               SEQUENCE LISTING

<110> Christian-Albrechts-Universität zu Kiel

<120> Wirkstoffe gegen Protozoen

<130> K1027PCT

<150> EP16173828.1
<151> 2016-06-09

<160> 6

<170> BiSSAP 1.3.6

<210> 1
<211> 309
<212> PRT
<213> Plasmodium falciparum


<220> 
<223> PfFNT_PF3D7_0316600_PlasmoDB

<400> 1
Met Pro Pro Asn Asn Ser Lys Tyr Val Leu Asp Pro Val Ser Ile Lys 
1               5                   10                  15      
Ser Val Cys Gly Gly Glu Glu Ser Tyr Ile Arg Cys Val Glu Tyr Gly 
            20                  25                  30          
Lys Lys Lys Ala His Tyr Ser Asn Leu Asn Leu Leu Ala Lys Ala Ile 
        35                  40                  45              
Leu Ala Gly Met Phe Val Gly Leu Cys Ala His Ala Ser Gly Ile Ala 
    50                  55                  60                  
Gly Gly Leu Phe Tyr Tyr His Lys Leu Arg Glu Ile Val Gly Ala Ser 
65                  70                  75                  80  
Met Ser Val Phe Val Tyr Gly Phe Thr Phe Pro Ile Ala Phe Met Cys 
                85                  90                  95      
Ile Ile Cys Thr Gly Ser Asp Leu Phe Thr Gly Asn Thr Leu Ala Val 
            100                 105                 110         
Thr Met Ala Leu Tyr Glu Lys Lys Val Lys Leu Leu Asp Tyr Leu Arg 
        115                 120                 125             
Val Met Thr Ile Ser Leu Phe Gly Asn Tyr Val Gly Ala Val Ser Phe 
    130                 135                 140                 
Ala Phe Phe Val Ser Tyr Leu Ser Gly Ala Phe Thr Asn Val His Ala 
145                 150                 155                 160 
Val Glu Lys Asn His Phe Phe Gln Phe Leu Asn Asp Ile Ala Glu Lys 
                165                 170                 175     
Lys Val His His Thr Phe Val Glu Cys Val Ser Leu Ala Val Gly Cys 
            180                 185                 190         
Asn Ile Phe Val Cys Leu Ala Val Tyr Phe Val Leu Thr Leu Lys Asp 
        195                 200                 205             
Gly Ala Gly Tyr Val Phe Ser Val Phe Phe Ala Val Tyr Ala Phe Ala 
    210                 215                 220                 
Ile Ala Gly Tyr Glu His Ile Ile Ala Asn Ile Tyr Thr Leu Asn Ile 
225                 230                 235                 240 
Ala Leu Met Val Asn Thr Lys Ile Thr Val Tyr Gln Ala Tyr Ile Lys 
                245                 250                 255     
Asn Leu Leu Pro Thr Leu Leu Gly Asn Tyr Ile Ala Gly Ala Ile Val 
            260                 265                 270         
Leu Gly Leu Pro Leu Tyr Phe Ile Tyr Lys Glu His Tyr Tyr Asn Phe 
        275                 280                 285             
Glu Arg Ser Lys Arg Asp Asn Asn Asp Ala Gln Met Lys Ser Leu Ser 
    290                 295                 300                 
Ile Glu Leu Arg Asn 
305                 

