                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Texas System
 
<120>  INHIBITORY RNA-BASED THERAPEUTICS TARGETING ANLN FOR CANCER 
       TREATMENT

<130>  UTFD.P3076WO

<140>  Not Yet Assigned
<141>  2017-05-24

<150>  62/347,803
<151>  2016-06-09

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  1
ggcucucugc agauacuaat t                                                 21


<210>  2
<211>  4804
<212>  DNA
<213>  Homo sapiens

<400>  2
cccagcgcgc atgctcgcgg ctcggcgctg aaattcaaat ttgaacggct gcagaggccg       60

agtccgtcac tggaagccga gaggagagga cagctggttg tgggagagtt cccccgcctc      120

agactcctgg ttttttccag gagacacact gagctgagac tcacttttct cttcctgaat      180

ttgaaccacc gtttccatcg tctcgtagtc cgacgcctgg ggcgatggat ccgtttacgg      240

agaaactgct ggagcgaacc cgtgccaggc gagagaatct tcagagaaaa atggctgaga      300

ggcccacagc agctccaagg tctatgactc atgctaagcg agctagacag ccactttcag      360

aagcaagtaa ccagcagccc ctctctggtg gtgaagagaa atcttgtaca aaaccatcgc      420

catcaaaaaa acgctgttct gacaacactg aagtagaagt ttctaacttg gaaaataaac      480

aaccagttga gtcgacatct gcaaaatctt gttctccaag tcctgtgtct cctcaggtgc      540

agccacaagc agcagatacc atcagtgatt ctgttgctgt cccggcatca ctgctgggca      600

tgaggagagg gctgaactca agattggaag caactgcagc ctcctcagtt aaaacacgta      660

tgcaaaaact tgcagagcaa cggcgccgtt gggataatga tgatatgaca gatgacattc      720

ctgaaagctc actcttctca ccaatgccat cagaggaaaa ggctgcttcc cctcccagac      780

ctctgctttc aaatgcctcg gcaactccag ttggcagaag gggccgtctg gccaatcttg      840

ctgcaactat ttgctcctgg gaagatgatg taaatcactc atttgcaaaa caaaacagtg      900

tacaagaaca gcctggtacc gcttgtttat ccaaattttc ctctgcaagt ggagcatctg      960

ctaggatcaa tagcagcagt gttaagcagg aagctacatt ctgttcccaa agggatggcg     1020

atgcctcttt gaataaagcc ctatcctcaa gtgctgatga tgcgtctttg gttaatgcct     1080

caatttccag ctctgtgaaa gctacttctc cagtgaaatc tactacatct atcactgatg     1140

ctaaaagttg tgagggacaa aatcctgagc tacttccaaa aactcctatt agtcctctga     1200

aaacgggggt atcgaaacca attgtgaagt caactttatc ccagacagtt ccatccaagg     1260

gagaattaag tagagaaatt tgtctgcaat ctcaatctaa agacaaatct acgacaccag     1320

gaggaacagg aattaagcct ttcctggaac gctttggaga gcgttgtcaa gaacatagca     1380

aagaaagtcc agctcgtagc acaccccaca gaacccccat tattactcca aatacaaagg     1440

ccatccaaga aagattattc aagcaagaca catcttcatc tactacccat ttagcacaac     1500

agctcaagca ggaacgtcaa aaagaactag catgtcttcg tggccgattt gacaagggca     1560

atatatggag tgcagaaaaa ggcggaaact caaaaagcaa acaactagaa accaaacagg     1620

aaactcactg tcagagcact cccctcaaaa aacaccaagg tgtttcaaaa actcagtcac     1680

ttccagtaac agaaaaggtg accgaaaacc agataccagc caaaaattct agtacagaac     1740

ctaaaggttt cactgaatgc gaaatgacga aatctagccc tttgaaaata acattgtttt     1800

tagaagagga caaatcctta aaagtaacat cagacccaaa ggttgagcag aaaattgaag     1860

tgatacgtga aattgagatg agtgtggatg atgatgatat caatagttcg aaagtaatta     1920

atgacctctt cagtgatgtc ctagaggaag gtgaactaga tatggagaag agccaagagg     1980

