaacctggc      600

caagctccga gagcactgat ctattccgcg tcattgcgct tttccggcat accagcacgg      660

tttagtggct cagggagtgg gactgagttc actctgacga ttagctccct tcagtcagag      720

gatttcgccg tgtactactg tcagcagtac aacaactatc ccctcacatt cggagctgga      780

accaagctgg aactgaagcc tgccgagcct aagagccccg acaagaccca cacctgtccc      840

ccttgtcctg cccctccagt ggctggccct agcgtgttcc tgttcccccc aaagcccaag      900

gataccctga tgatcgcccg gacccccgaa gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaaaaa     1500

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta     1560

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt     1620

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     1680

gccccaccac gcgacttcgc agcctatcgc tccctgagag tgaagttcag caggagcgca     1740

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1800

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1860

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1920

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1980

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     2040

ctgccccctc gctga                                                      2055


<210>  89
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  89
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaggtgc agctggtgga atctggcgga ggactggtgc agcctggcgg ctctctgaga      120

ctgtcttgtg ccgccagcgg cttcaccttc agccggtact ggtttagctg ggtgcgccag      180

gcccctggca agggactcgt gtgggtggga gagatcaacc ccagcagcag caccatcaac      240

tacgccccca gcctgaagga caagttcacc atcagcagag acaacgccaa gaacaccctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactattg tgccagcctg      360

tactacgact acggcgacgc ctacgattac tggggccagg gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cacagagccc tgccaccctg agcgtgtccc caggcgaaag agctaccctg      540

agctgcaagg ccagccagag cgtggaaagc aacgtggcct ggtatcagca gaagcccgga      600

caggctcctc gggccctgat ctacagcgcc agcctgagat tcagcggcat ccccgccagg      660

ttttccggat ctggcagcgg caccgagttc accctgacaa tcagcagcct gcagagcgag      720

gactttgccg tgtattactg ccagcagtac aacaactacc ccctgacctt cggagccggc      780

accaagctgg agctgaagga gagcaagtac ggccctccct gccccccttg ccctgccccc      840

gagttcgagg gcggacccag cgtgttcctg ttccccccca agcccaagga caccctgatg      900

atcagccgga cccccgaggt gacctgcgtg gtggtggacg tgagccagga agatcccgag      960

gtccagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga     1020

gaggaacagt tcaacagcac ctaccgggtg gtgtctgtgc tgaccgtgct gcaccaggac     1080

tggctgaacg gcaaagaata caagtgcaag gtgtccaaca agggcctgcc cagcagcatc     1140

gaaaagacca tcagcaaggc caagggccag cctcgcgagc cccaggtgta caccctgcct     1200

ccctcccagg aagagatgac caagaaccag gtgtccctga cctgcctggt gaagggcttc     1260

taccccagcg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1320

accacccctc ccgtgctgga cagcgacggc agcttcttcc tctacagccg gctgaccgtg     1380

gacaagagcc ggtggcagga aggcaacgtc tttagctgca gcgtgatgca cgaggccctg     1440

cacaaccact acacccagaa gagcctgagc ctgtccctgg gcaagttttg ggtgctggtg     1500

gtggttggtg gagtcctggc ttgctatagc ttgctagtaa cagtggcctt tattattttc     1560

tgggtgagga gtaagaggag caggctcctg cacagtgact acatgaacat gactccccgt     1620

cgacccgggc ccacccgcaa gcattaccag ccctatgccc caccacgcga cttcgcagcc     1680

tatcgctccc tgagagtgaa gttcagcagg agcgcagacg cccccgcgta ccagcagggc     1740

cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac     1800

aagagacgtg gccgggaccc tgagatgggg ggaaagccga gaaggaagaa ccctcaggaa     1860

ggcctgtaca atgaactgca gaaagataag atggcggagg cctacagtga gattgggatg     1920

aaaggcgagc gccggagggg caaggggcac gatggccttt accagggtct cagtacagcc     1980

accaaggaca cctacgacgc ccttcacatg caggccctgc cccctcgctg a              2031


<210>  90
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  90
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaggtgc agctggtgga atctggcgga ggactggtgc agcctggcgg ctctctgaga      120