<210> 2
<211> 412
<212> PRT
<213> Toxoplasma gondii


<220> 
<223> TgFNT1_TGGT1_209800_ToxoDB

<400> 2
Met Val Val Thr Ala Ser Pro Asp Thr Tyr Leu His Val Ile Asp Tyr 
1               5                   10                  15      
Gly Leu Lys Lys Val Arg Leu Arg Phe Asp Arg Leu Leu Leu Gln Ala 
            20                  25                  30          
Phe Met Ala Gly Val Tyr Ile Gly Met Ala Gly Asn Ala Cys Ile Ser 
        35                  40                  45              
Leu Ala Gly Gly Phe Ser Thr Asp Pro Ala Asp Pro Lys Ala Ile Thr 
    50                  55                  60                  
Ala Gly Val Gln Lys Phe Ile Tyr Ala Ser Ile Phe Pro Val Ala Phe 
65                  70                  75                  80  
Ile Ala Ile Ile Met Thr Gly Ala Glu Leu Phe Thr Gly Asn Thr Met 
                85                  90                  95      
Thr Met Leu Ile Cys Trp Phe Glu Arg Arg Ile Thr Ile Trp Gln Leu 
            100                 105                 110         
Leu Gln Asn Trp Ala Gly Ser Phe Leu Gly Asn Trp Leu Gly Thr Met 
        115                 120                 125             
Phe Ser Ala Tyr Phe Leu Thr Tyr Leu Cys Cys Pro Phe Asp His Asp 
    130                 135                 140                 
Pro Tyr Leu Ser Tyr Leu Asn Tyr Thr Ala Ala Ser Lys Val Ser Tyr 
145                 150                 155                 160 
Gly Trp Gly Ser Cys Phe Leu Arg Gly Val Gly Cys Asn Thr Trp Val 
                165                 170                 175     
Cys Leu Ala Val Trp Phe Val Val Ala Cys Asp Asp Ala Ala Gly Lys 
            180                 185                 190         
Ile Leu Ala Leu Trp Phe Pro Ile Val Ala Phe Val Leu Ser Ser Tyr 
        195                 200                 205             
Glu His Ile Ile Ala Asn Leu Tyr Thr Leu Gln Leu Cys Ala Met Leu 
    210                 215                 220                 
Gly Val Asp Thr Ser Leu Ala Asp Met Ile Ala Phe Asn Leu Leu Pro 
225                 230                 235                 240 
Thr Leu Leu Gly Asn Leu Phe Gly Gly Cys Gly Leu Ile Gly Met Val 
                245                 250                 255     
Tyr Phe Tyr Asn Phe Tyr Pro Val Val Gly His Gly Asp Asp Ala Ala 
            260                 265                 270         
Glu Gly Ser Ile Cys Gly Ser Ser Glu Lys Glu Glu Cys Pro Ser Leu 
        275                 280                 285             
Val Gly Val Pro Arg Gly Ala Ser Val Asn Ser Leu Ala Val Ser Ala 
    290                 295                 300                 
Ile Pro Ser Val Phe Ser Ala Pro Arg Gly Gln Arg Glu Ser Phe Ala 
305                 310                 315                 320 
Gly Glu Ser Ser Thr Leu Val Met Gly Asp Ile Lys Arg Gln Arg Ser 
                325                 330                 335     
Met Ala Ser Thr Arg Lys Leu Gly Gly Gly Ala Asp Lys Lys Asp Val 
            340                 345                 350         
Gln Leu Thr Val Arg Gln Phe Asp Glu Thr Glu Met Gln Ser Thr Met 
        355                 360                 365             
Glu Asp Met Phe Gly Leu Glu Asp Pro Arg Asn Ala Pro Lys Gly Asn 
    370                 375                 380                 
Pro Gly Thr Asn Pro Pro Ser Lys Ser Pro Glu Ser Ser Ala Thr Gly 
385                 390                 395                 400 
Gly Thr Gly Ala Ala Ala Ser Pro Thr Ala Thr Ser 
                405                 410         

