                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Zhang, Jingwei
       Keasling, Jay D
 
<120>  A Host Cell Modified to Produce Lactams

<130>  2016-119-02

<140>  PCT/US17/036168
<141>  2017-06-06

<150>  US 62/346294
<151>  2016-06-06

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  470
<212>  PRT
<213>  Streptomyces aizunensis

<400>  1

Met Arg Pro Met Thr Ala Lys Ile Phe Ala Val Asp Ser Val Arg Pro 
1               5                   10                  15      


Ile Asp Glu Phe Glu Gln Asp Ala Leu Arg Val Ala Asp Val Ile Arg 
            20                  25                  30          


Glu Arg Gly Val Cys Leu Gly Asp Arg Val Met Leu Lys Ala Gly Asn 
        35                  40                  45              


Ser Ala Ser Tyr Val Cys Val Leu Tyr Ala Leu Met His Ile Gly Ala 
    50                  55                  60                  


Ser Ile Val Leu Val Asp Gln Gln Glu His Lys Glu Glu Thr Arg Arg 
65                  70                  75                  80  


Ile Ala Leu Arg Thr Gly Val Lys Val Thr Phe Val Asp Asp Glu Thr 
                85                  90                  95      


Pro Ile Asp Gln Asp Ala Asp Pro Ile His Leu Tyr Glu Leu Met Val 
            100                 105                 110         


Ala Thr Gln Asn Arg Pro Pro Met Asp Ser Ala Leu Ser Phe Asp Ala 
        115                 120                 125             


Trp Gly Glu Leu Ser Asp Gly Leu Ile Met Trp Thr Ser Gly Ser Thr 
    130                 135                 140                 


Gly Ser Pro Lys Gly Val Val Lys Ser Gly Gly Lys Phe Leu Ala Asn 
145                 150                 155                 160 


Leu Arg Arg Asn Ala His Gln Val Gly His Arg Pro Asp Asp Val Leu 
                165                 170                 175     


Met Pro Leu Leu Pro Phe Ala His Gln Tyr Gly Leu Ser Met Val Leu 
            180                 185                 190         


Ile Ala Trp Leu Thr Arg Cys Ser Leu Val Ile Ala Pro Tyr Arg Arg 
        195                 200                 205             


Leu Asp Arg Ala Leu Arg Met Ala Arg Asp Ser Gly Thr Thr Val Ile 
    210                 215                 220                 


Asp Ala Thr Pro Ser Ser Tyr Arg Ser Ile Leu Gly Leu Val Thr Arg 
225                 230                 235                 240 


Lys Pro Ala Leu Arg Ala His Leu Ala Gly Thr Arg Met Phe Cys Val 
                245                 250                 255     


Gly Ala Ala Pro Leu Asp Ala Pro Leu Val Glu Ser Tyr Val Gln Glu 
            260                 265                 270         


Phe Gly Leu Pro Leu Leu Asp Ser Tyr Gly Ser Thr Glu Leu Asn Asn 
        275                 280                 285             


Ile Ala Phe Ala Thr Leu Asp Asn Pro Val Ser Cys Gly Arg Ala Met 
    290                 295                 300                 


Glu Gly Ile Gly Leu Arg Ile Val Asp Glu Asp Gly Arg Glu Val Ala 
305                 310                 315                 320 


Ala Gly Gln Pro Gly Glu Ile Glu Val Asp Thr Pro Asp Ala Leu Glu 
                325                 330                 335     


Gly Gln Ile Ala Glu Asp Gly Ser Ile Ile Pro Ala Pro Thr Gly Trp 
            340                 345                 350         


Gln Arg Thr Gly Asp Leu Gly His Leu Asp Ala Asp Gly Asn Leu Tyr 
        355                 360                 365             


Val Leu Gly Arg Lys Phe Ala Val His Arg Met Gly Tyr Thr Leu Tyr 
    370                 375                 380                 


Pro Glu Leu Ile Glu Arg Lys Val Ala Ala Glu Gly Cys Pro Thr Arg 
385                 390                 395                 400 


Ile Val Pro Leu Pro Asp Glu Leu Arg Gly Ser Gln Leu Val Phe Phe 
                405                 410                 415     


Val Glu Asp Asp Glu Gln Arg Asp Ala Gly Tyr Trp Arg Glu Arg Leu 
            420                 425                 430         


Cys Gly Leu Leu Pro Ala Phe Glu Gln Pro Asn Lys Val Val Val Leu 
        435                 440                 445             


Glu Gln Phe Pro Leu Asn Arg Asn Gly Lys Pro Asp Lys Lys Glu Leu 
    450                 455                 460                 


Thr Arg Met Ala Ala Glu 
465                 470 


<210>  2
<211>  366
<212>  PRT
<213>  Pyrococcus furiosus

<400>  2

Val Val Ile Trp His Ala Met Gln Pro Asn Glu Leu Glu Val Phe Gln 
1               5                   10                  15      


Ser Leu Ala Glu Glu Tyr Met Ala Leu Cys Pro Glu Val Glu Ile Val 
            20                  25                  30          


Phe Glu Gln Lys Pro Asn Leu Glu Asp Ala Leu Lys Ala Ala Ile Pro 
        35                  40                  45              


Thr Gly Gln Gly Pro Asp Leu Phe Ile Trp Ala His Asp Trp Ile Gly 
    50                  55                  60                  


Lys Phe Ala Glu Ala Gly Leu Leu Glu Pro Ile Asp Glu Tyr Val Thr 
65                  70                  75                  80  


Glu Asp Leu Leu Asn Glu Phe Ala Pro Met Ala Gln Asp Ala Met Gln 
                85                  90                  95      


Tyr Lys Gly His Tyr Tyr Ala Leu Pro Phe Ala Ala Glu Thr Val Ala 
            100                 105                 110         


Ile Ile Tyr Asn Lys Glu Met Val Ser Glu Pro Pro Lys Thr Phe Asp 
        115                 120                 125             


Glu Met Lys Ala Ile Met Glu Lys Tyr Tyr Asp Pro Ala Asn Glu Lys 
    130                 135                 140                 


Tyr Gly Ile Ala Trp Pro Ile Asn Ala Tyr Phe Ile Ser Ala Ile Ala 
145                 150                 155                 160 


Gln Ala Phe Gly Gly Tyr Tyr Phe Asp Asp Lys Thr Glu Gln Pro Gly 
                165                 170                 175     


Leu Asp Lys Pro Glu Thr Ile Glu Gly Phe Lys Phe Phe Phe Thr Glu 
            180                 185                 190         


Ile Trp Pro Tyr Met Ala Pro Thr Gly Asp Tyr Asn Thr Gln Gln Ser 
        195                 200                 205             


Ile Phe Leu Glu Gly Arg Ala Pro Met Met Val Asn Gly Pro Trp Ser 
    210                 215                 220                 


Ile Asn Asp Val Lys Lys Ala Gly Ile Asn Phe Gly Val Val Pro Leu 
225                 230                 235                 240 


Pro Pro Ile Ile Lys Asp Gly Lys Glu Tyr Trp Pro Arg Pro Tyr Gly 
                245                 250                 255     


Gly Val Lys Leu Ile Tyr Phe Ala Ala Gly Ile Lys Asn Lys Asp Ala 
            260                 265                 270         


Ala Trp Lys Phe Ala Lys Trp Leu Thr Thr Ser Glu Glu Ser Ile Lys 
        275                 280                 285             


Thr Leu Ala Leu Glu Leu Gly Tyr Ile Pro Val Leu Thr Lys Val Leu 
    290                 295                 300                 


Asp Asp Pro Glu Ile Lys Asn Asp Pro Val Ile Tyr Gly Phe Gly Gln 
305                 310                 315                 320 


Ala Val Gln His Ala Tyr Leu Met Pro Lys Ser Pro Lys Met Ser Ala 
                325                 330                 335     


Val Trp Gly Gly Val Asp Gly Ala Ile Asn Glu Ile Leu Gln Asp Pro 
            340                 345                 350         


Gln Asn Ala Asp Ile Glu Gly Ile Leu Lys Lys Tyr Gln Gln 
        355                 360                 365     


<210>  3
<211>  355
<212>  PRT
<213>  Pyrobaculum aerophilum

<400>  3

Ile Arg Ile Trp His Ala Leu Asn Pro Glu Glu Glu Ser Val Phe Lys 
1               5                   10                  15      


Gln Ile Ala Ala Met Tyr Thr Gln Thr His Pro Asn Val Gln Ile Val 
            20                  25                  30          


Phe Glu Asn Lys Ala Pro Asp Leu Gln Thr Ala Val Leu Ala Ala Ile 
        35                  40                  45              


Ser Thr Gly Glu Lys Phe Asp Leu Phe Ile Trp Ala His Asp Trp Ile 
    50                  55                  60                  


Gly Leu Met Val Glu Ala Gly Val Leu Lys Pro Val Asp Asn Glu Val 
65                  70                  75                  80  


Ala Asp Val Leu Ser Arg Phe Ser Ala Pro Ile Pro Gln Tyr Lys Gly 
                85                  90                  95      


His Ile Tyr Gly Leu Pro Phe Ala Ala Glu Thr Val Ala Leu Ile Cys 
            100                 105                 110         


Asn Lys Gln Met Val Ser Gln Pro Pro Lys Thr Phe Ala Asp Leu Leu 
        115                 120                 125             


Ala Ile Met Arg Gln Phe Asn Lys Pro Pro Gln Thr Tyr Gly Ile Ala 
    130                 135                 140                 