ctgtcttgtg ccgccagcgg cttcaccttc agccggtact ggtttagctg ggtgcgccag      180

gcccctggca agggactcgt gtgggtggga gagatcaacc ccagcagcag caccatcaac      240

tacgccccca gcctgaagga caagttcacc atcagcagag acaacgccaa gaacaccctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactattg tgccagcctg      360

tactacgact acggcgacgc ctacgattac tggggccagg gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cacagagccc tgccaccctg agcgtgtccc caggcgaaag agctaccctg      540

agctgcaagg ccagccagag cgtggaaagc aacgtggcct ggtatcagca gaagcccgga      600

caggctcctc gggccctgat ctacagcgcc agcctgagat tcagcggcat ccccgccagg      660

ttttccggat ctggcagcgg caccgagttc accctgacaa tcagcagcct gcagagcgag      720

gactttgccg tgtattactg ccagcagtac aacaactacc ccctgacctt cggagccggc      780

accaagctgg agctgaagga gagcaagtac ggccctccct gccccccttg ccctggccag      840

cctcgcgagc cccaggtgta caccctgcct ccctcccagg aagagatgac caagaaccag      900

gtgtccctga cctgcctggt gaagggcttc taccccagcg acatcgccgt ggagtgggag      960

agcaacggcc agcctgagaa caactacaag accacccctc ccgtgctgga cagcgacggc     1020

agcttcttcc tctacagccg gctgaccgtg gacaagagcc ggtggcagga aggcaacgtc     1080

tttagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc     1140

ctgtccctgg gcaagttttg ggtgctggtg gtggttggtg gagtcctggc ttgctatagc     1200

ttgctagtaa cagtggcctt tattattttc tgggtgagga gtaagaggag caggctcctg     1260

cacagtgact acatgaacat gactccccgt cgacccgggc ccacccgcaa gcattaccag     1320

ccctatgccc caccacgcga cttcgcagcc tatcgctccc tgagagtgaa gttcagcagg     1380

agcgcagacg cccccgcgta ccagcagggc cagaaccagc tctataacga gctcaatcta     1440

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1500

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1560

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1620

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1680

caggccctgc cccctcgctg a                                               1701


<210>  91
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  91
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaggtgc agctggtgga atctggcgga ggactggtgc agcctggcgg ctctctgaga      120

ctgtcttgtg ccgccagcgg cttcaccttc agccggtact ggtttagctg ggtgcgccag      180

gcccctggca agggactcgt gtgggtggga gagatcaacc ccagcagcag caccatcaac      240

tacgccccca gcctgaagga caagttcacc atcagcagag acaacgccaa gaacaccctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactattg tgccagcctg      360

tactacgact acggcgacgc ctacgattac tggggccagg gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cacagagccc tgccaccctg agcgtgtccc caggcgaaag agctaccctg      540

agctgcaagg ccagccagag cgtggaaagc aacgtggcct ggtatcagca gaagcccgga      600

caggctcctc gggccctgat ctacagcgcc agcctgagat tcagcggcat ccccgccagg      660

ttttccggat ctggcagcgg caccgagttc accctgacaa tcagcagcct gcagagcgag      720

gactttgccg tgtattactg ccagcagtac aacaactacc ccctgacctt cggagccggc      780

accaagctgg agctgaagga gagcaagtac ggccctccct gccccccttg ccctttttgg      840

gtgctggtgg tggttggtgg agtcctggct tgctatagct tgctagtaac agtggccttt      900

attattttct gggtgaggag taagaggagc aggctcctgc acagtgacta catgaacatg      960

actccccgtc gacccgggcc cacccgcaag cattaccagc cctatgcccc accacgcgac     1020

ttcgcagcct atcgctccct gagagtgaag ttcagcagga gcgcagacgc ccccgcgtac     1080

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat     1140

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1200

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1260

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1320

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgctga     1380


<210>  92
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  92
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaggtgc agctggtgga atctggcgga ggactggtgc agcctggcgg ctctctgaga      120