<210> 3
<211> 463
<212> PRT
<213> Toxoplasma gondii


<220> 
<223> TgFNT3_TGGT1_292110_ToxoDB

<400> 3
Met Cys Ser Ile Pro Pro Leu Arg Leu Leu Glu Val Val Asp Asp Leu 
1               5                   10                  15      
Thr Cys Leu Val Asn Ser Ser Gln Tyr Ser Arg Trp Asp Phe Phe Thr 
            20                  25                  30          
Phe Thr Leu Pro Gly Ser Thr Leu Pro Met Arg Lys Glu Phe Thr Ser 
        35                  40                  45              
Ser Cys Lys Gly Ser Phe Ser Asn His Pro Val Pro Asp His Pro Cys 
    50                  55                  60                  
Lys Leu Val Val Phe Val Arg Pro Lys Met Val Val Thr Ala Gly Ala 
65                  70                  75                  80  
Asp Ala Tyr Leu Lys Ile Leu Glu Tyr Gly Val Lys Lys Thr Gln Leu 
                85                  90                  95      
Arg Ile Asp Arg Leu Leu Leu Gln Ala Phe Met Ala Gly Ile Phe Val 
            100                 105                 110         
Ala Met Ala Gly His Cys Cys Thr Val Leu Ala Gly Ser Tyr Pro Thr 
        115                 120                 125             
Asp Pro Gly Asp Pro Leu Ala Val Ala Lys Pro Thr Gln Lys Phe Ile 
    130                 135                 140                 
Tyr Gly Ala Leu Phe Pro Val Ala Phe Ile Cys Ile Ile Leu Thr Gly 
145                 150                 155                 160 
Ala Glu Leu Phe Thr Gly Asn Thr Met Thr Met Leu Ile Cys Tyr Phe 
                165                 170                 175     
Gln Lys Arg Val Thr Met Leu Gln Leu Gly Val Asn Trp Leu Gly Ser 
            180                 185                 190         
Leu Ala Gly Asn Trp Leu Gly Ala Leu Phe Gly Ala Tyr Phe Leu Ser 
        195                 200                 205             
Tyr Leu Thr Gly Ala Leu Gly Asp Glu His Val Arg Gln Phe Leu Phe 
    210                 215                 220                 
Arg Thr Cys Val Asn Lys Ile Ser Tyr Gly Trp Gly Glu Cys Phe Leu 
225                 230                 235                 240 
Arg Gly Val Gly Cys Asn Thr Phe Val Cys Leu Ala Val Trp Ala Val 
                245                 250                 255     
Ile Ala Ser Glu Asn Val Ala Gly Lys Val Leu Val Met Trp Phe Pro 
            260                 265                 270         
Ile Val Ala Phe Cys Val Gly Gly Tyr Glu His Ile Ile Ala Asn Met 
        275                 280                 285             
Tyr Thr Leu Gln Ala Gly Leu Met Ala Gly Ala Pro Val Ala Ile Leu 
    290                 295                 300                 
Asp Val Ile Ala Phe Asn Phe Leu Pro Thr Leu Leu Gly Asn Ile Val 
305                 310                 315                 320 
Gly Gly Cys Leu Leu Val Gly Ala Val Tyr Ala Tyr Asn Phe Tyr Pro 
                325                 330                 335     
Thr Leu Ser Tyr Thr Glu Thr Thr Gly Ala Lys Val Tyr Val Gln Glu 
            340                 345                 350         
Val Gly Pro Val Leu Asp Arg Arg Ser Ser Met Gln Val Ser Met Thr 
        355                 360                 365             
Glu Arg Glu Pro Asp Gly Gln Val Val Thr Glu Tyr Glu Ala Val Pro 
    370                 375                 380                 
Phe Glu Ser Phe Gly Gly Glu Tyr Ile Val Asn Lys His Ala Thr Met 
385                 390                 395                 400 
Ala Ala Pro Ile Pro Ser Arg Ala Ser Ser Phe Leu Tyr Pro Phe Gln 
                405                 410                 415     
Trp Gln Arg Gln Arg Ser Gln Ser Gly Asn Leu Ser Thr His Ala Arg 
            420                 425                 430         
Leu Asp Leu Pro Asn Arg Pro Val Glu Pro Pro Ser Asp Gly Leu Glu 
        435                 440                 445             
Val Thr Pro Gln Ser Gln Thr Ala Glu Ser Val Ala Gln Gln Val 
    450                 455                 460             