Tyr Val Val Asn Pro Tyr Phe Ile Ser Ala Trp Ile His Gly Ala Gly 
145                 150                 155                 160 


Gly Tyr Tyr Phe Asp Asp Glu Thr Glu Lys Gln Gly Leu Thr Asp Pro 
                165                 170                 175     


Lys Ser Ile Ala Gly Phe Thr Phe Phe Lys Ser Tyr Ile Met Pro Tyr 
            180                 185                 190         


Val Gly Pro Asn Pro Thr Asp Tyr Asn Thr Gln Val Asn Leu Phe Leu 
        195                 200                 205             


Ser Gly Gln Ala Pro Cys Met Val Asn Gly Pro Trp Ser Ile Gly Ala 
    210                 215                 220                 


Val Lys Gln Arg Gly Ile Asp Val Phe Val Ala Pro Leu Pro Pro Val 
225                 230                 235                 240 


Asn Ala Thr Tyr Ile Pro Lys Pro Tyr Gly Gly Met Lys Met Phe Tyr 
                245                 250                 255     


Val Thr Ile Tyr Ala Ser Lys Glu Ala Ile Asp Phe Met Lys Trp Phe 
            260                 265                 270         


Thr Thr Asp Pro Gln Val Ala Lys Ile Leu Met Asp Gln Leu Gly Tyr 
        275                 280                 285             


Val Pro Val Ile Lys Asp Val Gln Ile Gln Asp Pro Val Val Gln Gly 
    290                 295                 300                 


Phe Tyr Glu Ala Val Lys Asn Ile Tyr Leu Met Pro Val Ser Pro Lys 
305                 310                 315                 320 


Met Gln Pro Val Trp Gly Thr Val Asp Leu Ile Ile Gln Asn Ser Ile 
                325                 330                 335     


Val Ser Asp Gln Lys Thr Ile Ser Leu Ala Val Asn Asp Ala Val Lys 
            340                 345                 350         


Asp Leu Leu 
        355 


<210>  4
<211>  360
<212>  PRT
<213>  Escherichia coli

<400>  4

Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly Leu Ala Glu 
1               5                   10                  15      


Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val Thr Val Glu 
            20                  25                  30          


His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala Ala Thr Gly 
        35                  40                  45              


Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe Gly Gly Tyr 
    50                  55                  60                  


Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys Ala Phe Gln 
65                  70                  75                  80  


Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr Asn Gly Lys 
                85                  90                  95      


Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu Ile Tyr Asn 
            100                 105                 110         


Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu Ile Pro Ala 
        115                 120                 125             


Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu Met Phe Asn 
    130                 135                 140                 


Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala Asp Gly Gly 
145                 150                 155                 160 


Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys Asp Val Gly 
                165                 170                 175     


Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu Val Asp Leu 
            180                 185                 190         


Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser Ile Ala Glu 
        195                 200                 205             


Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn Gly Pro Trp 
    210                 215                 220                 


Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly Val Thr Val 
225                 230                 235                 240 


Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val Gly Val Leu 
                245                 250                 255     


Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu Ala Lys Glu 
            260                 265                 270         


Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu Ala Val Asn 
        275                 280                 285             


Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr Glu Glu Glu 
    290                 295                 300                 


Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn Ala Gln Lys 
305                 310                 315                 320 


Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe Trp Tyr Ala 
                325                 330                 335     


Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln Thr Val Asp 
            340                 345                 350         


Glu Ala Leu Lys Asp Ala Gln Thr 
        355                 360 


<210>  5
<211>  343
<212>  PRT
<213>  Methanococcus aeolicus

<400>  5

Met Lys Ile Pro Lys Ile Cys Val Ile Glu Gly Asp Gly Ile Gly Lys 
1               5                   10                  15      


Glu Val Ile Pro Glu Thr Val Arg Ile Leu Lys Glu Ile Gly Asp Phe 
            20                  25                  30          


Glu Phe Ile Tyr Glu His Ala Gly Tyr Glu Cys Phe Lys Arg Cys Gly 
        35                  40                  45              


Asp Ala Ile Pro Glu Lys Thr Leu Lys Thr Ala Lys Glu Cys Asp Ala 
    50                  55                  60                  


Ile Leu Phe Gly Ala Val Ser Thr Pro Lys Leu Asp Glu Thr Glu Arg 
65                  70                  75                  80  


Lys Pro Tyr Lys Ser Pro Ile Leu Thr Leu Arg Lys Glu Leu Asp Leu 
                85                  90                  95      


Tyr Ala Asn Val Arg Pro Ile His Lys Leu Asp Asn Ser Asp Ser Ser 
            100                 105                 110         


Asn Asn Ile Asp Phe Ile Ile Ile Arg Glu Asn Thr Glu Gly Leu Tyr 
        115                 120                 125             


Ser Gly Val Glu Tyr Tyr Asp Glu Glu Lys Glu Leu Ala Ile Ser Glu 
    130                 135                 140                 


Arg His Ile Ser Lys Lys Gly Ser Lys Arg Ile Ile Lys Phe Ala Phe 
145                 150                 155                 160 


Glu Tyr Ala Val Lys His His Arg Lys Lys Val Ser Cys Ile His Lys 
                165                 170                 175     


Ser Asn Ile Leu Arg Ile Thr Asp Gly Leu Phe Leu Asn Ile Phe Asn 
            180                 185                 190         


Glu Phe Lys Glu Lys Tyr Lys Asn Glu Tyr Asn Ile Glu Gly Asn Asp 
        195                 200                 205             


Tyr Leu Val Asp Ala Thr Ala Met Tyr Ile Leu Lys Ser Pro Gln Met 
    210                 215                 220                 


Phe Asp Val Ile Val Thr Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp 
225                 230                 235                 240 


Glu Ala Ser Gly Leu Leu Gly Gly Leu Gly Leu Ala Pro Ser Ala Asn 
                245                 250                 255     


Ile Gly Asp Asn Tyr Gly Leu Phe Glu Pro Val His Gly Ser Ala Pro 
            260                 265                 270         


Asp Ile Ala Gly Lys Gly Val Ala Asn Pro Ile Ala Ala Val Leu Ser 
        275                 280                 285             


Ala Ser Met Met Leu Tyr Tyr Leu Asp Met Lys Glu Lys Ser Arg Leu 
    290                 295                 300                 


Leu Lys Asp Ala Val Lys Gln Val Leu Ala His Lys Asp Ile Thr Pro 
305                 310                 315                 320 


Asp Leu Gly Gly Asn Leu Lys Thr Lys Glu Val Ser Asp Lys Ile Ile 
                325                 330                 335     


Glu Glu Leu Arg Lys Ile Ser 
            340             


<210>  6
<211>  898
<212>  DNA
<213>  Pseudomonas putida

<400>  6
cccgatcgcc ctggcggatt gaggatcttt taagaaggag atatacatat gcgcatcgct       60

ctgtaccagg gcgcacccaa gccactggat gtgcccggca acctgcaacg gctgcgccac      120

caggcgcagt tggcagccga ccgcggcgca cagttgctgg tgtgcccgga gatgttcctg      180

tccggctaca acatcggcct ggcccaggtc gagcgcctgg ccgaggccgc cgatggcccg      240

gcagccatga cggtggtgga gattgcccag gcgcaccgta tcgccattgt ctatggctac      300

ccggagcgcg gcgatgacgg ggcgatctac aacagcgtgc agctgatcga tgcgcatggc      360

cgcagcctga gcaattaccg caagacccac ctgttcggtg aactggaccg ctcgatgttc      420

agccctggtg cggaccactt cccggtggtg gaactggaag gctggaaggt tggcctgctg      480

atctgctacg acatcgagtt cccggagaac gcccgacgcc tggcgctgga cggcgccgag      540

ctgatcctgg tgccgacggc gaacatgacg ccgtacgact ttacctgcca ggtgaccgtg      600

agggcacggg cgcaggaaaa ccagtgctac ctggtatatg ccaactactg cggcgcggaa      660

gacgagatcg agtattgcgg gcagagcagc atcatcggcc cggatggcag cttgctggcc      720

atggccgggc gggatgagtg ccagttgttg gcagagctcg agcatgagcg ggtggtgcag      780

gggcgcaggg cgtttcccta cctgaccgat ttgcgccagg agctgcacct gcgtaaaggc      840

tgaggatcca aactcgagta aggatctcca ggcatcaaat aaaacgaaag gctcagtc        898


<210>  7
<211>  6146
<212>  DNA
<213>  Pseudomonas putida

<400>  7
gacgtcctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat       60