ctgtcttgtg ccgccagcgg cttcaccttc agccggtact ggtttagctg ggtgcgccag      180

gcccctggca agggactcgt gtgggtggga gagatcaacc ccagcagcag caccatcaac      240

tacgccccca gcctgaagga caagttcacc atcagcagag acaacgccaa gaacaccctg      300

tacctgcaga tgaacagcct gcgggccgag gacaccgccg tgtactattg tgccagcctg      360

tactacgact acggcgacgc ctacgattac tggggccagg gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cacagagccc tgccaccctg agcgtgtccc caggcgaaag agctaccctg      540

agctgcaagg ccagccagag cgtggaaagc aacgtggcct ggtatcagca gaagcccgga      600

caggctcctc gggccctgat ctacagcgcc agcctgagat tcagcggcat ccccgccagg      660

tttagcggct ctggcagcgg caccgagttc accctgacaa tcagcagcct gcagagcgag      720

gactttgccg tgtattactg ccagcagtac aacaactacc ccctgacctt cggagccggc      780

accaagctgg agctgaagcc tgccgagcct aagagccccg acaagaccca cacctgtccc      840

ccttgtcctg cccctccagt ggctggccct agcgtgttcc tgttcccccc aaagcccaag      900

gataccctga tgatcgcccg gacccccgaa gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtgtccct gacctgcctc     1260

gtgaagggct tctacccctc cgatatcgcc gtggaatggg agagcaatgg ccagcccgag     1320

aacaactaca agaccacccc ccctgtgctg gacagcgacg gctcattctt cctgtacagc     1380

aagctgacag tggacaagag ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1440

cacgaggctc tgcacaacca ctacacccag aagtccctga gcagcctgag cccaggcaag     1500

aagatctaca tctgggcccc tctggccggc acctgtggcg tgctgctgct gtctctcgtg     1560

atcacactgt actgcaagcg gggcagaaag aagctgctgt acatcttcaa gcagcccttc     1620

atgcggcccg tgcagaccac ccaggaagag gacggctgct cctgcagatt ccccgaggaa     1680

gaagaaggcg gctgcgagct gctgcgcgtg aagttttcta gaagcgccga cgcccctgcc     1740

taccagcagg gccagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac     1800

gacgtgctgg ataagcggag aggccgggac cctgagatgg gcggcaagcc tagaagaaag     1860

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1920

gagatcggaa tgaagggcga gcggagaaga ggcaagggcc acgatggact gtaccagggc     1980

ctgagcaccg ccaccaagga cacctatgac gccctgcaca tgcaggctct gccccccaga     2040


<210>  93
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  93
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgagatcg tgatgacaca gagccctgcc accctgagcg tgtccccagg cgaaagagct      120

accctgagct gcaaggccag ccagagcgtg gaaagcaacg tggcctggta tcagcagaag      180

cccggacagg ctcctcgggc cctgatctac agcgccagcc tgagattcag cggcatcccc      240

gccaggttta gcggctctgg cagcggcacc gagttcaccc tgacaatcag cagcctgcag      300

agcgaggact ttgccgtgta ttactgccag cagtacaaca actaccccct gaccttcgga      360

gccggcacca agctggagct gaagggcagc accagcggct ccggcaagcc tggctctggc      420

gagggcagca caaagggaga ggtgcagctg gtggaatctg gcggaggact ggtgcagcct      480

ggcggctctc tgagactgtc ttgtgccgcc agcggcttca ccttcagccg gtactggttt      540

agctgggtgc gccaggcccc tggcaaggga ctcgtgtggg tgggagagat caaccccagc      600

agcagcacca tcaactacgc ccccagcctg aaggacaagt tcaccatcag cagagacaac      660

gccaagaaca ccctgtacct gcagatgaac agcctgcggg ccgaggacac cgccgtgtac      720

tattgtgcca gcctgtacta cgactacggc gacgcctacg attactgggg ccagggcaca      780

ctggtgactg ttagctcccc tgccgagcct aagagccccg acaagaccca cacctgtccc      840

ccttgtcctg cccctccagt ggctggccct agcgtgttcc tgttcccccc aaagcccaag      900

gataccctga tgatcgcccg gacccccgaa gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtgtccct gacctgcctc     1260

