                         SEQUENCE LISTING

<110>  Eli Lilly and Company
       Ambrx Inc.
 
<120>  Pegylated Porcine Interferon and Methods of Use Thereof

<130>  204257-0028-00-WO-561478

<150>  62/352,163
<151>  2016-06-20

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xa is Pro or absent

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xb is Pro, Ser or absent, wherein when Xb is absent, Xa is 
       absent, when Xb is Pro, Xa is absent, and when Xb is Ser, Xa is 
       Pro

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  may be substituted with a synthetic amino acid

<400>  1

Xaa Xaa Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro 
            100                 105                 110         


Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  2
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  may be removed in mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xa is Pro or absent

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xb is Pro, Ser or absent, wherein when Xb is absent, Xa is 
       absent, when Xb is Pro, Xa is absent, and when Xb is Ser, Xa is 
       Pro

<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  may be substituted with a synthetic amino acid

<400>  2

Met Xaa Xaa Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg 
1               5                   10                  15      


Ala Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys 
            20                  25                  30          


Leu Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly 
        35                  40                  45              


Asn Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu 
    50                  55                  60                  


Gln Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp 
65                  70                  75                  80  


Asn Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu 
                85                  90                  95      


Arg Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr 
            100                 105                 110         


Pro Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His 
        115                 120                 125             


Arg Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp 
    130                 135                 140                 


Glu Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn 
145                 150                 155                 160 


Leu Gln Asp Arg Leu Arg Lys Lys Glu 
                165                 


<210>  3
<211>  189
<212>  PRT
<213>  Sus scrofa


<220>
<221>  mat_peptide
<222>  (24)..(189)

<400>  3

Met Ala Pro Thr Ser Ala Phe Leu Thr Ala Leu Val Leu Leu Ser Cys 
            -20                 -15                 -10         


Asn Ala Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
        -5              -1  1               5                   


Ala His Thr Arg Ala Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser 
10                  15                  20                  25  


Pro Phe Ser Cys Leu Asp His Arg Arg Asp Phe Gly Ser Pro His Glu 
                30                  35                  40      


Ala Phe Gly Gly Asn Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val 
            45                  50                  55          


His Glu Met Leu Gln Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser 
        60                  65                  70              


Ala Ala Ala Trp Asn Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu 
    75                  80                  85                  


Asp Gln Gln Leu Arg Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly 
90                  95                  100                 105 


Leu Glu Gly Thr Pro Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg 
                110                 115                 120     


Lys Tyr Phe His Arg Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser 
            125                 130                 135         


Pro Cys Ala Trp Glu Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser 
        140                 145                 150             


Ser Ser Arg Asn Leu Gln Asp Arg Leu Arg Lys Lys Glu 
    155                 160                 165     


<210>  4
<211>  166
<212>  PRT
<213>  Sus scrofa


<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  may be substituted with a synthetic amino acid

<400>  4

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  5
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  may be removed in mature polypeptide

<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  may be substituted with a synthetic amino acid

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  may be substituted with a synthetic amino acid

<400>  5

Met Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  6
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  para-acetyl-phenylalanine (pAF)

<400>  6

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Xaa Glu Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  7
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  para-acetyl-phenylalanine (pAF)

<400>  7

Pro Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Xaa Glu Ala Gly Leu Glu Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  8
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  para-acetyl-phenylalanine (pAF)

<400>  8

Pro Ser Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Xaa Glu Ala Gly Leu Glu Gly Thr Pro 
            100                 105                 110         


Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  9
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (103)..(103)
<223>  para-acetyl-phenylalanine (pAF)

<400>  9

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Xaa Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  10
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  para-acetyl-phenylalanine (pAF)

<400>  10

Pro Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Xaa Ala Gly Leu Glu Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  11
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (105)..(105)
<223>  para-acetyl-phenylalanine (pAF)

<400>  11

Pro Ser Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Gln Xaa Ala Gly Leu Glu Gly Thr Pro 
            100                 105                 110         


Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  12
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  para-acetyl-phenylalanine (pAF)

<400>  12

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Xaa Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  13
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  para-acetyl-phenylalanine (pAF)

