                         SEQUENCE LISTING

<110>  Deutsches Krebsforschungszentrum Stiftung des oeffentlichen
        Rechts
 
<120>  The core domain of annexins and uses thereof in antigen delivery 
       and vaccination

<130>  D31523WO

<150>  EP16173925.5
<151>  2016-06-10

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  2
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  3
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asn Arg His Ala Lys Ala Ser Ser Pro Gln Gly Phe Asp Val 
1               5                   10                  15      


Asp Arg Asp Ala Lys Lys Leu Asn Lys Ala Cys Lys Gly Met Gly Thr 
            20                  25                  30          


Asn Glu Ala Ala Ile Ile Glu Ile Leu Ser Gly Arg Thr Ser Asp Glu 
        35                  40                  45              


Arg Gln Gln Ile Lys Gln Lys Tyr Lys Ala Thr Tyr Gly Lys Glu Leu 
    50                  55                  60                  


Glu Glu Val Leu Lys Ser Glu Leu Ser Gly Asn Phe Glu Lys Thr Ala 
65                  70                  75                  80  


Leu Ala Leu Leu Asp His Pro Ser Glu Tyr Ala Ala Arg Gln Leu Gln 
                85                  90                  95      


Lys Ala Met Lys Gly Leu Gly Thr Asp Glu Ser Val Leu Ile Glu Val 
            100                 105                 110         


Leu Cys Thr Arg Thr Asn Lys Glu Ile Ile Ala Ile Lys Glu Ala Tyr 
        115                 120                 125             


Gln Arg Leu Phe Asp Arg Ser Leu Glu Ser Asp Val Lys Gly Asp Thr 
    130                 135                 140                 


Ser Gly Asn Leu Lys Lys Ile Leu Val Ser Leu Leu Gln Ala Asn Arg 
145                 150                 155                 160 


Asn Glu Gly Asp Asp Val Asp Lys Asp Leu Ala Gly Gln Asp Ala Lys 
                165                 170                 175     


Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu Ala 
            180                 185                 190         


Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala Thr 
        195                 200                 205             


Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Ile Glu Glu Ala Ile 
    210                 215                 220                 


Glu Glu Glu Thr Ser Gly Asp Leu Gln Lys Ala Tyr Leu Thr Leu Val 
225                 230                 235                 240 


Arg Cys Ala Gln Asp Cys Glu Asp Tyr Phe Ala Glu Arg Leu Tyr Lys 
                245                 250                 255     


Ser Met Lys Gly Ala Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile Ile 
            260                 265                 270         


Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe Gln 
        275                 280                 285             


Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val Arg Ser Asp Thr Ser 
    290                 295                 300                 


Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
305                 310                 315     


<210>  4
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  4

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  5
<211>  17
<212>  PRT
<213>  Gallus gallus

<400>  5

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210>  6
<211>  346
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Arg Phe Leu Glu Asn 
1               5                   10                  15      


Gln Glu Gln Glu Tyr Val Gln Ala Val Lys Ser Tyr Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Ser Phe Asn Val Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Thr Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Asn Gly Lys Pro Leu Asp Glu Val Leu 
                85                  90                  95      


Arg Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Met Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Gly Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Thr Thr Arg 
    130                 135                 140                 


Ser Asn Glu Gln Ile Arg Glu Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Lys Ala Leu Leu Ala Leu Ala Lys Gly Asp Arg Cys Gln Asp Leu 
            180                 185                 190         


Ser Val Asn Gln Asp Leu Ala Asp Thr Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Thr Thr Ile 
    210                 215                 220                 


Leu Thr Ser Arg Ser Phe Pro His Leu Arg Arg Val Phe Gln Asn Tyr 
225                 230                 235                 240 


Gly Lys Tyr Ser Gln His Asp Met Asn Lys Ala Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Thr Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Thr Pro Ala Phe Phe Ala Glu Lys Leu Tyr Glu Ala Met Lys Gly 
        275                 280                 285             


Ala Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Glu Ile Lys Val Phe Tyr Gln Lys Lys Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  7
<211>  319
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ala Thr Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp Gly Arg 
1               5                   10                  15      


Ala Asp Ala Glu Val Leu Arg Lys Ala Met Lys Gly Leu Gly Thr Asp 
            20                  25                  30          


Glu Asp Ser Ile Leu Asn Leu Leu Thr Ser Arg Ser Asn Ala Gln Arg 
        35                  40                  45              