cggccaacgc gcggggagag gcggtttgcg tattgggcgc cagggtggtt tttcttttca      120

ccagtgagac gggcaacagc tgattgccct tcaccgcctg gccctgagag agttgcagca      180

agcggtccac gctggtttgc cccagcaggc gaaaatcctg tttgatggtg gttaacggcg      240

ggatataaca tgagctgtct tcggtatcgt cgtatcccac taccgagatg tccgcaccaa      300

cgcgcagccc ggactcggta atggcgcgca ttgcgcccag cgccatctga tcgttggcaa      360

ccagcatcgc agtgggaacg atgccctcat tcagcatttg catggtttgt tgaaaaccgg      420

acatggcact ccagtcgcct tcccgttccg ctatcggctg aatttgattg cgagtgagat      480

atttatgcca gccagccaga cgcagacgcg ccgagacaga acttaatggg cccgctaaca      540

gcgcgatttg ctggtgaccc aatgcgacca gatgctccac gcccagtcgc gtaccgtctt      600

catgggagaa aataatactg ttgatgggtg tctggtcaga gacatcaaga aataacgccg      660

gaacattagt gcaggcagct tccacagcaa tggcatcctg gtcatccagc ggatagttaa      720

tgatcagccc actgacgcgt tgcgcgagaa gattgtgcac cgccgcttta caggcttcga      780

cgccgcttcg ttctaccatc gacaccacca cgctggcacc cagttgatcg gcgcgagatt      840

taatcgccgc gacaatttgc gacggcgcgt gcagggccag actggaggtg gcaacgccaa      900

tcagcaacga ctgtttgccc gccagttgtt gtgccacgcg gttgggaatg taattcagct      960

ccgccatcgc cgcttccact ttttcccgcg ttttcgcaga aacgtggctg gcctggttca     1020

ccacgcggga aacggtctga taagagacac cggcatactc tgcgacatcg tataacgtta     1080

ctggtttcac attcaccacc ctgaattgac tctcttccgg gcgctatcat gccataccgc     1140

gaaaggtttt gcgccattcg atggtgtccg ggatctcgac gctctccctt atgcgactcc     1200

tgcattagga agcagcccag tagtaggttg aggccgttga gcaccgccgc cgcaaggaat     1260

ggtgcatgca aggagatggc gcccaacagt cccccggcca cggggcctgc caccataccc     1320

acgccgaaac aagcgctcat gagcccgaag tggcgagccc gatcttcccc atcggtgatg     1380

tcggcgatat aggcgccagc aaccgcacct gtggcgccgg tgatgccggc cacgatgcgt     1440

ccggcgtaga ggatcgagat cgatctcgat cccgcgaaat taatacgact cactataggg     1500

gaattgtgag cggataacaa tttcagaatt caaaagatct tttaagaagg agatatacat     1560

atgaacaaga agaaccgcca ccccgccgac ggcaagaagc cgatcaccat tttcggcccg     1620

gacttccctt ttgctttcga cgactggctg gaacacccgg caggcctggg cagcattccg     1680

gctgagcgcc atggggaaga ggtggccatt gtcggtgccg gtatcgccgg cctggtagcg     1740

gcctacgagc tgatgaagct gggcctcaag ccggtggtgt acgaggcttc caagctgggc     1800

ggccggctgc gctcgcaagc cttcaatggc actgacggga tcgttgccga gctgggtggc     1860

atgcgcttcc cggtgtcgtc caccgccttc taccactacg tcgacaagct gggcctggag     1920

accaagccct tccccaaccc gctgaccccg gcttcgggca gcacggtgat cgacctggaa     1980

ggccagacct actacgccga gaagcccacc gacctgccgc aactgtttca tgaggtagcc     2040

gacgcttggg ccgatgctct ggagagcggt gcgcagttcg ccgatatcca gcaggccatc     2100

cgcgaccgtg atgtaccgcg cctgaaggaa ctctggaaca agctggtgcc actgtgggac     2160

gaccgcacct tctacgactt cgtcgccacc tcgcgctctt ttgccaagct gagcttccag     2220

caccgcgaag tgttcggcca ggtcggtttc ggcaccggcg gttgggactc ggacttcccc     2280

aactcgatgc tggaaatctt ccgcgtggtg atgaccaact gcgacgacca ccagcacctg     2340

gtggtcgggg gcgtggaaca agtgccacaa ggcatctggc gcgacgtacc ggaacgctgc     2400

gtgcattggc cagagggcac cagcctgagc acgctgcatg gcggcgcacc gcgtaccggg     2460

gtcaagcgca ttgcccgcgc cgccgatggc cgcctggcgg tcaccgacaa ctggggcgat     2520

acccgccact acagcgcagt actcgccacc tgccagacct ggttgctgac cacccagatc     2580

gactgcgagg aatcgctgtt ctcgcaaaag atgtggatgg ccctggaccg tacccgctac     2640

atgcagtcgt cgaaaacctt cgtcatggtc gaccgcccgt tctggaagga caaggacccg     2700

gaaaccggcc gtgacctgct gagcatgacc ctcaccgacc gcctcacccg cggcacttac     2760

ctgttcgaca acggcaacga caagcccggg gtgatctgcc tgtcgtactc gtggatgagc     2820

gacgcgctga agatgctgcc gcacccggtg gaaaagcgcg tacaactggc cctggatgcg     2880

ctgaagaaga tctacccgaa gaccgatatc gccgggcaca tcatcggcga cccgatcacg     2940

gtttcctggg aggccgaccc gtacttcctc ggcgccttca aaggcgcgct tccgggccat     3000

taccgctaca accagcgcat gtacgcgcac ttcatgcagc aggacatgcc ggcggagcag     3060

cgcggtatct tcattgccgg tgacgacgtg tcatggaccc ccgcctgggt tgaaggcgcg     3120

gtgcagacgt cgctgaatgc ggtgtggggt atcatgaacc actttggtgg ccacacccac     3180

cccgacaacc ccggcccggg cgatgtgttc aacgaaatcg gcccgatcgc cctggcggat     3240

tgaggatctt ttaagaagga gatatacata tgcgcatcgc tctgtaccag ggcgcaccca     3300

agccactgga tgtgcccggc aacctgcaac ggctgcgcca ccaggcgcag ttggcagccg     3360

accgcggcgc acagttgctg gtgtgcccgg agatgttcct gtccggctac aacatcggcc     3420

tggcccaggt cgagcgcctg gccgaggccg ccgatggccc ggcagccatg acggtggtgg     3480

agattgccca ggcgcaccgt atcgccattg tctatggcta cccggagcgc ggcgatgacg     3540

gggcgatcta caacagcgtg cagctgatcg atgcgcatgg ccgcagcctg agcaattacc     3600

gcaagaccca cctgttcggt gaactggacc gctcgatgtt cagccctggt gcggaccact     3660

tcccggtggt ggaactggaa ggctggaagg ttggcctgct gatctgctac gacatcgagt     3720

tcccggagaa cgcccgacgc ctggcgctgg acggcgccga gctgatcctg gtgccgacgg     3780

cgaacatgac gccgtacgac tttacctgcc aggtgaccgt gagggcacgg gcgcaggaaa     3840

accagtgcta cctggtatat gccaactact gcggcgcgga agacgagatc gagtattgcg     3900

ggcagagcag catcatcggc ccggatggca gcttgctggc catggccggg cgggatgagt     3960

gccagttgtt ggcagagctc gagcatgagc gggtggtgca ggggcgcagg gcgtttccct     4020

acctgaccga tttgcgccag gagctgcacc tgcgtaaagg ctgaggatcc aaactcgagt     4080

aaggatctcc aggcatcaaa taaaacgaaa ggctcagtcg aaagactggg cctttcgttt     4140

tatctgttgt ttgtcggtga acgctctcta ctagagtcac actggctcac cttcgggtgg     4200

gcctttctgc gtttatacct agggatatat tccgcttcct cgctcactga ctcgctacgc     4260

tcggtcgttc gactgcggcg agcggaaatg gcttacgaac ggggcggaga tttcctggaa     4320

gatgccagga agatacttaa cagggaagtg agagggccgc ggcaaagccg tttttccata     4380

ggctccgccc ccctgacaag catcacgaaa tctgacgctc aaatcagtgg tggcgaaacc     4440

cgacaggact ataaagatac caggcgtttc cccctggcgg ctccctcgtg cgctctcctg     4500

ttcctgcctt tcggtttacc ggtgtcattc cgctgttatg gccgcgtttg tctcattcca     4560

cgcctgacac tcagttccgg gtaggcagtt cgctccaagc tggactgtat gcacgaaccc     4620

cccgttcagt ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggaa     4680

agacatgcaa aagcaccact ggcagcagcc actggtaatt gatttagagg agttagtctt     4740

gaagtcatgc gccggttaag gctaaactga aaggacaagt tttggtgact gcgctcctcc     4800

aagccagtta cctcggttca aagagttggt agctcagaga accttcgaaa aaccgccctg     4860

caaggcggtt ttttcgtttt cagagcaaga gattacgcgc agaccaaaac gatctcaaga     4920

agatcatctt attaatcaga taaaatattt ctagatttca gtgcaattta tctcttcaaa     4980

tgtagcacct gaagtcagcc ccatacgata taagttgtta ctagtgcttg gattctcacc     5040

aataaaaaac gcccggcggc aaccgagcgt tctgaacaaa tccagatgga gttctgaggt     5100

cattactgga tctatcaaca ggagtccaag cgagctcgta aacttggtct gacagttacc     5160

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     5220

cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg     5280

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     5340

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta     5400

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     5460

ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct     5520

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     5580

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     5640

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     5700

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     5760

gcccggcgtc aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca     5820

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     5880

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     5940

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     6000

aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt     6060

gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc     6120

gcacatttcc ccgaaaagtg ccacct                                          6146


<210>  8
<211>  7856
<212>  DNA
<213>  Streptomyces aizunensis

<400>  8
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca gccatcatca tcatcatcac     5100