<210> 4
<211> 501
<212> PRT
<213> Toxoplasma gondii


<220> 
<223> TgFNT2_TGGT1_229170_ToxoDB

<400> 4
Met Val Leu Ala Ala Ser Pro Glu Ala Tyr Arg Lys Val Ile Glu Tyr 
1               5                   10                  15      
Gly Ile Lys Lys Thr Lys Leu Arg Ile Asp Arg Leu Phe Leu Gln Ala 
            20                  25                  30          
Ile Met Ala Gly Ile Tyr Val Gly Met Ala Gly His Ala Cys Thr Ala 
        35                  40                  45              
Leu Ala Gly Ala Tyr Ser Thr Asp Pro Ala Asn Pro Leu Ala Val Ser 
    50                  55                  60                  
Lys Ala Thr Gln Lys Phe Leu Tyr Ala Ser Leu Phe Pro Val Ala Phe 
65                  70                  75                  80  
Ile Ala Ile Ile Phe Thr Gly Ala Glu Leu Phe Thr Gly Asn Thr Met 
                85                  90                  95      
Thr Met Leu Val Cys Leu Leu Glu Arg Arg Val Thr Ala Leu Gln Leu 
            100                 105                 110         
Cys Ile Asn Trp Ile Cys Ser Leu Val Gly Asn Trp Ala Gly Ala Leu 
        115                 120                 125             
Phe Ala Ala Tyr Phe Leu Ser Tyr Leu Pro Gly Val Leu Gln Asp Pro 
    130                 135                 140                 
Asp His Leu His Tyr Leu Glu Asp Val Ala Ala His Lys Thr Glu Leu 
145                 150                 155                 160 
Ser Phe Leu Gln Cys Phe Cys Leu Ala Val Gly Cys Asn Thr Phe Val 
                165                 170                 175     
Cys Leu Ala Val Trp Phe Val Ile Ala Ser Asp Asp Ala Ala Gly Lys 
            180                 185                 190         
Ile Met Ser Met Trp Phe Pro Ile Val Ser Phe Cys Val Ala Gly Tyr 
        195                 200                 205             
Glu His Ile Ile Ala Asn Phe Tyr Thr Leu Gln Cys Ala Leu Met His 
    210                 215                 220                 
Gly Val Gly Pro Gly Val Gly Thr Val Ile Leu Lys Asn Phe Ile Pro 
225                 230                 235                 240 
Thr Leu Leu Gly Asn Ile Val Gly Gly Cys Gly Leu Val Gly Ala Val 
                245                 250                 255     
Tyr Trp Tyr Asn Phe Tyr Pro Thr Val Cys Val Val Gln Glu Ala Arg 
            260                 265                 270         
Gln Pro Leu Pro Leu Ser Glu Asn Ala Pro Ser Ser Thr Arg Gln Val 
        275                 280                 285             
Val Ala Asp Leu Phe Ser Leu Trp Gly Arg Glu Ser Ser Thr Pro Gly 
    290                 295                 300                 
Val Ser Ala Ser Pro Pro Asp Ala Ala Thr Asn Ala Gly Cys Ser Ala 
305                 310                 315                 320 
Leu Asp Pro Pro Arg Asn Ala Leu Leu Ala Ala Gly Lys Asn Phe Gly 
                325                 330                 335     
Asn Leu Ser Ala Gly Asp Arg Gly Ala Leu Ala Glu Gly Ile Pro Gly 
            340                 345                 350         
Gly Ala Cys Glu Asp Cys Leu Leu Val Pro Arg Ala Ser Phe Gly Gly 
        355                 360                 365             
Glu Tyr His Pro Pro Gln Gln Gly Asp Ala Gly Arg Trp Cys Lys Pro 
    370                 375                 380                 
Ser Lys Ala Ala Val Gly Ser Gly Gly Val Leu Cys His Val Gln Ser 
385                 390                 395                 400 
Pro Ala Ala Leu Glu Ala Val Ser Asn Ser Pro Leu Arg Glu Asn Ser 
                405                 410                 415     
Gly Val Pro Ser Gly Gly Leu Leu Leu Cys Glu Gly Arg Val Arg Arg 
            420                 425                 430         
Ser Ser Arg Glu Arg Glu Pro Glu Arg Gly Gly Glu Glu Glu Glu Gly 
        435                 440                 445             
Ala Ser Pro Glu Glu Glu His Pro Ala Val Thr Leu Ser Ile Pro Pro 
    450                 455                 460                 
Thr Asp Phe His Pro His Val Pro Arg Glu Val Glu Gln Ser Ser Leu 
465                 470                 475                 480 
Leu Glu Glu Thr Arg Val Ala Ala Glu Asn Ser Ala Leu Glu Glu His 
                485                 490                 495     
Pro Ala Ser Thr Ile 
            500     