Gln Glu Ile Ala Gln Glu Phe Lys Thr Leu Phe Gly Arg Asp Leu Val 
    50                  55                  60                  


Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu Ile Val 
65                  70                  75                  80  


Ala Met Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu Lys His 
                85                  90                  95      


Ala Leu Lys Gly Ala Gly Thr Asp Glu Lys Val Leu Thr Glu Ile Ile 
            100                 105                 110         


Ala Ser Arg Thr Pro Glu Glu Leu Ser Ala Ile Lys Gln Val Tyr Glu 
        115                 120                 125             


Glu Glu Tyr Gly Ser Asn Leu Glu Asp Asp Val Val Gly Asp Thr Ser 
    130                 135                 140                 


Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn Arg Asp 
145                 150                 155                 160 


Pro Asp Thr Ala Ile Asp Asp Ala Gln Val Glu Leu Asp Ala Gln Ala 
                165                 170                 175     


Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu Lys Phe 
            180                 185                 190         


Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Arg Val Phe 
        195                 200                 205             


Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr Ile Asp 
    210                 215                 220                 


Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val Val Lys 
225                 230                 235                 240 


Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr Tyr Ala 
                245                 250                 255     


Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val Val Val 
            260                 265                 270         


Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe Arg Lys 
        275                 280                 285             


Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr Ser Gly 
    290                 295                 300                 


Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Gly Glu Asp Asp 
305                 310                 315                 


<210>  8
<211>  317
<212>  PRT
<213>  Mus musculus

<400>  8

Met Gly Asn Arg His Ala Lys Glu Arg Ser His His His Gly Phe Asp 
1               5                   10                  15      


Ala Asp Arg Asp Ala Lys Lys Leu Tyr Lys Ala Cys Lys Gly Met Gly 
            20                  25                  30          


Thr Asp Glu Ala Ala Ile Ile Glu Val Leu Ser Ser Arg Thr Ser Glu 
        35                  40                  45              


Glu Arg Gln Gln Ile Lys Gln Lys Tyr Lys Glu Lys Tyr Gly Lys Asp 
    50                  55                  60                  


Leu Glu Glu Val Leu Asn Ser Glu Leu Ser Gly Asn Phe Lys Lys Thr 
65                  70                  75                  80  


Ala Leu Ala Leu Leu Asp Arg Pro Asn Glu Tyr Ala Ala Arg Gln Leu 
                85                  90                  95      


Gln Lys Ala Met Lys Gly Val Gly Thr Asp Glu Ala Met Leu Ile Glu 
            100                 105                 110         


Ile Leu Cys Thr Arg Ser Asn Lys Glu Ile Val Ala Ile Lys Glu Ala 
        115                 120                 125             


Tyr Gln Arg Leu Phe Gly Arg Ser Leu Glu Ser Asp Val Lys Glu Asp 
    130                 135                 140                 


Thr Ser Gly Asn Leu Arg Lys Ile Leu Val Ser Leu Leu Gln Ala Ser 
145                 150                 155                 160 


Arg Asp Glu Glu Asp Thr Val Asp Lys Glu Leu Ala Gly Gln Asp Ala 
                165                 170                 175     


Lys Asp Leu Tyr Asp Ala Gly Glu Gly Arg Trp Gly Thr Asp Glu Leu 
            180                 185                 190         


Ala Phe Asn Glu Val Leu Ala Lys Arg Ser Tyr Lys Gln Leu Arg Ala 
        195                 200                 205             


Thr Phe Gln Ala Tyr Gln Ile Leu Ile Gly Lys Asp Met Glu Glu Thr 
    210                 215                 220                 


Ile Glu Glu Glu Thr Ser Gly Asp Leu Lys Lys Ala Tyr Leu Thr Ile 
225                 230                 235                 240 


Val Arg Cys Ala Gln Asp Leu Glu Gly Tyr Phe Ala Asp Leu Leu Tyr 
                245                 250                 255     


Lys Ala Met Lys Gly Met Gly Thr Asp Glu Glu Thr Leu Ile Arg Ile 
            260                 265                 270         


Ile Val Thr Arg Ala Glu Val Asp Leu Gln Gly Ile Lys Ala Lys Phe 
        275                 280                 285             


Gln Glu Lys Tyr Gln Lys Ser Leu Ser Asp Met Val His Ser Asp Thr 
    290                 295                 300                 