gtgaagggct tctacccctc cgatatcgcc gtggaatggg agagcaatgg ccagcccgag     1320

aacaactaca agaccacccc ccctgtgctg gacagcgacg gctcattctt cctgtacagc     1380

aagctgacag tggacaagag ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1440

cacgaggctc tgcacaacca ctacacccag aagtccctga gcagcctgag cccaggcaag     1500

aagatctaca tctgggcccc tctggccggc acctgtggcg tgctgctgct gtctctcgtg     1560

atcacactgt actgcaagcg gggcagaaag aagctgctgt acatcttcaa gcagcccttc     1620

atgcggcccg tgcagaccac ccaggaagag gacggctgct cctgcagatt ccccgaggaa     1680

gaagaaggcg gctgcgagct gctgcgcgtg aagttttcta gaagcgccga cgcccctgcc     1740

taccagcagg gccagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac     1800

gacgtgctgg ataagcggag aggccgggac cctgagatgg gcggcaagcc tagaagaaag     1860

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1920

gagatcggaa tgaagggcga gcggagaaga ggcaagggcc acgatggact gtaccagggc     1980

ctgagcaccg ccaccaagga cacctatgac gccctgcaca tgcaggctct gccccccaga     2040


<210>  94
<211>  2040
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  94
atggatttcc aggtgcagat cttcagcttc ctgctgatct ccgccagcgt gatcatgagc       60

cgcgaagtgc agctggtcga atctggagga ggcctggttc agcctggtgg cagccttagg      120

ctctcttgtg cagcctctgg ctttaccttc tcacggtatt ggttcagctg ggtgagacag      180

gctccaggga aaggtctggt gtgggtaggg gagataaacc ccagcagcag cacgatcaac      240

tatgctccgt cactgaaaga caagttcacc atttcccgcg ataatgccaa gaacactctc      300

tacttgcaga tgaattccct tcgagccgag gatacagcgg tgtactactg cgccagtctg      360

tactacgact atggggacgc atacgactat tggggacaag gcacactggt gactgttagc      420

tccggcagca ccagcggctc cggcaagcct ggctctggcg agggcagcac aaagggagag      480

atcgtgatga cccagtctcc tgctaccctg agcgtttctc ccggtgaaag ggccacactc      540

agctgcaaag cctctcaaag cgtggagagc aatgtcgcct ggtatcagca gaaacctggc      600

caagctccga gagcactgat ctattccgcg tcattgcgct tttccggcat accagcacgg      660

tttagtggct cagggagtgg gactgagttc actctgacga ttagctccct tcagtcagag      720

gatttcgccg tgtactactg tcagcagtac aacaactatc ccctcacatt cggagctgga      780

accaagctgg aactgaagcc tgccgagcct aagagccccg acaagaccca cacctgtccc      840

ccttgtcctg cccctccagt ggctggccct agcgtgttcc tgttcccccc aaagcccaag      900

gataccctga tgatcgcccg gacccccgaa gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtgtccct gacctgcctc     1260

gtgaagggct tctacccctc cgatatcgcc gtggaatggg agagcaatgg ccagcccgag     1320

aacaactaca agaccacccc ccctgtgctg gacagcgacg gctcattctt cctgtacagc     1380

aagctgacag tggacaagag ccggtggcag cagggcaacg tgttcagctg cagcgtgatg     1440

cacgaggctc tgcacaacca ctacacccag aagtccctga gcagcctgag cccaggcaag     1500

aagatctaca tctgggcccc tctggccggc acctgtggcg tgctgctgct gtctctcgtg     1560

atcacactgt actgcaagcg gggcagaaag aagctgctgt acatcttcaa gcagcccttc     1620

atgcggcccg tgcagaccac ccaggaagag gacggctgct cctgcagatt ccccgaggaa     1680

gaagaaggcg gctgcgagct gctgcgcgtg aagttttcta gaagcgccga cgcccctgcc     1740

taccagcagg gccagaacca gctgtacaac gagctgaacc tgggcagacg ggaagagtac     1800

gacgtgctgg ataagcggag aggccgggac cctgagatgg gcggcaagcc tagaagaaag     1860

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1920

gagatcggaa tgaagggcga gcggagaaga ggcaagggcc acgatggact gtaccagggc     1980

ctgagcaccg ccaccaagga cacctatgac gccctgcaca tgcaggctct gccccccaga     2040