agatggatca agcattagca gaaagcagcg aagaacagga agatgcactg aatatctcct     2040

caatgtcttt acttgcacca ttggcacaaa cagttggtgt ggtaagtcca gagagtttag     2100

tgtccacacc tagactggaa ttgaaagaca ccagcagaag tgatgaaagt ccaaaaccag     2160

gaaaattcca aagaactcgt gtccctcgag ctgaatctgg tgatagcctt ggttctgaag     2220

atcgtgatct tctttacagc attgatgcat atagatctca aagattcaaa gaaacagaac     2280

gtccatcaat aaagcaggtg attgttcgga aggaagatgt tacttcaaaa ctggatgaaa     2340

aaaataatgc ctttccttgt caagttaata tcaaacagaa aatgcaggaa ctcaataacg     2400

aaataaatat gcaacagaca gtgatctatc aagctagcca ggctcttaac tgctgtgttg     2460

atgaagaaca tggaaaaggg tccctagaag aagctgaagc agaaagactt cttctaattg     2520

caactgggaa gagaacactt ttgattgatg aattgaataa attgaagaac gaaggacctc     2580

agaggaagaa taaggctagt ccccaaagtg aatttatgcc atccaaagga tcagttactt     2640

tgtcagaaat ccgcttgcct ctaaaagcag attttgtctg cagtacggtt cagaaaccag     2700

atgcagcaaa ttactattac ttaattatac taaaagcagg agctgaaaat atggtagcca     2760

caccattagc aagtacttca aactctctta acggtgatgc tctgacattc actactacat     2820

ttactctgca agatgtatcc aatgactttg aaataaatat tgaagtttac agcttggtgc     2880

aaaagaaaga tccctcaggc cttgataaga agaaaaaaac atccaagtcc aaggctatta     2940

ctccaaagcg actcctcaca tctataacca caaaaagcaa cattcattct tcagtcatgg     3000

ccagtccagg aggtcttagt gctgtgcgaa ccagcaactt cgcccttgtt ggatcttaca     3060

cattatcatt gtcttcagta ggaaatacta agtttgttct ggacaaggtc ccctttttat     3120

cttctttgga aggtcatatt tatttaaaaa taaaatgtca agtgaattcc agtgttgaag     3180

aaagaggttt tctaaccata tttgaagatg ttagtggttt tggtgcctgg catcgaagat     3240

ggtgtgttct ttctggaaac tgtatatctt attggactta tccagatgat gagaaacgca     3300

agaatcccat aggaaggata aatctggcta attgtaccag tcgtcagata gaaccagcca     3360

acagagaatt ttgtgcaaga cgcaacactt ttgaattaat tactgtccga ccacaaagag     3420

aagatgaccg agagactctt gtcagccaat gcagggacac actctgtgtt accaagaact     3480

ggctgtctgc agatactaaa gaagagcggg atctctggat gcaaaaactc aatcaagttc     3540

ttgttgatat tcgcctctgg caacctgatg cttgctacaa acctattgga aagccttaaa     3600

ccgggaaatt tccatgctat ctagaggttt ttgatgtcat cttaagaaac acacttaaga     3660

gcatcagatt tactgattgc attttatgct ttaagtacga aagggtttgt gccaatattc     3720

actacgtatt atgcagtatt tatatctttt gtatgtaaaa ctttaactga tttctgtcat     3780

tcatcaatga gtagaagtaa atacattata gttgattttg ctaaatctta atttaaaagc     3840

ctcattttcc tagaaatcta attattcagt tattcatgac aatatttttt taaaagtaag     3900

aaattctgag ttgtcttctt ggagctgtag gtcttgaagc agcaacgtct ttcaggggtt     3960

ggagacagaa acccattctc caatctcagt agttttttcg aaaggctgtg atcatttatt     4020

gatcgtgata tgacttgtta ctagggtact gaaaaaaatg tctaaggcct ttacagaaac     4080

atttttagta atgaggatga gaactttttc aaatagcaaa tatatattgg cttaaagcat     4140

gaggctgtct tcagaaaagt gatgtggaca taggaggcaa tgtgtgagac ttgggggttc     4200

aatattttat atagaagagt taataagcac atggtttaca tttactcagc tactatatat     4260

gcagtgtggt gcacattttc acagaattct ggcttcatta agatcattat ttttgctgcg     4320