Ser Gly Asp Phe Arg Lys Leu Leu Val Ala Leu Leu His 
305                 310                 315         


<210>  9
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  9
ggcggaggtt caggcggagg ttcagatcaa gccagagagc tcatc                       45


<210>  10
<211>  37
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  10
gaaaacttgt atttccaggg cggcggaggt tcaggcg                                37


<210>  11
<211>  53
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  11
ggatccggcg gaggttcagg cggaggttca gaaaacttgt atttccaggg cgg              53


<210>  12
<211>  28
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  12
ggatccaggg gaaacacatc tgccaaag                                          28


<210>  13
<211>  1724
<212>  DNA
<213>  Artificial

<220>
<223>  Fusion Protein

<400>  13
atgaatccat cctcggatgt cgctgccttg cataaggcca taatggttaa aggtgtggat       60

gaggcaacca tcattgacat tctaactaag cgaaacaatg cacagcgtca acagatcaaa      120

gcagcattct ccaggaaaca ggaaagcccc tggatgaaac actgaagaaa gcccttacag      180

gtcaccttga ggaggttgtt ttagctctgc taaaaactcc agcgcaattt gatgctgatg      240

aacttcgtgc tgcctgaagg gccttggaac tgatgaagat actctaattg agattttggc      300

atcaagaact aacaaagaaa tcagagacat taacagggtc tacagagagg aactgaagag      360

agatctggcc aaagacataa ctcagacaca tctggagatt ttcggaacgc tttgctttct      420

cttgctaagg gtgaccgatc tgaggacttt ggtgtgaatg aagacttggc tgattcagat      480

gccagggcct tgtatgaagc aggagaaaga gaaaggggac agacgtaaac gtgttcaata      540

ccatccttac caccagaagc tatccacaac ttcgcagagt gtttcagaaa tacaccaagt      600

acagtaagca tgacatgaac aaagttctgg acctgagttg aaaggtgaca ttgagaaatg      660

cctcacagct atcgtgaagt gcgccacaag caaaccagct ttctttgcag agaagcttca      720

tcaagccatg aaaggtgttg gaactcgcca taaggcattg ataggattat ggtttcccgt      780

tctgaaattg acatgaatga tatcaaagca ttctatcaga agatgtatgg tatctccctt      840

tgccaagcca tcctggatga aaccaaagga gattatgaga aaatcctggg gctctttgtg      900

gaggaaacca tcggggatcc ggcggaggtt caggcggagg ttcagaaaac ttgtatttcc      960

agggcggcgg aggttcaggc ggaggttcga tcaagccaga gagctcatca attcctgggt     1020

agaaagtcag acaaatggaa ttatcagaaa tgtccttcag ccaagctccg tggattctca     1080

aactgcaatg gttctggtta atgccattgt cttcaaggac tgtgggagaa agcatttaag     1140

gatgaagaca cacaagcaat gcctttcaga gtgactgagc aagaaagcaa acctgtgcag     1200

atgatgtacc agattggttt atttagagtg gcatcaatgg ctctgagaaa atgaagatcc     1260

tggagcttcc atttgccagt gggacaatga gcatgttggt gctgttgcct gatgaagtct     1320

caggccttga gcagcttgag agtataatca actttgaaaa actgactgat ggaccagttc     1380

taatgttatg gaagagagga agatcaaagt gtacttacct cgcatgaaga tggaggaaaa     1440

atacaacctc acatctgtct taatggctat gggcattact gacgtgttta gctcttagcc     1500

aatctgtctg gcatctcctc agcagagagc ctgaagatat ctcaagctgt ccatgcagca     1560

catgcagaaa tcaatgaagc aggcagagag gtggtagggt cagcagaggc tggagtggat     1620

gctcaagcgt ctctgaagaa tttagggctg accatccatt cctcttctgt atcaagcaca     1680

tcgcaaccaa cgccgttctc ttctttggca gatgtgtttc ccct                      1724


<210>  14
<211>  576
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion Protein

<400>  14

Met Asn Pro Ser Ser Asp Val Ala Ala Leu His Lys Ala Ile Met Val 
1               5                   10                  15      


Lys Gly Val Asp Glu Ala Thr Ile Ile Asp Ile Leu Thr Lys Arg Asn 
            20                  25                  30          


Asn Ala Gln Arg Gln Gln Ile Lys Ala Ala Tyr Leu Gln Glu Thr Gly 
        35                  40                  45              