agcagcggca aaatcgaaga aggtaaactg gtaatctgga ttaacggcga taaaggctat     5160

aacggtctcg ctgaagtcgg taagaaattc gagaaagata ccggaattaa agtcaccgtt     5220

gagcatccgg ataaactgga agagaaattc ccacaggttg cggcaactgg cgatggccct     5280

gacattatct tctgggcaca cgaccgcttt ggtggctacg ctcaatctgg cctgttggct     5340

gaaatcaccc cggacaaagc gttccaggac aagctgtatc cgtttacctg ggatgccgta     5400

cgttacaacg gcaagctgat tgcttacccg atcgctgttg aagcgttatc gctgatttat     5460

aacaaagatc tgctgccgaa cccgccaaaa acctgggaag agatcccggc gctggataaa     5520

gaactgaaag cgaaaggtaa gagcgcgctg atgttcaacc tgcaagaacc gtacttcacc     5580

tggccgctga ttgctgctga cgggggttat gcgttcaagt atgaaaacgg caagtacgac     5640

attaaagacg tgggcgtgga taacgctggc gcgaaagcgg gtctgacctt cctggttgac     5700

ctgattaaaa acaaacacat gaatgcagac accgattact ccatcgcaga agctgccttt     5760

aataaaggcg aaacagcgat gaccatcaac ggcccgtggg catggtccaa catcgacacc     5820

agcaaagtga attatggtgt aacggtactg ccgaccttca agggtcaacc atccaaaccg     5880

ttcgttggcg tgctgagcgc aggtattaac gccgccagtc cgaacaaaga gctggcaaaa     5940

gagttcctcg aaaactatct gctgactgat gaaggtctgg aagcggttaa taaagacaaa     6000

ccgctgggtg ccgtagcgct gaagtcttac gaggaagagt tggcgaaaga tccacgtatt     6060

gccgccacta tggaaaacgc ccagaaaggt gaaatcatgc cgaacatccc gcagatgtcc     6120

gctttctggt atgccgtgcg tactgcggtg atcaacgccg ccagcggtcg tcagactgtc     6180

gatgaagccc tgaaagacgc gcagactagc agcggcctgg tgccgcgcgg cagccatatg     6240

cgcccaatga ccgctaaaat cttcgccgtc gactccgtcc gtccgatcga cgagtttgag     6300

caggacgcac tgcgcgttgc ggatgtgatt cgcgaacgtg gcgtgtgtct gggtgaccgt     6360

gtgatgttga aggcgggcaa cagcgcgtcg tacgtttgcg ttttgtatgc gctgatgcac     6420

atcggtgcga gcatcgtttt ggtcgatcag caagagcata aagaggaaac ccgtcgtatc     6480

gcgctgcgta ccggcgtaaa agtcacgttt gtggatgatg aaaccccgat tgatcaagat     6540

gcggacccga ttcacctgta cgagctgatg gtggctaccc agaaccgtcc tccgatggac     6600

agcgcactga gcttcgacgc gtggggtgaa ctgtctgacg gtctgattat gtggacgagc     6660

ggcagcaccg gtagcccgaa gggtgtcgtg aagagcggtg gtaaattcct ggcgaatctg     6720

cgccgtaacg cgcatcaagt gggtcatcgt ccggatgacg tgctgatgcc gctgctgccg     6780

ttcgcgcacc agtacggtct gtctatggtg ctgattgcat ggctgacgcg ctgctccctg     6840

gttattgcgc cataccgccg tctggatcgt gctttgcgta tggcccgtga cagcggcacg     6900

accgttatcg atgccacgcc gagcagctat cgcagcatcc tgggcctggt cacgcgtaaa     6960

ccggccctgc gtgcacacct ggccggcacc cgcatgttct gtgtgggcgc agcgccgttg     7020

gatgcgccgc tggtcgaaag ctacgttcaa gagtttggtc tgccgctgtt ggacagctat     7080

ggttctaccg agctgaacaa tatcgctttc gcgaccctgg ataatccggt ttcctgtggt     7140

cgcgcaatgg aaggtatcgg tctgcgtatt gttgacgaag atggtcgtga agttgcggca     7200

ggccaaccgg gcgaaatcga ggttgacact ccggatgccc tggagggtca aatcgccgag     7260

gatggtagca ttattccggc accgaccggc tggcagcgta cgggcgatct gggtcacttg     7320

gacgccgacg gcaacctgta tgtcctgggt cgtaagtttg cggtccaccg catgggttat     7380

actttgtacc cagagctgat tgagcgcaaa gtggccgctg agggctgccc gacccgcatt     7440

gttccgctgc cggacgagct gcgtggtagc caactggtct ttttcgtgga agatgatgaa     7500

cagcgtgacg caggttactg gcgtgaacgt ctgtgcggtt tgctgccggc gttcgagcag     7560

ccgaacaagg tggtcgttct ggagcagttt cctctgaatc gcaatggcaa gccggacaag     7620

aaagagctga cccgtatggc ggcagaatga taaggatccg aattcgagct ccgtcgacaa     7680

gcttgcggcc gcactcgagc accaccacca ccaccactga gatccggctg ctaacaaagc     7740

ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg     7800

ggcctctaaa cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggat         7856


<210>  9
<211>  264
<212>  PRT
<213>  Pseudomonas putida

<400>  9

Met Arg Ile Ala Leu Tyr Gln Gly Ala Pro Lys Pro Leu Asp Val Pro 
1               5                   10                  15      


Gly Asn Leu Gln Arg Leu Arg His Gln Ala Gln Leu Ala Ala Glu Arg 
            20                  25                  30          


Gly Ala Gln Leu Leu Val Cys Pro Glu Met Phe Leu Thr Gly Tyr Asn 
        35                  40                  45              


Ile Gly Leu Ala Gln Val Glu Arg Leu Ala Glu Ala Ala Asp Gly Pro 
    50                  55                  60                  


Ala Ala Met Thr Val Val Glu Ile Ala Gln Ala His Arg Ile Ala Ile 
65                  70                  75                  80  


Val Tyr Gly Tyr Pro Glu Arg Gly Asp Asp Gly Ala Ile Tyr Asn Ser 
                85                  90                  95      


Val Gln Leu Ile Asp Ala His Gly Arg Ser Leu Ser Asn Tyr Arg Lys 
            100                 105                 110         


Thr His Leu Phe Gly Glu Leu Asp Arg Ser Met Phe Ser Pro Gly Ala 
        115                 120                 125             


Asp His Phe Pro Val Val Glu Leu Glu Gly Trp Lys Val Gly Leu Leu 
    130                 135                 140                 


Ile Cys Tyr Asp Ile Glu Phe Pro Glu Asn Ala Arg Arg Leu Ala Leu 
145                 150                 155                 160 


Asp Gly Ala Glu Leu Ile Leu Val Pro Thr Ala Asn Met Thr Pro Tyr 
                165                 170                 175     


Asp Phe Thr Cys Gln Val Thr Val Arg Ala Arg Ala Gln Glu Asn Gln 
            180                 185                 190         


Cys Tyr Leu Val Tyr Ala Asn Tyr Cys Gly Ala Glu Asp Glu Ile Glu 
        195                 200                 205             


Tyr Cys Gly Gln Ser Ser Ile Ile Gly Pro Asp Gly Ser Leu Leu Ala 
    210                 215                 220                 


Met Ala Gly Arg Asp Glu Cys Gln Leu Leu Ala Glu Leu Glu His Glu 
225                 230                 235                 240 


Arg Val Val Gln Gly Arg Thr Ala Phe Pro Tyr Leu Thr Asp Leu Arg 
                245                 250                 255     


Gln Glu Leu His Leu Arg Lys Gly 
            260                 


<210>  10
<211>  560
<212>  PRT
<213>  Pseudomonas putida

<400>  10

Met Asn Lys Lys Asn Arg His Pro Ala Asp Gly Lys Lys Pro Ile Thr 
1               5                   10                  15      


Ile Phe Gly Pro Asp Phe Pro Phe Ala Phe Asp Asp Trp Leu Glu His 
            20                  25                  30          


Pro Ala Gly Leu Gly Ser Ile Pro Ala Glu Arg His Gly Glu Glu Val 
        35                  40                  45              


Ala Ile Val Gly Ala Gly Ile Ala Gly Leu Val Ala Ala Tyr Glu Leu 
    50                  55                  60                  


Met Lys Leu Gly Leu Lys Pro Val Val Tyr Glu Ala Ser Lys Leu Gly 
65                  70                  75                  80  


Gly Arg Leu Arg Ser Gln Ala Phe Asn Gly Thr Asp Gly Ile Val Ala 
                85                  90                  95      


Glu Leu Gly Gly Met Arg Phe Pro Val Ser Ser Thr Ala Phe Tyr His 
            100                 105                 110         


Tyr Val Asp Lys Leu Gly Leu Glu Thr Lys Pro Phe Pro Asn Pro Leu 
        115                 120                 125             


Thr Pro Ala Ser Gly Ser Thr Val Ile Asp Leu Glu Gly Gln Thr Tyr 
    130                 135                 140                 


Tyr Ala Glu Lys Pro Thr Asp Leu Pro Gln Leu Phe His Glu Val Ala 
145                 150                 155                 160 


Asp Ala Trp Ala Asp Ala Leu Glu Ser Gly Ala Gln Phe Ala Asp Ile 
                165                 170                 175     


Gln Gln Ala Ile Arg Asp Arg Asp Val Pro Arg Leu Lys Glu Leu Trp 
            180                 185                 190         


Asn Lys Leu Val Pro Leu Trp Asp Asp Arg Thr Phe Tyr Asp Phe Val 
        195                 200                 205             


Ala Thr Ser Arg Ser Phe Ala Lys Leu Ser Phe Gln His Arg Glu Val 
    210                 215                 220                 