tagcttacag acttagcata ttagtttttt ctactcctac aagtgtaaat tgaaaaatct     4380

ttatattaaa aaagtaaact gttatgaagc tgctatgtac taataatact ttgcttgcca     4440

aagtgtttgg gttttgttgt tgtttgtttg tttgtttgtt tttggttcat gaacaacagt     4500

gtctagaaac ccattttgaa agtggaaaat tattaagtca cctatcacct ttaaacgcct     4560

ttttttaaaa ttataaaata ttgtaaagca gggtctcaac ttttaaatac actttgaact     4620

tcttctctga attattaaag ttctttatga cctcatttat aaacactaaa ttctgtcacc     4680

tcctgtcatt ttatttttta ttcattcaaa tgtatttttt cttgtgcata ttataaaaat     4740

atattttatg agctcttact caaataaata cctgtaaatg tctaaaggaa aaaaaaaaaa     4800

aaaa                                                                  4804


<210>  3
<211>  1124
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Pro Phe Thr Glu Lys Leu Leu Glu Arg Thr Arg Ala Arg Arg 
1               5                   10                  15      


Glu Asn Leu Gln Arg Lys Met Ala Glu Arg Pro Thr Ala Ala Pro Arg 
            20                  25                  30          


Ser Met Thr His Ala Lys Arg Ala Arg Gln Pro Leu Ser Glu Ala Ser 
        35                  40                  45              


Asn Gln Gln Pro Leu Ser Gly Gly Glu Glu Lys Ser Cys Thr Lys Pro 
    50                  55                  60                  


Ser Pro Ser Lys Lys Arg Cys Ser Asp Asn Thr Glu Val Glu Val Ser 
65                  70                  75                  80  


Asn Leu Glu Asn Lys Gln Pro Val Glu Ser Thr Ser Ala Lys Ser Cys 
                85                  90                  95      


Ser Pro Ser Pro Val Ser Pro Gln Val Gln Pro Gln Ala Ala Asp Thr 
            100                 105                 110         


Ile Ser Asp Ser Val Ala Val Pro Ala Ser Leu Leu Gly Met Arg Arg 
        115                 120                 125             


Gly Leu Asn Ser Arg Leu Glu Ala Thr Ala Ala Ser Ser Val Lys Thr 
    130                 135                 140                 


Arg Met Gln Lys Leu Ala Glu Gln Arg Arg Arg Trp Asp Asn Asp Asp 
145                 150                 155                 160 


Met Thr Asp Asp Ile Pro Glu Ser Ser Leu Phe Ser Pro Met Pro Ser 
                165                 170                 175     


Glu Glu Lys Ala Ala Ser Pro Pro Arg Pro Leu Leu Ser Asn Ala Ser 
            180                 185                 190         


Ala Thr Pro Val Gly Arg Arg Gly Arg Leu Ala Asn Leu Ala Ala Thr 
        195                 200                 205             


Ile Cys Ser Trp Glu Asp Asp Val Asn His Ser Phe Ala Lys Gln Asn 
    210                 215                 220                 


Ser Val Gln Glu Gln Pro Gly Thr Ala Cys Leu Ser Lys Phe Ser Ser 
225                 230                 235                 240 


Ala Ser Gly Ala Ser Ala Arg Ile Asn Ser Ser Ser Val Lys Gln Glu 
                245                 250                 255     


Ala Thr Phe Cys Ser Gln Arg Asp Gly Asp Ala Ser Leu Asn Lys Ala 
            260                 265                 270         