<210> 5
<211> 356
<212> PRT
<213> Entamoeba histolytica


<220> 
<223> EhFNT_EHI_198990_AmoebaDB

<400> 5
Met Pro Arg Glu Lys Pro Arg Ala Asp Glu Ile Ala Ile Glu Met Met 
1               5                   10                  15      
Ser Val Cys Glu Asp Glu Thr Glu Val Glu Gln Asp Pro Arg Glu Leu 
            20                  25                  30          
Tyr Glu Glu Glu Met Lys Glu Gln Gln Gln Ile Asp Cys Ser Lys Gln 
        35                  40                  45              
Gln Lys Glu Val Val Ala Ile Glu Glu Leu Glu Lys Arg Asn Ile Asn 
    50                  55                  60                  
Lys His Phe Phe Ser Ile Gln Pro Asn Thr Gln Ile Pro Val Ile Ser 
65                  70                  75                  80  
Ser Asn Tyr Ile Ala Pro Val Asp Thr Ser Arg Leu Leu Val Leu Ile 
                85                  90                  95      
Gly Lys Thr Lys Ala Thr Tyr Pro Ile Met Lys Met Phe Ser Leu Ser 
            100                 105                 110         
Val Leu Ala Gly Met Leu Leu Ser Val Gly Gly Leu Leu Ser Ile Thr 
        115                 120                 125             
Ile Gly Lys Gly Ile Pro Ser Ser Asp Ile Gly Ile Gln Lys Ile Val 
    130                 135                 140                 
Phe Gly Phe Phe Asn Ser Val Gly Leu Asn Leu Val Val Leu Cys Gly 
145                 150                 155                 160 
Gly Glu Leu Phe Thr Ser Asn Cys Ala Phe Leu Ile Pro Gly Phe Met 
                165                 170                 175     
Glu Gly Ala Tyr Ser Arg Trp Leu Phe Phe Lys Thr His Phe Val Val 
            180                 185                 190         
Tyr Phe Gly Asn Leu Val Gly Ser Ile Phe Val Ser Thr Tyr Phe Gly 
        195                 200                 205             
Lys Leu Leu Gly Ser Phe Glu Ser Pro Met Tyr Leu Ser Ala Val Lys 
    210                 215                 220                 
Gln Ile Gly Glu Thr Lys Val Ala Met Asn Trp Gly Arg Ala Leu Leu 
225                 230                 235                 240 
Ser Gly Ile Gly Cys Asn Trp Leu Val Cys Cys Ala Val Tyr Phe Ser 
                245                 250                 255     
Ala Ser Ala Lys Asp Leu Leu Ser Lys Leu Val Val Ile Ser Phe Leu 
            260                 265                 270         
Val Leu Thr Phe Ala Ser Leu Glu Phe Glu Asn Cys Val Gly Asn Met 
        275                 280                 285             
Phe Leu Leu Ser Leu Ser His Met Tyr Gly Gly Asn Phe Thr Leu Gly 
    290                 295                 300                 
Gln Trp Ile Leu Asn Asn Leu Ile Pro Val Ser Ile Gly Asn Phe Ile 
305                 310                 315                 320 
Gly Gly Thr Phe Leu Leu Gly Ile Pro Leu Trp Tyr Val His Val Ser 
                325                 330                 335     
Asn Val Tyr Asn Ile Pro Phe Leu Asp Pro Leu Tyr Gln Gln Ser Gln 
            340                 345                 350         
Ala Lys Thr Gln 
        355     

<210> 6
<211> 269
<212> PRT
<213> Salmonella enterica subsp. enterica serovar Typhimurium


<220> 
<223> StNirC_AAA27040_NCBI

<400> 6
Met Phe Thr Asp Ser Ile Asn Lys Cys Ala Ala Lys Leu Arg Ala Ser 
1               5                   10                  15      
Ala Pro Val Ser Ala Asn Asn Pro Leu Gly Phe Trp Val Ser Ser Ala 
            20                  25                  30          
Met Ala Gly Ala Tyr Val Gly Leu Gly Ile Ile Leu Ile Phe Thr Leu 
        35                  40                  45              
Gly Asn Leu Leu Asp Pro Ser Val Arg Pro Leu Val Met Gly Ala Thr 
    50                  55                  60                  
Phe Gly Ile Ala Leu Thr Leu Val Ile Ile Ala Gly Ser Glu Leu Phe 
65                  70                  75                  80  
Thr Gly His Thr Met Phe Leu Thr Leu Gly Val Lys Ala Gly Thr Ile 
                85                  90                  95      
Ser His Gly Gln Met Trp Ala Ile Leu Pro Gln Thr Trp Leu Gly Asn 
            100                 105                 110         
Leu Val Gly Ser Val Phe Val Ala Leu Leu Tyr Ser Trp Gly Gly Gly 
        115                 120                 125             
Ser Leu Leu Pro Val Asp Thr Ser Ile Val His Ser Val Ala Leu Ala 
    130                 135                 140                 
Lys Thr Thr Ala Pro Ala Thr Val Leu Phe Phe Lys Gly Ala Leu Cys 
145                 150                 155                 160 
Asn Trp Leu Val Cys Leu Ala Ile Trp Met Ala Ile Arg Thr Glu Gly 
                165                 170                 175     
Thr Ala Lys Phe Leu Ala Ile Trp Trp Cys Leu Leu Ala Phe Ile Ala 
            180                 185                 190         
Ser Gly Tyr Glu His Ser Val Ala Asn Met Thr Leu Phe Ala Leu Ser 
        195                 200                 205             
Trp Phe Gly His His Ser Asp Ala Tyr Thr Leu Ala Gly Ile Gly His 
    210                 215                 220                 
Asn Leu Leu Trp Val Thr Leu Gly Asn Thr Leu Ser Gly Val Val Phe 
225                 230                 235                 240 
Met Gly Leu Gly Tyr Trp Tyr Ala Thr Pro Lys Ser Glu Arg Pro Ala 
                245                 250                 255     
Pro Ala Lys Ile Asn Gln Pro Glu Ala Ala Ala Asn Asn 
            260                 265                 