Phe Gly Gln Val Gly Phe Gly Thr Gly Gly Trp Asp Ser Asp Phe Pro 
225                 230                 235                 240 


Asn Ser Met Leu Glu Ile Phe Arg Val Val Met Thr Asn Cys Asp Asp 
                245                 250                 255     


His Gln His Leu Val Val Gly Gly Val Glu Gln Val Pro Gln Gly Ile 
            260                 265                 270         


Trp Arg His Val Pro Glu Arg Cys Val His Trp Pro Glu Gly Thr Ser 
        275                 280                 285             


Leu Ser Thr Leu His Gly Gly Ala Pro Arg Thr Gly Val Lys Arg Ile 
    290                 295                 300                 


Ala Arg Ala Ser Asp Gly Arg Leu Ala Val Thr Asp Asn Trp Gly Asp 
305                 310                 315                 320 


Thr Arg His Tyr Ser Ala Val Leu Ala Thr Cys Gln Thr Trp Leu Leu 
                325                 330                 335     


Thr Thr Gln Ile Asp Cys Glu Glu Ser Leu Phe Ser Gln Lys Met Trp 
            340                 345                 350         


Met Ala Leu Asp Arg Thr Arg Tyr Met Gln Ser Ser Lys Thr Phe Val 
        355                 360                 365             


Met Val Asp Arg Pro Phe Trp Lys Asp Lys Asp Pro Glu Thr Gly Arg 
    370                 375                 380                 


Asp Leu Leu Ser Met Thr Leu Thr Asp Arg Leu Thr Arg Gly Thr Tyr 
385                 390                 395                 400 


Leu Phe Asp Asn Gly Asn Asp Lys Pro Gly Val Ile Cys Leu Ser Tyr 
                405                 410                 415     


Ser Trp Met Ser Asp Ala Leu Lys Met Leu Pro His Pro Val Glu Lys 
            420                 425                 430         


Arg Val Gln Leu Ala Leu Asp Ala Leu Lys Lys Ile Tyr Pro Lys Thr 
        435                 440                 445             


Asp Ile Ala Gly His Ile Ile Gly Asp Pro Ile Thr Val Ser Trp Glu 
    450                 455                 460                 


Ala Asp Pro Tyr Phe Leu Gly Ala Phe Lys Gly Ala Leu Pro Gly His 
465                 470                 475                 480 


Tyr Arg Tyr Asn Gln Arg Met Tyr Ala His Phe Met Gln Gln Asp Met 
                485                 490                 495     


Pro Ala Glu Gln Arg Gly Ile Phe Ile Ala Gly Asp Asp Val Ser Trp 
            500                 505                 510         


Thr Pro Ala Trp Val Glu Gly Ala Val Gln Thr Ser Leu Asn Ala Val 
        515                 520                 525             


Trp Gly Ile Met Asn His Phe Gly Gly His Thr His Pro Asp Asn Pro 
    530                 535                 540                 


Gly Pro Gly Asp Val Phe Asn Glu Ile Gly Pro Ile Ala Leu Ala Asp 
545                 550                 555                 560 


<210>  11
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer designed to target C-6xHis-ORF27

<400>  11
gcgcgccatg ggcatgcgcc caatgaccgc taaaatcttc g                           41


<210>  12
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer designed to target C-6xHis-ORF27

<400>  12
gcgcgctcga gttctgccgc catacgggtc agc                                    33


<210>  13
<211>  859
<212>  PRT
<213>  Streptomyces aizunensis

<400>  13

Met Gly Ser Ser His His His His His His Ser Ser Gly Lys Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys Gly Tyr Asn Gly 
            20                  25                  30          


Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr Gly Ile Lys Val 
        35                  40                  45              


Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe Pro Gln Val Ala 
    50                  55                  60                  


Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala His Asp Arg Phe 
65                  70                  75                  80  


Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile Thr Pro Asp Lys 
                85                  90                  95      


Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp Ala Val Arg Tyr 
            100                 105                 110         


Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu Ala Leu Ser Leu 
        115                 120                 125             


Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys Thr Trp Glu Glu 
    130                 135                 140                 


Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly Lys Ser Ala Leu 
145                 150                 155                 160 


Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro Leu Ile Ala Ala 
                165                 170                 175     


Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys Tyr Asp Ile Lys 
            180                 185                 190         


Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly Leu Thr Phe Leu 
        195                 200                 205             


Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp Thr Asp Tyr Ser 
    210                 215                 220                 


Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala Met Thr Ile Asn 
225                 230                 235                 240 


Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys Val Asn Tyr Gly 
                245                 250                 255     


Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser Lys Pro Phe Val 
            260                 265                 270         


Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro Asn Lys Glu Leu 
        275                 280                 285             


Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp Glu Gly Leu Glu 
    290                 295                 300                 


Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala Leu Lys Ser Tyr 
305                 310                 315                 320 


Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala Thr Met Glu Asn 
                325                 330                 335     


Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln Met Ser Ala Phe 
            340                 345                 350         


Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala Ser Gly Arg Gln 
        355                 360                 365             


Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Ser Ser Gly Leu Val 
    370                 375                 380                 


Pro Arg Gly Ser His Met Arg Pro Met Thr Ala Lys Ile Phe Ala Val 
385                 390                 395                 400 


Asp Ser Val Arg Pro Ile Asp Glu Phe Glu Gln Asp Ala Leu Arg Val 
                405                 410                 415     


Ala Asp Val Ile Arg Glu Arg Gly Val Cys Leu Gly Asp Arg Val Met 
            420                 425                 430         


Leu Lys Ala Gly Asn Ser Ala Ser Tyr Val Cys Val Leu Tyr Ala Leu 
        435                 440                 445             


Met His Ile Gly Ala Ser Ile Val Leu Val Asp Gln Gln Glu His Lys 
    450                 455                 460                 


Glu Glu Thr Arg Arg Ile Ala Leu Arg Thr Gly Val Lys Val Thr Phe 
465                 470                 475                 480 


Val Asp Asp Glu Thr Pro Ile Asp Gln Asp Ala Asp Pro Ile His Leu 
                485                 490                 495     


Tyr Glu Leu Met Val Ala Thr Gln Asn Arg Pro Pro Met Asp Ser Ala 
            500                 505                 510         


Leu Ser Phe Asp Ala Trp Gly Glu Leu Ser Asp Gly Leu Ile Met Trp 
        515                 520                 525             


Thr Ser Gly Ser Thr Gly Ser Pro Lys Gly Val Val Lys Ser Gly Gly 
    530                 535                 540                 


Lys Phe Leu Ala Asn Leu Arg Arg Asn Ala His Gln Val Gly His Arg 
545                 550                 555                 560 


Pro Asp Asp Val Leu Met Pro Leu Leu Pro Phe Ala His Gln Tyr Gly 
                565                 570                 575     


Leu Ser Met Val Leu Ile Ala Trp Leu Thr Arg Cys Ser Leu Val Ile 
            580                 585                 590         


Ala Pro Tyr Arg Arg Leu Asp Arg Ala Leu Arg Met Ala Arg Asp Ser 
        595                 600                 605             


Gly Thr Thr Val Ile Asp Ala Thr Pro Ser Ser Tyr Arg Ser Ile Leu 
    610                 615                 620                 


Gly Leu Val Thr Arg Lys Pro Ala Leu Arg Ala His Leu Ala Gly Thr 
625                 630                 635                 640 


Arg Met Phe Cys Val Gly Ala Ala Pro Leu Asp Ala Pro Leu Val Glu 
                645                 650                 655     


Ser Tyr Val Gln Glu Phe Gly Leu Pro Leu Leu Asp Ser Tyr Gly Ser 
            660                 665                 670         


Thr Glu Leu Asn Asn Ile Ala Phe Ala Thr Leu Asp Asn Pro Val Ser 
        675                 680                 685             


Cys Gly Arg Ala Met Glu Gly Ile Gly Leu Arg Ile Val Asp Glu Asp 
    690                 695                 700                 


Gly Arg Glu Val Ala Ala Gly Gln Pro Gly Glu Ile Glu Val Asp Thr 
705                 710                 715                 720 


Pro Asp Ala Leu Glu Gly Gln Ile Ala Glu Asp Gly Ser Ile Ile Pro 
                725                 730                 735     


Ala Pro Thr Gly Trp Gln Arg Thr Gly Asp Leu Gly His Leu Asp Ala 
            740                 745                 750         


Asp Gly Asn Leu Tyr Val Leu Gly Arg Lys Phe Ala Val His Arg Met 
        755                 760                 765             


Gly Tyr Thr Leu Tyr Pro Glu Leu Ile Glu Arg Lys Val Ala Ala Glu 
    770                 775                 780                 


Gly Cys Pro Thr Arg Ile Val Pro Leu Pro Asp Glu Leu Arg Gly Ser 
785                 790                 795                 800 


Gln Leu Val Phe Phe Val Glu Asp Asp Glu Gln Arg Asp Ala Gly Tyr 
                805                 810                 815     


Trp Arg Glu Arg Leu Cys Gly Leu Leu Pro Ala Phe Glu Gln Pro Asn 
            820                 825                 830         


Lys Val Val Val Leu Glu Gln Phe Pro Leu Asn Arg Asn Gly Lys Pro 
        835                 840                 845             


Asp Lys Lys Glu Leu Thr Arg Met Ala Ala Glu 
    850                 855                 


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide designed to link MBP and ORF27