Leu Ser Ser Ser Ala Asp Asp Ala Ser Leu Val Asn Ala Ser Ile Ser 
        275                 280                 285             


Ser Ser Val Lys Ala Thr Ser Pro Val Lys Ser Thr Thr Ser Ile Thr 
    290                 295                 300                 


Asp Ala Lys Ser Cys Glu Gly Gln Asn Pro Glu Leu Leu Pro Lys Thr 
305                 310                 315                 320 


Pro Ile Ser Pro Leu Lys Thr Gly Val Ser Lys Pro Ile Val Lys Ser 
                325                 330                 335     


Thr Leu Ser Gln Thr Val Pro Ser Lys Gly Glu Leu Ser Arg Glu Ile 
            340                 345                 350         


Cys Leu Gln Ser Gln Ser Lys Asp Lys Ser Thr Thr Pro Gly Gly Thr 
        355                 360                 365             


Gly Ile Lys Pro Phe Leu Glu Arg Phe Gly Glu Arg Cys Gln Glu His 
    370                 375                 380                 


Ser Lys Glu Ser Pro Ala Arg Ser Thr Pro His Arg Thr Pro Ile Ile 
385                 390                 395                 400 


Thr Pro Asn Thr Lys Ala Ile Gln Glu Arg Leu Phe Lys Gln Asp Thr 
                405                 410                 415     


Ser Ser Ser Thr Thr His Leu Ala Gln Gln Leu Lys Gln Glu Arg Gln 
            420                 425                 430         


Lys Glu Leu Ala Cys Leu Arg Gly Arg Phe Asp Lys Gly Asn Ile Trp 
        435                 440                 445             


Ser Ala Glu Lys Gly Gly Asn Ser Lys Ser Lys Gln Leu Glu Thr Lys 
    450                 455                 460                 


Gln Glu Thr His Cys Gln Ser Thr Pro Leu Lys Lys His Gln Gly Val 
465                 470                 475                 480 


Ser Lys Thr Gln Ser Leu Pro Val Thr Glu Lys Val Thr Glu Asn Gln 
                485                 490                 495     


Ile Pro Ala Lys Asn Ser Ser Thr Glu Pro Lys Gly Phe Thr Glu Cys 
            500                 505                 510         


Glu Met Thr Lys Ser Ser Pro Leu Lys Ile Thr Leu Phe Leu Glu Glu 
        515                 520                 525             


Asp Lys Ser Leu Lys Val Thr Ser Asp Pro Lys Val Glu Gln Lys Ile 
    530                 535                 540                 


Glu Val Ile Arg Glu Ile Glu Met Ser Val Asp Asp Asp Asp Ile Asn 
545                 550                 555                 560 


Ser Ser Lys Val Ile Asn Asp Leu Phe Ser Asp Val Leu Glu Glu Gly 
                565                 570                 575     


Glu Leu Asp Met Glu Lys Ser Gln Glu Glu Met Asp Gln Ala Leu Ala 
            580                 585                 590         


Glu Ser Ser Glu Glu Gln Glu Asp Ala Leu Asn Ile Ser Ser Met Ser 
        595                 600                 605             


Leu Leu Ala Pro Leu Ala Gln Thr Val Gly Val Val Ser Pro Glu Ser 
    610                 615                 620                 


Leu Val Ser Thr Pro Arg Leu Glu Leu Lys Asp Thr Ser Arg Ser Asp 
625                 630                 635                 640 


Glu Ser Pro Lys Pro Gly Lys Phe Gln Arg Thr Arg Val Pro Arg Ala 
                645                 650                 655     


Glu Ser Gly Asp Ser Leu Gly Ser Glu Asp Arg Asp Leu Leu Tyr Ser 
            660                 665                 670         


Ile Asp Ala Tyr Arg Ser Gln Arg Phe Lys Glu Thr Glu Arg Pro Ser 
        675                 680                 685             


Ile Lys Gln Val Ile Val Arg Lys Glu Asp Val Thr Ser Lys Leu Asp 
    690                 695                 700                 