<400>  13

Pro Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Xaa Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  14
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  para-acetyl-phenylalanine (pAF)

<400>  14

Pro Ser Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Xaa Gly Thr Pro 
            100                 105                 110         


Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  15
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  para-acetyl-phenylalanine (pAF)

<400>  15

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu Xaa 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  16
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  para-acetyl-phenylalanine (pAF)

<400>  16

Pro Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu 
            100                 105                 110         


Xaa Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  17
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (114)..(114)
<223>  para-acetyl-phenylalanine (pAF)

<400>  17

Pro Ser Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro 
            100                 105                 110         


Leu Xaa Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  18
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (136)..(136)
<223>  para-acetyl-phenylalanine (pAF)

<400>  18

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Xaa Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  19
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  para-acetyl-phenylalanine (pAF)

<400>  19

Pro Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Xaa Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  20
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (138)..(138)
<223>  para-acetyl-phenylalanine (pAF)

<400>  20

Pro Ser Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro 
            100                 105                 110         


Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Xaa Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  21
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  para-acetyl-phenylalanine (pAF)

<400>  21

Cys Asp Leu Pro Gln Thr Xaa Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  22
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  para-acetyl-phenylalanine (pAF)

<400>  22

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Xaa Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  23
<211>  166
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  para-acetyl-phenylalanine (pAF)

<400>  23

Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu Arg 
1               5                   10                  15      


Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp His 
            20                  25                  30          


Arg Arg Asp Phe Gly Ser Pro Xaa Glu Ala Phe Gly Gly Asn Gln Val 
        35                  40                  45              


Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln Thr 
    50                  55                  60                  


Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Met Gln Glu Ala Gly Leu Glu Gly Thr Pro Leu Leu 
            100                 105                 110         


Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu Thr 
        115                 120                 125             


Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile Val 
    130                 135                 140                 


Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln Asp 
145                 150                 155                 160 


Arg Leu Arg Lys Lys Glu 
                165     


<210>  24
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  para-acetyl-phenylalanine (pAF)

<400>  24

Ser Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Xaa Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


<210>  25
<211>  168
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  para-acetyl-phenylalanine (pAF)

<400>  25

Ser Gly Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala 
1               5                   10                  15      


Leu Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu 
            20                  25                  30          


Asp His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn 
        35                  40                  45              


Gln Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln 
    50                  55                  60                  


Gln Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn 
65                  70                  75                  80  


Glu Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg 
                85                  90                  95      


Asp Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Xaa Gly Thr Pro 
            100                 105                 110         


Leu Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg 
        115                 120                 125             


Leu Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu 
    130                 135                 140                 


Ile Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu 
145                 150                 155                 160 


Gln Asp Arg Leu Arg Lys Lys Glu 
                165             


<210>  26
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (108)..(108)
<223>  para-acetyl-phenylalanine (pAF)

<400>  26

His Cys Asp Leu Pro Gln Thr His Ser Leu Ala His Thr Arg Ala Leu 
1               5                   10                  15      


Arg Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Asp 
            20                  25                  30          


His Arg Arg Asp Phe Gly Ser Pro His Glu Ala Phe Gly Gly Asn Gln 
        35                  40                  45              


Val Gln Lys Ala Gln Ala Met Ala Leu Val His Glu Met Leu Gln Gln 
    50                  55                  60                  


Thr Phe Gln Leu Phe Ser Thr Glu Gly Ser Ala Ala Ala Trp Asn Glu 
65                  70                  75                  80  


Ser Leu Leu His Gln Phe Tyr Thr Gly Leu Asp Gln Gln Leu Arg Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Ala Gly Leu Xaa Gly Thr Pro Leu 
            100                 105                 110         


Leu Glu Glu Asp Ser Ile Arg Ala Val Arg Lys Tyr Phe His Arg Leu 
        115                 120                 125             


Thr Leu Tyr Leu Gln Glu Lys Ser Tyr Ser Pro Cys Ala Trp Glu Ile 
    130                 135                 140                 


Val Arg Ala Glu Val Met Arg Ser Phe Ser Ser Ser Arg Asn Leu Gln 
145                 150                 155                 160 


Asp Arg Leu Arg Lys Lys Glu 
                165         