<400>  14

Ser Ser Gly Leu Val Pro Arg Gly Ser His 
1               5                   10  


<210>  15
<211>  447
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Asp Gln Thr Tyr Ser Leu Glu Ser Phe Leu Asn His Val Gln Lys 
1               5                   10                  15      


Arg Asp Pro Asn Gln Thr Glu Phe Ala Gln Ala Val Arg Glu Val Met 
            20                  25                  30          


Thr Thr Leu Trp Pro Phe Leu Glu Gln Asn Pro Lys Tyr Arg Gln Met 
        35                  40                  45              


Ser Leu Leu Glu Arg Leu Val Glu Pro Glu Arg Val Ile Gln Phe Arg 
    50                  55                  60                  


Val Val Trp Val Asp Asp Arg Asn Gln Ile Gln Val Asn Arg Ala Trp 
65                  70                  75                  80  


Arg Val Gln Phe Ser Ser Ala Ile Gly Pro Tyr Lys Gly Gly Met Arg 
                85                  90                  95      


Phe His Pro Ser Val Asn Leu Ser Ile Leu Lys Phe Leu Gly Phe Glu 
            100                 105                 110         


Gln Thr Phe Lys Asn Ala Leu Thr Thr Leu Pro Met Gly Gly Gly Lys 
        115                 120                 125             


Gly Gly Ser Asp Phe Asp Pro Lys Gly Lys Ser Glu Gly Glu Val Met 
    130                 135                 140                 


Arg Phe Cys Gln Ala Leu Met Thr Glu Leu Tyr Arg His Leu Gly Ala 
145                 150                 155                 160 


Asp Thr Asp Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu Val 
                165                 170                 175     


Gly Phe Met Ala Gly Met Met Lys Lys Leu Ser Asn Asn Thr Ala Cys 
            180                 185                 190         


Val Phe Thr Gly Lys Gly Leu Ser Phe Gly Gly Ser Leu Ile Arg Pro 
        195                 200                 205             


Glu Ala Thr Gly Tyr Gly Leu Val Tyr Phe Thr Glu Ala Met Leu Lys 
    210                 215                 220                 


Arg His Gly Met Gly Phe Glu Gly Met Arg Val Ser Val Ser Gly Ser 
225                 230                 235                 240 


Gly Asn Val Ala Gln Tyr Ala Ile Glu Lys Ala Met Glu Phe Gly Ala 
                245                 250                 255     


Arg Val Ile Thr Ala Ser Asp Ser Ser Gly Thr Val Val Asp Glu Ser 
            260                 265                 270         


Gly Phe Thr Lys Glu Lys Leu Ala Arg Leu Ile Glu Ile Lys Ala Ser 
        275                 280                 285             


Arg Asp Gly Arg Val Ala Asp Tyr Ala Lys Glu Phe Gly Leu Val Tyr 
    290                 295                 300                 


Leu Glu Gly Gln Gln Pro Trp Ser Leu Pro Val Asp Ile Ala Leu Pro 
305                 310                 315                 320 


Cys Ala Thr Gln Asn Glu Leu Asp Val Asp Ala Ser His Gln Leu Ile 
                325                 330                 335     


Ala Asn Gly Val Lys Ala Val Ala Glu Gly Ala Asn Met Pro Thr Thr 
            340                 345                 350         


Ile Glu Ala Thr Glu Leu Phe Gln Gln Ala Gly Val Leu Phe Ala Pro 
        355                 360                 365             


Gly Lys Ala Ala Asn Ala Gly Gly Val Ala Thr Ser Gly Leu Glu Met 
    370                 375                 380                 


Ala Gln Asn Ala Ala Arg Leu Gly Trp Lys Ala Glu Lys Val Asp Ala 
385                 390                 395                 400 


Arg Leu His His Ile Met Leu Asp Ile His His Ala Cys Val Glu His 
                405                 410                 415     


Gly Gly Glu Gly Glu Gln Thr Asn Tyr Val Gln Gly Ala Asn Ile Ala 
            420                 425                 430         


Gly Phe Val Lys Val Ala Asp Ala Met Leu Ala Gln Gly Val Ile 
        435                 440                 445         


<210>  16
<211>  390
<212>  PRT
<213>  Haloferax volcanii

<400>  16

Met Ser Pro Ala Pro Thr Asp Ile Val Glu Glu Phe Thr Arg Arg Asp 
1               5                   10                  15      


Trp Gln Gly Asp Asp Val Thr Gly Thr Val Arg Val Ala Met Ile Gly 
            20                  25                  30          


Leu Gly Trp Trp Thr Arg Asp Glu Ala Ile Pro Ala Val Glu Ala Ser 
        35                  40                  45              


Glu Phe Cys Glu Thr Thr Val Val Val Ser Ser Ser Lys Glu Lys Ala 
    50                  55                  60                  


Glu Gly Ala Thr Ala Leu Thr Glu Ser Ile Thr His Gly Leu Thr Tyr 
65                  70                  75                  80  


Asp Glu Phe His Glu Gly Val Ala Ala Asp Ala Tyr Asp Ala Val Tyr 
                85                  90                  95      


Val Val Thr Pro Asn Gly Leu His Leu Pro Tyr Val Glu Thr Ala Ala 
            100                 105                 110         


Glu Leu Gly Lys Ala Val Leu Cys Glu Lys Pro Leu Glu Ala Ser Val 
        115                 120                 125             


Glu Arg Ala Glu Lys Leu Val Ala Ala Cys Asp Arg Ala Asp Val Pro 
    130                 135                 140                 


Leu Met Val Ala Tyr Arg Met Gln Thr Glu Pro Ala Val Arg Arg Ala 
145                 150                 155                 160 


Arg Glu Leu Val Glu Ala Gly Val Ile Gly Glu Pro Val Phe Val His 
                165                 170                 175     


Gly His Met Ser Gln Arg Leu Leu Asp Glu Val Val Pro Asp Pro Asp 
            180                 185                 190         


Gln Trp Arg Leu Asp Pro Glu Leu Ser Gly Gly Ala Thr Val Met Asp 
        195                 200                 205             


Ile Gly Leu Tyr Pro Leu Asn Thr Ala Arg Phe Val Leu Asp Ala Asp 
    210                 215                 220                 


Pro Val Arg Val Arg Ala Thr Ala Arg Val Asp Asp Glu Ala Phe Glu 
225                 230                 235                 240 


Ala Val Gly Asp Glu His Val Ser Phe Gly Val Asp Phe Asp Asp Gly 
                245                 250                 255     


Thr Leu Ala Val Cys Thr Ala Ser Gln Ser Ala Tyr Gln Leu Ser His 
            260                 265                 270         


Leu Arg Val Thr Gly Thr Glu Gly Glu Leu Glu Ile Glu Pro Ala Phe 
        275                 280                 285             


Tyr Asn Arg Gln Lys Arg Gly Phe Arg Leu Ser Trp Gly Asp Gln Ser 
    290                 295                 300                 


Ala Asp Tyr Asp Phe Glu Gln Val Asn Gln Met Thr Glu Glu Phe Asp 
305                 310                 315                 320 


Tyr Phe Ala Ser Arg Leu Leu Ser Asp Ser Asp Pro Ala Pro Asp Gly 
                325                 330                 335     


Asp His Ala Leu Val Asp Met Arg Ala Met Asp Ala Ile Tyr Ala Ala 
            340                 345                 350         


Ala Glu Arg Gly Thr Asp Val Ala Val Asp Ala Ala Asp Ser Asp Ser 
        355                 360                 365             


Ala Asp Ser Asp Ser Ala Asp Ala Ala Ala Ala Asn His Asp Ala Asp 
    370                 375                 380                 


Pro Asp Ser Asp Gly Thr 
385                 390 


<210>  17
<211>  412
<212>  PRT
<213>  Haloferax volcanii

<400>  17

Met Val Glu Gln Ala Lys Leu Ser Asp Pro Asn Ala Glu Tyr Thr Met 
1               5                   10                  15      


Arg Asp Leu Ser Ala Glu Thr Ile Asp Ile Thr Asn Pro Arg Gly Gly 
            20                  25                  30          


Val Arg Asp Ala Glu Ile Thr Asp Val Gln Thr Thr Met Val Asp Gly 
        35                  40                  45              


Asn Tyr Pro Trp Ile Leu Val Arg Val Tyr Thr Asp Ala Gly Val Val 
    50                  55                  60                  


Gly Thr Gly Glu Ala Tyr Trp Gly Gly Gly Asp Thr Ala Ile Ile Glu 
65                  70                  75                  80  


Arg Met Lys Pro Phe Leu Val Gly Glu Asn Pro Leu Asp Ile Asp Arg 
                85                  90                  95      


Leu Tyr Glu His Leu Val Gln Lys Met Ser Gly Glu Gly Ser Val Ser 
            100                 105                 110         


Gly Lys Val Ile Ser Ala Ile Ser Gly Ile Glu Ile Ala Leu His Asp 
        115                 120                 125             


Val Ala Gly Lys Leu Leu Asp Val Pro Ala Tyr Gln Leu Val Gly Gly 
    130                 135                 140                 


Lys Tyr Arg Asp Glu Val Arg Val Tyr Cys Asp Leu His Thr Glu Asp 
145                 150                 155                 160 


Glu Ala Asn Pro Gln Ala Cys Ala Glu Glu Gly Val Arg Val Val Glu 
                165                 170                 175     


Glu Leu Gly Tyr Asp Ala Ile Lys Phe Asp Leu Asp Val Pro Ser Gly 
            180                 185                 190         