Lys Pro Leu Asp Glu Thr Leu Lys Lys Ala Leu Thr Gly His Leu Glu 
    50                  55                  60                  


Glu Val Val Leu Ala Leu Leu Lys Thr Pro Ala Gln Phe Asp Ala Asp 
65                  70                  75                  80  


Glu Leu Arg Ala Ala Met Lys Gly Leu Gly Thr Asp Glu Asp Thr Leu 
                85                  90                  95      


Ile Glu Ile Leu Ala Ser Arg Thr Asn Lys Glu Ile Arg Asp Ile Asn 
            100                 105                 110         


Arg Val Tyr Arg Glu Glu Leu Lys Arg Asp Leu Ala Lys Asp Ile Ser 
        115                 120                 125             


Asp Thr Ser Gly Asp Phe Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly 
    130                 135                 140                 


Asp Arg Ser Glu Asp Phe Gly Val Asn Glu Asp Leu Ala Asp Ser Asp 
145                 150                 155                 160 


Ala Arg Ala Leu Tyr Glu Ala Gly Glu Arg Arg Lys Gly Thr Asp Val 
                165                 170                 175     


Asn Val Phe Asn Thr Ile Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg 
            180                 185                 190         


Arg Val Phe Gln Lys Tyr Thr Lys Tyr Ser Lys His Asp Met Asn Lys 
        195                 200                 205             


Val Leu Asp Leu Glu Leu Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala 
    210                 215                 220                 


Ile Val Lys Cys Ala Thr Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu 
225                 230                 235                 240 


His Gln Ala Met Lys Gly Val Gly Thr Arg His Lys Ala Leu Arg Ile 
                245                 250                 255     


Met Val Ser Arg Ser Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr 
            260                 265                 270         


Gln Lys Met Tyr Gly Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr 
        275                 280                 285             


Lys Gly Asp Tyr Glu Lys Ile Leu Val Ala Leu Cys Gly Gly Asn His 
    290                 295                 300                 


Arg Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Asn Leu Tyr Phe 
305                 310                 315                 320 


Gln Gly Gly Gly Gly Ser Gly Gly Gly Ser Asp Gln Ala Arg Glu Leu 
                325                 330                 335     


Ile Asn Ser Trp Val Glu Ser Gln Thr Asn Gly Ile Ile Arg Asn Val 
            340                 345                 350         


Leu Gln Pro Ser Ser Val Asp Ser Gln Thr Ala Met Val Leu Val Asn 
        355                 360                 365             


Ala Ile Val Phe Lys Gly Leu Trp Glu Lys Ala Phe Lys Asp Glu Asp 
    370                 375                 380                 


Thr Gln Ala Met Pro Phe Arg Val Thr Glu Gln Glu Ser Lys Pro Val 
385                 390                 395                 400 


Gln Met Met Tyr Gln Ile Gly Leu Phe Arg Val Ala Ser Met Ala Ser 
                405                 410                 415     


Glu Lys Met Lys Ile Leu Glu Leu Pro Phe Ala Ser Gly Thr Met Ser 
            420                 425                 430         


Met Leu Val Leu Leu Pro Asp Glu Val Ser Gly Leu Glu Gln Leu Glu 
        435                 440                 445             


Ser Ile Ile Asn Phe Glu Lys Leu Thr Trp Thr Ser Ser Asn Val Met 
    450                 455                 460                 


Glu Glu Arg Lys Ile Lys Val Tyr Leu Pro Arg Met Lys Met Glu Glu 
465                 470                 475                 480 


Lys Tyr Asn Leu Thr Ser Val Leu Met Ala Met Gly Ile Thr Asp Val 
                485                 490                 495     


Phe Ser Ser Ser Ala Asn Leu Ser Gly Ile Ser Ser Ala Glu Ser Leu 
            500                 505                 510         


Lys Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala 
        515                 520                 525             


Gly Arg Glu Val Val Gly Ser Ala Glu Ala Gly Val Asp Ala Ala Ser 
    530                 535                 540                 


Val Ser Glu Glu Phe Arg Ala Asp His Pro Phe Leu Phe Cys Ile Lys 
545                 550                 555                 560 


His Ile Ala Thr Asn Ala Val Leu Phe Phe Gly Arg Cys Val Ser Pro 
                565                 570                 575     


<210>  15
<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  linker sequence

<400>  15

His Arg Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25          