Glu Lys Asn Asn Ala Phe Pro Cys Gln Val Asn Ile Lys Gln Lys Met 
705                 710                 715                 720 


Gln Glu Leu Asn Asn Glu Ile Asn Met Gln Gln Thr Val Ile Tyr Gln 
                725                 730                 735     


Ala Ser Gln Ala Leu Asn Cys Cys Val Asp Glu Glu His Gly Lys Gly 
            740                 745                 750         


Ser Leu Glu Glu Ala Glu Ala Glu Arg Leu Leu Leu Ile Ala Thr Gly 
        755                 760                 765             


Lys Arg Thr Leu Leu Ile Asp Glu Leu Asn Lys Leu Lys Asn Glu Gly 
    770                 775                 780                 


Pro Gln Arg Lys Asn Lys Ala Ser Pro Gln Ser Glu Phe Met Pro Ser 
785                 790                 795                 800 


Lys Gly Ser Val Thr Leu Ser Glu Ile Arg Leu Pro Leu Lys Ala Asp 
                805                 810                 815     


Phe Val Cys Ser Thr Val Gln Lys Pro Asp Ala Ala Asn Tyr Tyr Tyr 
            820                 825                 830         


Leu Ile Ile Leu Lys Ala Gly Ala Glu Asn Met Val Ala Thr Pro Leu 
        835                 840                 845             


Ala Ser Thr Ser Asn Ser Leu Asn Gly Asp Ala Leu Thr Phe Thr Thr 
    850                 855                 860                 


Thr Phe Thr Leu Gln Asp Val Ser Asn Asp Phe Glu Ile Asn Ile Glu 
865                 870                 875                 880 


Val Tyr Ser Leu Val Gln Lys Lys Asp Pro Ser Gly Leu Asp Lys Lys 
                885                 890                 895     


Lys Lys Thr Ser Lys Ser Lys Ala Ile Thr Pro Lys Arg Leu Leu Thr 
            900                 905                 910         


Ser Ile Thr Thr Lys Ser Asn Ile His Ser Ser Val Met Ala Ser Pro 
        915                 920                 925             


Gly Gly Leu Ser Ala Val Arg Thr Ser Asn Phe Ala Leu Val Gly Ser 
    930                 935                 940                 


Tyr Thr Leu Ser Leu Ser Ser Val Gly Asn Thr Lys Phe Val Leu Asp 
945                 950                 955                 960 


Lys Val Pro Phe Leu Ser Ser Leu Glu Gly His Ile Tyr Leu Lys Ile 
                965                 970                 975     


Lys Cys Gln Val Asn Ser Ser Val Glu Glu Arg Gly Phe Leu Thr Ile 
            980                 985                 990         


Phe Glu Asp Val Ser Gly Phe Gly  Ala Trp His Arg Arg  Trp Cys Val 
        995                 1000                 1005             


Leu Ser  Gly Asn Cys Ile Ser  Tyr Trp Thr Tyr Pro  Asp Asp Glu 
    1010                 1015                 1020             


Lys Arg  Lys Asn Pro Ile Gly  Arg Ile Asn Leu Ala  Asn Cys Thr 
    1025                 1030                 1035             


Ser Arg  Gln Ile Glu Pro Ala  Asn Arg Glu Phe Cys  Ala Arg Arg 
    1040                 1045                 1050             


Asn Thr  Phe Glu Leu Ile Thr  Val Arg Pro Gln Arg  Glu Asp Asp 
    1055                 1060                 1065             


Arg Glu  Thr Leu Val Ser Gln  Cys Arg Asp Thr Leu  Cys Val Thr 
    1070                 1075                 1080             


Lys Asn  Trp Leu Ser Ala Asp  Thr Lys Glu Glu Arg  Asp Leu Trp 
    1085                 1090                 1095             


Met Gln  Lys Leu Asn Gln Val  Leu Val Asp Ile Arg  Leu Trp Gln 
    1100                 1105                 1110             


Pro Asp  Ala Cys Tyr Lys Pro  Ile Gly Lys Pro 
    1115                 1120                 