His Glu Lys Asp Arg Ala Asn Arg His Leu Arg Asn Pro Glu Ile Asp 
        195                 200                 205             


His Lys Val Glu Ile Val Glu Ala Val Thr Glu Ala Val Gly Asp Arg 
    210                 215                 220                 


Ala Asp Val Ala Phe Asp Cys His Trp Ser Phe Thr Gly Gly Ser Ala 
225                 230                 235                 240 


Lys Arg Leu Ala Ser Glu Leu Glu Asp Tyr Asp Val Trp Trp Leu Glu 
                245                 250                 255     


Asp Pro Val Pro Pro Glu Asn His Asp Val Gln Lys Leu Val Thr Gln 
            260                 265                 270         


Ser Thr Thr Thr Pro Ile Ala Val Gly Glu Asn Val Tyr Arg Lys Phe 
        275                 280                 285             


Gly Gln Arg Thr Leu Leu Glu Pro Gln Ala Val Asp Ile Ile Ala Pro 
    290                 295                 300                 


Asp Leu Pro Arg Val Gly Gly Met Arg Glu Thr Arg Lys Ile Ala Asp 
305                 310                 315                 320 


Leu Ala Asp Met Tyr Tyr Ile Pro Val Ala Met His Asn Val Ser Ser 
                325                 330                 335     


Pro Ile Gly Thr Met Ala Ser Ala Gln Val Ala Ala Ala Ile Pro Asn 
            340                 345                 350         


Ser Leu Ala Leu Glu Tyr His Ser Tyr Gln Leu Gly Trp Trp Glu Asp 
        355                 360                 365             


Leu Val Glu Glu Asp Asp Leu Ile Gln Asn Gly His Met Glu Ile Pro 
    370                 375                 380                 


Glu Lys Pro Gly Leu Gly Leu Thr Leu Asp Leu Asp Ala Val Glu Ala 
385                 390                 395                 400 


His Met Val Glu Gly Glu Thr Leu Phe Asp Glu Glu 
                405                 410         


<210>  18
<211>  289
<212>  PRT
<213>  Haloferax volcanii

<400>  18

Met His Tyr His Gln Leu Ala Val Ser Gly Glu Arg Arg Leu Thr Ala 
1               5                   10                  15      


Ser Arg Asp Ser Thr Thr Tyr Asp Leu Thr Ser Ala Asp Ala Asp Leu 
            20                  25                  30          


Arg Thr Phe Gly Asp Leu Ala Arg Val Ala Ser Ile Ala Arg Thr Ser 
        35                  40                  45              


Val Asp Arg Leu Ala Ala Glu Leu Thr Glu Asp Ala Asp Val Val Asp 
    50                  55                  60                  


Asp Ala Phe Val Asp Arg His Ala Thr Val Pro Val Asp Ala Glu Glu 
65                  70                  75                  80  


Ile Trp Ala Ala Gly Val Thr Tyr Gln Ile Ser Glu Gln Ala Arg Glu 
                85                  90                  95      


Glu Glu Ser Ser Met Pro Asp Met Tyr Phe Asp Val Tyr Asp Ala Asp 
            100                 105                 110         


Arg Pro Glu Val Phe Phe Lys Ala Thr Pro Ser Arg Thr Val Glu Pro 
        115                 120                 125             


Gly Asp Ala Ile Gly Val Arg Gly Asp Ser Glu Trp Asp Val Pro Glu 
    130                 135                 140                 


Pro Glu Leu Gly Ile Val Leu Arg Arg Gly Glu Ile Val Gly Tyr Thr 
145                 150                 155                 160 


Val Gly Asn Asp Val Ser Ser Arg Ser Ile Glu Gly Glu Asn Pro Leu 
                165                 170                 175     


Tyr Leu Pro Gln Ala Lys Val Tyr Asp Arg Cys Cys Ser Ile Gly Pro 
            180                 185                 190         


Cys Val Val Thr Pro Glu Asp Val Glu Asp Pro His Glu Leu Glu Met 
        195                 200                 205             


Ser Met Thr Ile Glu Arg Asp Gly Glu Val Ile Tyr Asp Asp Ala Thr 
    210                 215                 220                 


Asn Thr Ser Glu Met Val Arg Ser Cys Asp Glu Leu Val Ser Tyr Phe 
225                 230                 235                 240 


Thr Arg His Asn Thr Val Pro Glu Leu Ala Val Ile Leu Thr Gly Thr 
                245                 250                 255     


Ser Leu Val Pro Glu Gln Pro Phe Asp Leu Gln Glu Gly Asp His Val 
            260                 265                 270         


Asp Ile Thr Ile Glu Gly Ile Gly Thr Leu Ser Asn Ser Val Thr Thr 
        275                 280                 285             


Val 
    


<210>  19
<211>  482
<212>  PRT
<213>  Haloferax volcanii

<400>  19

Met Thr Asp Pro Ser Lys Asn Tyr Val Asn Gly Glu Trp Val Thr Ser 
1               5                   10                  15      


Glu Thr Gly Glu Thr Thr Glu Val Thr Asn Pro Ala Asn Pro Ser Glu 
            20                  25                  30          


Val Val Ala Ala Tyr Gln His Ser Asn Glu Asn Asp Ala Ala Ala Ala 
        35                  40                  45              


Val Asp Ala Ala Val Ala Ala Glu Asp Glu Trp Arg Asn Thr Pro Gly 
    50                  55                  60                  


Pro Glu Arg Gly Arg Ile Leu Arg Glu Ala Gly Thr Leu Leu Ala Gln 
65                  70                  75                  80  


Arg Lys Asp Glu Leu Thr Glu Ile Leu Thr Ala Glu Glu Gly Lys Ala 
                85                  90                  95      


Arg Pro Glu Ala Ala Gly Glu Val Gln Arg Ala Ile Asp Ile Phe His 
            100                 105                 110         


Tyr Phe Ser Ser Lys Ala Ala Asp Leu Gly Gly Thr Lys Lys Gly Ala 
        115                 120                 125             


Ser Gly Pro Asn Thr Asn Leu Tyr Thr Arg Gln Glu Pro Val Gly Val 
    130                 135                 140                 


Ala Ala Leu Ile Thr Pro Trp Asn Tyr Pro Ile Ala Ile Pro Ala Trp 
145                 150                 155                 160 


Lys Leu Ala Pro Ala Leu Ala Ala Gly Asn Thr Val Val Leu Lys Pro 
                165                 170                 175     


Ala Ser Ile Ala Pro Gly Val Val Ile Glu Ile Ala Arg Ala Leu Asp 
            180                 185                 190         


Glu Ala Gly Leu Pro Asp Gly Val Leu Asn Val Val Thr Gly Pro Gly 
        195                 200                 205             


Ser Ser Val Gly Ser Glu Phe Ile Gly Asn Glu Gly Thr Asp Leu Val 
    210                 215                 220                 


Ser Phe Thr Gly Ser Ser Gln Val Gly Glu Met Val Tyr Glu Gln Ala 
225                 230                 235                 240 


Thr Asp Ala Gly Lys Arg Val Gln Thr Glu Leu Gly Gly Lys Asn Pro 
                245                 250                 255     


Thr Leu Val Ala Asp Ser Ala Asn Pro Ala Glu Ala Ala Asp Ile Val 
            260                 265                 270         


Ala Asn Gly Gly Phe Gly Thr Thr Gly Gln Ser Cys Thr Ala Cys Ser 
        275                 280                 285             


Arg Ala Ile Val His Glu Asp Val Tyr Asp Asp Phe Val Ala Glu Leu 
    290                 295                 300                 


Val Asp Arg Ala Glu Ser Leu Asp Val Gly Pro Gly Thr Asp His Glu 
305                 310                 315                 320 


Met Gly Pro Gln Val Ser Glu Ser Glu Leu Ser Ser Thr Leu Glu Tyr 
                325                 330                 335     


Ile Asp Ile Ala Glu Ala Glu Gly Ala Thr Leu Val Ala Gly Gly Gly 
            340                 345                 350         


Val Pro Glu Gly Glu Ala Val Glu Thr Gly His Phe Val Glu Pro Thr 
        355                 360                 365             


Val Phe Thr Asp Val Asp Pro Asp Met Arg Ile Ala Gln Glu Glu Val 
    370                 375                 380                 


Phe Gly Pro Val Val Ala Val Ile Glu Val Ser Asp Phe Asp Glu Gly 
385                 390                 395                 400 


Leu Ala Val Ala Asn Asp Val Asp Tyr Gly Leu Ser Ala Ser Ile Val 
                405                 410                 415     


Thr Asp Asp His Thr Glu Ala Asn Arg Phe Val Asp Glu Val Glu Ala 
            420                 425                 430         


Gly Val Val Lys Val Asn Asp Lys Thr Thr Gly Leu Glu Leu His Val 
        435                 440                 445             


Pro Phe Gly Gly Phe Lys Arg Ser Ser Ser Glu Thr Trp Arg Glu Gln 
    450                 455                 460                 


Gly Asp Ala Gly Leu Asp Phe Tyr Thr Ile Glu Lys Thr Val Tyr Asp 
465                 470                 475                 480 


Ser Tyr 
        


<210>  20
<211>  547
<212>  PRT
<213>  Lactococcus lactis

<400>  20

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Glu Asp Met Lys Trp Ile Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ile 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Asp Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Tyr 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Gln Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ala Leu Ser Leu Glu Lys Glu Ser Ser Thr Thr Asn Thr Thr Glu Gln 
            180                 185                 190         


Val Ile Leu Ser Lys Ile Glu Glu Ser Leu Lys Asn Ala Gln Lys Pro 
        195                 200                 205             


Val Val Ile Ala Gly His Glu Val Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Val Ser Glu Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ala Val Asp Glu Ser Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Ile Ser Leu Lys Asn Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asp Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Ile Ile Phe Asn Lys Val Val Glu Asp Phe Asp Phe 
305                 310                 315                 320 


Arg Ala Val Val Ser Ser Leu Ser Glu Leu Lys Gly Ile Glu Tyr Glu 
                325                 330                 335     


Gly Gln Tyr Ile Asp Lys Gln Tyr Glu Glu Phe Ile Pro Ser Ser Ala 
            340                 345                 350         


Pro Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Ser Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Thr Ile Phe Leu Lys Ser Asn Ser Arg Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ser Ile Arg Glu Lys Leu Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Thr Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Thr Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Val Asn Arg Met Tyr Trp Ile Glu Leu Val Leu Glu Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Leu Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys 
545         


<210>  21
<211>  453
<212>  PRT
<213>  Vibrio fluvialis

<400>  21

Met Asn Lys Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Phe Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  22
<211>  384
<212>  PRT
<213>  Azotobacter vinelandii

<400>  22

Met Ala Ser Val Ile Ile Asp Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Ser Ala Gly Val Ala Phe Asn Ala Asp Glu Lys Ile Ala Ile Ala Arg 
            20                  25                  30          


Ala Leu Ala Glu Leu Gly Val Pro Glu Leu Glu Ile Gly Ile Pro Ser 
        35                  40                  45              


Met Gly Glu Glu Glu Arg Glu Val Met His Ala Ile Ala Gly Leu Gly 
    50                  55                  60                  


Leu Ser Ser Arg Leu Leu Ala Trp Cys Arg Leu Cys Asp Val Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Thr Gly Val Thr Met Val Asp Leu Ser Leu Pro 
                85                  90                  95      


Val Ser Asp Leu Met Leu His His Lys Leu Asn Arg Asp Arg Asp Trp 
            100                 105                 110         


Ala Leu Arg Glu Val Ala Arg Leu Val Gly Glu Ala Arg Met Ala Gly 
        115                 120                 125             


Leu Glu Val Cys Leu Gly Cys Glu Asp Ala Ser Arg Ala Asp Leu Glu 
    130                 135                 140                 


Phe Val Val Gln Val Gly Glu Val Ala Gln Ala Ala Gly Ala Arg Arg 
145                 150                 155                 160 


Leu Arg Phe Ala Asp Thr Val Gly Val Met Glu Pro Phe Gly Met Leu 
                165                 170                 175     


Asp Arg Phe Arg Phe Leu Ser Arg Arg Leu Asp Met Glu Leu Glu Val 
            180                 185                 190         


His Ala His Asp Asp Phe Gly Leu Ala Thr Ala Asn Thr Leu Ala Ala 
        195                 200                 205             


Val Met Gly Gly Ala Thr His Ile Asn Thr Thr Val Asn Gly Leu Gly 
    210                 215                 220                 


Glu Arg Ala Gly Asn Ala Ala Leu Glu Glu Cys Val Leu Ala Leu Lys 
225                 230                 235                 240 


Asn Leu His Gly Ile Asp Thr Gly Ile Asp Thr Arg Gly Ile Pro Ala 
                245                 250                 255     


Ile Ser Ala Leu Val Glu Arg Ala Ser Gly Arg Gln Val Ala Trp Gln 
            260                 265                 270         


Lys Ser Val Val Gly Ala Gly Val Phe Thr His Glu Ala Gly Ile His 
        275                 280                 285             


Val Asp Gly Leu Leu Lys His Arg Arg Asn Tyr Glu Gly Leu Asn Pro 
    290                 295                 300                 


Asp Glu Leu Gly Arg Ser His Ser Leu Val Leu Gly Lys His Ser Gly 
305                 310                 315                 320 


Ala His Met Val Arg Asn Thr Tyr Arg Asp Leu Gly Ile Glu Leu Ala 
                325                 330                 335     


Asp Trp Gln Ser Gln Ala Leu Leu Gly Arg Ile Arg Ala Phe Ser Thr 
            340                 345                 350         


Arg Thr Lys Arg Ser Pro Gln Pro Ala Glu Leu Gln Asp Phe Tyr Arg 
        355                 360                 365             


Gln Leu Cys Glu Gln Gly Asn Pro Glu Leu Ala Ala Gly Gly Met Ala 
    370                 375                 380                 


<210>  23
<211>  421
<212>  PRT
<213>  Methanococcus aeolicus

<400>  23

Met Thr Leu Ala Glu Glu Ile Leu Ser Lys Lys Val Gly Lys Lys Val 
1               5                   10                  15      


Lys Ala Gly Asp Val Val Glu Ile Asp Ile Asp Leu Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Ser Ala Lys Ala Phe Lys Gln Ile Thr Asp 
        35                  40                  45              


Lys Val Trp Asp Asn Lys Lys Ile Val Ile Val Phe Asp His Asn Val 
    50                  55                  60                  


Pro Ala Asn Thr Leu Lys Ala Ala Asn Met Gln Lys Ile Thr Arg Glu 
65                  70                  75                  80  


Phe Ile Lys Glu Gln Asn Ile Ile Asn His Tyr Leu Asp Gly Glu Gly 
                85                  90                  95      


Val Cys His Gln Val Leu Pro Glu Asn Gly His Ile Gln Pro Asn Met 
            100                 105                 110         


Val Ile Ala Gly Gly Asp Ser His Thr Cys Thr Tyr Gly Ala Phe Gly 
        115                 120                 125             


Ala Phe Ala Thr Gly Phe Gly Ala Thr Asp Met Gly Asn Ile Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Leu Lys Val Pro Lys Thr Ile Arg Ile Asn Val 
145                 150                 155                 160 


Asn Gly Glu Asn Asp Lys Ile Thr Gly Lys Asp Ile Ile Leu Lys Ile 
                165                 170                 175     


Cys Lys Glu Val Gly Arg Ser Gly Ala Thr Tyr Met Ala Leu Glu Tyr 
            180                 185                 190         


Gly Gly Glu Ala Ile Lys Lys Leu Ser Met Asp Glu Arg Met Val Leu 
        195                 200                 205             


Ser Asn Met Ala Ile Glu Met Gly Gly Lys Val Gly Leu Ile Glu Ala 
    210                 215                 220                 


Asp Glu Thr Thr Tyr Asn Tyr Leu Arg Asn Val Gly Ile Ser Glu Glu 
225                 230                 235                 240 


Lys Ile Leu Glu Leu Lys Lys Asn Gln Ile Thr Ile Asp Glu Asn Asn 
                245                 250                 255     


Ile Asp Asn Asp Asn Tyr Tyr Lys Ile Ile Asn Ile Asp Ile Thr Asp 
            260                 265                 270         


Met Glu Glu Gln Val Ala Cys Pro His His Pro Asp Asn Val Lys Asn 
        275                 280                 285             


Ile Ser Glu Val Lys Gly Ala Pro Ile Asn Gln Val Phe Ile Gly Ser 
    290                 295                 300                 


Cys Thr Asn Gly Arg Leu Asn Asp Leu Arg Ile Ala Ser Lys Tyr Leu 
305                 310                 315                 320 


Lys Gly Lys Lys Val His Asn Asp Val Arg Leu Ile Val Ile Pro Ala 
                325                 330                 335     


Ser Lys Ser Ile Phe Lys Gln Ala Leu Lys Glu Gly Leu Ile Asp Ile 
            340                 345                 350         


Phe Val Asp Ala Gly Ala Leu Ile Cys Thr Pro Gly Cys Gly Pro Cys 
        355                 360                 365             


Leu Gly Ala His Gln Gly Val Leu Gly Asp Gly Glu Val Cys Leu Ala 
    370                 375                 380                 


Thr Thr Asn Arg Asn Phe Lys Gly Arg Met Gly Asn Thr Thr Ala Glu 
385                 390                 395                 400 


Ile Tyr Leu Ser Ser Pro Ala Ile Ala Ala Lys Ser Ala Ile Lys Gly 
                405                 410                 415     


Tyr Ile Thr Asn Glu 
            420     


<210>  24
<211>  165
<212>  PRT
<213>  Methanococcus aeolicus

<400>  24

Met Ile Ile Lys Gly Asn Ile His Leu Phe Gly Asp Asp Ile Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Ala Tyr Leu Lys Thr Thr Asp Pro Lys Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Lys Phe Ser Thr Lys 
        35                  40                  45              


Val Lys Asp Gly Asp Ile Ile Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Pro Ile Ser Ile Lys His Thr Gly Ile Lys 
65                  70                  75                  80  


Ala Val Val Ala Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn Cys Ile 
                85                  90                  95      


Asn Ile Gly Leu Ile Pro Ile Thr Cys Glu Gly Ile Asn Glu Gln Ile 
            100                 105                 110         


Gln Asn Leu Lys Asp Gly Asp Thr Ile Glu Ile Asp Leu Gln Asn Glu 
        115                 120                 125             


Thr Ile Lys Ile Asn Ser Met Met Leu Asn Cys Gly Ala Pro Lys Gly 
    130                 135                 140                 


Ile Glu Lys Glu Ile Leu Asp Ala Gly Gly Leu Val Gln Tyr Thr Lys 
145                 150                 155                 160 


Asn Lys Leu Lys Lys 
                165 


